This page contains the final submissions from 2020 for the convenience of those entering the same or similar information for 2021.
NOTE: This page can only be reached by direct link. It cannot be reached through the menu of summerresearch.med.wisc.edu.
The Project Information column below contains the Project Title and Project Description before the dividing line. After the dividing line are the Role, IRB Status, and Skills entries.
| Timestamp | Department | Opportunities | Project Info | Open Slots | Email Address | Mentor First Name | Mentor Last Name | Degree | Mentor Information | Title | Phone Number | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Please list all relevant manuscripts (published or in preparation) in the last 5 years that are directly relevant to the project you proposed. | Have you completed any mentoring training? | Please include names and contact information of key staff in your department or lab who will need to be informed of your incoming Shapiro students | Response URL |
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| 21/11/2019 | Pediatrics | Shorter term projects | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning: The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - N/A; Skills - Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | 0 | epetty@wisc.edu | Elizabeth | Petty | MD | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: Sherryl Pertzborn, MBA; Kendra Hogan, MS, MPH, JD | Professor, Senior Associate Dean | 608 | Pediatrics - Genetics and Metabolism | Other | Academic Affairs - Dean's Office Administration | Sherryl Pertzborn, MBA; Kendra Hogan, MS, MPH, JD | Other | Academic Affairs - Dean's Office Administration | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning | The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. | Depends on student’s interests | Students will meet with mentors formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily avaiable. | Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | N/A | Yes | Yes | Yes | Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | N/A | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuehiOW9caGSV6b8O97Sph0Z4VNJVCtn7sBgOM0HzdIddzg3RIp1elELKhzESSc-TxY | |
| 21/11/2019 | Pediatrics | Shorter term projects | Applications and Implications of Genetics and Genomics - An Understanding of Professional and Public Perspectives: Medical and/or Genetic Counselor students will have an opportunity to work with existing data sets or create new ones that explore the clinical, economic, ethical, legal, and/or sociopolictical impacts of advances of applications in genetic/genomic knowledge on individuals and populations depending on which project in this area they chose. The student(s) have an opportunity to chose from different projects and develop their focus of interest. Students will be also encouraged to attend genetics clinic conferences and shadow in genetics clinics. This research will be geared toward students who have interests in a career that includes serving individuals, families, or populations with, or at risk for, genetic conditions. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - Depends on specific project, for projects where IRB is needed, IRB already exisits or will be in place.; Skills - Outstanding computer, communication, and collaboration skills are essential. Past expereince with hypothesis driven research, surveys, and data analysis a plus. | 0 | epetty@wisc.edu | Elizabeth | Petty | MD | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: Casey Reiser, MS | Professor, Pediatrics | 608 | Genetics and Metabolism | Other | Academic Affairs - Deans Office Administration | Casey Reiser, MS | Pediatrics | Genetics and Metabolism | Applications and Implications of Genetics and Genomics - An Understanding of Professional and Public Perspectives | Medical and/or Genetic Counselor students will have an opportunity to work with existing data sets or create new ones that explore the clinical, economic, ethical, legal, and/or sociopolictical impacts of advances of applications in genetic/genomic knowledge on individuals and populations depending on which project in this area they chose. The student(s) have an opportunity to chose from different projects and develop their focus of interest. Students will be also encouraged to attend genetics clinic conferences and shadow in genetics clinics. This research will be geared toward students who have interests in a career that includes serving individuals, families, or populations with, or at risk for, genetic conditions. | Depends on student’s interests | Students will meet formally with mentors once each week and have informal interactions as needed to ensure sucess of the project. The student will be expected to follow a timeline and make progress on all agreed upon goals in an independent manner. | Outstanding computer, communication, and collaboration skills are essential. Past expereince with hypothesis driven research, surveys, and data analysis a plus. | Depends on specific project, for projects where IRB is needed, IRB already exisits or will be in place. | No | Yes | Yes | Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | N/A | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudhFrIrxHX5knB13yVLoAEAQcg1KYnmyZbYzBNemuEUfsCFe0PZoBlCndQb-vu_vg0 | |
| 21/11/2019 | Surgery | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Use of human skin to model burn injury and complex wound healing: There are various projects in different stages of maturity in the Gibson lab that would be suitable for a medical student to contribute to over the summer, depending on their interests, including the following two projects with direct clinical applicability. One project involves a feasibility study of ICG fluorescence as a biomarker for necrosis in human burn wounds - this is a translational project on burn patients as well as developing assays in the lab to evaluate the mechanism. Another project involves the evaluation of the cytotoxicity and efficacy of antiseptics in infected human skin wounds. For more information on the Gibson lab please visit: https://www.surgery.wisc.edu/research/researchers-labs/dr-gibsons-lab/ ____________________________________________________________________________ Role - Taking the lead on a part of the project with direct oversight from scientist in lab; IRB Status - approved; Skills - prior research experience with tissue culture and molecular biology preferred but not necessary | 0 | gibson@surgery.wisc.edu | Angela | Gibson | MD, PhD | Angela Gibson, gibson@surgery.wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.659.574 | Acute Care and Regional General Surgery | Use of human skin to model burn injury and complex wound healing | There are various projects in different stages of maturity in the Gibson lab that would be suitable for a medical student to contribute to over the summer, depending on their interests, including the following two projects with direct clinical applicability. One project involves a feasibility study of ICG fluorescence as a biomarker for necrosis in human burn wounds - this is a translational project on burn patients as well as developing assays in the lab to evaluate the mechanism. Another project involves the evaluation of the cytotoxicity and efficacy of antiseptics in infected human skin wounds. For more information on the Gibson lab please visit: https://www.surgery.wisc.edu/research/researchers-labs/dr-gibsons-lab/ | Taking the lead on a part of the project with direct oversight from scientist in lab | independent after training on techniques | prior research experience with tissue culture and molecular biology preferred but not necessary | approved | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students | Karim, A., Shaum, K., Gibson, A. “Indeterminate depth burn injury - Exploring the uncertainty.” Journal of Surgical Research. 2020 Jan;245:183-917. Published online August 14 2019. Karim, A., Yan, A., Ocotl, E., Bennett, D., Wang, Z., Kendiorski, C., Gibson, A. “Discordance between histologic and visual assessment of tissue viability in excised burn wound tissue”. Wound Repair and Regeneration. 2019 Mar;27(2):150-161. Epub 2018 Dec 26. Gibson, A., Bennett, D., Taylor, L. “Improving the histologic characterization of burn depth.” Journal of Cutaneous Pathology. 2017 Dec;44(12):998-1004. Gibson, A., Shatadal, S. “A simplified and improved method to determine cell viability in burn-injured tissue.” Journal of Surgical Research.2017 Jul;215:83-87. Israel, J., Greenhalgh, D., Gibson, A. “Variations in burn excision and grafting: A survey of the American Burn Association.” Journal of Burn Care and Research. 2017 Jan/Feb;38(1):e125-e132. Schroeder, A.; Karim, A., Ocotl, E., Dones, J., Chacko, J., Liu, A., Raines, R., Gibson, A., Eliceiri, K., Optical imaging of collagen fiber damage to assess thermally injured human skin. In preparation with revisions to Wound Repair and Regeneration. | No | Dr. Aiping Liu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucoe5Qj0mNjBhhfXnvDRfPQd1e3H6k_mkesFgJhgCWphi7ze2-H00Zqye43oIB3SYA | ||||||
| 03/01/2020 | Urology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Urology Health Services Research: I have been working with medical students through the Shapiro program for the past 5 years and have thoroughly enjoyed these experiences. I try to tailor the experience to the goals of the student. For example, if the student is interesting in writing a manuscript, I have large prostate cancer and bladder cancer datasets available for additional exploration that could lead to streamlined analysis and manuscript writing. If the student is interested in learning about clinical trials, I currently have two trials that I am principal investigator for. The student could take a lead role as a research assistant for these trials. The first is a prospective study looking at opioid use following urologic surgeries. The second study is a randomized prospective clinical trial that examines the utility of urine testing immediately preceding urologic office procedures. I look forward to discussing these opportunities with students that are interested in "doing" research or writing papers as opposed to mining the electronic health record collecting data. ____________________________________________________________________________ Role - Writer, interact with potential patients, consent patients, collect data, analyze data, perform follow-up interviews with subjects; IRB Status - Approved; Skills - Able to be part of a team | 0 | richardsk@urology.wisc.edu | Kyle | Richards | MD FACS | Kyle Richards, richardsk@urology.wisc.edu -- Co-Mentor: | Assistant Professor | 6.089.603.337 | Urology Health Services Research | I have been working with medical students through the Shapiro program for the past 5 years and have thoroughly enjoyed these experiences. I try to tailor the experience to the goals of the student. For example, if the student is interesting in writing a manuscript, I have large prostate cancer and bladder cancer datasets available for additional exploration that could lead to streamlined analysis and manuscript writing. If the student is interested in learning about clinical trials, I currently have two trials that I am principal investigator for. The student could take a lead role as a research assistant for these trials. The first is a prospective study looking at opioid use following urologic surgeries. The second study is a randomized prospective clinical trial that examines the utility of urine testing immediately preceding urologic office procedures. I look forward to discussing these opportunities with students that are interested in "doing" research or writing papers as opposed to mining the electronic health record collecting data. | Writer, interact with potential patients, consent patients, collect data, analyze data, perform follow-up interviews with subjects | Moderate | Able to be part of a team | Approved | No | Yes | Yes | Not currently available to mentor other students | [1] Anderson-Carter I, Posielski N, Liou J, Khemees TA, Downs TM, Abel EJ, Jarrard DF, and Richards KA. The impact of statins in combination with androgen deprivation therapy in patients with advanced prostate cancer: A large observational study. Urologic Oncology: Seminars and Original Investigations 2019; 37(2): 130-7. [2] Etheridge T, Liou J, Downs TM, Abel EJ, Jarrard DJ, and Richards KA. The impact of Agent Orange on prostate cancer outcomes. Journal of Urology 2019; 201(4): 742-50. [3] Richards KA, Cesario S, Best SL, Deeren S, Bushman W, and Safdar N. Reflex urine culture testing in an ambulatory urology clinic: Implications for antibiotic stewardship in urology. International Journal of Urology 2019; 26(1): 69-74. [4] Richards KA, Liou J, Cryns VL, Downs TM, Abel EJ, and Jarrard DF. Metformin use is associated with improved survival in patients with advanced prostate cancer on androgen deprivation therapy. Journal of Urology 2018; 200(6): 1256-1263. [5] Maciolek KA, Best SL, Lopez V, Posielski N, Knoedler M, Bushman WA, Jarrard DF, Downs TM, Abel EJ, and Richards KA. Effectiveness of a transresctal prostate needle biopsy protocol with risk-tailored antimicrobials in a Veterans cohort. Urologic Oncology: Seminars and Original Investigations 2018; 36(8): 363.e13-363.e20. | No | Denise Mussehl (mussehl@urology.wisc.edu) and Steve Hall (hall@urology.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudl-3gxTINtSSFmOp7MTfcZf0FvW04avIfY79Q-VAAUcWb9PpEaYQRyxzyQnrcNsZ8 | |||||||
| 25/11/2019 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU: This project will be analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. There will likely also be a component of participating in enrolling patients in a clinical research study - consent, enrollment, placement of monitors, etc. https://www.pediatrics.wisc.edu/research/research-groups/harer/ ____________________________________________________________________________ Role - The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad. This project will be flexible with time requirements. Students will work closely with a Neonatal Fellow and Assistant Professor Attending, meeting multiple times per week. The student will also have the opportunity to shadow in the NICU. ; IRB Status - Approved; Skills - CITI training preferred but not required, can be completed at the beginning of the summer. Previous clinical research and consent experience ideal. | 0 | mwharer@wisc.edu | Matthew | Harer | MD | Matthew Harer, mwharer@wisc.edu -- Co-Mentor: | Assistant Professor | Neonatology | Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU | This project will be analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. There will likely also be a component of participating in enrolling patients in a clinical research study - consent, enrollment, placement of monitors, etc. https://www.pediatrics.wisc.edu/research/research-groups/harer/ | The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad. This project will be flexible with time requirements. Students will work closely with a Neonatal Fellow and Assistant Professor Attending, meeting multiple times per week. The student will also have the opportunity to shadow in the NICU. | Moderate, mentor always available for questions. | CITI training preferred but not required, can be completed at the beginning of the summer. Previous clinical research and consent experience ideal. | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | 1. Starr MC, Hingorani SR. Prematurity and future kidney health: the growing risk of chronic kidney disease. Curr Opin Pediatr 2018, 30(2): 228-235. 2. Jetton JG, Boohaker LJ, Sethi SK, Wazir S, Rohatgi S, Soranno DE, et al. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. The Lancet Child & Adolescent Health 2017, 1(3): 184-194. 3. Bonsante F, Ramful D, Binquet C, Samperiz S, Daniel S, Gouyon J-B, et al. Low Renal Oxygen Saturation at Near-Infrared Spectroscopy on the First Day of Life Is Associated with Developing Acute Kidney Injury in Very Preterm Infants. Neonatology 2019, 115(3): 198-204. 4. Mintzer JP, Moore JE. Regional tissue oxygenation monitoring in the neonatal intensive care unit: evidence for clinical strategies and future directions. Pediatr Res 2019, 86(3): 296-304. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuepXjb_IhrxXki3x2ronR6TuelR-JmioOJ32q-MMpkgQSMm-9EqU-18DqmZ5m9rReY | |||||||
| 26/11/2019 | Human Oncology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Evaluating therapeutic interactions between radiation therapy and immunotherapies: Perform preclinical lab research using in vitro and in vivo methodologies. https://www.humonc.wisc.edu/team_member/zachary-morris-md-phd/#research ____________________________________________________________________________ Role - Translational laboratory research; IRB Status - N/A; Skills - Basic laboratory skills | 2 | zmorris@humonc.wisc.edu | Zachary | Morris | MD/PhD | Zachary Morris, zmorris@humonc.wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.632.603 | Evaluating therapeutic interactions between radiation therapy and immunotherapies | Perform preclinical lab research using in vitro and in vivo methodologies. https://www.humonc.wisc.edu/team_member/zachary-morris-md-phd/#research | Translational laboratory research | Basic laboratory skills | N/A | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | • Grudzinski JJ, Hernandez R, Patel R, Marsh I, Sondel P, Morris ZS, Bednarz B, Weichert JP. Preclinical characterization of a new tumor-targeting APC-chelate, 86/90Y-NM600, in a variety of murine and human cancer tumor models. J. Nuc Med. Accepted March 2019. • Hernandez R, Walker KL, Grudzinski JJ, Aluicio-Sarduy E, Patel R, Zahm C, Pinchuk A, Massey C, Bitton A, Brown R, Engle JW, Sondel P, Morris ZS, Capitini CM, Weichert JP. 90Y-NM600 targeted radionuclide therapy achieves complete responses associated with immunologic memory in a syngeneic model of T-cell NHL. Communications Biology. Manuscript in Press. • Patel RB, Baniel CC, Sriramaneni RN, Bradley K, Markovina S, Morris ZS. Combining brachytherapy and immunotherapy to achieve in situ tumor vaccination: A review of cooperative mechanisms and clinical opportunities. Brachytherapy. 2018 Aug 2. pii: S1538-4721(18)30506-3. doi: 10.1016/j.brachy.2018.07.004. PMID: 30078541. • Morris ZS, Guy EI, Werner LR, Carlson PM, Heinze CM, Kler JS, Busche SM, Jaquish AA, Sriramaneni RN, Carmichael LL, Loibner H, Gillies SD, Korman AJ, Erbe AK, Hank JA, Rakhmilevich AL, Harari PM, Sondel PM. Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites. Cancer Immunol Res. 2018 Jul;6(7):825-834. doi: 10.1158/2326-6066.CIR-17-0353. PMID: 29748391. • Werner LR, Kler JS, Gressett MM, Riegert M, Werner LK, Heinze CM, Kern JG, Abbariki M, Erbe AK, Patel RB, Sriramaneni RN, Harari PM, Morris ZS. Transcriptional-mediated effects of radiation on the expression of immune susceptibility markers in melanoma. Radiother Oncol. 2017 Sep 8. pii: S0167-8140(17)32526-4. PMID: 28893414. • Morris ZS, Guy EI, Francis DM, Gressett MM, Werner LR, Carmichael LL, Yang RK, Armstrong EA, Huang S, Navid F, Gillies SD, Korman A, Hank JA, Rakhmilevich AL, Harari PM, Sondel PM. In situ tumor vaccination by combining local radiation and tumor-specific antibody or immunocytokine treatments. Cancer Research. 2016 Jul 1;76(13):3929-41. PMID: 27197149. | Yes | Raghava Sriramaneni sriramaneni@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud-2OP1VyG9lPyLhJrea0Yg1c2EQUMe1-m5isqvktqaHqJ9S16JBrYLEaYizYj1d5Y | ||||||||
| 27/11/2019 | Obstetrics & Gynecology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Black Maternal Morbidity: Patient Perspectives on Factors Associated with Health Disparities: This project will examine the black/white disparity in maternal morbidity and mortality at Meriter Hospital. The goal is to identify patient factors that contribute to the disparity by interviewing Black postpartum women who delivered at Meriter Hospital in 2019 with a severe morbidity. We will identify the common factors to develop interventions targeted at those factors. The second part of the study will be implementing these interventions to reduce the morbidity suffered by this population in hopes of decreasing the disparity. ____________________________________________________________________________ Role - We would like to enlist 1-2 Shapiro students who will assist with chart review and conduct patient interviews using a semi-structured survey during summer 2020.; IRB Status - In progress (at Meriter); Skills - Passion for health disparities, any skills with qualitative research (interviewing and data analysis) is helpful but not required | 0 | speace@uwhealth.org | Stephanie | Peace | MD, PGY-3 | Stephanie Peace, speace@uwhealth.org -- Co-Mentor: Kathryn Sarnoski, MD / Maya Gross, MD PGY-1 ksarnoski@wisc.edu / mgross2@uwhealth.org | Dr. | 3.149.102.668 | Kathryn Sarnoski, MD / Maya Gross, MD PGY-1 | ksarnoski@wisc.edu / mgross2@uwhealth.org | Obstetrics & Gynecology | Black Maternal Morbidity: Patient Perspectives on Factors Associated with Health Disparities | This project will examine the black/white disparity in maternal morbidity and mortality at Meriter Hospital. The goal is to identify patient factors that contribute to the disparity by interviewing Black postpartum women who delivered at Meriter Hospital in 2019 with a severe morbidity. We will identify the common factors to develop interventions targeted at those factors. The second part of the study will be implementing these interventions to reduce the morbidity suffered by this population in hopes of decreasing the disparity. | We would like to enlist 1-2 Shapiro students who will assist with chart review and conduct patient interviews using a semi-structured survey during summer 2020. | Moderate degree of independence for interviewing depending on the student's ability. | Passion for health disparities, any skills with qualitative research (interviewing and data analysis) is helpful but not required | In progress (at Meriter) | No | No (plan to use Dean's Office Funds) | Yes | MPH students | N/A | No | Kathryn Sarnoski, MD (faculty adviser) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc_J8UsaWg7ttC9TSFVNHmNXhFU1Z8MxgpXN5oR1WK0O-Azj4DCCl_vy65H_dwPzr0 | ||||
| 30/11/2019 | Anesthesiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Spinal cord stimulation for peripheral neuropathy: Our project will be focused on collecting data related to the efficacy of spinal cord stimulation in treating peripheral neuropathy. Spinal cord stimulator implants are performed in limited places in USA and UW is one of them. Peripheral neuropathy is one of the very challenging disease conditions that can be resistant to all medications and interventional procedures. We have patients where we placed spinal cord stimulators, and this led to excellent improvement in their pain. ____________________________________________________________________________ Role - Dtaa collection, manuscript writing; IRB Status - It should be illegible for exemption; Skills - Nothing special | 0 | abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MPH | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | Medical Director | 2.163.461.739 | Pain Medicine | Spinal cord stimulation for peripheral neuropathy | Our project will be focused on collecting data related to the efficacy of spinal cord stimulation in treating peripheral neuropathy. Spinal cord stimulator implants are performed in limited places in USA and UW is one of them. Peripheral neuropathy is one of the very challenging disease conditions that can be resistant to all medications and interventional procedures. We have patients where we placed spinal cord stimulators, and this led to excellent improvement in their pain. | Dtaa collection, manuscript writing | Nothing special | It should be illegible for exemption | No | Yes | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | None from our center | Yes | Laura Zitur, lzitur@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuccVFh76lolI8vBE2X_hKNGOlhNv3Lxnv5Q4NI9yQa8mKFBUiUL8yO-Y3Ur6pYEMWQ | |||||||
| 30/11/2019 | Anesthesiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | oral opioids reduction after intrathecal pump implant: The opioid epidemic has been a major issue in USA in the past few years. Opioids led and continue to lead to death of many Americans. We use intrathecal drug delivery systems which deliver microdoses of opioids intrathecally and by using them we were able to wean down chronic pain patients from their oral opioids. Based on literature, intrathecal opioids carry much less risk than oral opioids. We will work on collecting data from our implanted patients to find out the reduction in their oral opioids. Clinical shadowing will be available if the student wishes ____________________________________________________________________________ Role - Data collection, writing manuscript; IRB Status - We will qualify for an exemption; Skills - Commitment and good writing skills | 0 | abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MPH | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | Medical Director | 2.163.461.739 | Pain Medicine | oral opioids reduction after intrathecal pump implant | The opioid epidemic has been a major issue in USA in the past few years. Opioids led and continue to lead to death of many Americans. We use intrathecal drug delivery systems which deliver microdoses of opioids intrathecally and by using them we were able to wean down chronic pain patients from their oral opioids. Based on literature, intrathecal opioids carry much less risk than oral opioids. We will work on collecting data from our implanted patients to find out the reduction in their oral opioids. Clinical shadowing will be available if the student wishes | Data collection, writing manuscript | Commitment and good writing skills | We will qualify for an exemption | No | Yes | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Nothing published by UW yet | Yes | Laura Zitur, lzitur@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucCydR_TldJvwCSU_7wF3yDAd7OSlTLxWKE-FXd2__GvCInkiugPTBNMD265lPNces | |||||||
| 02/12/2019 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Periprosthetic fracture after primary THA- prediction and prevention: Retrospective review of all periprosthetic fractures (PPx) after primary THA. We will urilize our departmental database and coding information to identify all primary THAs during the study period (2000- present). We will then identify all patients with and without PPx. We will utilize statistical analysis to identify clinical and radiographic predictors of PPx and develop a predictive tool that may be used prospectively to identify at risk patients and reduce their risk of post op PPx after primary THA ____________________________________________________________________________ Role - Data gathering, IRB submission, data analysis, and manuscript preparation; IRB Status - Need to apply; Skills - Organized and analytical individual | 0 | illgen@ortho.wisc.edu | Richard | Illgen | MD | Richard Illgen, illgen@ortho.wisc.edu -- Co-Mentor: | Professor of Orthopedic Surgery | 608 | Periprosthetic fracture after primary THA- prediction and prevention | Retrospective review of all periprosthetic fractures (PPx) after primary THA. We will urilize our departmental database and coding information to identify all primary THAs during the study period (2000- present). We will then identify all patients with and without PPx. We will utilize statistical analysis to identify clinical and radiographic predictors of PPx and develop a predictive tool that may be used prospectively to identify at risk patients and reduce their risk of post op PPx after primary THA | Data gathering, IRB submission, data analysis, and manuscript preparation | Significant idenepnce would be expected but guidance and oversight will be provided | Organized and analytical individual | Need to apply | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | none | Yes | Erica Fry, Carolyn Morris | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudm-lgIzNU2f17BOBsdRD0yHJqeex1MAT79ytj6TLVBvDHVi5POPWp9hJ_kaAmMbL4 | |||||||
| 02/12/2019 | Neurology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Testing Effects of Diet on Neurological & Metabolic Outcomes in Mice: Research in the Westmark laboratory focuses on synaptic function as related to the over-expression of amyloid beta protein precursor (APP) and amyloid beta in fragile X syndrome. We hypothesize that therapeutic and dietary interventions that normalize APP and A levels will improve seizure, behavioral and cognitive phenotypes in fragile X. We are currently testing the effects of soy-based and ketogenic diets on neurological outcomes in Fmr1KO mice. This research has immense potential to have an impact on individuals with fragile X and their families as there is currently a dearth of potent therapeutics and it may be possible to alter the diet early in development for the treatment of the rare developmental disorder fragile X syndrome. Overall, these studies will advance our knowledge of the underlying neurobiology of fragile X and could provide novel biomarkers and targets for therapeutic intervention. ____________________________________________________________________________ Role - Conduct dosing, behavioral and biomarker studies in mice.; IRB Status - N/A; Skills - Enthusiasm. Willingness to work with rodents. | 1 | westmark@wisc.edu | Cara | Westmark | PhD | Cara Westmark, westmark@wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.629.730 | Testing Effects of Diet on Neurological & Metabolic Outcomes in Mice | Research in the Westmark laboratory focuses on synaptic function as related to the over-expression of amyloid beta protein precursor (APP) and amyloid beta in fragile X syndrome. We hypothesize that therapeutic and dietary interventions that normalize APP and A levels will improve seizure, behavioral and cognitive phenotypes in fragile X. We are currently testing the effects of soy-based and ketogenic diets on neurological outcomes in Fmr1KO mice. This research has immense potential to have an impact on individuals with fragile X and their families as there is currently a dearth of potent therapeutics and it may be possible to alter the diet early in development for the treatment of the rare developmental disorder fragile X syndrome. Overall, these studies will advance our knowledge of the underlying neurobiology of fragile X and could provide novel biomarkers and targets for therapeutic intervention. | Conduct dosing, behavioral and biomarker studies in mice. | No experience required. Will train to work independently. | Enthusiasm. Willingness to work with rodents. | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Preclinical Testing of the Ketogenic Diet in Fragile X Mice. Submitted for review. Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons. Front Nutr. 2017 Jan 18;3:59. doi: 10.3389/fnut.2016.00059. eCollection 2016. Soy Infant Formula may be Associated with Autistic Behaviors. Autism Open Access. 2013 Nov 18;3. pii: 20727. A hypothesis regarding the molecular mechanism underlying dietary soy-induced effects on seizure propensity. Front Neurol. 2014 Sep 3;5:169. doi: 10.3389/fneur.2014.00169. eCollection 2014. Soy infant formula and seizures in children with autism: a retrospective study. PLoS One. 2014 Mar 12;9(3):e80488. doi: 10.1371/journal.pone.0080488. eCollection 2014. Soy-based diet exacerbates seizures in mouse models of neurological disease. J Alzheimers Dis. 2013;33(3):797-805. doi: 10.3233/JAD-2012-121426. | Yes | Jenny Becker (becker@neurology.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufuM7E1PqGw5aUCfDchCeXwrKZQhePhdvVlfH-COcbrJxIuWbMhyHWrGR9PolFUpvQ | |||||||
| 03/12/2019 | Orthopedics and Rehabilitation | Research Electives for credit | The Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children: The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. Although prior research has almost exclusively evaluated the left ventricle (LV) at rest, the influences of cardiorespiratory fitness (CRF) and body composition on the right ventricle (RV) and the biventricular responses to exercise have not been explored. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy children, ages 12-14 years old, will be recruited for participation. Testing will include determination of height, weight, body composition by whole body MRI, and maximal oxygen consumption by cycle ergometry. Participants will undergo cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Variables will be initially compared across weight status (normal weight, overweight, obese) as well as across fitness level using a median split of VO2max relativized to fat-free mass (high, low). Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates. We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the RV and the ventricular response to exercise. Understanding how CRF and body composition interact to affect ventricular size and function will facilitate the development of subsequent longitudinal, interventional studies to undermine the development of cardiovascular disease. ____________________________________________________________________________ Role - Actively participate in participant recruitment, data collection (fitness testing and cardiac MRI), data analysis, and dissemination of findings.; IRB Status - Approved; Skills - Strong organizational skills, ability to interact with families and children, and work independently in data management and scientific writing | 0 | awatson281@gmail.com | Andrew | Watson | MD, MS | Andrew Watson, awatson281@gmail.com -- Co-Mentor: | Assistant Professor | 6.082.636.647 | Sports Medicine | The Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children | The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. Although prior research has almost exclusively evaluated the left ventricle (LV) at rest, the influences of cardiorespiratory fitness (CRF) and body composition on the right ventricle (RV) and the biventricular responses to exercise have not been explored. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy children, ages 12-14 years old, will be recruited for participation. Testing will include determination of height, weight, body composition by whole body MRI, and maximal oxygen consumption by cycle ergometry. Participants will undergo cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Variables will be initially compared across weight status (normal weight, overweight, obese) as well as across fitness level using a median split of VO2max relativized to fat-free mass (high, low). Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates. We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the RV and the ventricular response to exercise. Understanding how CRF and body composition interact to affect ventricular size and function will facilitate the development of subsequent longitudinal, interventional studies to undermine the development of cardiovascular disease. | Actively participate in participant recruitment, data collection (fitness testing and cardiac MRI), data analysis, and dissemination of findings. | Will be expected to assist with data collection and work independently with data management. Will be expected to contribute to abstract and manuscript preparation with guidance. | Strong organizational skills, ability to interact with families and children, and work independently in data management and scientific writing | Approved | Yes | Yes | Yes | PhD students, UW undergraduates interested in research | Haraldsdottir K, Watson AM, Beshish AG, Pegelow DF, Palta M, Tetri LH, Brix MD, Centanni, RM, Goss, KN, Eldridge MW. Heart Rate Recovery After Maximal Exercise Is Impaired in Healthy Young Adults Born Preterm. Eur J Appl Physiol 2019 (Epub Ahead of Print). Watson A, Coutinho C, Haraldsdottir K, Brickson S, Dunn W, Eldridge M. In-Season Changes in Ventricular Morphology and Systolic Function in Adolescent Female Athletes. Eur J Sports Sci 2018:534-540. Goss KN, Beshish AG, Barton GP, Haraldsdottir K, Levin TS, Tetri LH, Battiola TJ, Mulchrone AM, Pegelow DF, Palta M, Lamers LJ, Watson AM, Chesler NC, Eldridge MW. Early Pulmonary Vascular Disease in Young Adults Born Preterm. Am J Respir Crit Care Med. 2018 (ePub ahead of print). Haraldsdottir K, Watson AM, Goss KN, Beshish AG, Pegelow DF, Palta M, Tetri LH, Barton GP, Brix MD, Centanni RM, Eldridge MW. Impaired Autonomic Function in Adolescents Born Preterm. Phys Rep:2018;6:e13620. Goss KN, Haraldsdottir K, Beshish AG, Barton GP, Macdonald JA, Levin TS, Watson AM, Palta M, Chesler NC, Francois CJ, Wieben O, Eldridge MW. Biventricular inefficiency in adults born preterm. Circulation, under review. Haraldsdottir H, Watson AM, Pegelow DF, Palta M, Tetri LH, Levin TS, Brix MD, Centanni RM, Goss KN, Eldridge MM. Blunted cardiac exercise response in preterm children. Ped Research, under review. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf-Roq0jU96h8VVYRaRkels9X8qEdMBFDsvEdQ1DRr5CNk7kW4PTK7yXKKg6x0ImvY | ||||||
| 03/12/2019 | Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Patient-Doctor Decision Making in High-Stakes Decisions: My lab is focused on patient-doctor communication, primarily communication between surgeons and patients but also other clinicians who are making high-stakes decisions with patients who are older and have serious medical problems. Summer students have typically taken on in-progress research so as to have time to do analysis and presentation. Data collection is typically too time consuming for an 8-week project. Presently we are working on a secondary analysis of recorded conversations for a large multi-site trial, evaluating shared decision making and the content of communication. We also have other interventional studies in progress using our “best case/worst case” tool in the trauma ICU and with older patients considering dialysis. ____________________________________________________________________________ Role - Ideally I would like for our student to participate in all facets of the work we are doing. In addition, the student should aim to develop a contained project that leads to presentation at a regional or national surgical meeting. Degree of independence required We have a small team, students who are self-motivated will get more out of the experience, but there will be lots of help; IRB Status - Approved; Skills - None | 0 | schwarze@surgery.wisc.edu | Gretchen | Schwarze | MD, MPP | Gretchen Schwarze, schwarze@surgery.wisc.edu -- Co-Mentor: | Associate Professor | 608 | Vascular Surgery | Patient-Doctor Decision Making in High-Stakes Decisions | My lab is focused on patient-doctor communication, primarily communication between surgeons and patients but also other clinicians who are making high-stakes decisions with patients who are older and have serious medical problems. Summer students have typically taken on in-progress research so as to have time to do analysis and presentation. Data collection is typically too time consuming for an 8-week project. Presently we are working on a secondary analysis of recorded conversations for a large multi-site trial, evaluating shared decision making and the content of communication. We also have other interventional studies in progress using our “best case/worst case” tool in the trauma ICU and with older patients considering dialysis. | Ideally I would like for our student to participate in all facets of the work we are doing. In addition, the student should aim to develop a contained project that leads to presentation at a regional or national surgical meeting. Degree of independence required We have a small team, students who are self-motivated will get more out of the experience, but there will be lots of help | None | Approved | Yes | Yes | Yes | Not currently available to mentor other students | Will discuss | Yes | Sarah Pavao pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufBvFB1tqKto363-lrcJG97C3ngdEDCg7iszlMwsmpTFbLzH1T5Z873HuFdTCZvnb4 | |||||||
| 03/12/2019 | Surgery | Shorter term projects | Clinical Research in Surgical Oncology: The Division of Surgical Oncology has a breadth of clinical and basic science research experience and interest, and a track record of mentoring Shapiro students through a productive, high-yield summer. The gastrointestinal (GI) surgeons in our group who mentor students include Sharon Weber, Daniel Abbott, and Sean Ronnekleiv-Kelly. Our clinical research focuses on: 1) identifying and addressing disparities in the care of patients with GI cancer, especially for those suffering from socioeconomic and/or geographic disparities, 2) identifying actionable predictors of excessive cost and resource utilization, in an effort to improve the cost effective/resource wise care of our cancer patients, and 3) technologic interventions that can minimize readmission and increase patient adherence through transitions of care. Additionally, Dr. Ronnekleiv—Kelly runs a basic science lab, using genetically engineered mouse models of pancreas cancer to understand how the Per-Arnt-Sim family of environmental sensor proteins influence pancreatic cancer development and progression. Specifically, he is evaluating how circadian rhythm disruption promotes pancreas cancer development, spread and response to therapy, and how the aryl hydrocarbon receptor controls immune cells in the tumor microenvironment. Working with us would offer a Shapiro student several options for a research focus that can be tailored to the student’s interests. Skills that could be gained include the following: study design, background literature review, chart review, database management, quality improvement principles, qualitative analysis, statistical analysis, and abstract/manuscript preparation. The student would work directly with a full time surgery research resident, who would provide feedback and mentorship to compliment ongoing oversight of the project and mentorship from the faculty. ____________________________________________________________________________ Role - There are a variety of projects. Willing to discuss student interest and level of independence when meeting with mentors.; IRB Status - Depends upon Project; Skills - None | 0 | abbott@surgery.wisc.edu | Daniel | Abbott | MD | Daniel Abbott, abbott@surgery.wisc.edu -- Co-Mentor: Sharon Weber, MD, Professor | Associate Professor | 608 | Surgical Oncology | Sharon Weber, MD, Professor | Surgery | Surgical Oncology | Clinical Research in Surgical Oncology | The Division of Surgical Oncology has a breadth of clinical and basic science research experience and interest, and a track record of mentoring Shapiro students through a productive, high-yield summer. The gastrointestinal (GI) surgeons in our group who mentor students include Sharon Weber, Daniel Abbott, and Sean Ronnekleiv-Kelly. Our clinical research focuses on: 1) identifying and addressing disparities in the care of patients with GI cancer, especially for those suffering from socioeconomic and/or geographic disparities, 2) identifying actionable predictors of excessive cost and resource utilization, in an effort to improve the cost effective/resource wise care of our cancer patients, and 3) technologic interventions that can minimize readmission and increase patient adherence through transitions of care. Additionally, Dr. Ronnekleiv—Kelly runs a basic science lab, using genetically engineered mouse models of pancreas cancer to understand how the Per-Arnt-Sim family of environmental sensor proteins influence pancreatic cancer development and progression. Specifically, he is evaluating how circadian rhythm disruption promotes pancreas cancer development, spread and response to therapy, and how the aryl hydrocarbon receptor controls immune cells in the tumor microenvironment. Working with us would offer a Shapiro student several options for a research focus that can be tailored to the student’s interests. Skills that could be gained include the following: study design, background literature review, chart review, database management, quality improvement principles, qualitative analysis, statistical analysis, and abstract/manuscript preparation. The student would work directly with a full time surgery research resident, who would provide feedback and mentorship to compliment ongoing oversight of the project and mentorship from the faculty. | There are a variety of projects. Willing to discuss student interest and level of independence when meeting with mentors. | None | Depends upon Project | No | Yes | Yes | Not currently available to mentor other students | Will discuss at meeting | Yes | Sarah Pavao - pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufDm1yJWp3JILDEKcxx-J9WoujtXj65ePA_EcIwABTr6XenjA_PAnQ0Dztjuk4gVmI | ||||
| 03/12/2019 | Surgery | Shorter term projects | Basic Science Research in Surgical Oncology: The Division of Surgical Oncology has a breadth of clinical and basic science research experience and interest, and a track record of mentoring Shapiro students through a productive, high-yield summer. The gastrointestinal (GI) surgeons in our group who mentor students include Sharon Weber, Daniel Abbott, and Sean Ronnekleiv-Kelly. Our clinical research focuses on: 1) identifying and addressing disparities in the care of patients with GI cancer, especially for those suffering from socioeconomic and/or geographic disparities, 2) identifying actionable predictors of excessive cost and resource utilization, in an effort to improve the cost effective/resource wise care of our cancer patients, and 3) technologic interventions that can minimize readmission and increase patient adherence through transitions of care. Additionally, Dr. Ronnekleiv—Kelly runs a basic science lab, using genetically engineered mouse models of pancreas cancer to understand how the Per-Arnt-Sim family of environmental sensor proteins influence pancreatic cancer development and progression. Specifically, he is evaluating how circadian rhythm disruption promotes pancreas cancer development, spread and response to therapy, and how the aryl hydrocarbon receptor controls immune cells in the tumor microenvironment. Working with us would offer a Shapiro student several options for a research focus that can be tailored to the student’s interests. Skills that could be gained include the following: study design, background literature review, chart review, database management, quality improvement principles, qualitative analysis, statistical analysis, and abstract/manuscript preparation. The student would work directly with a full time surgery research resident, who would provide feedback and mentorship to compliment ongoing oversight of the project and mentorship from the faculty. ____________________________________________________________________________ Role - Will vary depending upon project. Will discuss options for research, role and independence at meeting; IRB Status - Depends upon the project; Skills - None | 0 | ronnekleiv-kelly@surgery.wisc.edu | Sean | Ronnekleiv-Kelly | MD | Sean Ronnekleiv-Kelly, ronnekleiv-kelly@surgery.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Surgical Oncology | Basic Science Research in Surgical Oncology | The Division of Surgical Oncology has a breadth of clinical and basic science research experience and interest, and a track record of mentoring Shapiro students through a productive, high-yield summer. The gastrointestinal (GI) surgeons in our group who mentor students include Sharon Weber, Daniel Abbott, and Sean Ronnekleiv-Kelly. Our clinical research focuses on: 1) identifying and addressing disparities in the care of patients with GI cancer, especially for those suffering from socioeconomic and/or geographic disparities, 2) identifying actionable predictors of excessive cost and resource utilization, in an effort to improve the cost effective/resource wise care of our cancer patients, and 3) technologic interventions that can minimize readmission and increase patient adherence through transitions of care. Additionally, Dr. Ronnekleiv—Kelly runs a basic science lab, using genetically engineered mouse models of pancreas cancer to understand how the Per-Arnt-Sim family of environmental sensor proteins influence pancreatic cancer development and progression. Specifically, he is evaluating how circadian rhythm disruption promotes pancreas cancer development, spread and response to therapy, and how the aryl hydrocarbon receptor controls immune cells in the tumor microenvironment. Working with us would offer a Shapiro student several options for a research focus that can be tailored to the student’s interests. Skills that could be gained include the following: study design, background literature review, chart review, database management, quality improvement principles, qualitative analysis, statistical analysis, and abstract/manuscript preparation. The student would work directly with a full time surgery research resident, who would provide feedback and mentorship to compliment ongoing oversight of the project and mentorship from the faculty. | Will vary depending upon project. Will discuss options for research, role and independence at meeting | None | Depends upon the project | No | Yes | Yes | Not currently available to mentor other students | Will discuss at meeting | No | Sarah Pavao - pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufNlt5_HHFlKLrI-06pQZaGe9tn42t55FCDTI3H8TMW7vY7Js1UqcmZeElu8osQjfI | |||||||
| 03/12/2019 | Surgery | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | consistency in inflow cannula position in patients who received LVAD via a non-sternotomy approach.: Left ventricular assist device (LVAD) is a surgical option for the treatment of patients with end stage heart failure. LVAD’s have standardly been implanted via a full sternotomy. Non-sternotomy approaches for LVAD implantation are gaining in popularity. Little has been studied regarding the potential benefits of non-sternotomy LVAD placement. This project will evaluate the consistency in inflow cannula position in patients who received LVAD via a non-sternotomy approach. ____________________________________________________________________________ Role - Data collection, data analysis, abstract / manuscript preparation and submission ; IRB Status - Approved. Ongoing; Skills - None necessary | 0 | fiedler@surgery.wisc.edu | Amy | Fiedler | MD, MS | Amy Fiedler, fiedler@surgery.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Cardiothoracic Surgery | consistency in inflow cannula position in patients who received LVAD via a non-sternotomy approach. | Left ventricular assist device (LVAD) is a surgical option for the treatment of patients with end stage heart failure. LVAD’s have standardly been implanted via a full sternotomy. Non-sternotomy approaches for LVAD implantation are gaining in popularity. Little has been studied regarding the potential benefits of non-sternotomy LVAD placement. This project will evaluate the consistency in inflow cannula position in patients who received LVAD via a non-sternotomy approach. | Data collection, data analysis, abstract / manuscript preparation and submission | Moderate | None necessary | Approved. Ongoing | No | No (plan to use Dean's Office Funds) | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Will discuss at meeting | Yes | Sarah Pavao - pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudoEJ1KVg9ODavny6BIOEjw9Omht3IPjr3UR7gl7h2xcEm0W8gEYWdhmDXwXQobv9I | ||||||
| 13/12/2019 | Pediatrics | Shorter term projects, Research Electives for credit | Medical Student Wellness : Use qualitative research methods known as concept mapping to investigate the question: What are the contributors to medical student burnout? ____________________________________________________________________________ Role - Student will receive orientation and instruction on how to perform the steps necessary for each aspect of the project. Student will then be responsible for managing each step of the project and reporting progress. During downtime of active research steps, student will perform literature reviews, develop an abstract and draft a manuscript, and perform work that supports other ongoing projects.; IRB Status - Needs to be completed ; Skills - Highly motivated in this topic, highly dependable, follows through, good communicator, responsive to feedback, solid writing skills, meets deadlines, willing to help in other areas as needed, kind, highly organized | 0 | babal@wisc.edu | Jess | Babal | MD | Jess Babal, babal@wisc.edu -- Co-Mentor: | Assistant Professor of Pediatrics | Medical Student Wellness | Use qualitative research methods known as concept mapping to investigate the question: What are the contributors to medical student burnout? | Student will receive orientation and instruction on how to perform the steps necessary for each aspect of the project. Student will then be responsible for managing each step of the project and reporting progress. During downtime of active research steps, student will perform literature reviews, develop an abstract and draft a manuscript, and perform work that supports other ongoing projects. | Will receive orientation and frequent instruction on project steps, will have model projects to follow, will have open door to collaborate and ask questions, and will also need to be highly motivated, dependable, and independent in completing work. | Highly motivated in this topic, highly dependable, follows through, good communicator, responsive to feedback, solid writing skills, meets deadlines, willing to help in other areas as needed, kind, highly organized | Needs to be completed | No | Through peds dept | Yes | Not currently available to mentor other students | Two projects in process in our department for resident and faculty wellness. Students can also search PubMed for “concept mapping” studies to learn about the technique. | Yes | Christine Richards (MPA), Bradley Kerr (GPAM research intern manager) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufthdG1G3qPUlsnwJziPr9ih5d8UjB5K72fRc65MlbXQqkl3U5ZnNNgczz_MHeFWKY | ||||||||
| 10/12/2019 | Emergency Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Machine Learning to Improve Emergency Medical Care for Older Adults: We are interested in using informatics-based approaches including machine learning and natural language processing to develop automated screening processes for older adult ED patients, with a current focus on fall risk. Falls among older adults are a major public health concern, with significant morbidity and mortality. Despite guidelines and quality measures, screening for fall risk remains inconsistent in the primary care setting. Emergency department (ED) patients are generally at higher risk of outpatient falls than the general population, making the ED an important additional setting to identify high risk patients. While guidelines recommend screening for fall risk in the ED, this practice has not been widely implemented for many reasons, including the effort burden of screening in the high intensity, high volume ED setting and limited availability of referrals for intervention. Despite previous efforts, no existing screening tools satisfy the need for a scalable, adaptable, and measurable instrument suitable for widespread implementation. One potential solution for increasing screening rates without requiring significant additional resources in the ED is through the development and implementation of an algorithm to screen patients using information present in the electronic health record (EHR) at the time of an ED visit. We have developed such an algorithm using machine learning techniques. We have additionally modified current nurse screening algorithms to ask additional fall risk questions, and are interested in the predictive ability of these questions. We are in the process of implementing an automated falls screening program at UWhealth and have a variety of projects amenable to a shapiro summer program, ranging from implementation evaluation of our current algorithms to more technical work on development of future algorithm targets. ____________________________________________________________________________ Role - Data analysis, abstract and manuscript development and preparation. I would expect a first author national presentation with the opportunity for authorship of the resultant manuscript. ; IRB Status - Some of our work is quality improvement, the rest is already IRB approved; Skills - Some technical program backgroud (we use python for most of our analyses) is preferred but not necessary | 1 | bpatter@medicine.wisc.edu | Brian | Patterson | MD MPH | Brian Patterson, bpatter@medicine.wisc.edu -- Co-Mentor: | Assistant Professor | 3.126.366.957 | Machine Learning to Improve Emergency Medical Care for Older Adults | We are interested in using informatics-based approaches including machine learning and natural language processing to develop automated screening processes for older adult ED patients, with a current focus on fall risk. Falls among older adults are a major public health concern, with significant morbidity and mortality. Despite guidelines and quality measures, screening for fall risk remains inconsistent in the primary care setting. Emergency department (ED) patients are generally at higher risk of outpatient falls than the general population, making the ED an important additional setting to identify high risk patients. While guidelines recommend screening for fall risk in the ED, this practice has not been widely implemented for many reasons, including the effort burden of screening in the high intensity, high volume ED setting and limited availability of referrals for intervention. Despite previous efforts, no existing screening tools satisfy the need for a scalable, adaptable, and measurable instrument suitable for widespread implementation. One potential solution for increasing screening rates without requiring significant additional resources in the ED is through the development and implementation of an algorithm to screen patients using information present in the electronic health record (EHR) at the time of an ED visit. We have developed such an algorithm using machine learning techniques. We have additionally modified current nurse screening algorithms to ask additional fall risk questions, and are interested in the predictive ability of these questions. We are in the process of implementing an automated falls screening program at UWhealth and have a variety of projects amenable to a shapiro summer program, ranging from implementation evaluation of our current algorithms to more technical work on development of future algorithm targets. | Data analysis, abstract and manuscript development and preparation. I would expect a first author national presentation with the opportunity for authorship of the resultant manuscript. | High independence- I will generally have weekly individual mentoring meetings with students, and there are opportunities for group mentoring through lab meetings and other collaborations | Some technical program backgroud (we use python for most of our analyses) is preferred but not necessary | Some of our work is quality improvement, the rest is already IRB approved | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | see: https://scholar.google.com/citations?hl=en&user=sczIA0cAAAAJ&view_op=list_works&sortby=pubdate | Yes | n/a | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf61gGRhgDH0fBo_NpAd4ijm3S-YDvgM9QC_oRAwty2zSirl6fS2dJcOUngdTHWqak | |||||||
| 12/01/2020 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Assessing cancer patient access and use of the patient health portals: This project is designed to help us understand cancer patient utilization of MyChart including predictors of who, how, what, when and why. There is a variety of conflicting information, largely anecdotally about adoption (or lack of adoption) surrounding patient health portals (e.g. MyChart) for patients with chronic disease. Among patients with chronic health conditions, cancer patients stand out as a specific group for further study, particularly because use of patient health portals raises concerns about potential harm if information is shared outside of clinical situations where patients can readily address concerns. This project will assess patients seen at the UW Carbone Cancer Center and examine presence of an account, usage of the account and associated factors that may or may not correlate. A particular focus on rural vs urban disparities in portal usage is anticipated. ____________________________________________________________________________ Role - The student will be responsible for primary data analysis, literature review and manuscript preparation. S/he will be co-mentored by a medical oncologist and a human factors engineer, with the opportunity to spend time in cancer clinics, and participate in generation and analysis of EHR data, as well as to participate in publication of a manuscript.; IRB Status - This project is IRB exempt; Skills - Basic statistical skills -- one of the co-mentors (Dr Sesto) will be available for additional support; ability to use reference software & conduct a literature review, as well as solid writing skills | 0 | tevaarwerk@wisc.edu | Amye | Tevaarwerk | MD | Amye Tevaarwerk, tevaarwerk@wisc.edu -- Co-Mentor: Mary Sesto, Assoc Professor msesto@wisc.edu | Associate Professor | 608 | Hematology/Oncology | Mary Sesto, Assoc Professor | msesto@wisc.edu | Medicine | Hematology Oncology | Assessing cancer patient access and use of the patient health portals | This project is designed to help us understand cancer patient utilization of MyChart including predictors of who, how, what, when and why. There is a variety of conflicting information, largely anecdotally about adoption (or lack of adoption) surrounding patient health portals (e.g. MyChart) for patients with chronic disease. Among patients with chronic health conditions, cancer patients stand out as a specific group for further study, particularly because use of patient health portals raises concerns about potential harm if information is shared outside of clinical situations where patients can readily address concerns. This project will assess patients seen at the UW Carbone Cancer Center and examine presence of an account, usage of the account and associated factors that may or may not correlate. A particular focus on rural vs urban disparities in portal usage is anticipated. | The student will be responsible for primary data analysis, literature review and manuscript preparation. S/he will be co-mentored by a medical oncologist and a human factors engineer, with the opportunity to spend time in cancer clinics, and participate in generation and analysis of EHR data, as well as to participate in publication of a manuscript. | High | Basic statistical skills -- one of the co-mentors (Dr Sesto) will be available for additional support; ability to use reference software & conduct a literature review, as well as solid writing skills | This project is IRB exempt | No | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students | This project is part of our larger research efforts examine how to leverage EHRs and other health information technology (IT) to better support the care of cancer patients. Our multiple publications on this topic are available on Pubmed or by following this link on NCBI: https://www.ncbi.nlm.nih.gov/myncbi/amye.tevaarwerk.1/bibliography/public/ | Yes | Julene Gaspard | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudHXfaiObsjpG_pCxn7nE1qDFoNC3RnqSmfzkhYHeT03dgs6xAQPN2EurpENKxUgWw | ||
| 12/01/2020 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Symptoms reported and services needed by breast cancer patients seen for a survivorship care planning visit: This project is designed to help us understand cancer survivor utilization of supportive services following the end of active therapy. There is a variety of conflicting information, suggesting that symptom burden is high. Prior analysis early in the process of collecting information about breast cancer survivor symptoms and referral suggested that while many reported symptoms, the desire for information or intervention was low. We will use an EHR data pull to assess over 4 years of data, assess breast cancer survivor receipt of survivorship care planning, examine the frequency of reported symptoms vs information requests vs referrals, and look for associated predictors of receipt of care planning and need for referrals. ____________________________________________________________________________ Role - The student(s) will be responsible for primary data analysis, literature review and manuscript presentation. S/he will be co-mentored by a medical oncologist and a human factors engineer, with the opportunity to spend time in cancer clinics, and participate in analysis of EHR data.; IRB Status - Exempt; Skills - Basic statistical skills -- one of the co-mentors (Dr Sesto) will be available for additional support; ability to use reference software & conduct a literature review, as well as solid writing skills | 0 | tevaarwerk@wisc.edu | Amye | Tevaarwerk | MD | Amye Tevaarwerk, tevaarwerk@wisc.edu -- Co-Mentor: Mary Sesto, Assoc Professor msesto@wisc.edu | Associate Professor | 608 | Hematology/oncology | Mary Sesto, Assoc Professor | msesto@wisc.edu | Medicine | Hematology/oncology | Symptoms reported and services needed by breast cancer patients seen for a survivorship care planning visit | This project is designed to help us understand cancer survivor utilization of supportive services following the end of active therapy. There is a variety of conflicting information, suggesting that symptom burden is high. Prior analysis early in the process of collecting information about breast cancer survivor symptoms and referral suggested that while many reported symptoms, the desire for information or intervention was low. We will use an EHR data pull to assess over 4 years of data, assess breast cancer survivor receipt of survivorship care planning, examine the frequency of reported symptoms vs information requests vs referrals, and look for associated predictors of receipt of care planning and need for referrals. | The student(s) will be responsible for primary data analysis, literature review and manuscript presentation. S/he will be co-mentored by a medical oncologist and a human factors engineer, with the opportunity to spend time in cancer clinics, and participate in analysis of EHR data. | High | Basic statistical skills -- one of the co-mentors (Dr Sesto) will be available for additional support; ability to use reference software & conduct a literature review, as well as solid writing skills | Exempt | No | No (plan to use Dean's Office Funds) | Yes | DPT students, Genetic Counseling students, MPH students, PhD students | This project is part of our larger research efforts examine how to leverage EHRs and other health information technology (IT) to better support the care of cancer patients. Our multiple publications on this topic are available on Pubmed or by following this link on NCBI: https://www.ncbi.nlm.nih.gov/myncbi/amye.tevaarwerk.1/bibliography/public/ | Yes | Julene Gaspard | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudSoydgzc1Z5GA04xy_CDQoU8_pXLS_le1bBZsBm7NBwfSZl996IE0LVQoOpFZSg8o | ||
| 10/12/2019 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Identifying the role of Genicular Nerve block and Radiofrequency ablation in non-surgical candidates with primary knee osteoarthritis.: Total Knee arthroplasty is an effective treatment for patients with severe osteoarthritis of the knee However, patients with contraindications or who are poor candidates for surgery (those with BMI > 40) are faced with limited options as less invasive treatments provide little relief. Common non-surgical treatments include Non-Steroidal anti-inflammatory medications, corticosteroid injections and viscosupplementation. Another less known option is a Genicular nerve block and radiofrequency ablation. A procedure which has shown promise in the management of osteoarthritis related knee pain. Studies have shown that blocking the genicular nerves leads to both pain reduction and functional improvement in patients with severe osteoarthritis of the knee. However, larger studies are needed as sample size has been small and patient populations have been limited. We are conducting a prospective study to compare functional outcomes and pain scores from patients referred from a community setting with primary knee OA and patients referred from our non-surgical osteoarthritis clinic who have been referred for genicular nerve blocks ____________________________________________________________________________ Role - Chart review, compiling data, poster creation, with the ultimate goal of publication in a peer reviewed journal ; IRB Status - IRB approved ; Skills - students must be teachable and willing to learn | 0 | poliak@rehab.wisc.edu | Michelle | Poliak-Tunis | MD | Michelle Poliak-Tunis, poliak@rehab.wisc.edu -- Co-Mentor: Matthew Cowling mcowling@uwhealth.org | Attending Physician, Pain Medicine Program Director | Other | Pain Medicine | Matthew Cowling | mcowling@uwhealth.org | Orthopedics and Rehabilitation | Identifying the role of Genicular Nerve block and Radiofrequency ablation in non-surgical candidates with primary knee osteoarthritis. | Total Knee arthroplasty is an effective treatment for patients with severe osteoarthritis of the knee However, patients with contraindications or who are poor candidates for surgery (those with BMI > 40) are faced with limited options as less invasive treatments provide little relief. Common non-surgical treatments include Non-Steroidal anti-inflammatory medications, corticosteroid injections and viscosupplementation. Another less known option is a Genicular nerve block and radiofrequency ablation. A procedure which has shown promise in the management of osteoarthritis related knee pain. Studies have shown that blocking the genicular nerves leads to both pain reduction and functional improvement in patients with severe osteoarthritis of the knee. However, larger studies are needed as sample size has been small and patient populations have been limited. We are conducting a prospective study to compare functional outcomes and pain scores from patients referred from a community setting with primary knee OA and patients referred from our non-surgical osteoarthritis clinic who have been referred for genicular nerve blocks | Chart review, compiling data, poster creation, with the ultimate goal of publication in a peer reviewed journal | students must be teachable and willing to learn | IRB approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | 1.Choi, W., Hwang, S., Song, J., Leem, J., Kang, Y., Park, P., & Shin, J. (n.d.). Radiofrequency treatment relieves chronic knee osteoarthritis pain: A double-blind randomized controlled trial. Pain., 152(3), 481-487. 2.Kesikburun, S., Yaşar, E., Uran, A., Adigüzel, E., & Yilmaz, B. (2016). Ultrasound-Guided Genicular Nerve Pulsed Radiofrequency Treatment For Painful Knee Osteoarthritis: A Preliminary Report. Pain Physician : Official Journal of the Association of Pain Management Anesthesiologists., 19(5), E751-E759. 3.Lützner, J., Lange, T., Schmitt, C., Kopkow, M., Aringer, E., Böhle, H., . . . Gromnica-Ihle. (n.d.). [The S2k guideline: Indications for knee endoprosthesis : Evidence and consent-based indications for total knee arthroplasty]. Der Orthopäde., 47(9), 777-781. 4.Powell A, Teichtahl AJ, Wluka AE, et alObesity: a preventable risk factor for large joint osteoarthritis which may act through biomechanical factorsBritish Journal of Sports Medicine 2005;39:4-5. 5.Protzman, N., Gyi, J., Malhotra, A., & Kooch, J. (n.d.). Examining the feasibility of radiofrequency treatment for chronic knee pain after total knee arthroplasty. PM & R : The Journal of Injury, Function, and Rehabilitation., 6(4), 373-376. 6.Yuanyuan Wang, Andrew J Teichtahl, Jean-Pierre Pelletier, François Abram, Anita E Wluka, Sultana Monira Hussain, Johanne Martel-Pelletier, Flavia M Cicuttini, Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the Osteoarthritis Initiative, Rheumatology, Volume 58, Issue 2, February 2019, Pages 246–253, https://doi.org/10.1093/rheuma | Yes | Delilah Kowalke | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucWNQSWu3zMGrtwvZGRDXNza2U7j329jSl6iuxzRxl_kYl9ePBv-9H4leaEx09cXOg | ||||
| 20/12/2019 | Orthopedics and Rehabilitation | Shorter term projects, Research Electives for credit | UW Orthopedics Youth Knee Injury Registryistry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. ____________________________________________________________________________ Role - 1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production; IRB Status - HS-IRB 2019-0028 - Approved; Skills - Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents | 0 | McGuine@ortho.wisc.edu | Tim | McGuine | PhD | Tim McGuine, McGuine@ortho.wisc.edu -- Co-Mentor: Pamela Lang MD PLang@ortho.wisc.edu | Distinguished Scientist | 608 | Sports Medicine | Pamela Lang MD | PLang@ortho.wisc.edu | Orthopedics and Rehabilitation | UW Orthopedics Youth Knee Injury Registryistry | The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. | 1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production | Moderate | Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents | HS-IRB 2019-0028 - Approved | No | Yes | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | McGuine TA, Pfaller A, Kliethermes S, Schwarz A, Hetzel S, Hammer E, Broglio S. The effect of sport-related concussion injuries on concussion symptoms and health-related quality of life in male and female adolescent athletes: a prospective study. Am J Sports Med. 2019;47(14):3514–3520 DOI: 10.1177/0363546519880175 Kijowski R, Thurlow P, Blankenbaker D, Liu F, McGuine TA, Li G, Tuite M. Preoperative MRI Shoulder Findings Associated with Clinical Outcome 1 Year after Rotator Cuff Repair. Radiology. 2019 Apr 23;291(3):722-9. McGuine TA, Post EG, Hetzel, S, Pfallar A, Brooks MA, Bell D. A Prospective Study on the Impact of Sport Specialization on Lower Extremity Injury Rates in High School Athletes. American Journal of Sports Medicine. doi.org/10.1177/0363546517710213 McGuine TA, Hetzel S, Carr K, Winterstein A. Changes in Health-Related Quality of Life and Knee Function After Knee Injury in Young Female Athletes." Orthopedic Journal of Sports Medicine. 2.4 2014: DOI: 2325967114530988. Winterstein A, McGuine TA, Hetzel S, Carr K. Changes in Self-reported Physical Activity Following Knee Injury in Active Females. Athletic Training and Sports Health Care. 2013 5(3):106-114. McGuine TA, Hetzel S, Pennuto T, Brooks MA. Basketball Coaches' Utilization of Ankle Injury Prevention Strategies Sports Health: A Multidisciplinary Approach 2013;5(5):410-416. McGuine TA, Winterstein A, Carr K, Hetzel S, Scott J. Changes in Self-Reported Knee Function and Health-Related Quality of Life After Knee Injury in Female Athletes. Clinical Journal of Sports Medicine 2012; 22(4):334-340. Kijowski R, Sanago M, Lee K, Munoz del Rio A, McGuine TA, Baer G, Graf BK, De Smet AA. Short-term Clinical Importance of Osseous Injuries Diagnosed at MR Imaging in Patients with Anterior Cruciate Ligament Tear. Radiology. 2012; 264 (2): 531-541. Kijowski R, Woods MA, McGuine TA, Wilson JJ, Graf BK, De Smet AA. Arthroscopic partial meniscectomy: MR imaging for prediction of outcome in middle-aged and elderly patients. Radiology. 2011: 259(1);203-212. | Yes | Heidi Ableidinger (Ableidinger@ortho.wisc.edu); Emily Kay Koresh (ekoresh@wisc.edu); Liana Nash (Nash@ortho.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud-cQdhJmHlXEWPs6dqS2CGvUUuPkizNN5OAeayRuRvS6ZL-GrLr4suSjSAyUXwyy0 | |||
| 13/12/2019 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Bias Reduction in Internal Medicine (BRIM): The United States has been working towards increasing the diversity of the physician workforce for decades. Despite earnest efforts to achieve this, we have yet to see the physician workforce reflect the United States population, particularly at the leadership levels. A number of august bodies including the NIH, AAMC, AAAS, and APM have come to the conclusion that implicit bias is the likely cause for this lack of representation. The Bias Reduction in Internal Medicine (BRIM) Initiative is an NIH-funded, multi-site trial of an educational intervention in the form of a 3-hour workshop intended to reduce the impact of implicit bias and improve department climate. Nineteen departments of medicine around the United States are involved in this cluster randomized study. Subspecialty division in each department of medicine are randomized to receive this workshop early (Group 1) or later (Group 2). A group of up to 10 BRIM Implementers are trained at each site via a web-based course over 3 months. During this time, Group 2 serves as waitlist control. The BRIM Implementers deliver the workshop to divisions in Group 2. Data is collected via online surveys at baseline, 3 months after the Group 1 workshops, and approximately 3 months after the Group 2 workshops. We are currently in the third year of BRIM; sites are at different phases of the study. Students will be immersed in the multiple moving parts of a real world cluster randomized study. They will learn elements of study design in which data is collected at the individual level with randomization at the group level. They will assist with: 1) processing and creating summary documents from both written “commitments to action” and evaluation forms collected from each workshop participant, 2) analyzing responses to open-ended questions in the surveys, and 3) compiling survey data to create sections of the department climate reports provided to each site. ____________________________________________________________________________ Role - The Shapiro student would complete CITI Human Subjects training, if they have not already done so. They will may assist with processing of post-workshop data including a commitment to action summary, a summary of evaluations, qualitative analyses of responses to open-ended survey questions, preparation of climate reports, and providing technology support for online trainings. The Shapiro student will need to work from the Center for Women’s Health Research where all the data is stored. We will provide students a curated list of readings on the trial of the Breaking the Bias Habit, the influence of cultural stereotypes on judgment and decision-making within medicine, and qualitative research methods. The student will work closely with Amy Filut, who is currently a PhD Candidate planning to graduate in May 2020. They will participate in monthly BRIM Team meetings, check-in with Amy on a weekly basis, and have regular meetings with Dr. Molly Carnes, the PI of BRIM. ; IRB Status - Approved; Skills - Attention to detail in entering data, time management skills, interpersonal skills, experience with qualitative methods or willingness to learn these methods under the guidance of a mentor. | 0 | mlcarnes@wisc.edu | Molly | Carnes | MD, MS | Molly Carnes, mlcarnes@wisc.edu -- Co-Mentor: Amy Filut filut@wisc.edu | Professor and Director, Center for Women's Health Research | 6.082.639.770 | Center for Women's Health Research | Amy Filut | filut@wisc.edu | Bias Reduction in Internal Medicine (BRIM) | The United States has been working towards increasing the diversity of the physician workforce for decades. Despite earnest efforts to achieve this, we have yet to see the physician workforce reflect the United States population, particularly at the leadership levels. A number of august bodies including the NIH, AAMC, AAAS, and APM have come to the conclusion that implicit bias is the likely cause for this lack of representation. The Bias Reduction in Internal Medicine (BRIM) Initiative is an NIH-funded, multi-site trial of an educational intervention in the form of a 3-hour workshop intended to reduce the impact of implicit bias and improve department climate. Nineteen departments of medicine around the United States are involved in this cluster randomized study. Subspecialty division in each department of medicine are randomized to receive this workshop early (Group 1) or later (Group 2). A group of up to 10 BRIM Implementers are trained at each site via a web-based course over 3 months. During this time, Group 2 serves as waitlist control. The BRIM Implementers deliver the workshop to divisions in Group 2. Data is collected via online surveys at baseline, 3 months after the Group 1 workshops, and approximately 3 months after the Group 2 workshops. We are currently in the third year of BRIM; sites are at different phases of the study. Students will be immersed in the multiple moving parts of a real world cluster randomized study. They will learn elements of study design in which data is collected at the individual level with randomization at the group level. They will assist with: 1) processing and creating summary documents from both written “commitments to action” and evaluation forms collected from each workshop participant, 2) analyzing responses to open-ended questions in the surveys, and 3) compiling survey data to create sections of the department climate reports provided to each site. | The Shapiro student would complete CITI Human Subjects training, if they have not already done so. They will may assist with processing of post-workshop data including a commitment to action summary, a summary of evaluations, qualitative analyses of responses to open-ended survey questions, preparation of climate reports, and providing technology support for online trainings. The Shapiro student will need to work from the Center for Women’s Health Research where all the data is stored. We will provide students a curated list of readings on the trial of the Breaking the Bias Habit, the influence of cultural stereotypes on judgment and decision-making within medicine, and qualitative research methods. The student will work closely with Amy Filut, who is currently a PhD Candidate planning to graduate in May 2020. They will participate in monthly BRIM Team meetings, check-in with Amy on a weekly basis, and have regular meetings with Dr. Molly Carnes, the PI of BRIM. | The student will be well oriented to the project and environment at the Center for Women's Health Research and supervision will be immediately accessible. However, once oriented to a task that is part of the BRIM study, we will expect the student to function independently. | Attention to detail in entering data, time management skills, interpersonal skills, experience with qualitative methods or willingness to learn these methods under the guidance of a mentor. | Approved | Yes | Department of Medicine covers the 50% Shapiro summer student's stipend | Yes | MPH students, UW undergraduates interested in research | 1. Isaac C*, Byars-Winston A, McSorley R*, Schultz A*, Kaatz A*, Carnes M. A qualitative study of work-life choices in academic internal medicine. Adv Health Sci Educ Theory Pract. 2014; 19(1):29-41. PMID: 23605099. PMCID: PMC3938325 2. Kaatz A, Carnes M. Stuck in the Out-Group: Jennifer can’t grow up, Jane’s invisible, and Janet’s over the hill. J Women’s Health 2014; 23(6):1-4. PMID: 24844292. PMCID: PMC4046346. doi: 10.1089/jwh.2014.4766 3. Kolehmainen C*, Brennan M*, Filut A*, Isaac C*, Carnes M. Afraid of being “witchy with a ‘B’”: A qualitative study of how residents enact leadership in cardiopulmonary resuscitation. Acad Med 2014; 89:9, 1-6. PMID: 24979289. PMCID: PMC4146658. doi: 10.1097/ACM.0000000000000372 4. Kaatz A, Gutierrez B*, Carnes M. Threats to objectivity in peer review: The case of gender. Trends in Pharmacological Sciences, Science & Society 2014; 35:8, 371-373. http://dx.doi.org/10.1016/j.tips.2014.06.005 PMID: 25086743. PMCID: PMC4552397 5. Fine E, Wendt A, Carnes M. Gendered Expectations: Are we unintentionally undermining our efforts to diversify STEM fields. Crossroads. Summer 2014 Vol. 20 No. 4: 46-51 6. Gutierrez B*†, Kaatz A†, Chu S*, Ramirez D*, Samson-Samuel C*, Carnes M. Fair Play: A video game designed to address implicit race bias through active perspective taking. Games for Health Journal 2014, 3(6):371-378. PMID: 26192644 PMCID: PMC4559151. doi:10.1089/g4h.2013.0071. (†Dual first authors, contributed equally) 7. Kaatz A*, Magua W*, Zimmerman DR, Carnes M. A quantitative linguistic analysis of NIH R01 application critiques from investigators at one institution. Acad Med 2015;90(1):69-75. PMID: 25140529 PMCID:PMC4280285 8. Carnes M, Devine PG, Manwell LB, Byars-Winston A, Fine E, Ford CE, Forscher P*, Isaac C*, Kaatz A*, Magua W*, Palta M, Sheridan J. Effect of an intervention to break the gender bias habit: A cluster randomized, controlled trial. Acad Med. 2015;90(1): 221–230 PMID:25374039 PMCID: PMC4310758. doi: 10.1097/ACM.0000000000000552 9. Carnes M, Bartels C, Isaac C, Kaatz A, Kolehmainen C. Why is John more likely to become department chair than Jennifer? American Clinical and Climatological Society 2015; 126:197-214. PMID: 26330674. PMCID: PMC453068 10. Kolehmainen C, Stahr A, Kaatz A, Cook J, Carnes M. Post-code PTSD symptoms in internal medicine residents who participate in cardiopulmonary resuscitation events: A mixed methods study. J Graduate Medical Education 2015; 7(3): 475-479. PMID: 26457160. PMCID: PMC4597965.doi: 10.4300/JGME-D-14-00424.1 11. Kaatz, A., Carnes, M. Women at the top: The risks of leading from a glass cliff. Society for Cell Biology 2015; Jan/Feb: 42-44. PMID: 26457160; PMCID: PMC459796. 12. Carnes M, Vogelman B. Examining the potential benefits and harms of accreditation. J Women’s Health 2015; 24(5):doi: 10.1089/jwh.2015.5289 2015 May;24(5):341-8. doi: 10.1089/jwh.2015.5289. Epub 2015 Apr 28. PMID: 25919589. PMCID: PMC4440995. 13. Sheehy A, Kolehmainen C, Carnes M. We specialize in change leadership: A call for Hospitalists to lead the quest for workforce gender equity. Journal of Hospital Medicine. 2015; 10(8) 551–2. 14. Pier E L*, RaclawJ*, Nathan MJ, Kaatz A, Carnes M, & Ford C E. Studying the study section: How group decision making in person and via videoconferencing affects the grant peer review process. 2015. WCER Working Paper No. 2015-6. Retrieved from University of Wisconsin–Madison, Wisconsin Center for Education Research website: http://www.wcer.wisc.edu/publications/workingPapers/papers.php (†Dual first authors, contributed equally). 15. Kaatz A, Dattalo M*, Regner C*, Filut A*, Carnes M. Patterns of feedback on the bridge to independence: A qualitative thematic analysis of NIH Mentored Career Development Award application critiques. J Women’s Health 2016; 25(1): 78-90. PMID: 26418619. PMCID: PMC4741200. doi: 10.1089/jwh.2015.5254 16. Kaatz, A, Lee, Y-G, Potvien A, Magua W, Filut A*, Bhattacharaya A*, Leatherberry R, Zhu Xiaojin, Carnes M. Analysis of NIH R01 application critiques, impact and criteria scores: Does the sex of the principal investigator make a difference? Acad Med. 2016; 91(8):1080-8. PMID: 27276003. PMCID: PMC4965296. doi: 10.1097/ACM.0000000000001272 17. Sheridan J, Carnes M. Gender bias: how to break the habit. American Society for Cell Biology Newsletter, September 2, 2016. 18. Carnes M, Johnson P, Klein W, Jenkins M, Bairey Merz N. Carnes M, Johnson P, Klein W, Jenkins M, Bairey Merz N. Advancing women's health and women's leadership with endowed chairs in women's health. Acad Med. 2017;92(2):167-174. PMID: 27759706. PMCID: PMC547343. doi: 10.1097/ACM.0000000000001423 19. Sheridan, J., Savoy, J. N., Kaatz, A., Lee, Y.-G., Filut, A., & Carnes, M. Write more articles, get more grants: The impact of department climate on faculty research productivity. J Women’s Health. 2017; 26(5): 585-596. PMID: 28375751 PMCID: PMC5446612. doi:10.1089/jwh.2016.6022 20. Pier EL*, Raclaw J*, Kaatz A, Brauer M, Carnes M, Nathan MJ, Ford CE. ‘Your comments are meaner than your score’: Score Calibration Talk influences inter-panel variability during scientific grant peer review. Research Evaluation. 2017; 26(1):1-14. PMID: 28458466 PMCID: PMC5407376. doi: 10.1093/reseval/rvw025 21. Carnes M, Bairey-Merz CN. Women are less likely than men to be full professors in cardiology: Why does this happen and how can we fix it? Circulation. 2017;135:518-520. PMID: 28153988 PMCID: PMC5302849. doi: 10.1161/CIRCULATIONAHA.116.026671 22. Magua, W*., Zhu, X., Bhattacharya, A*., Filut, A.*, Potvien, A*., Leatherberry, R., Lee, Y. G., Jens, M., Malikireddy, D*., Carnes, M., & Kaatz, A. Are female applicants disadvantaged in National Institutes of Health peer review? Combining algorithmic text mining and qualitative methods to detect evaluative differences in R01 reviewers' critiques. J Women's Health. 2017; 26(5):560-570 PMID: 28281870 PMCID: PMC5446598.doi: 10.1089/jwh.2016.6021 23. Kaatz A, Carnes M, Gutierrez B*, Savoy J, Samuel C*, Filut A*, Pribbenow CM. Fair Play: A study of scientific workforce trainers’ experience playing an educational videogame about racial bias. CBE Life Sci Educ. 2017; Summer;16(2). pii: ar27. PMID: 28450447 PMCID: PMC5459245. doi: 10.1187/cbe.15-06-0140 24. Brindis CD, Freund KM, Baether-Lind L, Bairey Merz CN, Carnes M, Gulati M, Joffe H, Klein WS, Mazure LE, Regensteiner JG, Redberg RF, Wenger NK, Younger L. The risk of remaining silent: Addressing the current threats to women's health. Women’s Health Issues. 2017; 27-6:621-624. PMID: 29150088. doi:10.1016/j.whi.2017.10.006 25. Devine PG, Forscher PS*, Cox WTL*, Kaatz A, Sheridan J, and Carnes M. A gender bias habit-breaking intervention led to increased hiring of female faculty in STEMM departments. J Exp Soc Psychol 2017; 73:211-215. PMID: 29249837. PMCID: PMC5729935. doi: 10.1016/j.jesp.2017.07.002 26. Geller SE, Koch AR, Roesch P, Filut A, Hallgren E, Carnes M. The more things change, the more they stay the same: A study to evaluate compliance with inclusion and assessment of women and minorities in randomized controlled trials. Acad Med 2018; 93(4): 630-635. PMID: 29053489. PMCID: PMC5908758. doi: 10.1097/ACM.0000000000002027 27. Kolehmainen C, Carnes M. Who resembles a scientific leader-Jack or Jill? How implicit bias could influence research grant funding. Circulation 2018; 137(8): 769-770. PMID: 29459461 PMCID: PMC5822732. doi: 10.1161/CIRCULATIONAHA.117.031295 28. Pier EL*, Brauer M. Filut A*, Kaatz A, Raclaw J, Nathan MJ, Ford CE, Carnes M. Low agreement among reviewers evaluating the same NIH grant applications. Proc Nat Acad Sci USA 2018; 115(12) 2952- 2958. PMID: 29507248. PMCID: PMC5866547. doi: 10.1073/pnas.1714379115 29. Carnes M. The American College of Physicians is working hard to achieve gender equity and everyone will benefit. Ann Int Med 2018; 168(10): 741-743. PMID: 29710085 doi: 10.7326/M18-0837 30. Rogus-Pulia N, Humbert I, Kohlemainen C, Carnes M. Viewpoint: How gender stereotypes may limit female faculty advancement in communication sciences and disorders. Amer J Speech-Language Pathol 2018 Nov 21;27(4):1598-1611. PMID: 30383189 PMCID: PMC6436457 doi: 10.1044/2018_AJSLP-17-0140 31. Pankey T,* Alexander L*, Carnes M, Kaatz A, Kolehmainen C, Filut A*, Her-Xiong Y*, Stahr A*. Breaking the bias-habit: A workshop to help internal medicine residents reduce the impact of implicit bias. Understanding Interventions Journal 2018. 9(2) https://www.understandinginterventionsjournal.org/article/6355 32. Fine E, Sheridan J, Bell CF, Carnes M, Neimeko CJ, Romero M. Teaching academics about microaggressions: A workshop model adaptable to various audiences. Understanding Interventions Journal 2018. 9(2) www.understandinginterventionsjournal.org/article/6356 33. Pier EL*, Raclaw J, Carnes M, Ford CE, Kaatz A. Laughter and the chair: Social pressures influencing scoring during grant peer review meetings. J Gen Intern Med 2019. 34(4):513-4. PMID: 30604119 PMCID: PMC6445833 doi: 10.1007/s11606-018-4751-9 34. Carnes M, Fine E, Sheridan J. Promises and pitfalls of diversity statements: Proceed with caution. Acad Med 2019. 94(1): 20-24. PMID: 30067539 PMCID: PMC6309930 doi: 10.1097/ACM.0000000000002388 35. Rosser SV, Barnard S, Carnes M, Munir F. Athena SWAN and ADVANCE: Effectiveness and lessons learned. Lancet 2019. 9;393(10171):604-608. PMID: 30739697 doi:10.1016/S0140-6736(18)33213-6 36. Biernat M, Carnes M, Filut A, Kaatz A. Gender, race, and grant reviews: Translating and responding to research feedback. Pers Soc Psychol Bull 2020. 46(1): 140-154. PMID: 31088206 DOI: 10.1177/0146167219845921 37. Filut, A, Alvarez M, Carnes M. Discrimination toward physicians of color: A systematic review. Journal of the National Medical Association (accepted, October, 2019) | Yes | Vicki Leatherberry (vleatherberry@cwhr.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuceB7VyM9zlkEOa-o7Zo7Z1hYh9lCecTbas9Lnp8nW1fuo1W9tP8RWAaE33IHhKnr8 | ||||
| 14/12/2019 | Pediatrics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Neurodevelopmental outcomes of infants with potential Zika virus exposure: Approximately 10-15% of infants born to women with ZIKV infection during pregnancy develop birth defects ranging from hearing loss, decreased visual function and structural brain abnormalities, termed congenital Zika syndrome. The remaining 85-90% of infants are normal appearing at birth. Recent longitudinal cohort studies of these normal appearing infants (without congenital Zika syndrome diagnosed at birth) identified that 17% of these infants develop mild to moderate neurodevelopmental delays at 18 months of age. Within the UW Health system, we estimate that there are up to 300 women who had Zika virus infection during pregnancy and gave birth to infants that were not diagnosed with congenital Zika syndrome at birth. This estimate comes from a known group of 300 women who reported travel to Zika virus-endemic areas during pregnancy who did not experience symptoms of acute Zika virus infection (personal communication with Dr. Kathleen Antony, a maternal-fetal medicine specialist at UW Health). Whether these women had asymptomatic Zika virus infection was not defined because the CDC guidelines at the time of their travel recommended no Zika virus testing for asymptomatic people with potential travel exposures. Approximately 50% of people with Zika virus infection will be asymptomatic, so it is possible that these women had asymptomatic Zika virus infection. Asymptomatic Zika virus infection during pregnancy can also result in congenital Zika syndrome, potentially at similar rates as symptomatic Zika virus infections. Given that it is more likely to have an infant who is normal-appearing at birth than have a child affected by congenital Zika syndrome, if all these women had asymptomatic Zika virus infection, 17% (51/300) of these children may develop neurodevelopmental delays by the age of 18 months. The aim of our project is to define the neurodevelopmental outcomes of children born to women within the UW Health/Meriter system with a history of travel to Zika virus endemic regions during pregnancy. We will perform a retrospective chart review of the mother’s and child’s medical record to define maternal travel history and child neurodevelopmental parameters that were recorded during provider visits. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ ____________________________________________________________________________ Role - Retrospective chart reviewer and data analyst; IRB Status - Will be submitted in January 2020; Skills - Proficient in Epic, Microsoft Excel and Word | 0 | emohr2@wisc.edu | Emma | Mohr | MD, PhD | Emma Mohr, emohr2@wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.655.107 | Pediatric Infectious Diseases | Neurodevelopmental outcomes of infants with potential Zika virus exposure | Approximately 10-15% of infants born to women with ZIKV infection during pregnancy develop birth defects ranging from hearing loss, decreased visual function and structural brain abnormalities, termed congenital Zika syndrome. The remaining 85-90% of infants are normal appearing at birth. Recent longitudinal cohort studies of these normal appearing infants (without congenital Zika syndrome diagnosed at birth) identified that 17% of these infants develop mild to moderate neurodevelopmental delays at 18 months of age. Within the UW Health system, we estimate that there are up to 300 women who had Zika virus infection during pregnancy and gave birth to infants that were not diagnosed with congenital Zika syndrome at birth. This estimate comes from a known group of 300 women who reported travel to Zika virus-endemic areas during pregnancy who did not experience symptoms of acute Zika virus infection (personal communication with Dr. Kathleen Antony, a maternal-fetal medicine specialist at UW Health). Whether these women had asymptomatic Zika virus infection was not defined because the CDC guidelines at the time of their travel recommended no Zika virus testing for asymptomatic people with potential travel exposures. Approximately 50% of people with Zika virus infection will be asymptomatic, so it is possible that these women had asymptomatic Zika virus infection. Asymptomatic Zika virus infection during pregnancy can also result in congenital Zika syndrome, potentially at similar rates as symptomatic Zika virus infections. Given that it is more likely to have an infant who is normal-appearing at birth than have a child affected by congenital Zika syndrome, if all these women had asymptomatic Zika virus infection, 17% (51/300) of these children may develop neurodevelopmental delays by the age of 18 months. The aim of our project is to define the neurodevelopmental outcomes of children born to women within the UW Health/Meriter system with a history of travel to Zika virus endemic regions during pregnancy. We will perform a retrospective chart review of the mother’s and child’s medical record to define maternal travel history and child neurodevelopmental parameters that were recorded during provider visits. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ | Retrospective chart reviewer and data analyst | Relatively independent | Proficient in Epic, Microsoft Excel and Word | Will be submitted in January 2020 | Yes | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students | Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2. PMID: 29967348; PMCID: PMC6082723. Heffron AS, Mohr EL, Baker D, Haj AK, Buechler CR, Bailey A, Dudley DM, NewmanCM, Mohns MS, Koenig M, Breitbach ME, Rasheed M, Stewart LM, Eickhoff J, Pinapati RS, Beckman E, Li H, Patel J, Tan JC, O'Connor DH. Antibody responses to Zika virus proteins in pregnant and non-pregnant macaques. PLoS Negl Trop Dis. 2018 Nov 27;12(11):e0006903. doi: 0.1371/journal.pntd.0006903. eCollection 2018 Nov. PMID: 30481182. Mohr, EL. Modeling Zika virus-associated birth defects in nonhuman primates. J Pediatric Infec Dis Soc. 2018 Dec 26; 7(suppl_2): S60-S66. PMID: 30590626 Breitbach ME, Newman CM, Dudley DM, Stewart LM, Aliota MT, Koenig MR, Shepherd PM, Yamamoto K, Crooks CM, Young G, Semler MR, Weiler AM, Barry GL, Heimsath H, Mohr EL, Eichkoff J, Newton W, Peterson E, Schultz-Darken N, Permar SR, Dean H, Capuano S 3rd, Osorio JE, Friedrich TC, O'Connor DH. Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques. PLoS Pathog. 2019 Aug 1;15(8):e1007766. doi: 10.1371/journal.ppat.1007766. eCollection 2019 Aug. PubMed PMID: 31369649; PubMed Central PMCID: PMC6675051. Dudley DM, Aliota MT, Mohr EL, Newman CM, Golos TG, Friedrich TC, O'Connor DH. Using Macaques to Address Critical Questions in Zika Virus Research. Annu Rev Virol. 2019 Sep 29;6(1):481-500. doi: 10.1146/annurev-virology-092818-015732. Epub 2019 Jun 10. PubMed PMID: 31180813. | No | Brittney Quam | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudg14iG1ZuF3znVxdPksEkmQQiHb_-aO9StidB1uR9B54u_eEGrtuFy5DoKEvrA1Co | ||||||
| 15/12/2019 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Improving metabolic health through reduced consumption of specific dietary amino acids: Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ ____________________________________________________________________________ Role - The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation.; IRB Status - Approved; Skills - None | 0 | dlamming@medicine.wisc.edu | Dudley | Lamming | Ph.D. | Dudley Lamming, dlamming@medicine.wisc.edu -- Co-Mentor: Associate Professor Dawn Davis, MD, PhD dbd@medicine.wisc.edu | Assistant Professor | 608 | Endocrinology, Diabetes and Metabolism | Associate Professor Dawn Davis, MD, PhD | dbd@medicine.wisc.edu | Medicine | Endocrinology, Diabetes and Metabolism | Improving metabolic health through reduced consumption of specific dietary amino acids | Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ | The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation. | Medium - students will be co-mentored by Dr. Davis and will be supervised in the clinic by Dr. Rowan Karaman, a VA Advanced Fellow and UW Instructor, but will also work independently. Similarly, students will be trained in any mouse or cell culture work but will be expected to complete experiments independently. Students will analyze data and prepare presentations. | None | Approved | Yes | The Department of Medicine routinely provides this funding for Shapiro students. | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Fontana et al, 2016, Cell Reports, PMID: 27346343; Cummings et al, 2018, J Physiology, PMID: 29266268; additional manuscripts under review | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc3LysPzBsijg_sPEzKe6uw7sYL-fzHAHXHRXTgYS1Mxl_IRQo-RQocjrb9085fWOE | ||
| 15/12/2019 | Neurological Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Novel Immunotherapeutic Strategy for Malignant Brain Tumor: In Dey lab we are interested in developing novel immunotherapeutic strategies for Malignant brain tumor. Specifically we study Dendritic cell and T-cell interaction in the tumor microenvironment and T-cell dysfunction induced by tumor microenvironment, the role of epigenetic modifications in T-cell that leads to T-cell dysfunction, ways to optimize antigen presentation in tumor microenvironment and ways to reverse the changes using epigenetic modifying drugs. ____________________________________________________________________________ Role - Perform basic science bench work to help with the project under the supervision of current lab members.; IRB Status - n/a; Skills - basic cell culture | 1 | dey@neurosurgery.wisc.edu | Mahua | Dey | MD | Mahua Dey, dey@neurosurgery.wisc.edu -- Co-Mentor: | Assistant Professor of Neurological Surgery | Novel Immunotherapeutic Strategy for Malignant Brain Tumor | In Dey lab we are interested in developing novel immunotherapeutic strategies for Malignant brain tumor. Specifically we study Dendritic cell and T-cell interaction in the tumor microenvironment and T-cell dysfunction induced by tumor microenvironment, the role of epigenetic modifications in T-cell that leads to T-cell dysfunction, ways to optimize antigen presentation in tumor microenvironment and ways to reverse the changes using epigenetic modifying drugs. | Perform basic science bench work to help with the project under the supervision of current lab members. | moderate to high | basic cell culture | n/a | Yes | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | 1.Hasan T, Caragher, SP, Shireman JM, Park CH, Atashi F, Baisiwala S, Lee G, Guo D, Wang JY, Dey M, Lesniak MS, Horbinski CM, James CD, Ahmed AU, Interleukin-8/CXCR2 Signaling Regulates Therapy-Induced Plasticity and Enhances Tumorigenicity in Glioblastoma. Cell Death Dis. 10(4):292, 2019. 2.Huff W, Kwon J, Henriquez M, Fetcko K, Dey M. The Evolving Role of CD8+CD28- Immunosenescent T-cells in Cancer Immunology. Int. J Mol. Sci. 20(11), 2019. 3.Mitchell D, Dey M. Neoadjuvant anti-PD-1 Immunotherapy for Recurrent Glioblastoma. Transl Cancer Res 2019. (e-pub ahead of print) 4.Mitchell D, Chintala S, Fetcko K, Henriquez M, Tewari BN, Ahmed A, Bentley TR, Dey M. Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Theraputic Target. Front Oncol 2019. (e-pub ahead of print) 5.Mitchell D, Chintala S, Dey M. Plasmacytoid Dendritic Cell in Immunity and Cancer. J Neuroimmunol. 15;322:63-73, 2018. 6.Filley AC, Henriquez M, Dey M. CART Immunotherapy: Development Success and Translation to Malignant Glioma and Other Solid Tumors. Front Oncol 17;8:453, 2018. | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueTaiMIi3TZ1w0YQJNtePzhp5_-Idc5x3IK8f8MfUHm3wkuC5xWa2zqhWWAt3Wk-Ls | ||||||||
| 16/12/2019 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students, Shorter term projects | Effect of hydroxychloroquine on acute rejection post transplant in patients with ESRD due to Lupus Nephritis: Hydroxychloroquine (HCQ) leads to better patient survival and lowers lupus nephritis (LN) flares in patients with SLE. However, the effects of hydroxychloroquine have not been studied in patients with LN after kidney transplant. We have shown in our transplant patients with LN as cause of ESRD at UW, HCQ use leads to better patient and graft survival. Since HCQ is an immunomodulator, we hypothesize that HCQ use post- transplant leads to lower rejection rates. The goal of this project is to compare rates of acute rejection in transplant patients on plaquenil vs not on plaquenil with LN as cause of ESRD. ____________________________________________________________________________ Role - Chart review to look for acute rejection in transplant patients with Lupus Nephritis on plaquenil vs not on plaquenil Analyze the results Literature Review Writing manuscript; IRB Status - Approved; Skills - Look up labs in Healthlink, Doing pubmed search for literature review, Writing manuscript | 0 | tsingh@medicine.wisc.edu | Tripti | Singh | MD | Tripti Singh, tsingh@medicine.wisc.edu -- Co-Mentor: | Dr. | 4.128.770.852 | Nephrology | Effect of hydroxychloroquine on acute rejection post transplant in patients with ESRD due to Lupus Nephritis | Hydroxychloroquine (HCQ) leads to better patient survival and lowers lupus nephritis (LN) flares in patients with SLE. However, the effects of hydroxychloroquine have not been studied in patients with LN after kidney transplant. We have shown in our transplant patients with LN as cause of ESRD at UW, HCQ use leads to better patient and graft survival. Since HCQ is an immunomodulator, we hypothesize that HCQ use post- transplant leads to lower rejection rates. The goal of this project is to compare rates of acute rejection in transplant patients on plaquenil vs not on plaquenil with LN as cause of ESRD. | Chart review to look for acute rejection in transplant patients with Lupus Nephritis on plaquenil vs not on plaquenil Analyze the results Literature Review Writing manuscript | Low | Look up labs in Healthlink, Doing pubmed search for literature review, Writing manuscript | Approved | No | Yes | Yes | Not currently available to mentor other students | Submitted abstract to ATC - Hydroxychloroquine is associated with better patient and graft survival in kidney transplant patients with lupus nephritis as cause of ESRD | Yes | Audrey Nelson | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf8hMbtSfjb820WR_hnBTKgpIQiYjvzTPaj5NukfdTpfxQciR4WvULMhOU5w5GZtT4 | ||||||
| 12/01/2020 | Medicine | Shorter term projects, Research Electives for credit | Assessing Care of Adolescents and Young Adults with Cancer at the University of Wisconsin: This project is designed to help us better understand the adolescent and young adult (AYA) population being cared for at the University of Wisconsin, as well as areas for care improvement. AYA patients (ages 15-39) with cancer are a unique population, with their own diagnoses, complications, morbidities, and psychosocial concerns distinct from their peers and cancer patients in other age groups. These patients face challenges related to work, school, health insurance, relationships, sexuality and fertility, as well as emotional distress and depression. These unique needs necessitate clear documentation of items such as discussion of fertility preservation, as well as involvement with multiple other disciplines including social work, case management, psychology, child life, pain and palliative care, occupational and physical therapy, nutrition, and genetics. Despite this recognition and multiple guidelines supporting these needs, there is limited data regarding the care of AYA patients prior to the implementation of AYA programs. This project would identify AYA patients who have received cancer care at the University of Wisconsin and allow for baseline assessment of resource and specialist utilization, as well as documentation of essential care components (e.g. fertility preservation discussions). We would also plan to survey these AYA patients regarding their care experiences. While we would expect publication based on compilation of this baseline data, we will ultimately plan to compare this baseline data with post-intervention data following implementation of an AYA program at the University of Wisconsin. Areas for care improvement identified by this project would be considered in the design of the planned AYA program. ____________________________________________________________________________ Role - The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript. ; IRB Status - This project is IRB exempt. ; Skills - Required skills include: literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing. | 0 | amparkes@medicine.wisc.edu | Amanda | Parkes | MD | Amanda Parkes, amparkes@medicine.wisc.edu -- Co-Mentor: Amye Tevaarwerk tevaarwerk@wisc.edu | Assistant Professor | 608 | Hematology/Oncology | Amye Tevaarwerk | tevaarwerk@wisc.edu | Medicine | Hematology/Oncology | Assessing Care of Adolescents and Young Adults with Cancer at the University of Wisconsin | This project is designed to help us better understand the adolescent and young adult (AYA) population being cared for at the University of Wisconsin, as well as areas for care improvement. AYA patients (ages 15-39) with cancer are a unique population, with their own diagnoses, complications, morbidities, and psychosocial concerns distinct from their peers and cancer patients in other age groups. These patients face challenges related to work, school, health insurance, relationships, sexuality and fertility, as well as emotional distress and depression. These unique needs necessitate clear documentation of items such as discussion of fertility preservation, as well as involvement with multiple other disciplines including social work, case management, psychology, child life, pain and palliative care, occupational and physical therapy, nutrition, and genetics. Despite this recognition and multiple guidelines supporting these needs, there is limited data regarding the care of AYA patients prior to the implementation of AYA programs. This project would identify AYA patients who have received cancer care at the University of Wisconsin and allow for baseline assessment of resource and specialist utilization, as well as documentation of essential care components (e.g. fertility preservation discussions). We would also plan to survey these AYA patients regarding their care experiences. While we would expect publication based on compilation of this baseline data, we will ultimately plan to compare this baseline data with post-intervention data following implementation of an AYA program at the University of Wisconsin. Areas for care improvement identified by this project would be considered in the design of the planned AYA program. | The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript. | High | Required skills include: literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing. | This project is IRB exempt. | No | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students | This project is part of a larger research effort on survivorship and multiple publications by my co-mentor on this topic can be found on Pubmed or by following this link on NCBI: https://www.ncbi.nlm.nih.gov/myncbi/amye.tevaarwerk.1/bibliography/public/ | Yes | Julene Gaspard | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucwwkGZ2H7xmjyI2UnlUhW2vBq7wrdzIgYuTUlYcFliOpubeiPe9Ge5GUk4hZ4tK8g | ||
| 17/12/2019 | Oncology | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Develop Epigenetic Therapy for Wilms Tumors : https://mcardle.wisc.edu/who-we-are/mcardle-faculty/wei-xu-phd ____________________________________________________________________________ Role - participate in research; IRB Status - N/A; Skills - basic molecular biology | 1 | wxu@oncology.wisc.edu | Wei | Xu | PhD | Wei Xu, wxu@oncology.wisc.edu -- Co-Mentor: Hau Le leh@surgery.wisc.edu | Professor | 6.082.655.540 | Hau Le | leh@surgery.wisc.edu | Surgery | Medicine | Develop Epigenetic Therapy for Wilms Tumors | https://mcardle.wisc.edu/who-we-are/mcardle-faculty/wei-xu-phd | participate in research | independent | basic molecular biology | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students | none | Yes | Chris Carollo-Zeuner | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud7ZolMxlhym_TrteW2NYTwtosy6n_CUSSFD5Bok2FDckTC1LzvqTNYmOFGBoClB_E | |||
| 17/12/2019 | Radiology | Shorter term projects | Correlation of lower urinary tract symptom scores (LUTS) with quantitative MRI of the bladder : Student(s) will work with a collaborative cross-disciplinary team (urology, radiology, biomedical engineering, medical physics, statisticians, graduate students). MR images of the bladder (and prostate) will be manually contoured (Mimics Innovation); segmentation and 3D anatomic renderings will be used to correlate changes in the bladder muscle in patients without and with lower urinary tract symptoms (bladder obstruction and underactive bladder). ____________________________________________________________________________ Role - Mentored Data collection, Data analysis, Abstract and Manuscript creation, Presentation(s); IRB Status - HIPPA compliant, IRB approved; Skills - No specific skill required. | 0 | sawells@wisc.edu | Shane | Wells | MD | Shane Wells, sawells@wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Abdominal Imaging and Intervention | Correlation of lower urinary tract symptom scores (LUTS) with quantitative MRI of the bladder | Student(s) will work with a collaborative cross-disciplinary team (urology, radiology, biomedical engineering, medical physics, statisticians, graduate students). MR images of the bladder (and prostate) will be manually contoured (Mimics Innovation); segmentation and 3D anatomic renderings will be used to correlate changes in the bladder muscle in patients without and with lower urinary tract symptoms (bladder obstruction and underactive bladder). | Mentored Data collection, Data analysis, Abstract and Manuscript creation, Presentation(s) | Self motivated. | No specific skill required. | HIPPA compliant, IRB approved | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | Anzia LE et al. Pelvic MRI with segmentation and 3D anatomical renderings allow quantitative analysis of the lower urinary tract. (submitted) | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufexRVTKr7e2_mfjLQcfgf54dcAgiSYPJFX6HqeUKpOyLXtS1Gzx3eZoUYXR1XJnh4 | ||||||
| 17/12/2019 | Radiology | Shorter term projects | Prostate transition zone apparent diffusion coefficient (ADC) on MR imaging correlates with lower urinary tract symptoms (LUTS) : Students will work with a collaborative cross-discipline team (urology, radiology, biomedical engineering, medical physics, statisticians, graduate students). Students will correlate prostate size and volume (Mimics Innovation Software) and apparent diffusion coefficient (ADC) values with bladder wall thickness and detrussor muscle volume and the relationship with lower urinary tract symptoms. ____________________________________________________________________________ Role - Mentored Data collection, Data Analysis, Abstract and Manuscript preparation, Presentation(s); IRB Status - HIPPA compliant, IRB approved; Skills - No specific skills required. Will train students on MR imaging and post-processing software. | 0 | sawells@wisc.edu | Shane | Wells | MD | Shane Wells, sawells@wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Abdominal Imaging and Intervention | Prostate transition zone apparent diffusion coefficient (ADC) on MR imaging correlates with lower urinary tract symptoms (LUTS) | Students will work with a collaborative cross-discipline team (urology, radiology, biomedical engineering, medical physics, statisticians, graduate students). Students will correlate prostate size and volume (Mimics Innovation Software) and apparent diffusion coefficient (ADC) values with bladder wall thickness and detrussor muscle volume and the relationship with lower urinary tract symptoms. | Mentored Data collection, Data Analysis, Abstract and Manuscript preparation, Presentation(s) | Self-motivated. | No specific skills required. Will train students on MR imaging and post-processing software. | HIPPA compliant, IRB approved | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | Zhang Y et al. Stimulated-Echo diffusion weighted imaging with moderate b-values for the detection of prostate cancer. (submitted) Zhang Y et al. Stimulated Echo-based Mapping (STEM) of T1, T2 and Apparent Diffusoin Coefficient: Validation and Protocol Optimization. Magn Reson Med 2019;81(1):167-181. Zhang Y et al. Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging. Magn Reson Imaging 2018;9(51): 173-181. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucQUKLIKNyDR-B6duueYFkvh8tX2iXGjj3p0kXDbm9rh5gqnouZJB8wrc6-xYTA2lk | ||||||
| 17/12/2019 | Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Cancer Fear in Patients with Thyroid Nodules: Cancer fear is defined as any fear, anxiety, or worry related to cancer. We have shown that patients with thyroid cancer have cancer fear and emotional responses similar to patients with more aggressive malignancies. However, little is know about when this fear begins. We hypothesize that patients undergoing cervical ultrasound and biopsy of their thyroid nodule(s) have increased cancer fear. This project will involve primary data collection from patients undergoing thyroid ultrasound and biopsy using a validated cancer fear and anxiety scales. The student will learn to perform the subsequent analysis, data presentation, and manuscript preparation. Dr. Pitt has also multiple additional ongoing IRB-approved studies that students could be involved with depending on their interests. These studies use qualitative, quantitative, survey, and stated preferences methods to examine overtreatment of low-risk thyroid cancer. Patients and their doctors often prefer the most aggressive treatment even when it has higher risks and goes against published guidelines. The research principles utilized in this work can be applied throughout all areas of medicine. ____________________________________________________________________________ Role - Data collection and analysis, abstract and manuscript writing; IRB Status - Pending/Approved depending on student's project; Skills - Knowledge of basic statistics and RedCaps would be helpful, but not required | 0 | pitt@surgery.wisc.edu | Susan | Pitt | MD, MPHS | Susan Pitt, pitt@surgery.wisc.edu -- Co-Mentor: | Assistant Professor of Surgery | 608 | Division of Endocrine Surgery | Cancer Fear in Patients with Thyroid Nodules | Cancer fear is defined as any fear, anxiety, or worry related to cancer. We have shown that patients with thyroid cancer have cancer fear and emotional responses similar to patients with more aggressive malignancies. However, little is know about when this fear begins. We hypothesize that patients undergoing cervical ultrasound and biopsy of their thyroid nodule(s) have increased cancer fear. This project will involve primary data collection from patients undergoing thyroid ultrasound and biopsy using a validated cancer fear and anxiety scales. The student will learn to perform the subsequent analysis, data presentation, and manuscript preparation. Dr. Pitt has also multiple additional ongoing IRB-approved studies that students could be involved with depending on their interests. These studies use qualitative, quantitative, survey, and stated preferences methods to examine overtreatment of low-risk thyroid cancer. Patients and their doctors often prefer the most aggressive treatment even when it has higher risks and goes against published guidelines. The research principles utilized in this work can be applied throughout all areas of medicine. | Data collection and analysis, abstract and manuscript writing | High degree of independence | Knowledge of basic statistics and RedCaps would be helpful, but not required | Pending/Approved depending on student's project | Yes | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, UW undergraduates interested in research, Not currently available to mentor other students | 1. Jensen CB, Saucke MC, Jennings JL, Khokhar HK, Voils CI, Pitt SC. Overtreatment: A Qualitative Analysis of Surgeons, Endocrinologists, and Patients with Thyroid Cancer. Thyroid (submitted - under review) 2. Pitt SC, Wendt E, Saucke MC, Voils, CI, Orne J, Macdonald C, Connor NP, Sippel RS. A Qualitative Analysis of the Preoperative Needs of Patients with Papillary Thyroid Cancer. J Surg Research 2019;244:324-331. 3. Dedhia PH, Saucke MC, McDow AD, Long KL, Pitt SC. Overtreatment of Patients with Low-Risk Thyroid Cancer: Results of a Large National Survey of Physicians. (in preparation) 4. McDow AD, Brito JP, Saucke MC, Zaborek N, Jennings JL, Davies L, Voils, CI, Roman BR, Pitt SC. Factors Associated with Providers’ Treatment Recommendations for Low-Risk Papillary Thyroid Cancer. Ann Surg (submitted) 5. Price AK, Randle RW, Schneider DF, Sippel RS, Pitt SC. Papillary Thyroid Microcarcinoma: Decision-Making, Extent of Surgery, and Outcomes. J Surg Research 2017 Oct;218:237-245. | Yes | Megan Saucke, saucke@surgery.wisc.edu, 608-265-2458 | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufb4v49iPIP_8tKuZO8hiidJmZU1VsG-_2R3r1Pd4dG8TtAG3V5FMq5mZANwjt44rs | ||||||
| 17/12/2019 | Urology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | AUTOMATED IMAGE ANALYSIS OF HISTOLOGICALLY BENIGN PROSTATE BIOPSIES PREDICTS CANCER PRESENCE’ : The Jarrard research programs utilize translational and clinical research to examine aspects underlying prostate cancer development and progression. Using our established database of over 2000 patients we have published with previous Shapiro students on identifying features that help better predict and guide the management of patients with this disease. The current project is entitled ‘AUTOMATED IMAGE ANALYSIS OF HISTOLOGICALLY BENIGN PROSTATE BIOPSIES PREDICTS CANCER PRESENCE’ and utilizes computer based digital imaging to examine features on non-tumor prostate biopsies that predict the presence of cancer. This builds on several previous observations and seeks to improve the diagnosis of prostate cancer. ____________________________________________________________________________ Role - Role – data collection and analysis, abstract and manuscript writing; IRB Status - approved; Skills - basic statistical skills and some computer programming encouraged | 0 | jarrard@urology.wisc.edu | david | jarrard | MD | david jarrard, jarrard@urology.wisc.edu -- Co-Mentor: | Professor, Associate Director Carbone Cancer Center | 265 | AUTOMATED IMAGE ANALYSIS OF HISTOLOGICALLY BENIGN PROSTATE BIOPSIES PREDICTS CANCER PRESENCE’ | The Jarrard research programs utilize translational and clinical research to examine aspects underlying prostate cancer development and progression. Using our established database of over 2000 patients we have published with previous Shapiro students on identifying features that help better predict and guide the management of patients with this disease. The current project is entitled ‘AUTOMATED IMAGE ANALYSIS OF HISTOLOGICALLY BENIGN PROSTATE BIOPSIES PREDICTS CANCER PRESENCE’ and utilizes computer based digital imaging to examine features on non-tumor prostate biopsies that predict the presence of cancer. This builds on several previous observations and seeks to improve the diagnosis of prostate cancer. | Role – data collection and analysis, abstract and manuscript writing | Modest | basic statistical skills and some computer programming encouraged | approved | No | Yes | Yes | Not currently available to mentor other students | Yang B, Etheridge T, McCormick J, Schultz A, Khemees TA, Damaschke N, Woo K, Sonn GA, Klein EA, Fumo M, Huang W, and Jarrard D, Validation of an epigenetic field of susceptibility to detect significant prostate cancer from non-tumor biopsies. Clin Epigenetics (in press) Wang JH, Sierra P, Richards KA, Abel EJ, Allen GO, Downs TM, Jarrard DF. Impact of bilateral biopsy-detected prostate cancer on an active surveillance population. BMC Urol. 2019 Apr 23;19(1):26 | Yes | steve hall | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueaN5INFbpvFo3LRLSBE0M-Lm9Z_HQkMoPbOSyG8k0JO2Qt10cTywgslEJ73x_XbFo | |||||||
| 18/12/2019 | Radiology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | CRISPR Editing of the Progesterone Receptor Gene in Breast Cancer Cells: My lab has recently identified several mutations in the progesterone receptor (PR) gene using metastatic tumor samples from patients with breast cancer. Little is known about the functional significance of these tumor mutations. We have discovered one mutation that causes reduced function of PR protein and may be associated with reduced patient survival. This Shapiro Summer Research Project will be focused on creating genetically modified breast cancer cell lines using CRISPR technology to express the tumor specific PR gene mutations present in patient samples for further investigation. The overall goal of creating these cells will be to study the functional impact of the mutations on PR function as a ligand-activated transcription factor, on tumor cell growth, on sensitivity to endocrine therapy drugs, and on noninvasive imaging using a progestin-based radiopharmaceutical. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ ____________________________________________________________________________ Role - Under the supervision of the project mentor, the student will design and perform genomic editing experiments of the human progesterone receptor gene using breast cancer cell lines grown in culture. Molecular techniques that the student will learn include assays such as DNA sequencing, transfection, electroporation, PCR, agarose gel electrophoresis, and cell culture.; IRB Status - N/A; Skills - Prior degree or undergraduate coursework in biology, microbiology, genetics, chemistry or related field is preferred. Completion of biosafety training is required prior to the start of the project. | 0 | afowler@uwhealth.org | Amy | Fowler | MD, PhD | Amy Fowler, afowler@uwhealth.org -- Co-Mentor: | Assistant Professor | 608 | Breast Imaging | Medical Physics | CRISPR Editing of the Progesterone Receptor Gene in Breast Cancer Cells | My lab has recently identified several mutations in the progesterone receptor (PR) gene using metastatic tumor samples from patients with breast cancer. Little is known about the functional significance of these tumor mutations. We have discovered one mutation that causes reduced function of PR protein and may be associated with reduced patient survival. This Shapiro Summer Research Project will be focused on creating genetically modified breast cancer cell lines using CRISPR technology to express the tumor specific PR gene mutations present in patient samples for further investigation. The overall goal of creating these cells will be to study the functional impact of the mutations on PR function as a ligand-activated transcription factor, on tumor cell growth, on sensitivity to endocrine therapy drugs, and on noninvasive imaging using a progestin-based radiopharmaceutical. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ | Under the supervision of the project mentor, the student will design and perform genomic editing experiments of the human progesterone receptor gene using breast cancer cell lines grown in culture. Molecular techniques that the student will learn include assays such as DNA sequencing, transfection, electroporation, PCR, agarose gel electrophoresis, and cell culture. | After initial training, a moderate degree of independence is required for completion of this project. | Prior degree or undergraduate coursework in biology, microbiology, genetics, chemistry or related field is preferred. Completion of biosafety training is required prior to the start of the project. | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | “Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer.” Amy M. Fowler, Kelley Salem, Michael DeGrave, Irene M. Ong, Shane Rassman, Ginny L. Powers, Manoj Kumar, Ciara J. Michel, Aparna M. Mahajan. Revised manuscript submitted to Hormones and Cancer Salem K, Kumar M, Yan Y, Jeffery JJ, Kloepping KC, Michel CJ, Powers GL, Mahajan AM, Fowler AM. Sensitivity and isoform specificity of 18F-fluorofuranylnorprogesterone for measuring progesterone receptor protein response to estradiol challenge in breast cancer. J Nucl Med 2019;60:220-226. PMID: 30030339. Kumar M, Salem K, Michel CJ, Jeffery JJ, Yan Y, Fowler AM. 18F-Fluoroestradiol positron emission tomography imaging of activating estrogen receptor alpha mutations in breast cancer. J Nucl Med 2019;60:1247-1252. PMID: 30850489. Kumar M, Salem K, Tevaarwerk AJ, Strigel RM, Fowler AM. Recent advances in imaging steroid hormone receptors in breast cancer. J Nucl Med 2019 Nov 15. pii: jnumed.119.228858. doi: 10.2967/jnumed.119.228858. [Epub ahead of print]. | Yes | Kelley Salem, PhD | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudDcPuSRNUHgdxikFB6RiBxqnTJuW92wf3qdy8kqcLf8dIajR2wJzTb9v56GLxGhZA | |||||
| 18/12/2019 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Controlling Hypertension in the VA Nephrology Clinic: Poor control of blood pressure has been linked to poor outcomes in patients. We have started to show that particular interventions such as telehealth, telepharmacy and other interventions can improve control of the blood pressures. In this project we would compare control of blood pressure from the data noted in the VA nephrology clinic with the data gathered in the pharmacist intervention with the hypothesis that this intervention should be more widely implemented. ____________________________________________________________________________ Role - Data collection, analysis and primary author; IRB Status - NA; Skills - Data entry and some scientific writing | 0 | lmaursetter@medicine.wisc.edu | Laura | Maursetter | DO | Laura Maursetter, lmaursetter@medicine.wisc.edu -- Co-Mentor: John Dopp john.dopp@wisc.edu | Associate Professor | 6.082.399.616 | Nephrology | John Dopp | john.dopp@wisc.edu | Other | Pharmacy | Controlling Hypertension in the VA Nephrology Clinic | Poor control of blood pressure has been linked to poor outcomes in patients. We have started to show that particular interventions such as telehealth, telepharmacy and other interventions can improve control of the blood pressures. In this project we would compare control of blood pressure from the data noted in the VA nephrology clinic with the data gathered in the pharmacist intervention with the hypothesis that this intervention should be more widely implemented. | Data collection, analysis and primary author | Self Starter | Data entry and some scientific writing | NA | No | Would ask the department of medicine | Yes | Not currently available to mentor other students | IN preparation | Yes | Betty Weiss | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudWPqqWuFyNiagoV1YvmQIMabeI8zTUSgyZGn8F8a7guGWlKqC90OhY0cV1nQNDyJs | ||
| 18/12/2019 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Clinical factors influencing neutrophil function in patients with invasive candidiasis: Patients with indwelling medical devices, such as venous catheters, are at risk for invasive disease caused by Candida, one of the most common human fungal pathogens. In these patients, Candida sticks to the device surface and proliferates as a biofilm of resilient cells encased in an organism-derived extracellular matrix. As the host immune system and conventional antifungals are not capable of eradicating Candida biofilms, these infections can be devastating. When examining neutrophils from healthy patients, we found poor antifungal activity against Candida during biofilm growth. We are now delineating the neutrophil response to biofilm for patients with invasive candidiasis. The current project involves collecting and analyzing clinical data from the charts of these patients. cells.https://www.medicine.wisc.edu/infectious-disease/nett-research-lab ____________________________________________________________________________ Role - A Shapiro student would collect data from charts and assist with data analysis. The student could also participate in neutrophil-Candida studies if interested. ; IRB Status - Approved; Skills - No prior research experience is required. | 0 | jenett@medicine.wisc.edu | Jeniel | Nett | MD PhD | Jeniel Nett, jenett@medicine.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Infectious Diseases | Medical Microbiology & Immunology | Clinical factors influencing neutrophil function in patients with invasive candidiasis | Patients with indwelling medical devices, such as venous catheters, are at risk for invasive disease caused by Candida, one of the most common human fungal pathogens. In these patients, Candida sticks to the device surface and proliferates as a biofilm of resilient cells encased in an organism-derived extracellular matrix. As the host immune system and conventional antifungals are not capable of eradicating Candida biofilms, these infections can be devastating. When examining neutrophils from healthy patients, we found poor antifungal activity against Candida during biofilm growth. We are now delineating the neutrophil response to biofilm for patients with invasive candidiasis. The current project involves collecting and analyzing clinical data from the charts of these patients. cells.https://www.medicine.wisc.edu/infectious-disease/nett-research-lab | A Shapiro student would collect data from charts and assist with data analysis. The student could also participate in neutrophil-Candida studies if interested. | Training will be provided and a student can work independently as skills are gained. | No prior research experience is required. | Approved | Yes | Yes | Yes | PhD students | Most relevant: Johnson CJ, J Cabezas-Olcoz, JF Kernien, SX Wang, DJ Beebe, A Huttenlocher, H Ansari, JE Nett. 2016. The Extracellular matrix of Candida albicans biofilms impairs formation of neutrophil extracellular traps. PLoS Path. PMID 27622514 Other laboratory manuscripts: https://scholar.google.com/citations?user=tqo8wwcAAAAJ&hl=en | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufP2aBcLPbegzvesebzpvEVqPWedMdnxip6wVWVohQKsfmlWc7H-NLCytxkyBF2xw0 | |||||
| 18/12/2019 | Medicine | Research Electives for credit | Developing Sjogren's Syndrome Retrospective Registry to Study Osteoporosis: Sjogren's syndrome (SS) is an autoimmune disease with cardinal symptoms of dry eyes and mouth but is a systemic disease that can affect multiple organ systems. SS leads to increased patient morbidity and healthcare costs. Unfortunately, the pathophysiology of SS is poorly understood, leading to significant gaps in diagnosis and treatment of this common disease. No FDA approved treatment for SS exists. Instead, treatment focuses on specific organ involvement, using globally immunosuppressive medications. By understanding the pathogenesis of SS, we can create targeted and better tolerated therapies. Toward this end, we aim to establish the first UW retrospective SS repository. The repository will be composed of clinical data on primary and secondary SS and include a control group composed of patients with sicca who do not have a systemic autoimmune disease. We seek a scholar to perform chart review and data abstraction, using a standardized tool. The scholar will become proficient with review of medical records in the electronic database, Epic, and will abstract data to enter into the repository. Once data abstraction is complete, the first project will involve evaluating the association of SS with osteoporosis based on bone mineral density test results. SS is a female predominant disease (20:1 female to male) and we have established that estrogen appears to reduce the development of SS. Thus we would like to evaluate how osteoporosis, a disease strongly associated with estrogen exposure, is associated with SS. ____________________________________________________________________________ Role - Data abstraction from medical records to complete the retrospective Sjogren's registry. ; IRB Status - complete; Skills - none | 0 | ssmccoy@medicine.wisc.edu | Sara | McCoy | MD | Sara McCoy, ssmccoy@medicine.wisc.edu -- Co-Mentor: Karen Hansen keh@medicine.wisc.edu> | Associate Professor | 6.082.620.908 | Rheumatology | Karen Hansen | keh@medicine.wisc.edu> | Medicine | Rheumatology | Developing Sjogren's Syndrome Retrospective Registry to Study Osteoporosis | Sjogren's syndrome (SS) is an autoimmune disease with cardinal symptoms of dry eyes and mouth but is a systemic disease that can affect multiple organ systems. SS leads to increased patient morbidity and healthcare costs. Unfortunately, the pathophysiology of SS is poorly understood, leading to significant gaps in diagnosis and treatment of this common disease. No FDA approved treatment for SS exists. Instead, treatment focuses on specific organ involvement, using globally immunosuppressive medications. By understanding the pathogenesis of SS, we can create targeted and better tolerated therapies. Toward this end, we aim to establish the first UW retrospective SS repository. The repository will be composed of clinical data on primary and secondary SS and include a control group composed of patients with sicca who do not have a systemic autoimmune disease. We seek a scholar to perform chart review and data abstraction, using a standardized tool. The scholar will become proficient with review of medical records in the electronic database, Epic, and will abstract data to enter into the repository. Once data abstraction is complete, the first project will involve evaluating the association of SS with osteoporosis based on bone mineral density test results. SS is a female predominant disease (20:1 female to male) and we have established that estrogen appears to reduce the development of SS. Thus we would like to evaluate how osteoporosis, a disease strongly associated with estrogen exposure, is associated with SS. | Data abstraction from medical records to complete the retrospective Sjogren's registry. | Initial teaching on abstraction tool (Redcap) and data abstraction is provided. | none | complete | KL2 scholar | Plan to apply to DOM research committee for matching Shapiro program funds | Yes | UW undergraduates interested in research | McCoy SS, Sampene E, Baer AN. Sjögren’s Syndrome Is Associated With Reduced Sex Hormone Exposure: A Cross-Sectional Study. Arthritis Care Res (Hoboken). 2019 Jun 24. PMID 31233285 | Yes | Jason Weitzman jweitzman@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud43piQbJPXs3nnB6uhEVQv5k98NctXFg3RPmAdo9G8KI6TOTDNExePRqCa7ZUYn3o | ||
| 18/12/2019 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Optimizing neutrophil activity against Candida auris: Emerging fungal pathogen Candida auris is spreading in healthcare settings worldwide. Mortality is high for patients with invasive disease and treatment options are often limited. Neutrophils are critical for control of many invasive fungal infections, including candidiasis. However, we found that neutrophils exhibit poor activity against C. auris. While the majority fail to phagocytose C. auris, a small subset rapidly engulf numerous C. auris. The goal of the current project is to characterize the cell markers on this effective subset of neutrophils. Subsequent studies involve using this information to pharmacologically treat neutrophils, enhancing for this subset. ____________________________________________________________________________ Role - A Shapiro student would perform Candida-neutrophil experiments, analyzing the expression of neutrophil surface markers.; IRB Status - Approved; Skills - No prior research experience required. | 0 | jenett@medicine.wisc.edu | Jeniel | Nett | MD PhD | Jeniel Nett, jenett@medicine.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Infectious Diseases | Medical Microbiology & Immunology | Optimizing neutrophil activity against Candida auris | Emerging fungal pathogen Candida auris is spreading in healthcare settings worldwide. Mortality is high for patients with invasive disease and treatment options are often limited. Neutrophils are critical for control of many invasive fungal infections, including candidiasis. However, we found that neutrophils exhibit poor activity against C. auris. While the majority fail to phagocytose C. auris, a small subset rapidly engulf numerous C. auris. The goal of the current project is to characterize the cell markers on this effective subset of neutrophils. Subsequent studies involve using this information to pharmacologically treat neutrophils, enhancing for this subset. | A Shapiro student would perform Candida-neutrophil experiments, analyzing the expression of neutrophil surface markers. | Training is provided and students become independent with experience. | No prior research experience required. | Approved | Yes | Yes | Yes | PhD students | Most relevant: Johnson CJ, Davis JM, Huttenlocher A, Kernien JF, JE Nett. 2018. Emerging fungal pathogen Candida auris evades neutrophil attack. MBio 9(4):1-9. PMID: 30131360 Other lab manuscripts: https://scholar.google.com/citations?user=tqo8wwcAAAAJ&hl=en | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueiYWFNYjDlIrRPjcQJoNNYMdewvTNJxRDA7e_kAxmGaC43fuHEKBGjvW_DWt5Whwo | |||||
| 19/12/2019 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Oral Microbiome & Pneumonia : The Oral Microbiome & Pneumonia project is a prospective, pre-post intervention study of probiotics in older adults with dysphagia examining the feasibility of a probiotic regimen and characterization of the oral microbiota changes with this intervention. Our ultimate goal is determining the efficacy of this intervention for pneumonia prevention in at risk older adults with dysphagia. ____________________________________________________________________________ Role - Depending on the specific interests and timeframe of applicants, this project has several opportunities for involvement from performing clinical research, collaborating on the translational work to characterize the oral microbiome, performing data analysis and writing manuscripts. ; IRB Status - Approved; Skills - High level communication skills including comfort interacting with patients and ability to collaborate effectively with other researchers. Experience or willingness to learn data analysis techniques and manuscript writing. | 0 | npulia@wisc.edu | Nicole | Pulia | PhD, CCC-SLP | Nicole Pulia, npulia@wisc.edu -- Co-Mentor: | Assistant Professor | 1 | Geriatrics & Gerontology | Surgery | Otolaryngology - Head & Neck | Oral Microbiome & Pneumonia | The Oral Microbiome & Pneumonia project is a prospective, pre-post intervention study of probiotics in older adults with dysphagia examining the feasibility of a probiotic regimen and characterization of the oral microbiota changes with this intervention. Our ultimate goal is determining the efficacy of this intervention for pneumonia prevention in at risk older adults with dysphagia. | Depending on the specific interests and timeframe of applicants, this project has several opportunities for involvement from performing clinical research, collaborating on the translational work to characterize the oral microbiome, performing data analysis and writing manuscripts. | Moderate level of independence, will be supported by Lab staff | High level communication skills including comfort interacting with patients and ability to collaborate effectively with other researchers. Experience or willingness to learn data analysis techniques and manuscript writing. | Approved | Yes | Yes | Yes | PhD students | Rogus-Pulia, N.M., et al., Effects of Change in Tongue Pressure and Salivary Flow Rate on Swallow Efficiency Following Chemoradiation Treatment for Head and Neck Cancer.Dysphagia, 2016. 31(5): p. 687-96. Rogus-Pulia, N., et al., Effects of Device-Facilitated Isometric Progressive Resistance Oropharyngeal Therapy on Swallowing and Health-Related Outcomes in Older Adults with Dysphagia.J Am Geriatr Soc, 2016. 64(2): p. 417-24. Rogus-Pulia, N., et al., Salivary Quantity and Viscosity: Effects on Perceived Swallow Effort and Oropharyngeal Residue in Patients with Dysphagia, in Dysphagia Research Society. 2016: Tuscon, Arizona. p. 786-845. Rogus-Pulia, N.M., et al., A Pilot Study of Perceived Mouth Dryness, Perceived Swallowing Effort, and Saliva Substitute Effects in Healthy Adults Across the Age Range.Dysphagia, 2017. Advance online publication. doi: 10.1007/s00455-017-9846-7. Rogus-Pulia, N.M., et al., Changes in swallowing physiology and patient perception of swallowing function following chemoradiation for head and neck cancer.Dysphagia, 2014. 29(2): p. 223-33. Patel, D.A., et al., Economic and survival burden of dysphagia among inpatients in the United States.Dis Esophagus, 2017. Advance online publication. doi: 10.1093/dote/dox131. Scannapieco, F.A. and K. Shay, Oral health disparities in older adults: oral bacteria, inflammation, and aspiration pneumonia.Dent Clin North Am, 2014. 58(4): p. 771-82 Cabre, M., et al., Oropharyngeal dysphagia is a risk factor for readmission for pneumonia in the very elderly persons: observational prospective study.J Gerontol A Biol Sci Med Sci, 2014. 69(3): p. 330-7. Kilian, M., et al., The oral microbiome -an update for oral healthcare professionals.Br Dent J, 2016. 221(10): p. 657-666. Marsh, P.D., D.A. Head, and D.A. Devine, Ecological approaches to oral biofilms: control without killing.Caries Res, 2015. 49 Suppl 1: p. 46-54. Ortega, O., et al., High prevalence of colonization of oral cavity by respiratory pathogens in frail older patients with oropharyngeal dysphagia.Neurogastroenterol Motil, 2015. 27(12): p. 1804-16. Ortega, O., et al., Oral health in older patients with oropharyngeal dysphagia.Age and ageing, 2014. 43(1): p. 132-137. Robbins, J., et al., Age-Related Differences in Pressures Generated During Isometric Presses and Swallows by Healthy Adults.Dysphagia, 2016. 31(1): p. 90-6. Carrion, S., et al., Oropharyngeal dysphagia is a prevalent risk factor for malnutrition in a cohort of older patients admitted with an acute disease to a general hospital.Clin Nutr, 2015. 34(3): p. 436-42. Rosier, B.T., P.D. Marsh, and A. Mira, Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis.J Dent Res, 2017. Advance online publication. doi: 10.1177/0022034517742139 de Steenhuijsen Piters, W.A., E.A. Sanders, and D. Bogaert, The role of the local microbial ecosystem in respiratory health and disease.Philos Trans R Soc Lond B Biol Sci, 2015. 370(1675). Bassis, C., et al., Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals.mBio, 2015. 6(2): p. e00037-15. Affoo, R.H., et al., Meta-analysis of salivary flow rates in young and older adults.Journal of the American Geriatrics Society, 2015. 63(10): p. 2142-2151. Vuotto, C., F. Longo, and G. Donelli, Probiotics to counteract biofilm-associated infections: promising and conflicting data.Int J Oral Sci, 2014. 6(4): p. 189-94. | Yes | Vanessa Cannaday - vcannaday@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudouRMTm1ouI7PCmk63QqJfpHmkh5p-TdbL_T3XdcAelEElPLKIv4Qaf21ZDGpMAJ0 | ||||
| 19/12/2019 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Translational Salivary Bioscience Research: The overall goal of this project is to systematically identify contributors to dysphagia and to develop novel interventions to prevent pneumonia onset in persons with Alzheimer’s disease. The focus of this position will be to perform experiments to characterize the salivary profiles and oral microbiome of patient samples, including running specific sialochemical analyses, protein characterization, and collaborating with our research partners to analyze the microbiome analysis results. ____________________________________________________________________________ Role - Depending on interests and timeframe of applicants, there is the potential to perform clinical research activities and contribute to the preparation of manuscripts.; IRB Status - Approved; Skills - High level communication skills and ability to collaborate effectively with other researchers. Experience performing biochemical experiments such as ELISAs and experience or willingness to learn data analysis techniques and manuscript writing. | 0 | npulia@wisc.edu | Nicole | Pulia | PhD, CCC-SLP | Nicole Pulia, npulia@wisc.edu -- Co-Mentor: | Assistant Professor | 1 | Geriatrics & Gerontology | Surgery | Otolaryngology - Head & Neck | Translational Salivary Bioscience Research | The overall goal of this project is to systematically identify contributors to dysphagia and to develop novel interventions to prevent pneumonia onset in persons with Alzheimer’s disease. The focus of this position will be to perform experiments to characterize the salivary profiles and oral microbiome of patient samples, including running specific sialochemical analyses, protein characterization, and collaborating with our research partners to analyze the microbiome analysis results. | Depending on interests and timeframe of applicants, there is the potential to perform clinical research activities and contribute to the preparation of manuscripts. | High level of independence, will be supported by Lab staff | High level communication skills and ability to collaborate effectively with other researchers. Experience performing biochemical experiments such as ELISAs and experience or willingness to learn data analysis techniques and manuscript writing. | Approved | Yes | Yes | Yes | PhD students | Rogus-Pulia, N.M., et al., Effects of Change in Tongue Pressure and Salivary Flow Rate on Swallow Efficiency Following Chemoradiation Treatment for Head and Neck Cancer.Dysphagia, 2016. 31(5): p. 687-96. Rogus-Pulia, N., et al., Effects of Device-Facilitated Isometric Progressive Resistance Oropharyngeal Therapy on Swallowing and Health-Related Outcomes in Older Adults with Dysphagia.J Am Geriatr Soc, 2016. 64(2): p. 417-24. Rogus-Pulia, N., et al., Salivary Quantity and Viscosity: Effects on Perceived Swallow Effort and Oropharyngeal Residue in Patients with Dysphagia, in Dysphagia Research Society. 2016: Tuscon, Arizona. p. 786-845. Rogus-Pulia, N.M., et al., A Pilot Study of Perceived Mouth Dryness, Perceived Swallowing Effort, and Saliva Substitute Effects in Healthy Adults Across the Age Range.Dysphagia, 2017. Advance online publication. doi: 10.1007/s00455-017-9846-7. Rogus-Pulia, N.M., et al., Changes in swallowing physiology and patient perception of swallowing function following chemoradiation for head and neck cancer.Dysphagia, 2014. 29(2): p. 223-33. Patel, D.A., et al., Economic and survival burden of dysphagia among inpatients in the United States.Dis Esophagus, 2017. Advance online publication. doi: 10.1093/dote/dox131. Scannapieco, F.A. and K. Shay, Oral health disparities in older adults: oral bacteria, inflammation, and aspiration pneumonia.Dent Clin North Am, 2014. 58(4): p. 771-82 Cabre, M., et al., Oropharyngeal dysphagia is a risk factor for readmission for pneumonia in the very elderly persons: observational prospective study.J Gerontol A Biol Sci Med Sci, 2014. 69(3): p. 330-7. Kilian, M., et al., The oral microbiome -an update for oral healthcare professionals.Br Dent J, 2016. 221(10): p. 657-666. Marsh, P.D., D.A. Head, and D.A. Devine, Ecological approaches to oral biofilms: control without killing.Caries Res, 2015. 49 Suppl 1: p. 46-54. Ortega, O., et al., High prevalence of colonization of oral cavity by respiratory pathogens in frail older patients with oropharyngeal dysphagia.Neurogastroenterol Motil, 2015. 27(12): p. 1804-16. Ortega, O., et al., Oral health in older patients with oropharyngeal dysphagia.Age and ageing, 2014. 43(1): p. 132-137. Robbins, J., et al., Age-Related Differences in Pressures Generated During Isometric Presses and Swallows by Healthy Adults.Dysphagia, 2016. 31(1): p. 90-6. Carrion, S., et al., Oropharyngeal dysphagia is a prevalent risk factor for malnutrition in a cohort of older patients admitted with an acute disease to a general hospital.Clin Nutr, 2015. 34(3): p. 436-42. Rosier, B.T., P.D. Marsh, and A. Mira, Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis.J Dent Res, 2017. Advance online publication. doi: 10.1177/0022034517742139 de Steenhuijsen Piters, W.A., E.A. Sanders, and D. Bogaert, The role of the local microbial ecosystem in respiratory health and disease.Philos Trans R Soc Lond B Biol Sci, 2015. 370(1675). Bassis, C., et al., Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals.mBio, 2015. 6(2): p. e00037-15. Affoo, R.H., et al., Meta-analysis of salivary flow rates in young and older adults.Journal of the American Geriatrics Society, 2015. 63(10): p. 2142-2151. Vuotto, C., F. Longo, and G. Donelli, Probiotics to counteract biofilm-associated infections: promising and conflicting data.Int J Oral Sci, 2014. 6(4): p. 189-94. | Yes | Vanessa Cannaday - vcannaday@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueCWneIRh_GLd3oGmWuET9ljZP10JKU_0ZxxqVAB2EciPCbv6grhNw09LpvK2NcyaE | ||||
| 19/12/2019 | Radiology | Have often had Shapiro students return for research elective, open to discussion of other research options | Abdominal radiology projects: (Drs. Lubner & Pickhardt will discuss a variety of potential projects with the prospective Shapiro student, and a mutual decision on a specific project will be made, reflecting interest, need, and feasibility.) 1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones 2. Radiomics/machine learning: Use software tools to extract radiomics features and correlate with pathologic and clinical outcomes, past examples include assessment of renal and pancreas lesions; could look at reproducibility, different software platforms, etc 3. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series, intrahep cca 4. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques, ex impact of use of oral contrast in ED, consequences of changing kV and impact on HU measurements 5. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 6. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 7. CT colonography related projects 8. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 9. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc 10. CT patient series clinical projects: stump appendicitis ____________________________________________________________________________ Role - Primary data collection, image analysis, abstract/manuscript preparation; IRB Status - approved; Skills - Basic knowledge of Microsoft office tools | 0 | mlubner@uwhealth.org | Meghan | Lubner | MD | Meghan Lubner, mlubner@uwhealth.org -- Co-Mentor: Perry J. Pickhardt, MD ppickhardt2@uwhealth.org | Associate professor | 608 | Abdominal Imaging and Intervention | Perry J. Pickhardt, MD | ppickhardt2@uwhealth.org | Radiology | Abdominal imaging and intervention | Abdominal radiology projects | (Drs. Lubner & Pickhardt will discuss a variety of potential projects with the prospective Shapiro student, and a mutual decision on a specific project will be made, reflecting interest, need, and feasibility.) 1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones 2. Radiomics/machine learning: Use software tools to extract radiomics features and correlate with pathologic and clinical outcomes, past examples include assessment of renal and pancreas lesions; could look at reproducibility, different software platforms, etc 3. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series, intrahep cca 4. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques, ex impact of use of oral contrast in ED, consequences of changing kV and impact on HU measurements 5. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 6. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 7. CT colonography related projects 8. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 9. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc 10. CT patient series clinical projects: stump appendicitis | Primary data collection, image analysis, abstract/manuscript preparation | Moderate | Basic knowledge of Microsoft office tools | approved | No | Rad R/D dept funds used in past years | Yes | Not currently available to mentor other students | Depends on the project. Here are some recent past examples of papers with Shapiro students: 1. Bannas, P., et al., Automated volumetric analysis for comparison of oral sulfate solution (SUPREP) with established cathartic agents at CT colonography (vol 40, pg 11, 2015). Abdominal Imaging, 2015. 40(6): p. 2066-2066. 2. Elissa, M., M.G. Lubner, and P.J. Pickhardt, Biopsy of Deep Pelvic and Abdominal Targets With Ultrasound Guidance: Efficacy of Compression. AJR Am J Roentgenol, 2019: p. 1-6. 3. Hunt, O.M.F., et al., The Liver Segmental Volume Ratio for Noninvasive Detection of Cirrhosis: Comparison With Established Linear and Volumetric Measures. Journal of Computer Assisted Tomography, 2016. 40(3): p. 478-484. 4. Kim, N.Y., et al., Utility of CT Texture Analysis in Differentiating Low-Attenuation Renal Cell Carcinoma From Cysts: A Bi-Institutional Retrospective Study. AJR Am J Roentgenol, 2019. 213(6): p. 1259-1266. 5. Lee, S.J., et al., Opportunistic screening for osteoporosis using the sagittal reconstruction from routine abdominal CT for combined assessment of vertebral fractures and density. Osteoporos Int, 2016. 27(3): p. 1131-1136. 6. Lubner, M.G., et al., Texture analysis of the liver at MDCT for assessing hepatic fibrosis. Abdom Radiol (NY), 2017. 42(8): p. 2069-2078. 7. Lubner, M.G., et al., CT Textural Analysis of Large Primary Renal Cell Carcinomas: Pretreatment Tumor Heterogeneity Correlates With Histologic Findings and Clinical Outcomes. American Journal of Roentgenology, 2016. 207(1): p. 96-105. 8. Lubner, M.G., et al., CT textural analysis of hepatic metastatic colorectal cancer: pre-treatment tumor heterogeneity correlates with pathology and clinical outcomes. Abdom Imaging, 2015. 40(7): p. 2331-7. 9. Lubner, M.G., et al., Volumetric Versus Unidimensional Measures of Metastatic Colorectal Cancer in Assessing Disease Response. Clin Colorectal Cancer, 2017. 16(4): p. 324-333 e1. 10. Patrick, J.L., et al., Objective volumetric comparison of room air versus carbon dioxide for colonic distention at screening CT colonography. Abdominal Imaging, 2015. 40(2): p. 231-236. 11. Pickhardt, P.J., et al., Volumetric Analysis of Colonic Distention According to Patient Position at CT Colonography: Diagnostic Value of the Right Lateral Decubitus Series. American Journal of Roentgenology, 2014. 203(6): p. W623-W628. 12. Pickhardt, P.J., et al., Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis. Eur Radiol, 2017. 27(7): p. 3060-3068. 13. Pickhardt, P.J., et al., Accuracy of Liver Surface Nodularity Quantification on MDCT as a Noninvasive Biomarker for Staging Hepatic Fibrosis. AJR Am J Roentgenol, 2016. 207(6): p. 1194-1199. 14. Scrima, A., et al., Abdominal Multidetector Computed Tomography for Suspected Small-Bowel Obstruction: Multireader Study Comparing Radiologist Performance for Predicting Surgical Outcomes. Journal of Computer Assisted Tomography, 2017. 41(3): p. 388-393. 15. Scrima, A., et al., Value of MDCT and Clinical and Laboratory Data for Predicting the Need for Surgical Intervention in Suspected Small-Bowel Obstruction. American Journal of Roentgenology, 2017. 208(4): p. 785-793. 16. Scrima, A.T., et al., Texture analysis of small renal cell carcinomas at MDCT for predicting relevant histologic and protein biomarkers. Abdominal Radiology, 2019. 44(6): p. 1999-2008. | No | NA | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuczu9uXd4oWOL18psVojE9sMnfV4U3nlyoUCfPfR-aKNpYMHh1VkYKPfS4vPtZEOg0 | ||
| 19/12/2019 | Medicine | Research Electives for credit | Hepatitis B vaccine immunogenicity in patients with IBD: Evaluating the immunogenicity of the new hepatitis B vaccine in patients with inflammatory bowel disease who are immunosuppressed and evaluating vaccine response rate. Primary outcome evaluating seroconversion rate. ____________________________________________________________________________ Role - Data collection; IRB Status - QI project ; Skills - review medical records | 1 | fcaldera@medicine.wisc.edu | Freddy | Caldera | DO,MS | Freddy Caldera, fcaldera@medicine.wisc.edu -- Co-Mentor: Mary Hayney mary.hayney@wisc.edu | Assistant Professor of Medicine | 608 | Gastroenterology & Hepatology | Mary Hayney | mary.hayney@wisc.edu | Other | School of Pharmacy | Hepatitis B vaccine immunogenicity in patients with IBD | Evaluating the immunogenicity of the new hepatitis B vaccine in patients with inflammatory bowel disease who are immunosuppressed and evaluating vaccine response rate. Primary outcome evaluating seroconversion rate. | Data collection | able to review medial records and data collection in excel. | review medical records | QI project | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students | 1. Caldera F, Hillman L, Saha S, Wald A, Grimes I, Zhang Y, Sharpe AR, Reichelderfer M, Hayney MS. Immunogenicity of High Dose Influenza Vaccine for Patients with Inflammatory Bowel Disease on Anti-TNF Monotherapy: A Randomized Clinical Trial.Inflamm Bowel Dis. 2019 Aug 24. pii: izz164. doi: 10.1093/ibd/izz164. [Epub ahead of print] 2. Ley D, Hayney MS, Caldera F. Third Time's a Charm: Immunization Strategies for Hepatitis B in Immunosuppressed Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Jul;64(7):1738-1739. 3. Caldera F, Misch EA, Saha S, Wald A, Zhang Y, Hubers J, Megna B, Ley D, Reichelderfer M, Hayney MS. Immunosuppression Does Not Affect Antibody Concentrations to Measles, Mumps, and Rubella in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Jan;64(1):189-195 4. Caldera F, Saha S, Wald A, Garmoe CA, McCrone S, Megna B, Ley D, Reichelderfer M, Hayney MS. Lower Sustained Diphtheria and Pertussis Antibody Concentrations in Inflammatory Bowel Disease Patients. Dig Dis Sci. 2018 Jun;63(6):1532-1540. | No | Lindsay Luedke GI reserach manager leluedke@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueZvsow_Du2N_sIfCh59Z6o18GZ301D6HIAp5yVbktJkSNkFigFqsNpgJfSn4ynRs4 | ||
| 20/12/2019 | Medicine | Shorter term projects | Risk factor and outcomes of post-transplant eryhtrocytosis after kidney transplant : Anemia is very common among patients with kidney failure. However, after successful kidney transplant around 15-20% develop post transplant erythrocytosis (PTE) ( High Hemoglobin and hematocrit). Risk factors for PTE and its effects on the kidney graft or patient is unknown. Most of the studies are more than 10-15 years old. ____________________________________________________________________________ Role - Student will serve as a first author in this project. S/he will coordinate with Dr. Brad Astor to get data from our huge transplant database ( no chart review needed), prepare abstract and if accepted present in the American Society of Nephrology (ASN) in fall of 2020. And ultimately prepare and publish the paper. ; IRB Status - Will be approved in Mid January ; Skills - Not partcular- just need energy and enthusisam | 0 | sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: | Assistant professor | 6.082.650.152 | Nephrology | Transplant | Risk factor and outcomes of post-transplant eryhtrocytosis after kidney transplant | Anemia is very common among patients with kidney failure. However, after successful kidney transplant around 15-20% develop post transplant erythrocytosis (PTE) ( High Hemoglobin and hematocrit). Risk factors for PTE and its effects on the kidney graft or patient is unknown. Most of the studies are more than 10-15 years old. | Student will serve as a first author in this project. S/he will coordinate with Dr. Brad Astor to get data from our huge transplant database ( no chart review needed), prepare abstract and if accepted present in the American Society of Nephrology (ASN) in fall of 2020. And ultimately prepare and publish the paper. | none | Not partcular- just need energy and enthusisam | Will be approved in Mid January | No | May be Department of Medicine will cover. | Yes | Not currently available to mentor other students | https://www.ncbi.nlm.nih.gov/pubmed/29954763 https://www.ncbi.nlm.nih.gov/pubmed/8023814- old one | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueFmA1aH4m_zN4chW4w_V4l_8mN1VSmA3gbqrFn3cr1vCqa7qTe7ULf8klvWnYm6KY | |||||
| 20/12/2019 | Medicine | Shorter term projects | Predictor of BK Viremia progression and developement of BK nephropathy : BK virus is one of the most common opportunistic viral infection among kidney transplant recipients. BK nephropathy is serious complication and can lead to kidney graft loss. Till date, there is no effective treatment for BK viremia and only management is decreasing immunosuppressive medication. Despite decreasing immunos, some patients continue and progress to have severe BK viremia or even nephropathy, while some clear without any other complication- while other develop rejection. We are planning to design this as a prospective study among kidney transplant recipients transplanted in 2015-2017: who had progressive BK viremia 2 years post transplant. ____________________________________________________________________________ Role - Student will be the first author and PI in this study, will need some chart review in health link ( Epic). Will submit abstract to American Society of Nephrology (ASN) and if accepted student will present their work there. Ultimate plan is to publish manuscript in the reputed journal. ; IRB Status - Will be approved in Mid Jan 2020 ; Skills - None- just need energy and enthusisam | 0 | sparajuli@medicine.wisc.edu | sandesh | parajuli | MD | sandesh parajuli , sparajuli@medicine.wisc.edu -- Co-Mentor: | Assistant professor | 6.082.650.152 | Nephrology | Medicine | Transplant | Predictor of BK Viremia progression and developement of BK nephropathy | BK virus is one of the most common opportunistic viral infection among kidney transplant recipients. BK nephropathy is serious complication and can lead to kidney graft loss. Till date, there is no effective treatment for BK viremia and only management is decreasing immunosuppressive medication. Despite decreasing immunos, some patients continue and progress to have severe BK viremia or even nephropathy, while some clear without any other complication- while other develop rejection. We are planning to design this as a prospective study among kidney transplant recipients transplanted in 2015-2017: who had progressive BK viremia 2 years post transplant. | Student will be the first author and PI in this study, will need some chart review in health link ( Epic). Will submit abstract to American Society of Nephrology (ASN) and if accepted student will present their work there. Ultimate plan is to publish manuscript in the reputed journal. | None- just need energy and enthusisam | Will be approved in Mid Jan 2020 | No | Department of Medicine may cover 50% | Yes | Not currently available to mentor other students | https://jasn.asnjournals.org/content/26/4/966 https://www.ncbi.nlm.nih.gov/pubmed/31071208 | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf8hqji8sO7F6IFaBG9tzT5_5QfTCXUTqgDdSAm3ZDv2tYQJfNGigl34UMI5RWnmuY | |||||
| 20/12/2019 | Human Oncology | Shorter term projects, Research Electives for credit | Deep learning in the treatment of breast cancer: Artificial intelligence is already changing radiology and pathology and will soon find applications in all medical specialties. AI algorithms are now easily accessible to researchers without a computer science degree and can be applied to novel problems. The goal of this project is to automatically identify and outline the post-operative bed of breast cancer patients. The post-op bed outline is then used to inform radiation therapy plans to reduce the chance of local recurrence. ____________________________________________________________________________ Role - Work in a team of radiation oncologists, physicists, and computer scientists to compile a database of images and relevant clinical information. Imaging modalities may include CT, MRI, and cone beam CT. We will have a GPU workstation available in the Department of Human Oncology. Computer scientist collaborators will be available to provide expertise in order to run AI training scripts and identify optimal deep learning solutions. The goal is that the results will lead to presentations and publications.; IRB Status - IRB will be required.; Skills - Prefer individuals with experience in programming but this is not a requirement. Python is a plus. Interest in imaging, oncology and/or AI. | 1 | lee954@wisc.edu | Sangjune | Lee | MD MSE | Sangjune Lee, lee954@wisc.edu -- Co-Mentor: Bethany Anderson anderson@humonc.wisc.edu | Clinical Fellow in Radiation Oncology | 608 | Radiation Oncology | Bethany Anderson | anderson@humonc.wisc.edu | Human Oncology | Radiation Oncology | Deep learning in the treatment of breast cancer | Artificial intelligence is already changing radiology and pathology and will soon find applications in all medical specialties. AI algorithms are now easily accessible to researchers without a computer science degree and can be applied to novel problems. The goal of this project is to automatically identify and outline the post-operative bed of breast cancer patients. The post-op bed outline is then used to inform radiation therapy plans to reduce the chance of local recurrence. | Work in a team of radiation oncologists, physicists, and computer scientists to compile a database of images and relevant clinical information. Imaging modalities may include CT, MRI, and cone beam CT. We will have a GPU workstation available in the Department of Human Oncology. Computer scientist collaborators will be available to provide expertise in order to run AI training scripts and identify optimal deep learning solutions. The goal is that the results will lead to presentations and publications. | Self directed learning and motivation required. Weekly meetings and mentoring will be provided. | Prefer individuals with experience in programming but this is not a requirement. Python is a plus. Interest in imaging, oncology and/or AI. | IRB will be required. | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Improved dosimetric accuracy with semi-automatic contour propagation of organs-at-risk in glioblastoma patients undergoing chemoradiation. J Appl Clin Med Phys Lee S, Stewart J, Lee Y, Myrehaug S, Sahgal A, Ruschin M, Tseng CL 2019 Oct 31; : Extensive Unpredictable Pancreas Cancer Inter-fraction Motion: A Case Report. Cureus Lee SL, Velec M, Munoz-Schuffenegger P, Stanescu T, Dawson L 2019 Jun 30; 11 (6): e5047 | Yes | Julie Thomas |
https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuewgwZGTZep22TxYS4yvaMcOwaw0Jz7qR4HyMNXJbw5hVSWzhVrQwnB5Hf_SR3W5z8 | ||
| 11/01/2020 | Orthopedics and Rehabilitation | Shorter term projects | Blue Light Therapy Reduces Cutibacterium Acnes Bioburden at the Deltopectoral Interval : We plan on looking at the use of blue light and a topical medication before surgery to decrease the risk of C. acnes infection. We have other projects that the student could potentially assist with as well. ____________________________________________________________________________ Role - Collect data, assist with manuscript preparation; IRB Status - In preparation for submission; Skills - Enthusiasm, strong work ethic | 0 | grogan@ortho.wisc.edu | Brian | Grogan | MD | Brian Grogan, grogan@ortho.wisc.edu -- Co-Mentor: | Assistant Professor Shoulder, Elbow, and Sports Medicine Department of Orthopedics and Rehabilitation University of Wisconsin School of Medicine and Public Health | 6.082.257.832 | Sports Medicine | Blue Light Therapy Reduces Cutibacterium Acnes Bioburden at the Deltopectoral Interval | We plan on looking at the use of blue light and a topical medication before surgery to decrease the risk of C. acnes infection. We have other projects that the student could potentially assist with as well. | Collect data, assist with manuscript preparation | Student will work independently and in collaboration with residents and staff | Enthusiasm, strong work ethic | In preparation for submission | Applying for ASES grants as well as department funding | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | I have many ongoing projects, but this is the first in this area. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue9CJ-HTbCf7X6ViDVFHs0LpCQDTJ4VC0HCq2Nmy_9_iKHYcvp5Sl80fUl4oEaJXMw | ||||||
| 22/12/2019 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Effects of Infectious Disease Consultation on Nursing Home Discharge-Related Outcomes: We are looking for one or two students who are interested in helping us complete a project focused on understanding the impact of the infectious disease (ID) consult service on the discharge of hospitalized patients to the nursing home setting. My research group is focused on characterizing patterns and determinants of antibiotic use and developing, implementing and evaluating interventions to reduce the risk of harms from both necessary as well as unnecessary antibiotic use in nursing homes. We are currently involved in a multi-site project to better understand antibiotic prescribing at the transition between the hospital and nursing home setting. Our preliminary work on this project has shown that the ID service, which often plays a critical role in helping inpatient teams optimally treat hospitalized patients, can contribute to delays in the discharge of patients to nursing homes when recommendations are not timely or result in the use of expensive antibiotics that may make nursing homes more hesitant to accept the referral. A better understanding of the impact of the ID service practice on inpatients being discharged to the nursing home will help us better understand how to improve ID consultative services and ID service treatment recommendations for patients being discharged to a nursing home. Students working on this project will be involved in primary data collection (i.e., chart reviews), data entry and management, and working with other project team members to analyze, present and write up study results. We anticipate this study will result in opportunities to present at national infectious disease meetings as well as at least one peer-reviewed manuscript. Interested students should contact Sally Jolles (sajolles@medicine.wisc.edu) to set up time to discuss the project. ____________________________________________________________________________ Role - Students will be performing retrospective chart abstraction, data entry (into REDCap), and basic data analyses (descriptive statistics). ; IRB Status - Currently under development; Skills - Familiarity with the UW Hospital health record (not essential), basic knowledge of excel and powerpoint | 2 | cjc@medicine.wisc.edu | Christopher | Crnich | MD PhD | Christopher Crnich, cjc@medicine.wisc.edu -- Co-Mentor: Sally Jolles sajolles@medicine.wisc.edu | Associated Professor of Medicine | 6.082.807.055 | Infectious Disease | Sally Jolles | sajolles@medicine.wisc.edu | Medicine | Infectious Disease | Effects of Infectious Disease Consultation on Nursing Home Discharge-Related Outcomes | We are looking for one or two students who are interested in helping us complete a project focused on understanding the impact of the infectious disease (ID) consult service on the discharge of hospitalized patients to the nursing home setting. My research group is focused on characterizing patterns and determinants of antibiotic use and developing, implementing and evaluating interventions to reduce the risk of harms from both necessary as well as unnecessary antibiotic use in nursing homes. We are currently involved in a multi-site project to better understand antibiotic prescribing at the transition between the hospital and nursing home setting. Our preliminary work on this project has shown that the ID service, which often plays a critical role in helping inpatient teams optimally treat hospitalized patients, can contribute to delays in the discharge of patients to nursing homes when recommendations are not timely or result in the use of expensive antibiotics that may make nursing homes more hesitant to accept the referral. A better understanding of the impact of the ID service practice on inpatients being discharged to the nursing home will help us better understand how to improve ID consultative services and ID service treatment recommendations for patients being discharged to a nursing home. Students working on this project will be involved in primary data collection (i.e., chart reviews), data entry and management, and working with other project team members to analyze, present and write up study results. We anticipate this study will result in opportunities to present at national infectious disease meetings as well as at least one peer-reviewed manuscript. Interested students should contact Sally Jolles (sajolles@medicine.wisc.edu) to set up time to discuss the project. | Students will be performing retrospective chart abstraction, data entry (into REDCap), and basic data analyses (descriptive statistics). | Students will be directly supervised by Sally Jolles (Researcher) but will be expected to be able to perform chart abstraction and data entry independently after undergoing initial training. | Familiarity with the UW Hospital health record (not essential), basic knowledge of excel and powerpoint | Currently under development | Yes | Yes | DOM has traditionally provided the 50% matching on behalf of PIs | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Jump RLP, Heath B, Crnich CJ, Moehring R, Schmader KE, Olds D, Higgins PA. Knowledge, beliefs, and confidence regarding infections and antimicrobial stewardship: a survey of Veterans Affairs providers who care for older adults. Am J Infect Control 2015; 43(3): 298-300. PMID: 25728158. Mody L, Crnich C. Effects of excessive antibiotic use in nursing homes. JAMA Intern Med 2015; 175(8): 1339-41. PMID: 26121096. Crnich CJ, Jump R, Trautner B, Sloane PD, Mody L. Optimizing Antibiotic Stewardship in Nursing Homes: A Narrative Review and Recommendations for Improvement. Drugs Aging. 2015; 32(9): 699-716. PMID: 26316294; PMCID: PMC4579247. Heath B, Bernhardt J, Michalski TJ, Crnich CJ, Moehring R, Schmader KE, Olds D, Higgins PA, Jump RL. Results of a Veterans Affairs employee education program on antimicrobial stewardship for older adults. Am J Infect Control. 2015; 44(3): 349-51. PMID: 26553404. Batina NG, Crnich CJ, Anderson DF, Dopfer DDV. Models to predict prevalence and transition dynamics of methicillin-resistant staphylococcus aureus in community nursing homes. Am J Infect Control 2016; 44(5): 507-14. PMID 26777286 Jump RL, Crnich CJ, Nace DA. Cloudy, foul-smelling urine not criteria for diagnosis of urinary tract infection in older adults. J Am Med Dir Assoc 2016; 17(8): 754. PMID: 27217095 Eke-Usim AC, Rogers MA, Gibson KE, Crnich C, Mody L. Constitutional symptoms trigger diagnostic testing before antibiotic prescribing in high-risk nursing home residents. J Am Geriatr Soc 2016; 64(10): 1975-80. PMID: 27655061 Batina NG, Crnich CJ, Anderson DF, Dopfer DDV. Identifying conditions for elimination and epidemic potential of methicillin-resistant Staphylococcus aureus in community nursing homes. Antimicrob Res Infect Control 2016; 5:32. PMID: 27688877 Dumyati G, Stone ND, Nace DA, Crnich CJ, Jump RL. Challenges and strategies for prevention of multidrug-resistant organism transmission in nursing homes. Curr Infect Dis Rep 2017; 19(4): 18. PMID: 28382547 Crnich CJ, Jump RL, Nace DA. Improving management of urinary tract infections in older adults: a paradigm shift or therapeutic nihilism? J Am Geriatr Soc 2017; 65(8): 1661-3. PMID: 28653467 Jump RLP, Gaur S, Katz MJ, Crnich CJ, Dumyati G, Ashraf MS, Frenztel E, Schweon SJ, Sloane P, Nace D. Template for an antibiotic stewardship policy for post-acute and long-term care settings. J Am Med Dir Assoc 2017; 18(11): 913-20. PMID: 289355515; PMCID: PMC5839140 McElligott M, Welham G, Pop-Vicas A, Taylor L, Crnich CJ. Antibiotic stewardship in nursing facilities. Infect Dis Clin North Am. 2017 31(4):619-638. PMID: 29079152 Batina NG, Crnich CJ, Döpfer D. Acquisition and persistence of strain-specific methicillin-resistant Staphylococcus aureus and their determinants in community nursing homes. BMC Infect Dis. 2017; 17(1):752. PMID: 29212459; PMCID: PMC5719525 Van Buul LW, Vreeken HL, Bradley SF, Crnich CJ, Drinka PJ, Geerlings SE, Jump RLP, Mody L, Mylotte JJ, Loeb M, Nace DA, Nicolle LE, Sloane PD, Stuart RL, Sundvall PD, Ulleryd P, Veenhuizen RB, Hertogh CMPM. The development of a decision tool for the empiric treatment of suspected urinary tract infection in frail older adults: a Delphi consensus procedure. J Am Med Dir Assoc 2018; 19(9): 757-64. PMID 29910137. Pulia M, Kern M, Schwei RJ, Shah MN, Sampene E, Crnich CJ. Comparing appropriateness of antibiotics for nursing home residents by setting of prescription initiation: a cross-sectional analysis. Antimicrob Resist Infect Control 2018;14(7): 74. PMID 29946449. Nace DA, Perera SK, Hanlon JT, Saracco S, Anderson G, Schweon SJ, Klein-Fedyshin M, Wessel CB, Mulligan M, Drinka PJ, Crnich CJ. The improving the outcomes of UTI in long-term care project (IOU) consensus guidelines for the diagnosis of uncomplicated cystitis in nursing home residents. J Am Med Dir Assoc 2018; 19(9): 765-769. PMID 30037743. Stevenson LD, Banks RE, Stryczek KC, Crnich CJ, Ide EM, Wilson BM, Viau RA, Ball SL, Jump RLP. A pilot study using telehealth to implement antimicrobial stewardship at two rural Veterans Affairs medical centers. Infect Control Hosp Epidemiol 2018; 39(10): 1163-9. PMID: 30185238. Weber BR, Noble BN, Bearden DT, Crnich CJ, Ellingson KD, McGregor JC, Furuno JP. Antibiotic prescribing upon discharge from the hospital to long-term care facilities: Implications for antimicrobial stewardship requirements in post-acute settings. Infect Control Hosp Epidemiol 2019; 40(1): 18-23. PMID: 30409235. Hanlon JT, Perera S, Drinka PJ, Crnich CJ, Schweon SJ, Klein-Fedyshin M, Wessel CB, Saracco S, Anderson G, Mulligan M, Nace DA. The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents. J Am Geriatr Soc 2018; 67(3): 539-45. PMID: 30584657. Wilson BM, Banks RE, Crnich CJ, Ide E, Viau RA, El Chakhtoura NG, Jones YR, Cherry JB, Anderson BA Jump RLP. Changes in antibiotic use following implementation of a telehealth stewardship pilot program. Infect Control Hosp Epidemiol 2019; 40: 810-14. PMID: 31172905. Appaneal HJ, Caffrey AR, Lopes VV, Crnich CJ, Dosa DM, LaPlante KL. National trends in the treatment of urinary tract infections among Veterans’ Affairs Community Living Center residents. Infect Control Hosp Epidemiol 2019; 40: 1087-93. PMID: 31354115. Davenport C, Brodeur M, Wolff M, Meek PD, Crnich CJ. Decisional guidance tool for antibiotic prescribing in the skilled nursing facility. J Am Geriatr Soc 2019; epub ahead of print. PMID: 31463933. Ford JH, Vranas L, Coughlin D, Selle KM, Nordman-Oliveira S, Ryther B, Ewers T, Griffin TL, Eslinger A, Boero J, Hardgrove P, Crnich CJ. Effect of a standard vs enhanced implementation strategy to improve antibiotic prescribing in nursing homes: a trial protocol of the improving management of urinary tract infections in nursing institutions through facilitated implementation (IMUNIFI) study. JAMA Netw Open 2019; 4: e199526. PMID: 31509204. | Yes | Sally Jolles (sajolles@medicine.wisc.edu) Steve Marshal (samarsh@medicine.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud_3pkd4Ab3Kp4mMVVRRAhnJsgcZHMeFohoRucNDOODDCwO2bbsn7Zotd5IhaAmdtM | ||
| 23/12/2019 | Medicine | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD, MPH: The goal of the study is investigating the impact of Belatacept compared to Calcinurine Inhibitors on Kidney Transplant and patient Outcome: cardiovascular disease (CVD) is a major risk of death after kidney transplantation. Right-side Congestive Heart failure (CHF) and Pulmonary Hypertension (PHTN) are important prognostic outcome factors. Manifestations of CVD after kidney transplantation present primarily as ischemic and CHF events. Belatacept is first-in-class co-stimulation blocker non-nephrotoxic maintenance immunosuppressive medication. Calcineurin inhibitors (CNI) like tacrolimus and Cyclosporine which are commonly used maintenance immunosuppressive medications are known for their nephrotoxicity and being potential contributor of volume overload and chronic kidney disease (CKD) progression after kidney transplantation. Optimal strategies for better management of recipients with RCHF and PHTN will need to be determined. ____________________________________________________________________________ Role - Work with a team of Transplant Pharmacist and cardiology attending for project design, literature research, data analysis, and writing and become the primary author of the abstract and manuscript.; IRB Status - PI will obtain IRB and it will be ready before the research; Skills - no skills required | 1 | mmohamed2@wisc.edu | Maha | Mohamed | MD | Maha Mohamed, mmohamed2@wisc.edu -- Co-Mentor: Brad Astor bcastor@medicine.wisc.edu | Associate Professor | 3.019.967.780 | Division of Nephrology | Brad Astor | bcastor@medicine.wisc.edu | Population Health Sciences | Nephrology | PhD, MPH | The goal of the study is investigating the impact of Belatacept compared to Calcinurine Inhibitors on Kidney Transplant and patient Outcome: cardiovascular disease (CVD) is a major risk of death after kidney transplantation. Right-side Congestive Heart failure (CHF) and Pulmonary Hypertension (PHTN) are important prognostic outcome factors. Manifestations of CVD after kidney transplantation present primarily as ischemic and CHF events. Belatacept is first-in-class co-stimulation blocker non-nephrotoxic maintenance immunosuppressive medication. Calcineurin inhibitors (CNI) like tacrolimus and Cyclosporine which are commonly used maintenance immunosuppressive medications are known for their nephrotoxicity and being potential contributor of volume overload and chronic kidney disease (CKD) progression after kidney transplantation. Optimal strategies for better management of recipients with RCHF and PHTN will need to be determined. | Work with a team of Transplant Pharmacist and cardiology attending for project design, literature research, data analysis, and writing and become the primary author of the abstract and manuscript. | Student will be mentored and independence given as per the student comfort and experience | no skills required | PI will obtain IRB and it will be ready before the research | No | Department of Medicine will provide funding | Yes | MPH students | 1. Rigatto et al. Congestive heart Failure in renal Transplant: Risk Factors, Outcomes, and Relationship with Ischemic heart Disease. JASN, 2002. 2. Lentine et al. De novo congestive heart failure after kidney transplantation: a common condition with poor prognostic implications. AJKD 2005. 3. Siedelcki et al. The Impact of Left Ventricular Systolic Dysfunction on Survival After renal transplant. transplantation, 2007. 4. Issa et al. Pulmonary hypertension is associated with reduced patient survival after kidney transplantation. transplantation, 2008. 5. Vincenti et al. Five-Years Safety and Efficacy of Belatacept in Renal Transplantation. JASN 2010. 6. Naesens et al. Calcinurine Inhibitors Nephrotoxicity. CJASN 2009. | Yes | Samantha Strennen. sjthomps@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucY-sO3jYhKNu1PFeofImTiCNKoag0Bo51_4oijDXUBfP9SeaiC4OqUFn2LL-reYUE | ||
| 23/12/2019 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Cardiac ryanodine receptors and arrhythmias: We study how congenital mutations in the cardiac ryanodine receptor, a calcium channel of the sarcoplasmic reticulum, lead to cardiac arrhythmias and sudden cardiac death. Students will participate an array of multidisciplinary techniques, from molecular, to cellular, to whole organ and intact animal techniques. ____________________________________________________________________________ Role - Participate and learn laboratory techniques to get full immersion in a scientific project related to io channels and cardiac arrhythmias. ; IRB Status - N/A.; Skills - Basic laboratory ettiquette | 0 | hvaldivia@wisc.edu | Hector | Valdivia | MD, PhD | Hector Valdivia, hvaldivia@wisc.edu -- Co-Mentor: Francisco Alvarado, PhD falvarad@medicine.wisc.edu | Professor | 608 | Cardiology | Cell and Regenerative Biology | Francisco Alvarado, PhD | falvarad@medicine.wisc.edu | Medicine | Cardiology | Cardiac ryanodine receptors and arrhythmias | We study how congenital mutations in the cardiac ryanodine receptor, a calcium channel of the sarcoplasmic reticulum, lead to cardiac arrhythmias and sudden cardiac death. Students will participate an array of multidisciplinary techniques, from molecular, to cellular, to whole organ and intact animal techniques. | Participate and learn laboratory techniques to get full immersion in a scientific project related to io channels and cardiac arrhythmias. | Some previous laboratory experience preferred but not required | Basic laboratory ettiquette | N/A. | Yes | Yes | Yes | PhD students | Kim JC, Pérez-Hernández Duran M, Alvarado FJ, Maurya SR, Montnach J, Yin Y, Zhang M, Lin X, Vasquez C, Heguy A, Liang FX, Woo SH, Morley GE, Rothenberg E, Lundby A, Valdivia HH, Cerrone M, Delmar M. Disruption of Ca2+i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice. Circulation. 2019 Sep 17;140(12):1015-1030. Alvarado FJ, Bos JM, Yuchi Z, Valdivia CR, Hernandez JJ, Zhao YT, Henderlong DS, Chen Y, Booher TR, Marcou CA, Van Petegem F, Ackerman MJ, Valdivia HH (2019) Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2. JCI Insight. 2019;5. pii: 126544. doi: 10.1172/jci.insight. Potenza DM, Janicek R, Fernandez-Tenorio M, Camors E, Ramos-Mondragón R, Valdivia HH, Niggli E (2018) Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response. J Gen Physiol. 2019;151(2):131-145. Avula UMR, Hernandez JJ, Yamazaki M, Valdivia CR, Chu A, Rojas-Pena A, Kaur K, Ramos-Mondragón R, Anumonwo JM, Nattel S, Valdivia HH, Kalifa J. (2018) Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release. Circ Arrhythm Electrophysiol. 2018 Mar;11(3):e005659. Zhao YT, Valdivia CR, Gurrola GB, Powers PP, Willis BC, Moss RL, Jalife J, Valdivia HH. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function. Proc Natl Acad Sci USA. 2015; 112(13):E1669-77. | Yes | N/A. | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudGGxZlbVaPshlJpWUn7JzPDR1qRLcrexfL3YPXr_j41Lm4Gd2d1RVGKINhmrCEroI | |
| 14/01/2020 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Sharing doctors' notes to engage families of hospitalized children : Family engagement in care is critical to providing high quality and safe care to pediatric patients. Our research focuses on leveraging innovative tools and technologies to more effectively partner with families in the care of their children. Expanding on the success of previous students and our team, we will work with a student to develop a project that best suits their interests and skills. Previous projects include: analysis of parent and staff surveys, interpretation of interview data, grant preparation and literature reviews. During this process, the student will have the opportunity to develop abstract, presentation, and manuscript writing skills, collaborate with our research teams in Pediatrics and present their work to clinician, research, parent and other community stakeholders. ____________________________________________________________________________ Role - Develop with the mentor a project with clear and achievable goals and then execute the project in accordance with the timeline.; IRB Status - Depends on specific project chosen; Skills - Must be reliable, punctual, organized, good communicator and proficient at Microsoft word and excel. | 0 | michelle.kelly@wisc.edu | Michelle | Kelly | MD, MS | Michelle Kelly, michelle.kelly@wisc.edu -- Co-Mentor: | Associate Professor | Hospital Medicine | Sharing doctors' notes to engage families of hospitalized children | Family engagement in care is critical to providing high quality and safe care to pediatric patients. Our research focuses on leveraging innovative tools and technologies to more effectively partner with families in the care of their children. Expanding on the success of previous students and our team, we will work with a student to develop a project that best suits their interests and skills. Previous projects include: analysis of parent and staff surveys, interpretation of interview data, grant preparation and literature reviews. During this process, the student will have the opportunity to develop abstract, presentation, and manuscript writing skills, collaborate with our research teams in Pediatrics and present their work to clinician, research, parent and other community stakeholders. | Develop with the mentor a project with clear and achievable goals and then execute the project in accordance with the timeline. | Moderate independence with frequent check ins and mentorship by faculty. | Must be reliable, punctual, organized, good communicator and proficient at Microsoft word and excel. | Depends on specific project chosen | No | Yes | Yes | MPH students | Kelly MM, Hoonakker P, Dean SM. Using an inpatient portal to engage families in pediatric hospital care. JAMIA. 2017 Jan;24(1):153-61. Cox ED, Jacobsohn GC, Rajamanickam VP, Carayon P, Kelly MM, Wetterneck TB, Rathouz PJ, Brown RL. A family-centered rounds checklist, family engagement, and patient safety: A randomized trial. Pediatrics. 2017 Apr;139(5):e20161688. Kelly MM, Coller RJ, Hoonakker PLT. Inpatient portals for hospitalized patients and caregivers: A systematic review. J Hosp Med. 2018 Jun;13(6):405-12. Kelly MM, Thurber AS, Coller RJ, Khan A, Dean SM, Smith W, Hoonakker, PLT. Parent perceptions of real-time access to their hospitalized child's medical records using an inpatient portal: A qualitative study. Hosp Pediatr. 2019 Apr;9(4):273-280. Arnott Smith C, Coller RJ, Dean SM, Sklansky DJ, Hoonakker PLT, Smith W, Thurber AS, Kelly MM. Parent perspectives on pediatric inpatient OpenNotes. AMIA’s 2019 Annual Symposium, in press Sharing doctors' inpatient notes with parents of hospitalized children: A pilot study, in preparation | No | Gemma Warner | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucxVWmZ5IuSEKw3CUPJ2EZk8IWF8fBBzoUeB3sXL2HwsBsPKiHODwuCTpRdvICLCoo | |||||||
| 26/12/2019 | Human Oncology | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Clinical evaluation of liver treatments with maximum inhale breath hold with ViewRay’s MR Systems (Cobalt/Linac): Background During the course of the last five years a cohort of liver patients were treated using ViewRay’s MRI guidance. It has a unique feature to adapt clinical treatment plan for changes in anatomy allowing dose escalation. In these treatments the gross tumor volume (GTV) was assigned as the tracking structure for maximum inhale breath hold (MIBH) MR-gated delivery. When tracking structure exceeds set percentage of the boundary volume (3.0-mm uniform expansion), the beam was automatically turned off. The utilization of MR-guided gated MIBH allowed for a reduction of the planning target volume (PTV) margin compared to the CBCT-based plans, delivered under shallow breathing with abdominal compression. Moreover, literature shows that dose escalation improves local control. Thus, treating with MIBH helps reduce dose to organs at risk (OARs) and allows escalation of the dose to the tumor. Additionally, MR scans are known to have better soft tissue contrast and these scans with contrast agent Evoist renders better visualization of the tumor and OARs. Materials and method ViewRay’s treatment delivery system has its own dedicated data base where all images, treatment plans and delivery plans are archived. Initial images (CT and MRI) and dosimetric data can be retrieved from MIM software. Some of the key steps in this study are: 1. Compile dosimetric data for planning target volume (PTV) and OARs 2. Segment GTV on fractional scan for radiomics analysis and evaluate response to treatment 3. Compare predicted, re-optimized and delivered dose using ViewRay treatment planning system (TPS) and document statistical significance 4. Determine overall survival, progression free survival and local control from the attending care provider assessments 5. Assess toxicity in the series of patients treated on ViewRay delivered 15 or 5 fractions ____________________________________________________________________________ Role - This study involves working with a team of radiation oncologists and physicists. It is a retrospective review of dosimetric and clinical outcomes of liver patients treated with maximum inhale breath hold on ViewRay. Students, depending upon their interest and skill sets, will have opportunity to work on any of the four steps described above. In particular the student participant in the study will work with a multidisciplinary group of staff and faculty to compile and analyze the clinical data for liver patients treated with MRI guided radiation treatments and contribute to the preparation of a publishable document (abstract, poster, article).; IRB Status - In place; Skills - Interested in Radiation oncology, imaging and Radiation therapy planning | 1 | yadav@humonc.wisc.edu | Poonam | Yadav | PhD | Poonam Yadav, yadav@humonc.wisc.edu -- Co-Mentor: Bhudatt R Paliwal paliwal@humonc.wisc.edu | Assistant Professor | 608 | Bhudatt R Paliwal | paliwal@humonc.wisc.edu | Human Oncology | Clinical evaluation of liver treatments with maximum inhale breath hold with ViewRay’s MR Systems (Cobalt/Linac) | Background During the course of the last five years a cohort of liver patients were treated using ViewRay’s MRI guidance. It has a unique feature to adapt clinical treatment plan for changes in anatomy allowing dose escalation. In these treatments the gross tumor volume (GTV) was assigned as the tracking structure for maximum inhale breath hold (MIBH) MR-gated delivery. When tracking structure exceeds set percentage of the boundary volume (3.0-mm uniform expansion), the beam was automatically turned off. The utilization of MR-guided gated MIBH allowed for a reduction of the planning target volume (PTV) margin compared to the CBCT-based plans, delivered under shallow breathing with abdominal compression. Moreover, literature shows that dose escalation improves local control. Thus, treating with MIBH helps reduce dose to organs at risk (OARs) and allows escalation of the dose to the tumor. Additionally, MR scans are known to have better soft tissue contrast and these scans with contrast agent Evoist renders better visualization of the tumor and OARs. Materials and method ViewRay’s treatment delivery system has its own dedicated data base where all images, treatment plans and delivery plans are archived. Initial images (CT and MRI) and dosimetric data can be retrieved from MIM software. Some of the key steps in this study are: 1. Compile dosimetric data for planning target volume (PTV) and OARs 2. Segment GTV on fractional scan for radiomics analysis and evaluate response to treatment 3. Compare predicted, re-optimized and delivered dose using ViewRay treatment planning system (TPS) and document statistical significance 4. Determine overall survival, progression free survival and local control from the attending care provider assessments 5. Assess toxicity in the series of patients treated on ViewRay delivered 15 or 5 fractions | This study involves working with a team of radiation oncologists and physicists. It is a retrospective review of dosimetric and clinical outcomes of liver patients treated with maximum inhale breath hold on ViewRay. Students, depending upon their interest and skill sets, will have opportunity to work on any of the four steps described above. In particular the student participant in the study will work with a multidisciplinary group of staff and faculty to compile and analyze the clinical data for liver patients treated with MRI guided radiation treatments and contribute to the preparation of a publishable document (abstract, poster, article). | Interested in Radiation oncology, imaging and Radiation therapy planning | In place | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | 1) Predicting tumour motion during the whole radiotherapy treatment: a systematic approach for thoracic and abdominal lesions based on real time MR. 2) Feasibility of magnetic resonance imaging-guided liver stereotactic body radiation therapy: A comparison between modulated tri-cobalt-60 teletherapy and linear accelerator-based intensity modulated radiation therapy. 3) A clinical-radiomic model for improved prognostication of surgical candidates with colorectal liver metastases. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufxpK1gVxag0dnU6IioeRDkogsWmyFAYqF_tiMPUZfEk-FRsqfXWKL-lrBxahTdWF4 | |||||
| 26/12/2019 | Radiology | Research Electives for credit | Impact of CT Perfusion on Stroke Patient Disposition: Large Vessel Occlusion: Review all strokes scanned at a community hospital site and identify patients with emergent large vessel occlusion and with CT-perfusion imaging available. Record the appropriate data (infarct core, penumbra, mismatch, hypoperfusion index) and determine if / how patient disposition was affected; specifically, if patients were transferred to the comprehensive stroke center for thombectomy or if patients were determined not to be candidates for therapy. As a derivative of this data, the costs of software subscription for perfusion processing versus the revenue from retained stroke admissions could be analyzed and likely support justification of the expense in primary stroke centers. ____________________________________________________________________________ Role - Chart review, data aggregation, manuscript writing and editing; IRB Status - N/A; Skills - Excel worksheets | 0 | agrayev@uwhealth.org | Allison | Grayev | MD | Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner, MD akuner@uwhealth.org | Associate Professor | 6.082.627.854 | Neuroradiology | Anthony Kuner, MD | akuner@uwhealth.org | Radiology | Impact of CT Perfusion on Stroke Patient Disposition: Large Vessel Occlusion | Review all strokes scanned at a community hospital site and identify patients with emergent large vessel occlusion and with CT-perfusion imaging available. Record the appropriate data (infarct core, penumbra, mismatch, hypoperfusion index) and determine if / how patient disposition was affected; specifically, if patients were transferred to the comprehensive stroke center for thombectomy or if patients were determined not to be candidates for therapy. As a derivative of this data, the costs of software subscription for perfusion processing versus the revenue from retained stroke admissions could be analyzed and likely support justification of the expense in primary stroke centers. | Chart review, data aggregation, manuscript writing and editing | Excel worksheets | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Stroke Imaging and Protocols – Best Practices A Kuner and A Grayev, American Roentgen Ray Society 2019 Categorical Course Syllabus | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufAbAdtx4ukn_DiHG6wqDaKbmzTxr4awroseN_C-JBbxRoTaOkNpgGlGtSuJsCbU0M | ||||
| 26/12/2019 | Radiology | Research Electives for credit | 2. Transforaminal Approach for Intrathecal Access: Safety Profile : Review project including a literature search aggregating all available papers on to review the volumes of the procedure performed and create a safety profile based on grouping the single center experience on the safety and efficacy of transforaminal lumbar puncture in the setting of spinal muscular atrophy for the intrathecal administration of nusinersen. This has the potential to establish standard of care for these patients, particularly following spinal fusion. ____________________________________________________________________________ Role - Literature review, data aggregation, manuscript writing / editing; IRB Status - N/A; Skills - Excel worksheet | 0 | agrayev@uwhealth.org | Allison | Grayev | MD | Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner, MD akuner@uwhealth.org | Associate Professor | 6.082.627.854 | Anthony Kuner, MD | akuner@uwhealth.org | Radiology | 2. Transforaminal Approach for Intrathecal Access: Safety Profile | Review project including a literature search aggregating all available papers on to review the volumes of the procedure performed and create a safety profile based on grouping the single center experience on the safety and efficacy of transforaminal lumbar puncture in the setting of spinal muscular atrophy for the intrathecal administration of nusinersen. This has the potential to establish standard of care for these patients, particularly following spinal fusion. | Literature review, data aggregation, manuscript writing / editing | Excel worksheet | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | None published at UW - Shokuhfar T et al "Transforaminal Intrathecal Access for Injection of Nusinersen in Adult and Pediatric Patients with Spinal Muscular Atrophy" J Pediatr Neurol 2018 Nascene et al "Transforaminal Lumbar Puncture: An Alternative Technique in Patients with Challenging Access" AJNR 2018 Jacobson JP et al "Simple Fluoroscopy-Guided Transforaminal Lumbar Puncture: Safety and Effectiveness of a Coaxial Curved-Needle Technique in Patients with Spinal Muscular Atrophy and Complex Spines" AJNR 2019 | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudhG9YCNFx6vVU7vVHiDAY4vV5c8ClbZDb1B9nrR9VG6-E2MEyL2I9b3OxOmEIMWwI | |||||
| 26/12/2019 | Radiology | Research Electives for credit | 3. Impact of Procedural Lumbar Puncture Service on Radiology Lumbar Puncture Volumes : Review the patients referred for fluoroscopic guided lumbar punctures (LP) and examine patient factors (height, weight, BMI, admission unit, needle type, length, etc.) of patients undergoing LP and assess which patients ultimately require image-guided lumbar puncture. Assess the impact on overall procedure volume both within the hospital as well as the effect on the number of image-guided lumbar punctures. ____________________________________________________________________________ Role - Chart review, data aggregation, manuscript writing / editing; IRB Status - N/A; Skills - Excel | 0 | agrayev@uwhealth.org | Allison | Grayev | MD | Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner, MD akuner@uwhealth.org | Associate Professor | 6.082.627.854 | Anthony Kuner, MD | akuner@uwhealth.org | Radiology | 3. Impact of Procedural Lumbar Puncture Service on Radiology Lumbar Puncture Volumes | Review the patients referred for fluoroscopic guided lumbar punctures (LP) and examine patient factors (height, weight, BMI, admission unit, needle type, length, etc.) of patients undergoing LP and assess which patients ultimately require image-guided lumbar puncture. Assess the impact on overall procedure volume both within the hospital as well as the effect on the number of image-guided lumbar punctures. | Chart review, data aggregation, manuscript writing / editing | Excel | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | None at UW - Kroll H et al "Trends in Lumbar Puncture Over 2 Decades: A Dramatic Shift to Radiology" AJR 2015 Read More: https://www.ajronline.org/doi/full/10.2214/AJR.14.12622 Nayate AP "Using Body Mass Index to Predict Needle Length in Fluoroscopy-Guided Lumbar Punctures" AJNR 2016 Hudgins PA et al "Difficult Lumbar Puncture: Pitfalls and Tips from the Trenches" AJNR 2017 | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueZ4NXDu3tEPafRUOrD22Vedym0ffCLGJscpo7d3q595HJoQQVNODCB-PNq-G-7y3c | |||||
| 26/12/2019 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Autoantibodies in Rheumatologic Disease: A major research focus in my laboratory is using traditional methodology and cutting-edge high density array technology with innovative statistical methods to discover new autoantibody targets as well as novel features of antibody and autoantibody reactivity in rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases. By doing so, we learn about disease pathophysiology and lay the groundwork for optimal clinical tests. There are several research projects that fit under this umbrella looking at antibodies and autoantibodies in a variety rheumatic diseases available for a summer project. ____________________________________________________________________________ Role - The student will: 1. Learn about the research area and experimental techniques. 2. Accurately perform experiments (ELISA and others). 3. Keep detailed notes. 4. Carefully analyze experimental results using Excel and basic statistical methods. 5. Contribute to the direction of the project. 6. Discuss results weekly with Dr. Shelef. 7. Work as a team with other members of the Shelef lab. 8. Present results at the end of the summer.; IRB Status - Approved.; Skills - At least one year of previous research experience at the bench. | 1 | mshelef@medicine.wisc.edu | Miriam | Shelef | MD, PhD | Miriam Shelef, mshelef@medicine.wisc.edu -- Co-Mentor: | Assistant Professor | Rheumatology | Autoantibodies in Rheumatologic Disease | A major research focus in my laboratory is using traditional methodology and cutting-edge high density array technology with innovative statistical methods to discover new autoantibody targets as well as novel features of antibody and autoantibody reactivity in rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases. By doing so, we learn about disease pathophysiology and lay the groundwork for optimal clinical tests. There are several research projects that fit under this umbrella looking at antibodies and autoantibodies in a variety rheumatic diseases available for a summer project. | The student will: 1. Learn about the research area and experimental techniques. 2. Accurately perform experiments (ELISA and others). 3. Keep detailed notes. 4. Carefully analyze experimental results using Excel and basic statistical methods. 5. Contribute to the direction of the project. 6. Discuss results weekly with Dr. Shelef. 7. Work as a team with other members of the Shelef lab. 8. Present results at the end of the summer. | After learning skills, experiments should be performed independently. | At least one year of previous research experience at the bench. | Approved. | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Disordered Antigens and Epitope Overlap Between Anti-Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis. Zheng Z, Mergaert AM, Fahmy LM, Bawadekar M, Holmes CL, Ong IM, Bridges AJ, Newton MA, Shelef MA. Arthritis Rheumatol. 2019 Aug 8. doi: 10.1002/art.41074. [Epub ahead of print] Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans. Mergaert AM, Bawadekar M, Nguyen TQ, Massarenti L, Holmes CL, Rebernick R, Schrodi SJ, Shelef MA. Int J Mol Sci. 2019 Jun 25;20(12). pii: E3093. doi: 10.3390/ijms20123093. Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects. Holmes CL, Peyton CG, Bier AM, Donlon TZ, Osman F, Bartels CM, Shelef MA. PLoS One. 2019 May 28;14(5):e0217221. doi: 10.1371/journal.pone.0217221. eCollection 2019. New Relationships for Old Autoantibodies in Rheumatoid Arthritis. Shelef MA. Arthritis Rheumatol. 2019 Sep;71(9):1396-1399. | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucs86Yp28MFKfJjtg_znys9AYAyrEjyEImJ_uaSnooxjzU73QvyUlmyhnA58SNJl00 | |||||||
| 16/01/2020 | Pediatrics | LEND program provides stipends for long-term trainees during academic year participation | Strengthening Lifespan Care for Individuals with Down Syndrome: Working with members of the Down syndrome community, we propose to develop a survey to identify the strengths and gaps in providing lifespan health care for individuals with Down syndrome. This work will be done in collaboration with the Down syndrome clinic at Waisman Center, the LEND Training program at Waisman Center, and other health professional and community stakeholders. ____________________________________________________________________________ Role - Student will be involved in the development, dissemination, data collection and analysis for the community-based survey of healthcare needs for individuals with Down syndrome.; IRB Status - N/A at this time; Skills - Collaboration, computer skills, some knowledge of healthcare needs for individuals with intellectual and developmental disabilities. | 0 | harris@waisman.wisc.edu | Anne | Harris | PhD, MPH | Anne Harris, harris@waisman.wisc.edu -- Co-Mentor: Maria Stanley maria.stanley@wisc.edu | Clinical Professor | 608 | Develomental Pediatrics | Other | Waisman Center | Maria Stanley | maria.stanley@wisc.edu | Pediatrics | Developmental/Behavioral Pediatrics | Strengthening Lifespan Care for Individuals with Down Syndrome | Working with members of the Down syndrome community, we propose to develop a survey to identify the strengths and gaps in providing lifespan health care for individuals with Down syndrome. This work will be done in collaboration with the Down syndrome clinic at Waisman Center, the LEND Training program at Waisman Center, and other health professional and community stakeholders. | Student will be involved in the development, dissemination, data collection and analysis for the community-based survey of healthcare needs for individuals with Down syndrome. | Moderate - student will need to collaborate with stakeholders and faculty mentor, but will be completing some tasks on their own. | Collaboration, computer skills, some knowledge of healthcare needs for individuals with intellectual and developmental disabilities. | N/A at this time | Faculty mentor(s) supported by the LEND training program grant (federally funded by HRSA/MCHB). | possibly/not sure - need to check the training grant funding requirements/restrictions | Yes | DPT students, Genetic Counseling students, MPH students, PhD students | no manuscripts - we have applied for funding for this project from several sources | Yes | Kimberly Kile, LEND Program Coordinator | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueg1BdYjGa-R-ibztNgoslC_TJC85y4Mh9TmqiJZ8dVOEJ7xnQKcVmeSlP8w3DDBnU |
| 27/12/2019 | Radiology | Not currently interested or available for Non-Shapiro research mentoring of medical students | BI-RADS 4A Calcifications: Radiologist Accuracy in Determining Risk for Breast Cancer: Calcifications are commonly present on digital mammography and can be associated with both benign and malignant processes. Evaluation of suspicious calcifications is completed with spot compression views during diagnostic mammography evaluation. Specific descriptors are utilized to assess calcifications which thensubsequently guide management. Based on current BIRADS classification guidelines, suspicious calcifications may be classified as 4B (moderate suspicion) or 4C (high suspicion). However, there is question as to whether or not calcifications can be appropriately subcategorized as BIRADS 4A (low suspicion) based on specific characteristics. This study is designed to assess the postive predictive value for calcifications that are determined to be of low suspicion during diagnostic mammogram examination. ____________________________________________________________________________ Role - Data collection, data analysis, and manuscript preparation; IRB Status - Approved under Radiology Retrospective Study IRB; Skills - None specific. | 1 | rwoods@uwhealth.org | Ryan | Woods | MD, MPH | Ryan Woods, rwoods@uwhealth.org -- Co-Mentor: | Assistant Professor of Radiology | 6.082.639.377 | Breast Imaging | BI-RADS 4A Calcifications: Radiologist Accuracy in Determining Risk for Breast Cancer | Calcifications are commonly present on digital mammography and can be associated with both benign and malignant processes. Evaluation of suspicious calcifications is completed with spot compression views during diagnostic mammography evaluation. Specific descriptors are utilized to assess calcifications which thensubsequently guide management. Based on current BIRADS classification guidelines, suspicious calcifications may be classified as 4B (moderate suspicion) or 4C (high suspicion). However, there is question as to whether or not calcifications can be appropriately subcategorized as BIRADS 4A (low suspicion) based on specific characteristics. This study is designed to assess the postive predictive value for calcifications that are determined to be of low suspicion during diagnostic mammogram examination. | Data collection, data analysis, and manuscript preparation | Moderate | None specific. | Approved under Radiology Retrospective Study IRB | No | No (plan to use Dean's Office Funds) | Yes | MPH students | Please see https://paperpile.com/shared/42JkfI | No | Lorene Seman | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucC-M2bF8c-DwOnPxWvnZthCLfokwEL_6aLejMp9yLQJi7vRY9giTm5gByX3Ck9E0c | ||||||
| 29/12/2019 | Orthopedics and Rehabilitation | Shorter term projects | Effect of Pain Plan Implementation in Orthopedic Surgery: In May 2019, we implemented a Pain Plan for all patients undergoing elective spine surgery. The Pain Plan consists of a pre-operative discussion with the patient that stratifies them based on narcotic history, then lays out a specific individualized Pain Plan for each patient. The goal is to improve the patient’s peri-operative pain management, decrease narcotic use, and decrease the number of phone calls to the clinic for pain management issues. Preliminary indications are that this Pain Plan is having a very positive effect. We are going to compare the several hundred patients who had a pain plan (since May 2019) to several hundred patients who did not have a pain plan (prior to May 2019), and assess the effect on post-operative narcotic usage and phone calls to clinic. With the current opioid epidemic, narcotic use after surgery has become a very hot topic, and this is unchartered territory in orthopedic surgery. We have a large data set and will be able to publish meaningful research and present at national meetings, we are on the forefront of this movement. We built a database in REDCap, and the student will participate in maintaining this database. They will review charts and enter data into the database, analyze the data, interface with the statistician, do literature searches, and prepare manuscripts and abstracts. We expect that the project will be completed by the end of the summer, but there will be ongoing analysis as we roll the pain plan out to other orthopedic surgery divisions, so future opportunities may be available as well. If the student is interested, they will have the opportunity to shadow in clinic and in the OR, to interact with orthopedic surgery faculty, fellows, and residents (likely a resident or two will be involved in the project), and learn more about what it is like to be an orthopedic surgeon. ____________________________________________________________________________ Role - Chart review, data collection, data entry and data analysis, literature search, manuscript preparation, abstract preparation and submission to national meetings. ; IRB Status - QI IRB approved, Research IRB submitted; Skills - Excel and Word | 0 | swilliams@ortho.wisc.edu | Seth | Williams | MD | Seth Williams, swilliams@ortho.wisc.edu -- Co-Mentor: Miranda Bice, MD bice@ortho.wisc.edu | Associate Professor, Clinical Vice Chair, Orthopedic Surgery | 0 | Spine Surgery | Miranda Bice, MD | bice@ortho.wisc.edu | Orthopedics and Rehabilitation | Spine Surgery | Effect of Pain Plan Implementation in Orthopedic Surgery | In May 2019, we implemented a Pain Plan for all patients undergoing elective spine surgery. The Pain Plan consists of a pre-operative discussion with the patient that stratifies them based on narcotic history, then lays out a specific individualized Pain Plan for each patient. The goal is to improve the patient’s peri-operative pain management, decrease narcotic use, and decrease the number of phone calls to the clinic for pain management issues. Preliminary indications are that this Pain Plan is having a very positive effect. We are going to compare the several hundred patients who had a pain plan (since May 2019) to several hundred patients who did not have a pain plan (prior to May 2019), and assess the effect on post-operative narcotic usage and phone calls to clinic. With the current opioid epidemic, narcotic use after surgery has become a very hot topic, and this is unchartered territory in orthopedic surgery. We have a large data set and will be able to publish meaningful research and present at national meetings, we are on the forefront of this movement. We built a database in REDCap, and the student will participate in maintaining this database. They will review charts and enter data into the database, analyze the data, interface with the statistician, do literature searches, and prepare manuscripts and abstracts. We expect that the project will be completed by the end of the summer, but there will be ongoing analysis as we roll the pain plan out to other orthopedic surgery divisions, so future opportunities may be available as well. If the student is interested, they will have the opportunity to shadow in clinic and in the OR, to interact with orthopedic surgery faculty, fellows, and residents (likely a resident or two will be involved in the project), and learn more about what it is like to be an orthopedic surgeon. | Chart review, data collection, data entry and data analysis, literature search, manuscript preparation, abstract preparation and submission to national meetings. | Moderate - Direction will be provided, and we will regularly meet and collaborate, but the student will need to be self-motivated to complete the project by the end of the summer program. | Excel and Word | QI IRB approved, Research IRB submitted | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | None - this is unchartered territory! | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuewsONjYpwNIL69iZ8znrU2oZA4o5GmXqnYPQY0XeDCjZ6kljzTZ4mHa4E087w0Md0 | ||
| 29/12/2019 | Human Oncology | Shorter term projects, Research Electives for credit | Prognostic significance of imaging characteristics and radiation dose and fractionation in the treatment of prostate cancer: BACKGROUND: In the last several years there has been a dramatic increase in the use of advanced imaging modalities in the initial evaluation and staging of prostate cancer, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI). These imaging modalities allow us to identify areas of cancer with far more accuracy, both within the prostate as well as in the rest of the body, and they therefore have the potential to dramatically change how we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative and semi-quantitative metrics can be derived from these images. If these imaging metrics are prognostic of outcomes for patients with prostate cancer, this may help guide treatment decisions (e.g. use of radiation therapy, radiation dose, use of androgen deprivation therapy, duration of androgen deprivation therapy). Examination of how these imaging modalities have impacted treatment decisions to date, and if imaging metrics derived from them are prognostic of outcomes, would help guide future prospective studies using these imaging modalities to guide personalized therapy. One way advanced imaging modalities may impact radiation therapy is in selection of radiation dose and fractionation. A number of studies have investigated the effects of total radiation dose and dose per fraction on outcomes and toxicities in prostate cancer. The overall conclusions from these studies can essentially be summarized as: 1) Increased radiation dose improves disease control, at the cost of slightly worse toxicity, and 2) When only the prostate is treated, higher radiation doses per fraction (hypofractionation) can be used while maintaining disease outcomes and without worsening toxicities. For the last several years, a number of patients have been treated at the University of Wisconsin trying to escalate dose to specific areas of the target volume (for example lesions seen on MRI) while maintaining strict constraints on surrounding organs. In addition, over the last several years a number of different dose and fractionation schemes have been utilized in the treatment of prostate cancer. Studying disease outcomes and toxicities associated with these approaches would help identify clinical questions that should be further studied prospectively. SPECIFIC AIMS: 1. Determine if radiation dose and fractionation (e.g. hypofractionation, dose escalation) impact disease outcomes (e.g. biochemical disease free survival, distant-metastasis free survival, overall survival) in patients with prostate cancer treated with radiation therapy. 2. Identify pre-treatment imaging characteristics from positron emission tomography (PET), computed tomography (CT), and magnetic resonance imagine (MRI) that are prognostic for outcomes for patients with prostate cancer treated with radiation therapy. 3. Determine if radiation dose and fractionation and/or imaging characteristics are associated with acute and late toxicities. PROCEDURES: This study is a retrospective review of information pertaining to the diagnosis, treatment, toxicity, and outcomes of patients diagnosed with prostate cancer and treated with radiation therapy at the University of Wisconsin from 1/1/2007- 10/31/2019. Individual patient records will be reviewed to identify various patient, treatment, disease, and toxicity outcomes. We will use the hospital's medical record system to obtain patient clinical and treatment characteristics, overall survival, disease free survival, distant metastasis free survival, and cancer specific survival. We will also assess the toxicities associated with treatment. Records to be reviewed include consult notes, progress notes, procedure notes, imaging studies, and pathology reports. In addition to review of medical records, we will also review clinical images (e.g. PET/CT and MRI scans) obtained as part of routine clinical care. These images will be analyzed in our departmental software used for routine clinical care (MIM). De-identified images will also be analyzed using commercially available software (e.g. Matlab) to perform analysis that cannot be carried out in MIM. Descriptive statistics, parametric tests (e.g. Student’s t-test), and non-parametric tests (e.g. Fisher’s exact, Mann-Whitney U test) will be used to compare different groups of patients. Survival analysis will be performed using standard methods (Kaplan-meier, log-rank, Cox regression) to evaluate the prognostic significance of different radiation dose/fractionation schemes, and imaging based markers. Cumulative incidence, logistic regression, and other regression analyses will be used to evaluate time to toxicities and hazard ratios for toxicities for patients treated with different dose/fractionation schemes, and for patients grouped by different imaging characteristics. ____________________________________________________________________________ Role - -Review patient charts for relevant clinical and treatment information -Updating and maintaining a database including this information -Reviewing and analyzing diagnostic images (PET, MRI, and CT) and extracting quantitative metrics from these images. This can be done on software available through the Department of Human Oncology and Department of Radiology, but could also include analysis with programs written and developed by students. -Performing statistical analysis of the data collected. -Writing up and presenting results from the project.; IRB Status - Approved; Skills - Familiarity with image analysis and some programming (Python, Matlab), as well as some experience with statistical analysis would be helpful but are not required. | 0 | jfloberg@humonc.wisc.edu | John | Floberg | MD, PhD | John Floberg, jfloberg@humonc.wisc.edu -- Co-Mentor: | Assistant Professor (CHS) | 0 | Prognostic significance of imaging characteristics and radiation dose and fractionation in the treatment of prostate cancer | BACKGROUND: In the last several years there has been a dramatic increase in the use of advanced imaging modalities in the initial evaluation and staging of prostate cancer, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI). These imaging modalities allow us to identify areas of cancer with far more accuracy, both within the prostate as well as in the rest of the body, and they therefore have the potential to dramatically change how we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative and semi-quantitative metrics can be derived from these images. If these imaging metrics are prognostic of outcomes for patients with prostate cancer, this may help guide treatment decisions (e.g. use of radiation therapy, radiation dose, use of androgen deprivation therapy, duration of androgen deprivation therapy). Examination of how these imaging modalities have impacted treatment decisions to date, and if imaging metrics derived from them are prognostic of outcomes, would help guide future prospective studies using these imaging modalities to guide personalized therapy. One way advanced imaging modalities may impact radiation therapy is in selection of radiation dose and fractionation. A number of studies have investigated the effects of total radiation dose and dose per fraction on outcomes and toxicities in prostate cancer. The overall conclusions from these studies can essentially be summarized as: 1) Increased radiation dose improves disease control, at the cost of slightly worse toxicity, and 2) When only the prostate is treated, higher radiation doses per fraction (hypofractionation) can be used while maintaining disease outcomes and without worsening toxicities. For the last several years, a number of patients have been treated at the University of Wisconsin trying to escalate dose to specific areas of the target volume (for example lesions seen on MRI) while maintaining strict constraints on surrounding organs. In addition, over the last several years a number of different dose and fractionation schemes have been utilized in the treatment of prostate cancer. Studying disease outcomes and toxicities associated with these approaches would help identify clinical questions that should be further studied prospectively. SPECIFIC AIMS: 1. Determine if radiation dose and fractionation (e.g. hypofractionation, dose escalation) impact disease outcomes (e.g. biochemical disease free survival, distant-metastasis free survival, overall survival) in patients with prostate cancer treated with radiation therapy. 2. Identify pre-treatment imaging characteristics from positron emission tomography (PET), computed tomography (CT), and magnetic resonance imagine (MRI) that are prognostic for outcomes for patients with prostate cancer treated with radiation therapy. 3. Determine if radiation dose and fractionation and/or imaging characteristics are associated with acute and late toxicities. PROCEDURES: This study is a retrospective review of information pertaining to the diagnosis, treatment, toxicity, and outcomes of patients diagnosed with prostate cancer and treated with radiation therapy at the University of Wisconsin from 1/1/2007- 10/31/2019. Individual patient records will be reviewed to identify various patient, treatment, disease, and toxicity outcomes. We will use the hospital's medical record system to obtain patient clinical and treatment characteristics, overall survival, disease free survival, distant metastasis free survival, and cancer specific survival. We will also assess the toxicities associated with treatment. Records to be reviewed include consult notes, progress notes, procedure notes, imaging studies, and pathology reports. In addition to review of medical records, we will also review clinical images (e.g. PET/CT and MRI scans) obtained as part of routine clinical care. These images will be analyzed in our departmental software used for routine clinical care (MIM). De-identified images will also be analyzed using commercially available software (e.g. Matlab) to perform analysis that cannot be carried out in MIM. Descriptive statistics, parametric tests (e.g. Student’s t-test), and non-parametric tests (e.g. Fisher’s exact, Mann-Whitney U test) will be used to compare different groups of patients. Survival analysis will be performed using standard methods (Kaplan-meier, log-rank, Cox regression) to evaluate the prognostic significance of different radiation dose/fractionation schemes, and imaging based markers. Cumulative incidence, logistic regression, and other regression analyses will be used to evaluate time to toxicities and hazard ratios for toxicities for patients treated with different dose/fractionation schemes, and for patients grouped by different imaging characteristics. | -Review patient charts for relevant clinical and treatment information -Updating and maintaining a database including this information -Reviewing and analyzing diagnostic images (PET, MRI, and CT) and extracting quantitative metrics from these images. This can be done on software available through the Department of Human Oncology and Department of Radiology, but could also include analysis with programs written and developed by students. -Performing statistical analysis of the data collected. -Writing up and presenting results from the project. | Students will be free to develop a specific project that best fits their interests and background within the broad aims outlined above. If needed, students can be provided with some instruction in image analysis and statistical analysis. | Familiarity with image analysis and some programming (Python, Matlab), as well as some experience with statistical analysis would be helpful but are not required. | Approved | No | Yes | Yes | PhD students, UW undergraduates interested in research | -Maurer, et al. Diagnostic efficacy of (68)gallium-PSMA positron emission tomography compared to conventional imaging for lymph node staging of 130 consecutive patients with intermediate and high risk prostate cancer. J Urol. 2016 May;195(5):1436-1443. -Calais J, et al. Impact of (68)Ga-PSMA-11 PET/CT on the management of prostate cancer patients with biochemical recurrence. JNM. 2018 March;59(3):434-441. -Koerber S, et al. (68)Ga-PSMA-11 PET/CT in primary and recurrent prostate carcinoma: implications for radiotherapeutic management in 121 patients. JNM. 2019 Feb;60(2):234-240. -Schreibmann E, et al. Image guided planning for prostate carcinomas with incorporation of anti-3-[18F]FACBC (fluciclovine) positron emission tomography: workflow and initial findings from a randomized trial. Int J Radiat Oncol Biol Phys. 2016;96(1):206-213. -Brower JV, et al. Quality of life outcomes from a dose-per-fraction escalation trial of hypo fractionation in prostate cancer. Radiother Oncol. 2016 Jan; 118(1):99-104. -Adkinson JB, et al. Phase I trial of pelvic nodal dose escalation with hypofractionated IMRT for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):184-90. | No | Ranee Williams-Toycen, williams@humonc.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf7nWVQIZ0nChrJYfExBsRpSyyVZZxAph7Wl0PHKhR-nqPj1MhhVXJv_jDwKvhXrzw | |||||||
| 29/12/2019 | Human Oncology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Utilizing genomics and radiomics to understand the outcome of patients with non-small cell lung cancer brain metastases.: This project will involve analyzing genomic, radiomic and clinical data from a cohort of patients with non-small cell lung cancer brain metastases. ____________________________________________________________________________ Role - Assist in data analysis.; IRB Status - approved; Skills - basic data analysis skills. Bioinformatics and programming skills would be valuable but not required. | 1 | baschnagel@humonc.wisc.edu | Andrew | Baschnagel | M.D. | Andrew Baschnagel, baschnagel@humonc.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Utilizing genomics and radiomics to understand the outcome of patients with non-small cell lung cancer brain metastases. | This project will involve analyzing genomic, radiomic and clinical data from a cohort of patients with non-small cell lung cancer brain metastases. | Assist in data analysis. | basic data analysis skills. Bioinformatics and programming skills would be valuable but not required. | approved | No | No (plan to use Dean's Office Funds) | Yes | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Development and characterization of patient derived xenografts from non-small cell lung cancer brain metastases. | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueRIS9OKpEr_uhm4dUT7nIIlE62UjQQDKdj1tacEwNv04NzedfSCafpEcF3fzypnHo | ||||||||
| 30/12/2019 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Acute Myocardial Retention of Cardio-Therapeutic Cells following Myocardial Infarction: Stem cell therapy for cardiac repair has emerged as an exciting, potentially revolutionary treatment for heart disease. One limitation in the field is how to keep the cells from egressing rapidly out of the myocardium following local injection. Our laboratory is testing novel delivery approaches to improve acute cell retention to optimize the local effective cell dose and augment the therapeutic efficacy of the cells. The Shapiro summer students would take on a discrete project, where quantum dot and radio-labeled cells are injected into infarcted myocardium, in a porcine model, and imaged using cryo-imaging and CT-PET at pre-defined intervals thereafter. The cells would be co-administered with a novel cardiac fibroblast derived cell retention matrix. Quantitative analysis for cell retention and geographic distribution will be made. The hypothesis is that the cell retention matrix will significantly boost acute and mid term cell retention compared to injecting the cells alone. ____________________________________________________________________________ Role - To learn how to label cells, to have the cell product available to the veterinary surgical team for administration, to measure cell retention using cryo-imaging and CT-PET and understand the principals associated with those imaging methods, and to submit their data for abstract presentation at the American College of Cardiology Conference 2021. ; IRB Status - N/A; Skills - Basic understanding of cardiac anatomy, and being able to work well with others is all that is required. | 2 | anr@medicine.wisc.edu | Amish | Raval | MD | Amish Raval, anr@medicine.wisc.edu -- Co-Mentor: Eric Schmuck PhD egs@medicine.wisc.edu | Associate Professor of Medicine, Director of Clinical Cardiovascular Research | 6.082.630.836 | Cardiovascular Medicine | Eric Schmuck PhD | egs@medicine.wisc.edu | Medicine | Cardiovascular Medicine | Acute Myocardial Retention of Cardio-Therapeutic Cells following Myocardial Infarction | Stem cell therapy for cardiac repair has emerged as an exciting, potentially revolutionary treatment for heart disease. One limitation in the field is how to keep the cells from egressing rapidly out of the myocardium following local injection. Our laboratory is testing novel delivery approaches to improve acute cell retention to optimize the local effective cell dose and augment the therapeutic efficacy of the cells. The Shapiro summer students would take on a discrete project, where quantum dot and radio-labeled cells are injected into infarcted myocardium, in a porcine model, and imaged using cryo-imaging and CT-PET at pre-defined intervals thereafter. The cells would be co-administered with a novel cardiac fibroblast derived cell retention matrix. Quantitative analysis for cell retention and geographic distribution will be made. The hypothesis is that the cell retention matrix will significantly boost acute and mid term cell retention compared to injecting the cells alone. | To learn how to label cells, to have the cell product available to the veterinary surgical team for administration, to measure cell retention using cryo-imaging and CT-PET and understand the principals associated with those imaging methods, and to submit their data for abstract presentation at the American College of Cardiology Conference 2021. | Students will be expected to be self-motivated and driven to learn about new laboratory techniques, the fundamental principles of cardiac imaging, and work closely and collaboratively with the Raval Lab. | Basic understanding of cardiac anatomy, and being able to work well with others is all that is required. | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Raval AN, Cook TD, Duckers H, Johnston PV, Traverse JH, Abraham WT, Altman PA, Pepine CJ. The CardiAMP Heart Failure trial: A Randomized Controlled Pivotal Trial of High Dose Autologous Bone Marrow Mononuclear Cells Using the CardiAMP Cell Therapy System in Patients with Post Myocardial Infarction Heart Failure: Trial Rationale and Study Design. American Heart Journal 2018;201;141-148. Zhang J, Tao R, Campbell KF Carvalho JL, Ruiz EC, Kim GC, Schmuck EG, Raval AN, Roche A, Herron TJ, Jalife J, Thomson JA, Kamp TJ. Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors. Nature Communications 2019 May 20;10(1):2238. PMC6527555 Alexanian RA, Mahapatra K, Lang D, Vaidyanathan R, Markandeya YS, Gill RK, Zhai AJ, Dhillon A, Lea MR, Abozeid S, Schmuck EG, Raval AN, Eckhardt LL, Glukhov AV, Lalit PA, Kamp TJ. Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue. Biochim Biophys Acta Mol Cell Res. 2019 Oct 18:118559. PMID: 31634503 Schmuck EG, Koch JM, Centanni JM, Hacker TA, Braun RK, Eldridge M, Hei DJ, Hematti P, Raval AN. Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model. Stem Cells Transl Med 2016: July 26 PMID 27460855, PMC5189648 Schmuck EG, Koch JM, Hacker TA, Hatt CR, Tomkowiak MT, Vigen KK, Hendren N, Leitzke C, Zhao YQ, Li Z, Centanni JM, Hei DJ, Schwahn D, Kim J, Hematti P, Raval AN. Intravenous Followed by X-ray Fused with MRI-Guided Transendocardial Mesenchymal Stem Cell Injection Improves Contractility Reserve in a Swine Model of Myocardial Infarction. J Cardiovasc Transl Res. 2015 Oct;8(7):438-48. PMC5006679 Raval AN, Schmuck EG, Tefera G, Leitzke C, Ark CV, Hei D, Centanni JM, de Silva R, Koch J, Chappell RG, Hematti P. Bilateral administration of autologous CD133+ cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blind, placebo-controlled trial. Cytotherapy. 2014 Dec;16(12):1720-32. PMID 25239491 | Yes | Eric Schmuck PhD, egs@medicine.wisc.edu Sushmita Roy PhD, sroy@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufQZpzWmbuDtBulgQZsjy4v460U7lbaQ2FxHSZgRKM1ILJleySTmqQzuVZ_Ildn_5Y | ||
| 04/02/2020 | Radiology | Shorter term projects | Rapid MRI for occult osteoporotic fractures of the hip: Osteoporotic fractures of the hip in elderly patients result in a substantial public health burden in the US and around the world. Although the majority of fractures are diagnosed with x-rays, a substantial percentage will be radiographically occult. Rapid diagnosis of these fractures with advanced imaging has been shown to improve patient outcomes. The gold standard for diagnosis is MRI but long scanning times have limited its use in this elderly population. We have developed and refined a rapid MRI protocol with scan time of less than 5 minutes for use in this clinical scenario. Our initial study showed promising results and we have further improved the protocol since that time. This study will be a retrospective chart review comparing the accuracy of rapid MRI against the gold standard of clinical follow up. The interested student will participate in analysis planning, chart review, and abstract and manuscript preparation, all with careful faculty mentoring. This will be an opportunity to learn fundamentals of research technique in conjunction with producing practical research on an important public health topic. ____________________________________________________________________________ Role - Chart review, analysis planning, abstract and manuscript preparation; IRB Status - Approved; Skills - No specific skills required. | 0 | aross@uwhealth.org | Andrew | Ross | MD MPH | Andrew Ross, aross@uwhealth.org -- Co-Mentor: | Dr. | Musculoskeletal Imaging and Intervention | Rapid MRI for occult osteoporotic fractures of the hip | Osteoporotic fractures of the hip in elderly patients result in a substantial public health burden in the US and around the world. Although the majority of fractures are diagnosed with x-rays, a substantial percentage will be radiographically occult. Rapid diagnosis of these fractures with advanced imaging has been shown to improve patient outcomes. The gold standard for diagnosis is MRI but long scanning times have limited its use in this elderly population. We have developed and refined a rapid MRI protocol with scan time of less than 5 minutes for use in this clinical scenario. Our initial study showed promising results and we have further improved the protocol since that time. This study will be a retrospective chart review comparing the accuracy of rapid MRI against the gold standard of clinical follow up. The interested student will participate in analysis planning, chart review, and abstract and manuscript preparation, all with careful faculty mentoring. This will be an opportunity to learn fundamentals of research technique in conjunction with producing practical research on an important public health topic. | Chart review, analysis planning, abstract and manuscript preparation | Moderate. | No specific skills required. | Approved | No | No (plan to use Dean's Office Funds) | Yes | MPH students | Ross AB, Chan BY, Yi PH, Repplinger MD, Vanness DJ, Lee KS. Diagnostic Accuracy of an Abbreviated MRI Protocol for Detecting Radiographically Occult Hip and Pelvis Fractures in the Elderly. Skeletal Radiology. 2018 Jun 18; PMID: 29915937. Ross AB, Chan B, Yi P, Repplinger M, Vanness D, Lee KS. Rapid Hip MRI: Feasibility of Detecting Radiographically Occult Hip Fractures in the Elderly. Society of Skeletal Radiology Annual Meeting. Santa Barbara, CA. March 19, 2017. | No | Melissa Kuester | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudsXo1xpT1ZVjldJz02EzdGUEJIOpGOGTQ61Mht1oHJaH77K1x7drVlmJMUj9QSd8M | |||||||
| 12/02/2020 | Radiology | Shorter term projects | A Multidisciplinary Approach to Improving Secondary Fracture Prevention after Vertebroplasty: Osteoporotic fractures of the spine are a common and painful injury of the elderly. For those fractures that fail to heal with conservative management, vertebroplasty is an effective treatment to reduce pain. The occurrence of a secondary fracture after vertebroplasty is up to 10% or higher over two years but this can be substantially reduced if the patient is placed on appropriate bone density treatment. Unfortunately, the majority of patients are not optimized on best-practice bone density treatment following spinal fracture. This project will evaluate the benefit of having a dedicated referral pathway for vertebroplasty patients to a specialist in bone density treatment to have their treatment optimized and managed. The interested student will participate in analysis planning, chart review, and abstract and manuscript preparation, all with careful faculty mentoring. This is an opportunity to learn fundamental research skills while participating in a multi-disciplinary research team with specialists from radiology and orthopedic surgery. The project is expected to produce a national meeting presentation and manuscript submission. ____________________________________________________________________________ Role - analysis planning, chart review, abstract and manuscript preparation; IRB Status - Approved; Skills - No specific skills. | 0 | aross@uwhealth.org | Andrew | Ross | MD MPH | Andrew Ross, aross@uwhealth.org -- Co-Mentor: | Dr. | Musculoskeletal Imaging and Intervention | A Multidisciplinary Approach to Improving Secondary Fracture Prevention after Vertebroplasty | Osteoporotic fractures of the spine are a common and painful injury of the elderly. For those fractures that fail to heal with conservative management, vertebroplasty is an effective treatment to reduce pain. The occurrence of a secondary fracture after vertebroplasty is up to 10% or higher over two years but this can be substantially reduced if the patient is placed on appropriate bone density treatment. Unfortunately, the majority of patients are not optimized on best-practice bone density treatment following spinal fracture. This project will evaluate the benefit of having a dedicated referral pathway for vertebroplasty patients to a specialist in bone density treatment to have their treatment optimized and managed. The interested student will participate in analysis planning, chart review, and abstract and manuscript preparation, all with careful faculty mentoring. This is an opportunity to learn fundamental research skills while participating in a multi-disciplinary research team with specialists from radiology and orthopedic surgery. The project is expected to produce a national meeting presentation and manuscript submission. | analysis planning, chart review, abstract and manuscript preparation | moderate | No specific skills. | Approved | No | No (plan to use Dean's Office Funds) | Yes | MPH students | Gimarc D, Bice M, Hare K, Anderson P, Ross AB. A Multidisciplinary Approach to Improving Secondary Fracture Prevention after Vertebroplasty: Implementing a Fracture Liaison Consultation Service. American College of Radiology Annual Meeting. Washington DC. May 18-22, 2019. Albanese G, Bice M, Anderson PA, Hare K, Ross AB. A Multi-Disciplinary Approach to Improving Secondary Fracture Prevention after Vertebroplasty High Value Practice Academic Alliance Annual Meeting. Baltimore, MD. September 21, 2018. | No | Melissa Kuester | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudjVw4OTfXKsdyPTDxZgD5LjjD5DrfidCCPLrZUWJtELevQ3OhCOtwa2gZw-bY34O4 | |||||||
| 30/12/2019 | Neurological Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | A novel method to isolate circulating tumor cells from biofluids of glioma patients for detection of DNA methylation signatures: Aim 1: Develop a novel method to isolate glioblastoma multiforme (GBM) cells from patient biofluids • Capture 10 to 100 GBM cell line cells spiked into 1,000 peripheral blood mononuclear cells (PBMCs) with 85% average efficiency • Define the detection limit for GBM cells MGMT promoter methylation (me-pMGMT) over PBMCs Aim 2: Test the ability and potential of me-pMGMT evaluation in CTCs from Patients with GBM • To capture CTCs from patients with advanced GBM • To evaluate concordance between solid tumor biopsies and liquid biopsies for me-pMGMT http://www.neurosurgery.wisc.edu/research/alisch ____________________________________________________________________________ Role - Aide in the collection of tumor specimens, DNA extractions, the characterization of the glioblastoma cell lines, and the MGMT promotor methylation status.; IRB Status - Approved 8/12/2019; Skills - Hardworking team player that is self motivated to complete the goals of the project. | 0 | alisch@wisc.edu | Reid | Alisch | PhD | Reid Alisch, alisch@wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.633.793 | A novel method to isolate circulating tumor cells from biofluids of glioma patients for detection of DNA methylation signatures | Aim 1: Develop a novel method to isolate glioblastoma multiforme (GBM) cells from patient biofluids • Capture 10 to 100 GBM cell line cells spiked into 1,000 peripheral blood mononuclear cells (PBMCs) with 85% average efficiency • Define the detection limit for GBM cells MGMT promoter methylation (me-pMGMT) over PBMCs Aim 2: Test the ability and potential of me-pMGMT evaluation in CTCs from Patients with GBM • To capture CTCs from patients with advanced GBM • To evaluate concordance between solid tumor biopsies and liquid biopsies for me-pMGMT http://www.neurosurgery.wisc.edu/research/alisch | Aide in the collection of tumor specimens, DNA extractions, the characterization of the glioblastoma cell lines, and the MGMT promotor methylation status. | Hardworking team player that is self motivated to complete the goals of the project. | Approved 8/12/2019 | Yes | Department of Neurological Surgery has agreed to fund the student's stipend | Yes | MPH students, PhD students, UW undergraduates interested in research | None, this is a new and exciting direction for my lab's research! | Yes | Cassie Whiting | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufEcuOA2P0yBOo33BBUEg2w9dPA5Y8CyfGeMB_zeV6VKibxeLGl0fcEk0in-japq04 | ||||||||
| 30/12/2019 | Other | Not currently interested or available for Non-Shapiro research mentoring of medical students | The Impact of Blood Flush on Post-Reperfusion Syndrome in Liver Transplantation: Hypothesis: Utilization of the blood flush technique in liver transplantation has significantly improved the severity of Post-Reperfusion Syndrome (PRS) and secondary outcomes including intraoperative cardiac arrest and death. This will be a retrospective chart review of the intra-operative hemodynamic changes that occur following reperfusion of the newly transplanted liver and the effects of adopting a practice of caval blood flush vent at the time of reperfusion over the traditional practice. Post-reperfusion syndrome (PRS) is a well-described and defined occurrence in liver transplantation that is associated with abrupt and life-threatening events including: profound hypotension refractory to vasopressors, intracardiac thrombosis, arrhythmias, cardiac arrest, severe acidosis, severe hyperkalemia, abrupt hypothermia and death. By using the blood flush technique via a caval vent, the initial 400 ml of blood effluent through the liver at reperfusion is evacuated rather than entering the systemic circulation. This practice appears to have significantly attenuated these life-threatening occurrences at reperfusion and the severity or PRS. A comparison of the intraoperative incidence and severity of the hemodynamic changes along with secondary outcomes, such as arrhythmia, hyperkalemia, intracardiac thrombosis, vasopressor use, CPR, cardiac arrest and death will be assessed in 400 patients or less who underwent liver transplantation at the University of Wisconsin Hospital before and after the adoption of blood flush technique. The study will be powered to assess for a 25% reduction in PRS ____________________________________________________________________________ Role - The student will be instructed on how to obtain information required from the Healthlink Anesthesia record for the purposes of this study and document the data. The student will be given access to departmental computers that are password protected and will work from our office so that all patient data and information will be protected. If needed the student will undergo HIPAA and other training as required by the University, To aid in the understanding of the process, the student will have an opportunity to shadow me or one of my transplant anesthesia colleagues during a liver transplantation. Once the data is collected, the student will work with the biostatistician from the transplant surgery department to analyze the data. The student will also be involved in development of manuscript and abstract. The intent if the information in the study will be published in a transplant journal and will also be presented at one of the major transplant meetings (AST or ILTS) and participation of the student in these opportunities is encouraged. ; IRB Status - In process, supported by the transplant surgery department; Skills - Ability to evaluate the record for the information and record data | 0 | hammel@wisc.edu | Laura | Hammel | MD | Laura Hammel, hammel@wisc.edu -- Co-Mentor: Molly Groose, MD mgroose@wisc.edu | Associate Professor of Anesthiesology and Critical Care | 0 | Transplant Anesthesiology | Other | Critical Care | Molly Groose, MD | mgroose@wisc.edu | Anesthesiology | Transplant Anesthesiology | The Impact of Blood Flush on Post-Reperfusion Syndrome in Liver Transplantation | Hypothesis: Utilization of the blood flush technique in liver transplantation has significantly improved the severity of Post-Reperfusion Syndrome (PRS) and secondary outcomes including intraoperative cardiac arrest and death. This will be a retrospective chart review of the intra-operative hemodynamic changes that occur following reperfusion of the newly transplanted liver and the effects of adopting a practice of caval blood flush vent at the time of reperfusion over the traditional practice. Post-reperfusion syndrome (PRS) is a well-described and defined occurrence in liver transplantation that is associated with abrupt and life-threatening events including: profound hypotension refractory to vasopressors, intracardiac thrombosis, arrhythmias, cardiac arrest, severe acidosis, severe hyperkalemia, abrupt hypothermia and death. By using the blood flush technique via a caval vent, the initial 400 ml of blood effluent through the liver at reperfusion is evacuated rather than entering the systemic circulation. This practice appears to have significantly attenuated these life-threatening occurrences at reperfusion and the severity or PRS. A comparison of the intraoperative incidence and severity of the hemodynamic changes along with secondary outcomes, such as arrhythmia, hyperkalemia, intracardiac thrombosis, vasopressor use, CPR, cardiac arrest and death will be assessed in 400 patients or less who underwent liver transplantation at the University of Wisconsin Hospital before and after the adoption of blood flush technique. The study will be powered to assess for a 25% reduction in PRS | The student will be instructed on how to obtain information required from the Healthlink Anesthesia record for the purposes of this study and document the data. The student will be given access to departmental computers that are password protected and will work from our office so that all patient data and information will be protected. If needed the student will undergo HIPAA and other training as required by the University, To aid in the understanding of the process, the student will have an opportunity to shadow me or one of my transplant anesthesia colleagues during a liver transplantation. Once the data is collected, the student will work with the biostatistician from the transplant surgery department to analyze the data. The student will also be involved in development of manuscript and abstract. The intent if the information in the study will be published in a transplant journal and will also be presented at one of the major transplant meetings (AST or ILTS) and participation of the student in these opportunities is encouraged. | Once the student has been educated on how to extract the information from the record, the student will function on a very independent level, but the mentors will be available for all questions and for assistance at any time. | Ability to evaluate the record for the information and record data | In process, supported by the transplant surgery department | No | Yes | Yes | Not currently available to mentor other students | Stoll, et al. Post-Reperfusion Syndrome in Liver Transplantation: Does a Caval Blood Flush Vent Help? Annals of Transplant 2019:(24) ; 631 Bukowicka B, Akar RA, Olszewska A et al: The occurrence of postreperfusion syndrome in orthotopic liver transplantation and its significance in terms of complications and short-term survival. Ann Transplant, 2011; 16(2): 26–30 Hilmi I, Horton CN, Planinsic RM et al: The impact of postreperfusion syndrome on short-term patient and liver allograft outcome in patients undergoing orthotopic liver transplantation. Liver Transpl, 2008; 14(4): 504–8 Siniscalchi A, Gamberini L, Bardi T et al: Post-reperfusion syndrome during orthotopic liver transplantation, which definition best predicts postoperative graft failure and recipient mortality? J Crit Care, 2017; 41: 156–60 | Yes | Fern Reilly Human Resources fern.reilly@wisc.edu Kelly McQueen, MD Department Chair kelly.mcqueen@wisc.edu Tom Mcdowell, MD Chair of R and D committee thomas.mcdowell@wisc.edu Luis Ferndandez, MD Chief of Transplant Surgery luisf@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud6t6P4MX1Fxrhxl0N11fnTy42XEsMaywl31bCBQZjGXGTUrFfZl1nEMUfsk-cqWng |
| 30/12/2019 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Targeting Metabolic Stress in Cancer: The Cryns lab focuses on understanding how tumors adapt to and survive metabolic stress caused by their rapid growth. These metabolic adaptions are unique to cancer cells and represent promising drug targets to selectively eradicate tumors. We are particularly interested in translating these insights into improved cancer biomarkers and therapies. SPECIFIC PROJECTS INCLUDE: Regulation of metastasis by the cell stress protein αB-crystallin. We have identified αB-crystallin as a novel mediator of lung and brain metastasis in breast cancer that inhibits stress-induced apoptosis and promotes multiple steps in the metastatic cascade. We are actively investigating the mechanisms by which αB-crystallin promotes metastasis and developing strategies to therapeutically target this conserved stress response protein. Metabolic priming tumors to targeted therapies. We have developed a new therapeutic paradigm that uses a diet deficient in the amino acid methionine to metabolically prime tumor cells to die by increasing tumor expression of a cell death receptor (TRAIL-R2). Methionine restriction also reduces fat and improves metabolic health in mice. We are currently exploring the mechanisms underlying these effects and translating these observations into clinical trials in breast cancer. ____________________________________________________________________________ Role - research assistant; IRB Status - NA; Skills - Prior bench research experience is a plus but is not required | 1 | vlcryns@medicine.wisc.edu | Vincent | Cryns | MD | Vincent Cryns, vlcryns@medicine.wisc.edu -- Co-Mentor: | Professor of Medicine | 608 | Endocrinology, Diabetes and Metabolism | Targeting Metabolic Stress in Cancer | The Cryns lab focuses on understanding how tumors adapt to and survive metabolic stress caused by their rapid growth. These metabolic adaptions are unique to cancer cells and represent promising drug targets to selectively eradicate tumors. We are particularly interested in translating these insights into improved cancer biomarkers and therapies. SPECIFIC PROJECTS INCLUDE: Regulation of metastasis by the cell stress protein αB-crystallin. We have identified αB-crystallin as a novel mediator of lung and brain metastasis in breast cancer that inhibits stress-induced apoptosis and promotes multiple steps in the metastatic cascade. We are actively investigating the mechanisms by which αB-crystallin promotes metastasis and developing strategies to therapeutically target this conserved stress response protein. Metabolic priming tumors to targeted therapies. We have developed a new therapeutic paradigm that uses a diet deficient in the amino acid methionine to metabolically prime tumor cells to die by increasing tumor expression of a cell death receptor (TRAIL-R2). Methionine restriction also reduces fat and improves metabolic health in mice. We are currently exploring the mechanisms underlying these effects and translating these observations into clinical trials in breast cancer. | research assistant | Students will be mentored by other scientists in the lab and the PI | Prior bench research experience is a plus but is not required | NA | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Strekalova E, Malin D, Good DM, Cryns VL. Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL receptor-2 expression. Clin Cancer Res 2015 21: 2780-91. Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW. Short-term methionine deprivation improves metabolic health independently of mTORC1 and induces sexually dimorphic responses. FASEB J 2018; 32:3471-3482 Choi S, Chen M, Cryns VL, Anderson RA. A nuclear phosphoinositide kinase complex regulates p53. Nature Cell Biol 2019 21:462-475. | Yes | Jason Weitzman jweitzman@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud7vrqEXu64iXyOTRGUQ3_-K9NzI3o-MRyXjOAi47vyEbcMA0uUIgq6aqtadpbxkds | ||||||
| 30/12/2019 | Surgery | Shorter term projects | Understanding current practices and perspectives of medical educator development: Medical and surgical education are continuing to evolve. As training changes, we must also pay attention to the needs of our medical and surgical educators, most of whom have not had training in teaching and education methods. As such, a body of my work focuses on better understanding current systems of professional development in medical education and how physicians and other clinicians view themselves as medical educators. The project(s) available to a student include work on revising and validating a survey of self-efficacy as a medical educator and review of current professional development using a quantitative approach to network analysis called Epistemic Network Analysis (ENA). https://www.surgery.wisc.edu/staff/sarah-sullivan/ ____________________________________________________________________________ Role - Literature review, data collection and analysis with support, abstract and beginning manuscript preparation; IRB Status - Approved for the ENA project and in process for the survey; Skills - Strong verbal skills for conducting cognitive interviews for surveys - will be trained in this | 1 | jungs@surgery.wisc.edu | Sarah | Jung | PhD | Sarah Jung, jungs@surgery.wisc.edu -- Co-Mentor: | Assistant Professor (CHS) | 608 | Understanding current practices and perspectives of medical educator development | Medical and surgical education are continuing to evolve. As training changes, we must also pay attention to the needs of our medical and surgical educators, most of whom have not had training in teaching and education methods. As such, a body of my work focuses on better understanding current systems of professional development in medical education and how physicians and other clinicians view themselves as medical educators. The project(s) available to a student include work on revising and validating a survey of self-efficacy as a medical educator and review of current professional development using a quantitative approach to network analysis called Epistemic Network Analysis (ENA). https://www.surgery.wisc.edu/staff/sarah-sullivan/ | Literature review, data collection and analysis with support, abstract and beginning manuscript preparation | Strong verbal skills for conducting cognitive interviews for surveys - will be trained in this | Approved for the ENA project and in process for the survey | No | No (plan to use Dean's Office Funds) | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Operating room preparation by general surgery residents: A qualitative analysis. Goldwag JL, Jung S. Am J Surg. 2019 Dec 20. pii: S0002-9610(19)31572-7. doi: 10.1016/j.amjsurg.2019.12.020. [Epub ahead of print] PMID: 31882064 Teaching practicing surgeons what not to do: An analysis of instruction fluidity during a simulation-based continuing medical education course. Godfrey M, Rosser AA, Pugh CM, Shaffer DW, Sachdeva AK, Jung SA Surgery 2019 06; 165(6): 1082-1087 [PubMed ID: 30876670] The surgical consult entrustable professional activity (EPA): Defining competence as a basis for evaluation. Stucke RS, Sorensen M, Rosser A, Sullivan (Jung) S. Am J Surg. 2018 Dec 31. pii: S0002-9610(18)30522-1. doi: 10.1016/j.amjsurg.2018.12.056. [Epub ahead of print] PMID: 30616922 What do you want to know? Operative experience predicts the type of questions practicing surgeons ask during a CME laparoscopic hernia repair course. Godfrey M, Rosser AA, Pugh CM, Sachdeva AK, Sullivan (Jung) S Am. J. Surg. 2019 02; 217(2): 382-386 [PubMed ID: 30527925] Using epistemic network analysis to identify targets for educational interventions in trauma team communication. Sullivan (Jung) S, Warner-Hillard C, Eagan B, Thompson RJ, Ruis AR, Haines K, Pugh CM, Shaffer DW, Jung HS. Surgery. 2018 Apr;163(4):938-943. doi: 10.1016/j.surg.2017.11.009. Epub 2018 Feb 15. PMID: 29395240 | Yes | Sarah Pavao - pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf9AGBvnOj3TDw-bc-CoNBSbg5IuqALGq2MEMbr7CI9jvznHJfRvsvrxM944qSg2qc | ||||||||
| 16/01/2020 | Oncology | Shorter term projects | Survivorship Care of Adolescents and Young Adults with Cancer at the University of Wisconsin: This project aims to understand the survivorship experience of adolescents and young adults (AYA) diagnosed with cancer between 15- 39 years of age. With advances in cancer therapy, the numbers of cancer survivors are expected to continue growing. The cancer and survivorship experience of AYA patients is different from those diagnosed with cancer as children or as adults. The diagnosis of a cancer during the AYA period is particularly challenging as it affects a period of life when individuals are establishing their personal and social identity and balancing school, work, family relationships and learning to deal with sexuality, fertility, insurance and other responsibilities. Cancer survivors are at risk for a number of late effects from their treatment and AYA survivors are at an increased risk as they have many years ahead of them to potentially experience late effects. Many recent studies including ours have shown benefit from engaging in physical activity and adopting healthy behaviors but at the same time there are barriers to implementing recommendations. Our recent study (ref 2) found that younger individuals were less likely to be compliant with immunization guidelines. With this background, the current project involves surveying the AYA cancer survivors regarding their survivorship experience with a focus on health behaviors- physical activity, smoking, alcohol, recreational drug use and preventive care such as immunizations. The results of this survey would form the basis of identifying areas of need and designing subsequent interventional research studies for the AYA population seen at the University of Wisconsin, Madison ____________________________________________________________________________ Role - The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript. ; IRB Status - IRB exempt; Skills - literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing. | 0 | pophali@wisc.edu | Priyanka | Pophali | MD | Priyanka Pophali, pophali@wisc.edu -- Co-Mentor: Amye Tevaarwerk at4@medicine.wisc.edu | Assistant Professor | 6.082.639.295 | Hematology | Medicine | Amye Tevaarwerk | at4@medicine.wisc.edu | Oncology | Survivorship Care of Adolescents and Young Adults with Cancer at the University of Wisconsin | This project aims to understand the survivorship experience of adolescents and young adults (AYA) diagnosed with cancer between 15- 39 years of age. With advances in cancer therapy, the numbers of cancer survivors are expected to continue growing. The cancer and survivorship experience of AYA patients is different from those diagnosed with cancer as children or as adults. The diagnosis of a cancer during the AYA period is particularly challenging as it affects a period of life when individuals are establishing their personal and social identity and balancing school, work, family relationships and learning to deal with sexuality, fertility, insurance and other responsibilities. Cancer survivors are at risk for a number of late effects from their treatment and AYA survivors are at an increased risk as they have many years ahead of them to potentially experience late effects. Many recent studies including ours have shown benefit from engaging in physical activity and adopting healthy behaviors but at the same time there are barriers to implementing recommendations. Our recent study (ref 2) found that younger individuals were less likely to be compliant with immunization guidelines. With this background, the current project involves surveying the AYA cancer survivors regarding their survivorship experience with a focus on health behaviors- physical activity, smoking, alcohol, recreational drug use and preventive care such as immunizations. The results of this survey would form the basis of identifying areas of need and designing subsequent interventional research studies for the AYA population seen at the University of Wisconsin, Madison | The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript. | High | literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing. | IRB exempt | No | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students | 1. Pophali PA, et al. The Association of Physical Activity Before and After Lymphoma Diagnosis with survival outcomes. Am J Hematol. 2018 Dec;93(12):1543-1550. PMCID: PMC6386179 2. Pophali PA, et al. Compliance with cancer screening and influenza vaccination guidelines in Non-Hodgkin lymphoma survivors. Accepted for publication in the Journal of Cancer Survivorship. 3. Pophali PA, et al. The Association of Health Behaviors with Quality of Life in Lymphoma survivors (Manuscript under review) | Yes | Julene Gaspard | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudWoUg9uodEijJTTfCmuRnxmZsHtz8cciZ0odU0W218L4WJIg2BBXQUxQsQZflfFXk | ||
| 23/01/2020 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Hip Preservation versus Hip Replacement: In the Patients Indicated for Both, What Factors Determine the Choice of Surgery Type? : We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who are seen and evaluated by both a Hip Preservation surgeon (for hip arthroscopy) and a Hip Arthroplasty surgeon (for total hip replacement) over the preceding two year period. These patients are those who have more hip arthritis than the average hip preservation patient, but less arthritis than the typical hip replacement patient. We will analyze patient demographic factors, radiographic parameters, clinical exam findings, and focus on the factors which lead to the ultimate choice of the patient to undergo either a hip preservation surgery or a hip replacement surgery. We will also evaluate patient outcome of the chosen procedure based on patient reported outcome (PRO) measures. We would welcome the student to shadow in our orthopaedic clinics and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience as well. As part of this specific project, the student would be highly encouraged to observe the two procedures we are studying (hip arthroscopy and hip replacement) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient reported outcomes (PROs) into the repository (transcription from paper surveys into electronic surveys). Specific responsibilities pertaining to the retrospective project would be maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the lead mentor to discuss progress of the research as well as to follow a summer research curriculum. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - Pending; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | 0 | spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | Assistant Professor, Orthopedic Surgery, Sports Medicine & Hip Preservation | 608 | Sports Medicine | Other | Hip Preservation | Hip Preservation versus Hip Replacement: In the Patients Indicated for Both, What Factors Determine the Choice of Surgery Type? | We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who are seen and evaluated by both a Hip Preservation surgeon (for hip arthroscopy) and a Hip Arthroplasty surgeon (for total hip replacement) over the preceding two year period. These patients are those who have more hip arthritis than the average hip preservation patient, but less arthritis than the typical hip replacement patient. We will analyze patient demographic factors, radiographic parameters, clinical exam findings, and focus on the factors which lead to the ultimate choice of the patient to undergo either a hip preservation surgery or a hip replacement surgery. We will also evaluate patient outcome of the chosen procedure based on patient reported outcome (PRO) measures. We would welcome the student to shadow in our orthopaedic clinics and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience as well. As part of this specific project, the student would be highly encouraged to observe the two procedures we are studying (hip arthroscopy and hip replacement) to have a more complete understanding of the importance of this study. | A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient reported outcomes (PROs) into the repository (transcription from paper surveys into electronic surveys). Specific responsibilities pertaining to the retrospective project would be maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the lead mentor to discuss progress of the research as well as to follow a summer research curriculum. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | Pending | No | Yes | Yes | Not currently available to mentor other students | This would be a stand-alone project, so no related publications exist. The idea would be for the student to complete and be a published author on this project. | Yes | Heidi Ableidinger, Katie Schjei | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufJI8gEPHC-N_ip22e0whv6KWVn9BSudDan08gZCOFT8cRHvXU8ufqBtGOoMBvZHvo | ||||
| 23/01/2020 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | The Overlap of Pain Presentation in Patients with Hip or Back Pathology: We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a prospective review of patients who are seen and evaluated by both a Hip Preservation surgeon (for non-arthritic hip pain) and an orthopaedic spine surgeon (for back pain). While the hip and back are two distinct anatomic areas, the presentation of pain in patients with hip or back pathology is often very similar. To quantify the similarities and differences in these patient groups, patients in both clinics will fill out a form indicating where they are experiencing pain. We will then analyze the cross-over in pain locales in these two subsets of patients (hip pain and back pain) and determine the factors which lead to the most similarities. Analysis will include patient demographic factors, radiographic parameters, clinical exam findings, and ultimate patient diagnosis. We will also evaluate patient outcome based on patient reported outcome (PRO) measures. We would welcome the student to shadow in our orthopaedic clinics and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience as well. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (hip preservation and spine surgery) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient reported outcomes (PROs) into the repository (transcription from paper surveys into electronic surveys). Specific responsibilities pertaining to the prospective project would be maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the lead mentor to discuss progress of the research as well as to follow a summer research curriculum. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - Pending; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | 0 | spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Miranda Bice Bice@ortho.wisc.edu | The Overlap of Pain Presentation in Patients with Hip or Back Pathology | 6.082.346.716 | Sports Medicine | Other | Hip Preservation | Miranda Bice | Bice@ortho.wisc.edu | Orthopedics and Rehabilitation | Spine | The Overlap of Pain Presentation in Patients with Hip or Back Pathology | We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a prospective review of patients who are seen and evaluated by both a Hip Preservation surgeon (for non-arthritic hip pain) and an orthopaedic spine surgeon (for back pain). While the hip and back are two distinct anatomic areas, the presentation of pain in patients with hip or back pathology is often very similar. To quantify the similarities and differences in these patient groups, patients in both clinics will fill out a form indicating where they are experiencing pain. We will then analyze the cross-over in pain locales in these two subsets of patients (hip pain and back pain) and determine the factors which lead to the most similarities. Analysis will include patient demographic factors, radiographic parameters, clinical exam findings, and ultimate patient diagnosis. We will also evaluate patient outcome based on patient reported outcome (PRO) measures. We would welcome the student to shadow in our orthopaedic clinics and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience as well. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (hip preservation and spine surgery) to have a more complete understanding of the importance of this study. | A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient reported outcomes (PROs) into the repository (transcription from paper surveys into electronic surveys). Specific responsibilities pertaining to the prospective project would be maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the lead mentor to discuss progress of the research as well as to follow a summer research curriculum. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | Pending | No | Yes | Yes | Not currently available to mentor other students | This would be a stand-alone project, so no related publications exist. The idea would be for the student to complete and be a published author on this project. | Yes | Heidi Ableidinger, Katie Schjei | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufrZIDFVuxGAxn7HLXp-YmvPHfBcY-EQhzmoqQV542VNKSowln1eIXdXI_QEP6TCb0 |
| 02/01/2020 | Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Standardizing the measurement of self-reported injection therapy adherence for treatment of type 2 diabetes mellitus: Nonadherence to injectable therapies for patients with type 2 diabetiesdiabetes mellitus (T2DM) often leads to hyperglycemia, which in turn leads to several types of vascular complications, significant morbidity, and increased health care costs. A standardized method for assessing injectable medication nonadherence in patients with T2DM will help researchers and clinicians alike to identify patients who have difficulty adhering so that interventions can be tailored appropriately. We previously developed a self-report measure to assess adherence to oral medications. We will conduct formative research to determine to what extent the measure must be modified to capture nonadherence to injectable medications for T2DM. We will compile a list of common reasons for nonadherence from existing literature. We will then create and email a REDCap survey to current T2DM patients to confirm our current list of reasons and identify new reasons that are not represented in our specific reasons measure (a content validity issue). Additionally, we will conduct cognitive interviews with up to 15 T2DM patients to ensure that the questions are comprehensible, easy to answer, and measure what they are intended to measure. We will also conduct interviews with physicians, advanced practice providers, and diabetes educators in the University of Wisconsin School of Medicine and Public Health Department of Medicine Endocrinology, Diabetes and Metabolism--key stakeholders who would be in the position to use such a measure--to evaluate the content validity and the feasibility of using the measure in research studies and in clinical practice. This approach will improve the quality, objectivity, and impact of patient-centered research related to medication adherence to better relate outcomes with varying levels of nonadherence. Please schedule a meeting with Dr. Voils and Kara Gavin by contacting Drew Giordana at giordana@surgery.wisc.edu ____________________________________________________________________________ Role - Will discuss at meeting; IRB Status - Approved ; Skills - Prior Experience not required | 1 | voils@surgery.wisc.edu | Corrine | Voils | PhD | Corrine Voils, voils@surgery.wisc.edu -- Co-Mentor: Kara Gavin gavin@surgery.wisc.edu | Professor, Scientific Director WISOR, Vice Chair for Diversity, Equity, and Inclusion | 608 | Division of Minimally Invasive Surgery | Kara Gavin | gavin@surgery.wisc.edu | Surgery | Standardizing the measurement of self-reported injection therapy adherence for treatment of type 2 diabetes mellitus | Nonadherence to injectable therapies for patients with type 2 diabetiesdiabetes mellitus (T2DM) often leads to hyperglycemia, which in turn leads to several types of vascular complications, significant morbidity, and increased health care costs. A standardized method for assessing injectable medication nonadherence in patients with T2DM will help researchers and clinicians alike to identify patients who have difficulty adhering so that interventions can be tailored appropriately. We previously developed a self-report measure to assess adherence to oral medications. We will conduct formative research to determine to what extent the measure must be modified to capture nonadherence to injectable medications for T2DM. We will compile a list of common reasons for nonadherence from existing literature. We will then create and email a REDCap survey to current T2DM patients to confirm our current list of reasons and identify new reasons that are not represented in our specific reasons measure (a content validity issue). Additionally, we will conduct cognitive interviews with up to 15 T2DM patients to ensure that the questions are comprehensible, easy to answer, and measure what they are intended to measure. We will also conduct interviews with physicians, advanced practice providers, and diabetes educators in the University of Wisconsin School of Medicine and Public Health Department of Medicine Endocrinology, Diabetes and Metabolism--key stakeholders who would be in the position to use such a measure--to evaluate the content validity and the feasibility of using the measure in research studies and in clinical practice. This approach will improve the quality, objectivity, and impact of patient-centered research related to medication adherence to better relate outcomes with varying levels of nonadherence. Please schedule a meeting with Dr. Voils and Kara Gavin by contacting Drew Giordana at giordana@surgery.wisc.edu | Will discuss at meeting | Prior Experience not required | Approved | Yes | Yes | Yes | PhD students | Will review at time of meeting | Yes | Kara Gavin gavin@surgery.wisc.edu; Sarah Pavao pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuem2S7vHk-b5VhvFYScp8syx0u0o8kfpHE2r6FcDqcTmk90Ue-1vIwLQXzRGJoyKf4 | ||||
| 02/01/2020 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Optimizing NK cells for cancer immunotherapy: We are testing various methods to expand and activate NK cells to kill pediatric cancers. Projects will be tailored to the student's background and interest. Interest in immunology required. For more info, go to our website: https://www.pediatrics.wisc.edu/research/research-groups/capitini/ ____________________________________________________________________________ Role - Student Researcher; IRB Status - N/A; Skills - Pipetting, calculating dilutions, comfort in handling mice | 0 | ccapitini@pediatrics.wisc.edu | Christian | Capitini | MD | Christian Capitini, ccapitini@pediatrics.wisc.edu -- Co-Mentor: | Assistant Professor | 262 | Hematology, Oncology and Bone Marrow Transplant | Optimizing NK cells for cancer immunotherapy | We are testing various methods to expand and activate NK cells to kill pediatric cancers. Projects will be tailored to the student's background and interest. Interest in immunology required. For more info, go to our website: https://www.pediatrics.wisc.edu/research/research-groups/capitini/ | Student Researcher | Pipetting, calculating dilutions, comfort in handling mice | N/A | Yes | Yes | Yes | Not currently available to mentor other students | Damodharan SN*, Walker KL*, McDowell KA, Bouchlaka MN, Drier DA, Sondel PM, DeSantes KB, Capitini CM: Analysis of ex vivo expanded and activated clinical grade human NK cells after cryopreservation. Cytotherapy, manuscript under revision. * = co-first authors Lieberman NAP, DeGolier K, Haberthur K, Chinn H, Moyes KW, Bouchlaka MN, Walker KL, Capitini CM, Crane CA: An uncoupling of canonical phenotypic markers and functional potency of ex vivo expanded natural killer cells. Frontiers in Immunology 2018 Feb 2; 9:150. PMCID: PMC5801405 Bouchlaka MN, Ludwig KD, Gordon JW, Kutz MP, Bednarz B, Fain SB, Capitini CM: 19F-MRI for monitoring human NK cells in vivo. Oncoimmunology 2016; 5(5):e1143996. PMCID: PMC4910731 | Yes | Nate Miller at nwmiller2@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud-FVi4Dpac6YGVxRoRIbXNrcZD2_F9ckIYYw4_SOA0-6_dnzLJTqUH79U3BmcvzqE | |||||||
| 06/01/2020 | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Artificial Intelligence to improve magnetic resonance imaging (MRI) and positron emission tomography (PET): Our group is actively exploring the application of artificial intelligence (AI) and deep learning to improve medical imaging. We are focusing on the applications in magnetic resonance imaging and positron emission tomography. Problem areas of interest include disease classification, image segmentation, and advanced physics-based reconstructions. More information about the group is available on our website: https://mimrtl.wiscweb.wisc.edu/ ____________________________________________________________________________ Role - Student will develop and apply deep learning techniques to medical images; IRB Status - approved; Skills - proficient experience in Python computer programming, working knowledge of machine learning, strong interpersonal and collaborative skills are necessary | 2 | abmcmillan@wisc.edu | Alan | McMillan | PhD | Alan McMillan, abmcmillan@wisc.edu -- Co-Mentor: | Associate Professor | 6.082.622.622 | Artificial Intelligence to improve magnetic resonance imaging (MRI) and positron emission tomography (PET) | Our group is actively exploring the application of artificial intelligence (AI) and deep learning to improve medical imaging. We are focusing on the applications in magnetic resonance imaging and positron emission tomography. Problem areas of interest include disease classification, image segmentation, and advanced physics-based reconstructions. More information about the group is available on our website: https://mimrtl.wiscweb.wisc.edu/ | Student will develop and apply deep learning techniques to medical images | Moderate | proficient experience in Python computer programming, working knowledge of machine learning, strong interpersonal and collaborative skills are necessary | approved | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | https://www.ncbi.nlm.nih.gov/myncbi/alan.mcmillan.1/bibliography/public/ | Yes | Lorene Seman - LSeman@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueXhKH9mMpveFKnOCnlf-8MzowH-U5hOd64gLZLYWHmhL8Rhs3Len8ZxGTIKsxj2H4 | |||||||
| 07/01/2020 | Orthopedics and Rehabilitation | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Predicting Need For Microfracture During Hip Arthroscopy: Retrospective chart review. The aim of this project is to determine important predictors of requiring microfracture at the time of hip arthroscopy. The student will be required to review medical charts for data to populate a model to answer the above question. ____________________________________________________________________________ Role - Data acquisition and analysis. Possibly predictive statistical modeling if interested.; IRB Status - Currently approved.; Skills - Orthopedic interest. Detail oriented and organized for data collection. Comfort with Microsoft Excel. | 1 | walczak@ortho.wisc.edu | Brian | Walczak | DO | Brian Walczak, walczak@ortho.wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.635.636 | Sports Medicine | Predicting Need For Microfracture During Hip Arthroscopy | Retrospective chart review. The aim of this project is to determine important predictors of requiring microfracture at the time of hip arthroscopy. The student will be required to review medical charts for data to populate a model to answer the above question. | Data acquisition and analysis. Possibly predictive statistical modeling if interested. | Moderate. Training will be provided. | Orthopedic interest. Detail oriented and organized for data collection. Comfort with Microsoft Excel. | Currently approved. | No | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students | 1. Does the Use of Psychotropic Medication Adversely Affect the Outcomes of Hip Arthroscopy? Youlo ST, Walczak BE, Keene JS. Am J Sports Med. 2018 Dec;46(14):3423-3428. doi: 10.1177/0363546518801881. Epub 2018 Oct 26. PMID: 30365348 Free PMC Article 2. Magnetic Resonance Imaging Appearance of the Hip Musculature After Arthroscopic Labral-Level Iliopsoas Tenotomies. Walczak BE, Blankenbaker DG, Tuite MR, Keene JS. Orthop J Sports Med. 2017 May 25;5(5):2325967117707498. doi:10.1177/2325967117707498. eCollection 2017 May. PMID: 28596974 | Yes | 1. Deb Brauer: brauer@ortho.wisc.edu 2. Tina Bugel: bugel@ortho.wisc.edu 3. Jennifer Wang: jtwang@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud0X7TCkNIC-1Ln7-O3zWFURa6-EovwoRPqHIaJWKPBwfZLZ8lKTun6BUPM1zY9r1M | ||||||
| 08/01/2020 | Obstetrics & Gynecology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Telecontraception : Using the patient population who utilizes University Health Services, the goal of our project is to determine whether utilizing telehealth contraception visits instead of a traditional in-person contraception visit will result in similar rates of adherence to recommended preventative health practices. These recommended preventative health practices include an annual blood pressure measurement, guideline based cervical cancer screening, and annual sexually transmitted infection screening. Secondarily, we will also assess if methods of contraception differ between the telehealth and in-person contraception groups. By showing that preventative health adherence rates do not differ between groups, we hope to show that telehealth is a safe and effective way of providing contraception to those who have barriers to in-person healthcare visits. ____________________________________________________________________________ Role - We anticipate the student's role will be comprised mainly of chart review and potentially some literature review and simple statistical analysis. ; IRB Status - N/A; Skills - Proficient in excel and basic statistical analysis. Will be trained on how to access and use the electronic medical record at University Health Services. | 1 | Mary.Landry@wisc.edu | Mary | Landry | MD | Mary Landry, Mary.Landry@wisc.edu -- Co-Mentor: Rachel Mojdehbakhsh, MD PGY-1 rmojdehbakhsh@uwhealth.org | Manager, Women's Health Clinic | 0 | University Health Services | Rachel Mojdehbakhsh, MD PGY-1 | rmojdehbakhsh@uwhealth.org | Obstetrics & Gynecology | Telecontraception | Using the patient population who utilizes University Health Services, the goal of our project is to determine whether utilizing telehealth contraception visits instead of a traditional in-person contraception visit will result in similar rates of adherence to recommended preventative health practices. These recommended preventative health practices include an annual blood pressure measurement, guideline based cervical cancer screening, and annual sexually transmitted infection screening. Secondarily, we will also assess if methods of contraception differ between the telehealth and in-person contraception groups. By showing that preventative health adherence rates do not differ between groups, we hope to show that telehealth is a safe and effective way of providing contraception to those who have barriers to in-person healthcare visits. | We anticipate the student's role will be comprised mainly of chart review and potentially some literature review and simple statistical analysis. | Should be able to work independently on chart review once trained. Will have opportunity to meet with Dr. Landry at UHS on a weekly basis. | Proficient in excel and basic statistical analysis. Will be trained on how to access and use the electronic medical record at University Health Services. | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | N/A | Yes | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufdHNQ2iCnCbN6wwbijatrz8Ki4JTxQXnVwsUFkHZMgLMVzo37wxlxm0vvUtsvBKAU | |||
| 08/01/2020 | Medical History and Bioethics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Student experiences of "failures to replicate": In the past decade, issues about the reproducibility of biomedical research (especially preclinical biomedical research) have gained widespread attention. One paper published by pharmaceutical industry scientists reported that they could only reproduce findings from preclinical research 11% of the time, a finding that attracted much attention in both the science policy community and the popular press. Another survey conducted by Nature publishing group reported that nearly two thirds of medical researchers had failed to reproduce a result at some point in their careers. But if failures to replicate research in biomedicine are so common, why did it take so long for the problem to come to light? To answer this question, my research group is interviewing trainee scientists (both undergrads and grad students) who have experienced a failure to replicate. Often, when an experiment fails to replicate, it is not clear why: Is it the trainee's lack of skill? A malfunctioning piece of equipment? Something wrong with the original result? Given the interpretive flexibility of the situation, we are interested in understanding which interpretations trainee scientists tend to attach to these events, and the corresponding actions that they take. We are especially interested in whether trainee scientists might be more likely to attribute to replicate to their own lack of skill rather than external sources, and if women and/or minority scientists might be especially inclined to interpret events this way. We hope to identify trends in trainee reactions, and to identify productive and problematic ways in which trainees and advisors respond to experiences of irreproducibility. This research has important implications for graduate student mental health, for retention of women and minorities, and for the robustness of the biomedical literature. If trainee scientists are likely to dismiss findings of irreproducibility (or be dismissed by their advisors when they bring them forward), this presents risks for trainee mental health and results in missed opportunities to correct the scientific record. ____________________________________________________________________________ Role - Students will analyze transcripts of interviews with undergraduate students, and recruit and conduct interviews with graduate students who are enrolled in NIH training programs on the UW Madison campus.; IRB Status - Already approved; Skills - Semi-structured interviewing and qualitative data analysis. I can provide training in these skills if needed. | 2 | nicole.nelson@wisc.edu | Nicole | Nelson | PhD | Nicole Nelson, nicole.nelson@wisc.edu -- Co-Mentor: | Assistant Professor | 6.082.653.525 | Student experiences of "failures to replicate" | In the past decade, issues about the reproducibility of biomedical research (especially preclinical biomedical research) have gained widespread attention. One paper published by pharmaceutical industry scientists reported that they could only reproduce findings from preclinical research 11% of the time, a finding that attracted much attention in both the science policy community and the popular press. Another survey conducted by Nature publishing group reported that nearly two thirds of medical researchers had failed to reproduce a result at some point in their careers. But if failures to replicate research in biomedicine are so common, why did it take so long for the problem to come to light? To answer this question, my research group is interviewing trainee scientists (both undergrads and grad students) who have experienced a failure to replicate. Often, when an experiment fails to replicate, it is not clear why: Is it the trainee's lack of skill? A malfunctioning piece of equipment? Something wrong with the original result? Given the interpretive flexibility of the situation, we are interested in understanding which interpretations trainee scientists tend to attach to these events, and the corresponding actions that they take. We are especially interested in whether trainee scientists might be more likely to attribute to replicate to their own lack of skill rather than external sources, and if women and/or minority scientists might be especially inclined to interpret events this way. We hope to identify trends in trainee reactions, and to identify productive and problematic ways in which trainees and advisors respond to experiences of irreproducibility. This research has important implications for graduate student mental health, for retention of women and minorities, and for the robustness of the biomedical literature. If trainee scientists are likely to dismiss findings of irreproducibility (or be dismissed by their advisors when they bring them forward), this presents risks for trainee mental health and results in missed opportunities to correct the scientific record. | Students will analyze transcripts of interviews with undergraduate students, and recruit and conduct interviews with graduate students who are enrolled in NIH training programs on the UW Madison campus. | Moderate | Semi-structured interviewing and qualitative data analysis. I can provide training in these skills if needed. | Already approved | No | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | I'm in the beginning stages of this project and so don't have any publications yet that are of direct relevance. The most related would be Chapter One of my book Model Behavior (2018, University of Chicago Press), which describes student experiences of conducting research in animal behavior genetics. | No | Jean von Allmen (jmvonall@wisc.edu ) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudJk7TfWwMCjLUtXkmWHOOzGtyUIad5ufXGro7HsDBYy3uRwx_N_K0i30y-ukRPZBs | |||||||
| 08/01/2020 | Medicine | Shorter term projects | How the acute cellular rejection in the kidney transplant recipients should be treated? : How the acute cellular rejection in the kidney transplant recipients should be treated? In general, the episodes of acute cellular rejection have been associated with a reduction in long-term allograft survival. The impact of successfully treating acute TCMR on graft outcomes has not been well studied. Further, the adequate treatment of different grades of TCMR is not well known and is variable from center to center. The purpose of the study is to look into adequate treatment of the different grades of rejection. ____________________________________________________________________________ Role - Data collection, Manuscript writing; IRB Status - Approved; Skills - No | 0 | faziz@wisc.edu | Fahad | Aziz | MD | Fahad Aziz, faziz@wisc.edu -- Co-Mentor: | Assistant Professor | 3.474.616.570 | Nephrology | How the acute cellular rejection in the kidney transplant recipients should be treated? | How the acute cellular rejection in the kidney transplant recipients should be treated? In general, the episodes of acute cellular rejection have been associated with a reduction in long-term allograft survival. The impact of successfully treating acute TCMR on graft outcomes has not been well studied. Further, the adequate treatment of different grades of TCMR is not well known and is variable from center to center. The purpose of the study is to look into adequate treatment of the different grades of rejection. | Data collection, Manuscript writing | No | Approved | No | No (plan to use Dean's Office Funds) | No | UW undergraduates interested in research | Efficacy of Acute Cellular Rejection Treatment According to Banff Score in Kidney Transplant Recipients: A Systematic Review. Treatment of acute T cell-mediated (cellular) rejection of the renal allograft - uptodate | No | Samantha Strennan (sjthomps@medicine.wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud4L7xkq7s69D7Cq2dXfcNSwD2U9h4YQpMcF7RYCMIxrUC2dInlyhbdEEqWWel0fu4 | |||||||
| 09/01/2020 | Medicine | Shorter term projects | Association between hypomagnesemia post kidney transplantation and subsequent cardiovascular events: Is hypomagnesemia at 1 year after transplant predictive of subsequent 1) arrhythmias, 2) ischemic cardiovascular events, 3) heart failure, 4) graft and 5) patient outcomes? In the era of CNI use, hypomagnesemia is a very common finding in kidney transplant recipients. It is associated with higher mortality and cardiovascular events in the general population, but the association has not been explored in kidney transplant recipients. Studying this association is important given that cardiovascular disease is the most common cause of death in this population. ____________________________________________________________________________ Role - Literature review, coordinate data analysis with statistician, writing; IRB Status - Covered under blanket kidney transplant IRB; Skills - Literature review | 0 | ngarg@medicine.wisc.edu | Neetika | Garg | MD | Neetika Garg, ngarg@medicine.wisc.edu -- Co-Mentor: Arjang Djamali axd@medicine.wisc.edu | Assistant Professor | 6.176.507.026 | Nephrology | Arjang Djamali | axd@medicine.wisc.edu | Medicine | Nephrology | Association between hypomagnesemia post kidney transplantation and subsequent cardiovascular events | Is hypomagnesemia at 1 year after transplant predictive of subsequent 1) arrhythmias, 2) ischemic cardiovascular events, 3) heart failure, 4) graft and 5) patient outcomes? In the era of CNI use, hypomagnesemia is a very common finding in kidney transplant recipients. It is associated with higher mortality and cardiovascular events in the general population, but the association has not been explored in kidney transplant recipients. Studying this association is important given that cardiovascular disease is the most common cause of death in this population. | Literature review, coordinate data analysis with statistician, writing | Intermediate | Literature review | Covered under blanket kidney transplant IRB | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | PMID 30704880 (Metabolic Acidosis 1 Year Following Kidney Transplantation and Subsequent Cardiovascular Events and Mortality: An Observational Cohort Study) and 24609888 (Lower magnesium level associated with new-onset diabetes and pre-diabetes after kidney transplantation) | No | Dr. Arjang Djamali | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnude5Hcsxb9uV6lc9kxBH2ib8eP1dtAlWSrpu8wjtYdWGq1ijn52nQsSQNfVmYF_luE | ||
| 13/02/2020 | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Optimization of pelvic 3D DSA for prostate artery embolization in an animal model: This project aims to optimize 3D digital subtraction angiograpic imaging of the pelvis in order to guide prostate artery embolization. We will perform catheter angiography of the pelvis in swine with varying imaging parameters in order to best identify and trace the course of the bilateral prostatic arteries. This translational project will have direct clinical application. ____________________________________________________________________________ Role - Primary data collection, image and data analysis, abstract/manuscript preparation; IRB Status - N/A; Skills - Basic knowledge of Microsoft office tools | 0 | aeifler@wisc.edu | Aaron | Eifler | MD | Aaron Eifler, aeifler@wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Interventional Radiology | Optimization of pelvic 3D DSA for prostate artery embolization in an animal model | This project aims to optimize 3D digital subtraction angiograpic imaging of the pelvis in order to guide prostate artery embolization. We will perform catheter angiography of the pelvis in swine with varying imaging parameters in order to best identify and trace the course of the bilateral prostatic arteries. This translational project will have direct clinical application. | Primary data collection, image and data analysis, abstract/manuscript preparation | Basic knowledge of Microsoft office tools | N/A | Yes | Yes | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Kobe, A., Puippe, G., Klotz, E., Alkadhi, H., & Pfammatter, T. (2019). Computed Tomography for 4-Dimensional Angiography and Perfusion Imaging of the Prostate for Embolization Planning of Benign Prostatic Hyperplasia. Investigative Radiology, 16(1), 15–23. | Yes | aeifler@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudraUobEPbjm4uh2eubA7_lCaGCQ_qn0FHiGEHAKuMTleJBq7939FANrzC8fLwKWpQ | |||||||
| 13/02/2020 | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Disparities in percutaneous lung biopsy for rural versus urban veterans: This project aims to elucidate the effect of rurality on the timliness of lung cancer diagnosis via CT-guided percutaneous lung biopsy. We will also investigate the rates of admission following this procedure in this patient population. ____________________________________________________________________________ Role - Mentored Data collection, Data Analysis, Abstract and Manuscript preparation, Presentation; IRB Status - N/A; Skills - No specific skills required | 0 | aeifler@wisc.edu | Aaron | Eifler | MD | Aaron Eifler, aeifler@wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Interventional Radiology | Disparities in percutaneous lung biopsy for rural versus urban veterans | This project aims to elucidate the effect of rurality on the timliness of lung cancer diagnosis via CT-guided percutaneous lung biopsy. We will also investigate the rates of admission following this procedure in this patient population. | Mentored Data collection, Data Analysis, Abstract and Manuscript preparation, Presentation | No specific skills required | N/A | Yes | Yes | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Douthit, N., Kiv, S., Dwolatzky, T., & Biswas, S. (2015). Exposing some important barriers to health care access in the rural USA; Cook, P. S. (2018). The Challenges of Providing Interventional Radiology Services to Rural and Smaller Community Hospitals. AJR. American Journal of Roentgenology, 211(4), 744–747 | Yes | aeifler@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufFPxQiMPk2oRYZYIcVjvTv8RdOikH5oPB94KQIQn6Z1hSMeya7ZuGx_ZqIwgupef8 | |||||||
| 27/01/2020 | Neurological Surgery | Shorter term projects, Research Electives for credit | Pediatric Spine Growth and Biomechanics in Normal and Syndromic Populations: Our team studies the biomechanics of the growing pediatric spine to better understand normal development and pathological states, with a particular interest in novel applications of minimally invasive surgical techniques in the pediatric population. Depending on interests and skills, a student would be engaged in a variety of focused clinical projects that typically involve collaboration with the pediatrics, neuroradiology, engineering, and surgical teams. ____________________________________________________________________________ Role - Data collection and analysis, manuscript preparation, independent project development as interested; IRB Status - Approved; Skills - Organizational and analytical skills | 0 | stadler@neurosurgery.wisc.edu | James | Stadler | MD | James Stadler, stadler@neurosurgery.wisc.edu -- Co-Mentor: | Pediatric Spinal Growth and Biomechanics | 6.082.620.687 | Pediatric Neurosurgery | Pediatrics | Pediatric Spine Growth and Biomechanics in Normal and Syndromic Populations | Our team studies the biomechanics of the growing pediatric spine to better understand normal development and pathological states, with a particular interest in novel applications of minimally invasive surgical techniques in the pediatric population. Depending on interests and skills, a student would be engaged in a variety of focused clinical projects that typically involve collaboration with the pediatrics, neuroradiology, engineering, and surgical teams. | Data collection and analysis, manuscript preparation, independent project development as interested | Organizational and analytical skills | Approved | No | No (plan to use Dean's Office Funds) | Yes | DPT students, Genetic Counseling students, MPH students, UW undergraduates interested in research | - Pediatric Holocord Epidural Abscess Treated with Apical Laminotomies with Catheter-directed Irrigation and Drainage - Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF) in Children - A Novel Clinical Application of 3D Interactive Virtual Reality Technology in Pediatric Patients with Spinal Pathology - Preserved Segmental Range Of Motion With Temporary Percutaneous Pedicle Instrumentation In Children And Young Adults With Unstable Thoracolumbar Fractures - Use of fibrin sealant for refractory CSF leak in children - Radiographic parameters predictive of cervicomedullary compression in infants with achondroplasia | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudOLyqpr1TNbzGA2ilbxtHx_7LuJn-FQ_cef2i-cOvuL5-J6OqFqkB328OI0_OZ7TE | ||||||
| 12/01/2020 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Wisconsin Alzheimer's Disease Research Center: Community Collaborations with the Oneida Nation of Wisconsin and Black Leaders from Brain Health: The project aims respond to community-initiated connections with the Wisconsin Alzheimer’s Disease Research Center (ADRC). In our experience, responding to community requests improves research study recruitment and retention. The activities represent partnerships with two groups under-represented in Alzheimer’s and Related Dementia (ADRD) research – Blacks and American Indians. The work proposed will be led by the Inclusion of Under-Represented Group (IURG) Core of the Wisconsin ADRC. The overarching goal is to expand community-based recruitment and retention activities by supporting collaborative initiatives between the IURG Core and Community Advisory Boards (CABs). Specific Aims for this supplement represent initiatives proposed by two community groups. The Oneida CAB proposed four Specific Aims to be accomplished during the funding period of the Wisconsin Alzheimer’s Disease Research Center (ADRC) P30 funding. The Black Leaders for Brain Health will accomplish three Specific Aims. In 2015, the Oneida Nation of Wisconsin’s Elder leaders (the Oneida Nation Commission on Aging; ONCOA) approached the Wisconsin ADRC IURG Core looking to build a liaison with researchers studying ADRD. Ultimately, their goals were to improve care for elders with dementia and assist families caring for a family member with dementia. Importantly, interest in research participation was not the primary motivation for contacting the Wisconsin ADRC. We responded accordingly, implementing an NIA-funded, community-based and community-led, culturally-relevant approach to address the ONCOA’s goals. Although not the primary goal, the work done and relationships developed as a result of our collaboration have helped us address barriers to participation in ADRD research. Prior funding addressed four aims: (1) Establish a Community Advisory Board (CAB) to guide culturally-tailored outreach programs and research endeavors, (2) Improve access to culturally appropriate dementia diagnostic services, (3) Survey of Oneida caregivers of persons with dementia to understand caregiving experiences, and (4) Initiate liaisons with ten other Wisconsin tribes. Of note, 57 of the 248 American Indians (AI) enrolled (23%) in the National Alzheimer’s Coordinating Center (NACC) were recruited at the Wisconsin ADRC, more than half of whom were recruited since the initiation of our efforts. We propose the following four new aims, developed in collaboration with the Oneida CAB: Specific Aim 1: Continue the Oneida Alzheimer’s and Related Dementias Community Advisory Board “Oneida Alzheimer’s CAB” to guide a culturally tailored outreach, education and research. Specific Aim 2: Reach middle-aged adults, military Veterans and youth with Dementia Curriculum. Specific Aim 3: Work to reduce stigma associated with Alzheimer’s and Related Dementias by providing outreach and education. Specific Aim 4: Continue efforts to optimize access to culturally competent dementia diagnostics. We were recently approached by a preeminent leader in Madison’s Black community. The Reverend Dr. Alexander Gee asked our program to host an informational session and tour of the Wisconsin ADRC for local Black Leaders invested in addressing ADRD in the Black Community. We enthusiastically responded to this opportunity. In additional to his National leadership as a Black Pastor, the Rev. Dr. Gee leads the Justified Anger movement in Madison. Among the organization’s agendas is the goal to achieve health equity. Rev. Dr. Gee would like to include ADRD among the health conditions addressed first, as he has seen the disease’s effect first hand. He tells his story in a Blog post about his mother’s Alzheimer’s disease dementia. https://www.alexgee.com/my-mom-has-alzheimers-disease/. On May 21, 2019 we held our inaugural Black Leaders for Brain Health event. Seventeen local Black Leaders attended and heard from seven emerging scientists whose work is relevant to the Black community. Under the joint leadership of Dr. Gee and Dr. Gleason, the Black Leaders activities will build an informed group of advisors to guide the Center’s science. We seek funding to support three Aims related to our collaboration with “Black Leaders for Brain Health”: Specific Aim 1: Develop the Black Leaders for Brain Health group to guide a responsive research program and culturally tailored outreach to Madison’s Black community. Specific Aim 2: Provide educational events in Black churches and community centers located “across the isthmus” of the Madison metropolitan area. Specific Aim 3: Respond to requests from members of the Black Leaders for Brain Health. For example, we want to be prepared to provide training on scientific design, human subject regulations, the ATN criteria as they prioritize the community’s needs and interests. In brief, we seek funding for two years of support for two community-led collaborations directed toward several new initiatives, through which we will support community based participatory research ____________________________________________________________________________ Role - Role can be determined based on student's skill set and interest; IRB Status - N/A; Skills - Ability to connect to African American and/or American Indian Communities | 2 | ceg@medicine.wisc.edu | Carey | Gleason | PhD | Carey Gleason, ceg@medicine.wisc.edu -- Co-Mentor: | Associate Professor | 608 | Geriatrics | Wisconsin Alzheimer's Disease Research Center: Community Collaborations with the Oneida Nation of Wisconsin and Black Leaders from Brain Health | The project aims respond to community-initiated connections with the Wisconsin Alzheimer’s Disease Research Center (ADRC). In our experience, responding to community requests improves research study recruitment and retention. The activities represent partnerships with two groups under-represented in Alzheimer’s and Related Dementia (ADRD) research – Blacks and American Indians. The work proposed will be led by the Inclusion of Under-Represented Group (IURG) Core of the Wisconsin ADRC. The overarching goal is to expand community-based recruitment and retention activities by supporting collaborative initiatives between the IURG Core and Community Advisory Boards (CABs). Specific Aims for this supplement represent initiatives proposed by two community groups. The Oneida CAB proposed four Specific Aims to be accomplished during the funding period of the Wisconsin Alzheimer’s Disease Research Center (ADRC) P30 funding. The Black Leaders for Brain Health will accomplish three Specific Aims. In 2015, the Oneida Nation of Wisconsin’s Elder leaders (the Oneida Nation Commission on Aging; ONCOA) approached the Wisconsin ADRC IURG Core looking to build a liaison with researchers studying ADRD. Ultimately, their goals were to improve care for elders with dementia and assist families caring for a family member with dementia. Importantly, interest in research participation was not the primary motivation for contacting the Wisconsin ADRC. We responded accordingly, implementing an NIA-funded, community-based and community-led, culturally-relevant approach to address the ONCOA’s goals. Although not the primary goal, the work done and relationships developed as a result of our collaboration have helped us address barriers to participation in ADRD research. Prior funding addressed four aims: (1) Establish a Community Advisory Board (CAB) to guide culturally-tailored outreach programs and research endeavors, (2) Improve access to culturally appropriate dementia diagnostic services, (3) Survey of Oneida caregivers of persons with dementia to understand caregiving experiences, and (4) Initiate liaisons with ten other Wisconsin tribes. Of note, 57 of the 248 American Indians (AI) enrolled (23%) in the National Alzheimer’s Coordinating Center (NACC) were recruited at the Wisconsin ADRC, more than half of whom were recruited since the initiation of our efforts. We propose the following four new aims, developed in collaboration with the Oneida CAB: Specific Aim 1: Continue the Oneida Alzheimer’s and Related Dementias Community Advisory Board “Oneida Alzheimer’s CAB” to guide a culturally tailored outreach, education and research. Specific Aim 2: Reach middle-aged adults, military Veterans and youth with Dementia Curriculum. Specific Aim 3: Work to reduce stigma associated with Alzheimer’s and Related Dementias by providing outreach and education. Specific Aim 4: Continue efforts to optimize access to culturally competent dementia diagnostics. We were recently approached by a preeminent leader in Madison’s Black community. The Reverend Dr. Alexander Gee asked our program to host an informational session and tour of the Wisconsin ADRC for local Black Leaders invested in addressing ADRD in the Black Community. We enthusiastically responded to this opportunity. In additional to his National leadership as a Black Pastor, the Rev. Dr. Gee leads the Justified Anger movement in Madison. Among the organization’s agendas is the goal to achieve health equity. Rev. Dr. Gee would like to include ADRD among the health conditions addressed first, as he has seen the disease’s effect first hand. He tells his story in a Blog post about his mother’s Alzheimer’s disease dementia. https://www.alexgee.com/my-mom-has-alzheimers-disease/. On May 21, 2019 we held our inaugural Black Leaders for Brain Health event. Seventeen local Black Leaders attended and heard from seven emerging scientists whose work is relevant to the Black community. Under the joint leadership of Dr. Gee and Dr. Gleason, the Black Leaders activities will build an informed group of advisors to guide the Center’s science. We seek funding to support three Aims related to our collaboration with “Black Leaders for Brain Health”: Specific Aim 1: Develop the Black Leaders for Brain Health group to guide a responsive research program and culturally tailored outreach to Madison’s Black community. Specific Aim 2: Provide educational events in Black churches and community centers located “across the isthmus” of the Madison metropolitan area. Specific Aim 3: Respond to requests from members of the Black Leaders for Brain Health. For example, we want to be prepared to provide training on scientific design, human subject regulations, the ATN criteria as they prioritize the community’s needs and interests. In brief, we seek funding for two years of support for two community-led collaborations directed toward several new initiatives, through which we will support community based participatory research | Role can be determined based on student's skill set and interest | Can be determined through discussion with mentor | Ability to connect to African American and/or American Indian Communities | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | 1) Gleason CE, Norton D, Zuelsdorff M, Benton SF, Wyman MF, Nystrom N, Lambrou N, Salazar H, Koscik RL, Jonaitis E, Carter F, Harris B, Gee A, Chin N, Ketchum F, Johnson SC, Edwards DF, Carlsson CM, Kukull W, Asthana S.Association between enrollment factors and incident cognitive impairment in Blacks and Whites: Data from the Alzheimer's Disease Centers.Alzheimers Dement.2019Oct 6;.doi: 10.1016/j.jalz.2019.07.015.[Epub ahead of print]PMCID: In Process. 2) Clark LR, Zuelsdorff M, Norton D, Johnson SC, Wyman MF, Hancock LM, Carlsson CM, Asthana S, Benton SF, Gleason CE, and Johnson HM. (HMJ and CEG were co-senior authors). Associationof Cardiovascular Risk Factors and Cerebral Profusion in Whites and African Americans. Journal of Alzheimer’s Disease.In Press. 3) Clark LR, Norton D, Berman SE, Johnson SC, Bendlin BB, Wieben O, Turski P, Carlsson C, Asthana, Gleason CE, and Johnson HM. (co-senior author with HMJ). Association of Cardiovascular and Alzheimer’s Disease Risk Factors with Intracranial Aterial Blood Flow in Whites and African Americans. Journal of Alzheimer’s Disease72(3): 919-929. 2019PMCID: In Process. 4) Wyman MF, JonaitisEM, Ward EC, Zuelsdorff M, Gleason CE.Depressive Role Impairment and Subthreshold Depression in Older Black and White Women: Race Differences in the Clinical Significance Criterion. International Psychogeriatrics Aug 28;1-13.2019NIHMSID:NIHMS1534974.PMCID: In Process. 5) Beeri MS, Lin HM, Sano M, Ravona-Springer R, Liu X, Bendlin BB, Gleason CE, Guerrero-Berroa E, Soleimani L, Launer L, Ehrenberg S, Lache O, Seligman YK, Levy AP. Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes: Findings From the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Study. JAMA Network1(7): e184458, 2018PMCID: PMC6324406. 6) Gleason CE, Dowling NM, Benton SF, Kaseroff A, Gunn W, Edwards DF. Common Sense Model Factors Affecting African Americans' Willingness to Consult a Healthcare Provider Regarding Symptoms of Mild Cognitive Impairment. American Journal of Geriatric Psychiatry24: 537-46, 2016. PMCID: PMC4791203. | Yes | Hector Salazar: hsalazar@medicine.wisc.edu; Toni Hofhine: thofhine@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucazB7blns02bwLqIGVb5lkDfXi_WU6TLVtxCC7MfmddeX8dSkJ4r2aa39yQCAMaNs | ||||||
| 04/02/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | Assessment of in-hospital pain control after delivery and its correlation with anxiety in the immediate and long-term postpartum period (obstetrics, pain, opioids, anxiety): While postpartum depression has become increasingly screened for, postpartum anxiety has not been as widely studied, despite a higher estimated incidence between 24.9-28.9%. Further characterization is needed about maternal perspectives on pain control postpartum with the implications that inadequate control has on emotional recovery, physical recovery, and maternal mental health. The aim of this study is to identify the role of post-delivery pain control in the development of postpartum anxiety by using surveys that are specific to the postpartum period. The survey at time of discharge will include a modification of the GAD-7 questionnaire and American Pain Society Patient Outcome Questionnaire (APSPOQ) while the survey at 6 weeks will be the GAD-7. The student would have the opportunity to be the first author on an abstract submitted to a national OB/GYN meeting (ACOG) and could present the poster there in May of 2021. The student would also have the opportunity to be first author on the manuscript of discharge survey data and, if desired, the 6 week postpartum survey data. IRB is approved and the project is ready to start. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM ____________________________________________________________________________ Role - The student’s roles here would include (1) approaching women admitted to the postpartum floor and requesting permission from the women (via signature and email address being recorded on a form) to have a survey emailed to them about anxiety, (2) entering the email address into REDCap to send the survey (the follow-up survey will automatically send), and (3) enter clinical data about the postpartum women into the REDCap database. During the summer Shapiro rotation, discharge survey data would become available and would be able to be analyzed during the summer for submission to a national OB/GYN meeting with an October 2020 deadline. ; IRB Status - Approved. UPH-Meriter IRB 2019-016; Skills - Data entry into online database | 0 | kantony@wisc.edu | Kathleen | Antony | M.D., M.S.C.I. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: | Assistant Professor | 6.084.176.099 | Maternal-Fetal Medicine | Assessment of in-hospital pain control after delivery and its correlation with anxiety in the immediate and long-term postpartum period (obstetrics, pain, opioids, anxiety) | While postpartum depression has become increasingly screened for, postpartum anxiety has not been as widely studied, despite a higher estimated incidence between 24.9-28.9%. Further characterization is needed about maternal perspectives on pain control postpartum with the implications that inadequate control has on emotional recovery, physical recovery, and maternal mental health. The aim of this study is to identify the role of post-delivery pain control in the development of postpartum anxiety by using surveys that are specific to the postpartum period. The survey at time of discharge will include a modification of the GAD-7 questionnaire and American Pain Society Patient Outcome Questionnaire (APSPOQ) while the survey at 6 weeks will be the GAD-7. The student would have the opportunity to be the first author on an abstract submitted to a national OB/GYN meeting (ACOG) and could present the poster there in May of 2021. The student would also have the opportunity to be first author on the manuscript of discharge survey data and, if desired, the 6 week postpartum survey data. IRB is approved and the project is ready to start. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM | The student’s roles here would include (1) approaching women admitted to the postpartum floor and requesting permission from the women (via signature and email address being recorded on a form) to have a survey emailed to them about anxiety, (2) entering the email address into REDCap to send the survey (the follow-up survey will automatically send), and (3) enter clinical data about the postpartum women into the REDCap database. During the summer Shapiro rotation, discharge survey data would become available and would be able to be analyzed during the summer for submission to a national OB/GYN meeting with an October 2020 deadline. | Would ideally feel comfortable talking to patients (postpartum women) and entering data into REDCap (can be taught) | Data entry into online database | Approved. UPH-Meriter IRB 2019-016 | No | No funding. | Yes | UW undergraduates interested in research | A pilot randomized controlled trial of Lidocaine patches for post Cesarean pain control among women with obesity. Kathleen M. ANTONY1, Scott HETZEL2, Laura JACQUES3, Jacquelyn H. ADAMS1, Amye TEVAARWERK4 (Manuscript in preparation). | Yes | Ian Bird imbird@wisc.edu, Lauren Suchla lpuglisi@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufPSzFvTok4sAgO8qQcVCvmnTzMoNcaRsB3IT3E4aMyCVvBs1sDoonvKD3RsXwGrGg | ||||||
| 03/02/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | Subcutaneous injection of bupivacaine at the Cesarean incision site and post-Cesarean opioid use (obstetrics, opioid, local anesthetics, pain): This would be a retrospective study investigating the impact of local anesthestics injected at the site of the Cesarean incision on the total dose of opioids used for pain control in the first 24-48 hours postpartum. Status: IRB is not yet done, but if there were interest in the project, the IRB would be applied for. The mentor already has existing databases of women who underwent Cesarean deliveries at Meriter from 2016-March 2019, including data on the total dose of opioids used. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM ____________________________________________________________________________ Role - The student’s role would be to assist with data extraction/ chart review. The outcome for the student would be a first authorship. The primary and secondary goals would be to (1) submit an abstract to a national meeting by the first week of August (which is the deadline for one of the OB/GYN national meetings), (2) to author a first draft of a manuscript (either during the summer or throughout the student’s second year, depending upon availability to write), and (3) publish such a manuscript sometime prior to applying for residency. ; IRB Status - Not yet applied but would secondarily use data from two other IRBs (after approved). ; Skills - Familiarity with finding data in the electronic health record (Epic), possibility of learning statistics via STATA if desired | 0 | kantony@wisc.edu | Kathleen | Antony | M.D., M.S.C.I. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: | Assistant Professor | 6.084.176.099 | Maternal-Fetal Medicine | Subcutaneous injection of bupivacaine at the Cesarean incision site and post-Cesarean opioid use (obstetrics, opioid, local anesthetics, pain) | This would be a retrospective study investigating the impact of local anesthestics injected at the site of the Cesarean incision on the total dose of opioids used for pain control in the first 24-48 hours postpartum. Status: IRB is not yet done, but if there were interest in the project, the IRB would be applied for. The mentor already has existing databases of women who underwent Cesarean deliveries at Meriter from 2016-March 2019, including data on the total dose of opioids used. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM | The student’s role would be to assist with data extraction/ chart review. The outcome for the student would be a first authorship. The primary and secondary goals would be to (1) submit an abstract to a national meeting by the first week of August (which is the deadline for one of the OB/GYN national meetings), (2) to author a first draft of a manuscript (either during the summer or throughout the student’s second year, depending upon availability to write), and (3) publish such a manuscript sometime prior to applying for residency. | Familiarity with finding data in the electronic health record (Epic), possibility of learning statistics via STATA if desired. I will provide weekly mentor meetings and more frequent as needed. | Familiarity with finding data in the electronic health record (Epic), possibility of learning statistics via STATA if desired | Not yet applied but would secondarily use data from two other IRBs (after approved). | No | No funding. | Yes | UW undergraduates interested in research | A pilot randomized controlled trial of Lidocaine patches for post Cesarean pain control among women with obesity. Kathleen M. ANTONY1, Scott HETZEL2, Laura JACQUES3, Jacquelyn H. ADAMS1, Amye TEVAARWERK4. (Manuscript in preparation) | Yes | Ian Bird imbird@wisc.edu and Lauren Suchla lpuglisi@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuepe-CMeZoZVG1Nge2T7oXTX5yF5BNReqOdNK1M8IEHnidr1-HHbhAT5_0gjUd5Otg | ||||||
| 03/02/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | Various opioid, obesity, and obstetric topics: I have previously done a retrospective study investigating the impact of obesity and opioids on respiratory compromise in women who have undergone Cesarean delivery. I would be happy to mentor a student-inspired project related to obesity, opioid use, or respiratory compromise, and I have an existing database. (If this project is chosen, we would meet ahead of time to clarify question and to submit the IRB amendment so everything is ready to go when you start.) The role here is that the medical student would provide the hypothesis/ research question and would also serve as first author on abstracts submitted. Our national meeting has an abstract submission deadline in early August, so submission would be a goal. Another meeting has an October deadline, so that could serve as a backup. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM ____________________________________________________________________________ Role - The student's role could include anything from data extraction to data analysis, depending upon the exact project chosen. The student would also have the ability to first author abstracts for national meetings and also manuscripts depending upon motivation and interest. ; IRB Status - Depending upon the project, this would likely require modification of an existing IRB or may be already included within the aims of existing IRBs. We would discuss the specific topic. ; Skills - Familiarity with REDCap and excel is helpful but can also be taught. | 0 | kantony@wisc.edu | Kathleen | Antony | M.D., M.S.C.I. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: | Assistant Professor | 6.084.176.099 | Maternal-Fetal Medicine | Various opioid, obesity, and obstetric topics | I have previously done a retrospective study investigating the impact of obesity and opioids on respiratory compromise in women who have undergone Cesarean delivery. I would be happy to mentor a student-inspired project related to obesity, opioid use, or respiratory compromise, and I have an existing database. (If this project is chosen, we would meet ahead of time to clarify question and to submit the IRB amendment so everything is ready to go when you start.) The role here is that the medical student would provide the hypothesis/ research question and would also serve as first author on abstracts submitted. Our national meeting has an abstract submission deadline in early August, so submission would be a goal. Another meeting has an October deadline, so that could serve as a backup. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM | The student's role could include anything from data extraction to data analysis, depending upon the exact project chosen. The student would also have the ability to first author abstracts for national meetings and also manuscripts depending upon motivation and interest. | Varies. | Familiarity with REDCap and excel is helpful but can also be taught. | Depending upon the project, this would likely require modification of an existing IRB or may be already included within the aims of existing IRBs. We would discuss the specific topic. | No | No. | Yes | UW undergraduates interested in research | A pilot randomized controlled trial of Lidocaine patches for post Cesarean pain control among women with obesity. Kathleen M. ANTONY1, Scott HETZEL2, Laura JACQUES3, Jacquelyn H. ADAMS1, Amye TEVAARWERK4. (Manuscript in preparation.) *Gupta V, Adams J, Heiser T, Iruregatoyena JI, Hoppe KK, Antony KM. Detailed Fetal Anatomic Ultrasound Examination Duration and Association With Body Mass Index. Obstetrics and Gynecology. 2019 Oct; 134(4):774-780 Craemer KA, Sampene E, Safdar N, Antony KM, Wautlet CK, “Nutrition and Exercise Strategies to Prevent Excessive Pregnancy Weight Gain: A Meta-analysis” American Journal of Perinatology Reports. 2019 Jan; 9(1):e92-e120. Gordon G, Antony KM, Sampene E, Irugetagoyena, J. “Maternal Obesity is Not Associated with Increased Crown-Rump Length in First-Trimester Ultrasounds of Singleton Gestations.” The Journal of Maternal-Fetal & Neonatal Medicine. 2018 Feb 20:1-7. Chu DM, Antony KM, Ma J, Prince AL, Showalter L, Moller M, Aagaard KM. “The early infant gut microbiome varies in association with a maternal high-fat diet.” Genome Medicine. 2016 Aug 9; 8(1):77. PMID: 27503374 Kahr MK, Antony KM, DelBeccaro M, Hu M, Aagaard KM, Suter MA. “Increasing Maternal Obesity is Associated with Alterations in both Maternal and Neonatal Thyroid Hormone Levels.” Clinical Endocrinology. 2016 Apr;84(4):551-7. PMID: 26562744 Antony KM, Ma J, Mitchell KB, Racusin DA, Versalovic J, Aagaard K. “The Preterm Placental Microbiome Varies in Association with Excess Maternal Gestational Weight Gain.” American Journal of Obstetrics and Gynecology. 2015 May; 212(5):653.e1-16. PMID: 25557210 | Yes | Ian Bird imbird@wisc.edu and Lauren Suchla lpuglisi@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue-WrcapNZYqS4fZrerXOZkkqEOFT9HcWZvLVaFH8EMfkv6meqyAernHz4zEm4PtvI | ||||||
| 30/01/2020 | Academic Affairs | Not currently interested or available for Non-Shapiro research mentoring of medical students | Medical Students as Teachers Training Program: A close examination of national programs that train medical students to become teachers. This project includes an initial literature review to assess the national landscape. The primary goal of the project is to create, disseminate and analyze results of a national survey that will identify the benefits and barriers to students as teachers training programs as well as current formats and structure. Identified best practices can then be translated into an internal program at SMPH. ____________________________________________________________________________ Role - Student will receive specific instructions and develop clear goals and timelines with the mentors. Primarily will be working with library contact to perform comprehensive literature search. Also survey development and analyzing results of data collected. ; IRB Status - N/A; Skills - Experience with surveys and data analysis would be a plus. | 0 | aebecker@wisc.edu | Amy | Stickford Becker | MA | Amy Stickford Becker, aebecker@wisc.edu -- Co-Mentor: Shobhina Chheda | Director of Longitudinal Curriculum and Instruction | 265 | Medical Education Office | Shobhina | Chheda | Medicine | Medical Students as Teachers Training Program | A close examination of national programs that train medical students to become teachers. This project includes an initial literature review to assess the national landscape. The primary goal of the project is to create, disseminate and analyze results of a national survey that will identify the benefits and barriers to students as teachers training programs as well as current formats and structure. Identified best practices can then be translated into an internal program at SMPH. | Student will receive specific instructions and develop clear goals and timelines with the mentors. Primarily will be working with library contact to perform comprehensive literature search. Also survey development and analyzing results of data collected. | Student must be able to work independently on a day-to-day basis, but will have full access to and regular check-in time with the mentors. | Experience with surveys and data analysis would be a plus. | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | n/a | Yes | n/a | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufB-bUMh9ai7D5AwNO-h1quLTeTfqS1Pv4ja71tK00tNNU8d2jmKXYXt8MYVjhdNrg | |||
| 31/01/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | The impact of penicillin allergy on risk for surgical site infection in Cesarean deliveries (obstetrics, infectious disease, surgical site infection): Penicillin allergy is reported in 10-20% of the population, and most patients reporting penicillin allergy receive second-line surgical site infection prophylaxis, which are typically less effective. Cesarean delivery is the second most common surgical procedure in the United States, and carries a high risk of surgical site infection. However, no prior published studies have queried whether penicillin allergy increases this risk. This project would be a retrospective chart review of women undergoing Cesarean delivery at Meriter hospital. The presence or absence of a penicillin allergy (exposure) would be noted, as would the severity of the allergy and the pre-operative antibiotics received. The outcome would be the incidence of surgical site infection. This project is not yet IRB approved. However, it would draw upon existing datasets of women who underwent Cesarean delivery at Meriter (which I already have from other ongoing projects), and would be eligible for an amendment of an existing IRB if a student chose this project. ____________________________________________________________________________ Role - The student’s role would be to: 1. Perform the chart review via Epic (both Meriter and UW, as many prenatal records are in the UW system) 2. Work with the statistician to perform the analysis (or work to learn STATA to perform this analysis themselves, including the adjusted analysis to control for confounding variables, such as BMI) 3. Prepare and abstract for submission to a national meeting. Two deadlines for OB national meetings are in early August with another option in early October 4. Prepare a manuscript (if motivated and interested) with a potential for first authorship if the student writes the manuscript. Because this has not been published yet and Cesareans are very common, this has the potential to get into a “bigger” OB/GYN journal, but there is no guarantee. ; IRB Status - This project is not yet IRB approved. However, it would draw upon existing datasets of women who underwent Cesarean delivery at Meriter (which I already have from other ongoing projects), and would be eligible for an amendment of an existing IRB if a student chose this project. ; Skills - Ability to use Epic (UW and Meriter) and Excel (for data collection). If desired, student could also learn STATA for analysis | 0 | kantony@wisc.edu | Kathleen | Antony | M.D., M.S.C.I. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: Daniel Shirley dshirley@medicine.wisc.edu | Assistant Professor | 6.084.176.099 | Maternal-Fetal Medicine | Daniel Shirley | dshirley@medicine.wisc.edu | Medicine | Infectious Disease | The impact of penicillin allergy on risk for surgical site infection in Cesarean deliveries (obstetrics, infectious disease, surgical site infection) | Penicillin allergy is reported in 10-20% of the population, and most patients reporting penicillin allergy receive second-line surgical site infection prophylaxis, which are typically less effective. Cesarean delivery is the second most common surgical procedure in the United States, and carries a high risk of surgical site infection. However, no prior published studies have queried whether penicillin allergy increases this risk. This project would be a retrospective chart review of women undergoing Cesarean delivery at Meriter hospital. The presence or absence of a penicillin allergy (exposure) would be noted, as would the severity of the allergy and the pre-operative antibiotics received. The outcome would be the incidence of surgical site infection. This project is not yet IRB approved. However, it would draw upon existing datasets of women who underwent Cesarean delivery at Meriter (which I already have from other ongoing projects), and would be eligible for an amendment of an existing IRB if a student chose this project. | The student’s role would be to: 1. Perform the chart review via Epic (both Meriter and UW, as many prenatal records are in the UW system) 2. Work with the statistician to perform the analysis (or work to learn STATA to perform this analysis themselves, including the adjusted analysis to control for confounding variables, such as BMI) 3. Prepare and abstract for submission to a national meeting. Two deadlines for OB national meetings are in early August with another option in early October 4. Prepare a manuscript (if motivated and interested) with a potential for first authorship if the student writes the manuscript. Because this has not been published yet and Cesareans are very common, this has the potential to get into a “bigger” OB/GYN journal, but there is no guarantee. | This would require chart review and ability to review electronic health record independently (after orientation) | Ability to use Epic (UW and Meriter) and Excel (for data collection). If desired, student could also learn STATA for analysis | This project is not yet IRB approved. However, it would draw upon existing datasets of women who underwent Cesarean delivery at Meriter (which I already have from other ongoing projects), and would be eligible for an amendment of an existing IRB if a student chose this project. | No | No | Yes | UW undergraduates interested in research | Prince AL, Chu DM, Seferovic MD, Antony KM, Ma J, Aagaard. “The Perinatal Microbiome and Pregnancy: Moving Beyond the Vaginal Microbiome.” Cold Spring Harbor Perspectives in Medicine. 2015 Mar 16; (5)6. PMID: 25775922. Antony KM, Ma J, Mitchell KB, Racusin DA, Versalovic J, Aagaard K. “The Preterm Placental Microbiome Varies in Association with Excess Maternal Gestational Weight Gain.” American Journal of Obstetrics and Gynecology. 2015 May; 212(5):653.e1-16. PMID: 25557210 Chu DM, Antony KM, Ma J, Prince AL, Showalter L, Moller M, Aagaard KM. “The early infant gut microbiome varies in association with a maternal high-fat diet.” Genome Medicine. 2016 Aug 9; 8(1):77. PMID: 27503374 Chu D, Ma J, Prince A, Antony K, Seferovic M, Aagaard K. “Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery.” Nature Medicine. 2017 Mar;23(3):314-326. PMID: 28112736 | Yes | Ian Bird imbird@wisc.edu and Lauren Suchla lpuglisi@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue55p88ED5EDPw8ufKWGObYlulrqvXW2njVoALJYzCwt7kmBN-NhTLbNVS873YCgQo | ||
| 23/01/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | Qualitative Obstetric Obesity Survey : The purpose of this project is to interview women with obesity about their perspectives, preferences, and experiences with prenatal care, query preferred terminology regarding obesity, and also to seek input on potential programs that could be developed to facilitate a healthy pregnancy. This will be achieved via a qualitative assessment comprised of a scripted telephone interview. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM ____________________________________________________________________________ Role - The student’s role here would be to: 1-Use existing lists of current and past patients receiving prenatal care at the Meriter Center for Perinatal Care (UW’s high risk pregnancy clinic) to identify patients with obesity who have delivered a baby in the past 18-24 months. 2-Perform a brief chart review of the obstetric discharge summary to ensure that calling the patient is low-risk and unlikely to trigger a significant stress response. 3-Call the most recent telephone number and request permission to interview about experiences. 4-The telephone call will be recorded. This recording will be used to type a transcript which will be reviewed by obstetric care providers (the PI) to improve the clinical experience of pregnant women with obesity 5-These results would be eligible to be written up and reported upon in an abstract submitted to local and national meetings and a manuscript would be eligible for publication, likely in a smaller (lower impact but PubMed cited) journal. Abstract deadline would be either early August or early October (two potential meetings) 6- The student would have the opportunity to be first author on abstracts and potentially a manuscript if the student writes the first draft and is available for editing. (Deadline at the student’s convenience, but would be of student’s interest to finish prior to clinical rotations due to time constraints); IRB Status - This project was approved for IRB-waiver as the primary goal is to improve clinical care. This project is ready to start once a student is available and trained (ie: Epic training at UPH-Meriter, HIPPAA training); Skills - Epic, ability to transcribe/ type transcript. | 0 | kantony@wisc.edu | Kathleen | Antony | M.D., M.S.C.I. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: | Assistant Professor | 6.084.176.099 | Maternal-Fetal Medicine | Qualitative Obstetric Obesity Survey | The purpose of this project is to interview women with obesity about their perspectives, preferences, and experiences with prenatal care, query preferred terminology regarding obesity, and also to seek input on potential programs that could be developed to facilitate a healthy pregnancy. This will be achieved via a qualitative assessment comprised of a scripted telephone interview. I am happy to discuss other ideas generated by medical students. (Email kantony@wisc.edu ) PubMed Author Name: Antony KM | The student’s role here would be to: 1-Use existing lists of current and past patients receiving prenatal care at the Meriter Center for Perinatal Care (UW’s high risk pregnancy clinic) to identify patients with obesity who have delivered a baby in the past 18-24 months. 2-Perform a brief chart review of the obstetric discharge summary to ensure that calling the patient is low-risk and unlikely to trigger a significant stress response. 3-Call the most recent telephone number and request permission to interview about experiences. 4-The telephone call will be recorded. This recording will be used to type a transcript which will be reviewed by obstetric care providers (the PI) to improve the clinical experience of pregnant women with obesity 5-These results would be eligible to be written up and reported upon in an abstract submitted to local and national meetings and a manuscript would be eligible for publication, likely in a smaller (lower impact but PubMed cited) journal. Abstract deadline would be either early August or early October (two potential meetings) 6- The student would have the opportunity to be first author on abstracts and potentially a manuscript if the student writes the first draft and is available for editing. (Deadline at the student’s convenience, but would be of student’s interest to finish prior to clinical rotations due to time constraints) | Comfort with talking to former patients on the telephone and perform chart review. | Epic, ability to transcribe/ type transcript. | This project was approved for IRB-waiver as the primary goal is to improve clinical care. This project is ready to start once a student is available and trained (ie: Epic training at UPH-Meriter, HIPPAA training) | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | Antony KM, Ma J, Mitchell KB, Racusin DA, Versalovic J, Aagaard K. “The Preterm Placental Microbiome Varies in Association with Excess Maternal Gestational Weight Gain.” American Journal of Obstetrics and Gynecology. 2015 May; 212(5):653.e1-16. PMID: 25557210 Kahr MK, Antony KM, DelBeccaro M, Hu M, Aagaard KM, Suter MA. “Increasing Maternal Obesity is Associated with Alterations in both Maternal and Neonatal Thyroid Hormone Levels.” Clinical Endocrinology. 2016 Apr;84(4):551-7. PMID: 26562744 Gordon G, Antony KM, Sampene E, Irugetagoyena, J. “Maternal Obesity is Not Associated with Increased Crown-Rump Length in First-Trimester Ultrasounds of Singleton Gestations.” The Journal of Maternal-Fetal & Neonatal Medicine. 2018 Feb 20:1-7. doi: 10.1080/14767058.2018.1438396. Craemer KA, Sampene E, Safdar N, Antony KM, Wautlet CK, “Nutrition and Exercise Strategies to Prevent Excessive Pregnancy Weight Gain: A Meta-analysis” American Journal of Perinatology Reports. 2019 Jan; 9(1):e92-e120. doi 10.1055/s-0039-1683377 Gupta V, Adams J, Heiser T, Iruregatoyena JI, Hoppe KK, Antony KM. Detailed Fetal Anatomic Ultrasound Examination Duration and Association With Body Mass Index. Obstetrics and Gynecology. 2019 Oct; 134(4):774-780. doi: 10.1097/AOG.0000000000003489. PMID: 31503163 | Yes | Ian Bird imbird@wisc.edu and Lauren Suchla lpuglisi@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufVwfIK43pA8ujNYn1jNsbxsFEHWUwnmm05FTe3CY5i0NZsZlHXF9650DmjhL0P2og | ||||||
| 15/01/2020 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Pre-participation Evaluation: Two possible projects involving PPE used by primary care providers screening athletes for participation in sports ____________________________________________________________________________ Role - IRB approval, survey development, survey administration, collate results and present if wanted; IRB Status - pending; Skills - passionate about sports medicine | 1 | david.bernhardt@wisc.edu | David | Bernhardt | MD | David Bernhardt, david.bernhardt@wisc.edu -- Co-Mentor: | Professor, Department of Pediatrics and Orthopedics, Division of Sports Medicine | 608 | Sports Medicine/General Peds | Orthopedics and Rehabilitation | sports medicine | Pre-participation Evaluation | Two possible projects involving PPE used by primary care providers screening athletes for participation in sports | IRB approval, survey development, survey administration, collate results and present if wanted | significant | passionate about sports medicine | pending | No | to be determined | Yes | Not currently available to mentor other students | none - coeditor of a monograph directly related to this project | No | Megan Moreno; Heidi Abelinger | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuerju-v5AJNkYJIrj6LePdLiTz_q9dS4m06JSlfBpL50K0M0QnSbdAAebGOWWBdkvU | ||||
| 15/01/2020 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | A Novel Technique for Kidney Volume Assessment and Prognostication in ADPKD.: We will investigate investigate role of novel radiologic markers such as non-cystic kidney volume in prognostication in polycystic kidney disease. We will utilize retrospective cohort of ADPKD patients at UW and perhaps from CRISP cohort or the Mayo PKD center for external validation ____________________________________________________________________________ Role - Evaluating the images for total kidney volume and non-cystic volume using 3D technique and then correlating this with renal function trends on the cohort ; IRB Status - approved; Skills - Will train student | 1 | gbhutani@medicine.wisc.edu | Gauri | Bhutani | MBBS | Gauri Bhutani, gbhutani@medicine.wisc.edu -- Co-Mentor: Lori Mankowski Gettle LMankowskiGettle@uwhealth.org | Clinical Assistant Professor | 5.015.514.815 | Nephrology | Lori Mankowski Gettle | LMankowskiGettle@uwhealth.org | Radiology | A Novel Technique for Kidney Volume Assessment and Prognostication in ADPKD. | We will investigate investigate role of novel radiologic markers such as non-cystic kidney volume in prognostication in polycystic kidney disease. We will utilize retrospective cohort of ADPKD patients at UW and perhaps from CRISP cohort or the Mayo PKD center for external validation | Evaluating the images for total kidney volume and non-cystic volume using 3D technique and then correlating this with renal function trends on the cohort | Will train student | approved | No | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | 1. Imaging Classification of Autosomal Dominant Polycystic Kidney Disease: A Simple Model for Selecting Patients for Clinical Trials - Irazabal, MV et al - Journal of American Society of Nephrology 2015 2. A Review of the Imaging Techniques for Measuring Kidney and Cyst Volume in Establishing Autosomal Dominant Polycystic Kidney Disease Progression - Magistroni, R et al - American Journal of Nephrology 2018 3. Automatic total kidney volume measurement on follow-up magnetic resonance images to facilitate monitoring of autosomal dominant polycystic kidney disease progression - Kline, TL - Nephrol Dial Transplant 2016 4. A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease - Bhutani, H - Kidney International 2016 5. Tolvaptan in the treatment of autosomal dominant polycystic kidney disease: patient selection and special considerations - Sans-Atxer, L et al - Int Journal of Nephrology and Renovascular Disease 2018 | No | NA | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufcm1kX0yKc-QtzXprkMy8ILo20nLyEpHYWZmUn0iYw-nIw3ksrELLCg-Xsc00VhhY | ||||
| 15/01/2020 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Renal Outcomes and Prognostic Factors in patients on Immunotherapy: Immunotherapy is a recent treatment being utilized for treatment of advanced renal cell cancer and lung cancer amongst others. Immune mediated nephritis from use of these agents is well described. We do not know the incidence and outcomes from this complication at our center. We also do not know incidence and impact chronic kidney disease as a result of immunotherapy related kidney complications. In addition, optimal treatment and whom to rechallenge with immunotherapy including timing of these interventions is not well understood. ____________________________________________________________________________ Role - Chart review and working with EPIC to extract data; analyze data with help of statisitician. write manuscript; IRB Status - Pending; Skills - will train | 1 | gbhutani@medicine.wisc.edu | Gauri | Bhutani | MBBS | Gauri Bhutani, gbhutani@medicine.wisc.edu -- Co-Mentor: Ticiana Leal tbleal@medicine.wisc.edu | Clinical Assistant Professor | 5.015.514.815 | Nephrology | Ticiana Leal | tbleal@medicine.wisc.edu | Medicine | Hematology & Oncology | Renal Outcomes and Prognostic Factors in patients on Immunotherapy | Immunotherapy is a recent treatment being utilized for treatment of advanced renal cell cancer and lung cancer amongst others. Immune mediated nephritis from use of these agents is well described. We do not know the incidence and outcomes from this complication at our center. We also do not know incidence and impact chronic kidney disease as a result of immunotherapy related kidney complications. In addition, optimal treatment and whom to rechallenge with immunotherapy including timing of these interventions is not well understood. | Chart review and working with EPIC to extract data; analyze data with help of statisitician. write manuscript | will train | Pending | No | Yes | Yes | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | 1. The nephrotoxicity of immune checkpoint inhibitor based combinations - Elie El Rassy et al - European Journal of CanceR 2018 2. Renal impairment during pemetrexed maintenance in patients with advanced nonsmall cell lung cancer: a cohort study - Sabine Visser et al - Eur Respir J 2018 3. Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review - Rimda Wanchoo et al - Am J of Neph 2017 | No | NA | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucpnu9-T2gnp9vcPfmjQ2SjSTMCD7uVzmVgEpT4CMXC1UgGyPu_t3NtjWpbXN4WGO0 | |||
| 15/01/2020 | Orthopedics and Rehabilitation | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Validation of measurement bone mineral density of distal femur: We have enrolled 100 patients in a study to evaluate bone mineral density along the length of the femur in patients having knee replacement. Currently only the proximal femur is used to asses bone health for osteoporosis. However, bone density of the distal femur is important in these patients having total knee replacement. This would help surgeons plan surgery, advise patients to have preoperative bone health optimization, and detect longitudinal changes over time that may lead to fracture or failure. The aims of the project are to determine inter and intraobserver reliability of measurement of bone mineral density, correlate the distal femur bone density to the proximal femur and lumbar spine, and to validate measurements methods using phantoms. ____________________________________________________________________________ Role - The student role would be to measure bone mineral density (BMD) from existing DXA scans of the distal femur, hip, lumbar spine and distal radius in 100 patients who have been enrolled in a prior study. Two other personal would also perform measurement so that intra and interobserver reliability can be determined. Further, statistical correlation between distal femur BMD and the standard sites to measure BMD (hip, lumbar spine and radius) will be performed. The student would validate the BMD measurement techniques using phantoms or cadavers. Finally working with engineer a method to automate BMD analysis of the distal femur will be attempted. ; IRB Status - The study is already IRB approved. The student will need CITI training to be added to IRB.; Skills - NO specific skills. | 0 | anderson@ortho.wisc.edu | Paul | Anderson | MD | Paul Anderson, anderson@ortho.wisc.edu -- Co-Mentor: Neil Binkley MD nbinkley@wisc.edu | Professor Orthopedic surgery | 6.082.634.069 | Other | Osteoporosis | Neil Binkley MD | nbinkley@wisc.edu | Medicine | Osteoporosis | Validation of measurement bone mineral density of distal femur | We have enrolled 100 patients in a study to evaluate bone mineral density along the length of the femur in patients having knee replacement. Currently only the proximal femur is used to asses bone health for osteoporosis. However, bone density of the distal femur is important in these patients having total knee replacement. This would help surgeons plan surgery, advise patients to have preoperative bone health optimization, and detect longitudinal changes over time that may lead to fracture or failure. The aims of the project are to determine inter and intraobserver reliability of measurement of bone mineral density, correlate the distal femur bone density to the proximal femur and lumbar spine, and to validate measurements methods using phantoms. | The student role would be to measure bone mineral density (BMD) from existing DXA scans of the distal femur, hip, lumbar spine and distal radius in 100 patients who have been enrolled in a prior study. Two other personal would also perform measurement so that intra and interobserver reliability can be determined. Further, statistical correlation between distal femur BMD and the standard sites to measure BMD (hip, lumbar spine and radius) will be performed. The student would validate the BMD measurement techniques using phantoms or cadavers. Finally working with engineer a method to automate BMD analysis of the distal femur will be attempted. | The DXA methid to masure BMD is staright forwrad so that the student can work independently quickly. Statistical support will be available through ICRT and faculty mentoring.. | NO specific skills. | The study is already IRB approved. The student will need CITI training to be added to IRB. | No | Yes | Yes | PhD students | Anderson PA, Morgan SL, Krueger D, Zapalowski C, Tanner B, Jeray KJ, Krohn KD, Lane JP, Yeap SS, Shuhart CR, Shepherd J. Use of Bone Health Evaluation in Orthopedic Surgery: 2019 ISCD Official Position. J Clin Densitom. 2019 Oct - Dec;22(4):517-543. doi: 10.1016/j.jocd.2019.07.013. Epub 2019 Aug 16. PubMed PMID: 31519473. 2: Anderson PA, Jeray KJ, Lane JM, Binkley NC. Bone Health Optimization: Beyond Own the Bone: AOA Critical Issues. J Bone Joint Surg Am. 2019 Aug 7;101(15):1413-1419. doi: 10.2106/JBJS.18.01229. PubMed PMID: 31393435. 3: Bernatz JT, Krueger DC, Squire MW, Illgen RL 2nd, Binkley NC, Anderson PA. Unrecognized Osteoporosis Is Common in Patients With a Well-Functioning Total Knee Arthroplasty. J Arthroplasty. 2019 Oct;34(10):2347-2350. doi: 10.1016/j.arth.2019.05.041. Epub 2019 May 30. PubMed PMID: 31227302. 4: Bernatz JT, Brooks AE, Squire MW, Illgen RI 2nd, Binkley NC, Anderson PA. Osteoporosis Is Common and Undertreated Prior to Total Joint Arthroplasty. J Arthroplasty. 2019 Jul;34(7):1347-1353. doi: 10.1016/j.arth.2019.03.044. Epub 2019 Mar 28. PubMed PMID: 30992237. 5: Prince JM, Bernatz JT, Binkley N, Abdel MP, Anderson PA. Changes in femoral bone mineral density after total knee arthroplasty: a systematic review and meta-analysis. Arch Osteoporos. 2019 Feb 23;14(1):23. doi: 10.1007/s11657-019-0572-7. Review. PubMed PMID: 30798359. 6: Anderson PA, Polly DW, Binkley NC, Pickhardt PJ. Clinical Use of Opportunistic Computed Tomography Screening for Osteoporosis. J Bone Joint Surg Am. 2018 Dec 5;100(23):2073-2081. doi: 10.2106/JBJS.17.01376. Review. PubMed PMID: 30516631. 7: Thomas B, Binkley N, Anderson PA, Krueger D. DXA Measured Distal Femur Bone Mineral Density in Patients After Total Knee Arthroplasty: Method Development and Reproducibility. J Clin Densitom. 2019 Jan - Mar;22(1):67-73. doi: 10.1016/j.jocd.2018.08.003. Epub 2018 Aug 13. PubMed PMID: 30228047. 8: Carlson BC, Robinson WA, Wanderman NR, Nassr AN, Huddleston PM 3rd, Yaszemski MJ, Currier BL, Jeray KJ, Kirk KL, Bunta AD, Murphy S, Patel B, Watkins CM, Sietsema DL, Edwards BJ, Tosi LL, Anderson PA, Freedman BA. The American Orthopaedic Association's Own the Bone® database: a national quality improvement project for the treatment of bone health in fragility fracture patients. Osteoporos Int. 2018 Sep;29(9):2101-2109. doi: 10.1007/s00198-018-4585-7. Epub 2018 Jun 1. PubMed PMID: 29858634. 9: Hendrickson NR, Pickhardt PJ, Del Rio AM, Rosas HG, Anderson PA. Bone Mineral Density T-Scores Derived from CT Attenuation Numbers (Hounsfield Units): Clinical Utility and Correlation with Dual-energy X-ray Absorptiometry. Iowa Orthop J. 2018;38:25-31. PubMed PMID: 30104921; PubMed Central PMCID: PMC6047377. | Yes | Ableidinger, Heidi |
https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudz5tByj9E1IRSLiLcR01ulvA0y2schleyCE8zdrRfUS-m9XerrBajn2LX-3y_BP2g | |
| 17/01/2020 | Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Reducing Opioid use among patients undergoing colorectal surgery: Reducing opioid use among patients undergoing colorectal surgery ____________________________________________________________________________ Role - Assist in developing dashboard and educational materials, data collection; IRB Status - Approved; Skills - None | 1 | lawson@surgery.wisc.edu | Elise | Lawson | MD, MSHS | Elise Lawson, lawson@surgery.wisc.edu -- Co-Mentor: | Assistant Professor | 608 | Division of Colorectal Surgery | Reducing Opioid use among patients undergoing colorectal surgery | Reducing opioid use among patients undergoing colorectal surgery | Assist in developing dashboard and educational materials, data collection | None | Approved | Department Support for Shapiro Program | Department Support for Shapiro Program | Yes | Not currently available to mentor other students | Will discuss at meeting | No | pavao@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufz0wGEtXYZzNBiT65QmMabSHwk5foXN0pHebIMWwbxJtoCs36FbHcZ3cPIO1xDJQg | |||||||
| 22/01/2020 | Anesthesiology | Shorter term projects | Does dexmedetomidine premedication reduce risk of postoperative behavior changes? : Up to 60% of pediatric patients develop negative behavior changes following surgery, including nightmares, bed wetting, aggression toward authority, irritability, and separation anxiety. These changes can last from a few weeks up to a year! Uncontrolled anxiety has been linked to these maladaptive behaviors. I hypothesize that if we administer intranasal dexmedetomidine, a sedative medication, prior to taking patients to the operating room, their pre-operative anxiety will be controlled and thus reduce the incidence of postoperative negative behavior changes. This will be a prospective study. We will administer the medication vs. placebo pre-op, then send the parents an email containing a link to the Post-Hospital Behavior Questionnaire at 1 day, 1 week, and 1 month following surgery to compare rates of behavior changes. I especially need help reaching out to parents electronically and via phone to ensure good follow up. ____________________________________________________________________________ Role - Contacting parents via email and phone for survey follow-up; IRB Status - I have not yet started the IRB application; Skills - Computer skillz. | 0 | lmvolz@wisc.edu | Lana | Volz | MD | Lana Volz, lmvolz@wisc.edu -- Co-Mentor: | Associate Professor of Anesthesiology | 608 | Pediatric Anesthesiology | Does dexmedetomidine premedication reduce risk of postoperative behavior changes? | Up to 60% of pediatric patients develop negative behavior changes following surgery, including nightmares, bed wetting, aggression toward authority, irritability, and separation anxiety. These changes can last from a few weeks up to a year! Uncontrolled anxiety has been linked to these maladaptive behaviors. I hypothesize that if we administer intranasal dexmedetomidine, a sedative medication, prior to taking patients to the operating room, their pre-operative anxiety will be controlled and thus reduce the incidence of postoperative negative behavior changes. This will be a prospective study. We will administer the medication vs. placebo pre-op, then send the parents an email containing a link to the Post-Hospital Behavior Questionnaire at 1 day, 1 week, and 1 month following surgery to compare rates of behavior changes. I especially need help reaching out to parents electronically and via phone to ensure good follow up. | Contacting parents via email and phone for survey follow-up | Moderate | Computer skillz. | I have not yet started the IRB application | No | Unsure. Department of Anesthesiology support. | Yes | MPH students, UW undergraduates interested in research | Drug Design, Development and Therapy 2019:13 897–905 This review article presents a good overview of the problem. | Yes | Dr. McQueen, Chair (via Marie Hendricks, her assistant: Marie.hendricks@wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueCUoA0SJ5TVjPGI4ftMKhySF8MzXglFHg3fwKr6FAvnxucOviGcOSdevgvCy1-vkI | ||||||
| 23/01/2020 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Use of anticoagulation and outcomes in Lupus Nephritis with thrombotic microangiopathy: The goal of the project is to look at outcomes of patients with lupus nephritis and thrombotic microangiopathy and see if any oral anticoagulation including ASA is associated with better renal outcomes. ____________________________________________________________________________ Role - Literature review, chart review and depending on student enthusiasm- can write manuscript as well; IRB Status - approved; Skills - Literature review and chart review in Health link | 1 | tsingh@medicine.wisc.edu | Tripti | Singh | MD | Tripti Singh, tsingh@medicine.wisc.edu -- Co-Mentor: | Use of anticoagulation and outcomes in Lupus Nephritis with thrombotic microangiopathy | 4.128.770.852 | Nephrology | Use of anticoagulation and outcomes in Lupus Nephritis with thrombotic microangiopathy | The goal of the project is to look at outcomes of patients with lupus nephritis and thrombotic microangiopathy and see if any oral anticoagulation including ASA is associated with better renal outcomes. | Literature review, chart review and depending on student enthusiasm- can write manuscript as well | Literature review and chart review in Health link | approved | No | maybe | Yes | Not currently available to mentor other students | Anticoagulation in patients with concomitant lupus nephritis and thrombotic microangiopathy: a multicentre cohort study Ann Rheum Dis July 2019 Vol 78 No 7 | No | NA | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueVkR0DfiDiTD3w7MLDO7MBMpxYY2YAgzSZW83sk0t4vrokO-ZIO8-s4f5sQAP57m8 | |||||||
| 23/01/2020 | Medical Physics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Quantitative Analysis of X-Ray Phase Contrast Images of Mastectomy Specimens: Using newly constructed prototype x-ray multi-contrast (attenuation, phase, dark field) mammography system, images of 50 freshly resected mastectomy specimens have been acquired at the WIMR X-Ray Imaging Lab (https://www.medphysics.wisc.edu/research/ct/li/). The student will assist the mentor and the co-mentor to perform image quality assessment for each x-ray contrast mechanism as well as fused images of all three contrast mechanisms. The student will also participate in the statistical analysis of the assessment results. ____________________________________________________________________________ Role - The student will assist the mentor and the co-mentor to perform image quality assessment for each x-ray contrast mechanism as well as fused images of all three contrast mechanisms. The student will also participate in the statistical analysis of the assessment results.; IRB Status - UW Health Science IRB # 2016-0814; Skills - Basic knowledge in statistics and metrology | 1 | kli23@wisc.edu | Ke | Li | PhD | Ke Li, kli23@wisc.edu -- Co-Mentor: Amy Fowler afowler@uwhealth.rog | Assistant Professor | 6.082.624.566 | Amy Fowler | afowler@uwhealth.rog | Radiology | Quantitative Analysis of X-Ray Phase Contrast Images of Mastectomy Specimens | Using newly constructed prototype x-ray multi-contrast (attenuation, phase, dark field) mammography system, images of 50 freshly resected mastectomy specimens have been acquired at the WIMR X-Ray Imaging Lab (https://www.medphysics.wisc.edu/research/ct/li/). The student will assist the mentor and the co-mentor to perform image quality assessment for each x-ray contrast mechanism as well as fused images of all three contrast mechanisms. The student will also participate in the statistical analysis of the assessment results. | The student will assist the mentor and the co-mentor to perform image quality assessment for each x-ray contrast mechanism as well as fused images of all three contrast mechanisms. The student will also participate in the statistical analysis of the assessment results. | Basic knowledge in statistics and metrology | UW Health Science IRB # 2016-0814 | No | No (plan to use Dean's Office Funds) | Yes | PhD students | Li K, Zhang R, Garrett J, Ge Y, Ji X, Chen GH. “Design, Construction, and Initial Results of a Prototype Multi-Contrast X-Ray Breast Imaging System.” Proc SPIE. 2018;10573:105730W Zhang R, Li K, Garrett J, Chen GH. “Human-Compatible Multi-Contrast Mammographic Prototype System.” Proc SPIE. 2019; 10948 Zhang,R, Fowler,A, Wilke,L, Kelcz,F, Garrett,J, Chen,G, Li,K, Fast Data Acquisition for a Human-Compatible Multi-Contrast Breast Imaging System. Radiological Society of North America 2019 Scientific Assembly and Annual Meeting, December 1 - December 6, 2019, Chicago IL. archive.rsna.org/2019/19019681.html | Yes | Dr. Ran Zhang (rzhang229@wisc.edu) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuewgRHY3BICh481n4yWUhBRs1rVO_TY-4iJ41w6qWfqrZilZ7kF8dVfELLLXBdkE7U | |||||
| 24/01/2020 | Cell and Regenerative Biology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Analysis of Human Heart Tissue Samples for Precision Medicine: Precision medicine, wherein patients are treated based on their individual disease characteristics, is increasingly recognized as the future of modern health care, and holds great promise for the treatment of diseases characterized by genetic and phenotypic heterogeneity. Empowered by high throughput omics technologies, systems biology provides a global understanding of complex molecular interactions and is the enabling force for personalized medicine. Genomic information alone is not sufficient to understand complex disease phenotypes. In contrast, proteomics enables researchers to obtain real-time information on a person’s physiological status and to decipher how interactions at the molecular level. Cardiovascular disease (CVD) is the #1 cause of death globally, a major public health problem and economic burden to the people of Wisconsin. The complex and heterogeneous nature of CVD raises an urgent need for personalized medicine. In this project, we will perform high-resolution top-down proteomics analysis of a large cohort of patients with ischemic cardiomyopathy to provide a better understanding of the underlying disease mechanism and for better treatments on an individual basis. ____________________________________________________________________________ Role - The student is expected to 1) analyze the genotyping data and clinical information; 2) work closely with other members in the group to integrate the clinical data, genotyping data with proteomics data, which will be used to stratify patients into sub-groups to aid dissection of the molecular mechanisms underlying cardiac disease. ; IRB Status - Approved; Skills - Basic biochemistry and data analysis skills | 1 | ying.ge@wisc.edu | Ying | Ge | PhD | Ying Ge, ying.ge@wisc.edu -- Co-Mentor: | Professor | 6.082.654.744 | Analysis of Human Heart Tissue Samples for Precision Medicine | Precision medicine, wherein patients are treated based on their individual disease characteristics, is increasingly recognized as the future of modern health care, and holds great promise for the treatment of diseases characterized by genetic and phenotypic heterogeneity. Empowered by high throughput omics technologies, systems biology provides a global understanding of complex molecular interactions and is the enabling force for personalized medicine. Genomic information alone is not sufficient to understand complex disease phenotypes. In contrast, proteomics enables researchers to obtain real-time information on a person’s physiological status and to decipher how interactions at the molecular level. Cardiovascular disease (CVD) is the #1 cause of death globally, a major public health problem and economic burden to the people of Wisconsin. The complex and heterogeneous nature of CVD raises an urgent need for personalized medicine. In this project, we will perform high-resolution top-down proteomics analysis of a large cohort of patients with ischemic cardiomyopathy to provide a better understanding of the underlying disease mechanism and for better treatments on an individual basis. | The student is expected to 1) analyze the genotyping data and clinical information; 2) work closely with other members in the group to integrate the clinical data, genotyping data with proteomics data, which will be used to stratify patients into sub-groups to aid dissection of the molecular mechanisms underlying cardiac disease. | Intermediate | Basic biochemistry and data analysis skills | Approved | Yes | Yes | Yes | Genetic Counseling students, MPH students, PhD students, UW undergraduates interested in research | http://ge.crb.wisc.edu/publications.html | Yes | ANNA OLSON |
https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuclG-q3t4-ARelUmZWrBporcjlfeh9G-g3SGA1kb3o5VLIcyy4OrAVMoWYP9eUdlKY | |||||||
| 27/01/2020 | Neurological Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment: Our lab currently has multiple research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic brain edema and traumatic brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. ____________________________________________________________________________ Role - Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. ; IRB Status - N/A; Skills - Basic cellular and molecular techniques | 1 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Dr. Umadevi Wesley, PhD, Research Professor and Dis. Scientist wesley@neurosurgery.wisc.edu | Professor and Chair | 608 | Dr. Umadevi Wesley, PhD, Research Professor and Dis. Scientist | wesley@neurosurgery.wisc.edu | Neurological Surgery | • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment | Our lab currently has multiple research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic brain edema and traumatic brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. | Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. | Moderate to High | Basic cellular and molecular techniques | N/A | Yes | Yes | Yes | Not currently available to mentor other students | https://www.ncbi.nlm.nih.gov/pmc/?term=Dempsey+RJ%2C | Yes | Cassie Whiting | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucnBWXpL_t1dq1ib8JH8dbLQc6zh1SzaEJzz4JXerLfPjfReclIqKSzwyqc28uDfk0 | ||||
| 28/01/2020 | Neurological Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Reducing Inflammation after Spinal Cord Injury via Mineral Coated Microparticles Releasing Anti-Inflammatory Cytokines: Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. After SCI, inflammatory cytokines are strongly upregulated during the first 24 hours and there is a second wave of inflammatory cytokine expression around 14 days. Although, using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of an anti-inflammatory cytokine directly on the injury site, which coincides with critical stages of the ensuing inflammatory response, giving a sustained release for at least 14 days. For this project we will be contusing the rat spinal cord at the T10 level and treating it with microparticles delivering anti-inflammatory cytokines to reduce inflammation. The student will be responsible for helping with animal surgeries, measuring compound action potentials, and measuring cytokine levels in the spinal cord using enzyme-linked immunosorbent assay (ELISA) kits. If you are interested in learning more about the project, please contact Dan Hellenbrand Hellenbrand@neurosurgery.wisc.edu https://www.neurosurgery.wisc.edu/research/hanna/ ____________________________________________________________________________ Role - Student would be involved with rat surgeries, performing ELISAs, immunohistochemistry, and other bench top work.; IRB Status - n/a; Skills - The skills will be taught in lab. | 2 | hanna@neurosurgery.wisc.edu | Amgad | Hanna | MD | Amgad Hanna, hanna@neurosurgery.wisc.edu -- Co-Mentor: Daniel Hellenbrand hellenbrand@neurosurgery.wisc.edu | Associate Professor of Neurological Surgery | 0 | Daniel Hellenbrand | hellenbrand@neurosurgery.wisc.edu | Neurological Surgery | Reducing Inflammation after Spinal Cord Injury via Mineral Coated Microparticles Releasing Anti-Inflammatory Cytokines | Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. After SCI, inflammatory cytokines are strongly upregulated during the first 24 hours and there is a second wave of inflammatory cytokine expression around 14 days. Although, using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of an anti-inflammatory cytokine directly on the injury site, which coincides with critical stages of the ensuing inflammatory response, giving a sustained release for at least 14 days. For this project we will be contusing the rat spinal cord at the T10 level and treating it with microparticles delivering anti-inflammatory cytokines to reduce inflammation. The student will be responsible for helping with animal surgeries, measuring compound action potentials, and measuring cytokine levels in the spinal cord using enzyme-linked immunosorbent assay (ELISA) kits. If you are interested in learning more about the project, please contact Dan Hellenbrand Hellenbrand@neurosurgery.wisc.edu https://www.neurosurgery.wisc.edu/research/hanna/ | Student would be involved with rat surgeries, performing ELISAs, immunohistochemistry, and other bench top work. | The skills will be taught in lab. | n/a | No | Yes | Yes | PhD students | Hellenbrand DJ, Reichl KA, Travis BJ, Filipp ME, Khalil AS, Pulito DJ, Gavigan AV, Maginot ER, Arnold MT, Adler AG, Murphy WL, and Hanna AS. Sustained Interleukin-10 Delivery Reduces Inflammation and Improves Motor Function after Spinal Cord Injury. Journal of Neuroinflammation 2019, 16:93 Thompson CD, Zurko JC, Hanna BF, Hellenbrand DJ, and Hanna A. The Therapeutic Role of Interleukin-10 after Spinal Cord Injury. Journal of Neurotrauma. 2013, 30(15):1311-24. Hanna A, Thompson DL, Hellenbrand DJ, Lee JS, Madura CJ, Wesley MG, Dillon NJ, Sharma T, Enright CJ, Murphy WL Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury. Journal of Neuroscience Research 2016, 94:645-652. Filipp ME, Travis BJ, Henry SS, Idzikowski EC, Magnuson SA, Loh MYF, Hellenbrand DJ, and Hanna AS. Differences in neuroplasticity after spinal cord injury in varying animal models and humans. Neural Regeneration Research 2019, 14(1):7-19. | No | n/a | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud4G2SriIc5puqVx1rRZi3sMQ9-KDPvVPbEVWe-4YBsTmM4L8odyVzm5nZ1rEcDNfQ | |||||
| 29/01/2020 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Pediatric and Adolescent Transgender Health (PATH) Clinic Patient Database : See a description of the primary project below. In addition, the student would be invited to shadow in PATH clinic. There may be other opportunities to participate in recruitment of past PATH patients to the database as well. PROJECT TITLE: Pediatric and Adolescent Trans Health Clinic Database BACKGROUND: In 2012, the UW AFCH Pediatric and Adolescent Transgender Health (PATH) multidisciplinary clinic was founded and in 2015, the Transgender Youth Resource Network (TYRN) was created in partnership with the AFCH Child Health Advocacy Program. Together, we aim to address barriers and challenges faced by transgender and gender non-conforming youth by training medical and mental health providers and educators, supporting transgender youth and families, and working for more accessible care through policy and advocacy. However, we do not presently have a clear means to track how these changes effect long-term experience of trans and gender non-conforming (TGNC) youth treated in the UW Health system. RESEARCH DESIGN/METHODS: A database has been built in REDCAP to capture clinical data from transgender youth and families that consent to participate. The student role would involve assistance with data entry as families are consented. The student would also design their own research question to ask about the health and wellness of transgender, nonbinary, and gender diverse youth. AIMS/HYPOTHESIS: Aim #1 is to create a PATH clinic database to include clinical and demographic information that will promote future QI and research questions. Aim #2 is to procure long-term additional funding for this database in order to capture longitudinal data on this high-risked, under-studied pediatric population. We hope to ask a number of specific questions. One hypothesis is that the implementation of inclusive and affirming health care policies and clinical practices in the multidisciplinary PATH clinic will increase trust and mutual respect between adolescent TGNC patients, parents, and health care providers and result in a reduction of adolescent TGNC patients and their parents reports of experiencing incidents of violence, service refusal, and discrimination. PROJECTED RESULTS: The projected result would be a robust, unified, longitudinal database that incorporates vital clinical data from a high risk population. This database will provide much needed insight into long-term management of TGNC youth who are under-going hormonal manipulation including pubertal suppression and cross-gender hormone treatment. The creation of PATH clinic database will result in robust data for future QI and research projects that includes the complex risk factors seen in the population. ____________________________________________________________________________ Role - Data Entry for clinical database of transgender/nonbinary youth, design own research question based on clinical information available.; IRB Status - Under review; Skills - Basic data entry skills (most to be learned during training with research coordinator) | 2 | bjallen@pediatrics.wisc.edu | Brittany | Allen | MD | Brittany Allen, bjallen@pediatrics.wisc.edu -- Co-Mentor: Jennifer Rehm, MD jrehm@pediatrics.wisc.edu | Assistant Professor | 6.082.654.358 | GPAM | Jennifer Rehm, MD | jrehm@pediatrics.wisc.edu | Pediatrics | Pediatric Endocrine | Pediatric and Adolescent Transgender Health (PATH) Clinic Patient Database | See a description of the primary project below. In addition, the student would be invited to shadow in PATH clinic. There may be other opportunities to participate in recruitment of past PATH patients to the database as well. PROJECT TITLE: Pediatric and Adolescent Trans Health Clinic Database BACKGROUND: In 2012, the UW AFCH Pediatric and Adolescent Transgender Health (PATH) multidisciplinary clinic was founded and in 2015, the Transgender Youth Resource Network (TYRN) was created in partnership with the AFCH Child Health Advocacy Program. Together, we aim to address barriers and challenges faced by transgender and gender non-conforming youth by training medical and mental health providers and educators, supporting transgender youth and families, and working for more accessible care through policy and advocacy. However, we do not presently have a clear means to track how these changes effect long-term experience of trans and gender non-conforming (TGNC) youth treated in the UW Health system. RESEARCH DESIGN/METHODS: A database has been built in REDCAP to capture clinical data from transgender youth and families that consent to participate. The student role would involve assistance with data entry as families are consented. The student would also design their own research question to ask about the health and wellness of transgender, nonbinary, and gender diverse youth. AIMS/HYPOTHESIS: Aim #1 is to create a PATH clinic database to include clinical and demographic information that will promote future QI and research questions. Aim #2 is to procure long-term additional funding for this database in order to capture longitudinal data on this high-risked, under-studied pediatric population. We hope to ask a number of specific questions. One hypothesis is that the implementation of inclusive and affirming health care policies and clinical practices in the multidisciplinary PATH clinic will increase trust and mutual respect between adolescent TGNC patients, parents, and health care providers and result in a reduction of adolescent TGNC patients and their parents reports of experiencing incidents of violence, service refusal, and discrimination. PROJECTED RESULTS: The projected result would be a robust, unified, longitudinal database that incorporates vital clinical data from a high risk population. This database will provide much needed insight into long-term management of TGNC youth who are under-going hormonal manipulation including pubertal suppression and cross-gender hormone treatment. The creation of PATH clinic database will result in robust data for future QI and research projects that includes the complex risk factors seen in the population. | Data Entry for clinical database of transgender/nonbinary youth, design own research question based on clinical information available. | Near full independence. We have research coordinators that would help you learn the database entry. Drs. Rehm or Allen would meet with you once every 1-2 weeks to get updates, discuss your project design. | Basic data entry skills (most to be learned during training with research coordinator) | Under review | No | Yes | We would discuss the best option for computer (may be able to use personal device or check out Department of Peds Laptop) | Not currently available to mentor other students | Refereed Articles Under Review / In Press 1 Bizub B, Allen BJ. Creating an affirming environment for transgender, nonbinary, and gender diverse patients. Wisconsin Medical Journal. 2 Allen BJ, Andert B, Botsford J, Budge SL, Rehm JR. At the Margins: Comparing School Experiences of Nonbinary and Binary-identified Transgender Youth. Journal of School Health. 2019. Refereed Articles 1 Allen BJ, Allen DB. “Pediatric program directors’ perceptions of the ACGME duty hour standards.” Published online for the ACGME’s GME Focus in January 2014. Invited Articles 1 Allen BJ, Coles MS, Montano GT. A Call to Improve Guidelines for Transgender Health and Well-being: Promoting Youth-Centered and Gender-Inclusive Care. J Adolesc Health. 2019 Oct;65(4):443-445. doi: 10.1016/j.jadohealth.2019.07.020. PubMed PMID: 31542110. 2 Allen BJ. Challenges and Successes in Evaluating HIV Prevention for Young Transgender Women-Building Skills, Maintaining Trust. JAMA Pediatr. 2018 Oct 1;172(10):908-910. doi: 10.1001/jamapediatrics.2018.2334. PubMed PMID: 30105387. Non-Refereed Articles Chapters in Books 1 Allen BJ, Hohs S. Working with Trauma-Exposed Children and Adolescents: Evidence-Based and Age-Appropriate Practices. 1st ed. Pozzulo J, Bennell C, editors. New York: Routledge Taylor & Francis Group; 2019. Chapter 5, Promoting Safety for LGBTQ+ Kids in School Communities. 2 Allen BJ. Transgender Medicine: A Multidisciplinary approach. Poretsky L, Hembree WC, editors. Cham, Switzerland: Humana Press; 2019. Chapter 5, Primary Care of the Transgender Child and Adolescents Chapters in Books (submitted) 1 Sherer I, Allen BJ, Waters J, Hunt L. Providing Culturally Competent Care to Diverse Populations: Sexual Orientation and Gender Expression. In Berkowitz’s Pediatrics: A Primary care approach, 6th ed. 2 Allen BJ and Rosenthal SM. Pediatric Endocrinology: Essentials for Practice, 3rd Edition. Allen DB, Geffner ME, editors. McGraw-Hill. Chapter: Care of Transgender, Nonbinary, and Gender Diverse Youth. | No | Christine Richards (Administrative - GPAM) - crichards9@wisc.edu Kim Stevenson (Associate Director of Business Services, Pediatrics) - kdstevenson@pediatrics.wisc.edu Jennifer Rehm, MD - jrehm@pediatrics.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufcOoJfUAc1IRDC8ayXoETYkkLpQchB1nzTGfC6QdPr60NcQyQ_gvJ2MZlSpbZJmqM | ||
| 31/01/2020 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Asymptomatic viral upper respiratory tract infectionction: We have done a large prospective observational study of healthy children between 4 and 7 years of age . Each child, was followed for one year, and underwent sampling of their nose and nasopharynx four times a year for surveillance (when they were well) and whenever they were ill with upper respiratory symptoms such as nasal discharge, nasal congestion or cough. The samples were assayed for the presence of respiratory viruses by PCR and the presence of common bacteria by PCR. Approximately 80% of samples obtained from children who were ill showed the presence of a virus. Of interest, about 30% of children without symptoms also showed the presence of a virus. A study question of interest is whether these asymptomatic children who are virus positive are more likely to develop respiratory symptoms in the next 7 days than children who are asymptomatic and virus negative. If virus positive children do develop symptoms more often than their virus negative counterparts, is it with the same virus or a different virus. The large data base that is available can also be used to answer other questions. ____________________________________________________________________________ Role - Literature review, data analysis, abstract and paper submission; IRB Status - Not necessary - samples are de-identified; Skills - curiosity and industry | 1 | erwald@wisc.edu | Ellen | Wald | MD | Ellen Wald, erwald@wisc.edu -- Co-Mentor: Gregory DeMuri demuri@pediatrics.wisc.edu | Professor of Pediatrics; Chair Department of Pediatrics | 608 | Pediatric Infectious Disease | Gregory DeMuri | demuri@pediatrics.wisc.edu | Pediatrics | Pediatric Infectious Disease | Asymptomatic viral upper respiratory tract infectionction | We have done a large prospective observational study of healthy children between 4 and 7 years of age . Each child, was followed for one year, and underwent sampling of their nose and nasopharynx four times a year for surveillance (when they were well) and whenever they were ill with upper respiratory symptoms such as nasal discharge, nasal congestion or cough. The samples were assayed for the presence of respiratory viruses by PCR and the presence of common bacteria by PCR. Approximately 80% of samples obtained from children who were ill showed the presence of a virus. Of interest, about 30% of children without symptoms also showed the presence of a virus. A study question of interest is whether these asymptomatic children who are virus positive are more likely to develop respiratory symptoms in the next 7 days than children who are asymptomatic and virus negative. If virus positive children do develop symptoms more often than their virus negative counterparts, is it with the same virus or a different virus. The large data base that is available can also be used to answer other questions. | Literature review, data analysis, abstract and paper submission | Close mentoring will be available | curiosity and industry | Not necessary - samples are de-identified | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | DeMuri GP dt al. Clinical features, virus identification and sinusitis as a complication of upper respiratory tract illness in children ages 4-7 years. J Pediatr 2016: 133 DeMuri GP et al. Dynamics of bacterial colonization with Streptoococcus pneumonaie, Haemophilus influenzae and Moraxella catarrhalis during symptomatic and asymptomatic viral upper respiratory tract infection. Clin Infect Dis 2018:1045 DeMuri et al. Clinical and virological characteristics of acute sinusitis in children . Clin Infect Dise 2019: 1764 | Yes | None | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudE7ve-5abb5MIkc-ZTtlIHff4z5zOJ81DZSRlXcmvW54C7xkU-oVmvPhbZLUxIaBY | ||
| 31/01/2020 | Emergency Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Reducing Diagnostic Error in Adults with Pneumonia: This project will investigate a new imaging technique to generate a prevalence estimate for dysphagia-related aspiration in older adults with pneumonia and assess salivary biomarker association with health outcomes such as recurrent pneumonia. The aims of this project combine clinical and translational research, utilizing an observational cohort of older adults presenting with community acquired pneumonia and biochemical analysis of patient samples. The overall goal is to develop a reliable diagnostic process to identify aspiration syndromes to improve pneumonia evaluation and treatment, ultimately improving health outcomes for a substantial portion of older adults. ____________________________________________________________________________ Role - Depending on the specific interests and timeframe of applicants, this project has several opportunities for involvement from performing clinical research to collaborating on the translational work to characterize the oral microbiome and salivary biomarkers. ; IRB Status - Pending; Skills - High level communication skills including comfort interacting with patients and ability to collaborate effectively with other researchers. Experience or willingness to learn clinical research procedures, biochemical experimentation techniques and data analysis methods. | 1 | mspulia@medicine.wisc.edu | Michael | Pulia | MD MS | Michael Pulia, mspulia@medicine.wisc.edu -- Co-Mentor: Nicole Rogus-Pulia npulia@wisc.edu | Assistant Professor, Director of EM Antibiotic Stewardship | 708 | Nicole Rogus-Pulia | npulia@wisc.edu | Medicine | Geriatrics | Reducing Diagnostic Error in Adults with Pneumonia | This project will investigate a new imaging technique to generate a prevalence estimate for dysphagia-related aspiration in older adults with pneumonia and assess salivary biomarker association with health outcomes such as recurrent pneumonia. The aims of this project combine clinical and translational research, utilizing an observational cohort of older adults presenting with community acquired pneumonia and biochemical analysis of patient samples. The overall goal is to develop a reliable diagnostic process to identify aspiration syndromes to improve pneumonia evaluation and treatment, ultimately improving health outcomes for a substantial portion of older adults. | Depending on the specific interests and timeframe of applicants, this project has several opportunities for involvement from performing clinical research to collaborating on the translational work to characterize the oral microbiome and salivary biomarkers. | High | High level communication skills including comfort interacting with patients and ability to collaborate effectively with other researchers. Experience or willingness to learn clinical research procedures, biochemical experimentation techniques and data analysis methods. | Pending | Career Development Award | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Pulia M, Keller S, Crnich C, Jump R, Yoshikawa, T. Antibiotic Stewardship for Older Adults in Ambulatory Care Settings: Addressing an Unmet Challenge. Journal of the American Geriatrics Society. 2019 (in-press) Mewes J, Pulia M, Mansour M, Broyles M, Nguyen B, Steuten L. The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalized patients with suspected sepsis or lower respiratory tract infections in the US: a health economic model analysis. PLOS One. 2019;14(4). Pulia, M, Schulz L, Fox B. Procalcitonin-Guided Antibiotic Use (Correspondence). New England Journal of Medicine. 2018;379(20):1971-2. Pulia M, Redwood B, May L. Antimicrobial Stewardship in the Emergency Department. Emergency Medicine Clinics of North America. 2018;36(4):853-872. Pulia M, Kern M, Schwei R, Shah M, Sampene E, Crnich C. Comparative Analysis of Antibiotic Prescribing for Nursing Home Residents Treated In-Facility versus Outpatient Settings. Antimicrobial Resistance & Infection Control. 2018;74(7):1-8. | Yes | Jessie Libber, jslibber@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueX5llX5Ta71e69350__OME2YytnXUroXVo5IxxZ1bx6CG5Ff04uOKHBEjdZ5LyoYs | |||
| 31/01/2020 | Surgery | Research Electives for credit | Enhancing Interdisciplinary Care Skills through Self-Directed Longitudinal Care Experiences in Surgical Clerkship: A qualitative and quantitative analysis of the effectiveness of following a patient perioperatively through the completion of the Longitudinal Patient Project within the Surgical and Procedural Care Block of Phase II and the MD curriculum at the University of Wisconsin School of Medicine and Public Health in an effort to enhance interdisciplinary care skills of future practitioners and improve quality of patient care. ____________________________________________________________________________ Role - Research Assistant ; IRB Status - In progress; Skills - Basic understanding of quantitative and qualitative analysis | 1 | larsonsa@surgery.wisc.edu | Ann | O'Rourke | MD, MPH | Ann O'Rourke, larsonsa@surgery.wisc.edu -- Co-Mentor: Dorothy Cook, MS, Education Coordinator cookd@surgery.wisc.edu | Associate Professor | 6.082.633.633 | Acute Care & Regional General Surgery | Dorothy Cook, MS, Education Coordinator | cookd@surgery.wisc.edu | Surgery | Enhancing Interdisciplinary Care Skills through Self-Directed Longitudinal Care Experiences in Surgical Clerkship | A qualitative and quantitative analysis of the effectiveness of following a patient perioperatively through the completion of the Longitudinal Patient Project within the Surgical and Procedural Care Block of Phase II and the MD curriculum at the University of Wisconsin School of Medicine and Public Health in an effort to enhance interdisciplinary care skills of future practitioners and improve quality of patient care. | Research Assistant | Basic understanding of quantitative and qualitative analysis | In progress | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | N/A | Yes | Dorothy Cook, cookd@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufcLgZ3Rw0x0-7Q3E5uMVW3CNAZOBGpvyi5wfitzN6jex9JdEXcYFKYW-I-y-wv86c | ||||
| 04/02/2020 | Urology | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Renal cell cancer clinical and translational research projects: My focus is clinical and translational research in kidney cancer. We currently have multiple projects that are available for interested and motivated students. I have had the privilege of working with 18 medical students in the Shapiro program during the last 10 years at UW. Each student was able to publish and present their findings. Please email if interested and I would be happy to discuss individual projects with you. ____________________________________________________________________________ Role - collect data, analyze and publish if interested; IRB Status - approved; Skills - motivation | 2 | abel@urology.wisc.edu | E | Abel | MD | E Abel, abel@urology.wisc.edu -- Co-Mentor: | Associate professor | Other | Renal cell cancer clinical and translational research projects | My focus is clinical and translational research in kidney cancer. We currently have multiple projects that are available for interested and motivated students. I have had the privilege of working with 18 medical students in the Shapiro program during the last 10 years at UW. Each student was able to publish and present their findings. Please email if interested and I would be happy to discuss individual projects with you. | collect data, analyze and publish if interested | variable with experience | motivation | approved | Yes | Yes | Yes | PhD students | Dreyfuss LD, Wells SA, Best SL, Hedican SP, Ziemlewicz TJ, Lubner MG, Hinshaw JL, Lee FT, Nakada SY, Abel EJ. Development of a risk-stratified approach for follow-up imaging after percutaneous thermal ablation of sporadic stage one renal cell carcinoma. Urol. 2019 Oct. PMID: 31465794 | Yes | DENISE A MUSSEHL mussehl@urology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufhgMg5yHHqZW7DkJTRIitZV-FTWGIYQITlCYyTImEvmvceeAq_zyBJd1sMuaQ2YTQ | |||||||
| 05/02/2020 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Feasibility of an app to support enteral tube care for children with medical complexity: This project will enroll up to 30 caregivers into a 1-month feasibility trial of an innovative mobile application to support parents who deliver enteral tube (g-tube, gj-tube) care to a child with medical complexity. The study will evaluate how families use the app and begin to understand how the app improves child and family health. ____________________________________________________________________________ Role - Assist in recruiting up to 30 families. Design data collection process and conduct data collection Conduct analyses with guidance from mentor. Present findings to core team and steering committee. Work as a member of a collaborative multi-disciplinary team.; IRB Status - Currently under review; Skills - Comfort with Microsoft Office. Experience with clinical research (quantitative or qualitative) is desired. Organizational skills and positive attitude are important. | 1 | rcoller@pediatrics.wisc.edu | Ryan | Coller | MD, MPH | Ryan Coller, rcoller@pediatrics.wisc.edu -- Co-Mentor: Mary Ehlenbach, MD mehlenbach@pediatrics.wisc.edu | Chief, Division of Pediatric Hospital Medicine | 6.082.639.408 | Hospital Medicine | Mary Ehlenbach, MD | mehlenbach@pediatrics.wisc.edu | Pediatrics | Hospital Medicine | Feasibility of an app to support enteral tube care for children with medical complexity | This project will enroll up to 30 caregivers into a 1-month feasibility trial of an innovative mobile application to support parents who deliver enteral tube (g-tube, gj-tube) care to a child with medical complexity. The study will evaluate how families use the app and begin to understand how the app improves child and family health. | Assist in recruiting up to 30 families. Design data collection process and conduct data collection Conduct analyses with guidance from mentor. Present findings to core team and steering committee. Work as a member of a collaborative multi-disciplinary team. | Supported independence. Student will have daily autonomy with a daily touchpoint with the mentors, and weekly scheduled meetings. Student will work with research staff to support the work according to the rapid timeline. | Comfort with Microsoft Office. Experience with clinical research (quantitative or qualitative) is desired. Organizational skills and positive attitude are important. | Currently under review | UW ICTR, MCHB/HRSA | I believe our department supports Shapiro students | Yes | MPH students, PhD students, UW undergraduates interested in research | https://www.ncbi.nlm.nih.gov/pubmed/?term=coller+rj | No | Gemma Warner | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc-ZWD8UMTWc_5qkPBoYtm-juVm9sqzxbXY2ibl8GI6TsHqLK8sTy0eCpBsaZBVfQ8 | ||
| 05/02/2020 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit | Postpartum Ultrasonographic Evaluation of the Inferior Vena Cava Collapsibility Index and Caval Aorta Index as Predictors for Persistent Postpartum Hypertension (Postpartum IVC-Ao Trial): The purpose of this research project is to see how blood volumes change after a woman has a baby, as measured by the diameter of the large blood vessels of the body (inferior vena cava, aorta) and the arm (brachial artery). We will be studying postpartum women with and without high blood pressure to see how the parameters change during the postpartum period. We also will see if measuring the large blood vessels of the body can predict which patients are at risk for persistent high blood pressure after they are discharged from the hospital by following them with our Postpartum Hypertension Telehealth Program. ____________________________________________________________________________ Role - Subject identification, clinical data abstraction; IRB Status - In review; Skills - UPH-Meriter Epic access, CITI training, familiar with REDCap or Excel | 1 | jlracine@wisc.edu | Jenna | Racine | MD | Jenna Racine, jlracine@wisc.edu -- Co-Mentor: Igor Iruretagoyena, MD iruretagoyen@wisc.edu | Fellow Physician | 906 | Maternal-Fetal Medicine | Igor Iruretagoyena, MD | iruretagoyen@wisc.edu | Obstetrics & Gynecology | Maternal-Fetal Medicine | Postpartum Ultrasonographic Evaluation of the Inferior Vena Cava Collapsibility Index and Caval Aorta Index as Predictors for Persistent Postpartum Hypertension (Postpartum IVC-Ao Trial) | The purpose of this research project is to see how blood volumes change after a woman has a baby, as measured by the diameter of the large blood vessels of the body (inferior vena cava, aorta) and the arm (brachial artery). We will be studying postpartum women with and without high blood pressure to see how the parameters change during the postpartum period. We also will see if measuring the large blood vessels of the body can predict which patients are at risk for persistent high blood pressure after they are discharged from the hospital by following them with our Postpartum Hypertension Telehealth Program. | Subject identification, clinical data abstraction | UPH-Meriter Epic access, CITI training, familiar with REDCap or Excel | In review | Grant funding approval pending | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | 1) Role of IVC collapsibility index to predict post spinal hypotension in pregnant women undergoing caesarean section. An observational trial. Singh, Yudhyavir; Anand, Rahul; Gupta, Stuti; Chowdhury, Sumit; Maitra, Souvik; Baidya, Dalim; Singh, Akhil Saudi Journal of Anaesthesia, 2019, Vol.13(4), p.312-317 2) Oba T, Koyano M, Hasegawa J, Takita H, Arakaki T, Nakamura M, Sekizawa A. The inferior vena cava diameter is a useful ultrasound finding for predicting postpartum blood loss. Journal of Maternal-Fetal & Neonatal Medicine, 2019;32(19):3251-3254 3) Takata M, Nakatsuka M, Kudo T. Differential Blood Flow in Uterine, Ophthalmic, and Brachial Arteries of Preeclamptic Women. Obstet Gynecol. 2002;100(5):931- 939. 4) Ilyas A, Ishtiaq W, Assad S, Ghazanfar H, Mansoor S, Haris M, Qadeer A, Akhtar A. Correlation of IVC diameter and collapsibility index with central venous pressure in the assessment of intravascular volume in critically ill patients. Cureus 9(2): e1025. 5) Salama, ER, Elkashlan M. Pre-operative ultrasonographic evaluation of inferior vena cava collapsibility index and caval aorta index as new predictors for hypotension after indiction of spinal anesthesia. Eur J Anaesthesiol 2019; 36:297-302. 6) Sridhar H, Mangalore P, Chandrasekaran VP, ManikamR. Caval aorta index and central venous pressure correlation in assessing fluid status! “ultrasound bridging the gap” ISRN Emergency Medicine, 2012:1-5 7) ULTRASOUND BASED CFD ASSESMENT OF BRACHIAL ARTERY WALL SHEAR STRESS IN PREECLAMPTIC PREGNANCY. Ryan J. Pewowaruk, Jenna Racine, J. Igor Irugetagoyena, Alejandro Roldán-Alzate. Abstract submitted to Summer Biomechanics, Bioengineering and Biotransport Conference - June 2020 | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuekU91IptfoMUlOVfqSToA8kDpJzhmVXbVN9e7dxCXB8vMyxmFzGeFlFv5SK41lJPs | |||
| 07/02/2020 | Radiology | Shorter term projects | Implementation of Musculoskeletal, Neuroscience, and Behavioral Health Curriculum in US Medical Schools: Students wil work with the Integrated Block Leader for the Mind and Motion Block in the Forward Curriculum. While over half of medical schools in the U.S. have transitioned or are planning to transition to integrated multi-organ system-based preclinical blocks, the specifications of these courses varies widely depending on which disciplines are included, which learning activities are used, and how much time is dedicated to each course. This is particularly true for the musculoskeletal, neuroscience, and behavioral science content. The goal of this project is to interrogate the curricula of the 179 medical schools in the U.S. and gather data on the specifications of how MSK/Neuro/Psych content is implemented at each. The tools of this research will be web investigation as well as email and telephone correspondence with curricular representatives from institutions across the country. Students will have independent responsibility for gathering and processing data and maintaining the course profile database. Analysis of data and review of curricular designs will also include discussions of curriculum design principles, cognitive theories, and best practices of learning activity development. Students will also have a unique behind the scenes look at the sub-structure of the Mind & Motion Block. ____________________________________________________________________________ Role - Primary information gathering, cateorization, and analysis using web research, email, and telephone correspondence; IRB Status - n/a; Skills - Web research, document organization, database entry, phone interviewing, email correspondence. | 1 | jstephenson@uwhealth.org | Jason | Stephenson | MD | Jason Stephenson, jstephenson@uwhealth.org -- Co-Mentor: | Associate Professor of Radiology; Mind & Motion Integrated Block Leader | 608 | Musculoskeletal Imaging and Intervention | Other | Medical Sciences (Curricular) | Implementation of Musculoskeletal, Neuroscience, and Behavioral Health Curriculum in US Medical Schools | Students wil work with the Integrated Block Leader for the Mind and Motion Block in the Forward Curriculum. While over half of medical schools in the U.S. have transitioned or are planning to transition to integrated multi-organ system-based preclinical blocks, the specifications of these courses varies widely depending on which disciplines are included, which learning activities are used, and how much time is dedicated to each course. This is particularly true for the musculoskeletal, neuroscience, and behavioral science content. The goal of this project is to interrogate the curricula of the 179 medical schools in the U.S. and gather data on the specifications of how MSK/Neuro/Psych content is implemented at each. The tools of this research will be web investigation as well as email and telephone correspondence with curricular representatives from institutions across the country. Students will have independent responsibility for gathering and processing data and maintaining the course profile database. Analysis of data and review of curricular designs will also include discussions of curriculum design principles, cognitive theories, and best practices of learning activity development. Students will also have a unique behind the scenes look at the sub-structure of the Mind & Motion Block. | Primary information gathering, cateorization, and analysis using web research, email, and telephone correspondence | high | Web research, document organization, database entry, phone interviewing, email correspondence. | n/a | No | Yes | Yes | DPT students, MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | none | Yes | Lorene Seman (LSeman@uwhealth.org) | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud1PdbvMspI5bH_kRmsco5bBUYtOkRIKGuzdeDt0fe25s-_JPG5OO6Pv9kJy7qzN1Y | ||||
| 12/02/2020 | Neurological Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Anatomical and Physiological Characterization of Cranial Nerve Anatomy for Refinement of Neuromodulatory Therapies: Electrical stimulation of the cranial nerves, in particular the Trigeminal and Vagus, represents a rapidly growing strategy for therapeutic intervention for many neurological disorders. However, there are surprisingly few studies that characterize the anatomy of these nerves as it pertains to the activation of the local nerve fibers that lead to therapeutic benefit. Recent work in large animal models demonstrates well conserved anatomical organization that may be advantageous to exploit in the design of electrodes and stimulation paradigms. However, the fasciular organization of these has not been well elaborated in the human. This project will seek to characterize the organization of the vagus and trigeminal using a variety of imaging methodologies, microdisection and histology with the long term goal of developing intraoperative mapping strategies to improve the response of patients to cranial nerve neuromodulation. ____________________________________________________________________________ Role - Students may participate in imaging of specimens as well as microdissections. Students will analyze imaging and histological data to characterize the anatomy of nerves across specimens. ; IRB Status - N/A; Skills - Basic computer literacy and the willingness to learn methodology to analyze histological and imaging data. Programming in matlab or python is a bonus. | 1 | suminski@neurosurgery.wisc.edu | Aaron | Suminski | Ph.D. | Aaron Suminski, suminski@neurosurgery.wisc.edu -- Co-Mentor: Dr. Wendell Lake lake@neurosurgery.wisc.edu | Senior Scientist | 6.082.636.963 | Other | Biomedical Engineering | Dr. Wendell Lake | lake@neurosurgery.wisc.edu | Neurological Surgery | Anatomical and Physiological Characterization of Cranial Nerve Anatomy for Refinement of Neuromodulatory Therapies | Electrical stimulation of the cranial nerves, in particular the Trigeminal and Vagus, represents a rapidly growing strategy for therapeutic intervention for many neurological disorders. However, there are surprisingly few studies that characterize the anatomy of these nerves as it pertains to the activation of the local nerve fibers that lead to therapeutic benefit. Recent work in large animal models demonstrates well conserved anatomical organization that may be advantageous to exploit in the design of electrodes and stimulation paradigms. However, the fasciular organization of these has not been well elaborated in the human. This project will seek to characterize the organization of the vagus and trigeminal using a variety of imaging methodologies, microdisection and histology with the long term goal of developing intraoperative mapping strategies to improve the response of patients to cranial nerve neuromodulation. | Students may participate in imaging of specimens as well as microdissections. Students will analyze imaging and histological data to characterize the anatomy of nerves across specimens. | Medium | Basic computer literacy and the willingness to learn methodology to analyze histological and imaging data. Programming in matlab or python is a bonus. | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201970090 https://www.sciencedirect.com/science/article/pii/S095656631930572X https://www.sciencedirect.com/science/article/pii/S0165027019301797 https://www.biorxiv.org/content/10.1101/856989v2.abstract | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudyZUm0MF9gCW_bysHJmbedp54C5ZupyZnA9_ugO3N-Qc0ENhhp-0vtT95StmtTUfA | ||
| 18/02/2020 | Pediatrics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Novel RNA therapeutics for pediatric blindness: Suppressor tRNA mediated gene therapy is a novel approach. tRNAs are the adaptor molecule involved in protein translation. A nonsense mutation pauses a protein translation resulting in a truncated protein product, providing an opportunity for the use of engineered tRNA to complete protein synthesis. Several ion-channel gene mutations in the retinal photoreceptors and pigment epithelium cells cause congenital vision loss. In our lab, we have studied Leber Congenital Amaurosis (LCA16) using patient derived iPSC-RPE cells and developed both drug and gene therapy to be used for clinical trial very soon. In the current project, the student will be involved in developing an alternate cure for genetic disease, beyond gene therapy, by measuring phenotypic suppression after effective engineered tRNA delivery. ____________________________________________________________________________ Role - Set up experiments and record experimental outcome. Prepare results and present in the lab. Write up the findings for future use in publications.; IRB Status - Not required; Skills - Critical thinking, and detailed oriented. | 1 | pattnaik@wisc.edu | Bikash | Pattnaik | PhD | Bikash Pattnaik, pattnaik@wisc.edu -- Co-Mentor: | Assistant Professor @ Clinical Director Visual Electrophysiology | 6.082.659.486 | Neonatology | Ophthalmology and Visual Sciences | Clinical Electrophysiology/Pediatrics Vision | Novel RNA therapeutics for pediatric blindness | Suppressor tRNA mediated gene therapy is a novel approach. tRNAs are the adaptor molecule involved in protein translation. A nonsense mutation pauses a protein translation resulting in a truncated protein product, providing an opportunity for the use of engineered tRNA to complete protein synthesis. Several ion-channel gene mutations in the retinal photoreceptors and pigment epithelium cells cause congenital vision loss. In our lab, we have studied Leber Congenital Amaurosis (LCA16) using patient derived iPSC-RPE cells and developed both drug and gene therapy to be used for clinical trial very soon. In the current project, the student will be involved in developing an alternate cure for genetic disease, beyond gene therapy, by measuring phenotypic suppression after effective engineered tRNA delivery. | Set up experiments and record experimental outcome. Prepare results and present in the lab. Write up the findings for future use in publications. | Some guidance will be provided. | Critical thinking, and detailed oriented. | Not required | Yes | Yes | Yes | Genetic Counseling students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Pattnaik BR, Marino MJ, Chiang J, Pillers DA, and Traboulsi EI. A novel nonsense mutation W53X in KCNJ13 gene causes Leber Congenital Amaurosis (2015). Human Mutation 36: 720-727 Shahi PK, Hermans D, Sinha D, Brar S, Moulton H, Stulo S, Borys KD, Capowski E, Pillers DM, Gam DM, Pattnaik BR. Gene augmentation and read-through rescue channelopathy in an iPSC-RPE model of congenital blindness (2018). Am J Hum Genet. 2019 Feb 7;104(2):310-318. doi: 10.1016/j.ajhg.2018.12.019. PMID: 30686507 Chen G, Abdeen, AA, Wang Y, Shahi PK, Robertson S, Xie R, Suzuki M, Pattnaik BR, Saha K, and Gong S. A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing (2019). Nature Nanotechnology doi:10.1038/s41565-019-0539-2 | Yes | Pawan Shahi | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudynMrPOQsUrORrfgN5AEoD9_li8D-M4eQqstGJUp4FyWa6ZXuYUgDMirAyQGiovOE | ||||
| 19/02/2020 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Radiographic Outcomes in Humerus Fractures in Low- and Middle-Income Countries: In resource-limited settings, patients with long bone fractures often experience significant delays in obtaining care following an injury. There are many barriers to securing care, including inability to pay, lack of transportation to regional hospitals, and paucity of trained personnel. Due to these factors, operative management is often delayed, and in certain circumstances, fractures are managed non-operatively or with rudimentary surgical techniques. The Surgical Implant Generation Network (SIGN) intramedullary nailing system was designed to be used in resource-limited settings at low cost and without the need for fluoroscopy, a fracture table, or power reaming. The SIGN nail was designed to minimize valuable operating room resources and overcome some of the barriers to surgical care. A growing body of literature has shown favorable outcomes after treatment of femoral and tibial fractures using this system. The SIGN nail can also be utilized to provide surgical fixation/stabilization of fractures of the humeral shaft (upper arm). However, published literature is lacking with regard to outcomes following humeral shaft fracture fixation. Building on the work performed by my Shapiro research student from last summer, the current project will be a retrospective analysis of humerus fractures treated with a SIGN nail, as identified through the SIGN online surgical database. The SIGN database is a prospectively populated clinical database with anonymized data of patients treated with the SIGN nails. Five hundred humeral fractures treated with a SIGN nail will be chosen at random for sampling. The primary outcome measure will be post-operative alignment in both the coronal and sagittal planes (as seen on the AP and lateral radiographs, respectively). Demographics, fracture patterns and other features of clinical care will also be recorded. Secondary outcomes investigated (and recorded in the SIGN Online Surgical Database) include: fracture union (healing), infection, secondary surgery, and range-of-motion. The main goal of this project is to assess operative reduction of humeral fractures using the SIGN intramedullary nail. Secondary aims include assessing correlations between postoperative alignment and other collected variables. ____________________________________________________________________________ Role - This retrospective review will require students to utilize the SIGN database, a de-identified, online surgical database which includes pre- and post-operative X-ray images. Students will measure coronal and sagittal postoperative alignment using an onscreen protractor tool. Students will also gather information on basic demographics, injury mechanism and surgical details including type of implant, open versus closed fracture, delay to surgical fixation and operative time in order to evaluate the secondary outcome measures. ; IRB Status - Approved; Skills - Basic data entry and chart review skills | 1 | whiting@ortho.wisc.edu | Paul | Whiting | MD | Paul Whiting, whiting@ortho.wisc.edu -- Co-Mentor: | Assistant Professor of Orthopedics & Rehabilitation | 608 | Orthopaedic Trauma | Radiographic Outcomes in Humerus Fractures in Low- and Middle-Income Countries | In resource-limited settings, patients with long bone fractures often experience significant delays in obtaining care following an injury. There are many barriers to securing care, including inability to pay, lack of transportation to regional hospitals, and paucity of trained personnel. Due to these factors, operative management is often delayed, and in certain circumstances, fractures are managed non-operatively or with rudimentary surgical techniques. The Surgical Implant Generation Network (SIGN) intramedullary nailing system was designed to be used in resource-limited settings at low cost and without the need for fluoroscopy, a fracture table, or power reaming. The SIGN nail was designed to minimize valuable operating room resources and overcome some of the barriers to surgical care. A growing body of literature has shown favorable outcomes after treatment of femoral and tibial fractures using this system. The SIGN nail can also be utilized to provide surgical fixation/stabilization of fractures of the humeral shaft (upper arm). However, published literature is lacking with regard to outcomes following humeral shaft fracture fixation. Building on the work performed by my Shapiro research student from last summer, the current project will be a retrospective analysis of humerus fractures treated with a SIGN nail, as identified through the SIGN online surgical database. The SIGN database is a prospectively populated clinical database with anonymized data of patients treated with the SIGN nails. Five hundred humeral fractures treated with a SIGN nail will be chosen at random for sampling. The primary outcome measure will be post-operative alignment in both the coronal and sagittal planes (as seen on the AP and lateral radiographs, respectively). Demographics, fracture patterns and other features of clinical care will also be recorded. Secondary outcomes investigated (and recorded in the SIGN Online Surgical Database) include: fracture union (healing), infection, secondary surgery, and range-of-motion. The main goal of this project is to assess operative reduction of humeral fractures using the SIGN intramedullary nail. Secondary aims include assessing correlations between postoperative alignment and other collected variables. | This retrospective review will require students to utilize the SIGN database, a de-identified, online surgical database which includes pre- and post-operative X-ray images. Students will measure coronal and sagittal postoperative alignment using an onscreen protractor tool. Students will also gather information on basic demographics, injury mechanism and surgical details including type of implant, open versus closed fracture, delay to surgical fixation and operative time in order to evaluate the secondary outcome measures. | After initial training, students will be expected to conduct electronic medical record review and radiographic review for study patients and maintain a database independently. The student will also be given the opportunity to assist the research mentor and co-mentors in literature review, manuscript preparation, and project presentation. Authorship will be granted for any presentation(s)/publication from this project. | Basic data entry and chart review skills | Approved | No | Yes | Yes | Not currently available to mentor other students | “Satisfactory Postoperative Alignment Following Retrograde SIGN Fin Nailing for Femoral Shaft Fractures: A Case-Control Study” (Published in Orthopaedic Trauma Association – International journal October 2019). "Clinical and Radiographic Outcomes Following SIGN Fin Nailing for Femoral Shaft Fractures"(Accepted for publication in Orthopaedic Trauma Association – International journal). | Yes | Kristina Johnson (Orthopaedic Trauma Research Coordinator): otrc@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudDwE4qN1kqMGALdtQlCepyQGgT9uyX6AgaixhiSOXJcy4UTI3GjWVPtJcRgnrvDCA | ||||||
| 19/02/2020 | Obstetrics & Gynecology | Shorter term projects | Substance Use Screening Practices Among Prenatal Care Provider Groups: This study aims to evaluate current screening practices among UW Health prenatal care provider groups, including Family Medicine, Academic Specialists in General Obstetrics and Gynecology, Maternal Fetal Medicine, UW Certified Nurse Midwives and OB and FM resident continuity clinic patients through a retrospective descriptive study. The study will involve working with health information specialists to abstract data from the electronic medical record as well as manual chart review. The information from this study will inform the goal of improving substance use screening during pregnancy and serve as baseline data for future comparison. ____________________________________________________________________________ Role - Student will receive specific instructions and develop clear goals and timeline with mentor. Student will learn about and assist with literature search, project design, data collection, and manuscript writing. I expect this project would result in a local poster presentation.; IRB Status - IRB exempt; Skills - Commitment and good communication. Other skills can be trained as needed. | 1 | rcmcdonald@wisc.edu | Ryan | McDonald | MD | Ryan McDonald, rcmcdonald@wisc.edu -- Co-Mentor: | Associate Professor | 608 | Academic Specialists in General Obstetrics and Gynecology | Substance Use Screening Practices Among Prenatal Care Provider Groups | This study aims to evaluate current screening practices among UW Health prenatal care provider groups, including Family Medicine, Academic Specialists in General Obstetrics and Gynecology, Maternal Fetal Medicine, UW Certified Nurse Midwives and OB and FM resident continuity clinic patients through a retrospective descriptive study. The study will involve working with health information specialists to abstract data from the electronic medical record as well as manual chart review. The information from this study will inform the goal of improving substance use screening during pregnancy and serve as baseline data for future comparison. | Student will receive specific instructions and develop clear goals and timeline with mentor. Student will learn about and assist with literature search, project design, data collection, and manuscript writing. I expect this project would result in a local poster presentation. | Varies by student's experience level | Commitment and good communication. Other skills can be trained as needed. | IRB exempt | Not for this project | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | None | No | Andrea Zorbas, Ob/Gyn research manager, zorbas@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuctyKP7lycGE7lcyHCznQcXNxTV8zAhwOKIyXBbKQE5c0yUhdFp0SObp6sAfiu0syU | ||||||
| 06/05/2020 | Academic Affairs | Shorter term projects | Improving University of Wisconsin-Madison ICEP Global Evaluation Survey: The project aims at improving an evaluation instrument that the University of Wisconsin-Madison Interprofessional Continuing Education Partnership (ICEP) is using to annually collect feedback, statements about changes resulting from participation in education, and suggestions for improvement from thousands of participants in educational activities accredited by ICEP. The ICEP Global Evaluation Survey is used since 2016 to help the planners evaluate and improve ICEP educational activities, including the growing number of interprofessional activities. The surveyors would like to make this survey more efficient by converting several open-ended questions to multiple-choice questions, based on the analysis of responses to open-ended questions that were collected during the past 4 years. Additional sources of data to support this conversion can be used, including existing evaluation summaries of individual activities. ____________________________________________________________________________ Role - Work under the guidance of Barbara Anderson to (a) conduct qualitative analysis of responses to open-ended questions, using qualitative software NVivo 12, (b) participate in discussions with Barbara Anderson, Marianna Shershneva, and ICEP staff about survey changes, and (c) prepare technical report to describe the methods, results, and recommended changes to the survey questions. Necessary methodology training will be provided. All work can be done remotely.; IRB Status - N/A; Skills - Knowledge of principles of qualitative research and academic writing skills. Skills to work with NVivo are preferred but not necessary. Note: qualitative software NVivo 12 is available to UW community for free. | 1 | barbara.anderson@wisc.edu | Barbara | Anderson | MS | Barbara Anderson, barbara.anderson@wisc.edu -- Co-Mentor: Marianna Shershneva, MD, PhD, CPD Evaluation and Assessment Specialist marianna.shershneva@wisc.edu | Director, Office of Continuing Professional Development | 608 | Office of Continuing Professional Development in Medicine and Public Health | Marianna Shershneva, MD, PhD, CPD Evaluation and Assessment Specialist | marianna.shershneva@wisc.edu | Academic Affairs | Office of Continuing Professional Development in Medicine and Public Health | Improving University of Wisconsin-Madison ICEP Global Evaluation Survey | The project aims at improving an evaluation instrument that the University of Wisconsin-Madison Interprofessional Continuing Education Partnership (ICEP) is using to annually collect feedback, statements about changes resulting from participation in education, and suggestions for improvement from thousands of participants in educational activities accredited by ICEP. The ICEP Global Evaluation Survey is used since 2016 to help the planners evaluate and improve ICEP educational activities, including the growing number of interprofessional activities. The surveyors would like to make this survey more efficient by converting several open-ended questions to multiple-choice questions, based on the analysis of responses to open-ended questions that were collected during the past 4 years. Additional sources of data to support this conversion can be used, including existing evaluation summaries of individual activities. | Work under the guidance of Barbara Anderson to (a) conduct qualitative analysis of responses to open-ended questions, using qualitative software NVivo 12, (b) participate in discussions with Barbara Anderson, Marianna Shershneva, and ICEP staff about survey changes, and (c) prepare technical report to describe the methods, results, and recommended changes to the survey questions. Necessary methodology training will be provided. All work can be done remotely. | Independent work under supervision | Knowledge of principles of qualitative research and academic writing skills. Skills to work with NVivo are preferred but not necessary. Note: qualitative software NVivo 12 is available to UW community for free. | N/A | No | Yes | Yes | DPT students, Genetic Counseling students, MPH students | Multiple presentations at professional conferences, including Alliance for Continuing Education in the Health Professions conference, Society for Academic Continuing Medical Education annual meeting, and National Center for Interprofessional Practice and Education (NEXUS) conference. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudTjKEce4gAbmLuh51QuKnkN8Ta1xbILWkprCTw_F-rGEv1DCorK3msR3_9W0XLlsA | ||
| 06/05/2020 | Academic Affairs | Shorter term projects | Exploring Diversity and Inclusion in the UW-Madison ICEP Program: The project aims at assessment of diversity and inclusion in the University of Wisconsin-Madison Interprofessional Continuing Education Partnership (ICEP) program. The ICEP program includes hundreds of continuing education activities for healthcare professionals each year. The scope of the project will be limited to a segment of the program, possibly, to activities addressing mental health topics. Methods include review of activity titles, topics, learning objectives, presenters, clinical cases and examples used in the content, and evaluation summaries to identify features consistent with the University of Wisconsin inclusion and diversity policies and guidelines. ____________________________________________________________________________ Role - Work under the guidance of Barbara Anderson to (a) refine the project scope, (b) establish metrics for review, (c) review provided educational materials, and (d) prepare technical report to describe the methods, results, and recommendations for the ICEP Program. Necessary methodology training will be provided. All work can be done remotely. ; IRB Status - N/A; Skills - Knowledge of and interest in the topic of diversity and inclusion, and academic writing skills. | 1 | barbara.anderson@wisc.edu | Barbara | Anderson | MS | Barbara Anderson, barbara.anderson@wisc.edu -- Co-Mentor: Marianna Shershneva, MD, PhD, CPD Evaluation and Assessment Specialist marianna.shershneva@wisc.edu | Director, Office of Continuing Professional Development | 608 | Office of Continuing Professional Development in Medicine and Public Health | Marianna Shershneva, MD, PhD, CPD Evaluation and Assessment Specialist | marianna.shershneva@wisc.edu | Academic Affairs | Office of Continuing Professional Development in Medicine and Public Health | Exploring Diversity and Inclusion in the UW-Madison ICEP Program | The project aims at assessment of diversity and inclusion in the University of Wisconsin-Madison Interprofessional Continuing Education Partnership (ICEP) program. The ICEP program includes hundreds of continuing education activities for healthcare professionals each year. The scope of the project will be limited to a segment of the program, possibly, to activities addressing mental health topics. Methods include review of activity titles, topics, learning objectives, presenters, clinical cases and examples used in the content, and evaluation summaries to identify features consistent with the University of Wisconsin inclusion and diversity policies and guidelines. | Work under the guidance of Barbara Anderson to (a) refine the project scope, (b) establish metrics for review, (c) review provided educational materials, and (d) prepare technical report to describe the methods, results, and recommendations for the ICEP Program. Necessary methodology training will be provided. All work can be done remotely. | Independent work under supervision | Knowledge of and interest in the topic of diversity and inclusion, and academic writing skills. | N/A | No | Yes | Yes | DPT students, Genetic Counseling students, MPH students | Multiple presentations at professional conferences, including Alliance for Continuing Education in the Health Professions conference, Society for Academic Continuing Medical Education annual meeting, and National Center for Interprofessional Practice and Education (NEXUS) conference. | No | N/A | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucVgAyOwINrZ4alv8CA6iXgx3mIOEpZb1rIGWHwc6HcZyhAtS5Io6imF8JZbyUwHWs | ||
| Timestamp | Department | Opportunities | Project Info | Open Slots | Email Address | Mentor First Name | Mentor Last Name | Degree | Mentor Information | Title | Phone Number | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Please list all relevant manuscripts (published or in preparation) in the last 5 years that are directly relevant to the project you proposed. | Have you completed any mentoring training? | Please include names and contact information of key staff in your department or lab who will need to be informed of your incoming Shapiro students | Response URL |