Please note that ALL projects with open slots are available to Shapiro applicants. “Non-Shapiro Opportunities” refer to opportunities available for medical students interested in a shorter term (non-summer) projects and yearlong projects.
Summer Research 2024
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Non-Shapiro Opportunities | Project Information | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | blank 1 | Mentor Information | Response |
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| 11/04/2022 | epetty@wisc.edu | Elizabeth | Petty | MD | Professor, Senior Associate Dean | 608 | Pediatrics | Shorter term projects | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning: The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - N/A; Skills - Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | Pediatrics - Genetics and Metabolism | Other | Academic Affairs - Dean's Office Administration | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning | The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. | 0 | Depends on student’s interests | Students will meet with mentors formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily avaiable. | Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | N/A | Yes | Yes | Yes | Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Unsure / Depends | Unsure / Depends | N/A | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufZw3OS9lCS7uri7zJAoaBdCeyU06-llc-3Rw64OPmTORz5oAJGP_ALFJ4YOx8Lo1A | |||||
| 11/09/2023 | epetty@wisc.edu | Elizabeth | Petty | MD | Professor, Senior Associate Dean | Academic Affairs | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Improving Education and Student Services for Medical and/or Other Health Professions Students at UWSMPH : In academic affairs we are committed to continuous quality improvement that enhance learning, optimize the learning environment, improve student outcomes, and/or promote student wellbeing. There are multiple projects that students could lead that would accelerate progress in areas related to any of the above depending on student interests, goals, and experience. I would welcome an opportunity to discuss possible projects with you. ____________________________________________________________________________ Role - Will depend on the specific project but may involve annotated literature review, analyses of existing data sets or resources, collection and analyses of new data from focus groups or surveys, and writing up results for publication and/or presentation. ; IRB Status - Most projects in this category with be focused on quality improvement and may not require an IRB. Some may require modifications of an existing IRB if part of a larger ongoing project. If a new IRB is needed, it will be submitted by March 2024. ; Skills - Curiosity, creativity, strong communication skills, and a collaborative spirit are a must. Previous research experience may be helpful depending on the project, but we will work together to design projects that compliment or augment existing skills. We will identify co-mentors as needed to ensure timely completion and additional expertise for the project. | Pediatrics | TBD depending on project | Improving Education and Student Services for Medical and/or Other Health Professions Students at UWSMPH | In academic affairs we are committed to continuous quality improvement that enhance learning, optimize the learning environment, improve student outcomes, and/or promote student wellbeing. There are multiple projects that students could lead that would accelerate progress in areas related to any of the above depending on student interests, goals, and experience. I would welcome an opportunity to discuss possible projects with you. | 0 | Will depend on the specific project but may involve annotated literature review, analyses of existing data sets or resources, collection and analyses of new data from focus groups or surveys, and writing up results for publication and/or presentation. | Students would work independently or in small collaborative groups depending on the specific project and would meet with me and any co-mentors and collaborative teams at least weekly. | Curiosity, creativity, strong communication skills, and a collaborative spirit are a must. Previous research experience may be helpful depending on the project, but we will work together to design projects that compliment or augment existing skills. We will identify co-mentors as needed to ensure timely completion and additional expertise for the project. | Most projects in this category with be focused on quality improvement and may not require an IRB. Some may require modifications of an existing IRB if part of a larger ongoing project. If a new IRB is needed, it will be submitted by March 2024. | Depends on the project. Discretionary funds appropriate for successful completion of the project will be made available. | Yes | Yes | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Yes | Yes | Susan Jeannette | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: TBD depending on project | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufcIKD0RRaIRMV45Wab6sKN67klIA3G39N3yGyG5Qq9ic41Mcgy688i1-eSUftCpQk | |||||||
| 11/10/2023 | epetty@wisc.edu | Elizabeth | Petty | MD | Professor, Senior Associate Dean | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Advancing LGBTQIA+ Education, Equity and Support in Academic Medicine: The broad goal of this work is to improve health outcomes and optimizing wellbeing for members of the LGBTQIA+ community through enhancing education and support initiatives in academic medicine. To date, medical and genetic counseling students at SMPH have worked on various projects, from doing a national review of the literature on LGBTQIA+ curriculum in medical schools and examining the content and effectiveness of the SMPH Phase 1 curriculum to understanding how genetic counselors use gender affirming language in health care settings and analyzing how genetic counseling programs across the country prepare learners to care for LGBTQIA+ patents. There are opportunities to do more, building on existing projects or creating a new project with a specific focus to improve knowledge, skills, and services for individuals who identify as LGBTQIA+. Collaborative projects and interprofessional projects are possible depending on student interests. All projects would be developed in close collaboration with the mentor/research team with clear hypotheses, goals, and aims. Some of the potential ideas for projects include, but are not limited to: 1) Unpacking UWSMPH learner experiences with LGBTQIA+ health education through focus groups or surveys: This study could be part of a larger project looking at LGBTQIA+ health education for medical students or could look more broadly at students across different health professions. The primary goal is to gain a better understanding of student experiences learning about LGBTQ+ health within and outside of school, as well as their self-perceived knowledge and readiness to care for LGBTQ+ patients. 2) Exploring medical or other health professional learner experiences at UWSMPH based on gender and/or sexual orientation: This project aims to illuminate experiences of learners throughout their learning at UWSMPH, and in particular will explore how gender, and potentially sexual orientation as well, may impact student experiences. This project can utilize some pre-existing data as well as obtain additional data through focus groups (or another method based on discussion with the student and mentor). 3) Exploring opportunities to learn about LGBTQ+ health in clinical rotations (e.g., phases 2 and 3 for medical students) at UWSMPH. This study could be part of a larger ongoing project looking at LGBTQ+ health education for medical students. The primary goal of this component is to gain a better understanding of opportunities to learn about LGBTQ+ health on clinical rotations (both required and elective, both in Madison and at statewide sites). Similar work could also be done for other health professions clinical rotations (e.g. prenatal clinic for genetic counselors), as part of a residency program or fellowship project, or part of a MPH scholarly project. 3) Doing a comprehensive annotated literature review regarding how medical, public health, and/or health professions schools measure and address bias against LGBTQ+ people among learners: This project involves a methodical and comprehensive literature review on this topic. There is also the possibility to expand this project to consider this topic specifically within UWSMPH educational programs. 4) Understanding experiences of LGBTQIA+ faculty and/or staff in academic medicine regarding their experiences and the impact their gender and/or sexuality impacted their career path, opportunities for promotion, and wellbeing. This could be a narrative story telling project that captures unique perspectives of faculty throughout their careers as a member of the LGBTQIA+ community. 5) Examining pharmaceutical, medical device, reproductive services, and/or clinical service advertisements for LGBTQIA+ representation and inclusion. This would involved a focused rigorous approach to examine how medical services are currently and/or historically marketed to LGBTQIA+ individuals and populations. 6) Additional projects related to LGBTQIA+ health education not otherwise described: There are multiple ongoing projects related to LGBTQIA+ health education and opportunities for students to develop their own project and collaborate with the team based on their own specific interests. ____________________________________________________________________________ Role - The role depends on the specific project, student interest, learning objectives, and student experience but could involve literature reviews, developing and analyzing surveys, CQI root cause analyses, facilitating focus groups, conducting interviews, transcribing records, analyzing existing or newly collected data sets using quantitative or qualitative methods, and/or putting together a reports, manuscripts, and/or presentations of the findings of the specific project. ; IRB Status - TBD. Some projects (e.g. CQI, literature reviews) will not require an IRB, others may be part of a larger ongoing project where an existing IRB needs to be modified. If a new IRB will be required as determined by the nature of the project, our goal will be to have the to be complete by March 2024.; Skills - The learner must demonstrate curiosity, compassion, and critical thinking skills. Must have strong communication and collaboration skills. Previous research experience relevant to the specific project (e.g. Survey design, quantitative data analysis, focus group facilitation, qualitative data analysis, previous CQI work, etc.) is a plus but not required. Projects will be designed to compliment and augment existing skills to promote success. Co-mentors with expertise will be recruited as needed. | Academic Affairs | TBD depending on specific project | Advancing LGBTQIA+ Education, Equity and Support in Academic Medicine | The broad goal of this work is to improve health outcomes and optimizing wellbeing for members of the LGBTQIA+ community through enhancing education and support initiatives in academic medicine. To date, medical and genetic counseling students at SMPH have worked on various projects, from doing a national review of the literature on LGBTQIA+ curriculum in medical schools and examining the content and effectiveness of the SMPH Phase 1 curriculum to understanding how genetic counselors use gender affirming language in health care settings and analyzing how genetic counseling programs across the country prepare learners to care for LGBTQIA+ patents. There are opportunities to do more, building on existing projects or creating a new project with a specific focus to improve knowledge, skills, and services for individuals who identify as LGBTQIA+. Collaborative projects and interprofessional projects are possible depending on student interests. All projects would be developed in close collaboration with the mentor/research team with clear hypotheses, goals, and aims. Some of the potential ideas for projects include, but are not limited to: 1) Unpacking UWSMPH learner experiences with LGBTQIA+ health education through focus groups or surveys: This study could be part of a larger project looking at LGBTQIA+ health education for medical students or could look more broadly at students across different health professions. The primary goal is to gain a better understanding of student experiences learning about LGBTQ+ health within and outside of school, as well as their self-perceived knowledge and readiness to care for LGBTQ+ patients. 2) Exploring medical or other health professional learner experiences at UWSMPH based on gender and/or sexual orientation: This project aims to illuminate experiences of learners throughout their learning at UWSMPH, and in particular will explore how gender, and potentially sexual orientation as well, may impact student experiences. This project can utilize some pre-existing data as well as obtain additional data through focus groups (or another method based on discussion with the student and mentor). 3) Exploring opportunities to learn about LGBTQ+ health in clinical rotations (e.g., phases 2 and 3 for medical students) at UWSMPH. This study could be part of a larger ongoing project looking at LGBTQ+ health education for medical students. The primary goal of this component is to gain a better understanding of opportunities to learn about LGBTQ+ health on clinical rotations (both required and elective, both in Madison and at statewide sites). Similar work could also be done for other health professions clinical rotations (e.g. prenatal clinic for genetic counselors), as part of a residency program or fellowship project, or part of a MPH scholarly project. 3) Doing a comprehensive annotated literature review regarding how medical, public health, and/or health professions schools measure and address bias against LGBTQ+ people among learners: This project involves a methodical and comprehensive literature review on this topic. There is also the possibility to expand this project to consider this topic specifically within UWSMPH educational programs. 4) Understanding experiences of LGBTQIA+ faculty and/or staff in academic medicine regarding their experiences and the impact their gender and/or sexuality impacted their career path, opportunities for promotion, and wellbeing. This could be a narrative story telling project that captures unique perspectives of faculty throughout their careers as a member of the LGBTQIA+ community. 5) Examining pharmaceutical, medical device, reproductive services, and/or clinical service advertisements for LGBTQIA+ representation and inclusion. This would involved a focused rigorous approach to examine how medical services are currently and/or historically marketed to LGBTQIA+ individuals and populations. 6) Additional projects related to LGBTQIA+ health education not otherwise described: There are multiple ongoing projects related to LGBTQIA+ health education and opportunities for students to develop their own project and collaborate with the team based on their own specific interests. | 1 | The role depends on the specific project, student interest, learning objectives, and student experience but could involve literature reviews, developing and analyzing surveys, CQI root cause analyses, facilitating focus groups, conducting interviews, transcribing records, analyzing existing or newly collected data sets using quantitative or qualitative methods, and/or putting together a reports, manuscripts, and/or presentations of the findings of the specific project. | The learner would work independently and serve as the leader of their project. There would be weekly formal meetings with the mentor/co-mentor and the research team. There would be meetings that the student would be expected to attend. A specific timeline of expectations would be developed and individualized for the specific project. | The learner must demonstrate curiosity, compassion, and critical thinking skills. Must have strong communication and collaboration skills. Previous research experience relevant to the specific project (e.g. Survey design, quantitative data analysis, focus group facilitation, qualitative data analysis, previous CQI work, etc.) is a plus but not required. Projects will be designed to compliment and augment existing skills to promote success. Co-mentors with expertise will be recruited as needed. | TBD. Some projects (e.g. CQI, literature reviews) will not require an IRB, others may be part of a larger ongoing project where an existing IRB needs to be modified. If a new IRB will be required as determined by the nature of the project, our goal will be to have the to be complete by March 2024. | Some external funding depending on specific project, discretionary funding from PI will be used to support project. Some other sources of external funds may be available depending on the specific project. | Yes | Yes | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Yes | Yes | Susan Jeannette | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: TBD depending on specific project | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuckVWDcECzJG5iIqdQ9dKyltX2N0j7h31-rdFB9r4Tlnr52AIu3H0lm24QRWjS6wo8 | |||||||
| nahmad@dermatology.wisc.edu | Nihal | Ahmad | PhD | Professor | 608 | Dermatology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Role of SERPINB4 in cutaneous melanoma: Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. While immunotherapies have drastically improved melanoma treatment, most of the patients fail to achieve durable tumor regression and demonstrate metastasis and recurrence due to drug resistance. Thus, new mechanism-based approaches are urgently required for melanoma management. Novel immune-related targets hold promise to improve melanoma treatment and patient survival. Using the bioinformatics approach, we previously identified key immune-related molecules that are differentially expressed in metastatic melanoma and have a significant correlation with patient survival. Further, employing multiple melanoma cell lines we found that SERPINB4 (Squamous Cell Carcinoma Antigen 2 or SCCA2), a serine protease inhibitor, is significantly overexpressed in melanoma and enhanced cell proliferation. However, the exact role and immune-related mechanisms associated with SERPINB4 are not known in melanoma. Interestingly, SERPINB4 has been shown to regulate the host immune response against tumor cells by inhibiting granzyme M (GrM) activity. In this project, we will determine the effects of forced overexpression and knockout of SERPINB4 in multiple melanoma cell lines. Specifically, we will determine the effects of SERPINB4 modulation on colony formation, cell cycle, migration, and invasion as well as on markers of proliferation and survival. In addition, we will determine the immune evasion mechanisms of SERPINB4 against GrM-induced cell death. ____________________________________________________________________________ Role - Student will work in the project and study the role and functional significance of SERPINB4 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cell lines, cell cycle analysis, clonogenic survival, invasion and migration assays, as well as RT-qPCR and Simple Western techniques for gene and protein expression analyses.; IRB Status - N/A; Skills - Knowledge of cell culture and basic laboratory techniques is preferred but not required. | Gagan Chhabra | gchhabra@dermatology.wisc.edu | Dermatology | Role of SERPINB4 in cutaneous melanoma | Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. While immunotherapies have drastically improved melanoma treatment, most of the patients fail to achieve durable tumor regression and demonstrate metastasis and recurrence due to drug resistance. Thus, new mechanism-based approaches are urgently required for melanoma management. Novel immune-related targets hold promise to improve melanoma treatment and patient survival. Using the bioinformatics approach, we previously identified key immune-related molecules that are differentially expressed in metastatic melanoma and have a significant correlation with patient survival. Further, employing multiple melanoma cell lines we found that SERPINB4 (Squamous Cell Carcinoma Antigen 2 or SCCA2), a serine protease inhibitor, is significantly overexpressed in melanoma and enhanced cell proliferation. However, the exact role and immune-related mechanisms associated with SERPINB4 are not known in melanoma. Interestingly, SERPINB4 has been shown to regulate the host immune response against tumor cells by inhibiting granzyme M (GrM) activity. In this project, we will determine the effects of forced overexpression and knockout of SERPINB4 in multiple melanoma cell lines. Specifically, we will determine the effects of SERPINB4 modulation on colony formation, cell cycle, migration, and invasion as well as on markers of proliferation and survival. In addition, we will determine the immune evasion mechanisms of SERPINB4 against GrM-induced cell death. | 1 | Student will work in the project and study the role and functional significance of SERPINB4 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cell lines, cell cycle analysis, clonogenic survival, invasion and migration assays, as well as RT-qPCR and Simple Western techniques for gene and protein expression analyses. | Knowledge of cell culture and basic laboratory techniques is preferred but not required. | N/A | Yes | Yes | Yes | PhD students | Unsure / Depends | No | Mary Gannon, mgannon@dermatology.wisc.edu | Nihal Ahmad, nahmad@dermatology.wisc.edu -- Co-Mentor: Gagan Chhabra gchhabra@dermatology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucC6Qm_tJd4RAmC9mP3qPhIxS-Pq_e_K8rYUwtd5tY3JspCbH7_n_AMUorQklylF5c | |||||||
| agepner@medicine.wisc.edu | Adam | Gepner | MD | Associate Professor of Medicine | 6.085.778.048 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Building a Successful Virtual Fitness Program for Older Adults (GeroFit Madison): This is a retrospective analysis of comparing health and fitness metrics in participants of the Gerofit Madison program compared with Veterans who participate in the Gerofit Madison Program for < 6 months or who observed the program but chose not to participate. Physical activity declines as we age and studies suggest that only 15% of adults over 65 years engage in regular physical activity. Lower levels of physical activity have been associated with functional and cognitive disability and poor health outcomes, specifically higher risk of cardiovascular disease events, frailty, and falls, all which can be improved with regular physical activity. Despite the well-established benefits of physical activity8 and advances in mobile health and telehealth technology, the use and the benefits of a virtual exercise program in older Veterans are lacking. Gerofit is a national VA exercise program that promotes physical and mental health and wellness for Veterans. Gerofit was designed to help Veterans stay active by improving or minimizing losses in strength, balance, flexibility and cardiovascular fitness. Veterans are provided with personalized exercise prescriptions by trained staff (exercise physiologists, nurses and physical therapists). Gerofit was started at the Durham VA in 1986, the program is now offered at 31 different VA Healthcare Systems around the country. The Madison VA hosts the largest and fastest growing Virtual Gerofit program in the country with ~ 200 regular participants. We plan a retrospective analysis of comparing health and fitness metrics and frailty outcomes in participants of the Gerofit Madison program (an all-virtual ongoing exercise program for Veterans over age 65) compared with age and sex matched Veterans who enroll in the program but stop attending within 6 months or who observe the program but elect not to participate. This study will compare anthropomorphic, laboratory data, functional metrics (sit to stand testing, arm curls, etc) and frailty markers in Gerofit participants compared to age and sex matched non-Gerofit participants. ____________________________________________________________________________ Role - A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevant topics including cardiovascular disease prevention, exercise and frailty. 2. Review and understand the Gerofit protocol and study techniques and limitations involved in retrospective analysis. 3. Review and analyze data. 4. Compose a research proposal/abstract/poster/manuscript; IRB Status - Approved; Skills - Skills with excel and powerpoint are helpful but not required. Some statistical and programming background is helpful but not required. | Cardiovascular Medicine | Medicine | Geriatrics and Gerontology | Building a Successful Virtual Fitness Program for Older Adults (GeroFit Madison) | This is a retrospective analysis of comparing health and fitness metrics in participants of the Gerofit Madison program compared with Veterans who participate in the Gerofit Madison Program for < 6 months or who observed the program but chose not to participate. Physical activity declines as we age and studies suggest that only 15% of adults over 65 years engage in regular physical activity. Lower levels of physical activity have been associated with functional and cognitive disability and poor health outcomes, specifically higher risk of cardiovascular disease events, frailty, and falls, all which can be improved with regular physical activity. Despite the well-established benefits of physical activity8 and advances in mobile health and telehealth technology, the use and the benefits of a virtual exercise program in older Veterans are lacking. Gerofit is a national VA exercise program that promotes physical and mental health and wellness for Veterans. Gerofit was designed to help Veterans stay active by improving or minimizing losses in strength, balance, flexibility and cardiovascular fitness. Veterans are provided with personalized exercise prescriptions by trained staff (exercise physiologists, nurses and physical therapists). Gerofit was started at the Durham VA in 1986, the program is now offered at 31 different VA Healthcare Systems around the country. The Madison VA hosts the largest and fastest growing Virtual Gerofit program in the country with ~ 200 regular participants. We plan a retrospective analysis of comparing health and fitness metrics and frailty outcomes in participants of the Gerofit Madison program (an all-virtual ongoing exercise program for Veterans over age 65) compared with age and sex matched Veterans who enroll in the program but stop attending within 6 months or who observe the program but elect not to participate. This study will compare anthropomorphic, laboratory data, functional metrics (sit to stand testing, arm curls, etc) and frailty markers in Gerofit participants compared to age and sex matched non-Gerofit participants. | 0 | A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevant topics including cardiovascular disease prevention, exercise and frailty. 2. Review and understand the Gerofit protocol and study techniques and limitations involved in retrospective analysis. 3. Review and analyze data. 4. Compose a research proposal/abstract/poster/manuscript | The scholar should be comfortable working independently and with our research team | Skills with excel and powerpoint are helpful but not required. Some statistical and programming background is helpful but not required. | Approved | Yes | Yes | Yes | DPT students, MPH students | No | No | Amy Hein - Amy.Hein@va.gov | Adam Gepner, agepner@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuciIVIjUvlkmFLBWJjOJhHk8sL_uPaPQa9hW5GpT1T490myzrEC_E8QqtqoQRxL0Q0 | ||||||
| apeterson@pediatrics.wisc.edu | Amy | Peterson | MD, MS | Professor (CHS) of Pediatrics | 608 | Pediatrics | Shorter term projects | Impact of Guidelines on Pediatric Cholesterol Screening: The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team has evaluated children with both genetic and environmental causes of dyslipidemia. In 2011, guidelines were released recommending all children have their cholesterol checked in order to screen for genetic dyslipidemia. Nationally, adherence to the guideline has been low, but UW Health reports the highest published rates of pediatric cholesterol screening in the United States to date. In August 2023, the United States Preventive Services Task Force released guidance on universal pediatric cholesterol screening, giving it an “I” recommendation, indicating that there is insufficient evidence to assess potential benefits and harms. The impact of this guideline recommendation on pediatric cholesterol screening is unknown. Our team proposes to measure pediatric cholesterol screening rates from 6/2023-6/2024 within UW Health and evaluate for differences based on patient age, sex, geographical location, and other factors. https://www.pediatrics.wisc.edu/research/research-groups/peterson/ ____________________________________________________________________________ Role - Collaborate with the PPCC research team to query Health Link, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinics as desired.; IRB Status - An IRB protocol is already in place for this project. ; Skills - None | Pediatric Cardiology | Xiao Zhang, PhD, Research Scientist | xiao.zhang@wisc.edu | Pediatrics | Pediatric Cardiology | Impact of Guidelines on Pediatric Cholesterol Screening | The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team has evaluated children with both genetic and environmental causes of dyslipidemia. In 2011, guidelines were released recommending all children have their cholesterol checked in order to screen for genetic dyslipidemia. Nationally, adherence to the guideline has been low, but UW Health reports the highest published rates of pediatric cholesterol screening in the United States to date. In August 2023, the United States Preventive Services Task Force released guidance on universal pediatric cholesterol screening, giving it an “I” recommendation, indicating that there is insufficient evidence to assess potential benefits and harms. The impact of this guideline recommendation on pediatric cholesterol screening is unknown. Our team proposes to measure pediatric cholesterol screening rates from 6/2023-6/2024 within UW Health and evaluate for differences based on patient age, sex, geographical location, and other factors. https://www.pediatrics.wisc.edu/research/research-groups/peterson/ | 0 | Collaborate with the PPCC research team to query Health Link, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinics as desired. | This project requires a self-motivated learner and strong work ethic, but the research team will provide support for this project. | None | An IRB protocol is already in place for this project. | No | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, UW undergraduates interested in research | No | Yes | Xiao Zhang xiao.zhang@wisc.edu | Amy Peterson, apeterson@pediatrics.wisc.edu -- Co-Mentor: Xiao Zhang, PhD, Research Scientist xiao.zhang@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufyTpF8-yxjupW91pu7slv-FIarZNFrFz2WbG2qhBZrXv39wYzQalqLbvkMx-kDbes | ||||
| 12/01/2023 | mtlong@wisc.edu | Micah | Long | MD | Associate Professor | 920 | Anesthesiology | Shorter term projects, Research Electives for credit | Calcium in In-Hospital Cardiac Arrest: The American Heart Association does not recommend the use of calcium in cardiac arrest, based on leading data from out-of-hospital cardiac arrest, where calcium use was associated with increased mortality. Nonetheless, for in-hospital cardiac arrest, etiologies of arrest are different, including an increased incidence of hyperkalemia and hypotension, where calcium may be of benefit. Accordingly, calcium is used extensively (in >25% of arrests at many hospitals) and broadly (at many different hospitals). We will perform a retrospective cohort study comparing time-stratified outcomes for patients who had in-hospital arrest, assessing those who received calcium, versus those who didn't. This will require review of code sheets, data input, chart review and validation of an IT export of EMR data. This is in final IRB review for multi-center assessment with 4 other hospitals participating. ____________________________________________________________________________ Role - Data review of code outcomes including review of code sheets. Integrate multi-center effort / review other center's data input in Redcap. If data review is completed, work with statistics, data review and prepare manuscript for submission.; IRB Status - completed IRB; Skills - EMR review | Critical Care | Medicine | Critical Care | John Dollerschell | dollerschell@wisc.edu | Anesthesiology | Critical Care | Calcium in In-Hospital Cardiac Arrest | The American Heart Association does not recommend the use of calcium in cardiac arrest, based on leading data from out-of-hospital cardiac arrest, where calcium use was associated with increased mortality. Nonetheless, for in-hospital cardiac arrest, etiologies of arrest are different, including an increased incidence of hyperkalemia and hypotension, where calcium may be of benefit. Accordingly, calcium is used extensively (in >25% of arrests at many hospitals) and broadly (at many different hospitals). We will perform a retrospective cohort study comparing time-stratified outcomes for patients who had in-hospital arrest, assessing those who received calcium, versus those who didn't. This will require review of code sheets, data input, chart review and validation of an IT export of EMR data. This is in final IRB review for multi-center assessment with 4 other hospitals participating. | 0 | Data review of code outcomes including review of code sheets. Integrate multi-center effort / review other center's data input in Redcap. If data review is completed, work with statistics, data review and prepare manuscript for submission. | Mostly computer work, will need lots of mentorship but can be quite independent. | EMR review | completed IRB | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan, PhD jasullivan@wisc.edu | Micah Long, mtlong@wisc.edu -- Co-Mentor: John Dollerschell dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucmU2ggmjySad0ei12wFKFR11KwecwXrp-IAn7mq-3pU1ynin17IM6qCukIxClNEAo | |
| 12/01/2023 | richards@urology.wisc.edu | Kyle | Richards | MD FACS | Associate Professor | 608 | Urology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Bladder cancer research: I have worked with Shapiro medical students for the past 9 summers. We tailor the project to the student's goals. My group does a variety of health services research involving patient's with bladder cancer. Many of my students have gone on to publish their work. My students spend time with me in clinic and in the operating room observing cutting edge robotic surgery. If you want to discuss further and learn about more specific research projects, feel free to email me. ____________________________________________________________________________ Role - Some data collection and analysis. Manuscript preparation.; IRB Status - Completed; Skills - None | Urologic Oncology | Bladder cancer research | I have worked with Shapiro medical students for the past 9 summers. We tailor the project to the student's goals. My group does a variety of health services research involving patient's with bladder cancer. Many of my students have gone on to publish their work. My students spend time with me in clinic and in the operating room observing cutting edge robotic surgery. If you want to discuss further and learn about more specific research projects, feel free to email me. | 0 | Some data collection and analysis. Manuscript preparation. | Moderate | None | Completed | No | Yes | Yes | Not currently available to mentor other students | No | Yes | Steve Hall (DA) and Denise Musehl and Anna Peacock | Kyle Richards, richards@urology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnues7ssoWY1sIuCcu_va29KukIwuh5ZrsinVc9aYShGLi_UmjZ3C0bMoTRKIK4XzHUc | |||||||
| afowler@wisc.edu | Amy | Fowler | MD, PhD | Associate Professor | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Breast Imaging in the Pediatric Population: The project consists of a literature review culminating in an image-rich manuscript of breast imaging in the pediatric population. The manuscript will focus on 1) the appropriate imaging evaluation and management of symptomatic breast issues in the pediatric population, 2) imaging findings of normal breast development and normal variants, and 3) differential diagnoses for breast masses in neonates, children, and adolescents. This project will result in a peer-reviewed manuscript publication and would be beneficial for individuals interested in pursuing radiology residency or pediatric residency. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ ____________________________________________________________________________ Role - Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of symptomatic breast issues in the pediatric population. Images from case examples have been collected and will need to be organized as figures in the manuscript.; IRB Status - N/A; Skills - Strong work ethic, reliability, organization, and enthusiasm for the project. | Breast Imaging and Intervention | Medical Physics | Breast Imaging in the Pediatric Population | The project consists of a literature review culminating in an image-rich manuscript of breast imaging in the pediatric population. The manuscript will focus on 1) the appropriate imaging evaluation and management of symptomatic breast issues in the pediatric population, 2) imaging findings of normal breast development and normal variants, and 3) differential diagnoses for breast masses in neonates, children, and adolescents. This project will result in a peer-reviewed manuscript publication and would be beneficial for individuals interested in pursuing radiology residency or pediatric residency. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ | 0 | Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of symptomatic breast issues in the pediatric population. Images from case examples have been collected and will need to be organized as figures in the manuscript. | A moderate degree of independence is required for completion of this project. | Strong work ethic, reliability, organization, and enthusiasm for the project. | N/A | Current funding is unrelated to this project. | Department of Radiology | Yes | PhD students, UW undergraduates interested in research | Yes | No | Lorene Seman: LSeman@uwhealth.org | Amy Fowler, afowler@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf2sme7H055DqiYPuZwsqh4ry8zOiGa2GSqs-51DCe-hFnZdNwNAcO11IaG4pTLSHQ | ||||||||
| 12/03/2023 | mpuricelli@wisc.edu | Mike | Puricelli | MD | Assistant Professor of Surgery (Otolaryngology Head & Neck Surgery) and Pediatrics | Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Newborn Hearing Screening Performance and Process Optimization: "Newborn Hearing Screening Performance and Process Optimization" Wisconsin Sound Beginnings (WSB) is Wisconsin's Early Hearing Detection and Intervention (EHDI) program, ensuring that all babies born in the state are screened for hearing loss, receive timely diagnosis of hearing loss and receive quality early intervention. These steps are critical for optimal speech and language development and align with the Joint Committee on Infant Hearing's 1-3-6 model: babies are screened by 1 month of age; diagnosed by 3 months of age; and receive early intervention services by 6 months of age. Unfortunately, disparities in screening, diagnosis, and intervention exist. This project involves participation in a multidisciplinary collaborative effort (Ped ENT, Neonatology, Audiology, WI Sound Beginnings Team) to: 1. Assess of performance of UW facilities compared to peer and state benchmarks with submission of a paper outlining performance, opportunities, and best practices to a peer reviewed journal (WI sound beginnings WE-TRAC program will be the data source) 2. Design and participate in a quality improvement project to increase the compliance at UW facilities 3. Participate in additional research and quality improvement efforts with the team that could include but are not limited to (a) examination of population/sociodemographic/native language sources of disparity, (b) development of an evaluation and management protocol for complications of acute otitis media such as acute mastoiditis, (c) examination of disparities in ear reconstructive surgery outcomes among healthy vs medically complex pediatric patients, and (d) develop and participate in a case review process for UW newborn hearing screening, diagnosis and intervention referral. ____________________________________________________________________________ Role - Please see above; IRB Status - Data is de-identified and would be IRB exempt.; Skills - Motivation and interest to learn are the most important things that you can bring. I intend to develop a longitudinal mentorship relationship with the successful candidate that would include ongoing research collaboration after completion of the project. | Otolaryngology | Pediatrics | Newborn Hearing Screening Performance and Process Optimization | "Newborn Hearing Screening Performance and Process Optimization" Wisconsin Sound Beginnings (WSB) is Wisconsin's Early Hearing Detection and Intervention (EHDI) program, ensuring that all babies born in the state are screened for hearing loss, receive timely diagnosis of hearing loss and receive quality early intervention. These steps are critical for optimal speech and language development and align with the Joint Committee on Infant Hearing's 1-3-6 model: babies are screened by 1 month of age; diagnosed by 3 months of age; and receive early intervention services by 6 months of age. Unfortunately, disparities in screening, diagnosis, and intervention exist. This project involves participation in a multidisciplinary collaborative effort (Ped ENT, Neonatology, Audiology, WI Sound Beginnings Team) to: 1. Assess of performance of UW facilities compared to peer and state benchmarks with submission of a paper outlining performance, opportunities, and best practices to a peer reviewed journal (WI sound beginnings WE-TRAC program will be the data source) 2. Design and participate in a quality improvement project to increase the compliance at UW facilities 3. Participate in additional research and quality improvement efforts with the team that could include but are not limited to (a) examination of population/sociodemographic/native language sources of disparity, (b) development of an evaluation and management protocol for complications of acute otitis media such as acute mastoiditis, (c) examination of disparities in ear reconstructive surgery outcomes among healthy vs medically complex pediatric patients, and (d) develop and participate in a case review process for UW newborn hearing screening, diagnosis and intervention referral. | 0 | Please see above | Mentorship will be provided in all aspects of the effort. A team of state leaders, state data experts, neonatology faculty, audiology faculty, otolaryngology faculty and and otolaryngology resident will be collaborating with you. | Motivation and interest to learn are the most important things that you can bring. I intend to develop a longitudinal mentorship relationship with the successful candidate that would include ongoing research collaboration after completion of the project. | Data is de-identified and would be IRB exempt. | No | Yes | Yes | MPH students, PhD students | No | Yes | N/A | Mike Puricelli, mpuricelli@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuefU34mY4pRdQ7bsjnnhvMvrkIhLaDkugC_PYbD0DpLNR2un4pUjeWexsXWFvSHF8o | |||||||
| 12/04/2023 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Chair | 608 | Neurological Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experience some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native Americans have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. ____________________________________________________________________________ Role - MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations and will evaluate change over a two-year time period looking at how health wellness coaching is related to modifying stroke risk factors.; IRB Status - Approved; Skills - Curious / multitasking / willing to learn new skills / teamwork | SMPH | Carol C. Mitchell, PhD | ccm@medicine.wisc.edu | Medicine | Cardiovascular | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation | American Indian/Alaska Native (AI/AN) populations across the country experience some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native Americans have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. | 0 | MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations and will evaluate change over a two-year time period looking at how health wellness coaching is related to modifying stroke risk factors. | Curious / multitasking / willing to learn new skills / teamwork | Approved | No | Yes | Yes | Not currently available to mentor other students | Yes | Yes | Stephanie Wilbrand, PhD - wilbrand@neurosurgery.wisc.edu Niki Virnig - virnig@neurosurgery.wisc.edu | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Carol C. Mitchell, PhD ccm@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuesufvSqLiFSyJUIfRB1j4uGlt8TAJcHUl2Z7Uutma2JFXrN0WB8d6DaDA_L9BGAlY | ||||
| 12/04/2023 | ccm@medicine.wisc.edu | Carol | Mitchell | PhD | Associate Professor | 608 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Ultrasound Biomarkers in Stroke Prevention in the Oneida Nation Change over Two-years: 1. Background and Significance Native Americans have lived with significant health disparities since the arrival of the Europeans. These health disparities have taken on different forms over the past centuries and are still evident today (1). Despite disproportionate prevalence of cardiovascular disease and stroke, there is a relatively small pool of literature that aim to cover such topics (1). Native Americans have a higher prevalence of controllable risk factors for cardiovascular disease such as diabetes mellitus, hypertension, and obesity. Likewise, a genome-wide scan found that they have several genetic predispositions that place them at a higher risk for developing those risk factors (3). As a result of these factors, Native Americans risk for stroke is triple the rate compared to the white population. The risk factors of stroke have been well documented in literature, but the process that leads to stroke is much more insidious. The development of carotid atherosclerosis is recognized as a factor that can lead to stroke and decreased cognitive function. The formation of plaques in the carotid arteries can potentially lead to narrowing of lumen and result in a decreased blood flow. Similarly, the rupture of plaques may elicit microemboli being released in carotid arteries which may lodge in microvasculature in the brain leading to ischemia. The spectrum of carotid atherosclerosis is a marker of the severity of plaque instability and predictability of emboli formation (3-9). Current targeted interventions to reduce the occurrence of stroke involve managing blood pressure, cholesterol, and the use of anticoagulants. Identification of carotid atherosclerosis in its earliest stages could contribute to earlier treatment and reduce mortality. Texture features of the plaque and plaque-free segments of the arterial wall and plaque area have been shown to be associated with cardiovascular disease risk factors and may change as risk factors change. The utilization of ultrasound provides a feasible mechanism to assess arterial injury in asymptomatic patients (3-9). 2. Hypothesis or Research Question This project will focus on the relationship of change in ultrasound biomarkers biomarkers in the carotid arteries to change in stroke risk factors and cognitive performance. We will examine the relationships of change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid artery and internal carotid arteries) to stroke risk factors and cognitive tests. We hypothesize that early recognition of ultrasound biomarkers and interventional coaching will reduce plaque area, decrease pulsatility index and increase end-diastolic velocities in the common and internal carotid arteries. Specific Aims 1. Determine how change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid and internal carotid arteries) are related to change in stroke risk factors 2. Determine how change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid and internal carotid arteries) are related to cognitive performance 3. Research Design and Methods This study includes 120 participants, ages 55 to 80, from the Oneida Nation enrolled in the “Stroke Prevention in the Wisconsin Native America Population,” (ClinicalTrials.gov ID NCT04382963). Participants were 20 low-risk control participants and 100 high risk for stroke participants. Low risk was defined as age 55 years and fewer than three risk factors for stroke, high risk was defined as age 55 years and 3 or more risk factors for stroke. High risk participants were randomized into two groups (group 1 standard treatment for stroke risk factors and group 2 standard risk factors for treatment of stroke risk factors and intensive health wellness coaching). Baseline ultrasound biomarkers (plaque area, pulsatility index and end-diastolic value) will be evaluated at baseline and year 2 of the study. A change variable will be calculated for each (Year 2 value – Baseline value) and the change in ultrasound biomarkers will be correlated with change in stroke risk factor (systolic blood pressure, diastolic blood pressure, body-mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, triglycerides, and hemoglobin A1c). Independent T-tests will be used to examine differences between the high risk groups. If data is not normally distributed non-parametric testing will be used to examine differences between groups. ____________________________________________________________________________ Role - The student role is to actively participate in the stroke prevention community at the Oneida Nation. The student will be responsible for reviewing relevant literature on the topics of ultrasound and stroke prevention and observe and assist with carotid ultrasound examinations and gain an appreciation for its non-invasive, preventative capabilities for measuring several characteristics of carotid plaques. Additionally, the student will learn to review ultrasound imaging, with a specific focus on the measures noted in this study. ; IRB Status - Approved; Skills - Curious / multitasking / willing to learn new skills / teamwork | Cardiovascular | Robert J. Dempsey, MD | dempsey@neurosurgery.wisc.edu | Neurological Surgery | SMPH | Ultrasound Biomarkers in Stroke Prevention in the Oneida Nation Change over Two-years | 1. Background and Significance Native Americans have lived with significant health disparities since the arrival of the Europeans. These health disparities have taken on different forms over the past centuries and are still evident today (1). Despite disproportionate prevalence of cardiovascular disease and stroke, there is a relatively small pool of literature that aim to cover such topics (1). Native Americans have a higher prevalence of controllable risk factors for cardiovascular disease such as diabetes mellitus, hypertension, and obesity. Likewise, a genome-wide scan found that they have several genetic predispositions that place them at a higher risk for developing those risk factors (3). As a result of these factors, Native Americans risk for stroke is triple the rate compared to the white population. The risk factors of stroke have been well documented in literature, but the process that leads to stroke is much more insidious. The development of carotid atherosclerosis is recognized as a factor that can lead to stroke and decreased cognitive function. The formation of plaques in the carotid arteries can potentially lead to narrowing of lumen and result in a decreased blood flow. Similarly, the rupture of plaques may elicit microemboli being released in carotid arteries which may lodge in microvasculature in the brain leading to ischemia. The spectrum of carotid atherosclerosis is a marker of the severity of plaque instability and predictability of emboli formation (3-9). Current targeted interventions to reduce the occurrence of stroke involve managing blood pressure, cholesterol, and the use of anticoagulants. Identification of carotid atherosclerosis in its earliest stages could contribute to earlier treatment and reduce mortality. Texture features of the plaque and plaque-free segments of the arterial wall and plaque area have been shown to be associated with cardiovascular disease risk factors and may change as risk factors change. The utilization of ultrasound provides a feasible mechanism to assess arterial injury in asymptomatic patients (3-9). 2. Hypothesis or Research Question This project will focus on the relationship of change in ultrasound biomarkers biomarkers in the carotid arteries to change in stroke risk factors and cognitive performance. We will examine the relationships of change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid artery and internal carotid arteries) to stroke risk factors and cognitive tests. We hypothesize that early recognition of ultrasound biomarkers and interventional coaching will reduce plaque area, decrease pulsatility index and increase end-diastolic velocities in the common and internal carotid arteries. Specific Aims 1. Determine how change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid and internal carotid arteries) are related to change in stroke risk factors 2. Determine how change in ultrasound biomarkers (plaque area, pulsatility index and end-diastolic velocity in the distal common carotid and internal carotid arteries) are related to cognitive performance 3. Research Design and Methods This study includes 120 participants, ages 55 to 80, from the Oneida Nation enrolled in the “Stroke Prevention in the Wisconsin Native America Population,” (ClinicalTrials.gov ID NCT04382963). Participants were 20 low-risk control participants and 100 high risk for stroke participants. Low risk was defined as age 55 years and fewer than three risk factors for stroke, high risk was defined as age 55 years and 3 or more risk factors for stroke. High risk participants were randomized into two groups (group 1 standard treatment for stroke risk factors and group 2 standard risk factors for treatment of stroke risk factors and intensive health wellness coaching). Baseline ultrasound biomarkers (plaque area, pulsatility index and end-diastolic value) will be evaluated at baseline and year 2 of the study. A change variable will be calculated for each (Year 2 value – Baseline value) and the change in ultrasound biomarkers will be correlated with change in stroke risk factor (systolic blood pressure, diastolic blood pressure, body-mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, triglycerides, and hemoglobin A1c). Independent T-tests will be used to examine differences between the high risk groups. If data is not normally distributed non-parametric testing will be used to examine differences between groups. | 0 | The student role is to actively participate in the stroke prevention community at the Oneida Nation. The student will be responsible for reviewing relevant literature on the topics of ultrasound and stroke prevention and observe and assist with carotid ultrasound examinations and gain an appreciation for its non-invasive, preventative capabilities for measuring several characteristics of carotid plaques. Additionally, the student will learn to review ultrasound imaging, with a specific focus on the measures noted in this study. | Curious / multitasking / willing to learn new skills / teamwork | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | Stephanie Wilbrand, PhD - wilbrand@neurosurgery.wisc.edu Calleen Roper - croper@medicine.wisc.edu | Carol Mitchell, ccm@medicine.wisc.edu -- Co-Mentor: Robert J. Dempsey, MD dempsey@neurosurgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueGBpgmEUHDcOD8m17Eg27R9oS_L2G26dY6AsHG9YG7UMocVODRxzzDZHCewHBVAnI | ||||
| 12/04/2023 | calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | 6.084.179.953 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Relationship between Central Line Associated Bloodstream Infection rate and Line Maintenance Bundle Compliance At American Family Children's Hospital: Central Line Associated Bloodstream Infections (CLABSIs) are the most expensive hospital acquired condition and are used as a proxy for the overall quality of care delivered by hospitals. For this project, we would like to analyze several years' worth of data (already collected) of compliance to central line care bundles and how those rates do or not correspond to overall CLABSI rates. We believe that paradoxically, the lower compliance documented to our standard of care bundles will be related to lower CLABSI rates. In other words, if bundle compliance is not thoroughly audited and boxes are checked without complete verification, it will make our bundle compliance look higher but actually lead to more CLABSI events. ____________________________________________________________________________ Role - analyzing several years' worth of bundle compliance data from each unit that cares for patients with central lines at AFCH and comparing compliance rates with CLABSI rates. All data are already collected so no data collection is required; IRB Status - I will work with student to obtain IRB exemption since this is QI work; Skills - data analysis, basic statistics, excellent communication skills | Pediatric Hematology/Oncology | Relationship between Central Line Associated Bloodstream Infection rate and Line Maintenance Bundle Compliance At American Family Children's Hospital | Central Line Associated Bloodstream Infections (CLABSIs) are the most expensive hospital acquired condition and are used as a proxy for the overall quality of care delivered by hospitals. For this project, we would like to analyze several years' worth of data (already collected) of compliance to central line care bundles and how those rates do or not correspond to overall CLABSI rates. We believe that paradoxically, the lower compliance documented to our standard of care bundles will be related to lower CLABSI rates. In other words, if bundle compliance is not thoroughly audited and boxes are checked without complete verification, it will make our bundle compliance look higher but actually lead to more CLABSI events. | 0 | analyzing several years' worth of bundle compliance data from each unit that cares for patients with central lines at AFCH and comparing compliance rates with CLABSI rates. All data are already collected so no data collection is required | whatever the student needs | data analysis, basic statistics, excellent communication skills | I will work with student to obtain IRB exemption since this is QI work | No | should be paid for by department of pediatrics | Yes | Not currently available to mentor other students | No | Yes | Kirsten Koffarnus (kkoffarnus@uwhealth.org) | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudQQDEL_a9le2ydCW53nFTjZJN0QCzxA1OG6reXsV7_yav0ppYRbsDqTgB1lQIrkIQ | |||||||
| 12/05/2023 | khoppe2@wisc.edu | Kara | Hoppe | DO, MS | Associate Professor | 608 | Obstetrics & Gynecology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Cardiovascular/Hypertensive Disorders in Young Adults and Pregnancy/Postpartum: https://www.obgyn.wisc.edu/stac https://clinicaltrials.gov/study/NCT03158051?term=MyHypertension%20Education%20Reaching%20Target&rank=4 Hoppe KK, Smith M, Birstler J, Kim K, Sullivan-Vedder L, LaMantia JN, Knutson Sinaise MR, Swenson M, Fink J, Haggart R, McBride P, Lauver DR, Johnson HM. Effect of a Telephone Health Coaching Intervention on Hypertension Control in Young Adults: The MyHEART Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 1;6(2):e2255618. doi: 10.1001/jamanetworkopen.2022.55618. PMID: 36735261; PMCID: PMC9898821. https://clinicaltrials.gov/study/NCT05685251?term=MyHypertension%20Education%20Reaching%20Target&rank=1 Our lab studies hypertension in young adults, pregnant and postpartum people. The MyHEART trial is complete, however, we have secondary analysis data to complete more manuscripts. The STAC-MyHEARTp study is on-going and we have the ability to incorporate a student in study conduct, with the opportunity to have a side-project and complete a manuscript. Both projects are IRB approved and ready to on-board a student without delay. Other project opportunities could be discussed as desired. ____________________________________________________________________________ Role - Assistance to conducting a clinical trial, including conducting research participant visits, learning about motivational interviewing and health coaching, learning and conducting 24-hour ambulatory blood pressure monitoring, learning how to analyze existing data sets and preparation of manuscripts with the potential to present at a national meeting.; IRB Status - Approved; Skills - None | Maternal Fetal Medicine | Megan Knutson Sinaise | mknutson2@wisc.edu | Obstetrics & Gynecology | Maternal Fetal Medicine | Cardiovascular/Hypertensive Disorders in Young Adults and Pregnancy/Postpartum | https://www.obgyn.wisc.edu/stac https://clinicaltrials.gov/study/NCT03158051?term=MyHypertension%20Education%20Reaching%20Target&rank=4 Hoppe KK, Smith M, Birstler J, Kim K, Sullivan-Vedder L, LaMantia JN, Knutson Sinaise MR, Swenson M, Fink J, Haggart R, McBride P, Lauver DR, Johnson HM. Effect of a Telephone Health Coaching Intervention on Hypertension Control in Young Adults: The MyHEART Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 1;6(2):e2255618. doi: 10.1001/jamanetworkopen.2022.55618. PMID: 36735261; PMCID: PMC9898821. https://clinicaltrials.gov/study/NCT05685251?term=MyHypertension%20Education%20Reaching%20Target&rank=1 Our lab studies hypertension in young adults, pregnant and postpartum people. The MyHEART trial is complete, however, we have secondary analysis data to complete more manuscripts. The STAC-MyHEARTp study is on-going and we have the ability to incorporate a student in study conduct, with the opportunity to have a side-project and complete a manuscript. Both projects are IRB approved and ready to on-board a student without delay. Other project opportunities could be discussed as desired. | 0 | Assistance to conducting a clinical trial, including conducting research participant visits, learning about motivational interviewing and health coaching, learning and conducting 24-hour ambulatory blood pressure monitoring, learning how to analyze existing data sets and preparation of manuscripts with the potential to present at a national meeting. | Moderate, after appropriate training | None | Approved | Yes | Yes | Yes | MPH students, PhD students | No | Yes | Heidi Janzen, Amanda Wildenberg | Kara Hoppe, khoppe2@wisc.edu -- Co-Mentor: Megan Knutson Sinaise mknutson2@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucJqXCeU---mQv-OWxTrs2DY--XreIjG7um34hKCHwPYS8-oXLMI2ykbvJUYRY4yX8 | |||
| 12/05/2023 | bernardoni@medicine.wisc.edu | Brittney | Bernardoni | MD | Dr. | Emergency Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Med Flight Pre-hospital Sedation Practices: A significant number of patients transported by Med Flight require sedation and analgesia to sllow for optimal ventilatory support, decrease sympathetic tone, and ensure patient and provider safety while delivering care. There are evidence-based guidelines for management of sedation in the ICU, but very little research exists on the use of analogosedation for patients in the prehospital setting or during transport. This study will evaluate analogosedation practices for patients with an advanced airway transported by UW Med Flight over a 2 year period. Primary objective is to identify which medications, medication dose, and method of administration (infusion vs bolus) are used, with secondary objective to determine factors that affect choice of sedation agent, choice of administration method, and rate of adverse events as well as rate of adverse events stratified by choice of agent and method of administration. Once completed, this work will lead to the development of a quality improvement initiative to optimize pre-hospital patient care. ____________________________________________________________________________ Role - Pulling data from pre-hospital chart, work with mentor to develop specific question(s)/metric(s) of interest to student, design analysis plan in conjunction with mentor/biostatisics personnel, write/submit to national conference or journal (helicopter emergency medical services (HEMS), emergency medicine, quality, or critical care depending on interest/project goal chosen). Option for involvement in development of QI initiative if interested. ; IRB Status - Under Review, expect approval early 2024; Skills - None required, will mentor. Engaged and willing to learn/work hard towards completion of meaningful research. | Anesthesiology | Craig Tschautscher, MD | Emergency Medicine | Med Flight Pre-hospital Sedation Practices | A significant number of patients transported by Med Flight require sedation and analgesia to sllow for optimal ventilatory support, decrease sympathetic tone, and ensure patient and provider safety while delivering care. There are evidence-based guidelines for management of sedation in the ICU, but very little research exists on the use of analogosedation for patients in the prehospital setting or during transport. This study will evaluate analogosedation practices for patients with an advanced airway transported by UW Med Flight over a 2 year period. Primary objective is to identify which medications, medication dose, and method of administration (infusion vs bolus) are used, with secondary objective to determine factors that affect choice of sedation agent, choice of administration method, and rate of adverse events as well as rate of adverse events stratified by choice of agent and method of administration. Once completed, this work will lead to the development of a quality improvement initiative to optimize pre-hospital patient care. | 0 | Pulling data from pre-hospital chart, work with mentor to develop specific question(s)/metric(s) of interest to student, design analysis plan in conjunction with mentor/biostatisics personnel, write/submit to national conference or journal (helicopter emergency medical services (HEMS), emergency medicine, quality, or critical care depending on interest/project goal chosen). Option for involvement in development of QI initiative if interested. | None required, will mentor. Engaged and willing to learn/work hard towards completion of meaningful research. | Under Review, expect approval early 2024 | No | Yes | Yes | Not currently available to mentor other students | No | Yes | Phoebe Natzke pnatzke@medicine.wisc.edu, Andrea Gilmore Bykovskyi algilmore@medicine.wisc.edu | Brittney Bernardoni, bernardoni@medicine.wisc.edu -- Co-Mentor: Craig Tschautscher, MD | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufzDfRXlTT60cgqZMGZ_Eq_-f-K7GtLXEMfxfaQU9DrNFUFCDT0_hGC1vQ0L0z2vU4 | |||||||
| 12/05/2023 | tschautsch@medicine.wisc.edu | Craig | Tschautscher | M.D., M.S. | Assistant Professor of Emergency Medicine | 6.126.167.772 | Emergency Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Influence of Critical Care Transport Vasopressor Management on Intensive Care Unit Care: Study will evaluate patients on vasopressors transported by UW Med Flight over a 2-year period. Primary objective is to determine if the vasopressor agents and dose selected by critical care transport teams were continued out through the first 24 hours of the Intensive Care Unit (ICU) stay, with secondary objectives to identify the occurrence hypotensive events inflight comparing high dose pressors vs dual agent therapy, to determine if the vasopressor agents and dose selected by outside facilities influence agent selection by critical care transport teams, and determine which patient factors influence a patient being on dual pressor therapy in transport. ____________________________________________________________________________ Role - Data abstraction, data collection.; IRB Status - Under review; Skills - Data entry, basic computer skills | Prehospital Medicine | Brittney Bernardoni M.D. | bernardoni@medicine.wisc.edu | Emergency Medicine | Prehospital Medicine | Influence of Critical Care Transport Vasopressor Management on Intensive Care Unit Care | Study will evaluate patients on vasopressors transported by UW Med Flight over a 2-year period. Primary objective is to determine if the vasopressor agents and dose selected by critical care transport teams were continued out through the first 24 hours of the Intensive Care Unit (ICU) stay, with secondary objectives to identify the occurrence hypotensive events inflight comparing high dose pressors vs dual agent therapy, to determine if the vasopressor agents and dose selected by outside facilities influence agent selection by critical care transport teams, and determine which patient factors influence a patient being on dual pressor therapy in transport. | 0 | Data abstraction, data collection. | Data entry, basic computer skills | Under review | No | Yes | Yes | Not currently available to mentor other students | No | No | Phoebe Natzke, pnatzke@medicine.wisc.edu | Craig Tschautscher, tschautsch@medicine.wisc.edu -- Co-Mentor: Brittney Bernardoni M.D. bernardoni@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudB0s76-s9wVO7SpMjnkAzM-1GoQtMH-f8369GFRp-y44d7uY-eP6V0hi296LwTPG4 | ||||
| 12/06/2023 | dchen@uwhealth.org | Derrick | Chen | MD | Clinical Microbiology Projects | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | Research Projects in Clinical Microbiology (Multiple): Please contact Dr. Chen if you are interested in doing a research project in clinical microbiology. There are multiple projects available on a variety of topics, and he can discuss them with you to see if any are of interest. Also, if there is something you're particularly interested in, a custom project can be created. Prior research experience is not needed, and Dr. Chen will guide the trainee through all the steps of research, from project design to publication. Most projects will involve data collection and chart review, so knowledge of and access to Excel and Epic/Hyperlink is generally required. Projects usually have a high chance of being accepted for presentation at a national conference (usually ASM Microbe and/or ID Week). Manuscript potential depends on the project and the data that is collected. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic Chart Review | Research Projects in Clinical Microbiology (Multiple) | Please contact Dr. Chen if you are interested in doing a research project in clinical microbiology. There are multiple projects available on a variety of topics, and he can discuss them with you to see if any are of interest. Also, if there is something you're particularly interested in, a custom project can be created. Prior research experience is not needed, and Dr. Chen will guide the trainee through all the steps of research, from project design to publication. Most projects will involve data collection and chart review, so knowledge of and access to Excel and Epic/Hyperlink is generally required. Projects usually have a high chance of being accepted for presentation at a national conference (usually ASM Microbe and/or ID Week). Manuscript potential depends on the project and the data that is collected. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic Chart Review | N/A | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students | No | No | N/A | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueX9Zgdi8GY9nD5EHz5x0ATV9U21ymjY93YoSJApoDB0k0_Vd-CLuZ-CFVj_WPuCVg | |||||||||
| 12/07/2023 | achiu4@wisc.edu | Alexander | Chiu | MD MPH | Assistant Professor | 7.734.807.542 | Surgery | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Developing Interventions to Improve Surgical Disparities: I am working to research, design, and implement interventions to improve disparities in access to surgery, with a focus on parathyroidectomy. There are many portions to this project, and the student may choose which aspect they are most interested in. The two projects that would be most approachable for a summer of work include a more quantitative analysis of surgical referral patterns and where the disparity lays. Namely, are there certain clinics/providers that are less likely to refer minority patients and identifying targetable barriers. A qualitative piece will be discussing with patients and providers about barriers and facilitators to equitable care. ____________________________________________________________________________ Role - Research Assistant; IRB Status - Complete; Skills - None required, and happy to teach methods as part of the summer | Endocrine Surgery | Developing Interventions to Improve Surgical Disparities | I am working to research, design, and implement interventions to improve disparities in access to surgery, with a focus on parathyroidectomy. There are many portions to this project, and the student may choose which aspect they are most interested in. The two projects that would be most approachable for a summer of work include a more quantitative analysis of surgical referral patterns and where the disparity lays. Namely, are there certain clinics/providers that are less likely to refer minority patients and identifying targetable barriers. A qualitative piece will be discussing with patients and providers about barriers and facilitators to equitable care. | 0 | Research Assistant | Moderate | None required, and happy to teach methods as part of the summer | Complete | No | No (plan to use Dean's Office Funds) | Yes | MPH students | No | Yes | N/A | Alexander Chiu, achiu4@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnud5-UTCUWkVaChkQIKvGcPmvQngHnHMMyY77bghcAR2hdxcyC9muFlxbMsufd-WPlc | |||||||
| 12/07/2023 | abirbrair@dermatology.wisc.edu | Alexander | Birbrair | PhD | Assistant Professor | Dermatology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Exploring molecular mechanisms in the control of cancer by the nervous system: We are interested in studying mechanisms that lead to cell behavior changes during cancer progression. Understanding how these mechanisms are affected in cancer will help develop targets for novel therapies. For this, we take advantage of state-of-the-art technologies, including microscopy, in vivo lineage-tracing methods, FACS-sorting, and sophisticated Cre/loxP techniques in combination with cancer mouse models. Thus, our ultimate goal is to identify novel potential cellular and molecular targets for cancer therapy. https://dermatology.wisc.edu/research/laboratory-research/birbrair-lab/ ____________________________________________________________________________ Role - The student will be following an experienced scientist in the lab. The student will need to take notes of all the experiments that he/she will be learning, participate in the lab meetings every Thursday, and after learning how, help to perform small experiments.; IRB Status - N/A; Skills - N/A – will learn in lab | Debpali Sur | dsur@dermatology.wisc.edu | Dermatology | Exploring molecular mechanisms in the control of cancer by the nervous system | We are interested in studying mechanisms that lead to cell behavior changes during cancer progression. Understanding how these mechanisms are affected in cancer will help develop targets for novel therapies. For this, we take advantage of state-of-the-art technologies, including microscopy, in vivo lineage-tracing methods, FACS-sorting, and sophisticated Cre/loxP techniques in combination with cancer mouse models. Thus, our ultimate goal is to identify novel potential cellular and molecular targets for cancer therapy. https://dermatology.wisc.edu/research/laboratory-research/birbrair-lab/ | 0 | The student will be following an experienced scientist in the lab. The student will need to take notes of all the experiments that he/she will be learning, participate in the lab meetings every Thursday, and after learning how, help to perform small experiments. | N/A – will learn in lab | N/A | Yes | Yes | Yes | Genetic Counseling students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | No | Mary Gannon, mgannon@dermatology.wisc.edu | Alexander Birbrair, abirbrair@dermatology.wisc.edu -- Co-Mentor: Debpali Sur dsur@dermatology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuecfs5shipTT76W85sHByxWk9wbpRluk-bmXL99QlhizmVVYLasUK7-zeCH1it2o1A | |||||||
| 12/07/2023 | mspulia@medicine.wisc.edu | Michael | Pulia | MD PhD | Associate Professor | Emergency Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Examining Novel Risk Factors for Pneumonia Development in Older Adults Presenting to the Emergency Department : Our previous work has identified a high prevalence of dysphagia, swallowing dysfunction, among older adults presenting to the ED with pneumonia. However, the prevalence of dysphagia among older adults presenting to the ED with other types of acute illness is unknown. Therefore, the primary objective of this study is to characterize swallow function in a cohort of older adults with a broad variety of both respiratory and non-respiratory acute medical conditions. We will prospectively recruit medically stable patients, age ≥65 years, presenting to the UW ED. Participants will complete a bedside water swallow test, respiratory strength testing, saliva collection, oral swabs and structured surveys to evaluate frailty, nutrition, oral health, and swallowing function. Participants will also have the option to complete a follow-up visit for instrumental swallow examination (e.g. VFES). Data from this project will be used to estimate the prevalence of dysphagia in a broad cohort of older adults in the ED and evaluate its role as a pneumonia risk factor in this vulnerable population. We will also evaluate the opportunity to evaluate the contribution of comorbidities, including frailty and malnutrition, as it relates to the presence and severity of dysphagia in this high-risk population. https://emed.wisc.edu/research/emergency-care-infectious-diseases/ ____________________________________________________________________________ Role - Assist with recruitment of patients in the ED, structured abstraction of data from the electronic health record, contribute to data analysis, manuscript writing, and poster presentation.; IRB Status - Pending; Skills - Strong preference for research experience, including data analysis and coding | Examining Novel Risk Factors for Pneumonia Development in Older Adults Presenting to the Emergency Department | Our previous work has identified a high prevalence of dysphagia, swallowing dysfunction, among older adults presenting to the ED with pneumonia. However, the prevalence of dysphagia among older adults presenting to the ED with other types of acute illness is unknown. Therefore, the primary objective of this study is to characterize swallow function in a cohort of older adults with a broad variety of both respiratory and non-respiratory acute medical conditions. We will prospectively recruit medically stable patients, age ≥65 years, presenting to the UW ED. Participants will complete a bedside water swallow test, respiratory strength testing, saliva collection, oral swabs and structured surveys to evaluate frailty, nutrition, oral health, and swallowing function. Participants will also have the option to complete a follow-up visit for instrumental swallow examination (e.g. VFES). Data from this project will be used to estimate the prevalence of dysphagia in a broad cohort of older adults in the ED and evaluate its role as a pneumonia risk factor in this vulnerable population. We will also evaluate the opportunity to evaluate the contribution of comorbidities, including frailty and malnutrition, as it relates to the presence and severity of dysphagia in this high-risk population. https://emed.wisc.edu/research/emergency-care-infectious-diseases/ | 0 | Assist with recruitment of patients in the ED, structured abstraction of data from the electronic health record, contribute to data analysis, manuscript writing, and poster presentation. | High | Strong preference for research experience, including data analysis and coding | Pending | Yes | Yes | Yes | MPH students, PhD students | No | No | Becky Schwei | Michael Pulia, mspulia@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuew6a06DTH2w86XbD64rAvx4nQsADmtvLlQFjXkZ7BYLSs1H3-xJxzp07yq3dqmgXM | |||||||||
| 12/07/2023 | rcoller@pediatrics.wisc.edu | Ryan | Coller | MD, MPH | Associate Professor of Pediatrics, Chief, Division of Hospital Medicine and Complex Care | 608 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Children with Serious and Complex Illness - Improving Hospital and Home Care for Children and their Families : Our student would be engaged in research across one or more of five existing projects, based on interest and experience: 1. Caregiver Stories: Medical Education Curricular Innovation in which caregiver stories are recorded and used in our elective to increase awareness of the family perspective/experience of caring for children with medical complexity; 2. Wisconsin Policy for In-home Care: policy review and intervention development for WI policy related to professional in-home care for children with medical complexity; 3. Meds@HOME: a randomized clinical trial of an app to improve medication safety for children taking high-risk medications; 4. Family CIRLCE: a prospective longitudinal cohort study of children with chronic diseases across 8 US sites; 5. iSHARE or qRounds: clinical trials focused on improving safety of inpatient care. ____________________________________________________________________________ Role - Develop project aim. Literature review, Participant recruitment, Data entry, potential for analysis, participate in team meetings. Leadership at the level and comfort of student. ; IRB Status - Approved; Skills - Comfort with office suite (excel, word), ability to carry out literature review in collaboration with faculty and librarians, enthusiasm for observing and potentially coding interviews with caregivers | Hospital Medicine and Complex Care | Heidi Kloster, MD, Mary Ehlenbach, MD, Michelle Kelly, MD, PhD | hkloster@wisc.edu; mehlenbach@pediatrics.wisc.edu; michelle.kelly@wisc.edu | Pediatrics | Hospital Medicine and Complex Care | Children with Serious and Complex Illness - Improving Hospital and Home Care for Children and their Families | Our student would be engaged in research across one or more of five existing projects, based on interest and experience: 1. Caregiver Stories: Medical Education Curricular Innovation in which caregiver stories are recorded and used in our elective to increase awareness of the family perspective/experience of caring for children with medical complexity; 2. Wisconsin Policy for In-home Care: policy review and intervention development for WI policy related to professional in-home care for children with medical complexity; 3. Meds@HOME: a randomized clinical trial of an app to improve medication safety for children taking high-risk medications; 4. Family CIRLCE: a prospective longitudinal cohort study of children with chronic diseases across 8 US sites; 5. iSHARE or qRounds: clinical trials focused on improving safety of inpatient care. | 1 | Develop project aim. Literature review, Participant recruitment, Data entry, potential for analysis, participate in team meetings. Leadership at the level and comfort of student. | Self-directed day-to-day, but regular oversight and access to mentors and project staff. | Comfort with office suite (excel, word), ability to carry out literature review in collaboration with faculty and librarians, enthusiasm for observing and potentially coding interviews with caregivers | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Yes | N/A | Ryan Coller, rcoller@pediatrics.wisc.edu -- Co-Mentor: Heidi Kloster, MD, Mary Ehlenbach, MD, Michelle Kelly, MD, PhD hkloster@wisc.edu; mehlenbach@pediatrics.wisc.edu; michelle.kelly@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufxu_rTRDEn7xNAmyjqfUxJGYdiPJPxTKNDo16tBgCPKsyOacRBWZ4S4QNI7Fg28po | |||
| 12/07/2023 | sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Associate Professor | Medicine | Shorter term projects, Research Electives for credit | The Association of 25-Hydroxyvitamin D Levels with BK viremia and nephropathy in Kidney Transplant Recipients: post-transplant vit D levels have been associated with various detrimental outcomes including risk for CMV viremia, recurrence of glomerulonephritis after transplant. It is not clear if there is any association between serum vit D levels within first six months post transplant and BK viremia and BK nephropathy. We will replicate almost similar study as of vit D and CMV infection published before PMID: 30801528 DOI: 10.1097/TP.0000000000002672 ____________________________________________________________________________ Role - Will lead the project and will be the first author of the project. Will work closely with myself and Dr. Astor, along with other team members. ; IRB Status - Will be approved soon, will go through Transplant Umbrella IRB ; Skills - None, just need energy and enthusiasm. | Nephrology-Transplant | Dr. Brad Astor | bcastor@medicine.wisc.edu | The Association of 25-Hydroxyvitamin D Levels with BK viremia and nephropathy in Kidney Transplant Recipients | post-transplant vit D levels have been associated with various detrimental outcomes including risk for CMV viremia, recurrence of glomerulonephritis after transplant. It is not clear if there is any association between serum vit D levels within first six months post transplant and BK viremia and BK nephropathy. We will replicate almost similar study as of vit D and CMV infection published before PMID: 30801528 DOI: 10.1097/TP.0000000000002672 | 0 | Will lead the project and will be the first author of the project. Will work closely with myself and Dr. Astor, along with other team members. | Student will be independent with guidance | None, just need energy and enthusiasm. | Will be approved soon, will go through Transplant Umbrella IRB | No | or any other funds similar to last year | Yes | Not currently available to mentor other students | No | No | N/A | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: Dr. Brad Astor bcastor@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufQqWdkWRZI-rsS2XAyLUzcD0WMW-jLX6vpmtOZ-LFXid3btdNY9jdU7eLk9BLCrvg | ||||||
| 12/07/2023 | sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Associate Professor | Medicine | Shorter term projects, Research Electives for credit | Risk factors and outcomes of delayed graft function among donation after circulatory death and brain death donor in kidney transplant recipients: Kidney delayed graft function (DGF) is a common complications after kidney transplant. circulatory death donor (DCD) are at increased risk for DGF. It is not known what the risk factors are and how it differs between brain death donor (DBD) and DCD for risk factors and outcomes. Check- doi: 10.1097/TXD.0000000000001433 PMID: 36700066 ____________________________________________________________________________ Role - Student will lead the project and will be the first author, will work closely with myself and Dr. Astor ; IRB Status - Will be approved soon, will go through Transplant Umbrella IRB ; Skills - None, just need energy and enthusiasm. | Nephrology-Transplant | Dr. Brad Astor | bcastor@medicine.wisc.edu | Risk factors and outcomes of delayed graft function among donation after circulatory death and brain death donor in kidney transplant recipients | Kidney delayed graft function (DGF) is a common complications after kidney transplant. circulatory death donor (DCD) are at increased risk for DGF. It is not known what the risk factors are and how it differs between brain death donor (DBD) and DCD for risk factors and outcomes. Check- doi: 10.1097/TXD.0000000000001433 PMID: 36700066 | 0 | Student will lead the project and will be the first author, will work closely with myself and Dr. Astor | Student will be independent with guidance | None, just need energy and enthusiasm. | Will be approved soon, will go through Transplant Umbrella IRB | No | or any other funds similar to last year | Yes | Not currently available to mentor other students | No | No | N/A | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: Dr. Brad Astor bcastor@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf9LcZDpUEcrIlziunArgP4rKwuVFk3cR5UJ3pHgWJsoRBKpPS6-we6uBxNBlDISrY | ||||||
| 12/07/2023 | ahurst@medicine.wisc.edu | Allie | Hurst | MD, MS | Assistant Professor, Pediatric Emergency Medicine | Emergency Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Child Sex Trafficking Screening Trends: The Changing Environment of Online Exploitation and Screening Responses: Child sex trafficking is a pervasive issue throughout the world, and screening for such in medical facilities is standard of care. In the Pediatric Emergency Department at the University of Wisconsin-Madison, a screening tool has been employed since March 2022. As the invent of social media and the COVID-19 pandemic has increased the likelihood of online exploitation, the risk factors for exploitation and patient responses to the screening tool have likely changed. The focus of this project will be to compare survey responses from our dataset of screened at-risk adolescents to screening responses prior to the COVID-19 pandemic. This project will provide experience and education in the area of child sex trafficking, data processing and review, clinical science manuscript writing, and presenting analysis at the local and possibly national level. ____________________________________________________________________________ Role - Contribute to data analysis, manuscript writing, poster creation and presentation, HealthLink access; IRB Status - Not submitted; Skills - Basic computer skills, HealthLink awareness/access, powerpoint/word savvy | Pediatrics | Child Sex Trafficking Screening Trends: The Changing Environment of Online Exploitation and Screening Responses | Child sex trafficking is a pervasive issue throughout the world, and screening for such in medical facilities is standard of care. In the Pediatric Emergency Department at the University of Wisconsin-Madison, a screening tool has been employed since March 2022. As the invent of social media and the COVID-19 pandemic has increased the likelihood of online exploitation, the risk factors for exploitation and patient responses to the screening tool have likely changed. The focus of this project will be to compare survey responses from our dataset of screened at-risk adolescents to screening responses prior to the COVID-19 pandemic. This project will provide experience and education in the area of child sex trafficking, data processing and review, clinical science manuscript writing, and presenting analysis at the local and possibly national level. | 0 | Contribute to data analysis, manuscript writing, poster creation and presentation, HealthLink access | Basic computer skills, HealthLink awareness/access, powerpoint/word savvy | Not submitted | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | n/a | Allie Hurst, ahurst@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucH9lgdG-51YWxy7MKqGSK1bPc3r6Cji_zwISMFF2stElNjsaMyY5S3YYE0PySVrbc | |||||||||
| 12/07/2023 | stephen.meyn@wisc.edu | Stephen | Meyn | MD PhD | Director, Center for Human Genomics and Precision Medicine | 608 | Pediatrics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | BadgerSeq: A new paradigm for the genomic diagnosis of critically ill newborns: Background: ~2,000 infants in Wisconsin are born each year with a rare genetic disorder or birth defect, comprising 20-30% of patients in level IV NICUs. These infants have high acuity, prolonged hospital stays, and a lifetime of health challenges. Molecular diagnosis is key to caring for these infants and speed is critical, as rapid diagnosis in the NICU leads to more clinically valuable results and higher cost savings. As a result, rapid genome sequencing is becoming the genetic test of choice in the NICU. Yet, current practice has major weaknesses: a) Inequity - Rapid genome sequencing is rarely ordered in community and regional hospitals due to a lack of genetic services while insurance restrictions limit its use at American Family Children’s Hospital (AFCH) and Children’s of Wisconsin (CHW); b) Reach - current technology cannot detect many clinically important genomic variants; and c) Speed – rapid sequencing results typically come back in 10-20 days, after critical clinical decisions have been made. To help overcome these weaknesses, we are developing BadgerSeq, a novel genome sequencing paradigm that a) utilizes machine learning algorithms to enable the daily evaluation of all NICU patients in order to identify infants who might benefit from genome sequencing; and b) replaces 2nd generation short read sequencing with novel 3rd generation long-read sequencing. The goal is to deliver better genomic and epigenomic analyses in less time: 3-4 days after clinical presentation. ____________________________________________________________________________ Role - We are looking for two students. One student to assist in developing the medical informatics workflow (automated extraction of clinical information - HPO terms - from the EMR, which is then fed into an existing algorithm, the Mendelian Phenotype Search engine. Another student to assist in developing the ultra rapid sequencing pipeline, which is based on Nanopore long read sequencing.; IRB Status - N/A; Skills - A medical informatics or machine learning background would be helpful for the first position. Experience with next gen or 3rd gen sequencing would be helpful for the second position (this includes bioinformatics and/or wet bench experience.) | Genetics and Metabolism | BadgerSeq: A new paradigm for the genomic diagnosis of critically ill newborns | Background: ~2,000 infants in Wisconsin are born each year with a rare genetic disorder or birth defect, comprising 20-30% of patients in level IV NICUs. These infants have high acuity, prolonged hospital stays, and a lifetime of health challenges. Molecular diagnosis is key to caring for these infants and speed is critical, as rapid diagnosis in the NICU leads to more clinically valuable results and higher cost savings. As a result, rapid genome sequencing is becoming the genetic test of choice in the NICU. Yet, current practice has major weaknesses: a) Inequity - Rapid genome sequencing is rarely ordered in community and regional hospitals due to a lack of genetic services while insurance restrictions limit its use at American Family Children’s Hospital (AFCH) and Children’s of Wisconsin (CHW); b) Reach - current technology cannot detect many clinically important genomic variants; and c) Speed – rapid sequencing results typically come back in 10-20 days, after critical clinical decisions have been made. To help overcome these weaknesses, we are developing BadgerSeq, a novel genome sequencing paradigm that a) utilizes machine learning algorithms to enable the daily evaluation of all NICU patients in order to identify infants who might benefit from genome sequencing; and b) replaces 2nd generation short read sequencing with novel 3rd generation long-read sequencing. The goal is to deliver better genomic and epigenomic analyses in less time: 3-4 days after clinical presentation. | 2 | We are looking for two students. One student to assist in developing the medical informatics workflow (automated extraction of clinical information - HPO terms - from the EMR, which is then fed into an existing algorithm, the Mendelian Phenotype Search engine. Another student to assist in developing the ultra rapid sequencing pipeline, which is based on Nanopore long read sequencing. | moderately independent | A medical informatics or machine learning background would be helpful for the first position. Experience with next gen or 3rd gen sequencing would be helpful for the second position (this includes bioinformatics and/or wet bench experience.) | N/A | This project is currently funded by internal funds | Yes | Yes | Genetic Counseling students, PhD students, UW undergraduates interested in research | Yes | Unsure / Depends | Jackie McHugh (jamchugh@wisc.edu) | Stephen Meyn, stephen.meyn@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufWf1yC4ZbG_exVCBmd44cclU3oRlbHzVCZu0fI4D0M0GpqueYPEjO_2cwwRKKu-04 | |||||||
| 12/07/2023 | calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Establishing the Current State of Oncology Survivorship Care at University of Wisconsin Carbone Cancer Center: Survivorship care after the completion of disease-directed therapy for oncologic diagnoses is a growing field. The frequency, intensity and type of care provided varies based on exact diagnosis, treating team, oncologist preference and patient availability. The University of Wisconsin Carbone Cancer Center (UWCCC) does not have a unified approach to survivorship, rather each disease group within UWCCC determines its own plan for how to care for patients after they have completed therapy. To our knowledge, no audit of existing survivorship programs at UWCCC has been previously completed. The goal of this project is to determine the extent and nature of survivorship care within each Disease-Oriented Team (DOT) of UWCCC. We hope to compile that information and share it back with all members of the Cancer Center in order to establish a baseline, determine priorities for improving care and identify opportunities for collaboration. ____________________________________________________________________________ Role - As this is a new project, students will help define their role based on their interests and skillset. We envision working to identify the survivorship care champion within each DOT, deploying a survey to those champions to gather data about survivorship care, and compiling those data into both a presentation and poster form. We also hope to identify key action items moving forward to help improve overall survivorship care at UWCCC. Any students involved in this project are welcome to participate in any or all of the steps of this project.; IRB Status - student will help apply for IRB exemption; Skills - excellent communication skills, survey design, data analysis, public speaking (possibly) | Pediatric Hematology/Oncology | Priyanka Pophali, MD, Assistant Professor of Medicine | pophali@wisc.edu | Medicine | Medical Oncology | Establishing the Current State of Oncology Survivorship Care at University of Wisconsin Carbone Cancer Center | Survivorship care after the completion of disease-directed therapy for oncologic diagnoses is a growing field. The frequency, intensity and type of care provided varies based on exact diagnosis, treating team, oncologist preference and patient availability. The University of Wisconsin Carbone Cancer Center (UWCCC) does not have a unified approach to survivorship, rather each disease group within UWCCC determines its own plan for how to care for patients after they have completed therapy. To our knowledge, no audit of existing survivorship programs at UWCCC has been previously completed. The goal of this project is to determine the extent and nature of survivorship care within each Disease-Oriented Team (DOT) of UWCCC. We hope to compile that information and share it back with all members of the Cancer Center in order to establish a baseline, determine priorities for improving care and identify opportunities for collaboration. | 0 | As this is a new project, students will help define their role based on their interests and skillset. We envision working to identify the survivorship care champion within each DOT, deploying a survey to those champions to gather data about survivorship care, and compiling those data into both a presentation and poster form. We also hope to identify key action items moving forward to help improve overall survivorship care at UWCCC. Any students involved in this project are welcome to participate in any or all of the steps of this project. | need to be self-directed and know when to reach out for help | excellent communication skills, survey design, data analysis, public speaking (possibly) | student will help apply for IRB exemption | No | Yes | Yes | MPH students | No | Yes | N/a | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: Priyanka Pophali, MD, Assistant Professor of Medicine pophali@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueANKYfxZw1kuNSm9egfc0fTqgW4qII9uGNs4cgCs12rCUzRuq12acRl5OnhMGrdos | ||||
| 12/08/2023 | lhanks@wisc.edu | Laura | Hanks | MD | Clinical Assistant Professor | 434 | Obstetrics & Gynecology | Shorter term projects | Comparing complication rates of hysterectomies in transgender and gender diverse individuals with cis-gender females: We will be evaluating complications rates after hysterectomies in transgender and gender diverse (TGD) individuals with cis-gender females. Primary outcome will be vaginal cuff dehiscence. Secondary outcomes will be vaginal bleeding, ER visits, infection and hospital readmission. ____________________________________________________________________________ Role - Data collection and review. Compose a presentation and write a manuscript. Recommend taking manuscript writing course during this time, directions for this will be given. ; IRB Status - In discussion as of 12/8/23; Skills - Ability to use Epic (bother Meriter and UW). Entering data into RedCap. Ability to create powerpoint and write a manuscript with assistance from mentor. | ASOG | Comparing complication rates of hysterectomies in transgender and gender diverse individuals with cis-gender females | We will be evaluating complications rates after hysterectomies in transgender and gender diverse (TGD) individuals with cis-gender females. Primary outcome will be vaginal cuff dehiscence. Secondary outcomes will be vaginal bleeding, ER visits, infection and hospital readmission. | 0 | Data collection and review. Compose a presentation and write a manuscript. Recommend taking manuscript writing course during this time, directions for this will be given. | Mostly independent with help and assistance from mentor as needed. | Ability to use Epic (bother Meriter and UW). Entering data into RedCap. Ability to create powerpoint and write a manuscript with assistance from mentor. | In discussion as of 12/8/23 | No | Will submit for Department to assist with this | Yes | UW undergraduates interested in research | No | Unsure / Depends | Sharon Blohowiak (IRB specialist) | Laura Hanks, lhanks@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudL6vBOcLS419v_DeVXW41Z1y50KUkMun64U5dLOlKbHPOdc1hUYq_6Bq2N-C4MSME | |||||||
| selkie@wisc.edu | Ellen | Selkie | MD, MPH | Assistant Professor | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Adolescent Wellbeing and Social Media Experiences: The Learning More From Adolescents Online (LMFAO) Research Team (lmfaoteam.org) seeks to identify ways to promote well-being for adolescents and young adults when using technology and digital media. The current project is part of the The Brain, Behavior, and wellBeing (B3) study (b3study.org), in which adolescent participants share their social media content and complete surveys and interviews among other study tasks. The goal of this work is to determine how adolescents present their own social media content ("self-generated content") and experience social media content from influencers, celebrities, family, friends, and more ("other-generated content"), and the implications of this content for adolescent socioemotional wellbeing (e.g., stress, loneliness, self-esteem). Students working with the LMFAO Team through the Shapiro program will gain: 1) experience in literature reviews, interview skills and qualitative data collection and analysis; 2) opportunities for abstract submission and publication; 3) work with a dynamic interdisciplinary team with psychology and public health backgrounds; research and career mentoring from Dr. Selkie, an Adolescent Medicine physician ____________________________________________________________________________ Role - Student activities for the project include performing literature reviews, conducting interviews with adolescents, and coding participants’ social media content in our lab at 2870 University Ave. The coding team meets weekly to refine our qualitative codebook, which categorizes the content that participants generate themselves. Semi-structured virtual interviews explore the accounts participants follow on social media and explore their experiences of that content. Interviews may be conducted in the evenings or on weekends. We have both existing and forthcoming data that can be integrated into individual Shapiro projects.; IRB Status - Approved; Skills - Microsoft Office proficiency | General Pediatrics and Adolescent Medicine | Adolescent Wellbeing and Social Media Experiences | The Learning More From Adolescents Online (LMFAO) Research Team (lmfaoteam.org) seeks to identify ways to promote well-being for adolescents and young adults when using technology and digital media. The current project is part of the The Brain, Behavior, and wellBeing (B3) study (b3study.org), in which adolescent participants share their social media content and complete surveys and interviews among other study tasks. The goal of this work is to determine how adolescents present their own social media content ("self-generated content") and experience social media content from influencers, celebrities, family, friends, and more ("other-generated content"), and the implications of this content for adolescent socioemotional wellbeing (e.g., stress, loneliness, self-esteem). Students working with the LMFAO Team through the Shapiro program will gain: 1) experience in literature reviews, interview skills and qualitative data collection and analysis; 2) opportunities for abstract submission and publication; 3) work with a dynamic interdisciplinary team with psychology and public health backgrounds; research and career mentoring from Dr. Selkie, an Adolescent Medicine physician | 2 | Student activities for the project include performing literature reviews, conducting interviews with adolescents, and coding participants’ social media content in our lab at 2870 University Ave. The coding team meets weekly to refine our qualitative codebook, which categorizes the content that participants generate themselves. Semi-structured virtual interviews explore the accounts participants follow on social media and explore their experiences of that content. Interviews may be conducted in the evenings or on weekends. We have both existing and forthcoming data that can be integrated into individual Shapiro projects. | Microsoft Office proficiency | Approved | Yes | Yes | Yes | DPT students, MPH students, PhD students, UW undergraduates interested in research | No | Yes | Christine Richards, Abigail Suleman, Lydia Bliss | Ellen Selkie, selkie@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueqG2W7HetTb9IJ7PhUfhHIzYxElom_j5dYQXeAAsQoX4BERJmuUGh2oZTNSoRnBBE | ||||||||||
| 12/10/2023 | bbhagavath@wisc.edu | Bala | Bhagavath | MD | Director, Division of Reproductive Endocrinology and Infertility | Obstetrics & Gynecology | Research Electives for credit | Pelvic Infection after Egg Retrieval in Patients with Endometriosis: Pelvic infection during egg retrieval is altogether uncommon. However, when it happens, it is very serious. There is limited study and evidence surrounding the appropriate regimen. Although endometriosis is assumed to be a risk factor for infection during egg retrieval, there is limited data. This research will set out to compare rates of infection in those who received versus did not receive prophylactic antibiotic treatment and also investigate if those with endometriosis undergoing egg retrieval have a higher risk of infection or not. This will be done as a retrospective cohort study. ____________________________________________________________________________ Role - Chart review, RedCap data entry, manuscript writing, and, if interested, statistics ; IRB Status - Exempt ; Skills - None | Reproductive Endocrinology and Infertility | Christina Dudley, MD, Ob-Gyn Resident | cdudley@uwhealth.org | Obstetrics & Gynecology | Pelvic Infection after Egg Retrieval in Patients with Endometriosis | Pelvic infection during egg retrieval is altogether uncommon. However, when it happens, it is very serious. There is limited study and evidence surrounding the appropriate regimen. Although endometriosis is assumed to be a risk factor for infection during egg retrieval, there is limited data. This research will set out to compare rates of infection in those who received versus did not receive prophylactic antibiotic treatment and also investigate if those with endometriosis undergoing egg retrieval have a higher risk of infection or not. This will be done as a retrospective cohort study. | 0 | Chart review, RedCap data entry, manuscript writing, and, if interested, statistics | None | Exempt | OB-Gyn Resident Research Program | Yes | Yes | Not currently available to mentor other students | No | No | Amy Godecker, godecker@wisc.edu | Bala Bhagavath, bbhagavath@wisc.edu -- Co-Mentor: Christina Dudley, MD, Ob-Gyn Resident cdudley@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufUfyU_SF-1SuVpHwdsjDihmQKdrxTAYJClD0Fe8_LDXouMH3XmmC07yNGTtyI11Xo | ||||||
| setraynor@wisc.edu | Sarah | Traynor | PhD | Teaching Faculty II | 6.082.627.993 | Academic Affairs | Not currently interested or available for Non-Shapiro research mentoring of medical students | Body donor demographics research project: The goal of the project is to better understand the population of people who donate their body to the Body Donor Program at the UWSMPH for anatomical education. Research directions will depend on student interest but will include collecting demographic and programmatic data from donor death certificate worksheets and other relevant donor registration forms to better inform our program, our students, and the broader community. Initial demographic data from body donors who passed between 2016 and 2021 was collected for a pilot study and results were presented at three professional conferences. Similarly, this Shapiro research project will yield results that can be readily translated into a research presentation and/or manuscript. ____________________________________________________________________________ Role - Student will collect data from donor death certificate worksheets and other relevant donor registration forms to inform their research question/s. Student will analyze their data and present their results. Statistical help will be provided as needed.; IRB Status - N/A; Skills - Student needs to be self-motivated, curious, and able to work independently. Basic skills with Microsoft Excel are required. | Anatomy Teaching Group | Meghan Cotter PhD | mmcotter@wisc.edu | Academic Affairs | Body donor demographics research project | The goal of the project is to better understand the population of people who donate their body to the Body Donor Program at the UWSMPH for anatomical education. Research directions will depend on student interest but will include collecting demographic and programmatic data from donor death certificate worksheets and other relevant donor registration forms to better inform our program, our students, and the broader community. Initial demographic data from body donors who passed between 2016 and 2021 was collected for a pilot study and results were presented at three professional conferences. Similarly, this Shapiro research project will yield results that can be readily translated into a research presentation and/or manuscript. | 0 | Student will collect data from donor death certificate worksheets and other relevant donor registration forms to inform their research question/s. Student will analyze their data and present their results. Statistical help will be provided as needed. | Student is expected to independently collect data and work to address their research question/s using the data. Mentor guidance will be available throughout the process. | Student needs to be self-motivated, curious, and able to work independently. Basic skills with Microsoft Excel are required. | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Unsure / Depends | N/A | Sarah Traynor, setraynor@wisc.edu -- Co-Mentor: Meghan Cotter PhD mmcotter@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucsHbr8fUV_NgEQ_tylTw9IrJu1O6Gcf42_CYZ8XeAephcZGjp1qHydT2DbaytQ3s8 | |||||
| 12/12/2023 | wellik@wisc.edu | Deneen | Wellik | PhD | Professor | 608 | Cell and Regenerative Biology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Interrogating muscle hypertrophy with loss of Hox-expressing interstitial cell progenitors: This project will follow results published from the Wellik laboratory this year (Flynn, et al, Development, 2023) where we report the novel ability of a subset of muscle interstitial cells to provide new myonuclei broadly at homeostasis. Using the mouse genetic models already established in the lab, we will next measure the ability of this interstitial cell population to contribute to induced skeletal muscle hypertrophy (using both surgical and exercise mouse models in collaboration with the Hornberger laboratory). ____________________________________________________________________________ Role - The student will lead the experiments described above with mentorship from the PIs and mambers of the PIs' laboratories. Skills gained will include mouse genetics, fixation and preparation of skeletal muscle, immunoflourescence and image analyses, and an opportunity to learn the mouse models of skeletal muscle hypertrophy.; IRB Status - N/A (animal protocols approved); Skills - basic bench skills, but can train on techniques | Troy Hornberger | troy.hornberger@wisc.edu | Other | School of Vet Med, Comparative Biosciences | Interrogating muscle hypertrophy with loss of Hox-expressing interstitial cell progenitors | This project will follow results published from the Wellik laboratory this year (Flynn, et al, Development, 2023) where we report the novel ability of a subset of muscle interstitial cells to provide new myonuclei broadly at homeostasis. Using the mouse genetic models already established in the lab, we will next measure the ability of this interstitial cell population to contribute to induced skeletal muscle hypertrophy (using both surgical and exercise mouse models in collaboration with the Hornberger laboratory). | 1 | The student will lead the experiments described above with mentorship from the PIs and mambers of the PIs' laboratories. Skills gained will include mouse genetics, fixation and preparation of skeletal muscle, immunoflourescence and image analyses, and an opportunity to learn the mouse models of skeletal muscle hypertrophy. | moderate | basic bench skills, but can train on techniques | N/A (animal protocols approved) | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | No | N/A | Deneen Wellik, wellik@wisc.edu -- Co-Mentor: Troy Hornberger troy.hornberger@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueqCPOeLdRQdklz8H7tJa3QL5IqzUphKdddAJGfZCGPKrtBt3aNIjip8mbwzA84PE8 | ||||
| mramrat@medicine.wisc.edu | Mohun | Ramratnam | MD | Associate Professor | 4.438.041.406 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Targeting mitochondrial potassium channels to treat heart disease: Mitochondrial potassium channel activity are intricately linked to cardio-protection. However, targeting the mitochondrial potassium cycle to treat human heart disease is challenging due to the lack of clarity that surrounds the specific physiologic roles that proteins play in K+ cycling. Laboratories, including our own, have found evidence for a cardiac mitochondrial ROMK (renal outer medullary potassium) channel. However, its mitochondrial significance is unknown. We have found that inhibition of ROMK mediates cardiac ischemic injury and are currently working on its mechanism. ROMK is in the family of inward rectifying potassium channel and therefore the specific cofactor PIP2 is needed for proper channel activity. How PIP2 regulates mitochondria potassium handling or membrane potential is unclear. Therefore we seek to understand how PIP2 serves as a second messenger to mitochondria and how it regulates potassium channel activity and mitochondrial membrane potential. ____________________________________________________________________________ Role - The student will obtain guidance and supervision with the following tasks 1. Isolating mitochondria from mouse hearts 2. Running experiments with isolated mitochondria in a fluorometer ; IRB Status - N/A; Skills - none | Cardiovascular Medicine | N/A | N/A | Targeting mitochondrial potassium channels to treat heart disease | Mitochondrial potassium channel activity are intricately linked to cardio-protection. However, targeting the mitochondrial potassium cycle to treat human heart disease is challenging due to the lack of clarity that surrounds the specific physiologic roles that proteins play in K+ cycling. Laboratories, including our own, have found evidence for a cardiac mitochondrial ROMK (renal outer medullary potassium) channel. However, its mitochondrial significance is unknown. We have found that inhibition of ROMK mediates cardiac ischemic injury and are currently working on its mechanism. ROMK is in the family of inward rectifying potassium channel and therefore the specific cofactor PIP2 is needed for proper channel activity. How PIP2 regulates mitochondria potassium handling or membrane potential is unclear. Therefore we seek to understand how PIP2 serves as a second messenger to mitochondria and how it regulates potassium channel activity and mitochondrial membrane potential. | 1 | The student will obtain guidance and supervision with the following tasks 1. Isolating mitochondria from mouse hearts 2. Running experiments with isolated mitochondria in a fluorometer | minimal | none | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | No | N/A | Mohun Ramratnam, mramrat@medicine.wisc.edu -- Co-Mentor: N/A N/A | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufF3SK_nifR4FMQlU_s1sXCVB8i9poR6Fx1W5ifiQIzufo5qleA7G3kX3FUULC2pS0 | ||||||
| abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MBA, MPH, CPE, FASA | Medical Director, Pain Managamenet | 2.163.461.739 | Anesthesiology | Shorter term projects, Research Electives for credit | Posterior placement of intrathecal pumps: Intrathecal pumps have been historically placed in the abdomen. We started about 9 years ago to place them in the back which lowered operative time and complications. We want to collect data on outcomes of placement of pumps posteriorly ____________________________________________________________________________ Role - Data collection, writing; IRB Status - exemption available; Skills - commitment, good organizational skills, good writing skills | Pain | Posterior placement of intrathecal pumps | Intrathecal pumps have been historically placed in the abdomen. We started about 9 years ago to place them in the back which lowered operative time and complications. We want to collect data on outcomes of placement of pumps posteriorly | 0 | Data collection, writing | commitment, good organizational skills, good writing skills | exemption available | No | covered by the Department of Anesthesia | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | Yes | jasullivan@wisc.edu | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueRL5WQ5KT34TN01cKHg6sRKXXXcp07ANYPa0l17WnT2S7E_2eSjLraFmPoCvBVTMg | |||||||||
| abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MBA, MPH, CPE, FASA | Medical Director, Pain | Anesthesiology | Shorter term projects, Research Electives for credit | Radiofrequency ablation for thoracic spine and peripheral nerves: We perform cooled radiofrequency ablation for thoracic spine and peripheral nerves which are performed in few centers in the US. We would like to collect outcomes of those procedures ____________________________________________________________________________ Role - Data collection, writing; IRB Status - Exemption; Skills - commitment, good organizational skills, good writing skills | Radiofrequency ablation for thoracic spine and peripheral nerves | We perform cooled radiofrequency ablation for thoracic spine and peripheral nerves which are performed in few centers in the US. We would like to collect outcomes of those procedures | 0 | Data collection, writing | commitment, good organizational skills, good writing skills | Exemption | No | Covered by Department of Anesthesia | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | Yes | jasullivan@wisc.edu | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucWBPEvKP_EI7V_XXW5WNklgkzQuQWbMaHM6hPTOQldP9b-YmIzyyHjfqulXyvJUoc | |||||||||||
| jdkratz@medicine.wisc.edu | Jeremy | Kratz | MD | Assistant Professor | 608 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Impact of Precision Oncology in Learning Healthcare Model: The Cancer Moonshot has enabled significant resources in characterizing the molecular changes that make cancer unique to an individual. In response to these efforts, the Veteran’s Administration has launched the National Precision Oncology Program dedicated to characterize the breadth of molecular findings across the integrated VA network. No studies to date have characterized the unique molecular alterations in Veterans with Gastrointestinal oncology for which this data set serves integral to understanding unique targets and the role of environmental exposure in driving distinct pathologic alterations. This project includes understanding modern techniques in defining clinically actionable molecular targets across cancer types. We are looking for two students for dedicated projects tailored to personal interests across a diversity of cancer types. ____________________________________________________________________________ Role - Research Assistant; IRB Status - Approved; Skills - Team oriented, dedicated, skills with basic microsoft software | Oncology | Other | Center for Human Genomics and Precision Medicine | Impact of Precision Oncology in Learning Healthcare Model | The Cancer Moonshot has enabled significant resources in characterizing the molecular changes that make cancer unique to an individual. In response to these efforts, the Veteran’s Administration has launched the National Precision Oncology Program dedicated to characterize the breadth of molecular findings across the integrated VA network. No studies to date have characterized the unique molecular alterations in Veterans with Gastrointestinal oncology for which this data set serves integral to understanding unique targets and the role of environmental exposure in driving distinct pathologic alterations. This project includes understanding modern techniques in defining clinically actionable molecular targets across cancer types. We are looking for two students for dedicated projects tailored to personal interests across a diversity of cancer types. | 2 | Research Assistant | Team oriented, dedicated, skills with basic microsoft software | Approved | Yes | Yes | Yes | PhD students, UW undergraduates interested in research | No | Yes | Austin Stram (astram@wisc.edu) | Jeremy Kratz, jdkratz@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudio3xZFKijXabf5jtVvpYy1_VZ1jXKZOutHT95Zwjc1cZDCUToRJ7HXX9y24ridJo | |||||||
| ssrinivasan3@wisc.edu | Shardha | Srinivasan | MBBS MD | Assoc. Prof of Pediatrics | 608 | Pediatrics | Shorter term projects | Prenatal Genetic Testing and outcomes in fetuses with Congenital Cardiac Malformations: Congenital Cardiac Defects are the most common form of congenital malformation. While many are minor about a third involve complex defects needing neonatal cardiac intervention. Overall surgical outcomes including mortality as well as morbidity is impacted by the presence of underlying chromosomal abnormalities. For example the underlying risk for poor neurodevelopmental outcomes may be modified by the impact of associated aneuploidy or genetic aberrations. These are important considerations impacting prognostication in prenatal counselling. There have been rapid advances in the area of genetic testing yet options are often limited in the prenatal period due to several reasons including need for invasive testing as well as limitations in insurance coverage and high out of pocket costs. In this study we propose a retrospective review of fetal diagnosis of congenital cardiac abnormality to 1. evaluate results of prenatal and postnatal genetic testing in this cohort 2. evaluate impact of genetic test results on fetal and neonatal outcomes. The findings of this study may direct future QI projects to drive change in prenatal genetic testing patterns and improved insurance coverage for more comprehensive genetic testing as well as help guide informed counselling for families. This project will need access to patient records both at UW/AFCH as well as Unity-Point Meriter Hospital. ____________________________________________________________________________ Role - Literature review, chart review, making a red cap database and analysis. Goal is to have an abstract and possibly a manuscript or this will lead to a QI project; IRB Status - NA; Skills - Familiarity with REDcap database creation, literature review | Pediatric Cardiology | Allie Kiley RN Fetal Cardiac Care Coordinator | AKiley@uwhealth.org | Pediatrics | Pediatric Cardiology | Prenatal Genetic Testing and outcomes in fetuses with Congenital Cardiac Malformations | Congenital Cardiac Defects are the most common form of congenital malformation. While many are minor about a third involve complex defects needing neonatal cardiac intervention. Overall surgical outcomes including mortality as well as morbidity is impacted by the presence of underlying chromosomal abnormalities. For example the underlying risk for poor neurodevelopmental outcomes may be modified by the impact of associated aneuploidy or genetic aberrations. These are important considerations impacting prognostication in prenatal counselling. There have been rapid advances in the area of genetic testing yet options are often limited in the prenatal period due to several reasons including need for invasive testing as well as limitations in insurance coverage and high out of pocket costs. In this study we propose a retrospective review of fetal diagnosis of congenital cardiac abnormality to 1. evaluate results of prenatal and postnatal genetic testing in this cohort 2. evaluate impact of genetic test results on fetal and neonatal outcomes. The findings of this study may direct future QI projects to drive change in prenatal genetic testing patterns and improved insurance coverage for more comprehensive genetic testing as well as help guide informed counselling for families. This project will need access to patient records both at UW/AFCH as well as Unity-Point Meriter Hospital. | 1 | Literature review, chart review, making a red cap database and analysis. Goal is to have an abstract and possibly a manuscript or this will lead to a QI project | Moderate | Familiarity with REDcap database creation, literature review | NA | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Unsure / Depends | Xiao Zhang PhD Clinical Research Scientist Pediatric Cardiology | Shardha Srinivasan, ssrinivasan3@wisc.edu -- Co-Mentor: Allie Kiley RN Fetal Cardiac Care Coordinator AKiley@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuciZWY19yNdOZ-EcbU2eFzhuZVJbYB7Idnazl35MBGIyPmN4l9NdB4TGzS4EJaG8ek | ||||
| ecowan@pediatrics.wisc.edu | Eileen | Cowan | MD | Associate Professor | 0 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | PEDI(atri)CS - Pediatric Education Development Initiative in Clinical Skills: Pediatric specific skills and foundational knowledge are underrepresented in many pre-clinical curricula, and students report feeling most prepared for adult internal medicine-based clinical experiences during core clinical rotations. As a result, students “hit the ground running” on clinical clerkships like internal medicine and can focus on applying their skills and knowledge to patient care. Clerkships such as pediatrics that are less well represented in the pre-clinical curriculum have the added challenge of teaching students the necessary foundational knowledge and skills during the clerkship despite those clerkships typically have less time than internal medicine. To facilitate the transition into core clinical rotations, we have set a goal to incorporate pediatric-specific patient care skills into the clinical skills curriculum in phase 1 at SMPH. We aim to accomplish this by developing ELO or hands-on/simulated pediatric clinical skill activities to supplement the existing clinical skills curriculum. ____________________________________________________________________________ Role - Research evidence-based medicine for clinical skills, perform literature review to identify existing curricula at other schools, design a scholarly curriculum evaluation plan, create clinical skills curriculum activities, develop plan for scholarly dissemination. May also include initial work on grant and IRB applications. Student will help develop a week-by-week project plan with frequent check-ins. ; IRB Status - N/A; Skills - Recommended: Organized, self-motivated, creative, independent, reliable, good time-management with ability to meet project deadlines, and proactive problem-solver | Neonatology and Newborn Nursery | Kirstin Nackers | nackers@pediatrics.wisc.edu | Pediatrics | Hospital Medicine and Complex Care | PEDI(atri)CS - Pediatric Education Development Initiative in Clinical Skills | Pediatric specific skills and foundational knowledge are underrepresented in many pre-clinical curricula, and students report feeling most prepared for adult internal medicine-based clinical experiences during core clinical rotations. As a result, students “hit the ground running” on clinical clerkships like internal medicine and can focus on applying their skills and knowledge to patient care. Clerkships such as pediatrics that are less well represented in the pre-clinical curriculum have the added challenge of teaching students the necessary foundational knowledge and skills during the clerkship despite those clerkships typically have less time than internal medicine. To facilitate the transition into core clinical rotations, we have set a goal to incorporate pediatric-specific patient care skills into the clinical skills curriculum in phase 1 at SMPH. We aim to accomplish this by developing ELO or hands-on/simulated pediatric clinical skill activities to supplement the existing clinical skills curriculum. | 0 | Research evidence-based medicine for clinical skills, perform literature review to identify existing curricula at other schools, design a scholarly curriculum evaluation plan, create clinical skills curriculum activities, develop plan for scholarly dissemination. May also include initial work on grant and IRB applications. Student will help develop a week-by-week project plan with frequent check-ins. | The student will primarily be working independently with regular check-ins with mentors. | Recommended: Organized, self-motivated, creative, independent, reliable, good time-management with ability to meet project deadlines, and proactive problem-solver | N/A | No | Yes | Student should plan to use their own computer for basic activities (literature reviews, cloud-based collaboration with mentor, etc.) | Not currently available to mentor other students | Yes | No | Kim Stevenson (kdstevenson@pediatrics.wisc.edu) and Rebecca Bound (rebecca.bound@wisc.edu) | Eileen Cowan, ecowan@pediatrics.wisc.edu -- Co-Mentor: Kirstin Nackers nackers@pediatrics.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucRhuy3v6uKiYfRXcD_VurYspkzstn4wUYvrIT7_fBYOOz1j0r3fYGC_XLHa_WsD2U | ||||
| jcralphe@pediatrics.wisc.edu | Carter | Ralphe | MD | Professor of Pediatrics / Chief, Pediatric Cardiology | 6.086.923.419 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Modeling inherited cardiomyopathy using human iPS cells: This Shapiro student summer project will focus on using human induced pluripotent stem cells that carry mutations that are known to cause hypertrophic cardiomyopathy. the student will learn how to differentiate these cells into cardiac cells and grow them in a three dimensional engineered heart model. With the model the student will learn how to measure contractile properties, and then isolate RNA and protein to examine gene expression profiles. The information from these experiments will help to identify how a specific mutation alters heart function and the early signals that lead to disease. The project is anticipated to generate data that the student will be able to submit as an abstract to upcoming scientific meetings and help prepare a manuscript for publication. ____________________________________________________________________________ Role - Will learn / reinforce RNA and protein isolation and perform QRT-PCR and Western immunoassays, will learn iPS cell differentiation and cardiomyocyte culture techinques. ; IRB Status - N/A; Skills - Basic molecular biology and tissue culture skills are desirable | Pediatric Cardiology | Modeling inherited cardiomyopathy using human iPS cells | This Shapiro student summer project will focus on using human induced pluripotent stem cells that carry mutations that are known to cause hypertrophic cardiomyopathy. the student will learn how to differentiate these cells into cardiac cells and grow them in a three dimensional engineered heart model. With the model the student will learn how to measure contractile properties, and then isolate RNA and protein to examine gene expression profiles. The information from these experiments will help to identify how a specific mutation alters heart function and the early signals that lead to disease. The project is anticipated to generate data that the student will be able to submit as an abstract to upcoming scientific meetings and help prepare a manuscript for publication. | 1 | Will learn / reinforce RNA and protein isolation and perform QRT-PCR and Western immunoassays, will learn iPS cell differentiation and cardiomyocyte culture techinques. | Dependent on experience. | Basic molecular biology and tissue culture skills are desirable | N/A | Yes | Yes | Yes | PhD students, UW undergraduates interested in research | No | No | Willem de Lange wjdelange@pediatrics.wisc.edu | Carter Ralphe, jcralphe@pediatrics.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudQCQWoog7RNFZv9XSP5FazFNV2I72jI5n57FYGIjXmSEYXDS3rCAvqQy7zN1gfRJs | ||||||||
| gtoia@uwhealth.org | Giuseppe | Toia | MD, MS | Assistant Professor of Radiology and Medical Physics | Radiology | Shorter term projects | Clinical Factors Associated with Positive Active Bleeder CT Angiography in the Emergency Setting: CT Angiography (CTA) is a well-described method of CT (computed tomography) in which both arterial and venous phases are obtained. This allows for multiphasic evaluation of the vasculature and gastrointestinal tract and helps identify active bleeding and or pseudoaneurysm formation. This is a specialized exam which takes longer to interpret given the higher number of images and should only be ordered when the pre-test probability for active bleed is high. We have noticed a significant uptrend in CTA orders from the emergency setting. Anecdotally, we do not believe this has translated to radiologists finding more bleeds. The purpose of this project is to analyze a list of factors (e.g., labs, medications, vitals, other imaging tests, procedures) that may correlate with a positive CTA study. This data could be used to create a multivariate model to predict the likelihood of positive CTAs. We have a database of over 300 patients needing chart review, some of which has been tackled by previous students and radiology trainees. Given the large patient cohort, we seek more help. Thank you for your potential interest in this project! ____________________________________________________________________________ Role - Chart review, data analysis and interpretation, abstract and potential manuscript preparation; IRB Status - Approved; Skills - Excel, Epic | Medical Physics | Clinical Factors Associated with Positive Active Bleeder CT Angiography in the Emergency Setting | CT Angiography (CTA) is a well-described method of CT (computed tomography) in which both arterial and venous phases are obtained. This allows for multiphasic evaluation of the vasculature and gastrointestinal tract and helps identify active bleeding and or pseudoaneurysm formation. This is a specialized exam which takes longer to interpret given the higher number of images and should only be ordered when the pre-test probability for active bleed is high. We have noticed a significant uptrend in CTA orders from the emergency setting. Anecdotally, we do not believe this has translated to radiologists finding more bleeds. The purpose of this project is to analyze a list of factors (e.g., labs, medications, vitals, other imaging tests, procedures) that may correlate with a positive CTA study. This data could be used to create a multivariate model to predict the likelihood of positive CTAs. We have a database of over 300 patients needing chart review, some of which has been tackled by previous students and radiology trainees. Given the large patient cohort, we seek more help. Thank you for your potential interest in this project! | 0 | Chart review, data analysis and interpretation, abstract and potential manuscript preparation | Student should be able | Excel, Epic | Approved | No | No (plan to use Dean's Office Funds) | No | Not currently available to mentor other students | No | No | Emily Johnson ejohnson5@uwhealth.org | Giuseppe Toia, gtoia@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf3nQZebB_t07NYCg032QUMw2D0P9JQ7nia1-IJM64cr4AL51TEu9k4dIHu8UgkK1Y | |||||||||
| ying.ge@wisc.edu | Ying | Ge | PhD | Professor | 608 | Cell and Regenerative Biology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Novel proteomics approach for precision medicine and clinical diagnosis: “Omics” technologies offer transformative insights to elucidate disease mechanisms and are the enabling force for precision medicine. In the post-genomic era, proteomics is the next frontier allowing an in-depth understanding of the function of cellular systems in diseases. Unlike the genome, the proteome is dynamic and highly complex due to alternative splicing and post-translational modifications (PTMs). Top-down mass spectrometry (MS)-based proteomics is the most powerful technology to comprehensively characterize proteoforms that arise from genetic variations, alternative splicing, and PTMs. We have made major advances in top-down proteomics for analysis of intact proteins directly purified from heart tissue, blood, and human pluripotent stem cell-derived cardiomyocytes (hPSC). Recently, we have developed ultra-high-sensitivity top-down proteomics for analysis of single cells that captures single muscle cell heterogeneity in large proteoforms (>200 kDa). Importantly, we have linked altered cardiac proteoforms to contractile dysfunction in heart diseases using animal models and human clinical samples. Furthermore, we are harnessing the power of innovative top-down proteomics technologies with patient-specific hPSC-derived cardiomyocytes (CMs) in engineered cardiac tissue to understand proteoform biology in cardiac diseases for precision medicine. We have developed innovative technologies that can provide transformative insights into the understanding of cardiovascular disease and regeneration, to identify new molecular targets for diagnosis, and ultimately provide novel treatments for cardiovascular diseases. Our ultimate goal is to translate the bench discoveries to the clinic for precision medicine. Here are two ongoing NIH-funded projects that we are looking for MD students to work together with our PhD students in the lab toward precision medicine and clinical diagnosis. 1). Identify proteomic and metabolic markers in patients of ischemic cardiomyopathy. We will systematically analyze a large cohort of explanted end-stage failing hearts due to ICM and compare to non-failing donor myocardium in both sexes. Proteomics and metabolic proteins as well as metabolites from human LV tissues will be analyzed by multi-omics. MD student will help link the omics data to clinical information. 2) Develop a comprehensive cardiac troponin assay for precision medicine. We will continue the development of a comprehensive and accurate proteoform-resolved clinical cTnI assay that can detect all cTnI proteoforms in blood for improved diagnosis of cardiovascular diseases. This will be built on the current successful collaboration between an MD student and PhD students. The current MD student has done a fantastic job and will graduate soon. So we are looking for a new MD student to continue this project. Ge group website: https://www.labs.wisc.edu/gelab/default.htm ____________________________________________________________________________ Role - The student is expected to 1) analyze clinical information; 2) work closely with other members in the group to integrate the clinical data with proteomics data, which will be used to for precision medicine and clinical diagnosis; IRB Status - approved; Skills - Basic biochemistry and biology skills; (Computational or informatics skills would be highly desired for project 1). | Novel proteomics approach for precision medicine and clinical diagnosis | “Omics” technologies offer transformative insights to elucidate disease mechanisms and are the enabling force for precision medicine. In the post-genomic era, proteomics is the next frontier allowing an in-depth understanding of the function of cellular systems in diseases. Unlike the genome, the proteome is dynamic and highly complex due to alternative splicing and post-translational modifications (PTMs). Top-down mass spectrometry (MS)-based proteomics is the most powerful technology to comprehensively characterize proteoforms that arise from genetic variations, alternative splicing, and PTMs. We have made major advances in top-down proteomics for analysis of intact proteins directly purified from heart tissue, blood, and human pluripotent stem cell-derived cardiomyocytes (hPSC). Recently, we have developed ultra-high-sensitivity top-down proteomics for analysis of single cells that captures single muscle cell heterogeneity in large proteoforms (>200 kDa). Importantly, we have linked altered cardiac proteoforms to contractile dysfunction in heart diseases using animal models and human clinical samples. Furthermore, we are harnessing the power of innovative top-down proteomics technologies with patient-specific hPSC-derived cardiomyocytes (CMs) in engineered cardiac tissue to understand proteoform biology in cardiac diseases for precision medicine. We have developed innovative technologies that can provide transformative insights into the understanding of cardiovascular disease and regeneration, to identify new molecular targets for diagnosis, and ultimately provide novel treatments for cardiovascular diseases. Our ultimate goal is to translate the bench discoveries to the clinic for precision medicine. Here are two ongoing NIH-funded projects that we are looking for MD students to work together with our PhD students in the lab toward precision medicine and clinical diagnosis. 1). Identify proteomic and metabolic markers in patients of ischemic cardiomyopathy. We will systematically analyze a large cohort of explanted end-stage failing hearts due to ICM and compare to non-failing donor myocardium in both sexes. Proteomics and metabolic proteins as well as metabolites from human LV tissues will be analyzed by multi-omics. MD student will help link the omics data to clinical information. 2) Develop a comprehensive cardiac troponin assay for precision medicine. We will continue the development of a comprehensive and accurate proteoform-resolved clinical cTnI assay that can detect all cTnI proteoforms in blood for improved diagnosis of cardiovascular diseases. This will be built on the current successful collaboration between an MD student and PhD students. The current MD student has done a fantastic job and will graduate soon. So we are looking for a new MD student to continue this project. Ge group website: https://www.labs.wisc.edu/gelab/default.htm | 2 | The student is expected to 1) analyze clinical information; 2) work closely with other members in the group to integrate the clinical data with proteomics data, which will be used to for precision medicine and clinical diagnosis | MD students will work with senior members in the group | Basic biochemistry and biology skills; (Computational or informatics skills would be highly desired for project 1). | approved | Yes | Yes | Yes | MPH students, PhD students | No | No | Courtney Griese | Ying Ge, ying.ge@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuee_z-VutEFiS-atrnXDPPYZTuh0P_elaG0z0K5i5cCsCn46mXg4T1TTrXwoUWav74 | |||||||||
| Gibson@surgery.wisc.edu | Angela | Gibson | MD,PhD | Associate Professor | 6.082.626.246 | Surgery | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Exploring burn wound progression using translational science: Patients with burn wounds may require surgical intervention for healing depending on the depth of injury. However, a delay in definitive treatment may occur, which is often because the initial diagnosis of burn depth is not indicative of the final depth due to burn wound progression. This project will combine clinical observations and ex vivo experiments to better understand burn wound progression and the impact of inflammation on this progression. Clinical aspects of the project will include daily visual assessments of burn wounds, collection of wound exudate during dressing changes, chart review, and development of a survey related to burn wound healing potential to distribute to burn surgeons nationwide. Basic science aspects of the project will include ex vivo experiments using human skin to evaluate the change in burn depth over time. There will be the opportunity to learn tissue handling skills, cell culture, staining, immunohistochemistry, and microscopy. Additional experiments may be planned using murine or swine models. ____________________________________________________________________________ Role - The student will participate in both clinical and basic science aspects of this project including obtaining daily photographs of burn wounds, assisting in the collection and analysis of wound fluid, chart review, tissue handling, cell culture, staining, immunohistochemistry, and microscopy.; IRB Status - approved; Skills - No specific prerequisite skills are required, though training in cell culture and possibly animal handling will be required once the position is obtained. | Acute Care and Regional General Surgery | Dr. Mary Junak (Surgery Resident) | mjunak@uwhealth.org | Surgery | Exploring burn wound progression using translational science | Patients with burn wounds may require surgical intervention for healing depending on the depth of injury. However, a delay in definitive treatment may occur, which is often because the initial diagnosis of burn depth is not indicative of the final depth due to burn wound progression. This project will combine clinical observations and ex vivo experiments to better understand burn wound progression and the impact of inflammation on this progression. Clinical aspects of the project will include daily visual assessments of burn wounds, collection of wound exudate during dressing changes, chart review, and development of a survey related to burn wound healing potential to distribute to burn surgeons nationwide. Basic science aspects of the project will include ex vivo experiments using human skin to evaluate the change in burn depth over time. There will be the opportunity to learn tissue handling skills, cell culture, staining, immunohistochemistry, and microscopy. Additional experiments may be planned using murine or swine models. | 0 | The student will participate in both clinical and basic science aspects of this project including obtaining daily photographs of burn wounds, assisting in the collection and analysis of wound fluid, chart review, tissue handling, cell culture, staining, immunohistochemistry, and microscopy. | moderate | No specific prerequisite skills are required, though training in cell culture and possibly animal handling will be required once the position is obtained. | approved | No | No (plan to use Dean's Office Funds) | Yes | PhD students | No | No | Dr. Aiping Liu (research scientist) | Angela Gibson, Gibson@surgery.wisc.edu -- Co-Mentor: Dr. Mary Junak (Surgery Resident) mjunak@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucAQwogkIwK-m3vD-ISTxXsDQjBQLF2sNOOrpqpMOq7f3opmmZ3nB6FXEp69_4vgzA | |||||
| emonroe@uwhealth.org | Eric | Monroe | M.D. | Associate Professor | Radiology | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Abdominal venolymphatic spatial relations: Assess the spectrum of normal spatial relationships of abdominal vasculature and the cisterna chyli depicted on cross sectional imaging studies (CT, MRI). Study conclusions will independently published and also foundational for the subsequent development of novel interventional devices and techniques for the management of lymphatic disorders. ____________________________________________________________________________ Role - Literature review, diagnostic imaging assessment, data analysis, manuscript authorship; IRB Status - Will be completed ahead of project start date; Skills - Data form creation, focused image analysis, basic data analysis | Interventional Radiology | Abdominal venolymphatic spatial relations | Assess the spectrum of normal spatial relationships of abdominal vasculature and the cisterna chyli depicted on cross sectional imaging studies (CT, MRI). Study conclusions will independently published and also foundational for the subsequent development of novel interventional devices and techniques for the management of lymphatic disorders. | 0 | Literature review, diagnostic imaging assessment, data analysis, manuscript authorship | Moderate | Data form creation, focused image analysis, basic data analysis | Will be completed ahead of project start date | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | No | No | lschelter@uwhealth.org , "Yang, Katie M" | Eric Monroe, emonroe@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuci0pDDDOV8XE4_lIqz8mhSZy8TUHLTVJNiKlNI5DWDZB26heL8sFKRHyBvVHB4Z6o | |||||||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, Hip Preservation Program; Director, Sports Medicine Fellowship | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | 3D CT/MRI correlation” & “Correlation of femoral and tibial torsion on CT: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific projects involve two collaborative projects with radiology. Both will be retrospective reviews of all patients who have undergone surgery for hip arthroscopy. Every hip arthroscopy patient undergoes an MRI and 3D CT scan prior to surgery. In the first study, we will compared 3D MRI scans (in those patients who had these specific sequences completed) to 3D CT scans. We are specifically looking into whether the 3D MRI hip reconstructions are a viable replacement for the 3D CT reconstruction of the hip, as this could eliminate the need for radiation associated with the 3D CT scans. In the second project, we will look at the 3D CT scan measurements of femoral version and analyze the relationship between tibial torsion on the ipsilateral leg. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar studies (none have been done in femoroacetabular impingement patients): Hodel S, Flury A, Hoch A, Zingg PO, Vlachopoulos L, Fucentese SF. The relationship between pelvic tilt, frontal, and axial leg alignment in healthy subjects. J Orthop Sci. 2023 Nov;28(6):1353-1358. doi: 10.1016/j.jos.2022.10.002. Epub 2022 Nov 3. PMID: 36336637. Qiao Y, Xu J, Zhang X, Ye Z, Wu C, Xu C, Zhao S, Zhao J. Correlation of Tibial Torsion With Lower Limb Alignment and Femoral Anteversion in Patients With Patellar Instability. Orthop J Sports Med. 2022 Dec 9;10(12):23259671221141484. doi: 10.1177/23259671221141484. PMID: 36532155; PMCID: PMC9747878. Nejima S, Akamatsu Y, Kobayashi H, Tsuji M, Mitsuhashi S, Sasaki T, Kumagai K, Inaba Y. Relationship between lower limb torsion and coronal morphologies of the femur and tibia in patients with medial knee osteoarthritis. BMC Musculoskelet Disord. 2020 Apr 17;21(1):254. doi: 10.1186/s12891-020-03286-2. PMID: 32303239; PMCID: PMC7165393. Cho KJ, Park KS, Shin YR, Yang HY, Yoon TR. Relationship between femoral anteversion and tibial torsion: CT evaluation of 38 unilateral developmental dysplasia of the hip patients. Hip Int. 2018 Sep;28(5):548-553. doi: 10.1177/1120700018759647. Epub 2018 Apr 23. PMID: 29683001. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our registry and for this project fall under our IRB umbrella protocol; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | 3D CT/MRI correlation” & “Correlation of femoral and tibial torsion on CT | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific projects involve two collaborative projects with radiology. Both will be retrospective reviews of all patients who have undergone surgery for hip arthroscopy. Every hip arthroscopy patient undergoes an MRI and 3D CT scan prior to surgery. In the first study, we will compared 3D MRI scans (in those patients who had these specific sequences completed) to 3D CT scans. We are specifically looking into whether the 3D MRI hip reconstructions are a viable replacement for the 3D CT reconstruction of the hip, as this could eliminate the need for radiation associated with the 3D CT scans. In the second project, we will look at the 3D CT scan measurements of femoral version and analyze the relationship between tibial torsion on the ipsilateral leg. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar studies (none have been done in femoroacetabular impingement patients): Hodel S, Flury A, Hoch A, Zingg PO, Vlachopoulos L, Fucentese SF. The relationship between pelvic tilt, frontal, and axial leg alignment in healthy subjects. J Orthop Sci. 2023 Nov;28(6):1353-1358. doi: 10.1016/j.jos.2022.10.002. Epub 2022 Nov 3. PMID: 36336637. Qiao Y, Xu J, Zhang X, Ye Z, Wu C, Xu C, Zhao S, Zhao J. Correlation of Tibial Torsion With Lower Limb Alignment and Femoral Anteversion in Patients With Patellar Instability. Orthop J Sports Med. 2022 Dec 9;10(12):23259671221141484. doi: 10.1177/23259671221141484. PMID: 36532155; PMCID: PMC9747878. Nejima S, Akamatsu Y, Kobayashi H, Tsuji M, Mitsuhashi S, Sasaki T, Kumagai K, Inaba Y. Relationship between lower limb torsion and coronal morphologies of the femur and tibia in patients with medial knee osteoarthritis. BMC Musculoskelet Disord. 2020 Apr 17;21(1):254. doi: 10.1186/s12891-020-03286-2. PMID: 32303239; PMCID: PMC7165393. Cho KJ, Park KS, Shin YR, Yang HY, Yoon TR. Relationship between femoral anteversion and tibial torsion: CT evaluation of 38 unilateral developmental dysplasia of the hip patients. Hip Int. 2018 Sep;28(5):548-553. doi: 10.1177/1120700018759647. Epub 2018 Apr 23. PMID: 29683001. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry and for this project fall under our IRB umbrella protocol | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucK-FHx96MmGCH8ixwK-jA4Sep2nMFaOy9wj8KaUjahsUinivdIYL5mqIAvTBWl1-U | ||||||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, Hip Preservation Program; Director, Sports Medicine Fellowship | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Contralateral hip range of motion improvement after hip arthroscopy surgery: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy surgery for the diagnosis of femoroacetabular impingement or periacetabular osteotomy for the diagnosis of hip dysplasia. We will report on the pre-and post-operative changes in hip range of motion, how it correlates to pre-and post-operative changes in hip/pelvic radiographs, and specifically focus on the contralateral (non-operative) hip and how motion changes after the affected hip has been “fixed.” This data is collected as part of our hip preservation registry, so the patient will be working with a large dataset with the help of our department biostatistician. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Horner NS, Rice MW, Sivasundaram L, Alter T, Ephron CG, Nho SJ. Staged Bilateral Hip Arthroscopy for Femoroacetabular Impingement Syndrome: Index Surgery Patient Reported Outcome Measures Predict Contralateral Surgery Results at 2 Years. Arthroscopy. 2023 May;39(5):1175-1182.e1. doi: 10.1016/j.arthro.2022.10.048. Epub 2022 Dec 8. PMID: 36653274. Lall AC. Editorial Commentary: Outcome After Ipsilateral Hip Arthroscopy Predicts Outcomes on the Contralateral Side, Regardless of Time Between Surgeries. Arthroscopy. 2023 May;39(5):1183-1184. doi: 10.1016/j.arthro.2023.01.021. PMID: 37019532. Dzidzishvili L, Kaplan DJ, Jan K, Mowers CC, Jackson GR, Chahla J. Increased Alpha Angles and Younger Age Increase the Risk of Contralateral Femoral Acetabular Impingement Syndrome Symptom Development and Surgical Intervention: A Systematic Review. Arthroscopy. 2023 Oct 10:S0749-8063(23)00811-3. doi: 10.1016/j.arthro.2023.10.004. Epub ahead of print. PMID: 37827434. Ankem HK, Diulus SC, Kyin C, Jimenez AE, Saks BR, Sabetian PW, Maldonado DR, Lall AC, Domb BG. Outcomes of Staged Bilateral Hip Arthroscopic Surgery in the Context of Femoroacetabular Impingement Syndrome: A Nested Matched-Pair Control Study Focusing on the Effect of Time Between Procedures. Am J Sports Med. 2022 Sep;50(11):2998-3008. doi: 10.1177/03635465221108955. Epub 2022 Jul 25. PMID: 35877152. Ward T, Hussain MM, Burns A, Pickering M, Neeman T, Perriman D, Smith P. Arthroscopic Femoral and Acetabular Osteoplasties Alter the In Vivo Hip Kinematics of Patients With Femoroacetabular Impingement. Arthrosc Sports Med Rehabil. 2022 Oct 12;4(6):e1961-e1968. doi: 10.1016/j.asmr.2022.08.004. PMID: 36579041; PMCID: PMC9791873. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our registry and for this project under our IRB umbrella protocol. ; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Contralateral hip range of motion improvement after hip arthroscopy surgery | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy surgery for the diagnosis of femoroacetabular impingement or periacetabular osteotomy for the diagnosis of hip dysplasia. We will report on the pre-and post-operative changes in hip range of motion, how it correlates to pre-and post-operative changes in hip/pelvic radiographs, and specifically focus on the contralateral (non-operative) hip and how motion changes after the affected hip has been “fixed.” This data is collected as part of our hip preservation registry, so the patient will be working with a large dataset with the help of our department biostatistician. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Horner NS, Rice MW, Sivasundaram L, Alter T, Ephron CG, Nho SJ. Staged Bilateral Hip Arthroscopy for Femoroacetabular Impingement Syndrome: Index Surgery Patient Reported Outcome Measures Predict Contralateral Surgery Results at 2 Years. Arthroscopy. 2023 May;39(5):1175-1182.e1. doi: 10.1016/j.arthro.2022.10.048. Epub 2022 Dec 8. PMID: 36653274. Lall AC. Editorial Commentary: Outcome After Ipsilateral Hip Arthroscopy Predicts Outcomes on the Contralateral Side, Regardless of Time Between Surgeries. Arthroscopy. 2023 May;39(5):1183-1184. doi: 10.1016/j.arthro.2023.01.021. PMID: 37019532. Dzidzishvili L, Kaplan DJ, Jan K, Mowers CC, Jackson GR, Chahla J. Increased Alpha Angles and Younger Age Increase the Risk of Contralateral Femoral Acetabular Impingement Syndrome Symptom Development and Surgical Intervention: A Systematic Review. Arthroscopy. 2023 Oct 10:S0749-8063(23)00811-3. doi: 10.1016/j.arthro.2023.10.004. Epub ahead of print. PMID: 37827434. Ankem HK, Diulus SC, Kyin C, Jimenez AE, Saks BR, Sabetian PW, Maldonado DR, Lall AC, Domb BG. Outcomes of Staged Bilateral Hip Arthroscopic Surgery in the Context of Femoroacetabular Impingement Syndrome: A Nested Matched-Pair Control Study Focusing on the Effect of Time Between Procedures. Am J Sports Med. 2022 Sep;50(11):2998-3008. doi: 10.1177/03635465221108955. Epub 2022 Jul 25. PMID: 35877152. Ward T, Hussain MM, Burns A, Pickering M, Neeman T, Perriman D, Smith P. Arthroscopic Femoral and Acetabular Osteoplasties Alter the In Vivo Hip Kinematics of Patients With Femoroacetabular Impingement. Arthrosc Sports Med Rehabil. 2022 Oct 12;4(6):e1961-e1968. doi: 10.1016/j.asmr.2022.08.004. PMID: 36579041; PMCID: PMC9791873. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry and for this project under our IRB umbrella protocol. | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufHw40t4zuPI1wnekB9ltuuqVtEzyEOSFh9tve3NtA028MK6TpxbB4LISTHrMyfdWo | ||||||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, Hip Preservation Program; Director, Sports Medicine Fellowship | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Periacetabular osteotomy (PAO) simulator for training and pre-operative planning purposes: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a collaboration with Dr. Josh Roth, in the department of mechanical and biomechanical engineering and the department of Orthopedic Surgery. We are developing a simulator for the periacetabular osteotomy (PAO) surgery, which is the gold standard operating for the treatment of developmental dysplasia of the hip. This simulator will serve two purposes: a 3D printout of the pelvis will allow surgeons/trainees to practice the osteotomy cuts and rotate the fragment into a desired position for fixation. A computational anatomic model will also allow surgeons during the pre-operative planning phase to create their desired correction on a computer prior to surgery. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Markhardt BK, Beilfuss MA, Hetzel SJ, Goodspeed DC, Spiker AM. 3D-printed models for periacetabular osteotomy surgical planning. J Hip Preserv Surg. 2021 Apr 12;7(4):748-754. doi: 10.1093/jhps/hnab024. PMID: 34377517; PMCID: PMC8349591. Fukushima K, Takahira N, Uchiyama K, Moriya M, Takaso M. Pre-operative simulation of periacetabular osteotomy via a three-dimensional model constructed from salt. SICOT J. 2017;3:14. doi: 10.1051/sicotj/2016051. Epub 2017 Feb 13. PMID: 28186873; PMCID: PMC5302880. Albers CE, Rogers P, Wambeek N, Ahmad SS, Yates PJ, Prosser GH. Preoperative planning for redirective, periacetabular osteotomies. J Hip Preserv Surg. 2017 Sep 14;4(4):276-288. doi: 10.1093/jhps/hnx030. PMID: 29250336; PMCID: PMC5721378. Park SJ, Lee SJ, Chen WM, Park JH, Cho YS, Shin T, Kwon SY. Computer-Assisted Optimization of the Acetabular Rotation in Periacetabular Osteotomy Using Patient's Anatomy-Specific Finite Element Analysis. Appl Bionics Biomech. 2018 Feb 4;2018:9730525. doi: 10.1155/2018/9730525. PMID: 29515650; PMCID: PMC5817303. Liu L, Siebenrock K, Nolte LP, Zheng G. Computer-Assisted Planning, Simulation, and Navigation System for Periacetabular Osteotomy. Adv Exp Med Biol. 2018;1093:143-155. doi: 10.1007/978-981-13-1396-7_12. PMID: 30306479. Beicker CR, Hudspeth LJ, Shanley E, Tokish JM, Folk J. The Intergluteal Fat Stripe in Patients With Hip Abductor Tears. Orthop J Sports Med. 2022 Feb 7;10(2):23259671211068030. doi: 10.1177/23259671211068030. PMID: 35155703; PMCID: PMC8832606. Kiarostami P, Dennler C, Roner S, Sutter R, Fürnstahl P, Farshad M, Rahm S, Zingg PO. Augmented reality-guided periacetabular osteotomy-proof of concept. J Orthop Surg Res. 2020 Nov 17;15(1):540. doi: 10.1186/s13018-020-02066-x. PMID: 33203429; PMCID: PMC7672946. Zeng G, Schmaranzer F, Degonda C, Gerber N, Gerber K, Tannast M, Burger J, Siebenrock KA, Zheng G, Lerch TD. MRI-based 3D models of the hip joint enables radiation-free computer-assisted planning of periacetabular osteotomy for treatment of hip dysplasia using deep learning for automatic segmentation. Eur J Radiol Open. 2020 Dec 18;8:100303. doi: 10.1016/j.ejro.2020.100303. PMID: 33364259; PMCID: PMC7753932. Shelton TJ, Monazzam S, Calafi A, Leshikar HB, Haus BM. Preoperative 3D Modeling and Printing for Guiding Periacetabular Osteotomy. J Pediatr Orthop. 2021 Mar 1;41(3):149-158. doi: 10.1097/BPO.0000000000001734. PMID: 33323878. Kriechling P, Leoty L, Fürnstahl P, Rahbani D, Zingg PO, Vlachopoulos L. A Statistical Shape Model-Based Analysis of Periacetabular Osteotomies: Technical Considerations to Achieve the Targeted Correction. J Bone Joint Surg Am. 2022 Jun 15;104(12):1107-1115. doi: 10.2106/JBJS.21.00454. Epub 2022 Apr 1. PMID: 35363641. Aitken HD, Westermann RW, Bartschat NI, Clohisy JC, Willey MC, Goetz JE. Effect of modeling femoral version and head-neck offset correction on computed contact mechanics in dysplastic hips treated with periacetabular osteotomy. J Biomech. 2022 Aug;141:111207. doi: 10.1016/j.jbiomech.2022.111207. Epub 2022 Jun 22. PMID: 35764011; PMCID: PMC9747059. Aitken HD, Miller A, Rivas DJL, Tatum M, Westermann RW, Willey MC, Goetz JE. Radiographically successful periacetabular osteotomy does not achieve optimal contact mechanics in dysplastic hips. Clin Biomech (Bristol, Avon). 2023 Apr;104:105928. doi: 10.1016/j.clinbiomech.2023.105928. Epub 2023 Mar 3. PMID: 36906984; PMCID: PMC10122705. Aitken HD, Miller A, Rivas DJ, Tatum M, Westermann RW, Willey MC, Goetz JE. Providing a computationally derived, mechanically optimised target correction during preoperative planning can improve joint contact mechanics of hip dysplasia treated with periacetabular osteotomy. Hip Int. 2023 Dec 10:11207000231212403. doi: 10.1177/11207000231212403. Epub ahead of print. PMID: 38073284. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) and the engineering PI (Dr. Roth) to discuss progress of the research as well as to follow a summer research curriculum created by the PIs. This curriculum is geared at introducing the student to clinical research and how to complete research projects. On-site, in person time will be spent with Dr. Roth in his lab and with his engineering students for a portion of the summer. ; IRB Status - IRB approval for our registry falls under our IRB umbrella protocol. The additional PAO simulator project is IRB-approved.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Josh Roth, PhD | roth@ortho.wisc.edu | Orthopedics and Rehabilitation | Biomedical engineering | Periacetabular osteotomy (PAO) simulator for training and pre-operative planning purposes | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a collaboration with Dr. Josh Roth, in the department of mechanical and biomechanical engineering and the department of Orthopedic Surgery. We are developing a simulator for the periacetabular osteotomy (PAO) surgery, which is the gold standard operating for the treatment of developmental dysplasia of the hip. This simulator will serve two purposes: a 3D printout of the pelvis will allow surgeons/trainees to practice the osteotomy cuts and rotate the fragment into a desired position for fixation. A computational anatomic model will also allow surgeons during the pre-operative planning phase to create their desired correction on a computer prior to surgery. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Markhardt BK, Beilfuss MA, Hetzel SJ, Goodspeed DC, Spiker AM. 3D-printed models for periacetabular osteotomy surgical planning. J Hip Preserv Surg. 2021 Apr 12;7(4):748-754. doi: 10.1093/jhps/hnab024. PMID: 34377517; PMCID: PMC8349591. Fukushima K, Takahira N, Uchiyama K, Moriya M, Takaso M. Pre-operative simulation of periacetabular osteotomy via a three-dimensional model constructed from salt. SICOT J. 2017;3:14. doi: 10.1051/sicotj/2016051. Epub 2017 Feb 13. PMID: 28186873; PMCID: PMC5302880. Albers CE, Rogers P, Wambeek N, Ahmad SS, Yates PJ, Prosser GH. Preoperative planning for redirective, periacetabular osteotomies. J Hip Preserv Surg. 2017 Sep 14;4(4):276-288. doi: 10.1093/jhps/hnx030. PMID: 29250336; PMCID: PMC5721378. Park SJ, Lee SJ, Chen WM, Park JH, Cho YS, Shin T, Kwon SY. Computer-Assisted Optimization of the Acetabular Rotation in Periacetabular Osteotomy Using Patient's Anatomy-Specific Finite Element Analysis. Appl Bionics Biomech. 2018 Feb 4;2018:9730525. doi: 10.1155/2018/9730525. PMID: 29515650; PMCID: PMC5817303. Liu L, Siebenrock K, Nolte LP, Zheng G. Computer-Assisted Planning, Simulation, and Navigation System for Periacetabular Osteotomy. Adv Exp Med Biol. 2018;1093:143-155. doi: 10.1007/978-981-13-1396-7_12. PMID: 30306479. Beicker CR, Hudspeth LJ, Shanley E, Tokish JM, Folk J. The Intergluteal Fat Stripe in Patients With Hip Abductor Tears. Orthop J Sports Med. 2022 Feb 7;10(2):23259671211068030. doi: 10.1177/23259671211068030. PMID: 35155703; PMCID: PMC8832606. Kiarostami P, Dennler C, Roner S, Sutter R, Fürnstahl P, Farshad M, Rahm S, Zingg PO. Augmented reality-guided periacetabular osteotomy-proof of concept. J Orthop Surg Res. 2020 Nov 17;15(1):540. doi: 10.1186/s13018-020-02066-x. PMID: 33203429; PMCID: PMC7672946. Zeng G, Schmaranzer F, Degonda C, Gerber N, Gerber K, Tannast M, Burger J, Siebenrock KA, Zheng G, Lerch TD. MRI-based 3D models of the hip joint enables radiation-free computer-assisted planning of periacetabular osteotomy for treatment of hip dysplasia using deep learning for automatic segmentation. Eur J Radiol Open. 2020 Dec 18;8:100303. doi: 10.1016/j.ejro.2020.100303. PMID: 33364259; PMCID: PMC7753932. Shelton TJ, Monazzam S, Calafi A, Leshikar HB, Haus BM. Preoperative 3D Modeling and Printing for Guiding Periacetabular Osteotomy. J Pediatr Orthop. 2021 Mar 1;41(3):149-158. doi: 10.1097/BPO.0000000000001734. PMID: 33323878. Kriechling P, Leoty L, Fürnstahl P, Rahbani D, Zingg PO, Vlachopoulos L. A Statistical Shape Model-Based Analysis of Periacetabular Osteotomies: Technical Considerations to Achieve the Targeted Correction. J Bone Joint Surg Am. 2022 Jun 15;104(12):1107-1115. doi: 10.2106/JBJS.21.00454. Epub 2022 Apr 1. PMID: 35363641. Aitken HD, Westermann RW, Bartschat NI, Clohisy JC, Willey MC, Goetz JE. Effect of modeling femoral version and head-neck offset correction on computed contact mechanics in dysplastic hips treated with periacetabular osteotomy. J Biomech. 2022 Aug;141:111207. doi: 10.1016/j.jbiomech.2022.111207. Epub 2022 Jun 22. PMID: 35764011; PMCID: PMC9747059. Aitken HD, Miller A, Rivas DJL, Tatum M, Westermann RW, Willey MC, Goetz JE. Radiographically successful periacetabular osteotomy does not achieve optimal contact mechanics in dysplastic hips. Clin Biomech (Bristol, Avon). 2023 Apr;104:105928. doi: 10.1016/j.clinbiomech.2023.105928. Epub 2023 Mar 3. PMID: 36906984; PMCID: PMC10122705. Aitken HD, Miller A, Rivas DJ, Tatum M, Westermann RW, Willey MC, Goetz JE. Providing a computationally derived, mechanically optimised target correction during preoperative planning can improve joint contact mechanics of hip dysplasia treated with periacetabular osteotomy. Hip Int. 2023 Dec 10:11207000231212403. doi: 10.1177/11207000231212403. Epub ahead of print. PMID: 38073284. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) and the engineering PI (Dr. Roth) to discuss progress of the research as well as to follow a summer research curriculum created by the PIs. This curriculum is geared at introducing the student to clinical research and how to complete research projects. On-site, in person time will be spent with Dr. Roth in his lab and with his engineering students for a portion of the summer. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry falls under our IRB umbrella protocol. The additional PAO simulator project is IRB-approved. | No | Yes | Yes | Not currently available to mentor other students | Yes | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Josh Roth, PhD roth@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufmYXCiWul2wrLzZl4q4xYmnACzuby4QVjSqG8BhZ7IfQxmAdHGA_wvFGpd9a58HCE | ||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, Hip Preservation Program; Director, Sports Medicine Fellowship | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Evaluating changes in the language used in letters of recommendations to describe male and female orthopaedic surgery residents over the past decade: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. This specific project has more of a focus on diversity in orthopaedic surgery, which is one of the least sex diverse fields in medicine (while the national average is 6% of orthopaedic surgeons are women, at the University of Wisconsin our department consists of approximately 25% female orthopaedic surgeons). We would like to look at the language used in the letters of recommendations in orthopaedic resident applications as in the sports fellowship applications based on the sex of the applicant. This study would be based on similar prior studies published (see citations below), however would be an “update” study analyzing the trends at our institution over the past decade. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Khan S, Kirubarajan A, Shamsheri T, Clayton A, Mehta G. Gender bias in reference letters for residency and academic medicine: a systematic review. Postgrad Med J. 2023 May 22;99(1170):272-278. Trix F, Psenka C.Exploringthecolorofglass: lettersofrecommendationforfemaleandmalemedicalfaculty.Discourse& Society2003;14:191–220. Powers A, Gerull KM, Rothman R, Klein SA, Wright RW, Dy CJ. Race- and Gender-Based Differences in Descriptions of Applicants in the Letters of Recommendation for Orthopaedic Surgery Residency. JB JS Open Access. 2020 Jun 26;5(3):e20.00023. doi: 10.2106/JBJS.OA.20.00023. PMID: 32803104; PMCID: PMC7386551. Kobayashi AN, Sterling RS, Tackett SA, Chee BW, Laporte DM, Humbyrd CJ. Are There Gender-based Differences in Language in Letters of Recommendation to an Orthopaedic Surgery Residency Program? Clin Orthop Relat Res. 2020 Jul;478(7):1400-1408. doi: 10.1097/CORR.0000000000001053. PMID: 31794493; PMCID: PMC7310286. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our registry falls under our IRB umbrella protocol. We will submit a separate IRB proposal for the specific project but expect IRB exemption. ; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Kathryn Williams | KWilliams@ortho.wisc.edu | Orthopedics and Rehabilitation | Foot & ankle | Evaluating changes in the language used in letters of recommendations to describe male and female orthopaedic surgery residents over the past decade | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. This specific project has more of a focus on diversity in orthopaedic surgery, which is one of the least sex diverse fields in medicine (while the national average is 6% of orthopaedic surgeons are women, at the University of Wisconsin our department consists of approximately 25% female orthopaedic surgeons). We would like to look at the language used in the letters of recommendations in orthopaedic resident applications as in the sports fellowship applications based on the sex of the applicant. This study would be based on similar prior studies published (see citations below), however would be an “update” study analyzing the trends at our institution over the past decade. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. The following papers represent similar/related studies: Khan S, Kirubarajan A, Shamsheri T, Clayton A, Mehta G. Gender bias in reference letters for residency and academic medicine: a systematic review. Postgrad Med J. 2023 May 22;99(1170):272-278. Trix F, Psenka C.Exploringthecolorofglass: lettersofrecommendationforfemaleandmalemedicalfaculty.Discourse& Society2003;14:191–220. Powers A, Gerull KM, Rothman R, Klein SA, Wright RW, Dy CJ. Race- and Gender-Based Differences in Descriptions of Applicants in the Letters of Recommendation for Orthopaedic Surgery Residency. JB JS Open Access. 2020 Jun 26;5(3):e20.00023. doi: 10.2106/JBJS.OA.20.00023. PMID: 32803104; PMCID: PMC7386551. Kobayashi AN, Sterling RS, Tackett SA, Chee BW, Laporte DM, Humbyrd CJ. Are There Gender-based Differences in Language in Letters of Recommendation to an Orthopaedic Surgery Residency Program? Clin Orthop Relat Res. 2020 Jul;478(7):1400-1408. doi: 10.1097/CORR.0000000000001053. PMID: 31794493; PMCID: PMC7310286. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry falls under our IRB umbrella protocol. We will submit a separate IRB proposal for the specific project but expect IRB exemption. | No | Yes | Yes | Not currently available to mentor other students | Yes | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Kathryn Williams KWilliams@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucfiWcU7-2ByYyNmQeOU0NneaqRMZAEO9WCC0flyfLp0XO22_TFdKh_AaD001A1haU | ||||
| npulia@wisc.edu | Nicole | Rogus-Pulia | PhD | Assistant Professor | 6.082.631.430 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Salivary Analysis in Patients with Head/Neck Cancer Treated with Radiation Therapy: The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders. Salivary dysfunction and dysphagia are important healthcare issues for patients with head/neck cancer treated with radiation therapy that result in poor quality of life and health consequences. This project involves analyzing saliva samples from patients who have undergone radiation treatment, with collections completed at multiple time points, using an enzyme-linked immunosorbent assay (ELISA). Training in conducting assays will be provided. This project will include analysis of ELISA data, with plans for abstract/manuscript preparation. SSBL website: https://ssbl.wisc.edu/ ____________________________________________________________________________ Role - Perform ELISAs of saliva samples collected from patients with head/neck cancer who have undergone radiation therapy. Training provided. Student will also manage data, assist with analysis, and prepare data for publication.; IRB Status - Approved; Skills - Wet lab experience helpful, but not required. | Geriatrics | Meredith Mackowicz-Torres | mmackowicz@medicine.wisc.edu | Medicine | Geriatrics | Salivary Analysis in Patients with Head/Neck Cancer Treated with Radiation Therapy | The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders. Salivary dysfunction and dysphagia are important healthcare issues for patients with head/neck cancer treated with radiation therapy that result in poor quality of life and health consequences. This project involves analyzing saliva samples from patients who have undergone radiation treatment, with collections completed at multiple time points, using an enzyme-linked immunosorbent assay (ELISA). Training in conducting assays will be provided. This project will include analysis of ELISA data, with plans for abstract/manuscript preparation. SSBL website: https://ssbl.wisc.edu/ | 0 | Perform ELISAs of saliva samples collected from patients with head/neck cancer who have undergone radiation therapy. Training provided. Student will also manage data, assist with analysis, and prepare data for publication. | Moderate | Wet lab experience helpful, but not required. | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Nicole Rogus-Pulia (npulia@wisc.edu), Sara Gustafson (segustafson@wisc.edu), Laure Bihannic (bihannic@wisc.edu) | Nicole Rogus-Pulia, npulia@wisc.edu -- Co-Mentor: Meredith Mackowicz-Torres mmackowicz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuepf-Q7eLKAjcCDIVjC6WqLZ3qHEgJjoEZIJ8nmxtW74qlDDFD_mxc5fUH5Cu0601U | ||||
| npulia@wisc.edu | Nicole | Rogus-Pulia | PhD | Assistant Professor | 6.082.631.430 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Quality of Life Swallowing Outcomes in Patients with Head/Neck Cancer Treated with Radiation Therapy: The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders. Salivary dysfunction and dysphagia are important healthcare issues for patients with head/neck cancer treated with radiation therapy that result in poor quality of life and health consequences. This project involves compiling patient-reported outcome data related to swallowing at various time points during and after treatment, organizing data for analysis, analyzing results, and preparing a manuscript. SSBL website: https://ssbl.wisc.edu/ ____________________________________________________________________________ Role - Student will compile and manage data, assist with analysis, and prepare data for publication.; IRB Status - Approved; Skills - Strong written communication skills | Geriatrics | Meredith Mackowicz-Torres | mmackowicz@medicine.wisc.edu | Medicine | Geriatrics | Quality of Life Swallowing Outcomes in Patients with Head/Neck Cancer Treated with Radiation Therapy | The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders. Salivary dysfunction and dysphagia are important healthcare issues for patients with head/neck cancer treated with radiation therapy that result in poor quality of life and health consequences. This project involves compiling patient-reported outcome data related to swallowing at various time points during and after treatment, organizing data for analysis, analyzing results, and preparing a manuscript. SSBL website: https://ssbl.wisc.edu/ | 0 | Student will compile and manage data, assist with analysis, and prepare data for publication. | Moderate | Strong written communication skills | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Nicole Rogus-Pulia (npulia@wisc.edu), Sara Gustafson (segustafson@wisc.edu), Laure Bihannic (bihannic@wisc.edu) | Nicole Rogus-Pulia, npulia@wisc.edu -- Co-Mentor: Meredith Mackowicz-Torres mmackowicz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueFHARbcutLsnuFvE3w6uhSoancjtd9N9JDeodz1QFxU912VDow5Zkv9QLHDyJAPVo | ||||
| npulia@wisc.edu | Nicole | Rogus-Pulia | PhD | Assistant Professor | 6.082.631.430 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Transitional Foods and Salivary Properties: The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders, including the role of saliva in eating and drinking. Transitional foods may be helpful for those with dysphagia, but the interaction with these foods and saliva may influence certain properties that affect the bolus formation for individuals with dysphagia. This project aims to characterize the rheological properties of transitional foods with the addition of saliva of high or low mucin content. Using a rheometer to measure extensional viscosity, as well as other testing procedures, the rheological properties of transitional foods and saliva will be investigated. These results will be collected, analyzed, and prepared for publication. SSBL website: https://ssbl.wisc.edu/ ____________________________________________________________________________ Role - Student will be trained in wet lab procedures, achieving competency in using a rheometer. In the wet lab, the student will perform analyses with transitional foods and saliva, compile and manage data, assist with analysis, and prepare data for publication.; IRB Status - Approved; Skills - Wet lab experience helpful, but not required. | Geriatrics | Meredith Mackowicz-Torres | mmackowicz@medicine.wisc.edu | Medicine | Geriatrics | Transitional Foods and Salivary Properties | The Swallowing and Salivary Bioscience Laboratory Salivary is a translational research program that focuses on the underlying factors contributing to swallowing disorders, including the role of saliva in eating and drinking. Transitional foods may be helpful for those with dysphagia, but the interaction with these foods and saliva may influence certain properties that affect the bolus formation for individuals with dysphagia. This project aims to characterize the rheological properties of transitional foods with the addition of saliva of high or low mucin content. Using a rheometer to measure extensional viscosity, as well as other testing procedures, the rheological properties of transitional foods and saliva will be investigated. These results will be collected, analyzed, and prepared for publication. SSBL website: https://ssbl.wisc.edu/ | 0 | Student will be trained in wet lab procedures, achieving competency in using a rheometer. In the wet lab, the student will perform analyses with transitional foods and saliva, compile and manage data, assist with analysis, and prepare data for publication. | Moderate | Wet lab experience helpful, but not required. | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Nicole Rogus-Pulia (npulia@wisc.edu), Sara Gustafson (segustafson@wisc.edu), Laure Bihannic (bihannic@wisc.edu) | Nicole Rogus-Pulia, npulia@wisc.edu -- Co-Mentor: Meredith Mackowicz-Torres mmackowicz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudgjTcErs3JHqt3SyblbmuTeu4sxEfRr1DNS3LXIR4F7rNR-bT5xISZCty-8rqt4MI | ||||
| 01/02/2024 | nkumar39@wisc.edu | Nilay | Kumar | MD | Assistant Professor | 2.055.401.971 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Incidence and Predictors of 30-day Readmissions following Hospitalization for COVID-19 : This project will use the 2020 Nationwide Readmissions Database to identify hospital admissions for a principal diagnosis of COVID-19. 30-day readmissions will be identified using a unique patient-level linkage variable supplied in the database. The most common causes of readmission will be identified. Multivariable regression modeling will be used to identify clinical, hospital-level and socioeconomic risk factors for readmissions. ____________________________________________________________________________ Role - literature review, interpreting data analysis, data visualization and tabulation, preparing abstract and poster; IRB Status - N/A ; Skills - Minimal | Hospital Medicine | Incidence and Predictors of 30-day Readmissions following Hospitalization for COVID-19 | This project will use the 2020 Nationwide Readmissions Database to identify hospital admissions for a principal diagnosis of COVID-19. 30-day readmissions will be identified using a unique patient-level linkage variable supplied in the database. The most common causes of readmission will be identified. Multivariable regression modeling will be used to identify clinical, hospital-level and socioeconomic risk factors for readmissions. | 0 | literature review, interpreting data analysis, data visualization and tabulation, preparing abstract and poster | Minimal | Minimal | N/A | No | No (plan to use Dean's Office Funds) | No | Not currently available to mentor other students | No | Yes | N/A | Nilay Kumar, nkumar39@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucuWW2qhcL5phD5FMEkMg2A1tSTxgWEio2f0fYIq8-8qrLMTtodZ2ryV2HhZL1OZgM | |||||||
| kbevil@wisc.edu | Kristin | Bevil | MD | Assistant Professor | 847 | Anesthesiology | Shorter term projects | Fascial Plane Block versus Thoracic Epidural for Renal Autotransplant Surgery: This project is a prospectively collected, retrospective analysis of fascial plane blocks with liposomal bupivacaine versus thoracic epidural in renal autotransplant surgery in non-opioid-dependent patients. Renal autotransplants are typical done for chronic pain conditions, which presents a challenge for perioperative pain control. Thoracic epidurals are the gold-standard, but since the FDA approval of liposomal bupivacaine, there has been lots of interest in its use as part of Enhanced Recovery After Surgery protocols. The student helping with this project will be helping with chart review/data collection. The project has already received IRB exemption. ____________________________________________________________________________ Role - Data collection; IRB Status - Approved-Exempt; Skills - Comfortable with Healthlink and Excel | Regional anesthesiology | Fascial Plane Block versus Thoracic Epidural for Renal Autotransplant Surgery | This project is a prospectively collected, retrospective analysis of fascial plane blocks with liposomal bupivacaine versus thoracic epidural in renal autotransplant surgery in non-opioid-dependent patients. Renal autotransplants are typical done for chronic pain conditions, which presents a challenge for perioperative pain control. Thoracic epidurals are the gold-standard, but since the FDA approval of liposomal bupivacaine, there has been lots of interest in its use as part of Enhanced Recovery After Surgery protocols. The student helping with this project will be helping with chart review/data collection. The project has already received IRB exemption. | 0 | Data collection | Comfortable with Healthlink and Excel | Approved-Exempt | No | Yes | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan, jasullivan@wisc.edu | Kristin Bevil, kbevil@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudW7JHCvI7nItBdAL-6gD6gU-yxytVE7GeOWDyhQDdkB05I4FK8y6lJDdSMmhaAz3M | |||||||||
| 01/02/2024 | chod@surgery.wisc.edu | Daniel | Cho | MD, PhD | Incidence of Orofacial Clefts and their Association with Environmental Contaminants and Sociodemographic Disparities in the State of Wisconsin | Surgery | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Incidence of Orofacial Clefts and their Association with Environmental Contaminants and Sociodemographic Disparities in the State of Wisconsin: Orofacial clefts (OFC) are a spectrum of congenital facial differences including clefts of the lip and palate, impacting 1 in 700 infants. These have significant physical, psychological and socio-economic impacts on patients and families. The multidisciplinary Craniofacial Anomalies Clinic (CFAC) at the American Family Children’s Hospital (AFCH) provides cleft care for a significant portion of Wisconsin. The providers have noted that there is a higher rate and unusual presentations of OFC in Wisconsin. A preliminary analysis of patients treated at AFCH revealed a 2:1 ratio of unilateral:bilateral clefts, which is a significant contrast to the expected 9:1 ratio. It is widely accepted that OFC result from the complex interplay between genetic and environmental factors but there is little data on the effect of environmental contaminants on the development of OFC. We hypothesize that there are high rates of environmental contamination in specific areas of Wisconsin, and that both environmental contamination and sociodemographic disparities will be associated with an increased incidence of OFC in specific areas of our state. We aim to assess the geographic distribution of OFC throughout the state of Wisconsin and potential association with known environmental contaminants in the region. ____________________________________________________________________________ Role - Data collection, data analysis, preparation of abstracts/manuscripts, presentation at local/regional/national conferences; interfacing with multidisciplinary research team; IRB Status - IRB exempt; Skills - Statistics experience preferred but not necessary | Plastic and Reconstructive Surgery | Catharine Garland | garland@surgery.wisc.edu | Surgery | Incidence of Orofacial Clefts and their Association with Environmental Contaminants and Sociodemographic Disparities in the State of Wisconsin | Orofacial clefts (OFC) are a spectrum of congenital facial differences including clefts of the lip and palate, impacting 1 in 700 infants. These have significant physical, psychological and socio-economic impacts on patients and families. The multidisciplinary Craniofacial Anomalies Clinic (CFAC) at the American Family Children’s Hospital (AFCH) provides cleft care for a significant portion of Wisconsin. The providers have noted that there is a higher rate and unusual presentations of OFC in Wisconsin. A preliminary analysis of patients treated at AFCH revealed a 2:1 ratio of unilateral:bilateral clefts, which is a significant contrast to the expected 9:1 ratio. It is widely accepted that OFC result from the complex interplay between genetic and environmental factors but there is little data on the effect of environmental contaminants on the development of OFC. We hypothesize that there are high rates of environmental contamination in specific areas of Wisconsin, and that both environmental contamination and sociodemographic disparities will be associated with an increased incidence of OFC in specific areas of our state. We aim to assess the geographic distribution of OFC throughout the state of Wisconsin and potential association with known environmental contaminants in the region. | 0 | Data collection, data analysis, preparation of abstracts/manuscripts, presentation at local/regional/national conferences; interfacing with multidisciplinary research team | Statistics experience preferred but not necessary | IRB exempt | No | Yes | Yes | Genetic Counseling students, MPH students, PhD students | No | Yes | N/A | Daniel Cho, chod@surgery.wisc.edu -- Co-Mentor: Catharine Garland garland@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuce_jOWBSmJClDDt4F399llzJ8KA3TOe01uMphnXY1pOyNYk8YP2vQK-87g-HEURQU | ||||||
| Day@ortho.wisc.edu | Molly | Day | MD | Assistant Professor | Orthopedics and Rehabilitation | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Influence of Bone Marrow Edema at Time of ACL Injury on 1-year Outcomes in Collegiate Athletes: Anterior cruciate ligament (ACL) injuries are devasting for collegiate athletes as they are season ending injuries, typically require surgical reconstruction (ACLR), and necessitate extensive rehabilitation for upwards of 9-12 months post-ACLR, with considerable variability in the rate of recovery. A common clinical finding at time of injury is the presence of bone marrow edema as a result of the high forces experienced during the pivot shift injury mechanism. It is unclear how the severity of bone marrow edema influences post-operative recovery and clinical outcomes. This project will leverage the Badger Athletic Performance (BAP) database to assess the relationship between the volume of bone marrow edema present at the time of anterior cruciate ligament (ACL) injury and clinical outcomes out to 1-year post-ACLR. Clinical outcomes of interest that are readily available in the BAP database include: running and jumping biomechanics, quadriceps neuromuscular performance, dual-energy X-ray absorptiometry scans, and patient-reported outcome measures. ____________________________________________________________________________ Role - The Shapiro scholar will be responsible for segmenting and extracting bone marrow edema volume from post-injury (pre-surgery) MRI scans, identifying athletes for inclusion in the analysis, compiling clinical outcomes data, performing basic statistical analyses to assess the association between clinical outcomes and bone marrow edema, and presenting findings to the BAP program members at the end of the summer program. In addition, the scholar will have the opportunity to observe BAP team testing and post-operative testing sessions. ; IRB Status - Approved; Skills - Medical imaging analysis experience and proficiency in excel preferred, but not required. | Kenneth Lee | KLee2@uwhealth.org | Radiology | Influence of Bone Marrow Edema at Time of ACL Injury on 1-year Outcomes in Collegiate Athletes | Anterior cruciate ligament (ACL) injuries are devasting for collegiate athletes as they are season ending injuries, typically require surgical reconstruction (ACLR), and necessitate extensive rehabilitation for upwards of 9-12 months post-ACLR, with considerable variability in the rate of recovery. A common clinical finding at time of injury is the presence of bone marrow edema as a result of the high forces experienced during the pivot shift injury mechanism. It is unclear how the severity of bone marrow edema influences post-operative recovery and clinical outcomes. This project will leverage the Badger Athletic Performance (BAP) database to assess the relationship between the volume of bone marrow edema present at the time of anterior cruciate ligament (ACL) injury and clinical outcomes out to 1-year post-ACLR. Clinical outcomes of interest that are readily available in the BAP database include: running and jumping biomechanics, quadriceps neuromuscular performance, dual-energy X-ray absorptiometry scans, and patient-reported outcome measures. | 0 | The Shapiro scholar will be responsible for segmenting and extracting bone marrow edema volume from post-injury (pre-surgery) MRI scans, identifying athletes for inclusion in the analysis, compiling clinical outcomes data, performing basic statistical analyses to assess the association between clinical outcomes and bone marrow edema, and presenting findings to the BAP program members at the end of the summer program. In addition, the scholar will have the opportunity to observe BAP team testing and post-operative testing sessions. | Scholar will be trained to complete the required tasks outlined in the student’s role. | Medical imaging analysis experience and proficiency in excel preferred, but not required. | Approved | No | No (plan to use Dean's Office Funds) | Yes | PhD students | No | No | McGuine@ortho.wisc.edu | Molly Day, Day@ortho.wisc.edu -- Co-Mentor: Kenneth Lee KLee2@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuepGDqGjNrhpHSzKx_N3NMUwnrjSADCFlTWYpZLS0DvzlgeKIwdNqbeoKZUBTdVCnM | |||||||
| 02/04/2024 | smahrt@pediatrics.wisc.edu | Megan | Moreno | MD, MSEd, MPH | Professor of Pediatrics | 608 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Brain, Behavior and Well-being: The Brain, Behavior, and WellBeing (B3) Study investigates how technology and digital media can influence health behaviors and well-being in adolescents. The purpose of this study is to address the urgent need to understand how technology and digital media use could impact adolescent development and health. This project's website is b3study.org and our research team site is www.smahrtresearch.com. ____________________________________________________________________________ Role - Research team member involved in data collection, analysis planning, recruitment and all aspects of this project. May have opportunity to get exposure to fMRI portion of study as well as abstract planning and writing. ; IRB Status - Approved; Skills - Exposure to social media is a benefit | General Pediatrics and Adolescent Medicine | Bradley Kerr | bkerr@wisc.edu | Pediatrics | General Pediatrics and Adolescent Medicine | Brain, Behavior and Well-being | The Brain, Behavior, and WellBeing (B3) Study investigates how technology and digital media can influence health behaviors and well-being in adolescents. The purpose of this study is to address the urgent need to understand how technology and digital media use could impact adolescent development and health. This project's website is b3study.org and our research team site is www.smahrtresearch.com. | 0 | Research team member involved in data collection, analysis planning, recruitment and all aspects of this project. May have opportunity to get exposure to fMRI portion of study as well as abstract planning and writing. | Our team does expect a degree of initiative and independence in all team member's work, but also provides a supportive environment to learn and ask questions. | Exposure to social media is a benefit | Approved | Yes | Yes | Yes | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | Christine Richards (crichards9@wisc.edu) | Megan Moreno, smahrt@pediatrics.wisc.edu -- Co-Mentor: Bradley Kerr bkerr@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucfurJcd3JlgwTFa_iaV8bplOXAx-xfqr45lNEDWB5mk2aJfbr5blB_Ta7FxSmM58I | |||
| 01/09/2024 | smahrt@pediatrics.wisc.edu | Megan | Moreno | MD, MSEd, MPH | Professor of Pediatrics | 608 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | American Academy of Pediatrics: This project is the American Academy of Pediatrics (AAP) Center of Excellence on Social Media and Youth Mental Health. Students will be fully immersed in work on this large national project alongside team members from UW Madison, U Michigan and the AAP. Duties will include addressing questions submitted by community members to the Center web portal using evidence based approaches, and being part of planning and implementing Center initiatives. The Center website is here: https://www.aap.org/en/patient-care/media-and-children/center-of-excellence-on-social-media-and-youth-mental-health/ ____________________________________________________________________________ Role - The student will get exposure and experiences across all aspects of this exciting Center of Excellence on Social Media and Youth Mental Health work. ; IRB Status - N/A; Skills - Literature review skills are a benefit | General pediatrics and adolescent medicine | Avery Salerno | aesalerno@wisc.edu | Pediatrics | General pediatrics and adolescent medicine | American Academy of Pediatrics | This project is the American Academy of Pediatrics (AAP) Center of Excellence on Social Media and Youth Mental Health. Students will be fully immersed in work on this large national project alongside team members from UW Madison, U Michigan and the AAP. Duties will include addressing questions submitted by community members to the Center web portal using evidence based approaches, and being part of planning and implementing Center initiatives. The Center website is here: https://www.aap.org/en/patient-care/media-and-children/center-of-excellence-on-social-media-and-youth-mental-health/ | 2 | The student will get exposure and experiences across all aspects of this exciting Center of Excellence on Social Media and Youth Mental Health work. | Independent work alongside team members to provdie support. | Literature review skills are a benefit | N/A | Yes | Yes | Yes | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | Christine Richards (crichards9@wisc.edu) | Megan Moreno, smahrt@pediatrics.wisc.edu -- Co-Mentor: Avery Salerno aesalerno@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuccMgNa30kUCsdBEU_9oTye7ajpFQkBPfbIcOZEz3kcNfaizgj571BdRfhqHJ-WreE | |||
| nmunjal@wisc.edu | Neil | Munjal | MD | Assistant Professor of Pediatrics | Pediatrics | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Neurodevelopmental Outcomes following Acquired Brain Injury: The Pediatric Brain Care Clinic at the Waisman Center is an interdisciplinary clinic for infants, children, and adolescents with, or at risk for, developmental and/or behavioral disabilities associated with an acquired brain injury. The two primary populations served are traumatic and non-traumatic spontaneous head injuries, ranging from mild to severe, and patients who have undergone cardiac surgery for congenital heart disease. In the BCC, patients receive a comprehensive evaluation including neurodevelopmental and neuropsychological testing batteries, a physical therapy evaluation, a school liaison evaluation, and a medical evaluation. While the BCC has existed for 10+ years, formal quantitative quality improvement data has only begun to be recorded in the past 2 years. With this relatively new quality database, we are exploring both descriptive analysis of outcomes of these two patient populations, and beginning to link neurodevelopmental outcomes to hospital and pre-morbid characteristics. Students working with the BCC team can expect to 1) learn about the pathophysiologic features that place patients at risk for neurological morbidity, 2) learn or enhance the skill to analyze quantitative data for population description using open source programming tools such as Python and R, 3) learn or enhance the ability to link datasets and generate hypotheses linking in-hospital features to outcomes and potentially participating in QI efforts to optimize outcomes, 4) receive opportunities to present their work at conferences geared towards pediatric cardiology, pediatric neurodevelopment, pediatric ICU medicine, or pediatric quality improvement. ____________________________________________________________________________ Role - Data Analyst - Load and process data, apply descriptive statistical analysis (both univariable and multivariable), perform database linkage. Students will also learn about techniques of manual and automated data entry into a quality improvement Redcap database; IRB Status - N/A; Skills - Beneficial: Prior work in data science, programming languages R or Python, but other experience is welcome too. | Pediatric Critical Care | Neurology | Pediatric Neurology | Jonathan Mietchen, PhD | mietchen@neurology.wisc.edu | Neurology | Neuropsychology | Neurodevelopmental Outcomes following Acquired Brain Injury | The Pediatric Brain Care Clinic at the Waisman Center is an interdisciplinary clinic for infants, children, and adolescents with, or at risk for, developmental and/or behavioral disabilities associated with an acquired brain injury. The two primary populations served are traumatic and non-traumatic spontaneous head injuries, ranging from mild to severe, and patients who have undergone cardiac surgery for congenital heart disease. In the BCC, patients receive a comprehensive evaluation including neurodevelopmental and neuropsychological testing batteries, a physical therapy evaluation, a school liaison evaluation, and a medical evaluation. While the BCC has existed for 10+ years, formal quantitative quality improvement data has only begun to be recorded in the past 2 years. With this relatively new quality database, we are exploring both descriptive analysis of outcomes of these two patient populations, and beginning to link neurodevelopmental outcomes to hospital and pre-morbid characteristics. Students working with the BCC team can expect to 1) learn about the pathophysiologic features that place patients at risk for neurological morbidity, 2) learn or enhance the skill to analyze quantitative data for population description using open source programming tools such as Python and R, 3) learn or enhance the ability to link datasets and generate hypotheses linking in-hospital features to outcomes and potentially participating in QI efforts to optimize outcomes, 4) receive opportunities to present their work at conferences geared towards pediatric cardiology, pediatric neurodevelopment, pediatric ICU medicine, or pediatric quality improvement. | 1 | Data Analyst - Load and process data, apply descriptive statistical analysis (both univariable and multivariable), perform database linkage. Students will also learn about techniques of manual and automated data entry into a quality improvement Redcap database | Moderate | Beneficial: Prior work in data science, programming languages R or Python, but other experience is welcome too. | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | No | N/A | Neil Munjal, nmunjal@wisc.edu -- Co-Mentor: Jonathan Mietchen, PhD mietchen@neurology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudb58tVRHc5BR7S4bS9C1-NoiJwHg9upxYEUohxWZqOgeHwO60ypd7P7pkD8AuBfms | |||
| 02/02/2024 | ascutler@wisc.edu | Abigail (Abby) | Cutler | MD, MPH | Assistant Professor | 207 | Obstetrics & Gynecology | Pending the status of these projects by the end of Summer 2024 and the student’s interest/abilities, there may be opportunities to continue research work throughout the next academic year. | Evaluating the Impact of Dobbs on patient care, clinical practice and medical training in Wisconsin : This project is an opportunity to participate in one or more ongoing research studies examining the impact of the post-Dobbs legal landscape in Wisconsin. 1. Evaluating Ob/Gyn Residents’ Experiences with Out-of-State Abortion Training Partnerships: Following the Dobbs decision, out-of-state rotations are important for training residents in abortion care. We are conducting a qualitative study using semi-structured interviews with ob/gyn residents who have recently completed an out-of-state rotation or hosted a visiting resident at their home institution to understand resident’s nuanced experiences with these training partnerships. 2. When Pregnancies Become Complicated: Consequences of Dobbs for Patients and ObGyn Physicians in Wisconsin: In June 2022, Dobbs v. Jackson Women’s Health Organization decision overturned Roe v. Wade putting into effect the 1849 Wisconsin state law criminalizing abortion provision. This UW Collaborative of Reproductive Equity-affiliated study is underway documenting ObGyn physician experiences caring for patients with pregnancy complications throughout the state of Wisconsin. The purpose of the study is to document the collateral damage and confusion in care provision following the Dobbs decision and a continually changing legal landscape. Drawing from in-depth interviews completed in the Fall of 2023, a Shapiro student would support qualitative analysis and manuscript writing. The opportunity would include the potential to publish and present findings at relevant conferences. 3. Changes in management of pregnancy of unknown location (PUL) among Wisconsin ObGyns following the June 2022 Dobbs decision: In June 2022, Dobbs v. Jackson Women’s Health Organization decision overturned Roe v. Wade putting into effect the 1849 Wisconsin state law criminalizing abortion provision. Multiple studies (Mercier 2015, Field 2022) have assessed changes in medical practice following the passage of laws that limit or restrict abortion care; however, there is a lack of literature on the extent to which abortion-restrictive legislation affects the management of PULs. This is a pilot survey study that seeks to assess changes in practice of PUL management among Wisconsin ObGyns following the Dobbs decision. Anecdotally, providers in WI have observed changes in their management of PUL. Our pilot study will investigate this observation and provide initial data for future qualitative studies. ____________________________________________________________________________ Role - This is an excellent project for a student interested in reproductive health and working with qualitative and/or survey data. We anticipate the student will be able to participate in multiple areas of the projects. Depending on the status of the projects by Summer 2024, possible activities might include: 1) Transcribing interview recordings; 2) Coding interview transcripts; 3) Qualitative data analysis; 4) Manuscript writing.; IRB Status - All three projects have been reviewed by the IRB and are deemed exempt. ; Skills - No specific skills required, but experience with qualitative data collection and analysis is welcome. | ASOG | Family Planning | Evaluating the Impact of Dobbs on patient care, clinical practice and medical training in Wisconsin | This project is an opportunity to participate in one or more ongoing research studies examining the impact of the post-Dobbs legal landscape in Wisconsin. 1. Evaluating Ob/Gyn Residents’ Experiences with Out-of-State Abortion Training Partnerships: Following the Dobbs decision, out-of-state rotations are important for training residents in abortion care. We are conducting a qualitative study using semi-structured interviews with ob/gyn residents who have recently completed an out-of-state rotation or hosted a visiting resident at their home institution to understand resident’s nuanced experiences with these training partnerships. 2. When Pregnancies Become Complicated: Consequences of Dobbs for Patients and ObGyn Physicians in Wisconsin: In June 2022, Dobbs v. Jackson Women’s Health Organization decision overturned Roe v. Wade putting into effect the 1849 Wisconsin state law criminalizing abortion provision. This UW Collaborative of Reproductive Equity-affiliated study is underway documenting ObGyn physician experiences caring for patients with pregnancy complications throughout the state of Wisconsin. The purpose of the study is to document the collateral damage and confusion in care provision following the Dobbs decision and a continually changing legal landscape. Drawing from in-depth interviews completed in the Fall of 2023, a Shapiro student would support qualitative analysis and manuscript writing. The opportunity would include the potential to publish and present findings at relevant conferences. 3. Changes in management of pregnancy of unknown location (PUL) among Wisconsin ObGyns following the June 2022 Dobbs decision: In June 2022, Dobbs v. Jackson Women’s Health Organization decision overturned Roe v. Wade putting into effect the 1849 Wisconsin state law criminalizing abortion provision. Multiple studies (Mercier 2015, Field 2022) have assessed changes in medical practice following the passage of laws that limit or restrict abortion care; however, there is a lack of literature on the extent to which abortion-restrictive legislation affects the management of PULs. This is a pilot survey study that seeks to assess changes in practice of PUL management among Wisconsin ObGyns following the Dobbs decision. Anecdotally, providers in WI have observed changes in their management of PUL. Our pilot study will investigate this observation and provide initial data for future qualitative studies. | 0 | This is an excellent project for a student interested in reproductive health and working with qualitative and/or survey data. We anticipate the student will be able to participate in multiple areas of the projects. Depending on the status of the projects by Summer 2024, possible activities might include: 1) Transcribing interview recordings; 2) Coding interview transcripts; 3) Qualitative data analysis; 4) Manuscript writing. | The student should be self-driven and able to independently create a daily schedule in order to complete their assigned tasks (for example, transcribing an assigned number of recordings per day). They will have regularly scheduled meetings with the mentor and/or other co-investigators/members of the research team and will be expected to meet specific goals for each meeting. | No specific skills required, but experience with qualitative data collection and analysis is welcome. | All three projects have been reviewed by the IRB and are deemed exempt. | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | Yes | Yes | Chelsea Gatica (MPA), cgatica@wisc.edu Corinne Marie Hale (PhD candidate; Research Assistant), cmhale@wisc.edu Maggie Williams, MD (PGY3), mwilliams26@uwhealth.org Naomi Roselar, MD (PGY2), nroselaar@uwhealth.org | Abigail (Abby) Cutler, ascutler@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueoF70BGq7oV3TvDM0ASShYasqUpvaMXhhAwMRIboYou1-5vxehrQRmY1jzKHlEEac | ||||||
| sleeth@wisc.edu | Carolyn | Sleeth | MD, MPH | Assistant Professor of Pediatrics | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Health consequences of chronic school absenteeism: Chronic school absenteeism is a growing problem, especially in the post-COVID landscape. There have been some studies that link missing school with adverse health affects, both physically and mentally, but there is a lack of comprehensive lit reviews summarizing this topic. My academic work focuses on school health and school/health systems communication, so better understanding this important topic will help to drive future partnerships and/or interventions. ____________________________________________________________________________ Role - Develop search terms, conduct literature search, and assist with writing a narrative review; IRB Status - N/A; Skills - Comfortable with PubMed and other databases | General Pediatric and Adolescent Medicine | Health consequences of chronic school absenteeism | Chronic school absenteeism is a growing problem, especially in the post-COVID landscape. There have been some studies that link missing school with adverse health affects, both physically and mentally, but there is a lack of comprehensive lit reviews summarizing this topic. My academic work focuses on school health and school/health systems communication, so better understanding this important topic will help to drive future partnerships and/or interventions. | 1 | Develop search terms, conduct literature search, and assist with writing a narrative review | Comfortable with PubMed and other databases | N/A | No | No (plan to use Dean's Office Funds) | No | MPH students | No | Yes | N/A | Carolyn Sleeth, sleeth@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnud8pG19uYcxhr4dsphCKuBB0uZEFLGpI38dUaGbkT1kHSCs65y5V0OvH-lGAPupU9Q | ||||||||||
| carrascomccaul@neurology.wisc.edu | Melisa | Carrasco | MD PhD | Assistant Professor | 6.085.772.415 | Neurology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Shapiro Summer Research Intern - Waisman Center and Department of Neurology: Overview: We are excited to invite applications for the Summer Research Intern position as part of the UW School of Medicine and Public Health (SMPH) Shapiro Summer Research Program. The Summer Research Program offers a unique opportunity for a medical student to actively participate in a research project under the mentorship of faculty at both the Waisman Center and the Department of Neurology. A research opportunity is available for a project centered around children with perinatal brain injuries. The research aims to explore the correlation between neonatal MRI and infant resting EEG at 6 and 12 months of age. This project provides an exceptional chance for a medical student to contribute to meaningful advancements in pediatric neurology and gain hands-on experience working with infants with perinatal brain injuries and their families. Project PIs: Melisa Carrasco McCaul, MD PhD Bernadette Gillick, PhD, MSPT, PT Direct Project Mentor: Cameron Casey, PhD TREES Web (Lab): https://neurology.wisc.edu/research-and-labs/trees-lab/ Pediatric Neuromodulation Web (Lab): https://pnl.waisman.wisc.edu/ ____________________________________________________________________________ Role - Data collection and analysis. ; IRB Status - IRB in place.; Skills - NA | Pediatric Neurology | Other | Waisman Center | Bernadette Gillick, PhD, MSPT, PT | bgillick@wisc.edu | Other | Waisman Center | Shapiro Summer Research Intern - Waisman Center and Department of Neurology | Overview: We are excited to invite applications for the Summer Research Intern position as part of the UW School of Medicine and Public Health (SMPH) Shapiro Summer Research Program. The Summer Research Program offers a unique opportunity for a medical student to actively participate in a research project under the mentorship of faculty at both the Waisman Center and the Department of Neurology. A research opportunity is available for a project centered around children with perinatal brain injuries. The research aims to explore the correlation between neonatal MRI and infant resting EEG at 6 and 12 months of age. This project provides an exceptional chance for a medical student to contribute to meaningful advancements in pediatric neurology and gain hands-on experience working with infants with perinatal brain injuries and their families. Project PIs: Melisa Carrasco McCaul, MD PhD Bernadette Gillick, PhD, MSPT, PT Direct Project Mentor: Cameron Casey, PhD TREES Web (Lab): https://neurology.wisc.edu/research-and-labs/trees-lab/ Pediatric Neuromodulation Web (Lab): https://pnl.waisman.wisc.edu/ | 1 | Data collection and analysis. | Mentored experience. Prior experience in EEG and cognitive development would be ideal but not required. | NA | IRB in place. | Yes | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students | No | No | N/A | Melisa Carrasco, carrascomccaul@neurology.wisc.edu -- Co-Mentor: Bernadette Gillick, PhD, MSPT, PT bgillick@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudQqRGgp-FXq4kBBs93q8PybyBjZhdma3N6LOAnNb_09bb6vTUIu2JtYJo3ldxVAyM | ||
| fallahian@wisc.edu | Whitney | Fallahian | MD | Assistant Professor | 907 | Anesthesiology | Shorter term projects, Research Electives for credit | General Anesthesia vs Monitored Anesthesia Care During Mechanical Thrombectomy for Acute Stroke Treatment: Ischemic stroke accounts for nearly 1 in 19 deaths in the United States, ranking it fifth among all causes of death. Methods of acute stroke treatment are continuously evolving, with endovascular thrombectomy considered the gold standard. However, the anesthetic management of patients undergoing thrombectomy remains controversial. Multiple studies have shown that monitored anesthesia care (MAC) or procedural sedation leads to better outcomes compared to general anesthesia (GA), while others have shown no difference. We are performing a retrospective study comparing GA vs MAC obtained from a review of patients from the University of Wisconsin from 2017-2023 presenting with ischemic stroke who underwent mechanical thrombectomy. Our primary endpoint is functional outcome as measured by Modified Rankin Score (MRS) at 90 days. Secondary endpoints included in-hospital death, death at 90 days, time to procedure start, time to recanalization, total procedure duration, successful revascularization, ICU length of stay and total hospital length of stay. The project will mainly entail data collection and entry as well as working with our statician to analyze the data and then write up the findings for a peer- reviewed journal article. ____________________________________________________________________________ Role - The role of the students will involve data collection and entry, working with our department statician to analyze the data and then begin to write up the finding for a peer-reviewed journal article.; IRB Status - Exempt; Skills - Familiar with Excel | Neuroanesthesia | Corey Amlong | caamlong@wisc.edu | Anesthesiology | Neuroanesthesia | General Anesthesia vs Monitored Anesthesia Care During Mechanical Thrombectomy for Acute Stroke Treatment | Ischemic stroke accounts for nearly 1 in 19 deaths in the United States, ranking it fifth among all causes of death. Methods of acute stroke treatment are continuously evolving, with endovascular thrombectomy considered the gold standard. However, the anesthetic management of patients undergoing thrombectomy remains controversial. Multiple studies have shown that monitored anesthesia care (MAC) or procedural sedation leads to better outcomes compared to general anesthesia (GA), while others have shown no difference. We are performing a retrospective study comparing GA vs MAC obtained from a review of patients from the University of Wisconsin from 2017-2023 presenting with ischemic stroke who underwent mechanical thrombectomy. Our primary endpoint is functional outcome as measured by Modified Rankin Score (MRS) at 90 days. Secondary endpoints included in-hospital death, death at 90 days, time to procedure start, time to recanalization, total procedure duration, successful revascularization, ICU length of stay and total hospital length of stay. The project will mainly entail data collection and entry as well as working with our statician to analyze the data and then write up the findings for a peer- reviewed journal article. | 0 | The role of the students will involve data collection and entry, working with our department statician to analyze the data and then begin to write up the finding for a peer-reviewed journal article. | Moderate to Significant | Familiar with Excel | Exempt | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan | Whitney Fallahian, fallahian@wisc.edu -- Co-Mentor: Corey Amlong caamlong@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueDmwpEyhj8qMXQUxd4CnkV7sy82dJ61QJBwOUx2ZN-oAQEm7K-Urk3H2fgZx1Z3A8 | ||||
| rtstriker@wisc.edu | rob | striker | MD/PhD | Associate Professor | 608 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Infectious cause of epilepsy: examine records from UKbiobank of people that have epilepsy and either do or do not have serologic evidence of Toxoplasmosis infection. Based on meta analysis from other countries we hypothesize this data set (several fold larger than any previously examined) will show those with serologic evidence of toxo exposure will have a ~4 fold higher risk of epilepsy. Data from UK biobank already shows for the first time that similiar to mouse studies toxo infection results in slightly smaller brains. This will be the first study with enough data that we can perhaps say how long after a toxo infection does the increase in epilepsy last, and does toxo increase all types of epilepsy or only certain focal types. ____________________________________________________________________________ Role - examine records from UKbiobank of people that have epilepsy and either do or do not have serologic evidence of Toxoplasmosis infection. Based on meta analysis from other countries we hypothesize this data set (several fold larger than any previously examined) will show those with serologic evidence of toxo exposure will have a ~4 fold higher risk of epilepsy. Data from UK biobank already shows for the first time that similiar to mouse studies toxo infection results in slightly smaller brains. This will be the first study with enough data that we can perhaps say how long after a toxo infection does the increase in epilepsy last, and does toxo increase all types of epilepsy or only certain focal types.; IRB Status - exempt; Skills - Excel, rudimentary statistics helpful but statisticians are involved | infectious diseases | Elizabeth Felton, Assistant Professor of Neurology | felton@neurology.wisc.edu | Neurology | Infectious cause of epilepsy | examine records from UKbiobank of people that have epilepsy and either do or do not have serologic evidence of Toxoplasmosis infection. Based on meta analysis from other countries we hypothesize this data set (several fold larger than any previously examined) will show those with serologic evidence of toxo exposure will have a ~4 fold higher risk of epilepsy. Data from UK biobank already shows for the first time that similiar to mouse studies toxo infection results in slightly smaller brains. This will be the first study with enough data that we can perhaps say how long after a toxo infection does the increase in epilepsy last, and does toxo increase all types of epilepsy or only certain focal types. | 0 | examine records from UKbiobank of people that have epilepsy and either do or do not have serologic evidence of Toxoplasmosis infection. Based on meta analysis from other countries we hypothesize this data set (several fold larger than any previously examined) will show those with serologic evidence of toxo exposure will have a ~4 fold higher risk of epilepsy. Data from UK biobank already shows for the first time that similiar to mouse studies toxo infection results in slightly smaller brains. This will be the first study with enough data that we can perhaps say how long after a toxo infection does the increase in epilepsy last, and does toxo increase all types of epilepsy or only certain focal types. | much of the work can be done at home, but I will meet with you weekly and there is a graduate student involved | Excel, rudimentary statistics helpful but statisticians are involved | exempt | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, UW undergraduates interested in research | No | Yes | N/A | rob striker, rtstriker@wisc.edu -- Co-Mentor: Elizabeth Felton, Assistant Professor of Neurology felton@neurology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufFqCcF_cStIo5nP0Qt979N3LDK-vKqlERnul80_A633YIKJoTiIwhihVGYXAVpvKg | |||||
| lgober@wisc.edu | Leah | Gober | MD | Resident, Vascular Surgery | 7.064.903.835 | Surgery | Shorter term projects | Aortic Dissection: Medical versus Surgical Management : The mainstay of managing acute descending thoracic aortic dissection (AD-TAD) is ill-defined, with some centers pursing a conservative approach and others performing prophylactic surgical intervention. This study seeks to understand factors that affect outcomes after TAD and determine patient-specific factors that predict progression. ____________________________________________________________________________ Role - Chart review, image review, manuscript preparation; IRB Status - Approved; Skills - Access to epic, basic scientific writing skills, basic image review skills | Vascular | Courtney Morgan | morganc@surgery.wisc.edu | Surgery | Vascular | Aortic Dissection: Medical versus Surgical Management | The mainstay of managing acute descending thoracic aortic dissection (AD-TAD) is ill-defined, with some centers pursing a conservative approach and others performing prophylactic surgical intervention. This study seeks to understand factors that affect outcomes after TAD and determine patient-specific factors that predict progression. | 1 | Chart review, image review, manuscript preparation | Moderate | Access to epic, basic scientific writing skills, basic image review skills | Approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | N/A | Leah Gober, lgober@wisc.edu -- Co-Mentor: Courtney Morgan morganc@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucjBpBC2yWtVMDybxCQ0tt9yR9BF8utBpb0ffZ34ii17aUOzWRWd9ErBCnOzUElzL8 | ||||
| 02/01/2024 | lhouser@pediatrics.wisc.edu | Laura | Houser | MD | Professor, Director of Advocacy | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Children, Youth, and the Dane County Community Health Need Assessment: This Shapiro student will play an integral role in analyzing primary data related to children, youth, and their families as part of the 2024 Dane County Community Health Needs Assessment (CHNA). Every three years Dane County’s local health systems partner to complete a comprehensive assessment of the community’s health needs. CHNA activities include primary data collection via key informant interviews, focus groups, community meetings, and surveys with community experts, health experts, caregivers, and patients. After primary and secondary data is analyzed, the local health systems collaboratively identify top health priority areas that, in turn, inform each institution’s strategic planning and community health improvement initiatives for the following three years. In the spring and summer of 2024 UW Health, the American Family Children’s Hospital, and the Department of Pediatrics will be working in collaboration with the other local health systems to enhance efforts to collect and analyze children and youth health-focused data as a part of the 2024 Dane County CHNA. This presents an opportunity for a Shapiro scholar to participate in applied community health research with a focus on the pediatric population. ____________________________________________________________________________ Role - The Shapiro student will help analyze and present qualitative data for the pediatric components of the Community Health Needs Assessment (CHNA). Primary data will be collected via key informant interviews, focus groups, community meetings, and surveys. As a culminating experience, the student will collaborate with Department of Pediatrics and UW Health office of Population Health staff to develop a summary report outlining the major themes of the data for several audiences, including the School of Medicine and Public Health’s Pediatric Services Council and Healthy Dane collaborative partners.; IRB Status - N/A; Skills - Qualitative research methods and analysis (Preferred: Experience transcribing and coding recorded conversations such as informant interviews, focus groups, and community meetings); Knowledge of foundational elements of public health, children’s health, population health, and/or community health | General Pediatrics and Adolescent Medicine | Shawn Koval, MA - Pediatric Community Health Improvement Manager (UW Health - Office of Population Health) | skoval@uwhealth.org | Other | Children, Youth, and the Dane County Community Health Need Assessment | This Shapiro student will play an integral role in analyzing primary data related to children, youth, and their families as part of the 2024 Dane County Community Health Needs Assessment (CHNA). Every three years Dane County’s local health systems partner to complete a comprehensive assessment of the community’s health needs. CHNA activities include primary data collection via key informant interviews, focus groups, community meetings, and surveys with community experts, health experts, caregivers, and patients. After primary and secondary data is analyzed, the local health systems collaboratively identify top health priority areas that, in turn, inform each institution’s strategic planning and community health improvement initiatives for the following three years. In the spring and summer of 2024 UW Health, the American Family Children’s Hospital, and the Department of Pediatrics will be working in collaboration with the other local health systems to enhance efforts to collect and analyze children and youth health-focused data as a part of the 2024 Dane County CHNA. This presents an opportunity for a Shapiro scholar to participate in applied community health research with a focus on the pediatric population. | 0 | The Shapiro student will help analyze and present qualitative data for the pediatric components of the Community Health Needs Assessment (CHNA). Primary data will be collected via key informant interviews, focus groups, community meetings, and surveys. As a culminating experience, the student will collaborate with Department of Pediatrics and UW Health office of Population Health staff to develop a summary report outlining the major themes of the data for several audiences, including the School of Medicine and Public Health’s Pediatric Services Council and Healthy Dane collaborative partners. | Moderate | Qualitative research methods and analysis (Preferred: Experience transcribing and coding recorded conversations such as informant interviews, focus groups, and community meetings); Knowledge of foundational elements of public health, children’s health, population health, and/or community health | N/A | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | Yes | Dr. Jess Babal (babal@pediatrics.wisc.edu); Adrian Jones (ajones3@uwhealth.org); Dr. Michelle Kelly (michelle.kelly@wisc.edu); Brad Kerr (bkerr@wisc.edu); Dr. Megan Moreno (moreno@wisc.edu) | Laura Houser, lhouser@pediatrics.wisc.edu -- Co-Mentor: Shawn Koval, MA - Pediatric Community Health Improvement Manager (UW Health - Office of Population Health) skoval@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufyRAIH2eqIvgXYEJZFYHpV4-AMXzOIaUhkJvPQK2_tkJBFFZ70VLv542HXSb_Z0D0 | |||||
| 02/05/2024 | otrc@ortho.wisc.edu | Paul | Whiting | MD | Dr. | 0 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Treatment of Segmental Bone Loss After Orthopaedic Trauma: Prospects of Treatment with Antibiotic Cement Spacer without Revision Bone Grafting: Segmental bone loss following orthopaedic trauma or infection is a challenging clinical scenario. One treatment modality involves placing an antibiotic cement spacer in the location of a segmental bone defect and later filling this area with bone grafting. However, sometimes bone healing can occur around the spacer, thus avoiding the need for another surgical procedure. This Shapiro summer research project involves performing a retrospective chart review looking at the use of antibiotic cement spacers as a form of definitive treatment for segmental bone loss. Data collected will include short-and-long-term clinical and radiographic outcomes for patients with segmental bone loss treated with antibiotic cement spacers, as well as revision surgery rates/outcomes, functional outcomes, and patient satisfaction. ____________________________________________________________________________ Role - The student will perform a literature review on the subject and in the process, draft an introduction for the research manuscript. Throughout the summer, the student will perform retrospective chart reviews of patients eligible for inclusion in the study. This will involve reviewing clinical progress notes, operative reports, and radiology reports, along with basic interpretation of radiographs and CT scans. The student will also work closely with our departmental statistician to plan and later analyze any statistical analyses relevant to the study. The student will also work toward drafting a full manuscript later in the summer, along with preparing a poster for the Shapiro Fall Research Symposium. Finally, there will be opportunities for the student to shadow Orthopaedic surgeons in clinic and in the operating room throughout the summer.; IRB Status - Approved; Skills - Proficiency in Excel, medical chart review/navigating EHR, ability to learn and apply basic X-ray interpretation skills, attention to detail and data organization and analysis, effective oral and communication skills, independent problem solving skills | Orthopedic Trauma | N/A | Dr. Justin Lapow (PGY-2 resident) | Jlapow@uwhealth.org | Orthopedics and Rehabilitation | Orthopedic Trauma | Treatment of Segmental Bone Loss After Orthopaedic Trauma: Prospects of Treatment with Antibiotic Cement Spacer without Revision Bone Grafting | Segmental bone loss following orthopaedic trauma or infection is a challenging clinical scenario. One treatment modality involves placing an antibiotic cement spacer in the location of a segmental bone defect and later filling this area with bone grafting. However, sometimes bone healing can occur around the spacer, thus avoiding the need for another surgical procedure. This Shapiro summer research project involves performing a retrospective chart review looking at the use of antibiotic cement spacers as a form of definitive treatment for segmental bone loss. Data collected will include short-and-long-term clinical and radiographic outcomes for patients with segmental bone loss treated with antibiotic cement spacers, as well as revision surgery rates/outcomes, functional outcomes, and patient satisfaction. | 0 | The student will perform a literature review on the subject and in the process, draft an introduction for the research manuscript. Throughout the summer, the student will perform retrospective chart reviews of patients eligible for inclusion in the study. This will involve reviewing clinical progress notes, operative reports, and radiology reports, along with basic interpretation of radiographs and CT scans. The student will also work closely with our departmental statistician to plan and later analyze any statistical analyses relevant to the study. The student will also work toward drafting a full manuscript later in the summer, along with preparing a poster for the Shapiro Fall Research Symposium. Finally, there will be opportunities for the student to shadow Orthopaedic surgeons in clinic and in the operating room throughout the summer. | As described above (and below), the student will be expected to work fairly independently on chart reviews after receiving appropriate training from the faculty mentor, orthopaedic resident (co-mentor), and our clinical research coordinator. Ongoing oversight and mentoring will be provided throughout the summer. | Proficiency in Excel, medical chart review/navigating EHR, ability to learn and apply basic X-ray interpretation skills, attention to detail and data organization and analysis, effective oral and communication skills, independent problem solving skills | Approved | No | Yes | Yes | Not currently available to mentor other students | No | No | Kris Sladky, Ortho Trauma Research Coordinator – sladky@ortho.wisc.edu; otrc@ortho.wisc.edu Dr. Paul Whiting – whiting@ortho.wisc.edu Dr. Justin Lapow – Jlapow@uwhealth.org | Paul Whiting, otrc@ortho.wisc.edu -- Co-Mentor: Dr. Justin Lapow (PGY-2 resident) Jlapow@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuexbloHccn_Ou7OWtwRLUom2rnEGFhRVzf0-7XlUNzOhwL1YItF9Re9UAGSI4xT-SU | ||
| 02/12/2024 | bcacioppo@wisc.edu | Brian | Cacioppo | MD | Doctor | 6.189.770.399 | Anesthesiology | Shorter term projects, Research Electives for credit | Transversus Abdominal Plane (TAP) Blocks with Liposomal Bupivacaine in Kidney Transplant Recipients: The push for multi-modal and opioid-limiting perioperative pain management strategies has been felt across all surgical specialties, including transplant surgery. According to a study that was published in 2018 in the American Journal of Transplantation not only are patients who undergo kidney transplantation at higher risk of developing long-term opioid dependence, but also the presence of persistent opioid use following surgery may influence long-term graft function and survival. Given this relatively new information, the utilization of multi-modal pain management for patients undergoing renal transplantation is of growing importance. One of the many tools at our disposal is perioperative nerve blockade. The Transversus Abdominis Plane (TAP) block, which was originally described in the literature in 2007, has been shown to be beneficial at reducing opioid requirements, decreasing opioid related side-effects, decreasing time to discharge, and increasing patient satisfaction in patients undergoing abdominal surgical procedures including C-sections, which continues to be the most common abdominal procedure in the United States. These ultrasound-guided nerve blocks utilize longer acting local anesthetic medication such as bupivacaine to provide intraoperative and postoperative analgesia for 6-18 hours. Additionally, with the development of liposomal bupivacaine, analgesic effects of TAP blocks can be extended beyond 24hours. Though this intervention has been found to be beneficial for a variety of abdominal procedures, there is little data demonstrating the same benefits in the renal transplantation population. Within the past 2 years the University of Wisconsin Department of Anesthesiology, in conjunction with Transplant Surgery, has begun implementing the standardization of perioperative bilateral TAP blocks with liposomal bupivacaine in most scheduled kidney transplant recipients, with the exception of after-hours procedures. This study is a retrospective chart review investigating the effect of perioperative bilateral single-shot TAP blocks with liposomal bupivacaine on the renal transplant recipient population in reducing opioid requirements and opioid-related negative outcomes (hospital stay, nausea, vomiting, etc.), as well as potential effects on graft function and survival. ____________________________________________________________________________ Role - The medical student will continue data collection via retrospective chart review that is already underway. This will involve reviewing kidney transplantation records in Epic and recording whether or not a TAP block was performed and their pain scores/total opioid doses for a total of 48 post-procedure. To aid in their understanding of anesthesia record review and the postoperative pain needs of kidney transplant patients, the students have to option of shadowing me in the OR during a kidney transplantation procedure. Upon completion of data collection, the student will work with biostatisticians from the transplant surgery department to analyze the data. The goal will be to submit a publication to a peer-reviewed journal and present a poster at ASA or similar Anesthesiology conference.; IRB Status - Approved; Skills - N/A | Regional and Acute Pain | Transversus Abdominal Plane (TAP) Blocks with Liposomal Bupivacaine in Kidney Transplant Recipients | The push for multi-modal and opioid-limiting perioperative pain management strategies has been felt across all surgical specialties, including transplant surgery. According to a study that was published in 2018 in the American Journal of Transplantation not only are patients who undergo kidney transplantation at higher risk of developing long-term opioid dependence, but also the presence of persistent opioid use following surgery may influence long-term graft function and survival. Given this relatively new information, the utilization of multi-modal pain management for patients undergoing renal transplantation is of growing importance. One of the many tools at our disposal is perioperative nerve blockade. The Transversus Abdominis Plane (TAP) block, which was originally described in the literature in 2007, has been shown to be beneficial at reducing opioid requirements, decreasing opioid related side-effects, decreasing time to discharge, and increasing patient satisfaction in patients undergoing abdominal surgical procedures including C-sections, which continues to be the most common abdominal procedure in the United States. These ultrasound-guided nerve blocks utilize longer acting local anesthetic medication such as bupivacaine to provide intraoperative and postoperative analgesia for 6-18 hours. Additionally, with the development of liposomal bupivacaine, analgesic effects of TAP blocks can be extended beyond 24hours. Though this intervention has been found to be beneficial for a variety of abdominal procedures, there is little data demonstrating the same benefits in the renal transplantation population. Within the past 2 years the University of Wisconsin Department of Anesthesiology, in conjunction with Transplant Surgery, has begun implementing the standardization of perioperative bilateral TAP blocks with liposomal bupivacaine in most scheduled kidney transplant recipients, with the exception of after-hours procedures. This study is a retrospective chart review investigating the effect of perioperative bilateral single-shot TAP blocks with liposomal bupivacaine on the renal transplant recipient population in reducing opioid requirements and opioid-related negative outcomes (hospital stay, nausea, vomiting, etc.), as well as potential effects on graft function and survival. | 0 | The medical student will continue data collection via retrospective chart review that is already underway. This will involve reviewing kidney transplantation records in Epic and recording whether or not a TAP block was performed and their pain scores/total opioid doses for a total of 48 post-procedure. To aid in their understanding of anesthesia record review and the postoperative pain needs of kidney transplant patients, the students have to option of shadowing me in the OR during a kidney transplantation procedure. Upon completion of data collection, the student will work with biostatisticians from the transplant surgery department to analyze the data. The goal will be to submit a publication to a peer-reviewed journal and present a poster at ASA or similar Anesthesiology conference. | After completing the appropriate training, the student will be able to function independently reviewing charts | N/A | Approved | No | No (plan to use Dean's Office Funds) | Students will just need access to Epic | Not currently available to mentor other students | No | No | N/A | Brian Cacioppo, bcacioppo@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufyZPvHUtYEGaokTpbxzIQ89ZiE8_woUWbYhdbLNVYr6AtSx4wxiSznS5OdNKW4cL8 | |||||||
| elfenbein@surgery.wisc.edu | Dawn | Elfenbein | MD | Associate Professor | Surgery | Shorter term projects | Surgeons who Meditate: Identifying the effects of contemplative practice on surgeons: This will be a qualitative project interviewing surgeons who engage in contemplative practices (e.g. meditation, yoga). The aim of this project is to identify how these practices effect surgical practice. Contemplative practices such as mindfulness train the mind to cultivate awareness of thoughts, emotions, and sensations, to regulate emotions, and enhance perspectives of self and others. Studies show that practices such as mindfulness-based interventions are effective at reducing stress and burnout in healthcare professionals as well as enhancing performance in high-stress populations. Early empirical evidence show mindfulness-based interventions in surgical training are feasible and may lower stress. However, the effects of these practices can go beyond stress and burnout, and there is a need to identify those potential effects to understand how these practices can be used to train surgeons. This project will fill that knowledge gap by investigating perspectives of experienced contemplative practitioners in the field of surgery to identify how these practices inform their surgical practice. ____________________________________________________________________________ Role - The student will assist with qualitative interviewing and data analysis. They will also have the potential to take part in literature review and abstract and manuscript writing if they wish. ; IRB Status - IRB approved; Skills - None required, experience with qualitative research preferred | Endocrine Surgery | Sydney Tan, MD General Surgery Resident & Primary Care Research Fellow | stan@uwhealth.org | Surgery | General Surgery | Surgeons who Meditate: Identifying the effects of contemplative practice on surgeons | This will be a qualitative project interviewing surgeons who engage in contemplative practices (e.g. meditation, yoga). The aim of this project is to identify how these practices effect surgical practice. Contemplative practices such as mindfulness train the mind to cultivate awareness of thoughts, emotions, and sensations, to regulate emotions, and enhance perspectives of self and others. Studies show that practices such as mindfulness-based interventions are effective at reducing stress and burnout in healthcare professionals as well as enhancing performance in high-stress populations. Early empirical evidence show mindfulness-based interventions in surgical training are feasible and may lower stress. However, the effects of these practices can go beyond stress and burnout, and there is a need to identify those potential effects to understand how these practices can be used to train surgeons. This project will fill that knowledge gap by investigating perspectives of experienced contemplative practitioners in the field of surgery to identify how these practices inform their surgical practice. | 1 | The student will assist with qualitative interviewing and data analysis. They will also have the potential to take part in literature review and abstract and manuscript writing if they wish. | None required, experience with qualitative research preferred | IRB approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Unsure / Depends | NA | Dawn Elfenbein, elfenbein@surgery.wisc.edu -- Co-Mentor: Sydney Tan, MD General Surgery Resident & Primary Care Research Fellow stan@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf-0PM9s0QXSP-y6bAfSIR1z2bJ9BG-Oq_2p2X1bXDjRtleDWOjm_0gAurhTwkSCck | ||||||
| otrc@ortho.wisc.edu | Jacquelyn | Dunahoe | MD | Dr. | 6.086.303.137 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Risks of Intertrochanteric Femur Fracture versus Femoral Neck Fracture in the Setting of Arthritis: Hip fractures are one of the most common orthopedic injuries. Timely treatment of these fractures is critical do decrease patients morbidity and mortality. The term hip fracture is used to describe both intertrochanteric femur fractures and femoral neck fractures. Intertrochanteric femur fractures are often treated with operative fixation where as femoral neck fractures are treated with arthroplasty. There is a general sense among orthopedic surgeons that patients with arthritis are more likely to sustain an intertrochanteric femur fracture rather than a femoral neck fracture. This has not previously been evaluated in the literature. The purpose of this project is to evaluate arthritis presence in patients who sustained a hip fracture and underwent operative treatment for their hip fracture. The student retrospectively evaluate patients XRs for arthritis, fracture type, and operative treatment. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Drs. Jacquelyn Dunahoe (primary mentor) and/or Paul Whiting (co- mentor). ____________________________________________________________________________ Role - - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission ; IRB Status - Approved; Skills - Proficiency in excel, medical chart review/navigating EHR, attention to detail and data organization and analysis, effective oral and communication skills, independent problem solving skills | Ortho Trauma | Dr. Paul Whiting | whiting@ortho.wisc.edu | Risks of Intertrochanteric Femur Fracture versus Femoral Neck Fracture in the Setting of Arthritis | Hip fractures are one of the most common orthopedic injuries. Timely treatment of these fractures is critical do decrease patients morbidity and mortality. The term hip fracture is used to describe both intertrochanteric femur fractures and femoral neck fractures. Intertrochanteric femur fractures are often treated with operative fixation where as femoral neck fractures are treated with arthroplasty. There is a general sense among orthopedic surgeons that patients with arthritis are more likely to sustain an intertrochanteric femur fracture rather than a femoral neck fracture. This has not previously been evaluated in the literature. The purpose of this project is to evaluate arthritis presence in patients who sustained a hip fracture and underwent operative treatment for their hip fracture. The student retrospectively evaluate patients XRs for arthritis, fracture type, and operative treatment. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Drs. Jacquelyn Dunahoe (primary mentor) and/or Paul Whiting (co- mentor). | 0 | - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission | Full | Proficiency in excel, medical chart review/navigating EHR, attention to detail and data organization and analysis, effective oral and communication skills, independent problem solving skills | Approved | No | Yes | Yes | Not currently available to mentor other students | No | No | Kris Sladky (Research Coordinator) - otrc@ortho.wisc.edu | Jacquelyn Dunahoe, otrc@ortho.wisc.edu -- Co-Mentor: Dr. Paul Whiting whiting@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueErmXs6b_h8uT1ZcjBMltm6s2lZIDBTTMIQrM5O_Q22zzUd1i_xz0MemhfKW43jws | ||||||
| 03/01/2024 | sarah.davis@wisc.edu | Sarah | Davis | JD / MPA | Clinical Professor of Law / Director Center for Patient Partnerships | 608 | Other | Shorter term projects, Always happy to consider projects with med students interested in health advocacy and patient experiences research | Advocacy for Patients with Disabilities: Creating an Evidence-Based Provider Toolkit to Increase Health Equity: Patients with disabilities are a nationally recognized population with health disparities. Barriers to care are multifactorial and can include difficulty accessing physical clinic environments, negative attitudes, lack of knowledge,¬¬ and insufficient time.1,2 In addition to usual medical care, patients often need access to disability specific resources (therapy, equipment, etc.). Providers play a key role in supporting access to these necessary resources, including writing Letters of Medical Necessity and supporting prior authorization and coverage denials. This role can be challenging for providers who are unfamiliar with the process and constrained by time allotted for office visits. There may be other unidentified challenges as well. The first goal of this project is to assess all known potential barriers or challenges to caring for patients with disabilities that exist for providers and whether and how they could be addressed through creation of resources (an advocacy toolkit). The focus of the study will be primary care. This information will be used to guide creation of an advocacy toolkit utilizing the expertise of physicians who specialize in the care of patients with disabilities and advocates at the Center for Patient Partnerships. The goal of the toolkit is to build capacity in providers and care teams to mitigate barriers to quality care and resource access for patients with disabilities, with the long-term goal of improving health equity. 1. Lagu T, Haywood C, Reimold K, DeJong C, Walker Sterling R, Iezzoni LI. ‘I Am Not The Doctor For You’: Physicians’ Attitudes About Caring for People with Disabilities. Health Aff (Milwood). 2002 Oct; 41(10):1387-1395. 2. Common Barriers to Participation Experienced by People with Disabilities. Centers for Disease Control and Prevention. Updated Sept 16, 2020. Accessed Feb 16, 2024. https://www.cdc.gov/ncbddd/disabilityandhealth/disability-barriers.html More information about the Center for Patient Partnerships, our research, and programing at patientpartnerships.wisc.edu. ____________________________________________________________________________ Role - Creation of a survey for primary care physicians to determine components of an advocacy toolkit that would be beneficial with the final goal being creation of an advocacy toolkit. The project includes creation of the survey, deployment, evaluation of results, literature review, and toolkit creation. The initial role will focus on the survey and determining what would be most beneficial to include in an advocacy toolkit. The student may have the opportunity to participate in dissemination activities.; IRB Status - No current IRB, we will apply for exempt status.; Skills - Attention to detail, effective oral and written communication skills. Proficiency or willingness to learn in literature review, IRB application, survey design, data analysis, and summary of findings. As needed student will be provided with training materials and resources at the UW Survey Center and Health Sciences Library. | Law / Center for Patient Partnerships | Medicine | Med Sciences (teach Selective) | Melissa Villegas | mvillegas3@wisc.edu | Pediatrics | Advocacy for Patients with Disabilities: Creating an Evidence-Based Provider Toolkit to Increase Health Equity | Patients with disabilities are a nationally recognized population with health disparities. Barriers to care are multifactorial and can include difficulty accessing physical clinic environments, negative attitudes, lack of knowledge,¬¬ and insufficient time.1,2 In addition to usual medical care, patients often need access to disability specific resources (therapy, equipment, etc.). Providers play a key role in supporting access to these necessary resources, including writing Letters of Medical Necessity and supporting prior authorization and coverage denials. This role can be challenging for providers who are unfamiliar with the process and constrained by time allotted for office visits. There may be other unidentified challenges as well. The first goal of this project is to assess all known potential barriers or challenges to caring for patients with disabilities that exist for providers and whether and how they could be addressed through creation of resources (an advocacy toolkit). The focus of the study will be primary care. This information will be used to guide creation of an advocacy toolkit utilizing the expertise of physicians who specialize in the care of patients with disabilities and advocates at the Center for Patient Partnerships. The goal of the toolkit is to build capacity in providers and care teams to mitigate barriers to quality care and resource access for patients with disabilities, with the long-term goal of improving health equity. 1. Lagu T, Haywood C, Reimold K, DeJong C, Walker Sterling R, Iezzoni LI. ‘I Am Not The Doctor For You’: Physicians’ Attitudes About Caring for People with Disabilities. Health Aff (Milwood). 2002 Oct; 41(10):1387-1395. 2. Common Barriers to Participation Experienced by People with Disabilities. Centers for Disease Control and Prevention. Updated Sept 16, 2020. Accessed Feb 16, 2024. https://www.cdc.gov/ncbddd/disabilityandhealth/disability-barriers.html More information about the Center for Patient Partnerships, our research, and programing at patientpartnerships.wisc.edu. | 1 | Creation of a survey for primary care physicians to determine components of an advocacy toolkit that would be beneficial with the final goal being creation of an advocacy toolkit. The project includes creation of the survey, deployment, evaluation of results, literature review, and toolkit creation. The initial role will focus on the survey and determining what would be most beneficial to include in an advocacy toolkit. The student may have the opportunity to participate in dissemination activities. | Literature review will be completed independently with direction from mentors and librarian. The student will work with feedback from mentors to develop the survey. | Attention to detail, effective oral and written communication skills. Proficiency or willingness to learn in literature review, IRB application, survey design, data analysis, and summary of findings. As needed student will be provided with training materials and resources at the UW Survey Center and Health Sciences Library. | No current IRB, we will apply for exempt status. | No | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | Yes | Curran Cauldwood Cauldwood@wisc.edu | Sarah Davis, sarah.davis@wisc.edu -- Co-Mentor: Melissa Villegas mvillegas3@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueTUCSPpLE0W0P5sQ9k0JXnRC1CG4_CuljJOx5PC-vklOJ3awc5Net9GZxphPyD_xk | ||
| cakelm@wisc.edu | Cynthia | Kelm-Nelson | PhD | Scientist III | 414 | Surgery | Shorter term projects, Research Electives for credit | Treatments of vocal communication deficits in a Parkinson rat model : Parkinsons disease (PD) is the second most common age-related neurological disorder that dramatically affects health-related quality of life of the patient as well as places a substantial burden on caregivers and the healthcare system. As the current population ages, the prevalence is expected to double by 2030, affecting twice as many men as women. The hallmark of PD in the central nervous system is death of dopaminergic neurons in the substantia nigra which corresponds to the classic disease-associated movement disorders; however, in most cases, neuron death precedes clinical presentation of motor signs. The onset of the disease occurs at least a decade prior to diagnosis leaving a loss in therapeutic opportunity. Widespread sensorimotor deficits, including early-onset vocal communication impairments (e.g. dysphonia, dysarthria), impact 90% of individuals with PD. Despite a significant negative health impact, management of vocal dysfunction in PD is restricted by a disconnect between current treatments and an understanding of the underlying early disease pathology, resulting in a critical gap in knowledge that limits patient treatment. Additionally, there are no specific biomarkers test to diagnose PD. The primary objective of our lab’s current work is to identify early stage (prodromal) gene biomarkers and pathways linked to vocalization and that are involved in the early stages of disease. Our lab models early-stage vocal motor behavioral deficits using a phosphatase and tensin homolog (PTEN)-induced putative kinase 1 knockout (Pink1-/-) rat as well as rat neuron cell culture. Opportunities in the lab for summer 2023 include: 1. Drug repurposing and cell culture. Previously generated RNA-sequencing datasets have identified enriched genetic pathways and differentially expressed genes that are dysregulated in the Pink1-/- rat model of PD and relate to vocal production. In vitro, drugs, already identified via computational drug repurposing, will be applied to Pink1-/- neuron cell cultures. Corresponding molecular assays will be performed (IF, WB, PCR). 2. Using stereotaxic coordinates to perform a site-specific injection into vocal motor nuclei in the rat brain. 3. Piloting the effects of a TNF-a blocker in the rat model of PD. ____________________________________________________________________________ Role - Primary researcher ; IRB Status - N/A; Skills - We are able to train extensively on basic laboratory skills. Animal handling may be required. | Otolaryngology-Head and Neck Surgery | Treatments of vocal communication deficits in a Parkinson rat model | Parkinsons disease (PD) is the second most common age-related neurological disorder that dramatically affects health-related quality of life of the patient as well as places a substantial burden on caregivers and the healthcare system. As the current population ages, the prevalence is expected to double by 2030, affecting twice as many men as women. The hallmark of PD in the central nervous system is death of dopaminergic neurons in the substantia nigra which corresponds to the classic disease-associated movement disorders; however, in most cases, neuron death precedes clinical presentation of motor signs. The onset of the disease occurs at least a decade prior to diagnosis leaving a loss in therapeutic opportunity. Widespread sensorimotor deficits, including early-onset vocal communication impairments (e.g. dysphonia, dysarthria), impact 90% of individuals with PD. Despite a significant negative health impact, management of vocal dysfunction in PD is restricted by a disconnect between current treatments and an understanding of the underlying early disease pathology, resulting in a critical gap in knowledge that limits patient treatment. Additionally, there are no specific biomarkers test to diagnose PD. The primary objective of our lab’s current work is to identify early stage (prodromal) gene biomarkers and pathways linked to vocalization and that are involved in the early stages of disease. Our lab models early-stage vocal motor behavioral deficits using a phosphatase and tensin homolog (PTEN)-induced putative kinase 1 knockout (Pink1-/-) rat as well as rat neuron cell culture. Opportunities in the lab for summer 2023 include: 1. Drug repurposing and cell culture. Previously generated RNA-sequencing datasets have identified enriched genetic pathways and differentially expressed genes that are dysregulated in the Pink1-/- rat model of PD and relate to vocal production. In vitro, drugs, already identified via computational drug repurposing, will be applied to Pink1-/- neuron cell cultures. Corresponding molecular assays will be performed (IF, WB, PCR). 2. Using stereotaxic coordinates to perform a site-specific injection into vocal motor nuclei in the rat brain. 3. Piloting the effects of a TNF-a blocker in the rat model of PD. | 0 | Primary researcher | Some | We are able to train extensively on basic laboratory skills. Animal handling may be required. | N/A | Yes | Yes | Yes | UW undergraduates interested in research | No | No | David Barnett (dbarnett@wisc.edu), Sarah Lechner (slechner@wisc.edu) | Cynthia Kelm-Nelson, cakelm@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuep-Rvx023ZUEgvNYTZVHskMvJD7r1DR5e2HTSJMcWq292SqAWr2rZGe7kFeZsrXlo | ||||||||
| jenett@medicine.wisc.edu | Jeniel | Nett | MD PhD | Associate Professor | 608 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Mechanisms of Candida auris skin colonization: Candida auris colonizes the skin of patients and spreads person-to-person in healthcare facilities. We found that C. auris proliferates in the skin environment and forms biofilms. This project is examining mechanisms of pathogenicity for C. auris skin colonization. A Shapiro student would grow wildtype and mutant C. auris biofilms and examine phenotypes. ____________________________________________________________________________ Role - This is a bench work opportunity.; IRB Status - N/A; Skills - None | Infectious Diseases | Medical Microbiology & Immunology | Mechanisms of Candida auris skin colonization | Candida auris colonizes the skin of patients and spreads person-to-person in healthcare facilities. We found that C. auris proliferates in the skin environment and forms biofilms. This project is examining mechanisms of pathogenicity for C. auris skin colonization. A Shapiro student would grow wildtype and mutant C. auris biofilms and examine phenotypes. | 1 | This is a bench work opportunity. | The student would be trained on experiments and could progress to independence as comfortable | None | N/A | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Unsure / Depends | N/A | Jeniel Nett, jenett@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucyw157gGA50CAWMtDIR9AY9oPX6lS7QiwM27gIj78H-ZPgEWWm_V-EjnlvztHiBTw | |||||||
| agepner@medicine.wisc.edu | Adam | Gepner | MD | Associate Professor of Medicine | 6.085.778.048 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Understanding blood pressure and hemodynamic assessments in older Veterans based on Hypertensive Status - FAST Vets Study.: The FAST-Vet study enrolled 180 Veterans over 60 years old with and without hypertension. Veterans underwent an arterial stress test where vascular parameters were measured before and after exercise (day 1) and sublingual nitroglycerin (day 2). Arterial stiffness and cardiovascular hemodynamics were obtained. We have several ongoing subaims that where a Shapiro Scholar could help test and analyze novel non-invasive diagnostics to personalize hypertension care in older adults. Our lab challenges the existing dogma that blood pressure are best measured at rest. Potential Specific Projects: 1. Evaluate differences between central and peripheral blood pressure with age and hypertension status. 2. Evaluate differences and similarities between arterial stiffness parameters following exercise or nitroglycerin administration based on hypertension status. A scholar could use these skills to non-invasively improve diagnosis, treatment goals, and quality of life in an older at-risk adults. Website: https://www.medicine.wisc.edu/cardiovascular-medicine/gepner-research ____________________________________________________________________________ Role - A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevent topics. 2. Review and understand FAST-Vet protocol and study techniques. 3. Review and analyze data on a subaims of the FAST-Vets study (see projects ideas above). 4. Compose a research proposal/abstract/manuscript; IRB Status - Active; Skills - Some statistical and programming background is helpful but not required. | Cardiovascular Medicine | Understanding blood pressure and hemodynamic assessments in older Veterans based on Hypertensive Status - FAST Vets Study. | The FAST-Vet study enrolled 180 Veterans over 60 years old with and without hypertension. Veterans underwent an arterial stress test where vascular parameters were measured before and after exercise (day 1) and sublingual nitroglycerin (day 2). Arterial stiffness and cardiovascular hemodynamics were obtained. We have several ongoing subaims that where a Shapiro Scholar could help test and analyze novel non-invasive diagnostics to personalize hypertension care in older adults. Our lab challenges the existing dogma that blood pressure are best measured at rest. Potential Specific Projects: 1. Evaluate differences between central and peripheral blood pressure with age and hypertension status. 2. Evaluate differences and similarities between arterial stiffness parameters following exercise or nitroglycerin administration based on hypertension status. A scholar could use these skills to non-invasively improve diagnosis, treatment goals, and quality of life in an older at-risk adults. Website: https://www.medicine.wisc.edu/cardiovascular-medicine/gepner-research | 0 | A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevent topics. 2. Review and understand FAST-Vet protocol and study techniques. 3. Review and analyze data on a subaims of the FAST-Vets study (see projects ideas above). 4. Compose a research proposal/abstract/manuscript | The scholar should be comfortable working independently and with our research team | Some statistical and programming background is helpful but not required. | Active | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | Amy Hein - Amy.Hein@va.gov | Adam Gepner, agepner@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufEkzqlo-47Fw2fu6G9kZFqKuaVT9YisF6f9TYn169ALH4pYZXCWB71EcRMGonrrLQ | ||||||||
| 02/08/2023 | hellenbrand@neurosurgery.wisc.edu | Amgad | Hanna | MD | Professor Neurological Surgery | Neurological Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Treating Spinal Cord Injury via Tailored Delivery of Anti-Inflammatory Cytokines: Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. Inflammatory cytokines are strongly upregulated during the first 24 hours after SCI, and there is a second wave of inflammatory cytokine expression around 14 days. Using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, however, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood-spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of anti-inflammatory cytokines, coinciding with critical stages of the ensuing inflammatory response, given directly in the injury site for at least 14 days. For this project, we are using a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI. ____________________________________________________________________________ Role - Performing hands on rat surgeries, rat care, and researching papers; IRB Status - N/A; Skills - There are no skills required. The student will need to take several safety and training courses to work in the lab. Most of these courses are just online, but rat handling and rat surgery need to be done in person through the RARC. If you are interested, we can discuss safety and training more in person. | Dan Hellenbrand, Researcher III | hellenbrand@neurosurgery.wisc.edu | Neurological Surgery | Treating Spinal Cord Injury via Tailored Delivery of Anti-Inflammatory Cytokines | Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. Inflammatory cytokines are strongly upregulated during the first 24 hours after SCI, and there is a second wave of inflammatory cytokine expression around 14 days. Using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, however, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood-spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of anti-inflammatory cytokines, coinciding with critical stages of the ensuing inflammatory response, given directly in the injury site for at least 14 days. For this project, we are using a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI. | 0 | Performing hands on rat surgeries, rat care, and researching papers | The student will usually work directly with Dan Hellenbrand and a team of students, but sometimes will be working independently. | There are no skills required. The student will need to take several safety and training courses to work in the lab. Most of these courses are just online, but rat handling and rat surgery need to be done in person through the RARC. If you are interested, we can discuss safety and training more in person. | N/A | Yes | Yes | Yes | Not currently available to mentor other students | Yes | No | N/A | Amgad Hanna, hellenbrand@neurosurgery.wisc.edu -- Co-Mentor: Dan Hellenbrand, Researcher III hellenbrand@neurosurgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuePkKiwuo28WPKSU1lO7AysWdJUV-AMgnjKXNJfMHf_7UkSZGDEfsnOVsmXkjwDZW8 | ||||||
| kschaumberg@wisc.edu | Katherine | Schaumberg | PhD | Assistant Professor | Psychiatry | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Adolescent Weight Trajectories and Eating Disorder Risk : The project will use clinical growth chart data along with indicators of eating disorder onset to define appropriate, individualized levels of weight restoration during eating disorder recovery. We will recruit a sample of youth in partial or full recovery from EDs to clarify whether weight restoration to premorbid weight status, as developmentally indicated, associates with other markers of eating disorder recovery and relapse both cross-sectionally and longitudinally. We will simultaneously develop a graphical tool for clinicians to clarify expected body weight across development, derived from growth chart data and age of eating disorder onset. For more information on the EMBARK Lab, see : embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Recruitment; Assessment of Adolescent Participants; Development of Clinician Tools; IRB management; IRB Status - Not Yet Submitted; Skills - Interest in working with adolescents; clinical interviewing | Adolescent Weight Trajectories and Eating Disorder Risk | The project will use clinical growth chart data along with indicators of eating disorder onset to define appropriate, individualized levels of weight restoration during eating disorder recovery. We will recruit a sample of youth in partial or full recovery from EDs to clarify whether weight restoration to premorbid weight status, as developmentally indicated, associates with other markers of eating disorder recovery and relapse both cross-sectionally and longitudinally. We will simultaneously develop a graphical tool for clinicians to clarify expected body weight across development, derived from growth chart data and age of eating disorder onset. For more information on the EMBARK Lab, see : embark.psychiatry.wisc.edu | 0 | Recruitment; Assessment of Adolescent Participants; Development of Clinician Tools; IRB management | Student will work as part of laboratory team | Interest in working with adolescents; clinical interviewing | Not Yet Submitted | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | Yes | Lauren Pictor; lpictor@wisc.edu; kayo Tada; kkern3@wisc.edu | Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueqvhtnwC8ih8-R6zYr1VTdc_dkmDQIzVodIeMzW9S2eVzHk-rHJ95rzA2FDYcSdsI | ||||||||||
| kschaumberg@wisc.edu | Katherine | Schaumberg | PhD | Assistant Professor | Psychiatry | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Multimodal Assessment of Exercise in Eating Disorders: This project evaluates exercise response among individuals with eating disorders to 1) characterize variability in biobehavioral response to in-lab exposure to moderate-intensity exercise among those with and without EDs; 2) create and refine tasks that capture engagement of reward- and threat-related systems during exercise. Our sample includes adolescent and young adult females (aged 14-22y) with a DSM-5 restrictive-spectrum ED diagnosis (AN; atypical AN; AN-spectrum OSFED), and age-matched healthy controls (HC). We examine multi-modal response (self-report state body image and affect, model-based learning, neurotransmitter shifts) to an acute bout of exercise using two novel exercise tasks, one in which participants are asked to drink a high-calorie beverage prior to exercise to trigger threat and capture threat-reduction mechanisms of exercise, and a second task primarily assessing the rewarding features of exercise. embark lab website: embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Clinical Recruitment; Phlebotomy; Assessment; IRB Status - Approved; Skills - Interest in working with adolescents | Multimodal Assessment of Exercise in Eating Disorders | This project evaluates exercise response among individuals with eating disorders to 1) characterize variability in biobehavioral response to in-lab exposure to moderate-intensity exercise among those with and without EDs; 2) create and refine tasks that capture engagement of reward- and threat-related systems during exercise. Our sample includes adolescent and young adult females (aged 14-22y) with a DSM-5 restrictive-spectrum ED diagnosis (AN; atypical AN; AN-spectrum OSFED), and age-matched healthy controls (HC). We examine multi-modal response (self-report state body image and affect, model-based learning, neurotransmitter shifts) to an acute bout of exercise using two novel exercise tasks, one in which participants are asked to drink a high-calorie beverage prior to exercise to trigger threat and capture threat-reduction mechanisms of exercise, and a second task primarily assessing the rewarding features of exercise. embark lab website: embark.psychiatry.wisc.edu | 0 | Clinical Recruitment; Phlebotomy; Assessment | Student will work as part of a laboratory team | Interest in working with adolescents | Approved | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | Lauren Pictor; lpictor@wisc.edu; kayo Tada: kkearn3@wisc.edu | Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufbDZMBRsT4lf1npMiCyvuVMWo6P5WSQ2X4tbjJXS2Aodi6w5ckimw9pJAIsQwY-mU | ||||||||||
| 12/01/2022 | mtlong@wisc.edu | Micah | Long | MD | Associate Professor | 920 | Anesthesiology | Research Electives for credit | Reversal of Paralysis in the Cardiothoracic Surgery Intensive Care Unit: Patients are given paralysis in the operating room to tolerate surgery. This is most often reversed in the operating room, but when patients undergo cardiac surgery, this is often skipped and left up to the discretion of the intensive care team. Unfortunately, due to false assumptions about drug offset, residual paralysis is a very real, potentially life threatening problem. We know reversal is often skipped and believe that this greatly impacts outcomes. While this has been shown repeatedly for regular OR cases, it has never been published in the CTICU. We plan to review all patients who underwent cardiac surgery, who received paralysis with rocuronium and who were extubated within 24-hours, comparing those who received reversal of paralysis, and those who did not, for important clinical outcomes, including mortality. ____________________________________________________________________________ Role - Coordinating the IT export of data, then guidance / statistical planning for study design for necessary outcome measures, then literature search and writing up of the effort. For multi-center effort, this will involve preparation of lectures/powerpoints and writeups, including potential local-grant funding requests.; IRB Status - Submitting, expected approval by end of 2022.; Skills - Medical students have more than enough skill for this | Critical Care | Medicine | Critical Care | John T. Dollerschell | dollerschell@wisc.edu | Anesthesiology | Critical Care & Cardiothoracic Anesthesiology | Reversal of Paralysis in the Cardiothoracic Surgery Intensive Care Unit | Patients are given paralysis in the operating room to tolerate surgery. This is most often reversed in the operating room, but when patients undergo cardiac surgery, this is often skipped and left up to the discretion of the intensive care team. Unfortunately, due to false assumptions about drug offset, residual paralysis is a very real, potentially life threatening problem. We know reversal is often skipped and believe that this greatly impacts outcomes. While this has been shown repeatedly for regular OR cases, it has never been published in the CTICU. We plan to review all patients who underwent cardiac surgery, who received paralysis with rocuronium and who were extubated within 24-hours, comparing those who received reversal of paralysis, and those who did not, for important clinical outcomes, including mortality. | 1 | Coordinating the IT export of data, then guidance / statistical planning for study design for necessary outcome measures, then literature search and writing up of the effort. For multi-center effort, this will involve preparation of lectures/powerpoints and writeups, including potential local-grant funding requests. | Independent for chart review and meetings with IT, with guidance from research mentors. | Medical students have more than enough skill for this | Submitting, expected approval by end of 2022. | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan, PhD; Kelly McQueen, MD; Joshua Sebranek, MD; Will Katz, MBA | Micah Long, mtlong@wisc.edu -- Co-Mentor: John T. Dollerschell dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucVe7QT1jgrYxGxzNYhi4uG4ebBmCrrg5a7D1Gp8CsA02T-wmMZhc4wCtI2ZFrZSBs | |
| 01/04/2023 | vtma@medicine.wisc.edu | Vincent | Ma | MD | Assistant Professor (CHS) | 6.082.635.391 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Evaluating clinical outcomes of metastatic melanoma and other advanced skin cancer patients treated with immunotherapy: This is a clinical research project focused on retrospectively reviewing all melanoma and non-melanoma skin cancer patients treated with immunotherapy at the University of Wisconsin. The goal of this project is to identify clinical variables that impact treatment response/resistance, survival outcomes, and development of treatment toxicities in this patient population. A database with over 250 melanoma patients has already been chart reviewed but requires further validation and cohort expansion. Using this database, we plan to conduct further statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports. Depending on the student’s level of motivation, students will have the opportunity to submit their abstracts for presentation at international conferences (SITC, ESMO, and/or ASCO). ____________________________________________________________________________ Role - Chart review; Analyze data; Work with a statistician; Write articles for publication and abstract presentations.; IRB Status - IRB Approved - UW21110; Skills - None. Experience with writing articles/manuscripts is highly desirable. Just be motivated, engaged, and be willing to work hard on clinical research. | Hematology, Medical Oncology, and Palliative Care | Dermatology | Evaluating clinical outcomes of metastatic melanoma and other advanced skin cancer patients treated with immunotherapy | This is a clinical research project focused on retrospectively reviewing all melanoma and non-melanoma skin cancer patients treated with immunotherapy at the University of Wisconsin. The goal of this project is to identify clinical variables that impact treatment response/resistance, survival outcomes, and development of treatment toxicities in this patient population. A database with over 250 melanoma patients has already been chart reviewed but requires further validation and cohort expansion. Using this database, we plan to conduct further statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports. Depending on the student’s level of motivation, students will have the opportunity to submit their abstracts for presentation at international conferences (SITC, ESMO, and/or ASCO). | 0 | Chart review; Analyze data; Work with a statistician; Write articles for publication and abstract presentations. | Students will require some training on data extraction from HealthLink (UW's electronic medical records system) and education on oncologic therapies, but will otherwise be independent with chart reviewing and data analysis on their own time and location. Hours are very flexible. Students will have the opportunity (if desired) to shadow me in the medical oncology clinic and attend research meetings. | None. Experience with writing articles/manuscripts is highly desirable. Just be motivated, engaged, and be willing to work hard on clinical research. | IRB Approved - UW21110 | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students | No | No | Laddie Johnson (lbj@medicine.wisc.edu); Renae Quale (rmq@medicine.wisc.edu) | Vincent Ma, vtma@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuefdhoTw7L2iCJCcJ6nMbSTVwg040uQDwzAGdFir4Nx7ByUCZFsRagGUsCeDW3ybyM | ||||||
| 11/07/2022 | mwharer@wisc.edu | Matthew | Harer | MD | Associate Professor of Pediatrics - Neonatologist | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Utilizing renal oxygenation monitoring with NIRS and evaluating urinary metabolomics to improve the diagnosis of neonatal acute kidney injury: This will include working on a project that has prospectively enrolled over 50 premature neonatal patients who have undergone renal oxygen monitoring and urinary sample collection for the first 14 days of life. The urine samples are being analyzed for metabolites and we will have robust results to interpret on the first 40 patients. We also will have renal oxygenation data and this will result in multiple potential projects to evaluate factors that affect kidney oxygenation. Please see previous publications from Dr. Harer on this topic and check out our research group link below: https://www.pediatrics.wisc.edu/research/research-groups/harer/ ____________________________________________________________________________ Role - This project will be a combination of multiple types of research and a specific project will be picked after meeting with prospective students: - Enrollment of prospective patients for a clinical research study in the NICU - Active participation in day-to-day research activities for a clinical study - Chart review for data abstraction - Evaluation of urinary metabolomic results - Evaluation of renal oxygenation Students will work closely with Dr. Harer, other Harer Research Group team members, and Pediatric Clinical Research Nurse Coordinators to learn skills necessary to complete a comprehensive research project project including but not limited to: - Hypothesis generating research question - Specific aim development - Data collection - Study enrollment - Ethics of research - Basic statistical techniques (including graphing on GraphPad Prism) - Abstract writing - Presentation/Poster development; IRB Status - Approved; Skills - None required, previous research experience is helpful. | Neonatology | Utilizing renal oxygenation monitoring with NIRS and evaluating urinary metabolomics to improve the diagnosis of neonatal acute kidney injury | This will include working on a project that has prospectively enrolled over 50 premature neonatal patients who have undergone renal oxygen monitoring and urinary sample collection for the first 14 days of life. The urine samples are being analyzed for metabolites and we will have robust results to interpret on the first 40 patients. We also will have renal oxygenation data and this will result in multiple potential projects to evaluate factors that affect kidney oxygenation. Please see previous publications from Dr. Harer on this topic and check out our research group link below: https://www.pediatrics.wisc.edu/research/research-groups/harer/ | 0 | This project will be a combination of multiple types of research and a specific project will be picked after meeting with prospective students: - Enrollment of prospective patients for a clinical research study in the NICU - Active participation in day-to-day research activities for a clinical study - Chart review for data abstraction - Evaluation of urinary metabolomic results - Evaluation of renal oxygenation Students will work closely with Dr. Harer, other Harer Research Group team members, and Pediatric Clinical Research Nurse Coordinators to learn skills necessary to complete a comprehensive research project project including but not limited to: - Hypothesis generating research question - Specific aim development - Data collection - Study enrollment - Ethics of research - Basic statistical techniques (including graphing on GraphPad Prism) - Abstract writing - Presentation/Poster development | Significant | None required, previous research experience is helpful. | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Becky Bound, Dept of Peds Research lead | Matthew Harer, mwharer@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudRpxGPwxaDS57Tz8EoUl8Qgeh5DghbYk3Qk4c2-MvB1FwHiib2VL2AP5TcQa8KZUQ | ||||||||
| lschnapp@medicine.wisc.edu | Lynn | Schnapp | MD | Professor, Chair of Medicine | 608 | Medicine | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity, Willing to work with interested students to develop an appropriate research experience | Mechanisms in lung injury, inflammation and repair: Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn ____________________________________________________________________________ Role - The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab.; IRB Status - n/a; Skills - Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | Pulmonary and Critical Care Medicine | Cell and Regenerative Biology | Carole Wilson, Research Associate Professor | cwilson@medicine.wisc.edu | Medicine | Pulmonary and Critical Care Medicine | Mechanisms in lung injury, inflammation and repair | Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn | 0 | The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab. | We can tailor the project to the student’s interests and aptitude. The student would work closely with lab personnel. | Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | n/a | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | 1. Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. Chest. 1;146(6):1543-53. 2014. PMC4251616 2. Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G. CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 308(8):L759-65. 2015 3. Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methe BA, Kaminski N, Sandhaus RA, GRADS Alpha-1 Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc. 12(10):1551-60. 2015. PMC4627425. *listed collaborator 4. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 12(10):1561-71 2015. PMID: 26193069. *listed collaborator 5. Gharib SA, Malur A, Huizar I, Barna BP, Kavuru MS, Schnapp LM*, Thomassen MJ*. Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 17(1):93. 2016 *Shared senior authorship. 6. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM*, Gharib SA*. Widespread activation of immunity and pro‐inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiological Reports. 4(8) pii: e12756. 2016. PMC4848721. *Shared senior authorship. 7. Attia EF, Jolley SE, Crothers K, Schnapp LM*, Liles WC*. Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS One. 11(2):e0149687. 2016 *Shared senior authorship. 8. Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM. Ablation of Pericyte-like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. Am J Respir Cell Mol Biol. 56(2):160-167 2017. PMC5359647. (Featured in “Red Alerts” highlighted articles) 9. Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA. Lung pericyte-like cells are functional immune sentinel cells. Am J Physiol Lung Cell Mol Physiol. 312(4): L556-L567. 2017. PMC5407093. (Chosen for “APSselect” highlight) 10. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Strange S, for QUANTUM-1 Investigators. Serum proteins associated with emphysema progression in severe alpha-1 antitrypsin deficiency. Chronic Obstr Pulm Dis. 4(3): 204-216. 2017 11. Mohan A, Malur A, McPeek M, Barna BP, Schnapp LM*, Thomassen MJ*, Gharib SA*. Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis. Am J Physiol Lung Cell Mol Physiol. 314(4):L617-L625, 2017. PMC5966779 *Shared senior authorship. 12. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV Infection on Alpha-1 Antitrypsin in the Lung. Am J Physiol Lung Cell Mol Physiol. 314(4):L583-L592. 2017. PMC5966776 13. Hung CF, Wilson CL, Chow YH, Schnapp LM. Role of integrin alpha8 in murine model of lung fibrosis. PLoS One. 13(5):e0197937. 2018. PMC5973593. 14. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 218(12):1995-2005, 2018. 15. Wilson CL, Stephenson SE, Higuero JP, Feghali-Bostwick C, Hung CF, Schnapp LM Characterization of human PDGFRβ-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18. doi: 10.1152/ajplung.00289.2018. PMID:30335500 16. Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group. The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. Am J Med Sci. 2019 May;357(5):405-410. PubMed PMID: 31010467. 17. Hung CF, Wilson CL, Schnapp LM. Pericytes in the Lung. Adv Exp Med Biol. 2019;1122:41-58. PubMed PMID: 30937862. 18. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest 2021. 19. Stephenson SE, Wilson CL, Bond NG, Kaur A, Alvarez X, Midkiff CC, Schnapp LM. Pericytes as novel targets for HIV/SIV infection in the lung. Am J Physiol Lung Cell Mol Physiol 2020; 319: L848-l853. 20. Mohan A, Neequaye N, Malur A, Soliman E, McPeek M, Leffler N, Ogburn D, Tokarz DA, Knudson W, Gharib SA, Schnapp LM, Barna BP, Thomassen MJ. Matrix Metalloproteinase-12 Is Required for Granuloma Progression. Front Immunol 2020; 11: 553949. | Yes | jewerndli@medicine.wisc.edu | Lynn Schnapp, lschnapp@medicine.wisc.edu -- Co-Mentor: Carole Wilson, Research Associate Professor cwilson@medicine.wisc.edu | ||||
| 11/06/2022 | ddshapiro@wisc.edu | Daniel | Shapiro | MD | Assistant Professor Urologic Oncology | Urology | Shorter term projects | Role of adjuvant therapy in localized renal cell carcinoma: Students will be investigating the role of adjuvant therapy in renal cell carcinoma. To do this, students will be identifying patients who have had complete resection of localized disease or oligometastatic disease and then identifying prognostic factors that are associated with recurrence or progression. My lab also is evaluating the tumor immune microenvironment for RCC, and how this impacts recurrence; thus, students have the opportunity to participate in clinical and translational projects. Other clinical projects are available involving renal cell carcinoma that can be chosen if the student is interested in another project. My goal is to provide a project to the student that will be able to be completed and result in abstracts for presentation at local and national meetings as well as publications. Students with some background statistical knowledge will be helpful, but not a requirement. Most importantly the student must be motivated. The student will learn about clinical and translational research, meet during weekly lab meetings, join in our multidisciplinary kidney cancer research group at least once per month, and have the opportunity to shadow in the clinic and the operating room. ____________________________________________________________________________ Role - Research Assistant; IRB Status - Approved; Skills - Excel, basic statistics is helpful | Role of adjuvant therapy in localized renal cell carcinoma | Students will be investigating the role of adjuvant therapy in renal cell carcinoma. To do this, students will be identifying patients who have had complete resection of localized disease or oligometastatic disease and then identifying prognostic factors that are associated with recurrence or progression. My lab also is evaluating the tumor immune microenvironment for RCC, and how this impacts recurrence; thus, students have the opportunity to participate in clinical and translational projects. Other clinical projects are available involving renal cell carcinoma that can be chosen if the student is interested in another project. My goal is to provide a project to the student that will be able to be completed and result in abstracts for presentation at local and national meetings as well as publications. Students with some background statistical knowledge will be helpful, but not a requirement. Most importantly the student must be motivated. The student will learn about clinical and translational research, meet during weekly lab meetings, join in our multidisciplinary kidney cancer research group at least once per month, and have the opportunity to shadow in the clinic and the operating room. | 1 | Research Assistant | Excel, basic statistics is helpful | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | roberts@urology.wisc.edu; mussehl@urology.wisc.edu | Daniel Shapiro, ddshapiro@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudDJ1yVKj80HyboDJfywJJdc7eR3siEv4MxuTbfp-ODK8UF7vkmKZoobiBhy3Ou3gw | ||||||||||
| huy.dinh@wisc.edu | Huy | Dinh | Ph.D. | Assistant Professor | 6.082.632.890 | Oncology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Bioinformatics analysis of Cancer & inflammation Data: Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early detection, progression, and treatment response in cancers and inflammation (e.g., burn injury). We work closely with UW Health clinicians from the Department of Medicine and Surgery. Thus, we will train prospective students to perform statistical and computational analyses to address biological/medical questions. They will work with graduate students and postdocs on current lab projects studying immunology in cancer and inflammation. Their analysis will be acknowledged by authorship in the lab's manuscripts. ____________________________________________________________________________ Role - Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project.; IRB Status - N/A; Skills - Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | Biostatistics and Medical Informatics | Bioinformatics analysis of Cancer & inflammation Data | Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early detection, progression, and treatment response in cancers and inflammation (e.g., burn injury). We work closely with UW Health clinicians from the Department of Medicine and Surgery. Thus, we will train prospective students to perform statistical and computational analyses to address biological/medical questions. They will work with graduate students and postdocs on current lab projects studying immunology in cancer and inflammation. Their analysis will be acknowledged by authorship in the lab's manuscripts. | 2 | Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project. | N/A | Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | N/A | No | No (plan to use Dean's Office Funds) | N/A | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | N/A | Huy Dinh, huy.dinh@wisc.edu -- Co-Mentor: | |||||||||
| 12/09/2022 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Chair | 0 | Neurological Surgery | Shorter term projects | Pathophysiology of stroke, atherosclerosis and brain tumor: The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. We are also focusing on identification of blood biomarkers associated with stroke risk and outcome. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. ____________________________________________________________________________ Role - Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field.; IRB Status - Approved; Skills - Some exposure to basic lab technique. However, we will train. | Umadevi Wesley PhD, Distinguished Scientist/Research Professor | wesley@neurosurgery.wisc.edu | Neurological Surgery | Pathophysiology of stroke, atherosclerosis and brain tumor | The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. We are also focusing on identification of blood biomarkers associated with stroke risk and outcome. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. | 0 | Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. | Somewhat - Fairly independent | Some exposure to basic lab technique. However, we will train. | Approved | Yes | Yes | Yes | PhD students | Yes | No | N/A | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Umadevi Wesley PhD, Distinguished Scientist/Research Professor wesley@neurosurgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufjaPGBiZcrL_NpP_0Pae5S0PvHb7M7h2oPaDBnk4BqNo6kyq8lKMiyBHeNigffjBI | |||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | MALDI-TOF MS vs Molecular Panel for Blood Cultures: Fairly straightforward data analysis and chart review project to determine the similarities, differences, and clinical impact between two rapid methods used to identify bacteria in blood cultures (MALDI-TOF mass spectrometry versus multiplex molecular panel testing). This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic chart review | MALDI-TOF MS vs Molecular Panel for Blood Cultures | Fairly straightforward data analysis and chart review project to determine the similarities, differences, and clinical impact between two rapid methods used to identify bacteria in blood cultures (MALDI-TOF mass spectrometry versus multiplex molecular panel testing). This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic chart review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueVQjHsdVNZ-3P4mAknMzVRJzsg4VtBI3zMlruNoMlo2qP0iq6P6eZRoKb0Io3wvDE | |||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | Utility of Legionella Cultures: Fairly straightforward data analysis and chart review project to determine the utility of Legionella cultures and comparison to the Legionella urinary antigen. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic chart review | Utility of Legionella Cultures | Fairly straightforward data analysis and chart review project to determine the utility of Legionella cultures and comparison to the Legionella urinary antigen. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic chart review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucl1XfcKecriLdL7QLu2gHBRoMDH0KykQcpeOoTeHhQ2SaPzMZlqzbbuKFFF2bnYOc | |||||||||
| 01/10/2023 | awalaszek@wisc.edu | Art | Walaszek | MD | Professor | 608 | Psychiatry | Not currently interested or available for Non-Shapiro research mentoring of medical students | Improving dementia care in Wisconsin through education: Our team at the Wisconsin Alzheimer’s Institute works to improve the care of people with BPSD by teaching healthcare providers better assessment and management of BPSD and helping train the next generation of healthcare professionals to better detect and treat dementia. Specifically, our next project will examine the impact of BPSD education on feasibility and sustainability of new clinical practices, and the effectiveness of the education and BPSD strategies in improving clinical outcomes for patients living with dementia and their caregivers. More info: https://wai.wisc.edu/improving-dementia-care-wi/ ____________________________________________________________________________ Role - The student could be involved in data acquisition, data analysis, presenting outcomes, and collaborating with our team.; IRB Status - We have IRB approval; Skills - An interest in improving the care of persons living with dementia, literature reviews, data collection, and writing skills | Medicine | Geriatric Medicine | Tammy LeCaire, MS, PhD | tjlecaire@wisc.edu | Wisconsin Alzheimer’s Institute | Improving dementia care in Wisconsin through education | Our team at the Wisconsin Alzheimer’s Institute works to improve the care of people with BPSD by teaching healthcare providers better assessment and management of BPSD and helping train the next generation of healthcare professionals to better detect and treat dementia. Specifically, our next project will examine the impact of BPSD education on feasibility and sustainability of new clinical practices, and the effectiveness of the education and BPSD strategies in improving clinical outcomes for patients living with dementia and their caregivers. More info: https://wai.wisc.edu/improving-dementia-care-wi/ | 0 | The student could be involved in data acquisition, data analysis, presenting outcomes, and collaborating with our team. | Moderate; guidance and direction will be provided by PI, co-mentor and program coordinator | An interest in improving the care of persons living with dementia, literature reviews, data collection, and writing skills | We have IRB approval | No | Yes | Yes | Not currently available to mentor other students | Yes | Yes | Molly Schroeder, mjschroeder3@wisc.edu; Sarah Klein, sarah.klein@wisc.edu | Art Walaszek, awalaszek@wisc.edu -- Co-Mentor: Tammy LeCaire, MS, PhD tjlecaire@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufwV5Hyw2wMjpkANTabH5rIXRMt6WVdgpnmhM9d_1YlMgx-2wPpmF9jYq7yKwSeJ1g | |||
| 12/10/2022 | PLang@ortho.wisc.edu | Pamela | Lang | MD | Associate Professor | 6.082.656.516 | Orthopedics and Rehabilitation | Shorter term projects, Research Electives for credit | Pediatric Youth Knee Injury Registry Study: UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2023 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. ____________________________________________________________________________ Role - The student will be responsible for 1) Identifying, recruiting and enrolling participants. 2) Contacting participants who have not responded to specific inquiries, 3) Assist staff with scoring, editing and analyzing data we collect for this study, 4) Assist bio-mechanic faculty to segment MRIs of patella instability patients so the staff we can create a model to complement with the clinical and cadaver studies, 5) Work effectively and collaboratively with other team members. ; IRB Status - HS-IRB 2019-0028 - Approved; Skills - 1) Able to effectively interact with potential participants and their parents in clinc settings. 2) Edit and clean data in MS Excel spreadsheets and REDCap3) Work effectively and collaboratively with other team members. | Sports Medicine | Timothy McGuine | mcguine@ortho.wisc.edu | Orthopedics and Rehabilitation | Sports Medicine | Pediatric Youth Knee Injury Registry Study | UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2023 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. | 0 | The student will be responsible for 1) Identifying, recruiting and enrolling participants. 2) Contacting participants who have not responded to specific inquiries, 3) Assist staff with scoring, editing and analyzing data we collect for this study, 4) Assist bio-mechanic faculty to segment MRIs of patella instability patients so the staff we can create a model to complement with the clinical and cadaver studies, 5) Work effectively and collaboratively with other team members. | Moderate | 1) Able to effectively interact with potential participants and their parents in clinc settings. 2) Edit and clean data in MS Excel spreadsheets and REDCap3) Work effectively and collaboratively with other team members. | HS-IRB 2019-0028 - Approved | No | Yes | Yes | DPT students, MPH students | No | No | Josh Roth (Roth@ortho.wisc.edu) Heidi Abledinger (Ableidinger@ortho.wisc.edu) | Pamela Lang, PLang@ortho.wisc.edu -- Co-Mentor: Timothy McGuine mcguine@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucZngxhNCnt2BWc5un7WsZL-u_zPk34GC13G1J4nTXhcYBK9z0youoLU6i8sGNguoY | |||
| dshirley@medicine.wisc.edu | Dan | Shirley | MD, MS | Assistant Professor | Medicine | Shorter term projects | Developing and Implementing Quality improvement projects to improve Infection Prevention at King Faisal Hospital (KFH), Kigali Rwanda: We have performed a qualitative analysis of infection control practices at King Faisal Hospital in Kigali, Rwanda using the Systems Engineering Initiative for Patient Safety (SIEPS) model. Based on that we like to develop a quality improvement project based on King Faisal Hospital priorities. Potential areas include hand hygiene/promotion of standard precautions or development/implementation of invasive device audits. ____________________________________________________________________________ Role - Data collection, data analysis, manuscript preparation; IRB Status - In progress; Skills - familiarity with qualitative research collection or analysis would be helpful | Infectious Disease | Dawd Siraj, MD, MPH&TM, Professor | dssiraj@medicine.wisc.edu | Medicine | Infectious Diseases | Developing and Implementing Quality improvement projects to improve Infection Prevention at King Faisal Hospital (KFH), Kigali Rwanda | We have performed a qualitative analysis of infection control practices at King Faisal Hospital in Kigali, Rwanda using the Systems Engineering Initiative for Patient Safety (SIEPS) model. Based on that we like to develop a quality improvement project based on King Faisal Hospital priorities. Potential areas include hand hygiene/promotion of standard precautions or development/implementation of invasive device audits. | 0 | Data collection, data analysis, manuscript preparation | Moderate to high (mentors are available for research; independent travel to Rwanda) | familiarity with qualitative research collection or analysis would be helpful | In progress | No | No (plan to use Dean's Office Funds) | Yes | MPH students | No | Yes | acmapes@medicine.wisc.edu | Dan Shirley, dshirley@medicine.wisc.edu -- Co-Mentor: Dawd Siraj, MD, MPH&TM, Professor dssiraj@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuds4P0OoCkAINng4B0iszagV_Qu0AvhjDw7hU3rLjwYMYCTe88x9uHWnY46GWqeYLI | |||||
| dssiraj@medicine.wisc.edu | Dawd | Siraj | MD, MPH&TM | Professor | Medicine | Shorter term projects | Bacterial culture, Antimicrobial Resistance and the implementation of Antibiogram at King Faisal Hospital (KFH) in Kigali, Rwanda: This will be followup study to our Shapiro project from last year. We have done retrospective data collection of organisms responsible for bacterial infections at King Faisal Hospital (KFH) in Kigali, Rwanda. Now we want to determine susceptibility patterns, and estimate the likelihood of successful treatment of these organisms based on empiric antibiotic use for different types of infection. We will also like to continue this study creating an antibiograms for clinical use and implement education and tools for dissemination of this to frontline healthcare providers; begin organization of a multidisciplinary antimicrobial stewardship team with the aim of optimizing antibiotics use in the hospital. This project requires travel to Kigali, Rwanda for about two weeks to collect data. ____________________________________________________________________________ Role - Data collection, data analysis, manuscript preparation; IRB Status - In progress; Skills - attention to detail for data collection | Infectious Disease | Dan Shirley, MD, MS, Assistant Professor | dshirley@medicine.wisc.edu | Medicine | Infectious Disease | Bacterial culture, Antimicrobial Resistance and the implementation of Antibiogram at King Faisal Hospital (KFH) in Kigali, Rwanda | This will be followup study to our Shapiro project from last year. We have done retrospective data collection of organisms responsible for bacterial infections at King Faisal Hospital (KFH) in Kigali, Rwanda. Now we want to determine susceptibility patterns, and estimate the likelihood of successful treatment of these organisms based on empiric antibiotic use for different types of infection. We will also like to continue this study creating an antibiograms for clinical use and implement education and tools for dissemination of this to frontline healthcare providers; begin organization of a multidisciplinary antimicrobial stewardship team with the aim of optimizing antibiotics use in the hospital. This project requires travel to Kigali, Rwanda for about two weeks to collect data. | 1 | Data collection, data analysis, manuscript preparation | Moderate to high (mentors are available for research; independent travel to Rwanda) | attention to detail for data collection | In progress | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Yes | acmapes@medicine.wisc.edu | Dawd Siraj, dssiraj@medicine.wisc.edu -- Co-Mentor: Dan Shirley, MD, MS, Assistant Professor dshirley@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuc2w41oqkbxWRVLQ-12djO9CntcwjeMdP71_Jeiq-s2lq2ig3CIE1ekbz7B479lwpw | |||||
| mralbert@wisc.edu | Mark | Albertini | MD | Professor | 608 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma: Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. Lab web site: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research ____________________________________________________________________________ Role - The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin. ; IRB Status - N/A; Skills - Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | Hematology/Medical Oncology/Palliative Care | Cindy Zuleger, PhD | clz@medicine.wisc.edu | Medicine | Hematology/Medical Oncology/Palliative Care | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma | Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. Lab web site: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research | 0 | The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin. | Ability to independently review the literature related to the research project is required. While mentoring is provided in the lab, progressing to independence with laboratory analyses is expected. | Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | N/A | VA Merit Grant | Plan to apply to the Dept of Medicine for stipend support or use the Dean's Office Funds. I do not have separate funding to cover 50% of the Shapiro summer student's stipend. | Yes | PhD students, UW undergraduates interested in research | No | No | Dr. Cindy Zuleger: clz@medicine.wisc.edu | Mark Albertini, mralbert@wisc.edu -- Co-Mentor: Cindy Zuleger, PhD clz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudVfqoyjvw8EQQ6CQN45M_iXwY3moBMj6NMX6dMUGyIVpjqGqeCAzLiAlkBrjl1FXQ | ||||
| mralbert@wisc.edu | Mark | Albertini | M.D. | Professor | 608 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PIG-A mutant T-cells as a biomarker of response to immune checkpoint blockade in metastatic melanoma: Melanoma-reactive T-cells are lymphocytes that have been stimulated in vivo by tumor antigens to undergo cell division. As mutation is expected to occur preferentially in dividing cells, a clonal assay that selects for T-cells with a specific in vivo mutation could enrich for T-cells that have undergone repetitive in vivo cell division. The Albertini lab has studied selection of T-cells with mutation acquired in vivo in a reporter gene (the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene) by in vivo harvesting of lymphocytes followed by clonal expansion in vitro in the presence of 6-thioguanine. Findings in melanoma patients demonstrate an increase in HPRT mutant frequency (MF) compared to normal controls. Despite the virtues of the HPRT mutation system, there are several deficiencies. Namely it is time consuming, expensive, and need for in vitro expansion. The phosphatidylinositol glycan class A (PIG-A) gene is one of four genes that code for the proteins constituting glucosamine acetyl (GlcNAc) transferase – a multimeric enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. PIG-A is located on the X-chromosome and therefore is hemizygous. Mutation in PIG-A gene results in a deficiency of surface expressions of all GPI-anchored proteins. A cloning assay for PIG-A mutant T-lymphocytes has been described, and it allows isolation of mutants for molecular and functional analyses without extensive cytokine-mediated growth in vitro and the manual scoring methods currently required for determination of HPRT mutant frequencies by cloning. The objective of this project is to validate and implement a rapid, fluorescence-activated cell sorter (FACS) based assay to quantitatively assess frequencies of somatic mutant T-cells (PIG-A mutants) in melanoma patients in vivo. Lab website: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research ____________________________________________________________________________ Role - The student will directly participate in the laboratory studies. The student will be trained in flow cytometry, sterile cell culture, and molecular assessment of T-cell receptor gene usage. In addition to the laboratory duties, the student will have involvement with melanoma patients on translational melanoma research studies ; IRB Status - This project is approved by the IRB.; Skills - Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | Hematology/Medical Oncology/Palliative Care | Cindy Zuleger | clz@medicine.wisc.edu | Medicine | Hematology/Medical Oncology/Palliative Care | PIG-A mutant T-cells as a biomarker of response to immune checkpoint blockade in metastatic melanoma | Melanoma-reactive T-cells are lymphocytes that have been stimulated in vivo by tumor antigens to undergo cell division. As mutation is expected to occur preferentially in dividing cells, a clonal assay that selects for T-cells with a specific in vivo mutation could enrich for T-cells that have undergone repetitive in vivo cell division. The Albertini lab has studied selection of T-cells with mutation acquired in vivo in a reporter gene (the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene) by in vivo harvesting of lymphocytes followed by clonal expansion in vitro in the presence of 6-thioguanine. Findings in melanoma patients demonstrate an increase in HPRT mutant frequency (MF) compared to normal controls. Despite the virtues of the HPRT mutation system, there are several deficiencies. Namely it is time consuming, expensive, and need for in vitro expansion. The phosphatidylinositol glycan class A (PIG-A) gene is one of four genes that code for the proteins constituting glucosamine acetyl (GlcNAc) transferase – a multimeric enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. PIG-A is located on the X-chromosome and therefore is hemizygous. Mutation in PIG-A gene results in a deficiency of surface expressions of all GPI-anchored proteins. A cloning assay for PIG-A mutant T-lymphocytes has been described, and it allows isolation of mutants for molecular and functional analyses without extensive cytokine-mediated growth in vitro and the manual scoring methods currently required for determination of HPRT mutant frequencies by cloning. The objective of this project is to validate and implement a rapid, fluorescence-activated cell sorter (FACS) based assay to quantitatively assess frequencies of somatic mutant T-cells (PIG-A mutants) in melanoma patients in vivo. Lab website: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research | 0 | The student will directly participate in the laboratory studies. The student will be trained in flow cytometry, sterile cell culture, and molecular assessment of T-cell receptor gene usage. In addition to the laboratory duties, the student will have involvement with melanoma patients on translational melanoma research studies | Ability to independently review the literature related to the research project is required. While mentoring is provided in the lab, progressing to independence with laboratory analyses is expected. | Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | This project is approved by the IRB. | VA Merit Grant and and a gift from Ann's Hope Foundation | Plan to apply to the Dept of Medicine for stipend support or use the Dean's Office Funds. I do not have separate funding to cover 50% of the Shapiro summer student's stipend. | Yes | PhD students, UW undergraduates interested in research | No | No | Dr. Cindy Zuleger: clz@medicine.wisc.edu | Mark Albertini, mralbert@wisc.edu -- Co-Mentor: Cindy Zuleger clz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf4qujWALSnBKR-F0H-ZU0oAnZXdrRRSoDA4jpDjnQPMy5pdGnCePyo22aPf6yt_6o | ||||
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Non-Shapiro Opportunities | Project Information | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | blank 1 | Mentor Information | Response |