Please note that ALL projects with open slots are available to Shapiro applicants. “Non-Shapiro Opportunities” refer to opportunities available for medical students interested in a shorter term (non-summer) projects and yearlong projects.
Summer Research 2023
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Non-Shapiro Opportunities | Project Information | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | blank 1 | Mentor Information | Response |
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| 11/04/2022 | epetty@wisc.edu | Elizabeth | Petty | MD | Professor, Senior Associate Dean | 608 | Pediatrics | Shorter term projects | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning: The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - N/A; Skills - Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | Pediatrics - Genetics and Metabolism | Other | Academic Affairs - Dean's Office Administration | Sherryl Pertzborn, MBA | Other | Academic Affairs - Dean's Office Administration | Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning | The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. | 2 | Depends on student’s interests | Students will meet with mentors formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily avaiable. | Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | N/A | Yes | Yes | Yes | Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Unsure / Depends | Unsure / Depends | N/A | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: Sherryl Pertzborn, MBA | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufZw3OS9lCS7uri7zJAoaBdCeyU06-llc-3Rw64OPmTORz5oAJGP_ALFJ4YOx8Lo1A | ||
| 11/06/2022 | ddshapiro@wisc.edu | Daniel | Shapiro | MD | Assistant Professor Urologic Oncology | Urology | Shorter term projects | Role of adjuvant therapy in localized renal cell carcinoma: Students will be investigating the role of adjuvant therapy in renal cell carcinoma. To do this, students will be identifying patients who have had complete resection of localized disease or oligometastatic disease and then identifying prognostic factors that are associated with recurrence or progression. My lab also is evaluating the tumor immune microenvironment for RCC, and how this impacts recurrence; thus, students have the opportunity to participate in clinical and translational projects. Other clinical projects are available involving renal cell carcinoma that can be chosen if the student is interested in another project. My goal is to provide a project to the student that will be able to be completed and result in abstracts for presentation at local and national meetings as well as publications. Students with some background statistical knowledge will be helpful, but not a requirement. Most importantly the student must be motivated. The student will learn about clinical and translational research, meet during weekly lab meetings, join in our multidisciplinary kidney cancer research group at least once per month, and have the opportunity to shadow in the clinic and the operating room. ____________________________________________________________________________ Role - Research Assistant; IRB Status - Approved; Skills - Excel, basic statistics is helpful | Role of adjuvant therapy in localized renal cell carcinoma | Students will be investigating the role of adjuvant therapy in renal cell carcinoma. To do this, students will be identifying patients who have had complete resection of localized disease or oligometastatic disease and then identifying prognostic factors that are associated with recurrence or progression. My lab also is evaluating the tumor immune microenvironment for RCC, and how this impacts recurrence; thus, students have the opportunity to participate in clinical and translational projects. Other clinical projects are available involving renal cell carcinoma that can be chosen if the student is interested in another project. My goal is to provide a project to the student that will be able to be completed and result in abstracts for presentation at local and national meetings as well as publications. Students with some background statistical knowledge will be helpful, but not a requirement. Most importantly the student must be motivated. The student will learn about clinical and translational research, meet during weekly lab meetings, join in our multidisciplinary kidney cancer research group at least once per month, and have the opportunity to shadow in the clinic and the operating room. | 1 | Research Assistant | Excel, basic statistics is helpful | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | roberts@urology.wisc.edu; mussehl@urology.wisc.edu | Daniel Shapiro, ddshapiro@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudDJ1yVKj80HyboDJfywJJdc7eR3siEv4MxuTbfp-ODK8UF7vkmKZoobiBhy3Ou3gw | ||||||||||
| 11/07/2022 | mwharer@wisc.edu | Matthew | Harer | MD | Associate Professor of Pediatrics - Neonatologist | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Utilizing renal oxygenation monitoring with NIRS and evaluating urinary metabolomics to improve the diagnosis of neonatal acute kidney injury: This will include working on a project that has prospectively enrolled over 50 premature neonatal patients who have undergone renal oxygen monitoring and urinary sample collection for the first 14 days of life. The urine samples are being analyzed for metabolites and we will have robust results to interpret on the first 40 patients. We also will have renal oxygenation data and this will result in multiple potential projects to evaluate factors that affect kidney oxygenation. Please see previous publications from Dr. Harer on this topic and check out our research group link below: https://www.pediatrics.wisc.edu/research/research-groups/harer/ ____________________________________________________________________________ Role - This project will be a combination of multiple types of research and a specific project will be picked after meeting with prospective students: - Enrollment of prospective patients for a clinical research study in the NICU - Active participation in day-to-day research activities for a clinical study - Chart review for data abstraction - Evaluation of urinary metabolomic results - Evaluation of renal oxygenation Students will work closely with Dr. Harer, other Harer Research Group team members, and Pediatric Clinical Research Nurse Coordinators to learn skills necessary to complete a comprehensive research project project including but not limited to: - Hypothesis generating research question - Specific aim development - Data collection - Study enrollment - Ethics of research - Basic statistical techniques (including graphing on GraphPad Prism) - Abstract writing - Presentation/Poster development; IRB Status - Approved; Skills - None required, previous research experience is helpful. | Neonatology | Utilizing renal oxygenation monitoring with NIRS and evaluating urinary metabolomics to improve the diagnosis of neonatal acute kidney injury | This will include working on a project that has prospectively enrolled over 50 premature neonatal patients who have undergone renal oxygen monitoring and urinary sample collection for the first 14 days of life. The urine samples are being analyzed for metabolites and we will have robust results to interpret on the first 40 patients. We also will have renal oxygenation data and this will result in multiple potential projects to evaluate factors that affect kidney oxygenation. Please see previous publications from Dr. Harer on this topic and check out our research group link below: https://www.pediatrics.wisc.edu/research/research-groups/harer/ | 2 | This project will be a combination of multiple types of research and a specific project will be picked after meeting with prospective students: - Enrollment of prospective patients for a clinical research study in the NICU - Active participation in day-to-day research activities for a clinical study - Chart review for data abstraction - Evaluation of urinary metabolomic results - Evaluation of renal oxygenation Students will work closely with Dr. Harer, other Harer Research Group team members, and Pediatric Clinical Research Nurse Coordinators to learn skills necessary to complete a comprehensive research project project including but not limited to: - Hypothesis generating research question - Specific aim development - Data collection - Study enrollment - Ethics of research - Basic statistical techniques (including graphing on GraphPad Prism) - Abstract writing - Presentation/Poster development | Significant | None required, previous research experience is helpful. | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Becky Bound, Dept of Peds Research lead | Matthew Harer, mwharer@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudRpxGPwxaDS57Tz8EoUl8Qgeh5DghbYk3Qk4c2-MvB1FwHiib2VL2AP5TcQa8KZUQ | ||||||||
| 01/04/2023 | vtma@medicine.wisc.edu | Vincent | Ma | MD | Assistant Professor (CHS) | 6.082.635.391 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Evaluating clinical outcomes of metastatic melanoma and other advanced skin cancer patients treated with immunotherapy: This is a clinical research project focused on retrospectively reviewing all melanoma and non-melanoma skin cancer patients treated with immunotherapy at the University of Wisconsin. The goal of this project is to identify clinical variables that impact treatment response/resistance, survival outcomes, and development of treatment toxicities in this patient population. A database with over 250 melanoma patients has already been chart reviewed but requires further validation and cohort expansion. Using this database, we plan to conduct further statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports. Depending on the student’s level of motivation, students will have the opportunity to submit their abstracts for presentation at international conferences (SITC, ESMO, and/or ASCO). ____________________________________________________________________________ Role - Chart review; Analyze data; Work with a statistician; Write articles for publication and abstract presentations.; IRB Status - IRB Approved - UW21110; Skills - None. Experience with writing articles/manuscripts is highly desirable. Just be motivated, engaged, and be willing to work hard on clinical research. | Hematology, Medical Oncology, and Palliative Care | Dermatology | Evaluating clinical outcomes of metastatic melanoma and other advanced skin cancer patients treated with immunotherapy | This is a clinical research project focused on retrospectively reviewing all melanoma and non-melanoma skin cancer patients treated with immunotherapy at the University of Wisconsin. The goal of this project is to identify clinical variables that impact treatment response/resistance, survival outcomes, and development of treatment toxicities in this patient population. A database with over 250 melanoma patients has already been chart reviewed but requires further validation and cohort expansion. Using this database, we plan to conduct further statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports. Depending on the student’s level of motivation, students will have the opportunity to submit their abstracts for presentation at international conferences (SITC, ESMO, and/or ASCO). | 0 | Chart review; Analyze data; Work with a statistician; Write articles for publication and abstract presentations. | Students will require some training on data extraction from HealthLink (UW's electronic medical records system) and education on oncologic therapies, but will otherwise be independent with chart reviewing and data analysis on their own time and location. Hours are very flexible. Students will have the opportunity (if desired) to shadow me in the medical oncology clinic and attend research meetings. | None. Experience with writing articles/manuscripts is highly desirable. Just be motivated, engaged, and be willing to work hard on clinical research. | IRB Approved - UW21110 | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students | No | No | Laddie Johnson (lbj@medicine.wisc.edu); Renae Quale (rmq@medicine.wisc.edu) | Vincent Ma, vtma@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuefdhoTw7L2iCJCcJ6nMbSTVwg040uQDwzAGdFir4Nx7ByUCZFsRagGUsCeDW3ybyM | ||||||
| 11/10/2022 | mpuricelli@wisc.edu | Mike | Puricelli | MD | Assistant Professor | Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Epidemiology and airway interventions for potential airway obstruction: a Healthcare Cost and Utilization Project KID analysis: “Helping Babies Breathe” With advanced diagnosis of conditions that predispose neonates to airway obstruction at birth, delivery modifications can support more rapid onset of treatment or permit intervention on the fetus’s airway what oxygen and carbon dioxide exchange occur through the placenta. This potentially life-saving and function preserving treatment for the neonate requires a balance of neonatal beneficence, maternal non-maleficence, and just distribution of scarce resources. Due to the rarity of these interventions, there are few systematic data and a survey of fetal treatment centers shows high variation in selection criteria as well as cases of over or under allocation. The Puricelli Research Group is gathering data on the frequency and type of intervention required immediately following birth according to diagnosis to help guide selection and co-leading a collaboration with colleagues in other specialties to pool findings and support better predication of treatment needs. This will empower pregnant persons to make more informed treatment decisions. Example of 2022 Fellow's Work (multiple podium presentations and to be submitted for publication) "Background: Fetal goiter is a rare congenital disorder that can present with life-threatening neonatal airway obstruction. Lifesaving and function-preserving airway management strategies are available, but routine delivery presents a limited window for intervention. Accordingly, fetal goiter is among the most common indications for ex-utero intrapartum treatment (EXIT). While EXIT prolongs the window for airway intervention to benefit the neonate, it elevates the risk to the mother and requires extensive resources; therefore, data to guide ideal treatment selection are essential. Objectives: The objective of this study is to compare the necessity and type of perinatal airway interventions between the general population and individuals with fetal goiter. Methods: Birth hospitalizations among individuals with and without fetal goiter were identified in the Healthcare Cost and Utilization Project (HCUP) Kids’ Inpatient Database from 2000 to 2012. The frequency of airway interventions on day of life 0 or 1 and complications were compared between the groups using the Rao-Scott chi-square test. Additionally, birthweight, length of stay, and charges were examined for the goiter cohort. Results: One hundred sixty-six weighed cases of fetal goiter were identified in the study period. The population was 60% male, median birthweight 3.3 kg, median length of stay 3.4 days, and average total charges was $42,332. Airway intervention on neonatal day of life 0 or 1 was required in 15.1% of individuals with fetal goiter compared to 1.74% in neonates without fetal goiter (p <0.001). Required airway interventions were endotracheal intubation in 14.4% of cases and laryngoscopy/bronchoscopy in 4.23% of cases. No patients required a surgical airway, extracorporeal membrane oxygenation cannulation or cardiopulmonary resuscitation. There were no cases of perinatal airway attributable hypoxic encephalopathy. 83.02% of fetal goiter patients underwent routine discharge, while 9.63% underwent transfer to a short-term hospital. The remaining patients were transferred to a lower acuity care facility (4.27%) or home health care (3.08%). Conclusion: Individuals with fetal goiter require significantly higher rates of perinatal airway intervention, however, endoscopic interventions alone were sufficient to avoid neurologic complications of airway obstruction. This data supports more precise risk-benefit assessment for pregnant individuals and selection of values-based treatment." We completed a survey of fetal treatment centers and identified additional diagnoses that potentially warrant intervention. The methodology would be repeated for one or more of these conditions during the 2023 fellowship: Diagnoses for EXIT Consultation Response # (%) Consideration for EXIT Consultation Response # (%) Craniofacial skeletal condition 33/40 (82.5) Micrognathia 29/32 (90.6) Dysgnathia/otocephaly/synotia/agnathia 27/32 (84.4) Head and Neck Mass 40/40 (100) Teratoma (including epignathus) 39/40 (97.5) Lymphovascular malformation 38/40 (95) Thyroid mass/goiter 26/40 (65) Thymic cyst/mass 20/40 (50) Branchial cleft cyst 12/40 (30) Hamartoma/choristoma 12/40 (30) Lipoma 8/40 (20) Laryngocele 16/40 (40) Neuroblastoma 14/40 (35) Congenital High Airway Obstruction 36/40 (90) Laryngeal pathology including atresia, stenosis, web or cyst 35/36 (97.2) Tracheal pathology including atresia, stenosis, complete rings 33/36 (91.7) Bronchial pathology including atresia 15/36 (41.7) Iatrogenic (tracheal balloon occlusion) 26/40 (65) Congenital Diaphragmatic Hernia 5/40 (12.5) Thoracic/mediastinal mass 28/40 (70) Congenital cystic adenomatoid malformation/Pulmonary Malformation 14/21 (66.7) Bronchopulmonary sequestration 11/21 (52.4) Teratoma/lymphatic malformation 19/21 (90.5) Bronchogenic or enteric duplication cyst 9/21 (42.9) Pericardial mass 13/21 (61.9) Congenital heart disease 7/40 (17.5) Separation of conjoined twins 7/40 (17.5) Sacrococcygeal teratoma 17/40 (42.5) ____________________________________________________________________________ Role - Contribute to a search strategy and identify ICD 9 and 10 codes for the diagnoses above. Draft abstract/manuscript for the topic selected. The fellow(s) would be expected to contribute to other projects as time permits and join the mentor in the clinic and OR setting to obtain experience in the field of otolaryngology head and neck surgery. “Supporting Hearing and Ear Function” Early detection, diagnosis, and intervention for neonatal hearing loss results in improved long-term outcomes. Accordingly, state programs such as the Wisconsin Sound Beginnings program track and support these efforts. The Puricelli Research Group is engaged in efforts to expedite hearing screening and diagnostic testing to support earlier identification and avoid the need for patient exposure to sedation or general anesthesia. In addition, pediatric patients are shown to have lower ear reconstruction success than adults. Children with larger perforations or conditions that predispose to poor Eustachian tube opening are further at risk for worse outcomes. The Puricelli Research Group is examining large datasets to assess the impact of Complex Pediatric Ear, Nose and Throat conditions on surgical success with future plans to study advanced surgical techniques in an attempt to improve outcomes in this population. “Safer Head and Neck Surgery for Children with Spinal Anomalies” Obstructive sleep apnea is common in pediatric patients with complex medical conditions and multiple procedures/advanced sleep surgery is frequently required. For pediatric patients at risk of spinal cord compression, significant injury can result. An advanced monitoring technique has become standard in treatment of patients with scoliosis and shows promise to improve safety during sleep surgery in certain patient populations. The Puricelli Research Group is studying the frequency of spinal decompression surgery after head and neck operations to understand the need for this technology and has begun using it in practice. “Mitigating the Risk of Common Household Items” Accidents and injuries are among the most common causes of presentation to healthcare providers and a leading cause of death in children. The Consumer Product Safety Commission’s National Electronic Injury Surveillance System (NEISS) tracks injuries. The head and neck is a common site for injury and as consumer trends change, examination of data for differential risk is important to public health. Environmentally focused changes in consumer behavior are common including reduction in disposable plastics. The Puricelli Research Group is investigating how reusable items such as drinking straws affect patterns or oral and oropharyngeal trauma. “Innovation and Device Development” Dr. Puricelli is the co-recipient of a Wallace H. Coulter Foundation grant to develop a new surgical instrument used for minimally invasive as well as traditional eardrum reconstruction as well as a UI Ventures Technology Enhancement Grant to improve airway foreign body removal capacity and endoscopic laser delivery. The Puricelli Research Group developed a novel testing model to examine the benefits and limitations of current airway surgical energy delivery systems.; IRB Status - Not necessary; Skills - None | Otolaryngology - Head and Neck Surgery | Epidemiology and airway interventions for potential airway obstruction: a Healthcare Cost and Utilization Project KID analysis | “Helping Babies Breathe” With advanced diagnosis of conditions that predispose neonates to airway obstruction at birth, delivery modifications can support more rapid onset of treatment or permit intervention on the fetus’s airway what oxygen and carbon dioxide exchange occur through the placenta. This potentially life-saving and function preserving treatment for the neonate requires a balance of neonatal beneficence, maternal non-maleficence, and just distribution of scarce resources. Due to the rarity of these interventions, there are few systematic data and a survey of fetal treatment centers shows high variation in selection criteria as well as cases of over or under allocation. The Puricelli Research Group is gathering data on the frequency and type of intervention required immediately following birth according to diagnosis to help guide selection and co-leading a collaboration with colleagues in other specialties to pool findings and support better predication of treatment needs. This will empower pregnant persons to make more informed treatment decisions. Example of 2022 Fellow's Work (multiple podium presentations and to be submitted for publication) "Background: Fetal goiter is a rare congenital disorder that can present with life-threatening neonatal airway obstruction. Lifesaving and function-preserving airway management strategies are available, but routine delivery presents a limited window for intervention. Accordingly, fetal goiter is among the most common indications for ex-utero intrapartum treatment (EXIT). While EXIT prolongs the window for airway intervention to benefit the neonate, it elevates the risk to the mother and requires extensive resources; therefore, data to guide ideal treatment selection are essential. Objectives: The objective of this study is to compare the necessity and type of perinatal airway interventions between the general population and individuals with fetal goiter. Methods: Birth hospitalizations among individuals with and without fetal goiter were identified in the Healthcare Cost and Utilization Project (HCUP) Kids’ Inpatient Database from 2000 to 2012. The frequency of airway interventions on day of life 0 or 1 and complications were compared between the groups using the Rao-Scott chi-square test. Additionally, birthweight, length of stay, and charges were examined for the goiter cohort. Results: One hundred sixty-six weighed cases of fetal goiter were identified in the study period. The population was 60% male, median birthweight 3.3 kg, median length of stay 3.4 days, and average total charges was $42,332. Airway intervention on neonatal day of life 0 or 1 was required in 15.1% of individuals with fetal goiter compared to 1.74% in neonates without fetal goiter (p <0.001). Required airway interventions were endotracheal intubation in 14.4% of cases and laryngoscopy/bronchoscopy in 4.23% of cases. No patients required a surgical airway, extracorporeal membrane oxygenation cannulation or cardiopulmonary resuscitation. There were no cases of perinatal airway attributable hypoxic encephalopathy. 83.02% of fetal goiter patients underwent routine discharge, while 9.63% underwent transfer to a short-term hospital. The remaining patients were transferred to a lower acuity care facility (4.27%) or home health care (3.08%). Conclusion: Individuals with fetal goiter require significantly higher rates of perinatal airway intervention, however, endoscopic interventions alone were sufficient to avoid neurologic complications of airway obstruction. This data supports more precise risk-benefit assessment for pregnant individuals and selection of values-based treatment." We completed a survey of fetal treatment centers and identified additional diagnoses that potentially warrant intervention. The methodology would be repeated for one or more of these conditions during the 2023 fellowship: Diagnoses for EXIT Consultation Response # (%) Consideration for EXIT Consultation Response # (%) Craniofacial skeletal condition 33/40 (82.5) Micrognathia 29/32 (90.6) Dysgnathia/otocephaly/synotia/agnathia 27/32 (84.4) Head and Neck Mass 40/40 (100) Teratoma (including epignathus) 39/40 (97.5) Lymphovascular malformation 38/40 (95) Thyroid mass/goiter 26/40 (65) Thymic cyst/mass 20/40 (50) Branchial cleft cyst 12/40 (30) Hamartoma/choristoma 12/40 (30) Lipoma 8/40 (20) Laryngocele 16/40 (40) Neuroblastoma 14/40 (35) Congenital High Airway Obstruction 36/40 (90) Laryngeal pathology including atresia, stenosis, web or cyst 35/36 (97.2) Tracheal pathology including atresia, stenosis, complete rings 33/36 (91.7) Bronchial pathology including atresia 15/36 (41.7) Iatrogenic (tracheal balloon occlusion) 26/40 (65) Congenital Diaphragmatic Hernia 5/40 (12.5) Thoracic/mediastinal mass 28/40 (70) Congenital cystic adenomatoid malformation/Pulmonary Malformation 14/21 (66.7) Bronchopulmonary sequestration 11/21 (52.4) Teratoma/lymphatic malformation 19/21 (90.5) Bronchogenic or enteric duplication cyst 9/21 (42.9) Pericardial mass 13/21 (61.9) Congenital heart disease 7/40 (17.5) Separation of conjoined twins 7/40 (17.5) Sacrococcygeal teratoma 17/40 (42.5) | 2 | Contribute to a search strategy and identify ICD 9 and 10 codes for the diagnoses above. Draft abstract/manuscript for the topic selected. The fellow(s) would be expected to contribute to other projects as time permits and join the mentor in the clinic and OR setting to obtain experience in the field of otolaryngology head and neck surgery. “Supporting Hearing and Ear Function” Early detection, diagnosis, and intervention for neonatal hearing loss results in improved long-term outcomes. Accordingly, state programs such as the Wisconsin Sound Beginnings program track and support these efforts. The Puricelli Research Group is engaged in efforts to expedite hearing screening and diagnostic testing to support earlier identification and avoid the need for patient exposure to sedation or general anesthesia. In addition, pediatric patients are shown to have lower ear reconstruction success than adults. Children with larger perforations or conditions that predispose to poor Eustachian tube opening are further at risk for worse outcomes. The Puricelli Research Group is examining large datasets to assess the impact of Complex Pediatric Ear, Nose and Throat conditions on surgical success with future plans to study advanced surgical techniques in an attempt to improve outcomes in this population. “Safer Head and Neck Surgery for Children with Spinal Anomalies” Obstructive sleep apnea is common in pediatric patients with complex medical conditions and multiple procedures/advanced sleep surgery is frequently required. For pediatric patients at risk of spinal cord compression, significant injury can result. An advanced monitoring technique has become standard in treatment of patients with scoliosis and shows promise to improve safety during sleep surgery in certain patient populations. The Puricelli Research Group is studying the frequency of spinal decompression surgery after head and neck operations to understand the need for this technology and has begun using it in practice. “Mitigating the Risk of Common Household Items” Accidents and injuries are among the most common causes of presentation to healthcare providers and a leading cause of death in children. The Consumer Product Safety Commission’s National Electronic Injury Surveillance System (NEISS) tracks injuries. The head and neck is a common site for injury and as consumer trends change, examination of data for differential risk is important to public health. Environmentally focused changes in consumer behavior are common including reduction in disposable plastics. The Puricelli Research Group is investigating how reusable items such as drinking straws affect patterns or oral and oropharyngeal trauma. “Innovation and Device Development” Dr. Puricelli is the co-recipient of a Wallace H. Coulter Foundation grant to develop a new surgical instrument used for minimally invasive as well as traditional eardrum reconstruction as well as a UI Ventures Technology Enhancement Grant to improve airway foreign body removal capacity and endoscopic laser delivery. The Puricelli Research Group developed a novel testing model to examine the benefits and limitations of current airway surgical energy delivery systems. | None | Not necessary | No | Yes | Yes | MPH students, PhD students | No | Yes | Dr. Sandra Lin (Otolaryngology Chair) slin362@wisc.edu Ms. Jill Trulson (Administrative assistant) jtrulson@wisc.edu | Mike Puricelli, mpuricelli@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuczzL95hHeG63ot5czNZn6AwxtWV7bvnZRJyAeosSJZlTJuvJIK5a4l31lF3TJUrM4 | |||||||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Creating a Classification System for Abductor Musculature Atrophy and Abductor Tendon Tears: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone surgery for abductor tendon tears. We will then carefully classify their abductor tendons on magnetic resonance imaging, and base our newly described classification off of the Goutallier/Fuchs Rotator Cuff Classification. We will be able to look at patient reported outcomes after surgical fixation of these torn tendons, and will describe a way in which we can reliably describe tendon tears as well as fatty infiltration. This will be a project done in conjunction with our MSK radiology department in addition to the orthopaedic surgery department. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip preservation including abductor tendon repair) to have a more complete understanding of the importance of this study. The following papers represent similar studies: Bogunovic L, Lee SX, Haro MS, Frank JM, Mather RC 3rd, Bush-Joseph CA, Nho SJ. Application of the Goutallier/Fuchs Rotator Cuff Classification to the Evaluation of Hip Abductor Tendon Tears and the Clinical Correlation With Outcome After Repair. Arthroscopy. 2015 Nov;31(11):2145-51. doi: 10.1016/j.arthro.2015.04.101. Epub 2015 Jul 15. PMID: 26188781. Ishikura H, Nakamura M, Oka H, Yonezawa K, Hidaka R, Tanaka T, Kawano H, Tanaka S. A new classification system for evaluating fatty infiltration of the gluteus minimus in hip osteoarthritis using plain computed tomography. J Orthop Sci. 2022 Jul;27(4):792-797. doi: 10.1016/j.jos.2021.04.005. Epub 2021 May 24. PMID: 34039520. Looney AM, Bodendorfer BM, Donaldson ST, Browning RB, Chahla JA, Nho SJ. Influence of Fatty Infiltration on Hip Abductor Repair Outcomes: A Systematic Review and Meta-analysis. Am J Sports Med. 2022 Jul;50(9):2568-2580. doi: 10.1177/03635465211027911. Epub 2021 Sep 8. PMID: 34495797. Matthew Quinn, James Levins, Mohammadali Mojarrad, Ryan O’Donnell, Steven DeFroda, Erin Haggerty, Peter Evangelista, Ramin Tabaddor, Association of tensor fascia lata hypertrophy and fatty infiltration in the presence of abductor tendon tears: a radiographic study, Journal of Hip Preservation Surgery, Volume 8, Issue 2, July 2021, Pages 197–201, https://doi.org/10.1093/jhps/hnab058 Zacharias A, Pizzari T, English DJ, Kapakoulakis T, Green RA. Hip abductor muscle volume in hip osteoarthritis and matched controls. Osteoarthritis Cartilage. 2016 Oct;24(10):1727-1735. doi: 10.1016/j.joca.2016.05.002. Epub 2016 May 7. PMID: 27163446. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - : IRB approval for our registry and for this project under the IRB umbrella protocol; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Dr. Donna Blankenbaker | dblankenbaker@uwhealth.org | Radiology | Muskuloskeletal radiology | Creating a Classification System for Abductor Musculature Atrophy and Abductor Tendon Tears | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone surgery for abductor tendon tears. We will then carefully classify their abductor tendons on magnetic resonance imaging, and base our newly described classification off of the Goutallier/Fuchs Rotator Cuff Classification. We will be able to look at patient reported outcomes after surgical fixation of these torn tendons, and will describe a way in which we can reliably describe tendon tears as well as fatty infiltration. This will be a project done in conjunction with our MSK radiology department in addition to the orthopaedic surgery department. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip preservation including abductor tendon repair) to have a more complete understanding of the importance of this study. The following papers represent similar studies: Bogunovic L, Lee SX, Haro MS, Frank JM, Mather RC 3rd, Bush-Joseph CA, Nho SJ. Application of the Goutallier/Fuchs Rotator Cuff Classification to the Evaluation of Hip Abductor Tendon Tears and the Clinical Correlation With Outcome After Repair. Arthroscopy. 2015 Nov;31(11):2145-51. doi: 10.1016/j.arthro.2015.04.101. Epub 2015 Jul 15. PMID: 26188781. Ishikura H, Nakamura M, Oka H, Yonezawa K, Hidaka R, Tanaka T, Kawano H, Tanaka S. A new classification system for evaluating fatty infiltration of the gluteus minimus in hip osteoarthritis using plain computed tomography. J Orthop Sci. 2022 Jul;27(4):792-797. doi: 10.1016/j.jos.2021.04.005. Epub 2021 May 24. PMID: 34039520. Looney AM, Bodendorfer BM, Donaldson ST, Browning RB, Chahla JA, Nho SJ. Influence of Fatty Infiltration on Hip Abductor Repair Outcomes: A Systematic Review and Meta-analysis. Am J Sports Med. 2022 Jul;50(9):2568-2580. doi: 10.1177/03635465211027911. Epub 2021 Sep 8. PMID: 34495797. Matthew Quinn, James Levins, Mohammadali Mojarrad, Ryan O’Donnell, Steven DeFroda, Erin Haggerty, Peter Evangelista, Ramin Tabaddor, Association of tensor fascia lata hypertrophy and fatty infiltration in the presence of abductor tendon tears: a radiographic study, Journal of Hip Preservation Surgery, Volume 8, Issue 2, July 2021, Pages 197–201, https://doi.org/10.1093/jhps/hnab058 Zacharias A, Pizzari T, English DJ, Kapakoulakis T, Green RA. Hip abductor muscle volume in hip osteoarthritis and matched controls. Osteoarthritis Cartilage. 2016 Oct;24(10):1727-1735. doi: 10.1016/j.joca.2016.05.002. Epub 2016 May 7. PMID: 27163446. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI (Dr. Spiker) to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | : IRB approval for our registry and for this project under the IRB umbrella protocol | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | Unsure / Depends | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Dr. Donna Blankenbaker dblankenbaker@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucFyWGUihmBieKNwY9UeNqkMditS81e_2VeqBnRqXos66xXZiR_2CIROfOOAXtV-Lw | ||||
| spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Describing a Radiographic parameter of anterior and posterior wall intersection with the sorcil and correlation with diagnosis and outcomes: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. Radiographs for these patients will be reviewed, and measurements of the lateral center edge angle will be made using the currently accepted and described method. We will then re-measure the lateral center edge angle focusing on a new ‘end point’ which focuses on where the anterior wall of the acetabulum meets the sorcil and where the posterior wall of the acetabulum meets the sorcil. We will then determine a ratio between these three measurements, defining this for the first time, and correlate it with the diagnosis the patient was ultimately given (FAIS, borderline dysplasia or dysplasia), and the surgery the patient underwent (hip arthroscopy, hip arthroscopy plus PAO or PAO alone), and then we will review the patient reported outcomes to determine how the ratios of the various center edge angles correlate to diagnosis, treatment and outcomes. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our registry and for this project under the IRB umbrella protocol; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Describing a Radiographic parameter of anterior and posterior wall intersection with the sorcil and correlation with diagnosis and outcomes | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. Radiographs for these patients will be reviewed, and measurements of the lateral center edge angle will be made using the currently accepted and described method. We will then re-measure the lateral center edge angle focusing on a new ‘end point’ which focuses on where the anterior wall of the acetabulum meets the sorcil and where the posterior wall of the acetabulum meets the sorcil. We will then determine a ratio between these three measurements, defining this for the first time, and correlate it with the diagnosis the patient was ultimately given (FAIS, borderline dysplasia or dysplasia), and the surgery the patient underwent (hip arthroscopy, hip arthroscopy plus PAO or PAO alone), and then we will review the patient reported outcomes to determine how the ratios of the various center edge angles correlate to diagnosis, treatment and outcomes. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry and for this project under the IRB umbrella protocol | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | Unsure / Depends | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnud4QvhrgxILopayD2tSYZxIqAQBI9u4pj9OHwsgSmjUp7S5RDzI7PnF1rJuNbDqdLA | ||||||||
| apeterson@pediatrics.wisc.edu | Amy | Peterson | MD, MS | Associate Professor of Pedatrics | 6.082.625.024 | Pediatrics | Shorter term projects | Dyslipidemia patterns among children presenting to a pediatric preventive cardiology clinic: The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. Over the past eleven years our team has evaluated children with both genetic and environmental causes of dyslipidemia. During this time there has been an increase in cholesterol screening during childhood, which has increased diagnostic rates of severe dyslipidemia. Our team has never systematically evaluated the patterns of dyslipidemia that children have when they present to our clinic. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/peterson/ ____________________________________________________________________________ Role - Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired.; IRB Status - Student will be involved in IRB submission which will take place Jan-April 2023; Skills - None | Pediatric Cardiology | Dyslipidemia patterns among children presenting to a pediatric preventive cardiology clinic | The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. Over the past eleven years our team has evaluated children with both genetic and environmental causes of dyslipidemia. During this time there has been an increase in cholesterol screening during childhood, which has increased diagnostic rates of severe dyslipidemia. Our team has never systematically evaluated the patterns of dyslipidemia that children have when they present to our clinic. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/peterson/ | 0 | Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired. | This project requires a self-motivated learner and strong work ethic, but the research team will provide support for this project. | None | Student will be involved in IRB submission which will take place Jan-April 2023 | Yes | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, MPH students | No | Yes | Xiao Zhang, xiao.zhang@wisc.edu | Amy Peterson, apeterson@pediatrics.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufLQPLr4cGOWccLwxK-W9mPp46nrtqIu72ApfdNMRx2OzNhW_uXctZ8bZTtr7_1gPo | ||||||||
| calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | 6.084.179.953 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Analyzing the impact of a clinical practice guideline on central line choice and PICC line duration in pediatric patients: In November 2022, American Family Children's Hospital adopted a formal clinical practice guideline one choice of central line type for pediatric patients. This guideline is intended to be a tool for pediatric providers to help determine the most appropriate central line type based on indications and expected duration. This project will have three primary aims: 1) determine if there has been a change in types of central lines placed on patients at AFCH before and after the publication of this clinical practice guideline; 2) determine if the duration of PICC lines at AFCH has changed after the publication of this guideline; 3) determine if there have been any major shifts in who is placing central lines at AFCH. ____________________________________________________________________________ Role - chart review, data analysis, project write-up for presentation/publication; IRB Status - not yet submitted, will be IRB exempt as QI work (very brief application process); Skills - chart review, basic statistics, willingness to work with biostatistician to understand data | Pediatric Hematology/Oncology | Analyzing the impact of a clinical practice guideline on central line choice and PICC line duration in pediatric patients | In November 2022, American Family Children's Hospital adopted a formal clinical practice guideline one choice of central line type for pediatric patients. This guideline is intended to be a tool for pediatric providers to help determine the most appropriate central line type based on indications and expected duration. This project will have three primary aims: 1) determine if there has been a change in types of central lines placed on patients at AFCH before and after the publication of this clinical practice guideline; 2) determine if the duration of PICC lines at AFCH has changed after the publication of this guideline; 3) determine if there have been any major shifts in who is placing central lines at AFCH. | 1 | chart review, data analysis, project write-up for presentation/publication | guidance based on what the student requires/requests | chart review, basic statistics, willingness to work with biostatistician to understand data | not yet submitted, will be IRB exempt as QI work (very brief application process) | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Department of pediatrics administrators, I think Kim Stevenson (kdstevenson@pediatrics.wisc.edu) | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuceBY_yyUMp-GA5q27sOEwd6evBPijnFCS7ZbhjPL-4JtIt77tZLSq-GmrMV5-Ksfc | ||||||||
| calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | 6.084.179.953 | Pediatrics | Not currently interested or available for Non-Shapiro research mentoring of medical students | Written documentation compliance during maintenance for pediatric patients with acute lymphoblastic leukemia (ALL): Pediatric patients who are being treated for oncologic diagnoses all have a paper chart kept in the research offices at AFCH. It is standard practice to document blood counts and dose adjustments for oral chemotherapy on patient roadmaps in these paper charts but compliance with these standards is sub-optimal. We are creating a system to improve rates of proper documentation on the paper charts. This project would focus on chart review to determine documentation compliance before and after a division-wide intervention to emphasize importance of documenting dose adjustments in maintenance. ____________________________________________________________________________ Role - chart review, data analysis, first author responsibilities of creating a presentation/manuscript as a final product; IRB Status - not yet submitted, will be IRB exempt as QI work; Skills - chart review, basic statistics | Pediatric Hematology/Oncology | Written documentation compliance during maintenance for pediatric patients with acute lymphoblastic leukemia (ALL) | Pediatric patients who are being treated for oncologic diagnoses all have a paper chart kept in the research offices at AFCH. It is standard practice to document blood counts and dose adjustments for oral chemotherapy on patient roadmaps in these paper charts but compliance with these standards is sub-optimal. We are creating a system to improve rates of proper documentation on the paper charts. This project would focus on chart review to determine documentation compliance before and after a division-wide intervention to emphasize importance of documenting dose adjustments in maintenance. | 1 | chart review, data analysis, first author responsibilities of creating a presentation/manuscript as a final product | per the needs of the student | chart review, basic statistics | not yet submitted, will be IRB exempt as QI work | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Kim Stevenson kdstevenson@pediatrics.wisc.edu | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudMoJ4j_zPmVXHJhyNkIo15WdeHpqb2gwEJUuCTiJMy3Y3cE2f0KIb2Vl5Ecb4lsBs | ||||||||
| sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Associate professor | 6.082.650.152 | Medicine | Shorter term projects, on going various other projects | Risk factors and outcomes of post transplant erythrocytosis (PTE) among simultaneous pancreas and kidney (SPK) transplant recipients : To evaluate risk factors and outcomes of PTE in SPK ____________________________________________________________________________ Role - student will serve as a lead in this project with goal to publish from our data base. May need minimal chart review. Will be involved in literature search, preparation of abstract and ultimately full manuscript. In 2020 - Beyann Alzoubi ( current M4, through Shapiro project) (DOI: 10.1111/ctr.14166) has published similar studies among kidney only transplant recipients, now in this project, we would like to expland research among SPK recipients ; IRB Status - Will be approved soon, ; Skills - Minimal, will guide as needed. Need energy and enthusiasm | Nephrology - Transplant | Risk factors and outcomes of post transplant erythrocytosis (PTE) among simultaneous pancreas and kidney (SPK) transplant recipients | To evaluate risk factors and outcomes of PTE in SPK | 1 | student will serve as a lead in this project with goal to publish from our data base. May need minimal chart review. Will be involved in literature search, preparation of abstract and ultimately full manuscript. In 2020 - Beyann Alzoubi ( current M4, through Shapiro project) (DOI: 10.1111/ctr.14166) has published similar studies among kidney only transplant recipients, now in this project, we would like to expland research among SPK recipients | Minimal, will guide as needed. Need energy and enthusiasm | Will be approved soon, | No | No (plan to use Dean's Office Funds) | Have been mentoring medical students for more than 6 years and have published more than 15 papers with medical students as a first author | Not currently available to mentor other students | No | No | N/A | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf1bOgRkkbTu7yci33W-IIXqKeLHQJ1wh4VwpZaZ8ZYVP7enKSX8Y2rzIg-hJFAVyU | |||||||||
| sparajuli@medicine.wisc.edu | sandesh | parajuli | MD | Associate professor | 6.082.650.152 | Medicine | Shorter term projects, Research Electives for credit | Does serum albumin levels at time of hospital admission among kidney transplant recipients with COVID-19 infection predict poor outcomes : Among kidney transplant recipients, pre-transplant serum albumin level has been associated with poor post transplant outcomes in our own studies, conducted by our medical students doi: 10.1016/j.ekir.2020.09.012. ; doi: 10.1111/ctr.14862 we reported poor outcomes associated with serum albumin level. In general population with covid, doi: 10.1002/jmv.26003; DOI: 10.1016/j.medcli.2020.12.018)- also serum ablumin level at time of hospital admission is marker of poor outcomes. Howeve,r it is not known the association of serum albumin level and outcomes among kidney transplant recipients with COVID. ____________________________________________________________________________ Role - Will serve as a lead for the project, will work with group, conduct literature search, analyze data, prepare abstract and ultimately manuscript. ; IRB Status - Will be approved soon ; Skills - None/minimal- will mentor. Need energy and enthusiasm | Nephrology-transplant | Does serum albumin levels at time of hospital admission among kidney transplant recipients with COVID-19 infection predict poor outcomes | Among kidney transplant recipients, pre-transplant serum albumin level has been associated with poor post transplant outcomes in our own studies, conducted by our medical students doi: 10.1016/j.ekir.2020.09.012. ; doi: 10.1111/ctr.14862 we reported poor outcomes associated with serum albumin level. In general population with covid, doi: 10.1002/jmv.26003; DOI: 10.1016/j.medcli.2020.12.018)- also serum ablumin level at time of hospital admission is marker of poor outcomes. Howeve,r it is not known the association of serum albumin level and outcomes among kidney transplant recipients with COVID. | 1 | Will serve as a lead for the project, will work with group, conduct literature search, analyze data, prepare abstract and ultimately manuscript. | None/minimal- will mentor. Need energy and enthusiasm | Will be approved soon | No | No (plan to use Dean's Office Funds) | Have been mentoring multiple medical students since 2017, and have published with students more than 15 papers. | Not currently available to mentor other students | No | No | N/A | sandesh parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucqg9Q7GD8esRTxwgzDDTEiRFjkV1xogjE-2mPjvuS1lL1mukrHytbcPxBl16HfGSk | |||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | 608 | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | Meningitis/Encephalitis Pathogen Panel Utility: Fairly straightforward chart review project to determine the utility of the Meningitis/Encephalitis Pathogen panel. The student will be involved from the very beginning of the project. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data Collection and Analysis; IRB Status - N/A; Skills - Excel, Epic Chart Review | Meningitis/Encephalitis Pathogen Panel Utility | Fairly straightforward chart review project to determine the utility of the Meningitis/Encephalitis Pathogen panel. The student will be involved from the very beginning of the project. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data Collection and Analysis | Any | Excel, Epic Chart Review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucqeQep9AEkIRpKHd_O0CjixD1UqcbUqvPcVUO7YRNIMc90aYJ15qA2hlckNMnP3hw | ||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | Optimal incubation duration for prosthetic joint cultures: Fairly straightforward chart review project to determine the utility of the extending incubation of prosthetic joint tissue cultures to 14 days. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic Chart Review | Optimal incubation duration for prosthetic joint cultures | Fairly straightforward chart review project to determine the utility of the extending incubation of prosthetic joint tissue cultures to 14 days. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, analysis, abstract writing | Any | Excel, Epic Chart Review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucOjlZFW2xyEGcdL5_r0XSBX7ME9DoV1JqiBJBv5YNdti47AM_5xdg8v1m4bvunMaw | |||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | False Positive Gonorrhea and Chlamydia Results: Fairly straightforward data collection and chart review project to determine the extent of false positive gonorrhea and chlamydia results based on molecular testing. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic chart review | False Positive Gonorrhea and Chlamydia Results | Fairly straightforward data collection and chart review project to determine the extent of false positive gonorrhea and chlamydia results based on molecular testing. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic chart review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueV3B0A9Dl5SawzBx8vhid54Fsu1sQIdo8FmZ_ACFbCMhCfGobnvs6ChRQOPWhF-8c | |||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | MALDI-TOF MS vs Molecular Panel for Blood Cultures: Fairly straightforward data analysis and chart review project to determine the similarities, differences, and clinical impact between two rapid methods used to identify bacteria in blood cultures (MALDI-TOF mass spectrometry versus multiplex molecular panel testing). This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic chart review | MALDI-TOF MS vs Molecular Panel for Blood Cultures | Fairly straightforward data analysis and chart review project to determine the similarities, differences, and clinical impact between two rapid methods used to identify bacteria in blood cultures (MALDI-TOF mass spectrometry versus multiplex molecular panel testing). This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic chart review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueVQjHsdVNZ-3P4mAknMzVRJzsg4VtBI3zMlruNoMlo2qP0iq6P6eZRoKb0Io3wvDE | |||||||||
| 12/01/2022 | dchen@uwhealth.org | Derrick | Chen | MD | Medical Director of Clinical Microbiology | Pathology and Laboratory Medicine | Shorter term projects, Research Electives for credit | Utility of Legionella Cultures: Fairly straightforward data analysis and chart review project to determine the utility of Legionella cultures and comparison to the Legionella urinary antigen. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. ____________________________________________________________________________ Role - Data collection, data analysis, abstract writing; IRB Status - N/A; Skills - Excel, Epic chart review | Utility of Legionella Cultures | Fairly straightforward data analysis and chart review project to determine the utility of Legionella cultures and comparison to the Legionella urinary antigen. This project has a high chance of having an abstract accepted at a national conference. Depending on the results, there could be potential for a manuscript publication. | 1 | Data collection, data analysis, abstract writing | Any | Excel, Epic chart review | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | dchen@uwhealth.org | Derrick Chen, dchen@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucl1XfcKecriLdL7QLu2gHBRoMDH0KykQcpeOoTeHhQ2SaPzMZlqzbbuKFFF2bnYOc | |||||||||
| 12/01/2022 | mtlong@wisc.edu | Micah | Long | MD | Associate Professor | 920 | Anesthesiology | Research Electives for credit | Reversal of Paralysis in the Cardiothoracic Surgery Intensive Care Unit: Patients are given paralysis in the operating room to tolerate surgery. This is most often reversed in the operating room, but when patients undergo cardiac surgery, this is often skipped and left up to the discretion of the intensive care team. Unfortunately, due to false assumptions about drug offset, residual paralysis is a very real, potentially life threatening problem. We know reversal is often skipped and believe that this greatly impacts outcomes. While this has been shown repeatedly for regular OR cases, it has never been published in the CTICU. We plan to review all patients who underwent cardiac surgery, who received paralysis with rocuronium and who were extubated within 24-hours, comparing those who received reversal of paralysis, and those who did not, for important clinical outcomes, including mortality. Once done at UW, we hope to group an already-arranged multicenter cohort to publish a 2nd broad, high-impact trial. ____________________________________________________________________________ Role - Coordinating the IT export of data, then guidance / statistical planning for study design for necessary outcome measures, then literature search and writing up of the effort. For multi-center effort, this will involve preparation of lectures/powerpoints and writeups, including potential local-grant funding requests.; IRB Status - Submitting, expected approval by end of 2022.; Skills - Medical students have more than enough skill for this | Critical Care | Emergency Medicine | Critical Care | John T. Dollerschell | dollerschell@wisc.edu | Anesthesiology | Critical Care & Cardiothoracic Anesthesiology | Reversal of Paralysis in the Cardiothoracic Surgery Intensive Care Unit | Patients are given paralysis in the operating room to tolerate surgery. This is most often reversed in the operating room, but when patients undergo cardiac surgery, this is often skipped and left up to the discretion of the intensive care team. Unfortunately, due to false assumptions about drug offset, residual paralysis is a very real, potentially life threatening problem. We know reversal is often skipped and believe that this greatly impacts outcomes. While this has been shown repeatedly for regular OR cases, it has never been published in the CTICU. We plan to review all patients who underwent cardiac surgery, who received paralysis with rocuronium and who were extubated within 24-hours, comparing those who received reversal of paralysis, and those who did not, for important clinical outcomes, including mortality. Once done at UW, we hope to group an already-arranged multicenter cohort to publish a 2nd broad, high-impact trial. | 1 | Coordinating the IT export of data, then guidance / statistical planning for study design for necessary outcome measures, then literature search and writing up of the effort. For multi-center effort, this will involve preparation of lectures/powerpoints and writeups, including potential local-grant funding requests. | Independent for chart review and meetings with IT, with guidance from research mentors. | Medical students have more than enough skill for this | Submitting, expected approval by end of 2022. | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan, PhD; Kelly McQueen, MD; Joshua Sebranek, MD; Will Katz, MBA | Micah Long, mtlong@wisc.edu -- Co-Mentor: John T. Dollerschell dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucVe7QT1jgrYxGxzNYhi4uG4ebBmCrrg5a7D1Gp8CsA02T-wmMZhc4wCtI2ZFrZSBs | |
| 12/01/2022 | lhanks@wisc.edu | Laura | Hanks | MD | PI | Obstetrics & Gynecology | Shorter term projects | Female surgical sterilization rates before and after the Dobbs decision: On June 24, 2022 the Supreme Court issued a decision on the Dobbs v. Jackson Women's Health Organization by a 6-3 vote, that the Constitution of the United States does not confer a right to abortion. This decision overruled both Roe v. Wade (1973) and Planned Parenthood v. Case (1992). The Dobbs decision gave individual states the full power to regulate any aspect of abortion not protected by feral law. In the state of Wisconsin the issue of abortion was first addressed in 1849, when lawmakers enacted a general prohibition on abortion after quickening (the mother's perception of fetal movement), providing an exception for the life of the mother. From 1973 until the Dobbs ruling, this statute was unenforceable due to Roe and subsequent rulings, however this law was reinstated after the Dobbs decision, making all abortions illegal unless preformed for the life of the mother. For many women in Wisconsin, this was perceived as an attack on their bodily autonomy. We, as obstetrician-gynecologists, heard their stories and saw a large influx of women requesting sterilization due to fear of being forced to carry an unplanned and undesired pregnancy to term. Our research aims to evaluate sterilizations performed at Meriter hospital for the year prior to the Dobbs decision and the year after. It will be a retrospective chart review. ____________________________________________________________________________ Role - Reviewing charts of female patients who underwent surgical sterilization at Meriter over the past 2 years; IRB Status - Will likely be exempted but submitting now; Skills - Epic compentency, HIPPA compliant | ASOG | Female surgical sterilization rates before and after the Dobbs decision | On June 24, 2022 the Supreme Court issued a decision on the Dobbs v. Jackson Women's Health Organization by a 6-3 vote, that the Constitution of the United States does not confer a right to abortion. This decision overruled both Roe v. Wade (1973) and Planned Parenthood v. Case (1992). The Dobbs decision gave individual states the full power to regulate any aspect of abortion not protected by feral law. In the state of Wisconsin the issue of abortion was first addressed in 1849, when lawmakers enacted a general prohibition on abortion after quickening (the mother's perception of fetal movement), providing an exception for the life of the mother. From 1973 until the Dobbs ruling, this statute was unenforceable due to Roe and subsequent rulings, however this law was reinstated after the Dobbs decision, making all abortions illegal unless preformed for the life of the mother. For many women in Wisconsin, this was perceived as an attack on their bodily autonomy. We, as obstetrician-gynecologists, heard their stories and saw a large influx of women requesting sterilization due to fear of being forced to carry an unplanned and undesired pregnancy to term. Our research aims to evaluate sterilizations performed at Meriter hospital for the year prior to the Dobbs decision and the year after. It will be a retrospective chart review. | 1 | Reviewing charts of female patients who underwent surgical sterilization at Meriter over the past 2 years | Epic compentency, HIPPA compliant | Will likely be exempted but submitting now | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Yes | Nettie Larson (PGY1) | Laura Hanks, lhanks@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucSCSBhi6Uqp2b6n3nyI_hrlVXU8e_wbEKtDcDE4LNWlagv8kCp04_g6TRmki8p0ls | |||||||||
| 12/01/2022 | mtlong@wisc.edu | Micah | Long | MD | Associate Professor | 920 | Anesthesiology | Research Electives for credit | Outcomes after In-Hospital Cardiac Arrest: We are finalizing creation of a code-registry locally, that will then become a multi-center outcomes registry. We will be using this registry to publish several efforts. First, we know that for out-of-hospital arrest and in pediatrics, patients who receive calcium have worse outcomes. We also know that calcium is given during many arrests at UW; we feel this may negatively impact mortality. We will compare time-stratified outcomes for patients who had in-hospital arrest and who received calcium. Second, we know that critical care in general has a plethora of negative cognitive, psychiatric and functional deficits that follow, grouped together as what is called the "Post Intensive Care Syndrome." We are establishing a battery of tests to follow patients who suffered from cardiac arrest at our institution to determine our cognitive outcomes for in-hospital arrest, and for out-of-hospital arrest with and without ECMO-supported CPR. Finally, if time allows, we have projects related to CPR hand-positioning and localizing the optimal site with ultrasound. ____________________________________________________________________________ Role - Data review of code outcomes including review of code sheets. IRB submissions for multicenter work and for neuro-outcome tracking. Finalize testing battery for neurocognitive outcomes via literature search and mentor guidance. Stats plan and interpret for calcium-related outcomes. Possible grant submission for neuro-outcome and networking the code registry.; IRB Status - Submitted, expecting results within 6-weeks; Skills - Medical School Matriculants | Critical Care | Emergency Medicine | Critical Care | John T. Dollerschell | dollerschell@wisc.edu | Anesthesiology | Critical Care & Cardiothoracic Anesthesiology | Outcomes after In-Hospital Cardiac Arrest | We are finalizing creation of a code-registry locally, that will then become a multi-center outcomes registry. We will be using this registry to publish several efforts. First, we know that for out-of-hospital arrest and in pediatrics, patients who receive calcium have worse outcomes. We also know that calcium is given during many arrests at UW; we feel this may negatively impact mortality. We will compare time-stratified outcomes for patients who had in-hospital arrest and who received calcium. Second, we know that critical care in general has a plethora of negative cognitive, psychiatric and functional deficits that follow, grouped together as what is called the "Post Intensive Care Syndrome." We are establishing a battery of tests to follow patients who suffered from cardiac arrest at our institution to determine our cognitive outcomes for in-hospital arrest, and for out-of-hospital arrest with and without ECMO-supported CPR. Finally, if time allows, we have projects related to CPR hand-positioning and localizing the optimal site with ultrasound. | 1 | Data review of code outcomes including review of code sheets. IRB submissions for multicenter work and for neuro-outcome tracking. Finalize testing battery for neurocognitive outcomes via literature search and mentor guidance. Stats plan and interpret for calcium-related outcomes. Possible grant submission for neuro-outcome and networking the code registry. | Mostly computer work, will need lots of mentorship but can be quite independent. | Medical School Matriculants | Submitted, expecting results within 6-weeks | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan, PhD jasullivan@wisc.edu | Micah Long, mtlong@wisc.edu -- Co-Mentor: John T. Dollerschell dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufmlOQMemXgbiLKBdTW1bgz2gL7IWLnqKZ74orGSASk5TGPB_egKfhkkMIE6FsqaeQ | |
| kschaumberg@wisc.edu | Katherine | Schaumberg | PhD | Assistant Professor | Psychiatry | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Adolescent Weight Trajectories and Eating Disorder Risk : The project will use clinical growth chart data along with indicators of eating disorder onset to define appropriate, individualized levels of weight restoration during eating disorder recovery. We will recruit a sample of youth in partial or full recovery from EDs to clarify whether weight restoration to premorbid weight status, as developmentally indicated, associates with other markers of eating disorder recovery and relapse both cross-sectionally and longitudinally. We will simultaneously develop a graphical tool for clinicians to clarify expected body weight across development, derived from growth chart data and age of eating disorder onset. For more information on the EMBARK Lab, see : embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Recruitment; Assessment of Adolescent Participants; Development of Clinician Tools; IRB management; IRB Status - Not Yet Submitted; Skills - Interest in working with adolescents; clinical interviewing | Adolescent Weight Trajectories and Eating Disorder Risk | The project will use clinical growth chart data along with indicators of eating disorder onset to define appropriate, individualized levels of weight restoration during eating disorder recovery. We will recruit a sample of youth in partial or full recovery from EDs to clarify whether weight restoration to premorbid weight status, as developmentally indicated, associates with other markers of eating disorder recovery and relapse both cross-sectionally and longitudinally. We will simultaneously develop a graphical tool for clinicians to clarify expected body weight across development, derived from growth chart data and age of eating disorder onset. For more information on the EMBARK Lab, see : embark.psychiatry.wisc.edu | 0 | Recruitment; Assessment of Adolescent Participants; Development of Clinician Tools; IRB management | Student will work as part of laboratory team | Interest in working with adolescents; clinical interviewing | Not Yet Submitted | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | Yes | Lauren Pictor; lpictor@wisc.edu; kayo Tada; kkern3@wisc.edu | Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueqvhtnwC8ih8-R6zYr1VTdc_dkmDQIzVodIeMzW9S2eVzHk-rHJ95rzA2FDYcSdsI | ||||||||||
| kschaumberg@wisc.edu | Katherine | Schaumberg | PhD | Assistant Professor | Psychiatry | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Multimodal Assessment of Exercise in Eating Disorders: This project evaluates exercise response among individuals with eating disorders to 1) characterize variability in biobehavioral response to in-lab exposure to moderate-intensity exercise among those with and without EDs; 2) create and refine tasks that capture engagement of reward- and threat-related systems during exercise. Our sample includes adolescent and young adult females (aged 14-22y) with a DSM-5 restrictive-spectrum ED diagnosis (AN; atypical AN; AN-spectrum OSFED), and age-matched healthy controls (HC). We examine multi-modal response (self-report state body image and affect, model-based learning, neurotransmitter shifts) to an acute bout of exercise using two novel exercise tasks, one in which participants are asked to drink a high-calorie beverage prior to exercise to trigger threat and capture threat-reduction mechanisms of exercise, and a second task primarily assessing the rewarding features of exercise. embark lab website: embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Clinical Recruitment; Phlebotomy; Assessment; IRB Status - Approved; Skills - Interest in working with adolescents | Multimodal Assessment of Exercise in Eating Disorders | This project evaluates exercise response among individuals with eating disorders to 1) characterize variability in biobehavioral response to in-lab exposure to moderate-intensity exercise among those with and without EDs; 2) create and refine tasks that capture engagement of reward- and threat-related systems during exercise. Our sample includes adolescent and young adult females (aged 14-22y) with a DSM-5 restrictive-spectrum ED diagnosis (AN; atypical AN; AN-spectrum OSFED), and age-matched healthy controls (HC). We examine multi-modal response (self-report state body image and affect, model-based learning, neurotransmitter shifts) to an acute bout of exercise using two novel exercise tasks, one in which participants are asked to drink a high-calorie beverage prior to exercise to trigger threat and capture threat-reduction mechanisms of exercise, and a second task primarily assessing the rewarding features of exercise. embark lab website: embark.psychiatry.wisc.edu | 0 | Clinical Recruitment; Phlebotomy; Assessment | Student will work as part of a laboratory team | Interest in working with adolescents | Approved | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | Lauren Pictor; lpictor@wisc.edu; kayo Tada: kkearn3@wisc.edu | Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufbDZMBRsT4lf1npMiCyvuVMWo6P5WSQ2X4tbjJXS2Aodi6w5ckimw9pJAIsQwY-mU | ||||||||||
| 12/01/2022 | mmathur@wisc.edu | Mala | Mathur | MD MPH | Associate Professor of Pediatrics | 0 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Integrative Health Research Team: Project Description: Integrative health is the use of conventional medical treatments and evidence based complementary treatments such as mindfulness. Mindfulness practices may be beneficial for parents and children to promote wellness, reduce stress, improve relational health and impact mental and physical health outcomes. In working with the Department of Pediatrics Integrative Health Research Team, you will have an opportunity to explore different research methodologies and contribute to a project that addresses the overall well-being of children and families. Some of our past projects have focused on ways to understand the perspective of parents in learning about Mindfulness practices. Current and future projects may include: designing a survey to serve as a needs assessment to understand what integrative health needs families have at UW Health, a content analysis project examining the availability of Mindfulness websites and apps for parents and children, or the evaluation of a Parenting/Caregiver Mindfulness Retreat and its effects on the relational health between parents/caregivers and their children. Our team is open to other projects and ideas related to integrative health. ____________________________________________________________________________ Role - Students may choose to be involved in idea generation, study design, data collection and analysis and writing up this work by developing an abstract for submission to local and/or national conferences. In the past, some Shapiro students have chosen to write up their work as a manuscript for submission to a journal.; IRB Status - We would work to submit an IRB if needed based on the project type; Skills - Ability to work on a team, an interest in learning about integrative health and research methodologies. | General Pediatric and Adolescent Medicine | Brad Kerr | bkerr@wisc.edu | Pediatrics | General Pediatrics and Adolescent Medicine | Integrative Health Research Team | Project Description: Integrative health is the use of conventional medical treatments and evidence based complementary treatments such as mindfulness. Mindfulness practices may be beneficial for parents and children to promote wellness, reduce stress, improve relational health and impact mental and physical health outcomes. In working with the Department of Pediatrics Integrative Health Research Team, you will have an opportunity to explore different research methodologies and contribute to a project that addresses the overall well-being of children and families. Some of our past projects have focused on ways to understand the perspective of parents in learning about Mindfulness practices. Current and future projects may include: designing a survey to serve as a needs assessment to understand what integrative health needs families have at UW Health, a content analysis project examining the availability of Mindfulness websites and apps for parents and children, or the evaluation of a Parenting/Caregiver Mindfulness Retreat and its effects on the relational health between parents/caregivers and their children. Our team is open to other projects and ideas related to integrative health. | 2 | Students may choose to be involved in idea generation, study design, data collection and analysis and writing up this work by developing an abstract for submission to local and/or national conferences. In the past, some Shapiro students have chosen to write up their work as a manuscript for submission to a journal. | Moderate | Ability to work on a team, an interest in learning about integrative health and research methodologies. | We would work to submit an IRB if needed based on the project type | No | Yes | Yes | MPH students, PhD students | Unsure / Depends | Yes | Christine Richards (crichards9@wisc.edu) | Mala Mathur, mmathur@wisc.edu -- Co-Mentor: Brad Kerr bkerr@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufI_m9pJRr_7oTAAeL7Inl0Jwp9S8IipJM8d8EGaFGVDRP04vTz6K-T4Bh7IETysLo | |||
| 12/02/2022 | jchurpek@wisc.edu | Jane | Churpek | MD, MS | Assistant Professor | Other | Shorter term projects | Autoimmunity and rheumatologic manifestations of telomere biology disorders: Telomere biology disorders (TBD) are a group of inherited syndromes characterized by defective telomere maintenance and multiorgan system pathologies, including bone marrow failure, AML/MDS, pulmonary fibrosis, cirrhosis, and predisposition to head and neck cancer. Autoimmune disease is also observed frequently in patients with TBD, but the full spectrum and prevalence of autoimmunity and rheumatologic manifestations in TBD is not well-defined. The purpose of this project is to determine whether TBD is associated with autoimmunity and define the prevalence and natural history of rheumatologic phenotypes among patients within the UW TBD registry. The UW TBD registry has already been established but requires expansion and additional data collection for the purpose of this project. ____________________________________________________________________________ Role - The student will take the lead on performing chart review and data collection of the approximately 20-30 patients within the UW TBD registry. The student will then work with the team to analyze data and prepare an abstract and ultimately a manuscript for publication. ; IRB Status - IRB will be approved at the time of project start.; Skills - None required but proficiency with Epic preferred. Will need to be HIPAA compliant. | Hematology/Oncology | Lauren Banaszak, MD (fellow) | lbanaszak@uwhealth.org | Other | Hematology/Oncology | Autoimmunity and rheumatologic manifestations of telomere biology disorders | Telomere biology disorders (TBD) are a group of inherited syndromes characterized by defective telomere maintenance and multiorgan system pathologies, including bone marrow failure, AML/MDS, pulmonary fibrosis, cirrhosis, and predisposition to head and neck cancer. Autoimmune disease is also observed frequently in patients with TBD, but the full spectrum and prevalence of autoimmunity and rheumatologic manifestations in TBD is not well-defined. The purpose of this project is to determine whether TBD is associated with autoimmunity and define the prevalence and natural history of rheumatologic phenotypes among patients within the UW TBD registry. The UW TBD registry has already been established but requires expansion and additional data collection for the purpose of this project. | 1 | The student will take the lead on performing chart review and data collection of the approximately 20-30 patients within the UW TBD registry. The student will then work with the team to analyze data and prepare an abstract and ultimately a manuscript for publication. | None required but proficiency with Epic preferred. Will need to be HIPAA compliant. | IRB will be approved at the time of project start. | No | No (plan to use Dean's Office Funds) | Yes | Genetic Counseling students, UW undergraduates interested in research | No | No | Lauren Banaszak (lbanaszak@uwhealth.org) | Jane Churpek, jchurpek@wisc.edu -- Co-Mentor: Lauren Banaszak, MD (fellow) lbanaszak@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufgXw3LNpgSwfGWY9HU7WYqFAqQVJoa4YQ0upB-FgxWXaIRCGgN6XoHxFzLo83tBXc | |||||
| 12/03/2022 | hchang@dermatology.wisc.edu | Hao | Chang | PhD | Assistant Professor | 6.082.623.602 | Dermatology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Role of Frizzled signaling in melanoma: The planar cell polarity (PCP) pathway controls tissue polarity during development by regulating the directional movement of cells and aligning them to the tissue axes. Defects in PCP cause many developmental disorders in humans, including open neural tube, deafness, polycystic kidney disease, axon guidance defects, and cleft palate. In addition to the critical role in patterning embryonic tissues during development, emerging evidence also suggests that PCP is involved in cancers by promoting tumor cell migration and invasion. Although limited information is available regarding the PCP pathway in certain cancers, its involvement in skin cancer is unknown. Our goal is to uncover the role and mechanisms of the PCP pathway in skin cancers, especially melanoma, so novel treatment strategies can be developed. We focus on Frizzled (FZD) family of PCP genes since many of them are highly expressed in human melanoma cell lines and patient samples. Our recently published paper demonstrated the critical role of FZD6 in promoting melanoma cell invasion and metastasis. In this project, we will focus on the other Frizzled family member, FZD7, and determine the effects of overexpression or knockdown/knockout of FZD7 in melanoma cells. ____________________________________________________________________________ Role - Student will work in the above project and study the role and functional significance of FZD7 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cells lines, cell proliferation, invasion and migration assays, cell cycle analysis, and RT-qPCR and Western techniques for gene and protein expression analyses. ; IRB Status - N/A; Skills - Knowledge of cell culture and basic laboratory techniques is preferred but not required. | Role of Frizzled signaling in melanoma | The planar cell polarity (PCP) pathway controls tissue polarity during development by regulating the directional movement of cells and aligning them to the tissue axes. Defects in PCP cause many developmental disorders in humans, including open neural tube, deafness, polycystic kidney disease, axon guidance defects, and cleft palate. In addition to the critical role in patterning embryonic tissues during development, emerging evidence also suggests that PCP is involved in cancers by promoting tumor cell migration and invasion. Although limited information is available regarding the PCP pathway in certain cancers, its involvement in skin cancer is unknown. Our goal is to uncover the role and mechanisms of the PCP pathway in skin cancers, especially melanoma, so novel treatment strategies can be developed. We focus on Frizzled (FZD) family of PCP genes since many of them are highly expressed in human melanoma cell lines and patient samples. Our recently published paper demonstrated the critical role of FZD6 in promoting melanoma cell invasion and metastasis. In this project, we will focus on the other Frizzled family member, FZD7, and determine the effects of overexpression or knockdown/knockout of FZD7 in melanoma cells. | 1 | Student will work in the above project and study the role and functional significance of FZD7 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cells lines, cell proliferation, invasion and migration assays, cell cycle analysis, and RT-qPCR and Western techniques for gene and protein expression analyses. | Knowledge of cell culture and basic laboratory techniques is preferred but not required. | N/A | Yes | Yes | Yes | PhD students | Unsure / Depends | No | Mary Poellinger |
Hao Chang, hchang@dermatology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueVjzdHuBzwfwz3-WNenBSpFjzxHkGe_-nTbQHTcfZlzb-FZkjeNmihPKTevaD7PZY | |||||||||
| 12/04/2022 | abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MPH, CPE, FASA | Medical Director, Pain Medicine | Anesthesiology | Shorter term projects, Research Electives for credit | Radiofrequency ablation for knee pain: We will do chart review to identify outcomes following knee radio frequency ablation for treating chronic pain ____________________________________________________________________________ Role - Data collection and article writing; IRB Status - We have a waiver; Skills - data collection and writing skills | Radiofrequency ablation for knee pain | We will do chart review to identify outcomes following knee radio frequency ablation for treating chronic pain | 2 | Data collection and article writing | data collection and writing skills | We have a waiver | No | Department usually covers this cost | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | Jeremy Sullivan, jasullivan@wisc.edu | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudFOPV9YWkAn3c2tn3OG7-_nlfwkV-8GpiwaWSTsef64Xuq9-6dn3au7XdJpjAcgks | ||||||||||
| 12/04/2022 | abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MPH, CPE, FASA | Medical Director, Pain Medicine | Anesthesiology | Shorter term projects, Research Electives for credit | outcomes of radiofrequncy ablation of the cervical spine: data collection on outcomes following cervical radio frequency ablation for treating pain ____________________________________________________________________________ Role - data collection and article writing; IRB Status - we have a waiver; Skills - data collection and writing skills | outcomes of radiofrequncy ablation of the cervical spine | data collection on outcomes following cervical radio frequency ablation for treating pain | 1 | data collection and article writing | data collection and writing skills | we have a waiver | No | Department usually covers this cost | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | Jeremy Sullivan, jasullivan@wisc.edu | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufZO0bZBVexnsZOKEj96sZw6jvxR6KT3FosKlz8D_uC0xSDIP8fSnbun-75GI63ke8 | ||||||||||
| ayusodomingu@wisc.edu | Jose | Ayuso | PhD | Assistant Professor | 16.084.242.754 | Dermatology | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Study of cell adoptive immunotherapies in organ-on-a-chip models: In this project we leverage advanced organ-on-a-chip platforms to study several aspects of cancer immunotherapy. We will focus on therapies based on the use of natural killer (NK) cells, which are part of the innate immune system and have cytotoxic capacity against malignant cells. NK cells will be isolated from blood samples and culture in the lab for further expansion and differentiation. Next, we will expose them to tumor cells (e.g., melanoma, squamous cell carcinoma, glioblastoma) to monitor their capacity to destroy tumor cells. We will evaluate multiple aspects of NK cell biology such as the capacity to establish a memory-like response, immune exhaustion, etc. ____________________________________________________________________________ Role - The student will use microfluidic and organ-on-a-chip devices to study critical aspects of cancer immunotherapy, with special emphasis on adoptive cell therapy. The candidate will work with different techniques related with immune cell isolation, cell culture, fluorescence microscopy, microdevice fabrication, engineering, and molecular biology. Using this approach, the student will monitor immune cell migration, cytotoxicity against tumor cells, or immune exhaustion in order to improve the capacity of the immune system to fight against solid tumors. Other aspects that the student can nurture are hypothesis formulation, data analysis, data presentation, and scientific writing. Our lab is a multidisciplinary and diverse group of engineers and biologists that work in close collaboration with multiple physicians across the UW-Madison to improve the translation of our studies into the clinic.; IRB Status - N/A; Skills - Previous experience in cell culture is highly recommended | Other | Study of cell adoptive immunotherapies in organ-on-a-chip models | In this project we leverage advanced organ-on-a-chip platforms to study several aspects of cancer immunotherapy. We will focus on therapies based on the use of natural killer (NK) cells, which are part of the innate immune system and have cytotoxic capacity against malignant cells. NK cells will be isolated from blood samples and culture in the lab for further expansion and differentiation. Next, we will expose them to tumor cells (e.g., melanoma, squamous cell carcinoma, glioblastoma) to monitor their capacity to destroy tumor cells. We will evaluate multiple aspects of NK cell biology such as the capacity to establish a memory-like response, immune exhaustion, etc. | 0 | The student will use microfluidic and organ-on-a-chip devices to study critical aspects of cancer immunotherapy, with special emphasis on adoptive cell therapy. The candidate will work with different techniques related with immune cell isolation, cell culture, fluorescence microscopy, microdevice fabrication, engineering, and molecular biology. Using this approach, the student will monitor immune cell migration, cytotoxicity against tumor cells, or immune exhaustion in order to improve the capacity of the immune system to fight against solid tumors. Other aspects that the student can nurture are hypothesis formulation, data analysis, data presentation, and scientific writing. Our lab is a multidisciplinary and diverse group of engineers and biologists that work in close collaboration with multiple physicians across the UW-Madison to improve the translation of our studies into the clinic. | Previous experience in cell culture is highly recommended | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students | Unsure / Depends | No | Mary Poellinger |
Jose Ayuso, ayusodomingu@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueHqEYWMUrNqoP246nHftX397wX_DqnIik99nNyVvGk7lpUpYTA5F0EjUlruNjSQGY | |||||||||
| 12/05/2022 | knavel@wisc.edu | Erica | Knavel Koepsel | MD | Assistant Professor | 8.477.573.521 | Radiology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Evaluating outcomes for initial MRI guided interventions: We have started an interventional MRI program here at UW and the VA and we are in our first year of treating patients. Treating patients in the MRI is not currently not performed anywhere else in the state and in only a handful of sites in the country. We are looking to evaluate and report our initial 1 year experience. The procedures that we perform in the MR include: Prostate cryoablation, prostate biopsies, vascular malformation cryo and laser ablations. Each procedure type may be a separate study. ____________________________________________________________________________ Role - chart review, analyze data, write up abstract/manuscripts; IRB Status - Retrospective IRB will be obtained but is not submitted; Skills - Excel data management | Interventional radiology | Evaluating outcomes for initial MRI guided interventions | We have started an interventional MRI program here at UW and the VA and we are in our first year of treating patients. Treating patients in the MRI is not currently not performed anywhere else in the state and in only a handful of sites in the country. We are looking to evaluate and report our initial 1 year experience. The procedures that we perform in the MR include: Prostate cryoablation, prostate biopsies, vascular malformation cryo and laser ablations. Each procedure type may be a separate study. | 1 | chart review, analyze data, write up abstract/manuscripts | Excel data management | Retrospective IRB will be obtained but is not submitted | No | Depends on stipend amount | Yes | Not currently available to mentor other students | No | No | N/A | Erica Knavel Koepsel, knavel@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuchTFbiRn4EHEDp9NnjXpGfH_7Fu4MdpEtgoiSY3I18_5A520j04md0sg01CH0x00U | ||||||||
| 12/05/2022 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Chairman | 608 | Neurological Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experience some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native Americans have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. ____________________________________________________________________________ Role - MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations. ; IRB Status - IRB approved 2019-1550; Skills - Curious / multitasking / willing to learn new skills / teamwork | Carol Mitchell, PhD | ccm@medicine.wisc.edu | Medicine | Cardiovascular | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation | American Indian/Alaska Native (AI/AN) populations across the country experience some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native Americans have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. | 1 | MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations. | somewhat independence | Curious / multitasking / willing to learn new skills / teamwork | IRB approved 2019-1550 | WPP funding | Yes | Yes | Not currently available to mentor other students | No | Yes | Stephanie Wilbrand (wilbrand@neurosurgery.wisc.edu) - research administrator & Niki Virnig (virnig@neurosurgery.wisc.edu) - Department administrator | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Carol Mitchell, PhD ccm@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufmk8AYMxpaO68r98knjyLI1-c2oilbT9sTsNVLdYtIYbrHTmU_1A8aB9QSI05KISE | ||||
| 12/06/2022 | rengen@wisc.edu | Rachel | Engen | MD, MS | Assistant Professor | 6.176.201.170 | Pediatrics | Shorter term projects | Outcomes of BK infection in pediatric kidney transplantation: BK virus nephropathy is a devastating complication of kidney transplant with limited proven treatments. This study is a case series reporting outcomes for pediatric kidney transplant recipients with BK DNAemia and BK nephropathy who are managed with a combination of intravenous immunoglobulin (IVIg) and cidofovir. Outcomes will include resolution of BK nephropathy, renal function, and complications like tubular dysfunction. ____________________________________________________________________________ Role - Role will include a review of the literature, development of a study proposal, collection of data from HealthLink to supplement an existing data set, and creation of figures for publication. Goal will be submission of an abstract. The student may be involved in drafting a manuscript, if desired.; IRB Status - Pending; Skills - Human subjects research certification (CITI), comfort with pubmed searches, access to and ability to use HealthLink, willingness to learn about pediatric kidney transplantation and BK nephropathy | Nephrology | Sharon Bartosh | smbartosh@wisc.edu | Pediatrics | Outcomes of BK infection in pediatric kidney transplantation | BK virus nephropathy is a devastating complication of kidney transplant with limited proven treatments. This study is a case series reporting outcomes for pediatric kidney transplant recipients with BK DNAemia and BK nephropathy who are managed with a combination of intravenous immunoglobulin (IVIg) and cidofovir. Outcomes will include resolution of BK nephropathy, renal function, and complications like tubular dysfunction. | 1 | Role will include a review of the literature, development of a study proposal, collection of data from HealthLink to supplement an existing data set, and creation of figures for publication. Goal will be submission of an abstract. The student may be involved in drafting a manuscript, if desired. | Human subjects research certification (CITI), comfort with pubmed searches, access to and ability to use HealthLink, willingness to learn about pediatric kidney transplantation and BK nephropathy | Pending | No | No (plan to use Dean's Office Funds) | Yes | MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | No | N/A | Rachel Engen, rengen@wisc.edu -- Co-Mentor: Sharon Bartosh smbartosh@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudE8XY1l_18e5mC8NBTbTgFx-quLMR7vedwvUOwBjhGYrUnvtwDyKo56DYkLfrMs5g | |||||
| 12/06/2022 | rengen@wisc.edu | Rachel | Engen | MD, MS | Assistant Professor | 6.176.201.170 | Pediatrics | Shorter term projects | Long-term IVIg for chronic rejection in pediatric kidney transplantation: Antibody-mediated rejection and chronic rejection are the leading causes of graft failure in kidney transplantation, but there is no established treatment for these conditions. This study will be a case series reporting on outcomes for pediatric kidney transplant recipients treated with long-term intravenous immunoglobulin (IVIg). Outcomes will include graft survival, renal function, improvement in donor-specific antibody levels, and complications of treatment. ____________________________________________________________________________ Role - Student researchers will be perform a literature review, generate a study proposal, collect data from HealthLink medical records to supplement an existing dataset, and generate figures for use in publication. The goal of the project will be submission of an abstract. If the study proceeds to full manuscript for publication, the student researcher may be involved with writing the manuscript if they wish.; IRB Status - pending; Skills - Human Subjects Research certification (CITI training), facility with pubmed searches, ability to use HealthLink for data collection, comfort with using Word/Excel to generate publication-quality tables and figures, willingness to learn about kidney transplantation, chronic rejection, and research practices | Nephrology | Sharon Bartosh | smbartosh@wisc.edu | Pediatrics | Long-term IVIg for chronic rejection in pediatric kidney transplantation | Antibody-mediated rejection and chronic rejection are the leading causes of graft failure in kidney transplantation, but there is no established treatment for these conditions. This study will be a case series reporting on outcomes for pediatric kidney transplant recipients treated with long-term intravenous immunoglobulin (IVIg). Outcomes will include graft survival, renal function, improvement in donor-specific antibody levels, and complications of treatment. | 1 | Student researchers will be perform a literature review, generate a study proposal, collect data from HealthLink medical records to supplement an existing dataset, and generate figures for use in publication. The goal of the project will be submission of an abstract. If the study proceeds to full manuscript for publication, the student researcher may be involved with writing the manuscript if they wish. | Students will meet regularly with their mentor, and mentors will be available by email for questions as they arise. Students will be expected to work independently on the various steps of the project in between meetings with their mentor. | Human Subjects Research certification (CITI training), facility with pubmed searches, ability to use HealthLink for data collection, comfort with using Word/Excel to generate publication-quality tables and figures, willingness to learn about kidney transplantation, chronic rejection, and research practices | pending | No | No (plan to use Dean's Office Funds) | Yes | MPH students | No | No | N/A | Rachel Engen, rengen@wisc.edu -- Co-Mentor: Sharon Bartosh smbartosh@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudGSt7wYQn1CkYUJpHCdT02lXYBE9kDxqNZlj9iN76of-bxY9hVmQinJsc1DWvORnI | ||||
| 12/06/2022 | bgillick@wisc.edu | Bernadette | Gillick | PhD, MSPT, PT | Associate Professor Department of Pediatrics, Director Waisman Pediatric Neuromodulation Laboratory, Director of Research Design- ICTR | 6.082.627.457 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development: ‘Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development’ investigating recovery and development over the first two years of life after early brain injury and high-risk for developing Cerebral Palsy. Neuroimaging Processing with Brain Imaging Segmentation and Corticospinal Tract Analysis from this NIH R01 funded study. https://pnl.waisman.wisc.edu/research/ ____________________________________________________________________________ Role - Neuroimaging Assessments and Analysis; IRB Status - Approved and Currently Recruiting; Skills - Minimal | Dev Med/Peds Rehab | Other | Biomedical Engineering | Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development | ‘Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development’ investigating recovery and development over the first two years of life after early brain injury and high-risk for developing Cerebral Palsy. Neuroimaging Processing with Brain Imaging Segmentation and Corticospinal Tract Analysis from this NIH R01 funded study. https://pnl.waisman.wisc.edu/research/ | 1 | Neuroimaging Assessments and Analysis | Minimal | Minimal | Approved and Currently Recruiting | Yes | Yes, but all dedicated to personnel. Would take on Shapiro with Department Funding | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | N/A | Bernadette Gillick, bgillick@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuee6DKQDP6TAzdfHARxwH5ok2bT6Y25tShd56R7Rb0z9hx1YaTsxOT-qu2rsx3wkso | |||||
| 12/06/2022 | bgillick@wisc.edu | Bernadette | Gillick | PhD, MSPT,PT | Associate Professor Department of Pediatrics, Director Waisman Pediatric Neuromodulation Laboratory, Director of Research Design- ICTR | 608 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | ‘Pediatric Teleneuromodulation’ : ‘Pediatric Teleneuromodulation’ study investigating home-based transcranial direct current stimulation with children and young adults with cerebral palsy. Developing improved, updated and potentially fully-automatic training materials for remote Teleneuromodulation based on study results from C-progress – using video recordings of sessions and existing materials. https://pnl.waisman.wisc.edu/research/ ____________________________________________________________________________ Role - Analysis and Assessment; IRB Status - Approved and Currently Recruiting; Skills - Minimal | Dev Med/Peds Rehab | Other | Biomedical Engineering | ‘Pediatric Teleneuromodulation’ | ‘Pediatric Teleneuromodulation’ study investigating home-based transcranial direct current stimulation with children and young adults with cerebral palsy. Developing improved, updated and potentially fully-automatic training materials for remote Teleneuromodulation based on study results from C-progress – using video recordings of sessions and existing materials. https://pnl.waisman.wisc.edu/research/ | 1 | Analysis and Assessment | Minimal | Minimal | Approved and Currently Recruiting | Yes | Through Peds Department | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | N/A | Bernadette Gillick, bgillick@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueCgAkcjVj0T1SbVFR2DpnCBk15QglWZxzvmeQvBQZENCWFmP9hTSm9704O2SL507w | |||||
| 12/07/2022 | ppickhardt2@uwhealth.org | Perry | Pickhardt | MD | Multiple potential radiology projects | 608 | Radiology | Shorter term projects, Research Electives for credit | Radiology: (Drs. Lubner & Pickhardt will discuss a variety of potential projects with the prospective Shapiro student, and a mutual decision on a specific project will be made, reflecting interest, need, and feasibility. Please note completing a Shapiro research project in the radiology department comes with a variety of additional learning opportunities including small group mentoring sessions, faculty lectures, clinical shadowing, financial support for meetings, etc) 1. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects); Other Quantitative/AI CT projects including automated assessment CT findings in liver disease including CT volumetrics, Liver surface nodularity, radiomics-past cohorts include HCV, NAFLD, could look at large pooled cohort; automated assessment of renal stone volumes 2. General CT projects: Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, assessment of perineural invasion in GI malignancies, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc; Workflow/technology projects around novel CT techniques such as dual energy CT, photon counting CT, CT protocols(e.g. CT Esophagram, CT UGI series etc), deep learning reconstruction techniques (DLIR), CT dose, consequences of changing kV and impact on HU measurements. 3. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would complications of biopsy in adenoma or adenoma like lesions, US pancreas biopsy, US biopsy of HCC 4. CT radiologic pathologic correlation project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT colonography related projects 6. Miscellaneous non CT clinical projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc ____________________________________________________________________________ Role - Image review, image and EMR data collection, basic statistical analysis, abstract/manuscript preparation if desired; IRB Status - Approved; Skills - PACS, EMR navigation, Excel, data management | Abdominal Imaging and Intervention | Meghan Lubner | mlubner@uwhealth.org | Radiology | Radiology | Radiology | (Drs. Lubner & Pickhardt will discuss a variety of potential projects with the prospective Shapiro student, and a mutual decision on a specific project will be made, reflecting interest, need, and feasibility. Please note completing a Shapiro research project in the radiology department comes with a variety of additional learning opportunities including small group mentoring sessions, faculty lectures, clinical shadowing, financial support for meetings, etc) 1. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects); Other Quantitative/AI CT projects including automated assessment CT findings in liver disease including CT volumetrics, Liver surface nodularity, radiomics-past cohorts include HCV, NAFLD, could look at large pooled cohort; automated assessment of renal stone volumes 2. General CT projects: Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, assessment of perineural invasion in GI malignancies, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc; Workflow/technology projects around novel CT techniques such as dual energy CT, photon counting CT, CT protocols(e.g. CT Esophagram, CT UGI series etc), deep learning reconstruction techniques (DLIR), CT dose, consequences of changing kV and impact on HU measurements. 3. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would complications of biopsy in adenoma or adenoma like lesions, US pancreas biopsy, US biopsy of HCC 4. CT radiologic pathologic correlation project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT colonography related projects 6. Miscellaneous non CT clinical projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc | 2 | Image review, image and EMR data collection, basic statistical analysis, abstract/manuscript preparation if desired | Moderate | PACS, EMR navigation, Excel, data management | Approved | No | Yes | Yes | Not currently available to mentor other students | No | Unsure / Depends | Lorene Seman, lseman@uwhealth.org | Perry Pickhardt, ppickhardt2@uwhealth.org -- Co-Mentor: Meghan Lubner mlubner@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudAinBVPxIfAr3s-AehdzxolmtG-iiKM7Xm-mP1RmwaSsR2dMPp9yWQu8-Jg8nRmco | |||
| 12/07/2022 | bcastor@medicine.wisc.edu | Brad | Astor | PhD, MPH | Professor | 0 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Systemic immune-inflammation index and Kidney Transplant Outcomes: Inflammation is a critical part of numerous disease processes. Higher intensity of inflammation is predictive of poor outcome in several settings, including chronic kidney disease and acute kidney injury (AKI). There are multiple individual biomarkers indicative of inflammation, but these may be substantially confounded by other factors. The systemic immune-inflammation index (SII), based on readily available measurements of platelets, neutrophils and lymphocytes, has been proposed as a simple comprehensive biomarker that is low-cost, convenient, and simultaneously reflects the inflammatory and immune status of patients. Recent studies have found that the SII predicts outcomes in cardiovascular disease, survival in patients with malignancy, and the incidence of contrast-induced CI-AKI. Only one small study has explored the association of SII with outcomes in kidney transplant recipients, who are at elevated risk of immune-mediated outcomes, including graft rejection, infection, and malignancy. The aim of this study is to assess the association of SII with specific immune-mediated outcomes in kidney transplant recipients. ____________________________________________________________________________ Role - Review existing literature on SII and its role in outcomes. Work with PI on designing analyses. Develop tables and figures for data presentation, Interpret analytic results. Draft abstract and manuscript.; IRB Status - IRB in place. Student may be added to existing protocol; Skills - Critical reading of literature; understanding of analytic results; scientific writing | Nephrology | Population Health Sciences | Systemic immune-inflammation index and Kidney Transplant Outcomes | Inflammation is a critical part of numerous disease processes. Higher intensity of inflammation is predictive of poor outcome in several settings, including chronic kidney disease and acute kidney injury (AKI). There are multiple individual biomarkers indicative of inflammation, but these may be substantially confounded by other factors. The systemic immune-inflammation index (SII), based on readily available measurements of platelets, neutrophils and lymphocytes, has been proposed as a simple comprehensive biomarker that is low-cost, convenient, and simultaneously reflects the inflammatory and immune status of patients. Recent studies have found that the SII predicts outcomes in cardiovascular disease, survival in patients with malignancy, and the incidence of contrast-induced CI-AKI. Only one small study has explored the association of SII with outcomes in kidney transplant recipients, who are at elevated risk of immune-mediated outcomes, including graft rejection, infection, and malignancy. The aim of this study is to assess the association of SII with specific immune-mediated outcomes in kidney transplant recipients. | 1 | Review existing literature on SII and its role in outcomes. Work with PI on designing analyses. Develop tables and figures for data presentation, Interpret analytic results. Draft abstract and manuscript. | Moderate | Critical reading of literature; understanding of analytic results; scientific writing | IRB in place. Student may be added to existing protocol | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | Unsure / Depends | Kathy R. Wirtz; Administrative Assistant | Brad Astor, bcastor@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucuXZIlD3bSUPvVPU-0UKNfyxo71wqnp7pwSAilU8DnkEQdvS7z4VrE0CPLxaMZ8Hg | ||||||
| fkaiksow@wisc.edu | Farah | Kaiksow | MD, MPP | Assistant Professor (CHS) | 6.087.709.997 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Diagnostic equity: measuring the association between diagnostic errors and neighborhood disadvantage: Diagnostic errors are common in medicine. Health care and outcomes have been found to be commonly associated with a patient's socioeconomic status. Little is known regarding the intersection of these two factors (diagnostic error and socioeconomic status) and how they might contribute to an individual's health and health care. This study aims to use a validated measure of socioeconomic status, the Area Deprivation Index (ADI), and a pre-existing diagnostic data error set, to measure for any association. Our hypothesis is that diagnostic errors are more common in individuals with higher ADI (more neighborhood disadvantage). ____________________________________________________________________________ Role - The student will be responsible for working with other researchers at the UW Center for Health Disparities Research (CHDR) to link ADI measurements to diagnostic error data, for basic data analysis/study design, and for writing up the results.; IRB Status - Approval not yet confirmed.; Skills - Basic knowledge of health equity paradigms. Knowledge of study design and/or statistical analysis (including programming) would be great, but is not necessary. | Hospital Medicine | Ann Sheehy, MD, MS, Associate Professor | asr@medicine.wisc.edu | Medicine | Hospital Medicine | Diagnostic equity: measuring the association between diagnostic errors and neighborhood disadvantage | Diagnostic errors are common in medicine. Health care and outcomes have been found to be commonly associated with a patient's socioeconomic status. Little is known regarding the intersection of these two factors (diagnostic error and socioeconomic status) and how they might contribute to an individual's health and health care. This study aims to use a validated measure of socioeconomic status, the Area Deprivation Index (ADI), and a pre-existing diagnostic data error set, to measure for any association. Our hypothesis is that diagnostic errors are more common in individuals with higher ADI (more neighborhood disadvantage). | 0 | The student will be responsible for working with other researchers at the UW Center for Health Disparities Research (CHDR) to link ADI measurements to diagnostic error data, for basic data analysis/study design, and for writing up the results. | Student should expect at least weekly in-person meetings and should be able to accomplish tasks on her/his own between those meetings. Mentors will be available daily, though, as questions/needs arise. | Basic knowledge of health equity paradigms. Knowledge of study design and/or statistical analysis (including programming) would be great, but is not necessary. | Approval not yet confirmed. | No | No (plan to use Dean's Office Funds) | Yes | MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | N/A | Farah Kaiksow, fkaiksow@wisc.edu -- Co-Mentor: Ann Sheehy, MD, MS, Associate Professor asr@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueOZyKnXwJoxtF4lRO0Z73F1ioaHOEY3oNFAqmlFRsnNkP5GUilgS_TlF5JmWD59Zs | ||||
| 12/09/2022 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Chair | 0 | Neurological Surgery | Shorter term projects | Pathophysiology of stroke, atherosclerosis and brain tumor: The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. We are also focusing on identification of blood biomarkers associated with stroke risk and outcome. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. ____________________________________________________________________________ Role - Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field.; IRB Status - Approved; Skills - Some exposure to basic lab technique. However, we will train. | Umadevi Wesley PhD, Distinguished Scientist/Research Professor | wesley@neurosurgery.wisc.edu | Neurological Surgery | Pathophysiology of stroke, atherosclerosis and brain tumor | The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. We are also focusing on identification of blood biomarkers associated with stroke risk and outcome. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. | 1 | Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. | Somewhat - Fairly independent | Some exposure to basic lab technique. However, we will train. | Approved | Yes | Yes | Yes | PhD students | Yes | No | N/A | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Umadevi Wesley PhD, Distinguished Scientist/Research Professor wesley@neurosurgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufjaPGBiZcrL_NpP_0Pae5S0PvHb7M7h2oPaDBnk4BqNo6kyq8lKMiyBHeNigffjBI | |||||
| 12/09/2022 | majid.afshar@wisc.edu | Majid | Afshar | MD, MS | Actionable Insights for Substance Use Prevention and Treatment with Multi-Modal Data Science | 3.125.459.462 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Substance Misuse Data Commons: Substance misuse is a complex, multifaceted problem that requires a comprehensive and coordinated response from governments, healthcare providers, and other stakeholders. Opioid misuse, non-opioid illicit use (i.e., cocaine, methamphetamine), and alcohol misuse can lead to repeated encounters with emergency departments and first responders. Substance misuse remains a leading cause of hospital readmissions, and the opioid epidemic continues unabated with rapid increases in rates of overdose. An obstacle to comprehensive population health research in substance misuse is the isolation of health systems from the society around them. The data collected by state agencies (Department of Health Services, Department of Corrections, etc.) contain valuable information about out-of-hospital events not documented in the electronic health record (EHR), and public health surveillance systems contain limited data from the EHR. Better methods are needed to integrate this information and ensure confidentiality and security of patients and provide researchers analytic tools that will inform healthcare delivery pathways and public health policy decisions. In our work - supported by the NIH Office of Data Science Strategy - we built a Substance Misuse Data Commons (SMUDC) using privacy-preserving record linkage to harmonize data from hospitalizations with conditions related to substance misuse. The SMUDC is a cloud-based cyberinfrastructure where stakeholders can work in an environment with data from previously siloed data sources through an interoperable and scalable platform. The goal of the SMUDC is to provide the first-of-its-kind informatics platform using academic-public-private partnerships to advance research in substance misuse prevention, treatment mapping, and other service delivery for clinical care. The Shapiro student will get involved in working across public health and EHR datasets to perform quality assessments and data wrangling activities that will serve models for predictive analytics. They will work alongside machine learning experts and informaticians. https://www.medicine.wisc.edu/apcc/icu-data-science-lab ____________________________________________________________________________ Role - Data Analyst and introduction health information exchange; IRB Status - approved; Skills - Any coding or database experience | Pulmonary/Critical Care | Biostatistics and Medical Informatics | Substance Misuse Data Commons | Substance misuse is a complex, multifaceted problem that requires a comprehensive and coordinated response from governments, healthcare providers, and other stakeholders. Opioid misuse, non-opioid illicit use (i.e., cocaine, methamphetamine), and alcohol misuse can lead to repeated encounters with emergency departments and first responders. Substance misuse remains a leading cause of hospital readmissions, and the opioid epidemic continues unabated with rapid increases in rates of overdose. An obstacle to comprehensive population health research in substance misuse is the isolation of health systems from the society around them. The data collected by state agencies (Department of Health Services, Department of Corrections, etc.) contain valuable information about out-of-hospital events not documented in the electronic health record (EHR), and public health surveillance systems contain limited data from the EHR. Better methods are needed to integrate this information and ensure confidentiality and security of patients and provide researchers analytic tools that will inform healthcare delivery pathways and public health policy decisions. In our work - supported by the NIH Office of Data Science Strategy - we built a Substance Misuse Data Commons (SMUDC) using privacy-preserving record linkage to harmonize data from hospitalizations with conditions related to substance misuse. The SMUDC is a cloud-based cyberinfrastructure where stakeholders can work in an environment with data from previously siloed data sources through an interoperable and scalable platform. The goal of the SMUDC is to provide the first-of-its-kind informatics platform using academic-public-private partnerships to advance research in substance misuse prevention, treatment mapping, and other service delivery for clinical care. The Shapiro student will get involved in working across public health and EHR datasets to perform quality assessments and data wrangling activities that will serve models for predictive analytics. They will work alongside machine learning experts and informaticians. https://www.medicine.wisc.edu/apcc/icu-data-science-lab | 2 | Data Analyst and introduction health information exchange | Yes | Any coding or database experience | approved | Yes | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students | No | Yes | Madeline Oguss | Majid Afshar, majid.afshar@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuca2o0cKN3yVWtdZDhBMLlLOsRrb05D8Mp5P3mhJ5au_mahYF5pQe_R8LJ6-VLF5Mo | ||||||
| 12/10/2022 | PLang@ortho.wisc.edu | Pamela | Lang | MD | Associate Professor | 6.082.656.516 | Orthopedics and Rehabilitation | Shorter term projects, Research Electives for credit | Pediatric Youth Knee Injury Registry Study: UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2023 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. ____________________________________________________________________________ Role - The student will be responsible for 1) Identifying, recruiting and enrolling participants. 2) Contacting participants who have not responded to specific inquiries, 3) Assist staff with scoring, editing and analyzing data we collect for this study, 4) Assist bio-mechanic faculty to segment MRIs of patella instability patients so the staff we can create a model to complement with the clinical and cadaver studies, 5) Work effectively and collaboratively with other team members. ; IRB Status - HS-IRB 2019-0028 - Approved; Skills - 1) Able to effectively interact with potential participants and their parents in clinc settings. 2) Edit and clean data in MS Excel spreadsheets and REDCap3) Work effectively and collaboratively with other team members. | Sports Medicine | Timothy McGuine | mcguine@ortho.wisc.edu | Orthopedics and Rehabilitation | Sports Medicine | Pediatric Youth Knee Injury Registry Study | UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2023 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. | 0 | The student will be responsible for 1) Identifying, recruiting and enrolling participants. 2) Contacting participants who have not responded to specific inquiries, 3) Assist staff with scoring, editing and analyzing data we collect for this study, 4) Assist bio-mechanic faculty to segment MRIs of patella instability patients so the staff we can create a model to complement with the clinical and cadaver studies, 5) Work effectively and collaboratively with other team members. | Moderate | 1) Able to effectively interact with potential participants and their parents in clinc settings. 2) Edit and clean data in MS Excel spreadsheets and REDCap3) Work effectively and collaboratively with other team members. | HS-IRB 2019-0028 - Approved | No | Yes | Yes | DPT students, MPH students | No | No | Josh Roth (Roth@ortho.wisc.edu) Heidi Abledinger (Ableidinger@ortho.wisc.edu) | Pamela Lang, PLang@ortho.wisc.edu -- Co-Mentor: Timothy McGuine mcguine@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucZngxhNCnt2BWc5un7WsZL-u_zPk34GC13G1J4nTXhcYBK9z0youoLU6i8sGNguoY | |||
| 12/12/2022 | Gibson@surgery.wisc.edu | Angela | Gibson | Md,PhD | Assistant Professor of Surgery | 6.082.659.574 | Surgery | possibly interested if longer commitment | Cytotoxicity of common cleansers on human skin: The Gibson laboratory is interested in wound healing related to acute and chronic wounds. There is controversy in the clinical literature surrounding the potential toxicity of various topical cleansing treatments for wound care, however most of these recommendations are related to in-vitro studies and it is unclear if the toxicity is clinically significant. We have recently shown cytotoxicity of a commonly used antimicrobial CHG on human skin and are looking to find an alternative for our clinical practice. It is known that there is a cost associated using commercially available cleanser that exceeds the cost of simple soap and water. The Gibson lab uses discarded human skin tissue for wound healing studies in various models. This project will evaluate the cytotoxicity of clinically used topical cleansers on human skin in an ex-vivo human skin wound model. Additionally, there are multiple other studies ongoing in the lab and if interested, the student could also be involved as time allows. ____________________________________________________________________________ Role - Researcher for main project, observer/research assistance for other projects; IRB Status - Exempt/approved; Skills - Preferred - cell culture/sterile technique | Acute Care and Regional General Surgery | Cytotoxicity of common cleansers on human skin | The Gibson laboratory is interested in wound healing related to acute and chronic wounds. There is controversy in the clinical literature surrounding the potential toxicity of various topical cleansing treatments for wound care, however most of these recommendations are related to in-vitro studies and it is unclear if the toxicity is clinically significant. We have recently shown cytotoxicity of a commonly used antimicrobial CHG on human skin and are looking to find an alternative for our clinical practice. It is known that there is a cost associated using commercially available cleanser that exceeds the cost of simple soap and water. The Gibson lab uses discarded human skin tissue for wound healing studies in various models. This project will evaluate the cytotoxicity of clinically used topical cleansers on human skin in an ex-vivo human skin wound model. Additionally, there are multiple other studies ongoing in the lab and if interested, the student could also be involved as time allows. | 0 | Researcher for main project, observer/research assistance for other projects | Moderately independent | Preferred - cell culture/sterile technique | Exempt/approved | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students | No | No | Aiping Liu, PhD | Angela Gibson, Gibson@surgery.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuePmA65AjLhAEvH2CzEjetM80AIde15evBQceFDqc0LSZ3oJce2AugPDFV1rMaUG-I | |||||||
| 12/12/2022 | elawrence@uwhealth.org | Edward | Lawrence | MD/PhD | Assistant Professor | Radiology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Artificial intelligence (AI) for detecting radiology report discrepancies and identifying challenging diagnoses: A perfect fit for a student interested in AI applications and radiology, this project explores the ability of AI to assist with cataloging challenging or positive radiology cases and to predict cases where the attending radiologist and trainee interpretations disagreed. This is particularly important overnight when UW radiology trainees operate in a completely independent capacity. Fully implemented, our work will be able to automatically flag studies that were challenging for trainees, catalog them for teaching review, and support evaluation for patterns of misses or common mistakes. An interested student would be able to hit the ground running since our research team has already collected a database of study details and reports from emergent head CTs and musculoskeletal radiographs [approximately 25,000 of each]. The research student would work with our team and learn about developing AI algorithm(s) regarding the detection and grading of discrepancies and pathologies. In addition to gaining a general understanding of clinical imaging research and the basics of AI, the research student will gain an understanding of natural language processing (NLP), a type of AI that processes language or text to delineate meaning, compare similarities, and predict characteristics of text data. Real world examples of NLP include email filters and smart assistants (e.g. Alexa). ____________________________________________________________________________ Role - The student will play an integral role to the overall project with a particular focus on evaluating the AI output for accuracy regarding discrepancy and pathology. This will be completed through evaluation of the report texts as well as through an electronic medical record search to see if the expected pathology was confirmed clinically and/or surgically and what follow-up studies or evaluation, if any, was completed. This clinical grounding of the project is vital both for creating a strong ground truth for AI algorithm evaluation and for understanding how the imaging and possible discrepancies affect clinical management. Advanced computer programming is not required or expected but interested students would have an opportunity to work with members of the research team to learn about more advanced components of AI development and training if interested. At the completion of the Shapiro summer project the student will have a stand-alone research project to present and could continue work with the research team for completion and dissemination of some of the larger research aims. The motivated student would have full support to act as a primary author on their own research manuscript for publication. This project would be completed within the department of radiology and the research student would have access to a compliment of departmental learning opportunities and support, including small group learning sessions, funding support, and clinical shadowing experiences that can be tailored to the interests of the student. ; IRB Status - Approved; Skills - No specific skills needed other than a positive attitude. We will train you on everything needed to complete the research project. | Abdominal Imaging and Intervention | Artificial intelligence (AI) for detecting radiology report discrepancies and identifying challenging diagnoses | A perfect fit for a student interested in AI applications and radiology, this project explores the ability of AI to assist with cataloging challenging or positive radiology cases and to predict cases where the attending radiologist and trainee interpretations disagreed. This is particularly important overnight when UW radiology trainees operate in a completely independent capacity. Fully implemented, our work will be able to automatically flag studies that were challenging for trainees, catalog them for teaching review, and support evaluation for patterns of misses or common mistakes. An interested student would be able to hit the ground running since our research team has already collected a database of study details and reports from emergent head CTs and musculoskeletal radiographs [approximately 25,000 of each]. The research student would work with our team and learn about developing AI algorithm(s) regarding the detection and grading of discrepancies and pathologies. In addition to gaining a general understanding of clinical imaging research and the basics of AI, the research student will gain an understanding of natural language processing (NLP), a type of AI that processes language or text to delineate meaning, compare similarities, and predict characteristics of text data. Real world examples of NLP include email filters and smart assistants (e.g. Alexa). | 1 | The student will play an integral role to the overall project with a particular focus on evaluating the AI output for accuracy regarding discrepancy and pathology. This will be completed through evaluation of the report texts as well as through an electronic medical record search to see if the expected pathology was confirmed clinically and/or surgically and what follow-up studies or evaluation, if any, was completed. This clinical grounding of the project is vital both for creating a strong ground truth for AI algorithm evaluation and for understanding how the imaging and possible discrepancies affect clinical management. Advanced computer programming is not required or expected but interested students would have an opportunity to work with members of the research team to learn about more advanced components of AI development and training if interested. At the completion of the Shapiro summer project the student will have a stand-alone research project to present and could continue work with the research team for completion and dissemination of some of the larger research aims. The motivated student would have full support to act as a primary author on their own research manuscript for publication. This project would be completed within the department of radiology and the research student would have access to a compliment of departmental learning opportunities and support, including small group learning sessions, funding support, and clinical shadowing experiences that can be tailored to the interests of the student. | No specific skills needed other than a positive attitude. We will train you on everything needed to complete the research project. | Approved | No | Yes | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | Yes | Tabassum Kennedy (tkennedy@uwhealth.org); Tyler Bradshaw, PhD (tbradshaw@wisc.edu) | Edward Lawrence, elawrence@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueHHTqb4bCiHY8Nq6AfPlQfGx0HwTBZunPGZnyXUjM5eiMaq9cSSJEWLUqDDE6ZclI | |||||||||
| 12/12/2022 | raalexanian@medicine.wisc.edu | Ruben | Alexanian | MD | Assistant Professor | 6.082.634.066 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Tissue Engineering Heart Valves: Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, hindered by periprocedural risk and long-term valve durability. Bioengineered, stem cell derived, heart valve scaffolds may provide a robust disease model for drug discovery and an alternative to future valve tissue engineering. The proposed study will utilize human pluripotent derived valve interstitial cells combined with decellularized valve extracellular matrix to construct a bioengineered heart valve scaffolds for disease modeling and tissue engineering. ____________________________________________________________________________ Role - The qualified candidate will conduct bench top research including cell culture and various molecular biology techniques. ; IRB Status - N/A; Skills - basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred | CARDIOLOGY | Tissue Engineering Heart Valves | Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, hindered by periprocedural risk and long-term valve durability. Bioengineered, stem cell derived, heart valve scaffolds may provide a robust disease model for drug discovery and an alternative to future valve tissue engineering. The proposed study will utilize human pluripotent derived valve interstitial cells combined with decellularized valve extracellular matrix to construct a bioengineered heart valve scaffolds for disease modeling and tissue engineering. | 1 | The qualified candidate will conduct bench top research including cell culture and various molecular biology techniques. | High | basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | No | Janay Walters - jkwalters@wisc.edu | Ruben Alexanian, raalexanian@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufPxCMmUX7TdyT_6sF5nJS2XuGU2xx1KWoKgs16PfG6Ioxn7zag0LPXbXiaJno23Rg | |||||||
| 12/12/2022 | vlcryns@medicine.wisc.edu | Vincent | Cryns | MD | Professor of Medicine; Chief, Division of Endocrinology | 608 | Medicine | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | 3rd Messenger Signaling in Cancer: Together with Richard Anderson's lab, we have discovered a direct link between two of the most common cancer drivers (p53 and PI3k/Akt) that were previously thought to be unrelated. We showed that lipid second messengers in the PI3K/Akt pathway bind to p53 in the nucleus to activate Akt by what we are calling a third messenger pathway. We are currently exploring how third messengers regulate cancer growth and whether inhibitors of this pathway can be used to treat cancer using cell and mouse models. Lab website:https://www.medicine.wisc.edu/endocrinology/cryns-lab ____________________________________________________________________________ Role - lab assistant; IRB Status - NA; Skills - NA | Endocrinology | 3rd Messenger Signaling in Cancer | Together with Richard Anderson's lab, we have discovered a direct link between two of the most common cancer drivers (p53 and PI3k/Akt) that were previously thought to be unrelated. We showed that lipid second messengers in the PI3K/Akt pathway bind to p53 in the nucleus to activate Akt by what we are calling a third messenger pathway. We are currently exploring how third messengers regulate cancer growth and whether inhibitors of this pathway can be used to treat cancer using cell and mouse models. Lab website:https://www.medicine.wisc.edu/endocrinology/cryns-lab | 1 | lab assistant | any and all experience levels are welcome | NA | NA | Yes | Yes | Yes | PhD students, UW undergraduates interested in research | No | No | Lori Chamberlin as of January 2023 | Vincent Cryns, vlcryns@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnue91QEjgew6VRcjjal9-8b_rQ6YRWIEBHgnn8zweG3N_vgtIIgHmKKaX2GVYFtZO9c | |||||||
| Aross@uwhealth.org | Andrew | Ross | MD MPH | Dr. | 503 | Radiology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Program factors predicting successful musculoskeletal radiology fellowship match: Most graduating radiology residents will apply for a one-year subspecialty fellowship after completing residency. For those interested in musculoskeletal radiology, fellowship applications are completed through the NRMP and subject to a Match. MSK radiology fellowship has only participated in the Match for the past 3 years and little is known about what predicts successful Match outcomes both from the applicant and program perspectives. ____________________________________________________________________________ Role - The student working on this project will be collecting data on MSK radiology fellowship programs from a variety of sources including web sites, social media, and NRMP reports and organizing the data for analysis. They'll work closely with the research team to produce the statistical analysis and write up the results as a meeting abstract, and if desired, as a manuscript for journal submission. Students rotating in the radiology department also have the opportunity to engage in a number of additional activities including faculty mentored small group sessions, career lectures, research support, and clinical shadowing. This provides an excellent avenue for learning more about radiology as a medical specialty and potential career. ; IRB Status - Project is IRB exempt; Skills - No specific skills are required although basic skills with spreadsheets is a plus. Everything else can be learned on the job. | Musculoskeletal Imaging and Intervention | Program factors predicting successful musculoskeletal radiology fellowship match | Most graduating radiology residents will apply for a one-year subspecialty fellowship after completing residency. For those interested in musculoskeletal radiology, fellowship applications are completed through the NRMP and subject to a Match. MSK radiology fellowship has only participated in the Match for the past 3 years and little is known about what predicts successful Match outcomes both from the applicant and program perspectives. | 0 | The student working on this project will be collecting data on MSK radiology fellowship programs from a variety of sources including web sites, social media, and NRMP reports and organizing the data for analysis. They'll work closely with the research team to produce the statistical analysis and write up the results as a meeting abstract, and if desired, as a manuscript for journal submission. Students rotating in the radiology department also have the opportunity to engage in a number of additional activities including faculty mentored small group sessions, career lectures, research support, and clinical shadowing. This provides an excellent avenue for learning more about radiology as a medical specialty and potential career. | Moderate. | No specific skills are required although basic skills with spreadsheets is a plus. Everything else can be learned on the job. | Project is IRB exempt | No | No personal funding but Radiology Department funding is available | Yes | Not currently available to mentor other students | Yes | No | Yang, Katie M |
Andrew Ross, Aross@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufa9JIz9Iz5sF7iHVaHKaL-f8e14OkAqv6w7o23iV-EsrKZpPs2GeNoyxIj7AWOf9A | ||||||||
| cakelm@wisc.edu | Cynthia | Kelm-Nelson | PhD | Scientist III | 414 | Surgery | Shorter term projects, Research Electives for credit | Treatments of vocal communication deficits in a Parkinson rat model : Parkinsons disease (PD) is the second most common age-related neurological disorder that dramatically affects health-related quality of life of the patient as well as places a substantial burden on caregivers and the healthcare system. As the current population ages, the prevalence is expected to double by 2030, affecting twice as many men as women. The hallmark of PD in the central nervous system is death of dopaminergic neurons in the substantia nigra which corresponds to the classic disease-associated movement disorders; however, in most cases, neuron death precedes clinical presentation of motor signs. The onset of the disease occurs at least a decade prior to diagnosis leaving a loss in therapeutic opportunity. Widespread sensorimotor deficits, including early-onset vocal communication impairments (e.g. dysphonia, dysarthria), impact 90% of individuals with PD. Despite a significant negative health impact, management of vocal dysfunction in PD is restricted by a disconnect between current treatments and an understanding of the underlying early disease pathology, resulting in a critical gap in knowledge that limits patient treatment. Additionally, there are no specific biomarkers test to diagnose PD. The primary objective of our lab’s current work is to identify early stage (prodromal) gene biomarkers and pathways linked to vocalization and that are involved in the early stages of disease. Our lab models early-stage vocal motor behavioral deficits using a phosphatase and tensin homolog (PTEN)-induced putative kinase 1 knockout (Pink1-/-) rat as well as rat neuron cell culture. Opportunities in the lab for summer 2023 include: 1. Drug repurposing and cell culture. Previously generated RNA-sequencing datasets have identified enriched genetic pathways and differentially expressed genes that are dysregulated in the Pink1-/- rat model of PD and relate to vocal production. In vitro, drugs, already identified via computational drug repurposing, will be applied to Pink1-/- neuron cell cultures. Corresponding molecular assays will be performed (IF, WB, PCR). 2. Using stereotaxic coordinates to perform a site-specific injection into vocal motor nuclei in the rat brain. 3. Piloting the effects of a TNF-a blocker in the rat model of PD. ____________________________________________________________________________ Role - Primary researcher ; IRB Status - N/A; Skills - We are able to train extensively on basic laboratory skills. Animal handling may be required. | Otolaryngology-Head and Neck Surgery | Treatments of vocal communication deficits in a Parkinson rat model | Parkinsons disease (PD) is the second most common age-related neurological disorder that dramatically affects health-related quality of life of the patient as well as places a substantial burden on caregivers and the healthcare system. As the current population ages, the prevalence is expected to double by 2030, affecting twice as many men as women. The hallmark of PD in the central nervous system is death of dopaminergic neurons in the substantia nigra which corresponds to the classic disease-associated movement disorders; however, in most cases, neuron death precedes clinical presentation of motor signs. The onset of the disease occurs at least a decade prior to diagnosis leaving a loss in therapeutic opportunity. Widespread sensorimotor deficits, including early-onset vocal communication impairments (e.g. dysphonia, dysarthria), impact 90% of individuals with PD. Despite a significant negative health impact, management of vocal dysfunction in PD is restricted by a disconnect between current treatments and an understanding of the underlying early disease pathology, resulting in a critical gap in knowledge that limits patient treatment. Additionally, there are no specific biomarkers test to diagnose PD. The primary objective of our lab’s current work is to identify early stage (prodromal) gene biomarkers and pathways linked to vocalization and that are involved in the early stages of disease. Our lab models early-stage vocal motor behavioral deficits using a phosphatase and tensin homolog (PTEN)-induced putative kinase 1 knockout (Pink1-/-) rat as well as rat neuron cell culture. Opportunities in the lab for summer 2023 include: 1. Drug repurposing and cell culture. Previously generated RNA-sequencing datasets have identified enriched genetic pathways and differentially expressed genes that are dysregulated in the Pink1-/- rat model of PD and relate to vocal production. In vitro, drugs, already identified via computational drug repurposing, will be applied to Pink1-/- neuron cell cultures. Corresponding molecular assays will be performed (IF, WB, PCR). 2. Using stereotaxic coordinates to perform a site-specific injection into vocal motor nuclei in the rat brain. 3. Piloting the effects of a TNF-a blocker in the rat model of PD. | 1 | Primary researcher | Some | We are able to train extensively on basic laboratory skills. Animal handling may be required. | N/A | Yes | Yes | Yes | UW undergraduates interested in research | No | No | David Barnett (dbarnett@wisc.edu), Sarah Lechner (slechner@wisc.edu) | Cynthia Kelm-Nelson, cakelm@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuep-Rvx023ZUEgvNYTZVHskMvJD7r1DR5e2HTSJMcWq292SqAWr2rZGe7kFeZsrXlo | ||||||||
| agepner@medicine.wisc.edu | Adam | Gepner | MD | Associate Professor of Medicine | 6.085.778.048 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Understanding blood pressure and hemodynamic assessments in older Veterans based on Hypertensive Status - FAST Vets Study.: The FAST-Vet study enrolled 180 Veterans over 60 years old with and without hypertension. Veterans underwent an arterial stress test where vascular parameters were measured before and after exercise (day 1) and sublingual nitroglycerin (day 2). Arterial stiffness and cardiovascular hemodynamics were obtained. We have several ongoing subaims that where a Shapiro Scholar could help test and analyze novel non-invasive diagnostics to personalize hypertension care in older adults. Our lab challenges the existing dogma that blood pressure are best measured at rest. Potential Specific Projects: 1. Evaluate differences between central and peripheral blood pressure with age and hypertension status. 2. Evaluate self-reported exercise status with actual maximum workload in older veterans with hypertension. 3. Evaluate differences and similarities between arterial stiffness parameters following exercise or nitroglycerin administration based on hypertension status. A scholar could use these skills to non-invasively improve diagnosis, treatment goals, and quality of life in an older at-risk adults. Website: https://www.medicine.wisc.edu/cardiovascular-medicine/gepner-research ____________________________________________________________________________ Role - A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevent topics. 2. Review and understand FAST-Vet protocol and study techniques. 3. Review and analyze data on a subaims of the FAST-Vets study (see projects ideas above). 4. Compose a research proposal/abstract/manuscript; IRB Status - Active; Skills - Some statistical and programming background is helpful but not required. | Cardiovascular Medicine | Understanding blood pressure and hemodynamic assessments in older Veterans based on Hypertensive Status - FAST Vets Study. | The FAST-Vet study enrolled 180 Veterans over 60 years old with and without hypertension. Veterans underwent an arterial stress test where vascular parameters were measured before and after exercise (day 1) and sublingual nitroglycerin (day 2). Arterial stiffness and cardiovascular hemodynamics were obtained. We have several ongoing subaims that where a Shapiro Scholar could help test and analyze novel non-invasive diagnostics to personalize hypertension care in older adults. Our lab challenges the existing dogma that blood pressure are best measured at rest. Potential Specific Projects: 1. Evaluate differences between central and peripheral blood pressure with age and hypertension status. 2. Evaluate self-reported exercise status with actual maximum workload in older veterans with hypertension. 3. Evaluate differences and similarities between arterial stiffness parameters following exercise or nitroglycerin administration based on hypertension status. A scholar could use these skills to non-invasively improve diagnosis, treatment goals, and quality of life in an older at-risk adults. Website: https://www.medicine.wisc.edu/cardiovascular-medicine/gepner-research | 1 | A Shapiro Scholar will be responsible for the following (with guidance and supervision): 1. Reviewing background material and collecting articles on relevent topics. 2. Review and understand FAST-Vet protocol and study techniques. 3. Review and analyze data on a subaims of the FAST-Vets study (see projects ideas above). 4. Compose a research proposal/abstract/manuscript | The scholar should be comfortable working independently and with our research team | Some statistical and programming background is helpful but not required. | Active | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | Amy Hein - Amy.Hein@va.gov | Adam Gepner, agepner@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufEkzqlo-47Fw2fu6G9kZFqKuaVT9YisF6f9TYn169ALH4pYZXCWB71EcRMGonrrLQ | ||||||||
| mralbert@wisc.edu | Mark | Albertini | MD | Professor | 608 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma: Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. Lab web site: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research ____________________________________________________________________________ Role - The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin. ; IRB Status - N/A; Skills - Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | Hematology/Medical Oncology/Palliative Care | Cindy Zuleger, PhD | clz@medicine.wisc.edu | Medicine | Hematology/Medical Oncology/Palliative Care | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma | Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. Lab web site: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research | 1 | The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin. | Ability to independently review the literature related to the research project is required. While mentoring is provided in the lab, progressing to independence with laboratory analyses is expected. | Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | N/A | VA Merit Grant | Plan to apply to the Dept of Medicine for stipend support or use the Dean's Office Funds. I do not have separate funding to cover 50% of the Shapiro summer student's stipend. | Yes | PhD students, UW undergraduates interested in research | No | No | Dr. Cindy Zuleger: clz@medicine.wisc.edu | Mark Albertini, mralbert@wisc.edu -- Co-Mentor: Cindy Zuleger, PhD clz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudVfqoyjvw8EQQ6CQN45M_iXwY3moBMj6NMX6dMUGyIVpjqGqeCAzLiAlkBrjl1FXQ | ||||
| mralbert@wisc.edu | Mark | Albertini | M.D. | Professor | 608 | Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PIG-A mutant T-cells as a biomarker of response to immune checkpoint blockade in metastatic melanoma: Melanoma-reactive T-cells are lymphocytes that have been stimulated in vivo by tumor antigens to undergo cell division. As mutation is expected to occur preferentially in dividing cells, a clonal assay that selects for T-cells with a specific in vivo mutation could enrich for T-cells that have undergone repetitive in vivo cell division. The Albertini lab has studied selection of T-cells with mutation acquired in vivo in a reporter gene (the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene) by in vivo harvesting of lymphocytes followed by clonal expansion in vitro in the presence of 6-thioguanine. Findings in melanoma patients demonstrate an increase in HPRT mutant frequency (MF) compared to normal controls. Despite the virtues of the HPRT mutation system, there are several deficiencies. Namely it is time consuming, expensive, and need for in vitro expansion. The phosphatidylinositol glycan class A (PIG-A) gene is one of four genes that code for the proteins constituting glucosamine acetyl (GlcNAc) transferase – a multimeric enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. PIG-A is located on the X-chromosome and therefore is hemizygous. Mutation in PIG-A gene results in a deficiency of surface expressions of all GPI-anchored proteins. A cloning assay for PIG-A mutant T-lymphocytes has been described, and it allows isolation of mutants for molecular and functional analyses without extensive cytokine-mediated growth in vitro and the manual scoring methods currently required for determination of HPRT mutant frequencies by cloning. The objective of this project is to validate and implement a rapid, fluorescence-activated cell sorter (FACS) based assay to quantitatively assess frequencies of somatic mutant T-cells (PIG-A mutants) in melanoma patients in vivo. Lab website: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research ____________________________________________________________________________ Role - The student will directly participate in the laboratory studies. The student will be trained in flow cytometry, sterile cell culture, and molecular assessment of T-cell receptor gene usage. In addition to the laboratory duties, the student will have involvement with melanoma patients on translational melanoma research studies ; IRB Status - This project is approved by the IRB.; Skills - Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | Hematology/Medical Oncology/Palliative Care | Cindy Zuleger | clz@medicine.wisc.edu | Medicine | Hematology/Medical Oncology/Palliative Care | PIG-A mutant T-cells as a biomarker of response to immune checkpoint blockade in metastatic melanoma | Melanoma-reactive T-cells are lymphocytes that have been stimulated in vivo by tumor antigens to undergo cell division. As mutation is expected to occur preferentially in dividing cells, a clonal assay that selects for T-cells with a specific in vivo mutation could enrich for T-cells that have undergone repetitive in vivo cell division. The Albertini lab has studied selection of T-cells with mutation acquired in vivo in a reporter gene (the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene) by in vivo harvesting of lymphocytes followed by clonal expansion in vitro in the presence of 6-thioguanine. Findings in melanoma patients demonstrate an increase in HPRT mutant frequency (MF) compared to normal controls. Despite the virtues of the HPRT mutation system, there are several deficiencies. Namely it is time consuming, expensive, and need for in vitro expansion. The phosphatidylinositol glycan class A (PIG-A) gene is one of four genes that code for the proteins constituting glucosamine acetyl (GlcNAc) transferase – a multimeric enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) anchor biosynthesis. PIG-A is located on the X-chromosome and therefore is hemizygous. Mutation in PIG-A gene results in a deficiency of surface expressions of all GPI-anchored proteins. A cloning assay for PIG-A mutant T-lymphocytes has been described, and it allows isolation of mutants for molecular and functional analyses without extensive cytokine-mediated growth in vitro and the manual scoring methods currently required for determination of HPRT mutant frequencies by cloning. The objective of this project is to validate and implement a rapid, fluorescence-activated cell sorter (FACS) based assay to quantitatively assess frequencies of somatic mutant T-cells (PIG-A mutants) in melanoma patients in vivo. Lab website: https://www9a.medicine.wisc.edu/hematology-oncology/albertini-research | 1 | The student will directly participate in the laboratory studies. The student will be trained in flow cytometry, sterile cell culture, and molecular assessment of T-cell receptor gene usage. In addition to the laboratory duties, the student will have involvement with melanoma patients on translational melanoma research studies | Ability to independently review the literature related to the research project is required. While mentoring is provided in the lab, progressing to independence with laboratory analyses is expected. | Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | This project is approved by the IRB. | VA Merit Grant and and a gift from Ann's Hope Foundation | Plan to apply to the Dept of Medicine for stipend support or use the Dean's Office Funds. I do not have separate funding to cover 50% of the Shapiro summer student's stipend. | Yes | PhD students, UW undergraduates interested in research | No | No | Dr. Cindy Zuleger: clz@medicine.wisc.edu | Mark Albertini, mralbert@wisc.edu -- Co-Mentor: Cindy Zuleger clz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuf4qujWALSnBKR-F0H-ZU0oAnZXdrRRSoDA4jpDjnQPMy5pdGnCePyo22aPf6yt_6o | ||||
| spiker@ortho.wisc.edu | Andrea | Spiker | MD | Assistant Professor, Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Manipulation Under Anesthesia after Hip Arthroscopy for Pericapsular Scarring: Patient Outcomes: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and a subsequent manipulation under anesthesia for peri-capsular scarring. This is a new technique, for which we have submitted a techniques paper which is now under review for publication, and we want to publish our results after this procedure is performed. We will focus on patient reported outcome measures and improvements in range of motion after the technique. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our registry and for this project under the IRB umbrella protocol; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Manipulation Under Anesthesia after Hip Arthroscopy for Pericapsular Scarring: Patient Outcomes | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and a subsequent manipulation under anesthesia for peri-capsular scarring. This is a new technique, for which we have submitted a techniques paper which is now under review for publication, and we want to publish our results after this procedure is performed. We will focus on patient reported outcome measures and improvements in range of motion after the technique. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our registry and for this project under the IRB umbrella protocol | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudEheSW1YJhWrXTkvGC_rtYXaBvWoMfOggN60peJuH-7dcDeJ5miajwIUaDT4Arqtw | ||||||||
| spiker@ortho.wisc.edu | Andrea | Spiker | MD | Assistant Professor, Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Sports Medicine Performance Research: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry as well as functional testing data obtained by our UW Sports Medicine physical therapy group. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project for this student is threefold: 1) entering patient data into the Hip Registry (along with other Shapiro students working with the lead PI) 2) setting up logistical details of a funded, prospective study which will involve Badger athletes and pre-season imaging of the hip which will begin in the fall of 2023 (after the Shapiro summer) and 3) performing a retrospective review of the physical therapy functional testing performed after ACL reconstruction to answer specific questions about return to sport after ACL reconstruction. The goal would be for the Shapiro student to be a co-author on the manuscript for the third portion of the project involving ACL functional testing as well as other projects that he/she will assist with during the course of the summer. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval for our hip preservation registry is under an IRB umbrella protocol; IRB exemption expected for the ACL functional testing ; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Sports Medicine | Geoff Baer | baer@ortho.wisc.edu | Orthopedics and Rehabilitation | Sports Medicine | Sports Medicine Performance Research | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry as well as functional testing data obtained by our UW Sports Medicine physical therapy group. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project for this student is threefold: 1) entering patient data into the Hip Registry (along with other Shapiro students working with the lead PI) 2) setting up logistical details of a funded, prospective study which will involve Badger athletes and pre-season imaging of the hip which will begin in the fall of 2023 (after the Shapiro summer) and 3) performing a retrospective review of the physical therapy functional testing performed after ACL reconstruction to answer specific questions about return to sport after ACL reconstruction. The goal would be for the Shapiro student to be a co-author on the manuscript for the third portion of the project involving ACL functional testing as well as other projects that he/she will assist with during the course of the summer. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval for our hip preservation registry is under an IRB umbrella protocol; IRB exemption expected for the ACL functional testing | No | Yes | Yes | Not currently available to mentor other students | Unsure / Depends | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Amie Armstrong (armstrong@ortho.wisc.edu) Hip Preservation Research Coordinator | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Geoff Baer baer@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufWs8JjTk7RZmYcGSlH-oW4yKRgpG1F7MSoFNlpfNDQJYjX2XPkAV55d--L7vwBwns | ||||
| dshirley@medicine.wisc.edu | Dan | Shirley | MD, MS | Assistant Professor | Medicine | Shorter term projects | Barriers to Infection Control in Kigali, Rwanda: Perform qualitative analysis of infection control practices at King Faisal Hospital in Kigali, Rwanda using the Systems Engineering Initiative for Patient Safety (SIEPS) model. Conduct semi-structured interviews of hospital employees. Transcribe interviews, ode for themes, and analyze. Report the barriers and facilitators to infection control. The project may focus on infection control in general, hang hygiene practices, and/or surgical site infection. ____________________________________________________________________________ Role - Data collection, data analysis, manuscript preparation; IRB Status - In progress; Skills - familiarity with qualitative research collection or analysis would be helpful | Infectious Disease | Dawd Siraj, MD, MPH&TM, Professor | dssiraj@medicine.wisc.edu | Medicine | Infectious Diseases | Barriers to Infection Control in Kigali, Rwanda | Perform qualitative analysis of infection control practices at King Faisal Hospital in Kigali, Rwanda using the Systems Engineering Initiative for Patient Safety (SIEPS) model. Conduct semi-structured interviews of hospital employees. Transcribe interviews, ode for themes, and analyze. Report the barriers and facilitators to infection control. The project may focus on infection control in general, hang hygiene practices, and/or surgical site infection. | 1 | Data collection, data analysis, manuscript preparation | Moderate to high (mentors are available for research; independent travel to Rwanda) | familiarity with qualitative research collection or analysis would be helpful | In progress | No | No (plan to use Dean's Office Funds) | Yes | MPH students | No | Yes | acmapes@medicine.wisc.edu | Dan Shirley, dshirley@medicine.wisc.edu -- Co-Mentor: Dawd Siraj, MD, MPH&TM, Professor dssiraj@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuds4P0OoCkAINng4B0iszagV_Qu0AvhjDw7hU3rLjwYMYCTe88x9uHWnY46GWqeYLI | |||||
| dssiraj@medicine.wisc.edu | Dawd | Siraj | MD, MPH&TM | Professor | Medicine | Shorter term projects | Bacterial Culture and Antimicrobial Resistance Patterns in Rwanda: To identify the organisms responsible for bacterial infections at King Faisal Hospital (KFH) in Kigali, Rwanda, determine susceptibility patterns, and estimate the likelihood of successful treatment of these organisms based on empiric antibiotic use for different types of infection. This is a retrospective analysis of bacterial isolates and resistance patterns at King Faisal Hospital. Blood, urine, wound, CSF, and respiratory culture results will be obtained by review of 5 years’ worth of the Microbiology laboratory data (electronic). The data recorded from each positive culture will include date of collection, body source, hospital unit/site of collection, organism identification, antimicrobial susceptibilities and minimum inhibitory concentrations (MICs). We estimate that the sample size will be approximately 1000 isolates. Once collected, we will calculate and analyze the most common organisms responsible for different infections and determine rates of resistance to common antibiotics. This will be presented as a basic antibiogram. Link to research page: https://www.medicine.wisc.edu/infectious-disease/siraj-research ____________________________________________________________________________ Role - Data collection, data analysis, manuscript preparation; IRB Status - In progress; Skills - attention to detail for data collection | Infectious Disease | Dan Shirley, MD, MS, Assistant Professor | dshirley@medicine.wisc.edu | Medicine | Infectious Disease | Bacterial Culture and Antimicrobial Resistance Patterns in Rwanda | To identify the organisms responsible for bacterial infections at King Faisal Hospital (KFH) in Kigali, Rwanda, determine susceptibility patterns, and estimate the likelihood of successful treatment of these organisms based on empiric antibiotic use for different types of infection. This is a retrospective analysis of bacterial isolates and resistance patterns at King Faisal Hospital. Blood, urine, wound, CSF, and respiratory culture results will be obtained by review of 5 years’ worth of the Microbiology laboratory data (electronic). The data recorded from each positive culture will include date of collection, body source, hospital unit/site of collection, organism identification, antimicrobial susceptibilities and minimum inhibitory concentrations (MICs). We estimate that the sample size will be approximately 1000 isolates. Once collected, we will calculate and analyze the most common organisms responsible for different infections and determine rates of resistance to common antibiotics. This will be presented as a basic antibiogram. Link to research page: https://www.medicine.wisc.edu/infectious-disease/siraj-research | 0 | Data collection, data analysis, manuscript preparation | Moderate to high (mentors are available for research; independent travel to Rwanda) | attention to detail for data collection | In progress | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Yes | acmapes@medicine.wisc.edu | Dawd Siraj, dssiraj@medicine.wisc.edu -- Co-Mentor: Dan Shirley, MD, MS, Assistant Professor dshirley@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuc2w41oqkbxWRVLQ-12djO9CntcwjeMdP71_Jeiq-s2lq2ig3CIE1ekbz7B479lwpw | |||||
| jpholt@medicine.wisc.edu | Joe | Holt | MD | Director, WARM | Academic Affairs | Not currently interested or available for Non-Shapiro research mentoring of medical students | The WARM Paper: o The goal of the WARM paper is to complete a retrospective review of WARM graduation statistics, and success in placement of physicians serving rural Wisconsin. The paper may explore comparisons to other baseline rural and traditional programs. o Students will work closely with WARM faculty and staff, and will gain knowledge and skills that are relevant to administrative roles in academic medicine. o Students can expect to interface with other rural programs in medical schools retrieving benchmark data from those programs and will pursue literature review seeking additional rural data. o Project should result in future opportunities for presentations, posters, and publication. o Length of project period is flexible and could be tailored to student interest. The project could be completed by a single student, or multiple students in collaboration. o Two spots are available, priority given to current WARM students. ____________________________________________________________________________ Role - Collaborate with WARM administrative leaders to create, prepare, and submit results for abstract/publication.; IRB Status - N/a; Skills - Data review, literature review, academic writing, communication skills allowing collaboration with other medical schools, and rural medicine leaders. | Medical Education Office | Kenny MacMillan | kmacmillan@wisc.edu | Academic Affairs | The WARM Paper | o The goal of the WARM paper is to complete a retrospective review of WARM graduation statistics, and success in placement of physicians serving rural Wisconsin. The paper may explore comparisons to other baseline rural and traditional programs. o Students will work closely with WARM faculty and staff, and will gain knowledge and skills that are relevant to administrative roles in academic medicine. o Students can expect to interface with other rural programs in medical schools retrieving benchmark data from those programs and will pursue literature review seeking additional rural data. o Project should result in future opportunities for presentations, posters, and publication. o Length of project period is flexible and could be tailored to student interest. The project could be completed by a single student, or multiple students in collaboration. o Two spots are available, priority given to current WARM students. | 2 | Collaborate with WARM administrative leaders to create, prepare, and submit results for abstract/publication. | Data review, literature review, academic writing, communication skills allowing collaboration with other medical schools, and rural medicine leaders. | N/a | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | Yes | Joe Holt, jpholt@medicine.wisc.edu; Kenny MacMillan, kmacmillan@wisc.edu | Joe Holt, jpholt@medicine.wisc.edu -- Co-Mentor: Kenny MacMillan kmacmillan@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnue5w0pXS6D0gAjxZ94sBtlT8KX0mYKNWCtvt2Oq-q9yprOLN7kR_6Wcpgn2Cgdh3ZM | |||||||
| baschnagel@humonc.wisc.edu | Andrew | Baschnagel | M.D. | Associate Professor | 6.082.629.169 | Human Oncology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Outcomes and toxicity of patients treated with stereotactic radiation for non-small cell lung cancer in the setting of pulmonary fibrosis.: This is a retrospective analysis of patients with pulmonary fibrosis and early stage lung cancer treated with stereotactic body radiation. The goal of this research is to evaluate toxicity in these high risk patients. Very little has been reported on the safety of SBRT in patients with ILD. The work includes using the SBRT database to identify patients with pulmonary fibrosis and then to review their outcomes in Healthlink. In addition, we will explore the utility of radiomics and 4DCT ventilation to assess pulmonary function at time of treatment. The student will gain knowledge about non-small cell lung cancer, radiotherapy, and pulmonary fibrosis. Opportunity to learn statistics and learn about radiomics. There is also opportunity to submit the work as an abstract and/or publication. Previous Students who have worked with me have had the opportunity to publish their work. This project is perfect for someone interested in radiation oncology or medical oncology or radiology or pulmonary or thoracic surgery. ____________________________________________________________________________ Role - The student's role will be to review patients charts and enter data into a database. The student will be responsible for organizing and analyzing the data and will work with the team to perform statistical analyses.; IRB Status - approved; Skills - basic data entry level skills. | Outcomes and toxicity of patients treated with stereotactic radiation for non-small cell lung cancer in the setting of pulmonary fibrosis. | This is a retrospective analysis of patients with pulmonary fibrosis and early stage lung cancer treated with stereotactic body radiation. The goal of this research is to evaluate toxicity in these high risk patients. Very little has been reported on the safety of SBRT in patients with ILD. The work includes using the SBRT database to identify patients with pulmonary fibrosis and then to review their outcomes in Healthlink. In addition, we will explore the utility of radiomics and 4DCT ventilation to assess pulmonary function at time of treatment. The student will gain knowledge about non-small cell lung cancer, radiotherapy, and pulmonary fibrosis. Opportunity to learn statistics and learn about radiomics. There is also opportunity to submit the work as an abstract and/or publication. Previous Students who have worked with me have had the opportunity to publish their work. This project is perfect for someone interested in radiation oncology or medical oncology or radiology or pulmonary or thoracic surgery. | 1 | The student's role will be to review patients charts and enter data into a database. The student will be responsible for organizing and analyzing the data and will work with the team to perform statistical analyses. | The work mainly involves going through patient's charts and so this can be done virtually. | basic data entry level skills. | approved | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | No | Ranee M. Williams-Toycen - williams@humonc.wisc.edu and Karen K Steiner - ksteiner@humonc.wisc.edu | Andrew Baschnagel, baschnagel@humonc.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnud3H3Z7XgjIief7NslBRHaNp1WFyN6l3nHLUzscqZs9QFz0GIdtPgYAZ8_LwD5jEvQ | |||||||||
| nkumar39@wisc.edu | Nilay | Kumar | MD | Assistant Professor | 2.055.401.971 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Racial-ethnic and socioeconomic disparities in outcomes of COVID-19 hospitalizations: This project will use the 2020 National Inpatient Sample database to examine the impact of race and socioeconomic status on outcomes of COVID hospitalization. We will use ICD-10 codes to identify patients with a principal discharge diagnosis of COVID. Using the race and ZIP code income quartile variable (surrogate for SES), we will examine the effects of these variables on in-hospital resource use and mortality after adjusting for relevant confounding variables. We will present the results as an abstract at local/national meetings and potentially submit for publication. ____________________________________________________________________________ Role - Prepare abstract for presentation, write up results in a paper for publication ; IRB Status - N/A ; Skills - Be prepared to read about basic statistics to understand the results. | Hospital Medicine | Racial-ethnic and socioeconomic disparities in outcomes of COVID-19 hospitalizations | This project will use the 2020 National Inpatient Sample database to examine the impact of race and socioeconomic status on outcomes of COVID hospitalization. We will use ICD-10 codes to identify patients with a principal discharge diagnosis of COVID. Using the race and ZIP code income quartile variable (surrogate for SES), we will examine the effects of these variables on in-hospital resource use and mortality after adjusting for relevant confounding variables. We will present the results as an abstract at local/national meetings and potentially submit for publication. | 0 | Prepare abstract for presentation, write up results in a paper for publication | Minimal independence required. I will analyze the data and provide guidance on writing abstract and manuscript. | Be prepared to read about basic statistics to understand the results. | N/A | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | No | Yes | N/A | Nilay Kumar, nkumar39@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucAYMxKJHorGavcVoBIciZdLa4BVDsaUYq7CT1vI_CwVqeIzL91p8GQP4zDUnqGhmg | ||||||||
| nkumar39@wisc.edu | Nilay | Kumar | MD | Assistant Professor | 2.055.401.971 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Prevalence, predictors, and prognosis associated with thrombotic events among patients hospitalized for COVID-19: Using the 2020 National Inpatient Sample, we will identify patients with a primary or secondary diagnosis of COVID-19 using ICD-10 codes. Further we will identify patients with documented discharge diagnoses of thrombotic events (DVT/PE, ACS, stroke). We will examine variables associated with thrombotic illness using multivariate logistic regression models. Subsequently, we will use adjusted models to examine the effect of thrombotic episodes on in-hospital mortality among patients hospitalized for COVID-19. ____________________________________________________________________________ Role - Understanding/interpreting analyzed data, writing abstract and paper. ; IRB Status - n/a ; Skills - understanding basics statistics (can be learned during the course of this project), writing | Prevalence, predictors, and prognosis associated with thrombotic events among patients hospitalized for COVID-19 | Using the 2020 National Inpatient Sample, we will identify patients with a primary or secondary diagnosis of COVID-19 using ICD-10 codes. Further we will identify patients with documented discharge diagnoses of thrombotic events (DVT/PE, ACS, stroke). We will examine variables associated with thrombotic illness using multivariate logistic regression models. Subsequently, we will use adjusted models to examine the effect of thrombotic episodes on in-hospital mortality among patients hospitalized for COVID-19. | 1 | Understanding/interpreting analyzed data, writing abstract and paper. | Minimal independence required. | understanding basics statistics (can be learned during the course of this project), writing | n/a | No | No (plan to use Dean's Office Funds) | Yes | UW undergraduates interested in research | No | Yes | n/a | Nilay Kumar, nkumar39@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufYzLUidLRNuD-jOslMbJFkTCkzDngGc_Nd34IakzG6StiRrd7Uym14bMN_ZXLoRDk | |||||||||
| jenett@medicine.wisc.edu | Jeniel | Nett | MD PhD | Associate Professor | 608 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Mechanisms of Candida auris skin colonization: Candida auris colonizes the skin of patients and spreads person-to-person in healthcare facilities. We found that C. auris proliferates in the skin environment and forms biofilms. This project is examining mechanisms of pathogenicity for C. auris skin colonization. A Shapiro student would grow wildtype and mutant C. auris biofilms and examine phenotypes. ____________________________________________________________________________ Role - This is a bench work opportunity.; IRB Status - N/A; Skills - None | Infectious Diseases | Medical Microbiology & Immunology | Mechanisms of Candida auris skin colonization | Candida auris colonizes the skin of patients and spreads person-to-person in healthcare facilities. We found that C. auris proliferates in the skin environment and forms biofilms. This project is examining mechanisms of pathogenicity for C. auris skin colonization. A Shapiro student would grow wildtype and mutant C. auris biofilms and examine phenotypes. | 1 | This is a bench work opportunity. | The student would be trained on experiments and could progress to independence as comfortable | None | N/A | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Unsure / Depends | N/A | Jeniel Nett, jenett@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucyw157gGA50CAWMtDIR9AY9oPX6lS7QiwM27gIj78H-ZPgEWWm_V-EjnlvztHiBTw | |||||||
| mschweizer@medicine.wisc.edu | Marin | Schweizer | PhD | (Visiting) Professor | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Meta-Analysis on Benefits of De-implementing Unnecessary Clinical Tests: The Choosing Wisely initiative found that many medical tests (e.g., urine cultures among patients without UTI symptoms) and treatments are of low value and may lead to adverse patient events (e.g., side effects from unnecessary antibiotics). “De-implementation” uses methodology from the field of implementation science to encourage providers to stop prescribing low value tests and treatments. Our Shapiro student will choose a test and/or treatment from the Infectious Diseases Society of America (www.choosingwisely.org/societies/infectious-diseases-society-of-america/) or Society for Healthcare Epidemiology of America (www.choosingwisely.org/societies/society-for-healthcare-epidemiology-of-america/) Choosing Wisely lists to assess the impact of de-implementing this test or treatment. The Shapiro student will perform a systematic literature review and meta-analysis of de-implementation studies to evaluate the benefits of de-implementation of this test and/or treatment. Our hypothesis is that de-implementation will lead to benefits such as cost savings, reduced rates of C. difficile infections, and reduced patient adverse events. Dr. Schweizer is an expert in de-implementation and meta-analysis. A prior summer medical student published her meta-analysis that she performed with Dr. Schweizer: Feazel et al., J Antimicrob Chemother. 2014;69(7):1748-54. ____________________________________________________________________________ Role - Perform systematic literature review and meta-analysis; IRB Status - N/A; Skills - Basic understanding of statistics or willingness to learn. | Infectious Diseases | Meta-Analysis on Benefits of De-implementing Unnecessary Clinical Tests | The Choosing Wisely initiative found that many medical tests (e.g., urine cultures among patients without UTI symptoms) and treatments are of low value and may lead to adverse patient events (e.g., side effects from unnecessary antibiotics). “De-implementation” uses methodology from the field of implementation science to encourage providers to stop prescribing low value tests and treatments. Our Shapiro student will choose a test and/or treatment from the Infectious Diseases Society of America (www.choosingwisely.org/societies/infectious-diseases-society-of-america/) or Society for Healthcare Epidemiology of America (www.choosingwisely.org/societies/society-for-healthcare-epidemiology-of-america/) Choosing Wisely lists to assess the impact of de-implementing this test or treatment. The Shapiro student will perform a systematic literature review and meta-analysis of de-implementation studies to evaluate the benefits of de-implementation of this test and/or treatment. Our hypothesis is that de-implementation will lead to benefits such as cost savings, reduced rates of C. difficile infections, and reduced patient adverse events. Dr. Schweizer is an expert in de-implementation and meta-analysis. A prior summer medical student published her meta-analysis that she performed with Dr. Schweizer: Feazel et al., J Antimicrob Chemother. 2014;69(7):1748-54. | 1 | Perform systematic literature review and meta-analysis | None. | Basic understanding of statistics or willingness to learn. | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | Yes | N/A | Marin Schweizer, mschweizer@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucbFhQLwiyPB3PMkNmIJ7N2wuzyyvqXjXeuooG5I19-4w7hn3iHeJdkrWAtDF8tcc8 | |||||||||
| szafar2@wisc.edu | S. Nabeel | Zafar | MD MPH | Assistant Professor of Surgery | 4.104.467.225 | Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | The Global Burden of Cancer - Using a DataScience approach to measure global disparity and avoidable death and disability: This is a novel project that will involve looking at cancer data from 185 countries around the world for 33 cancer subtypes and developing a Metric than can better depict the disparities in cancer outcomes around the world as well as measure the how much of cancer related death and disability is avoidable. The student will learn to understand 'burden of disease' measures, how to find these and use them for analysis. The student will learn about cancer around the world and the disparities in cancer care and outcomes. The student will learn about using country meta-data such as income, life-expectancy, literacy rates etc. and how they can be used to assess for disparity in healthcare. While this project focuses on a larger -global perspective, the student also has the opportunity to take a deeper dive in to one country of their choosing and interest and write a primary author manuscript on it. ____________________________________________________________________________ Role - The student will extract data from publicly available sources and the literature. will be expected to establish and maintain a dataset, partake in analysis and presentation of results. The student will expected to write parts of the manuscript. Other than meeting requirements of the Shapiro program. The student has the opportunity and is preferred to submit at least one abstract submission to a regional/national meeting and be co-author on at least one publication. The student will be expected to attend department of surgery programing related to research methods.; IRB Status - N/A; Skills - An intelligent and curious mind. Dedicated to research and pays attention to detail. | Surgical Oncology | The Global Burden of Cancer - Using a DataScience approach to measure global disparity and avoidable death and disability | This is a novel project that will involve looking at cancer data from 185 countries around the world for 33 cancer subtypes and developing a Metric than can better depict the disparities in cancer outcomes around the world as well as measure the how much of cancer related death and disability is avoidable. The student will learn to understand 'burden of disease' measures, how to find these and use them for analysis. The student will learn about cancer around the world and the disparities in cancer care and outcomes. The student will learn about using country meta-data such as income, life-expectancy, literacy rates etc. and how they can be used to assess for disparity in healthcare. While this project focuses on a larger -global perspective, the student also has the opportunity to take a deeper dive in to one country of their choosing and interest and write a primary author manuscript on it. | 1 | The student will extract data from publicly available sources and the literature. will be expected to establish and maintain a dataset, partake in analysis and presentation of results. The student will expected to write parts of the manuscript. Other than meeting requirements of the Shapiro program. The student has the opportunity and is preferred to submit at least one abstract submission to a regional/national meeting and be co-author on at least one publication. The student will be expected to attend department of surgery programing related to research methods. | partial independence. will be supervised by myself and other members of the lab | An intelligent and curious mind. Dedicated to research and pays attention to detail. | N/A | Yes | Through the department of surgery | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | Sarah Pavao | S. Nabeel Zafar, szafar2@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueaZRTn_x2o4NdnW9Giip6F8eFXG3or7HmIvAn9ib0wEX_dPlnqHJd1i8_XMfweDlc | ||||||||
| emonroe@uwhealth.org | Eric | Monroe | M.D. | Associate Professor | 414 | Radiology | Not currently interested or available for Non-Shapiro research mentoring of medical students, Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Pediatric Interventional Radiology Clinical Program Development: In 2021, the Department of Radiology launched a dedicated Pediatric Interventional Radiology program as an extension of both Pediatric Radiology and Interventional Radiology sections. The first 18-24 months of program development has created multiple retrospective/descriptive subprojects listed below. The opportunity is best suited for students with interests in interventional radiology, clinical program development and healthcare economics who are looking to build their experience and resumes via multiple brief but impactful abstracts and manuscripts. Potential subprojects are as follows: - Clinical practice impact of adding first dedicated pediatric interventional radiologist to an academic group covering an adjoined tertiary children’s hospital (procedure turnaround time, case growth, pediatric contribution to after hours volume, etc). - Results of a nurse-driven vascular access team expanded to pediatric PICC coverage (volumes, turnaround time, reduced burden on IR program, clinical outcomes, etc). - Results of integrating a handheld cordless US into IR consultation and procedures (time to determination of procedural feasibility, US exam charge capture, device performance in a procedural environment). - Time-driven cost analysis of pediatric IR procedures occurring in different procedural environments, specifically Pediatric IR suite versus Pediatric Sedation Clinic versus Operating Room. - Impact of canine participation in periprocedural Child Life services (patient/family satisfaction, sedation and procedural outcomes). ____________________________________________________________________________ Role - First author; IRB Status - IRB will be completed ahead of project start date, depending on student's interest in subprojects listed; Skills - Manuscript composition, basic data analysis, human research subjects training (HIPAA, etc) | Pediatric Interventional Radiology | Jonathan Swanson | jswanson@uwhealth.org | Radiology | Pediatric Radiology | Pediatric Interventional Radiology Clinical Program Development | In 2021, the Department of Radiology launched a dedicated Pediatric Interventional Radiology program as an extension of both Pediatric Radiology and Interventional Radiology sections. The first 18-24 months of program development has created multiple retrospective/descriptive subprojects listed below. The opportunity is best suited for students with interests in interventional radiology, clinical program development and healthcare economics who are looking to build their experience and resumes via multiple brief but impactful abstracts and manuscripts. Potential subprojects are as follows: - Clinical practice impact of adding first dedicated pediatric interventional radiologist to an academic group covering an adjoined tertiary children’s hospital (procedure turnaround time, case growth, pediatric contribution to after hours volume, etc). - Results of a nurse-driven vascular access team expanded to pediatric PICC coverage (volumes, turnaround time, reduced burden on IR program, clinical outcomes, etc). - Results of integrating a handheld cordless US into IR consultation and procedures (time to determination of procedural feasibility, US exam charge capture, device performance in a procedural environment). - Time-driven cost analysis of pediatric IR procedures occurring in different procedural environments, specifically Pediatric IR suite versus Pediatric Sedation Clinic versus Operating Room. - Impact of canine participation in periprocedural Child Life services (patient/family satisfaction, sedation and procedural outcomes). | 2 | First author | Moderate | Manuscript composition, basic data analysis, human research subjects training (HIPAA, etc) | IRB will be completed ahead of project start date, depending on student's interest in subprojects listed | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Unsure / Depends | Unsure / Depends | N/A | Eric Monroe, emonroe@uwhealth.org -- Co-Mentor: Jonathan Swanson jswanson@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnue_f0jSng-EmS8DeR_FKZfonRr2kGKL4y3iBA6Ki94jYZfhAq4yKjisX5hFA9O9q2Y | ||||
| emonroe@uwhealth.org | Eric | Monroe | M.D. | Associate Professor | 414 | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Time-Driven Cost Analysis of Nonoperative Diagnosis of Biliary Atresia: Biliary atresia is a common cause of cholestatic jaundice in infants, and requires prompt diagnosis and surgical correction to avoid permanent liver failure and need for transplant. The gold standard method of confirmation is operative cholangiography. Traditionally, cholescintigraphy has been the first diagnostic test of choice but false positive rates may lead to high rates of negative laparatomy. For cases that are indeterminate on cholescintigraphy, liver biopsy combined with percutaneous cholecystocholangiography is effective at excluding biliary atresia. Within the institution, patients have undergone heterogenous pathways for the diagnosis or exclusion of biliary atresia, creating opportunities for comparative assessment. A retrospective time-driven cost analysis will be used to model the economic implications of each approach and inform future institutional approach as well as published consensus guidelines. ____________________________________________________________________________ Role - First author; data acquisition and assessment, manuscript preparation; IRB Status - IRB will be prepared by PI in anticipation of student participation; Skills - Manuscript composition, basic data analysis and statistics, human resource subjection training | Pediatric Interventional Radiology | Jonathan | Swanson | Radiology | Pediatric Radiology | Time-Driven Cost Analysis of Nonoperative Diagnosis of Biliary Atresia | Biliary atresia is a common cause of cholestatic jaundice in infants, and requires prompt diagnosis and surgical correction to avoid permanent liver failure and need for transplant. The gold standard method of confirmation is operative cholangiography. Traditionally, cholescintigraphy has been the first diagnostic test of choice but false positive rates may lead to high rates of negative laparatomy. For cases that are indeterminate on cholescintigraphy, liver biopsy combined with percutaneous cholecystocholangiography is effective at excluding biliary atresia. Within the institution, patients have undergone heterogenous pathways for the diagnosis or exclusion of biliary atresia, creating opportunities for comparative assessment. A retrospective time-driven cost analysis will be used to model the economic implications of each approach and inform future institutional approach as well as published consensus guidelines. | 1 | First author; data acquisition and assessment, manuscript preparation | Manuscript composition, basic data analysis and statistics, human resource subjection training | IRB will be prepared by PI in anticipation of student participation | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Unsure / Depends | N/A | Eric Monroe, emonroe@uwhealth.org -- Co-Mentor: Jonathan Swanson | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucBkDYDSluFx7Y3v8EFU1zV9kKtz5cyFn5gwaJoKSlmg7Gayehe0yA4MlnsZ80-AJs | |||||
| hikuttab@medicine.wisc.edu | Hani | Kuttab | MD | Assistant Professor. Assistant Ultrasound Director | 0 | Emergency Medicine | Shorter term projects | Review of Applications of Point-of-Care Ultrasound on UW Med Flight: The goal of this project is to summarize the use of point-of-care ultrasound (POCUS) on UW Med Flight and explore the effect of ultrasound on patient management. Specifically, our primary aims are: 1) measure what point-of-care ultrasound examinations are performed on UW Med Flight, and 2) observe if POCUS examinations on patient management (as self-reported by Med Flight providers). Secondary aims are: 1) evaluate the image quality scores to further demonstrate feasibility in helicopter EMS setting, and 2) determine specifically how ultrasound altered patient management. ____________________________________________________________________________ Role - Pulling data from patient charts (e.g., age, demographics, medical history, etc.) Work with biostatistics colleagues to run an agreement analysis. Summarize findings and write/submit a manuscript to Air Medical Journal.; IRB Status - Completed; Skills - HealthLink Access. Knowledge of statistics is helpful but not necessary. | Ultrasound | Review of Applications of Point-of-Care Ultrasound on UW Med Flight | The goal of this project is to summarize the use of point-of-care ultrasound (POCUS) on UW Med Flight and explore the effect of ultrasound on patient management. Specifically, our primary aims are: 1) measure what point-of-care ultrasound examinations are performed on UW Med Flight, and 2) observe if POCUS examinations on patient management (as self-reported by Med Flight providers). Secondary aims are: 1) evaluate the image quality scores to further demonstrate feasibility in helicopter EMS setting, and 2) determine specifically how ultrasound altered patient management. | 0 | Pulling data from patient charts (e.g., age, demographics, medical history, etc.) Work with biostatistics colleagues to run an agreement analysis. Summarize findings and write/submit a manuscript to Air Medical Journal. | HealthLink Access. Knowledge of statistics is helpful but not necessary. | Completed | No | Yes | Yes | Not currently available to mentor other students | No | No | Hani I. Kuttab. Andrea Gilmore-Bykovskyi. | Hani Kuttab, hikuttab@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudWjVaYkyahKIlKpvmTO1IwpUQBudVOztmY2cWCsFiVp9EZU4svuodLWTkZuDfNNt4 | |||||||||
| bernardoni@medicine.wisc.edu | Brittney | Bernardoni | MD | Assistant Medical Director Quality, Med Flight Assistant Professor (CHS) Emergency Medicine & Anesthesiology | 6.307.072.403 | Emergency Medicine | Shorter term projects | Med Flight Pre-hospital Ventilator Management and Documentation : A significant number of patients transported by Med Flight require mechanical ventilation. The use of lung-protective ventilation is associated with improved outcomes in intubated patients. Currently, there is no standard protocol for documenting or adjusting ventilator settings of patients transported by Med Flight. The goal of this project is to identify what ventilator settings are currently documented and the proportion of patients with lung-protective strategies. Once completed, this work will lead to the development of a quality improvement initiative to optimize pre-hospital patient care. ____________________________________________________________________________ Role - Pulling data from pre-hospital chart, work with mentor to develop specific question(s)/metric(s) of interest to student, design analysis plan in conjunction with mentor/biostatisics personnel, write/submit to national conference or journal (helicopter emergency medical services (HEMS), emergency medicine, quality, or critical care depending on interest/project goal chosen). Option for involvement in development of QI initiative if interested. ; IRB Status - This project has been deemed IRB exempt via the IRB QI/Program Evaluation Self-Certification Tool ; Skills - None required, will mentor. Engaged and willing to learn/work hard towards completion of meaningful research. | Critical Care | Anesthesiology | Critical Care | Med Flight Pre-hospital Ventilator Management and Documentation | A significant number of patients transported by Med Flight require mechanical ventilation. The use of lung-protective ventilation is associated with improved outcomes in intubated patients. Currently, there is no standard protocol for documenting or adjusting ventilator settings of patients transported by Med Flight. The goal of this project is to identify what ventilator settings are currently documented and the proportion of patients with lung-protective strategies. Once completed, this work will lead to the development of a quality improvement initiative to optimize pre-hospital patient care. | 0 | Pulling data from pre-hospital chart, work with mentor to develop specific question(s)/metric(s) of interest to student, design analysis plan in conjunction with mentor/biostatisics personnel, write/submit to national conference or journal (helicopter emergency medical services (HEMS), emergency medicine, quality, or critical care depending on interest/project goal chosen). Option for involvement in development of QI initiative if interested. | None required, will mentor. Engaged and willing to learn/work hard towards completion of meaningful research. | This project has been deemed IRB exempt via the IRB QI/Program Evaluation Self-Certification Tool | No | Yes | Yes | Not currently available to mentor other students | Yes | Yes | Phoebe Natzke, pnatzke@medicine.wisc.edu; Andrea Gilmore-Bykovskyi, algilmore@medicine.wisc.edu | Brittney Bernardoni, bernardoni@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnue9QMnyustBv8JdG7kiDUJqVXgozaMm-ef7qatAg8tPutUytcBGN8BHV1HCPOdqa_Y | |||||||
| Sehgal@rehab.wisc.edu | Nalini | Sehgal | MD | Efficacy of Thoracic Radiofrequency Ablation | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Efficacy of Thoracic Radiofrequency Ablation: This is a retrospective study performed in collaboration with the Mayo Clinic on the efficacy of thoracic radiofrequency ablation. Thoracic spine pain related to arthropathy of the zygophophyseal joint (Z-joint), is challenging to treat. Work up often involves short-lived diagnostic and therapeutic anesthetic blocks to the medial branch of the dorsal ramus, which innervates the pain-generating Z-joint. Current procedure requires patients to have significant pain relief on 2 subsequent medial branch blocks (MBB) to confirm the diagnosis and nerve target in order to progress to a radiofrequency ablation (RFA), a procedure in which the medial branch is ablated for longstanding pain relief. Unlike RFA in the lumbar levels, the efficacy of RFA in the thoracic levels has not been well described. We believe that this may be due to the unique neuroanatomy in the thoracic spine and the overall paucity of data. We hypothesize that thoracic RFA is not effective, particularly in the mid-thoracic levels, when compared to lumbar RFA data. Modification of the thoracic RFA procedure may be necessary to accomodate the unique neuroanatomy of this region. ____________________________________________________________________________ Role - Chart review for data collection and analysis. Opportunities for article writing and presentation.; IRB Status - IRB approved; Skills - Prior experience with data collection/analysis and writing. | Efficacy of Thoracic Radiofrequency Ablation | This is a retrospective study performed in collaboration with the Mayo Clinic on the efficacy of thoracic radiofrequency ablation. Thoracic spine pain related to arthropathy of the zygophophyseal joint (Z-joint), is challenging to treat. Work up often involves short-lived diagnostic and therapeutic anesthetic blocks to the medial branch of the dorsal ramus, which innervates the pain-generating Z-joint. Current procedure requires patients to have significant pain relief on 2 subsequent medial branch blocks (MBB) to confirm the diagnosis and nerve target in order to progress to a radiofrequency ablation (RFA), a procedure in which the medial branch is ablated for longstanding pain relief. Unlike RFA in the lumbar levels, the efficacy of RFA in the thoracic levels has not been well described. We believe that this may be due to the unique neuroanatomy in the thoracic spine and the overall paucity of data. We hypothesize that thoracic RFA is not effective, particularly in the mid-thoracic levels, when compared to lumbar RFA data. Modification of the thoracic RFA procedure may be necessary to accomodate the unique neuroanatomy of this region. | 1 | Chart review for data collection and analysis. Opportunities for article writing and presentation. | Prior experience with data collection/analysis and writing. | IRB approved | No | Yes | Yes | Not currently available to mentor other students | No | No | Michele Luu (mluu@uwhealth.org), Delilah Kowalke (kowalke@rehab.wisc.edu), Samuel Mosiman (mosiman@ortho.wisc.edu) | Nalini Sehgal, Sehgal@rehab.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufNyrqeKRpymktKyepcMxbevUllbbDP033B--WJ-xoXLO_KXw2upGwFUP14XrYxzbo | |||||||||||
| 01/02/2023 | jdkratz@medicine.wisc.edu | Jeremy | Kratz | MD | Assistant Professor | 608 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Predictive Modeling from the VA's National Precision Oncology Program: In concert with the President Biden’s Cancer Moonshot, significant resources have been invested in characterizing the molecular changes that make cancer unique to an individual. In response to these efforts, the Veteran’s Administration has launched the National Precision Oncology Program dedicated to characterize the breadth of molecular findings across the integrated VA network. No studies to date have characterized the unique molecular alterations in Veterans with Gastrointestinal oncology for which this data set serves integral to understanding unique targets and the role of environmental exposure in driving distinct pathologic alterations. This project includes understanding modern techniques in defining clinically actionable molecular targets across cancer types. We are looking for two students for dedicated projects to be considered including: 1) Characterizing the frequency of homologous recombination alterations in pancreatic cancer as a predictive biomarker in the durability of platinum chemotherapy 2) Characterizing the breadth of molecular alterations in cholangiocarcinoma differ as a function of military service and exposure histories 3) Characterize how molecular profiling in hepatocellular carcinoma differs as a function of viral hepatitis, alcoholic cirrhosis, versus NASH/NAFLD. ____________________________________________________________________________ Role - Research Assistant; IRB Status - Approved; Skills - Handling large scale datasets (preference with coding experience) | Hematology, Oncology and Palliative CAre | Oncology | N/A | Predictive Modeling from the VA's National Precision Oncology Program | In concert with the President Biden’s Cancer Moonshot, significant resources have been invested in characterizing the molecular changes that make cancer unique to an individual. In response to these efforts, the Veteran’s Administration has launched the National Precision Oncology Program dedicated to characterize the breadth of molecular findings across the integrated VA network. No studies to date have characterized the unique molecular alterations in Veterans with Gastrointestinal oncology for which this data set serves integral to understanding unique targets and the role of environmental exposure in driving distinct pathologic alterations. This project includes understanding modern techniques in defining clinically actionable molecular targets across cancer types. We are looking for two students for dedicated projects to be considered including: 1) Characterizing the frequency of homologous recombination alterations in pancreatic cancer as a predictive biomarker in the durability of platinum chemotherapy 2) Characterizing the breadth of molecular alterations in cholangiocarcinoma differ as a function of military service and exposure histories 3) Characterize how molecular profiling in hepatocellular carcinoma differs as a function of viral hepatitis, alcoholic cirrhosis, versus NASH/NAFLD. | 2 | Research Assistant | None | Handling large scale datasets (preference with coding experience) | Approved | No | Yes | Yes | Genetic Counseling students, MPH students, PhD students, UW undergraduates interested in research | No | Yes | Austin Stram astram@wisc.edu | Jeremy Kratz, jdkratz@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueqQTWKJtP6OI842zbcS22oRkziQZIgOu-z3uQLfjpL9adT0opSwvTaEwy1qhZTyIk | |||||
| 01/03/2023 | cosper@wisc.edu | Pippa | Cosper | MD, PhD | Assistant Professor | 3.038.878.110 | Human Oncology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Effect of chromosomal instability on radiation sensitivity in HPV-associated cancers: Human papilloma virus (HPV) causes 5% of cancers worldwide, including cervical and head and neck cancers. All advanced cervical cancers are treated similarly with definitive chemoradiation but about 30% of patients don’t respond and have a poor prognosis. Thus despite a common etiology and similar tumor biology, the treatment response is quite different, for reasons we don’t understand. Chromosomal instability (CIN), or an ongoing rate of chromosome missegregation events over the course of multiple cell divisions, is very common in cancer cells and is induced by HPV. My lab studies how HPV induces CIN and how different mechanisms of CIN affect sensitivity to radiation treatment. The ultimate goal is to create a more personalized approach to chemoradiation therapy based upon each patient’s tumor characteristics. This project will involve staining patient cervical tumor samples, quantifying CIN, and correlating with patient outcome. It will also involve simple basic science experiments that validate certain findings. https://www.humonc.wisc.edu/team_member/pippa-cosper-md-phd/ ____________________________________________________________________________ Role - Chart review to determine patient tissues eligible for study as well as noting their treatment outcome. Student will also perform staining of tissue samples, quantification of certain biological characteristics as well as simple basic science experiments such as cell culture.; IRB Status - Approved; Skills - ideally basic laboratory skills, but these are teachable. | Effect of chromosomal instability on radiation sensitivity in HPV-associated cancers | Human papilloma virus (HPV) causes 5% of cancers worldwide, including cervical and head and neck cancers. All advanced cervical cancers are treated similarly with definitive chemoradiation but about 30% of patients don’t respond and have a poor prognosis. Thus despite a common etiology and similar tumor biology, the treatment response is quite different, for reasons we don’t understand. Chromosomal instability (CIN), or an ongoing rate of chromosome missegregation events over the course of multiple cell divisions, is very common in cancer cells and is induced by HPV. My lab studies how HPV induces CIN and how different mechanisms of CIN affect sensitivity to radiation treatment. The ultimate goal is to create a more personalized approach to chemoradiation therapy based upon each patient’s tumor characteristics. This project will involve staining patient cervical tumor samples, quantifying CIN, and correlating with patient outcome. It will also involve simple basic science experiments that validate certain findings. https://www.humonc.wisc.edu/team_member/pippa-cosper-md-phd/ | 1 | Chart review to determine patient tissues eligible for study as well as noting their treatment outcome. Student will also perform staining of tissue samples, quantification of certain biological characteristics as well as simple basic science experiments such as cell culture. | Moderate. I will train the student and then they will likely be able to continue on their own with my guidance. | ideally basic laboratory skills, but these are teachable. | Approved | Yes | Yes | Yes | PhD students | No | No | N/A | Pippa Cosper, cosper@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudrzqe9qbu6YF8GaNlIjgNp7cdbPCjBDxorHARuiwDVsnIndotu3j3PazYKDzjgovo | ||||||||
| 01/03/2023 | jmkessel@wisc.edu | Julie | Kessel | MD | Associate Professor of Neonatology | 0 | Pediatrics | Research Electives for credit | On Wisconsin Center for Learning and Patient Safety (OWLS) Procedural Simulation Project: Newborn critical care medicine is one of the fastest evolving pediatric subspecialties. In the past three decades, there have been significant advances in neonatology that have contributed to improved survival rates for premature and critically ill newborns. These include the use of antenatal steroid treatment to improve lung development and reduce respiratory problems in premature infants, surfactant therapy to help newborns with respiratory distress syndrome breathe more easily, improved nutrition for better growth and development, and advances in technology such as mechanical ventilation and enhanced monitoring systems. Despite medical advances, neonatal providers have fewer opportunities during training to learn and perform life-saving procedures for airway stabilization, such as endotracheal tube intubation and chest tube placement. Consequently, both residents and fellows can finish training with limited procedural experience. The neonatology workforce, which includes trainees, neonatologists, neonatal advanced practitioners and medical transport staff, all need to practice intubation and chest tube placement skills to maintain competency. Realistic medical simulations and skills labs are important educational tools that can increase confidence, decrease errors, and improve patient safety. The Division of Neonatology at the UWSMPH is building a state-of-the-art simulation center known as the On Wisconsin Center for Learning and Patient Safety (OWLS). OWLS is committed to improving neonatal clinical care with novel research in simulation related fields. During the past several years, basic simulation models and competencies for neonatal procedures have been developed and used during simulation skills labs. This project will address a need to find innovative ways to improve these models and develop tools to evaluate the impact of procedural simulations. The project will focus on two procedures: chest tube placement (placement of a chest tube into the thoracic cavity to provide a way to remove air and fluid surrounding the lung) and intubation (placement of an endotracheal tube into a neonatal airway to provide respiratory support). Division members and pediatric trainees with varying experience levels will simulate chest tube placement under the observation of the Shapiro student and a member of the OWLS leadership team. Assessment tools will include a pre- and post-test survey on basic procedural knowledge completed by the participants and a competency checklist completed by the student observer. The conditions for the simulation will be varied and include quiet conditions and a simulated complex resuscitation mimicking a real-life scenario. Goals for the chest tube procedural simulation are to determine the procedural milestones to be obtained by the level of learner. These milestones will help to guide future simulations tailored to level of clinical experience. A second goal is to evaluate the impact on stress on performance including competencies most affected during stressful situations. This data may help prevent medical errors and patient safely issues. For the intubation simulation, the focus will be on visible hand and body position during the procedure. During a simulated intubation, individuals will be asked to verbalize the moment at which the endotracheal tube passes through the vocal cords and photographs or video will be taken and later analyzed for hand and body position. Goals for the intubation simulation are to analyze body mechanics during intubation and to determine which positions are associated with intubation success or failure. ____________________________________________________________________________ Role - The student will work closely with the OWLS multidisciplinary leadership team. For the chest tube simulation, the student will be involved in creating assessments to evaluate competencies/milestones in 3 areas including the ability of the learner to: 1) assess the risk and benefits of the procedure, 2) complete essential elements of a procedural checklist including appropriate consent and equipment choice, and 3) document and communicate procedures. The student will help recruit participants, organize the simulations, observe and complete a competency checklist, and analyze and present the data. For intubation, the student will photograph or capture video of providers with a range of experience levels performing simulated intubations and then analyze the images for patterns of arm, head, and body position during successful attempts, and help interpret this data. We envision presentations and publications that will come from these projects that will include the Shapiro student as an author. ; IRB Status - N/A; Skills - none | Neonatology | Ryan McAdams, MD, Adam Bauer, MD, Tim Elgin, MD and Kate Hirsch, NNP | Pediatrics | Neonatology | On Wisconsin Center for Learning and Patient Safety (OWLS) Procedural Simulation Project | Newborn critical care medicine is one of the fastest evolving pediatric subspecialties. In the past three decades, there have been significant advances in neonatology that have contributed to improved survival rates for premature and critically ill newborns. These include the use of antenatal steroid treatment to improve lung development and reduce respiratory problems in premature infants, surfactant therapy to help newborns with respiratory distress syndrome breathe more easily, improved nutrition for better growth and development, and advances in technology such as mechanical ventilation and enhanced monitoring systems. Despite medical advances, neonatal providers have fewer opportunities during training to learn and perform life-saving procedures for airway stabilization, such as endotracheal tube intubation and chest tube placement. Consequently, both residents and fellows can finish training with limited procedural experience. The neonatology workforce, which includes trainees, neonatologists, neonatal advanced practitioners and medical transport staff, all need to practice intubation and chest tube placement skills to maintain competency. Realistic medical simulations and skills labs are important educational tools that can increase confidence, decrease errors, and improve patient safety. The Division of Neonatology at the UWSMPH is building a state-of-the-art simulation center known as the On Wisconsin Center for Learning and Patient Safety (OWLS). OWLS is committed to improving neonatal clinical care with novel research in simulation related fields. During the past several years, basic simulation models and competencies for neonatal procedures have been developed and used during simulation skills labs. This project will address a need to find innovative ways to improve these models and develop tools to evaluate the impact of procedural simulations. The project will focus on two procedures: chest tube placement (placement of a chest tube into the thoracic cavity to provide a way to remove air and fluid surrounding the lung) and intubation (placement of an endotracheal tube into a neonatal airway to provide respiratory support). Division members and pediatric trainees with varying experience levels will simulate chest tube placement under the observation of the Shapiro student and a member of the OWLS leadership team. Assessment tools will include a pre- and post-test survey on basic procedural knowledge completed by the participants and a competency checklist completed by the student observer. The conditions for the simulation will be varied and include quiet conditions and a simulated complex resuscitation mimicking a real-life scenario. Goals for the chest tube procedural simulation are to determine the procedural milestones to be obtained by the level of learner. These milestones will help to guide future simulations tailored to level of clinical experience. A second goal is to evaluate the impact on stress on performance including competencies most affected during stressful situations. This data may help prevent medical errors and patient safely issues. For the intubation simulation, the focus will be on visible hand and body position during the procedure. During a simulated intubation, individuals will be asked to verbalize the moment at which the endotracheal tube passes through the vocal cords and photographs or video will be taken and later analyzed for hand and body position. Goals for the intubation simulation are to analyze body mechanics during intubation and to determine which positions are associated with intubation success or failure. | 1 | The student will work closely with the OWLS multidisciplinary leadership team. For the chest tube simulation, the student will be involved in creating assessments to evaluate competencies/milestones in 3 areas including the ability of the learner to: 1) assess the risk and benefits of the procedure, 2) complete essential elements of a procedural checklist including appropriate consent and equipment choice, and 3) document and communicate procedures. The student will help recruit participants, organize the simulations, observe and complete a competency checklist, and analyze and present the data. For intubation, the student will photograph or capture video of providers with a range of experience levels performing simulated intubations and then analyze the images for patterns of arm, head, and body position during successful attempts, and help interpret this data. We envision presentations and publications that will come from these projects that will include the Shapiro student as an author. | Independence with support and oversight of leadership team | none | N/A | No | No (plan to use Dean's Office Funds) | Yes | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Yes | No | Dr Ryan McAdams (mcadams@pediatrics.wisc.edu) | Julie Kessel, jmkessel@wisc.edu -- Co-Mentor: Ryan McAdams, MD, Adam Bauer, MD, Tim Elgin, MD and Kate Hirsch, NNP | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudNmL7EGr19-lI15GlhSZeHzmbHMox7mv_54EZMej9J3zO7eQI-L7TzBowSMTwKES8 | ||||
| 01/04/2023 | afowler@wisc.edu | Amy | Fowler | MD, PhD | Associate Professor | 608 | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Role of Imaging in Evaluation of Breast Pain: The project consists of a literature review culminating in an imaging-rich manuscript of the spectrum of causes of breast pain, clinical presentation, radiological imaging features, and management. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ ____________________________________________________________________________ Role - Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of breast pain. Images from case examples have been collected and will need to be organized as figures in the manuscript.; IRB Status - N/A; Skills - Strong work ethic, reliability, and enthusiasm for the project | Breast Imaging and Intervention | Role of Imaging in Evaluation of Breast Pain | The project consists of a literature review culminating in an imaging-rich manuscript of the spectrum of causes of breast pain, clinical presentation, radiological imaging features, and management. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ | 1 | Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of breast pain. Images from case examples have been collected and will need to be organized as figures in the manuscript. | A moderate degree of independence is required for completion of this project. | Strong work ethic, reliability, and enthusiasm for the project | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | Yes | No | Lorene Seman: LSeman@uwhealth.org | Amy Fowler, afowler@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudsaPOCxjgGmnRk8OJZLAAxeELiJxHiQf_lkF49iIJNEwqf-3pAlkQtdcDqCG6_o7k | |||||||
| 01/09/2023 | afowler@wisc.edu | Amy | Fowler | MD, PhD | Associate Professor | Radiology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Diagnostic Performance of Breast Imaging during Pregnancy and Lactation: A Systematic Review and Meta-Analysis: The project consists of a literature review of the diagnostic performance (sensitivity, specificity, positive predictive value, negative predictive value) of breast imaging (mammography, ultrasound, MRI) performed for breast cancer screening and diagnosis during pregnancy and lactation. The project will culminate in a systematic review and meta-analysis that will be submitted as a publication in a peer-reviewed journal. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ ____________________________________________________________________________ Role - Under the supervision of the project mentor, the student will design and perform a literature review on the diagnostic performance of breast imaging during pregnancy and lactation. Images from case examples have been collected and will need to be organized as figures in the manuscript.; IRB Status - N/A; Skills - Strong work ethic, reliability, and enthusiasm for the project | Breast Imaging and Intervention | Medical Physics | Laura Bozzuto, MD, MS | bozzuto@wisc.edu | Obstetrics & Gynecology | Diagnostic Performance of Breast Imaging during Pregnancy and Lactation: A Systematic Review and Meta-Analysis | The project consists of a literature review of the diagnostic performance (sensitivity, specificity, positive predictive value, negative predictive value) of breast imaging (mammography, ultrasound, MRI) performed for breast cancer screening and diagnosis during pregnancy and lactation. The project will culminate in a systematic review and meta-analysis that will be submitted as a publication in a peer-reviewed journal. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ | 1 | Under the supervision of the project mentor, the student will design and perform a literature review on the diagnostic performance of breast imaging during pregnancy and lactation. Images from case examples have been collected and will need to be organized as figures in the manuscript. | A moderate degree of independence is required for completion of this project. | Strong work ethic, reliability, and enthusiasm for the project | N/A | No | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | Yes | No | Lorene Seman: LSeman@uwhealth.org | Amy Fowler, afowler@wisc.edu -- Co-Mentor: Laura Bozzuto, MD, MS bozzuto@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudkK4TZqjoQjAExuWYdP3eDp_43_YwZo2BcHKpbsYT2qYxlyHwqThIZ2zUTp0BUlzo | ||||
| nosanov@surgery.wisc.edu | Lauren | Nosanov | MD | Assistant Professor of Surgery | 516 | Surgery | Shorter term projects | Retrospective Multi-Center Study Examining Surgical Treatment of Older Adult Burn Patients: This is a multi-institutional review of elderly burn patients being performed at Burn Centers across the country. The primary focus is to evaluate the role of frailty in clinical outcomes. ____________________________________________________________________________ Role - Data collection via chart review and entry into REDCap; IRB Status - Pending; Skills - Ability to read operative reports | Retrospective Multi-Center Study Examining Surgical Treatment of Older Adult Burn Patients | This is a multi-institutional review of elderly burn patients being performed at Burn Centers across the country. The primary focus is to evaluate the role of frailty in clinical outcomes. | 0 | Data collection via chart review and entry into REDCap | moderate | Ability to read operative reports | Pending | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | N/A | Lauren Nosanov, nosanov@surgery.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudA6-tsbEqGFLAeHR0zkZ-VCL1FMWMvY7-Hy_IluqogBVAXk2pdBMgvF9js0zBKssE | |||||||||
| 01/06/2023 | rmrichards3@wisc.edu | Rebecca | Richards | MD/PhD | Assistant Professor | 6.082.659.645 | Pediatrics | Opportunity to extend a project from the summer into the school year if there is interest and time | Defining antigen density requirements for AML CAR-T cell success: Chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment of relapsed and refractory B cell malignancies. Progress has been slower in solid tumors and myeloid malignancies. My lab is interested in improving CAR-T cell therapy for acute myeloid leukemia (AML) so more patients are eligible for this type of immunotherapy when standard chemotherapy does not work. Antigen density on the tumor cells has been recognized as an important determinant of CAR-T cell efficacy in other tumors, but data are lacking for AML. Because AML is a heterogeneous tumor and may require targeting of multiple antigens simultaneously or in sequence, this is a critical question. This project would involve assessing target antigen density on the surface of tumor cells and testing CAR-T cells against tumors with low, medium, or high antigen density. The student would work with a senior scientist in the lab and would learn and employ basic science laboratory techniques such as cell culture, flow cytometry, ELISA, and in vitro cytotoxicity assays. ____________________________________________________________________________ Role - Depending on experience, primary researcher with support from a senior scientist; IRB Status - N/A; Skills - The student needs to be motivated, eager to learn, and a good communicator. Prior lab experience, particularly with cell culture and sterile technique, will definitely help the student to get the most out of their time in the lab. | Pediatric Hematology, Oncology & Bone Marrow Transplant | Defining antigen density requirements for AML CAR-T cell success | Chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment of relapsed and refractory B cell malignancies. Progress has been slower in solid tumors and myeloid malignancies. My lab is interested in improving CAR-T cell therapy for acute myeloid leukemia (AML) so more patients are eligible for this type of immunotherapy when standard chemotherapy does not work. Antigen density on the tumor cells has been recognized as an important determinant of CAR-T cell efficacy in other tumors, but data are lacking for AML. Because AML is a heterogeneous tumor and may require targeting of multiple antigens simultaneously or in sequence, this is a critical question. This project would involve assessing target antigen density on the surface of tumor cells and testing CAR-T cells against tumors with low, medium, or high antigen density. The student would work with a senior scientist in the lab and would learn and employ basic science laboratory techniques such as cell culture, flow cytometry, ELISA, and in vitro cytotoxicity assays. | 1 | Depending on experience, primary researcher with support from a senior scientist | Prior lab experience preferred | The student needs to be motivated, eager to learn, and a good communicator. Prior lab experience, particularly with cell culture and sterile technique, will definitely help the student to get the most out of their time in the lab. | N/A | Yes | Unsure - would need to understand what this requires | Yes | PhD students, UW undergraduates interested in research | No | No | N/A | Rebecca Richards, rmrichards3@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuchnkKyegvoyT7sTZ6uedSUVe8L4EA-jNR9qNZfS0aj4uWnZtzAXXri1GaOFjzXyc4 | |||||||
| 01/06/2023 | ltaylor@medicine.wisc.edu | Lindsay | Taylor | MD, MS | Assistant Professor | 414 | Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Analysis of nursing home provider antibiotic prescribing: With the goal of promoting and supporting antibiotic stewardship in nursing homes, we have completed a nationwide survey of nursing home providers to better understand how they make empiric antibiotic decision for urinary tract infections. We will examine variables associated with active and optimal empiric antibiotic choice using regression models. The student will work with the study team to complete the analysis of this existing dataset and prepare it for abstract/publication. ____________________________________________________________________________ Role - Use existing dataset for analysis, prepare, and submit results for abstract/manuscript.; IRB Status - N/A; Skills - writing, data analysis (can be taught) | Infectious Disease | Chris Crnich | cjc@medicine.wisc.edu | Medicine | Infectious Disease | Analysis of nursing home provider antibiotic prescribing | With the goal of promoting and supporting antibiotic stewardship in nursing homes, we have completed a nationwide survey of nursing home providers to better understand how they make empiric antibiotic decision for urinary tract infections. We will examine variables associated with active and optimal empiric antibiotic choice using regression models. The student will work with the study team to complete the analysis of this existing dataset and prepare it for abstract/publication. | 1 | Use existing dataset for analysis, prepare, and submit results for abstract/manuscript. | moderate | writing, data analysis (can be taught) | N/A | AHRQ | Yes | Yes | Not currently available to mentor other students | No | Yes | sajolles@medicine.wisc.edu | Lindsay Taylor, ltaylor@medicine.wisc.edu -- Co-Mentor: Chris Crnich cjc@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufaioX_gvTUlVpUH4uSRkuM_pzmAaGnG8qkvzo8aUy2uk6oMqz_U8EFxpZGaZcwObo | |||
| 01/09/2023 | bozzuto@wisc.edu | Laura | Bozzuto | MD | Assistant Professor | 6.035.545.597 | Obstetrics & Gynecology | Shorter term projects | Improving care for granulomatous mastitis : Granulomatous mastitis is an uncommon benign breast disorder that can affect women of reproductive age causing significant pain, scarring, and distress. Care for GM can take months and involve multiple different specialties to manage. As part of quality improvement efforts in the breast center at the UW Carbone Cancer Center, the care administered to patients with GM is looking to be optimized. This project entails performing a baseline assessment of care utilization as part of a quality improvement process. Ongoing engagement may be an option. ____________________________________________________________________________ Role - Data collection, chart review, literature review; IRB Status - n/a - quality improvement; Skills - none | Academic Specialists in Obstetrics and Gynecology | Surgery | Surgical Oncology | Improving care for granulomatous mastitis | Granulomatous mastitis is an uncommon benign breast disorder that can affect women of reproductive age causing significant pain, scarring, and distress. Care for GM can take months and involve multiple different specialties to manage. As part of quality improvement efforts in the breast center at the UW Carbone Cancer Center, the care administered to patients with GM is looking to be optimized. This project entails performing a baseline assessment of care utilization as part of a quality improvement process. Ongoing engagement may be an option. | 1 | Data collection, chart review, literature review | comfort with data collection and chart review | none | n/a - quality improvement | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Yes | Tanya Kroll (TKroll@uwhealth.org), Meeghan Lautner (lautner@surger.wisc.edu) | Laura Bozzuto, bozzuto@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuc4oueJJGQpTECxrak_WJ3YIz5IXT6fkLb6CstMhlwlLN9IvUmbyfzTbn2fR2RMR60 | |||||
| 01/10/2023 | krisjon.olson@gmail.com | Krisjon | Olson | Ph.D. | Assistant Professor | 5.102.297.337 | Pediatrics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Accessible Transition Readiness Assessment (aTRA): Adapting an Intervention for Congenital Heart Disease Survivors with Disabilities: Adults with CHD now outnumber children, and an underestimation of their disability-related needs in the health care transition (HCT) from pediatric to adult care is both deadly and expensive with an annual cost of 5.6 billion. Evidence for the importance of HCT in adolescents with chronic conditions is extensive. However, few studies compare results for patients with and without disabilities. Disabilities associated with CHD may change slowly with poor-to-moderate differentiation or remain minimal through effective corrective surgery. As with the general population, incidence of disability increases with age. How CHD survivors experience aging-related disabilities is largely unknown. Therefore, screening all survivors is an essential first step. But the efficacy of current tools, including the Transition Readiness Assessment (TRA) tool and its educational components, has not been demonstrated. Central to the controversy within CHD transitional care is the lack of randomized, controlled clinical trial data proving which forms of intervention reduce associated morbidity and mortality. We do know that less than 15% of outcome differences are attributed to biology, and scientists have called for further study of the environmental and social factors that may impact survivors over their life course. The benefits of early disability identification, targeted education, or monitoring who is most at risk for missed follow-up has not been fully examined. Risks of unsuccessful or delayed transition to adult care include progression of preventable illness, anxiety from chronic health uncertainty, and unnecessary or iatrogenic treatments related to absent specialized care. Rates of treatment-related disability for CHD, especially problems of neurocognition, are reported to vary widely by treatment modality. This is in part due to a lack of standard follow-up care, reliance on retrospective rather than prospective patient or parent reporting, and failure to account for pre-treatment function. Problems with neurocognition (greater than 50%) and mobility (5-20%) are thought to be more common in patients who undergo bypass at young ages. All types of disability are most common in critical CHD patients (90%) who have surgery in the first year of life, though this is also associated with underlying genetic diagnoses (20%-45%) and multiple heart defects (20%-80%). Despite these differences, our research has shown that CHD survivors with and without disabilities lack knowledge of supported decision making and have misconceptions about HCT. Our observations and the TRA has shown us that some survivors and their support person have difficulty identifying their heart condition, struggle with health care insurance or medications, and lack coordinated education support and employment services. By further differentiating the TRA tool with survivors to address disability related needs, we will design an effective intervention and measure outcomes meaningful to participants and their communities The American Heart Association, American Academy of Pediatrics and the Centers for Disease Control and Prevention all recommend CHD survivors seek specialized lifelong care so they can avoid harmful treatments and make informed decisions. However, there has only been one small trial on the reduction of CHD mortality and transition intervention. A demographic shift in mortality from childhood to adulthood, especially at time of care transition between 17-26 years, indicates that some – probably most – survivors are not getting the information and support they need. Until now, disability has largely been unrecognized as a related CHD health problem. CHD survivors with disabilities are four times more likely to report their health to be fair or poor than people without disabilities (40% vs 9%), mirroring the experience of disabled Americans. Social, economic, and vocational disadvantages might be avoided if survivors are identified early, tracked, and linked to robust wraparound supports and services. Studies of transition programs for medically complex children suggest that patients can improve knowledge, and increase interest and participation in follow up. None have examined how disability impacts the HCT for CHD; our preliminary data indicates long-term support networks, not just differences in patient knowledge, are relevant. ____________________________________________________________________________ Role - Review and contribution to clinical database, other sub-projects based on skills/interest; IRB Status - Approved; Skills - Subject matter familiarity with health care in childhood, clinical trials, public health, epidemiology or integrative biology, and an interest in science and technology studies or disability studies is strongly preferred. The candidate must have the requisite skills to ensure comprehensive data collection of biological measures, timely completion of Interest in learning about qualitative interviews, coding, data management, and inclusion of populations historically marginalized in medical research preferred. Previous experience working in collaboration with community-based organizations or with people with disabilities would be highly valued, but is not required. | Cardiology | Xiao Zhang, Associate Scientist | xiao.zhang@wisc.edu | Pediatrics | Cardiology | Accessible Transition Readiness Assessment (aTRA): Adapting an Intervention for Congenital Heart Disease Survivors with Disabilities | Adults with CHD now outnumber children, and an underestimation of their disability-related needs in the health care transition (HCT) from pediatric to adult care is both deadly and expensive with an annual cost of 5.6 billion. Evidence for the importance of HCT in adolescents with chronic conditions is extensive. However, few studies compare results for patients with and without disabilities. Disabilities associated with CHD may change slowly with poor-to-moderate differentiation or remain minimal through effective corrective surgery. As with the general population, incidence of disability increases with age. How CHD survivors experience aging-related disabilities is largely unknown. Therefore, screening all survivors is an essential first step. But the efficacy of current tools, including the Transition Readiness Assessment (TRA) tool and its educational components, has not been demonstrated. Central to the controversy within CHD transitional care is the lack of randomized, controlled clinical trial data proving which forms of intervention reduce associated morbidity and mortality. We do know that less than 15% of outcome differences are attributed to biology, and scientists have called for further study of the environmental and social factors that may impact survivors over their life course. The benefits of early disability identification, targeted education, or monitoring who is most at risk for missed follow-up has not been fully examined. Risks of unsuccessful or delayed transition to adult care include progression of preventable illness, anxiety from chronic health uncertainty, and unnecessary or iatrogenic treatments related to absent specialized care. Rates of treatment-related disability for CHD, especially problems of neurocognition, are reported to vary widely by treatment modality. This is in part due to a lack of standard follow-up care, reliance on retrospective rather than prospective patient or parent reporting, and failure to account for pre-treatment function. Problems with neurocognition (greater than 50%) and mobility (5-20%) are thought to be more common in patients who undergo bypass at young ages. All types of disability are most common in critical CHD patients (90%) who have surgery in the first year of life, though this is also associated with underlying genetic diagnoses (20%-45%) and multiple heart defects (20%-80%). Despite these differences, our research has shown that CHD survivors with and without disabilities lack knowledge of supported decision making and have misconceptions about HCT. Our observations and the TRA has shown us that some survivors and their support person have difficulty identifying their heart condition, struggle with health care insurance or medications, and lack coordinated education support and employment services. By further differentiating the TRA tool with survivors to address disability related needs, we will design an effective intervention and measure outcomes meaningful to participants and their communities The American Heart Association, American Academy of Pediatrics and the Centers for Disease Control and Prevention all recommend CHD survivors seek specialized lifelong care so they can avoid harmful treatments and make informed decisions. However, there has only been one small trial on the reduction of CHD mortality and transition intervention. A demographic shift in mortality from childhood to adulthood, especially at time of care transition between 17-26 years, indicates that some – probably most – survivors are not getting the information and support they need. Until now, disability has largely been unrecognized as a related CHD health problem. CHD survivors with disabilities are four times more likely to report their health to be fair or poor than people without disabilities (40% vs 9%), mirroring the experience of disabled Americans. Social, economic, and vocational disadvantages might be avoided if survivors are identified early, tracked, and linked to robust wraparound supports and services. Studies of transition programs for medically complex children suggest that patients can improve knowledge, and increase interest and participation in follow up. None have examined how disability impacts the HCT for CHD; our preliminary data indicates long-term support networks, not just differences in patient knowledge, are relevant. | 1 | Review and contribution to clinical database, other sub-projects based on skills/interest | Motivated and willing to work on a team | Subject matter familiarity with health care in childhood, clinical trials, public health, epidemiology or integrative biology, and an interest in science and technology studies or disability studies is strongly preferred. The candidate must have the requisite skills to ensure comprehensive data collection of biological measures, timely completion of Interest in learning about qualitative interviews, coding, data management, and inclusion of populations historically marginalized in medical research preferred. Previous experience working in collaboration with community-based organizations or with people with disabilities would be highly valued, but is not required. | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | Krisjon Olson, Kelly Kalasheur, Xiao Zhang | Krisjon Olson, krisjon.olson@gmail.com -- Co-Mentor: Xiao Zhang, Associate Scientist xiao.zhang@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueYM8thzCN3hQ7_t4B_6nGRdL2wMQ9E5_yxnXiblLeDbjSM-8ZF3yqw2WFqcsZrsYQ | |||
| 01/10/2023 | krisjon.olson@wisc.edu | Krisjon | Olson | Ph.D. | Assistant Professor | 5.102.297.337 | Pediatrics | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | CCHD GAP: Creating Long-Term Health Parity by Closing the Gender Gap in Critical Congenital Heart Disease: Social scientists have made remarkable progress understanding family variation (single parenting, delayed parenthood, formal and informal adoption, assisted reproduction, and other kinship) prevalent in the United States today. But theoretical models have lagged in their explanation of how changes in family structure impact medical care, decision-making, and outcomes in pediatrics. Parents of children with CCHD must decide whether to pursue (1) corrective surgery or (2) palliative interventions (which do not correct, but ideally improve, cardiovascular function). All treatment includes multiple invasive surgeries and admissions to the pediatric intensive care unit (PICU). Existing guidance presumes participation of a mother and father without accounting for additional kin or family. Our research shows that this type of traditional parental decision-making occurs in only 14% of cases. Additionally, prognostic information for CCHD is largely limited to the mortality risks of complications or relative advantage of isolated procedures. Retrospective reports of girls who survive point to a gender-health paradox: women with CCHD experience more sickness over their lifetime. They may also be less likely to receive the advanced surgical and medical therapies in childhood (heart transplant, extracorporeal life support, ventricular assist devices) that have dramatically extended life expectancy for survivors. When they do, initial outcomes are similar: a marked departure from other pediatric diseases where girls have a survival advantage. This is often attributed to biological differences between the sexes, without examination of associated gender norms that may adversely affect outcomes. An estimated 83% of those that do receive advanced therapies suffer severe complications over their lifetime accounting for 10% of total spending in healthcare. Currently, we do not have a framework for understanding the lifelong consequences of the treatment decisions that caregivers must make while a child is hospitalized with CCHD. Families might make different choices if we better understood their composition, preferences, and goals of care. We have used an established tool to study health-related quality of life in the PICU called the Functional Status Scale, an outcome measure developed by the Collaborative Pediatric Critical Care Research Network for longitudinal investigation at the onset of critical illness. In preliminary feasibility testing we demonstrated that in 400 CCHD patients: 1) survivors of palliative interventions experience significant worsening of their functional status (>3) when they are discharged from the hospital and 2) the measure is feasible to use after pediatric cardiac surgery. Importantly, the tool allowed us to identify a higher risk group (i.e., CCHD survivors with disabilities) who have a higher incidence of complications and mortality rates over their lifetime, and a lower risk group (i.e., CCHD survivors without disabilities) who have a lower incidence of complications and mortality rates over their lifetime. Testing this tool as a measure of longer-term outcomes to correlate with hospital discharge morbidity is significant because it would help teams identify patients who would benefit most from crucial rehabilitation medicine to improve recovery. We must also assess family experience during a difficult time when caregivers are trying to decide what to do next. ____________________________________________________________________________ Role - Depends on interests/skills. Could include review of medical records, clinical database, approaching families etc.; IRB Status - Approved; Skills - Interest in qualitative methods. Willingness to include those historically excluded or underrepresented in clinical research, experience with community organizations a plus | Cardiology | Xiao Zhange | xiao.zhang@wisc.edu | Pediatrics | Cardiology | CCHD GAP: Creating Long-Term Health Parity by Closing the Gender Gap in Critical Congenital Heart Disease | Social scientists have made remarkable progress understanding family variation (single parenting, delayed parenthood, formal and informal adoption, assisted reproduction, and other kinship) prevalent in the United States today. But theoretical models have lagged in their explanation of how changes in family structure impact medical care, decision-making, and outcomes in pediatrics. Parents of children with CCHD must decide whether to pursue (1) corrective surgery or (2) palliative interventions (which do not correct, but ideally improve, cardiovascular function). All treatment includes multiple invasive surgeries and admissions to the pediatric intensive care unit (PICU). Existing guidance presumes participation of a mother and father without accounting for additional kin or family. Our research shows that this type of traditional parental decision-making occurs in only 14% of cases. Additionally, prognostic information for CCHD is largely limited to the mortality risks of complications or relative advantage of isolated procedures. Retrospective reports of girls who survive point to a gender-health paradox: women with CCHD experience more sickness over their lifetime. They may also be less likely to receive the advanced surgical and medical therapies in childhood (heart transplant, extracorporeal life support, ventricular assist devices) that have dramatically extended life expectancy for survivors. When they do, initial outcomes are similar: a marked departure from other pediatric diseases where girls have a survival advantage. This is often attributed to biological differences between the sexes, without examination of associated gender norms that may adversely affect outcomes. An estimated 83% of those that do receive advanced therapies suffer severe complications over their lifetime accounting for 10% of total spending in healthcare. Currently, we do not have a framework for understanding the lifelong consequences of the treatment decisions that caregivers must make while a child is hospitalized with CCHD. Families might make different choices if we better understood their composition, preferences, and goals of care. We have used an established tool to study health-related quality of life in the PICU called the Functional Status Scale, an outcome measure developed by the Collaborative Pediatric Critical Care Research Network for longitudinal investigation at the onset of critical illness. In preliminary feasibility testing we demonstrated that in 400 CCHD patients: 1) survivors of palliative interventions experience significant worsening of their functional status (>3) when they are discharged from the hospital and 2) the measure is feasible to use after pediatric cardiac surgery. Importantly, the tool allowed us to identify a higher risk group (i.e., CCHD survivors with disabilities) who have a higher incidence of complications and mortality rates over their lifetime, and a lower risk group (i.e., CCHD survivors without disabilities) who have a lower incidence of complications and mortality rates over their lifetime. Testing this tool as a measure of longer-term outcomes to correlate with hospital discharge morbidity is significant because it would help teams identify patients who would benefit most from crucial rehabilitation medicine to improve recovery. We must also assess family experience during a difficult time when caregivers are trying to decide what to do next. | 1 | Depends on interests/skills. Could include review of medical records, clinical database, approaching families etc. | Motivated and willing to work on a team | Interest in qualitative methods. Willingness to include those historically excluded or underrepresented in clinical research, experience with community organizations a plus | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | Krisjon Olson, Kelly Kalascheur, Xiao Zhang | Krisjon Olson, krisjon.olson@wisc.edu -- Co-Mentor: Xiao Zhange xiao.zhang@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuchx36c3zzoNCtfEW-PovOuEeWA9NQZalvHm4dsSzO0qnX12R8hayLwcxF0AFrdilU | |||
| 01/10/2023 | fkaiksow@wisc.edu | Farah | Kaiksow | MD, MPP | Assistant Professor (CHS) | 6.087.709.997 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | The impact of hospitalization on older incarcerated adults: As the incarcerated population ages rapidly, they will require more inpatient care. There is no data on whether these older adults receive age-friendly care as recommended by geriatric specialists. This project will investigate the incarceration-specific processes that impact older incarcerated patients and explore opportunities for clinical adjustments. ____________________________________________________________________________ Role - Collect and analyze quantitative and qualitative data.; IRB Status - Qualitative portion approved, Quantitative portion partially approved; Skills - None | Hospital Medicine | The impact of hospitalization on older incarcerated adults | As the incarcerated population ages rapidly, they will require more inpatient care. There is no data on whether these older adults receive age-friendly care as recommended by geriatric specialists. This project will investigate the incarceration-specific processes that impact older incarcerated patients and explore opportunities for clinical adjustments. | 1 | Collect and analyze quantitative and qualitative data. | None | Qualitative portion approved, Quantitative portion partially approved | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | None. | Farah Kaiksow, fkaiksow@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudCjPL1QAgWwHvKEtroGTL8W-huDY5YCmiNrKBWE_nbACr4fbbBfla4Ur04FXky3Z8 | ||||||||
| 01/10/2023 | awalaszek@wisc.edu | Art | Walaszek | MD | Professor | 608 | Psychiatry | Not currently interested or available for Non-Shapiro research mentoring of medical students | Improving dementia care in Wisconsin through education: Our team at the Wisconsin Alzheimer’s Institute works to improve the care of people with BPSD by teaching healthcare providers better assessment and management of BPSD and helping train the next generation of healthcare professionals to better detect and treat dementia. More info: https://wai.wisc.edu/improving-dementia-care-wi/ ____________________________________________________________________________ Role - The student could be involved in data acquisition, data analysis, presenting outcomes, and collaborating with our team.; IRB Status - We have IRB approval; Skills - An interest in improving the care of persons living with dementia | Medicine | Geriatric Medicine | Improving dementia care in Wisconsin through education | Our team at the Wisconsin Alzheimer’s Institute works to improve the care of people with BPSD by teaching healthcare providers better assessment and management of BPSD and helping train the next generation of healthcare professionals to better detect and treat dementia. More info: https://wai.wisc.edu/improving-dementia-care-wi/ | 0 | The student could be involved in data acquisition, data analysis, presenting outcomes, and collaborating with our team. | An interest in improving the care of persons living with dementia | We have IRB approval | No | Yes | Yes | Not currently available to mentor other students | Yes | Yes | Molly Schroeder, mjschroeder3@wisc.edu; Sarah Klein, sarah.klein@wisc.edu | Art Walaszek, awalaszek@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufwV5Hyw2wMjpkANTabH5rIXRMt6WVdgpnmhM9d_1YlMgx-2wPpmF9jYq7yKwSeJ1g | |||||||
| 01/11/2023 | amsingh@wisc.edu | Mary | Ehlenbach | MD | Associate Professor | 2.063.889.392 | Pediatrics | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Implementation and Impact of Health Equity Rounds in the Department of Pediatrics: Health Equity Rounds (HER) is a new case-based conference series in the Department of Pediatrics that seeks to address how social determinants impact the care we provide, including health equity. It is centered on the belief that medical education has the power to improve health equity. HER seeks to recognize and education on the role of implicit bias and structural racism in patient care. Nationally, HER is a new and innovative, and the University of Wisconsin School of Medicine and Public Health is leading center in implementing HER. This aim of this Shapiro project is to synthesize and disseminate the Health Equity Rounds idea, including our experience in the Department of Pediatrics implementing HER, as well as evaluate the impact of HER. Our goal is for the Shapiro student to have a submitted publication that describes HER, and details the stakeholders and steps from idea inception to implementation. Additionally, we expect to use qualitative research methods to understand who participates in HER and why, as well as how HER may impact clinical practice. The precise project will be tailored to the individual student’s strengths and interests, but may include literature review, surveys and/or focus groups. The student for this project should have an interest in literature review and qualitative methods, and a willingness to promote health equity in those patients that are suffer from health disparities or are historically excluded in medicine. ____________________________________________________________________________ Role - The precise project will be tailored to the individual student’s strengths and interests, but may include literature review, surveys and/or focus groups. The student for this project will review the literature related to health equity rounds, and employ qualitative methods (such as surveys, focus groups, etc) to evaluate and dissemination HER and its impact. ; IRB Status - Pending; Skills - Interest in qualitative methods | Allergy-Immunology | Mary L Ehlenbach | mehlenbach@pediatrics.wisc.edu | Pediatrics | Pediatric Complex Care | Implementation and Impact of Health Equity Rounds in the Department of Pediatrics | Health Equity Rounds (HER) is a new case-based conference series in the Department of Pediatrics that seeks to address how social determinants impact the care we provide, including health equity. It is centered on the belief that medical education has the power to improve health equity. HER seeks to recognize and education on the role of implicit bias and structural racism in patient care. Nationally, HER is a new and innovative, and the University of Wisconsin School of Medicine and Public Health is leading center in implementing HER. This aim of this Shapiro project is to synthesize and disseminate the Health Equity Rounds idea, including our experience in the Department of Pediatrics implementing HER, as well as evaluate the impact of HER. Our goal is for the Shapiro student to have a submitted publication that describes HER, and details the stakeholders and steps from idea inception to implementation. Additionally, we expect to use qualitative research methods to understand who participates in HER and why, as well as how HER may impact clinical practice. The precise project will be tailored to the individual student’s strengths and interests, but may include literature review, surveys and/or focus groups. The student for this project should have an interest in literature review and qualitative methods, and a willingness to promote health equity in those patients that are suffer from health disparities or are historically excluded in medicine. | 1 | The precise project will be tailored to the individual student’s strengths and interests, but may include literature review, surveys and/or focus groups. The student for this project will review the literature related to health equity rounds, and employ qualitative methods (such as surveys, focus groups, etc) to evaluate and dissemination HER and its impact. | No | Interest in qualitative methods | Pending | Yes | Will approach Department or Dean's office funds | Yes | MPH students, UW undergraduates interested in research | Yes | Yes | Jenna Contreras; jrcontreras@wisc.edu | Mary Ehlenbach, amsingh@wisc.edu -- Co-Mentor: Mary L Ehlenbach mehlenbach@pediatrics.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufiL0gQMcAbdfMnKvYyQ19JVQykIR6iHHS6spKTiUpg_f0m4d7bH9DbTzat-3zTXDw | |||
| 01/11/2023 | mspulia@medicine.wisc.edu | Michael | Pulia | MD PhD | Assistant Professor | Emergency Medicine | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Evaluation of the MeMed Host Response Assay in Older Adults with Suspected Pneumonia: There are opportunities for a student to join a variety of ongoing research projects aimed to improve diagnosis of infectious diseases and develop antibiotic stewardship innovations. This includes opportunities to participate in either qualitative and/or quantitative methods depending on the student's interests and prior experience. Please see my lab website for information on the various ongoing projects. https://emed.wisc.edu/research/emergency-care-infectious-diseases ____________________________________________________________________________ Role - Primarily data collection, analysis and writing. ; IRB Status - All projects are IRB approved; Skills - If the student would like to join a project involving quantitative methods, they must have some basic skills in statistics and utilization of a data analysis software (coding) | Evaluation of the MeMed Host Response Assay in Older Adults with Suspected Pneumonia | There are opportunities for a student to join a variety of ongoing research projects aimed to improve diagnosis of infectious diseases and develop antibiotic stewardship innovations. This includes opportunities to participate in either qualitative and/or quantitative methods depending on the student's interests and prior experience. Please see my lab website for information on the various ongoing projects. https://emed.wisc.edu/research/emergency-care-infectious-diseases | 1 | Primarily data collection, analysis and writing. | High | If the student would like to join a project involving quantitative methods, they must have some basic skills in statistics and utilization of a data analysis software (coding) | All projects are IRB approved | Yes | I believe DEM provides matching funds | Yes | MPH students, PhD students | No | Yes | N/A | Michael Pulia, mspulia@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufmqLly1eyJOOb-mwU8pi3I7ihxpG9uFCi3daK_PypEY8RUVY9_r1bjQBBpODxNVNU | |||||||||
| mramrat@medicine.wisc.edu | Mohun | Ramratnam | MD | Targeting mitochondrial potassium channels to treat heart disease | 443 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | The effect of cardiac ROMK inhibition on ROS production. : Mitochondrial potassium channel activity are intricately linked to cardio-protection. However, targeting the mitochondrial potassium cycle to treat human heart disease is challenging due to the lack of clarity that surrounds the specific physiologic roles that proteins play in K+ cycling. We study the recently discovered cardiac mitochondrial ROMK (renal outer medullary potassium channel) channel. We have found that inhibition of cardiac ROMK leads to improvements in a mouse model of myocardial ischemia reperfusion injury. In addition, ROMK inhibition leads to uncoupling of mitochondria – a process by which electron transport is not used to drive ATP synthesis. By uncoupling mitochondria, ROMK inhibition may lead to a reduction in reactive oxygen species production and preserve heart function in times of stress. This project aims is to measure ROS in hearts with loss of ROMK function. We use isolated mitochondria, Isolated cardiomyocytes and a whole mouse hearts for assessments. ____________________________________________________________________________ Role - The student will obtain guidance and supervision with the following tasks 1. Isolating mitochondria from mouse hearts 2. Running experiments with isolated mitochondria in a fluorometer to assess ROS production 3. Assist Dr. Ramratnam (work together) in a model of isolated mouse whole heart ischemia-reperfusion experiments 4. Assess protein quantification by western blotting of ROS production ; IRB Status - Biosafety protocol approved; Skills - Basic pippetting. Basic knowledge of laboratory work and good practise. OK with handling mice and OK with taking mouse training. Though not critical, knowledge of centrifugation, vortex, and protein assays would be beneficial. | Cardiovascular | The effect of cardiac ROMK inhibition on ROS production. | Mitochondrial potassium channel activity are intricately linked to cardio-protection. However, targeting the mitochondrial potassium cycle to treat human heart disease is challenging due to the lack of clarity that surrounds the specific physiologic roles that proteins play in K+ cycling. We study the recently discovered cardiac mitochondrial ROMK (renal outer medullary potassium channel) channel. We have found that inhibition of cardiac ROMK leads to improvements in a mouse model of myocardial ischemia reperfusion injury. In addition, ROMK inhibition leads to uncoupling of mitochondria – a process by which electron transport is not used to drive ATP synthesis. By uncoupling mitochondria, ROMK inhibition may lead to a reduction in reactive oxygen species production and preserve heart function in times of stress. This project aims is to measure ROS in hearts with loss of ROMK function. We use isolated mitochondria, Isolated cardiomyocytes and a whole mouse hearts for assessments. | 2 | The student will obtain guidance and supervision with the following tasks 1. Isolating mitochondria from mouse hearts 2. Running experiments with isolated mitochondria in a fluorometer to assess ROS production 3. Assist Dr. Ramratnam (work together) in a model of isolated mouse whole heart ischemia-reperfusion experiments 4. Assess protein quantification by western blotting of ROS production | Basic pippetting. Basic knowledge of laboratory work and good practise. OK with handling mice and OK with taking mouse training. Though not critical, knowledge of centrifugation, vortex, and protein assays would be beneficial. | Biosafety protocol approved | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | No | Diana Vertein, dvertein@medicine.wisc.edu | Mohun Ramratnam, mramrat@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuc90KIvw6JJiFt02f8nLr7PlrqpcdUBZl7Up8unAfpg2isVPexGv87d-DX2PexqbD4 | |||||||||
| jgrzybowski@wisc.edu | Jeff | Grzybowski | MD | Assistant Professor | 708 | Anesthesiology | Research Electives for credit | SimCheck: Use of a Checklist for Emergency Intubation: Airway checklists and bundles have existed for many years, with a landmark study showing the use of the Montpellier Airway Bundle in the ICU improved survival, but with recent work suggesting checklists are not helpful. Literature, however, groups experts and learners together. Learners may be prone to forget life-saving equipment or drugs when faced with the pressure of a patient emergency - for most trainees, cognitive aids are, in fact, lifesaving. We aim to prove that a simple airway checklist taught to learners will improve emergency intubation performance by using a simulation approach to a COVID intubation. ____________________________________________________________________________ Role - Schedule and run simulation sessions, collect data as they occur, interpret data, complete literature search of relevant literature, and write up a manuscript. ; IRB Status - Almost ready to submit; Skills - Enthusiasm to get things scheduled, confidence to run a simulation session (you don’t have to teach, but you do have to speak and tell people what to do), enthusiasm to make it happen, read/learn and write. | Regional Anesthesia | Micah Long- Assistant Professor | mtlong@wisc.edu | Anesthesiology | Critical Care | SimCheck: Use of a Checklist for Emergency Intubation | Airway checklists and bundles have existed for many years, with a landmark study showing the use of the Montpellier Airway Bundle in the ICU improved survival, but with recent work suggesting checklists are not helpful. Literature, however, groups experts and learners together. Learners may be prone to forget life-saving equipment or drugs when faced with the pressure of a patient emergency - for most trainees, cognitive aids are, in fact, lifesaving. We aim to prove that a simple airway checklist taught to learners will improve emergency intubation performance by using a simulation approach to a COVID intubation. | 1 | Schedule and run simulation sessions, collect data as they occur, interpret data, complete literature search of relevant literature, and write up a manuscript. | I offer daily check-ins, weekly half-day shadowing, and ongoing orientation. We will try to have a faculty at many of the sim sessions (and all the early ones). | Enthusiasm to get things scheduled, confidence to run a simulation session (you don’t have to teach, but you do have to speak and tell people what to do), enthusiasm to make it happen, read/learn and write. | Almost ready to submit | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | Yes | No | Jeremy Sullivan, PhD - jasullivan@wisc.edu | Jeff Grzybowski, jgrzybowski@wisc.edu -- Co-Mentor: Micah Long- Assistant Professor mtlong@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufyivaO_P9ZH_hsP50s_DpNfh92m-p51GMF5GNYNe9jeV0RfBdCUu9k1gHCmA16hPM | ||||
| abel@urology.wisc.edu | E Jason | Abel | MD | Professor | 6.086.928.256 | Urology | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Kidney cancer research projects: I focus on translational science and clinical research projects in kidney cancer. I have worked with approximately 20 summer students over the last 12 years in the Shapiro program and all students have been able to be co-authors on publications from these projects. If you are interested, email me and we can discuss projects based on your interests and experience. ____________________________________________________________________________ Role - Active. Based on interest and prior experience; IRB Status - approved (multiple projects); Skills - effort and interest | Radiology | Kidney cancer research projects | I focus on translational science and clinical research projects in kidney cancer. I have worked with approximately 20 summer students over the last 12 years in the Shapiro program and all students have been able to be co-authors on publications from these projects. If you are interested, email me and we can discuss projects based on your interests and experience. | 2 | Active. Based on interest and prior experience | variable depending on prior experience | effort and interest | approved (multiple projects) | Yes | Yes | Yes | Genetic Counseling students, PhD students | Unsure / Depends | Yes | Steve Hall Hall@urology.wisc.edu | E Jason Abel, abel@urology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudqSSOZ7PGDPFXRDwPfrcemjj3wn1j3G4tAze8EK1Lm2j4e4b0GK9Zfo3m5rSiQDuc | ||||||||
| mtlong@wisc.edu | Micah | Long | MD | Post-intensive care syndrome | 9.207.165.410 | Anesthesiology | Not currently interested or available for Non-Shapiro research mentoring of medical students | Post Intensive Care Syndrome (PICS): Post-intensive care syndrome (PICS) is a spectrum of psychologic/psychiatric and neurocognitive problems that occur commonly after critical illness of any cause. Patients can develop PTSD, depression and limitations in independence as a result of their illness. Limited information is known about PICS in certain subgroups of patients. We plan to study PICS in select groups of patients at UW, including liver transplant recipients, patients after complex cardiac surgery, and in patients who have suffered from cardiac arrest. The student will need to submit the research to the IRB including an approach to patient consent in these patient populations. Then, the student will be calling patients / families to perform a PICS screening battery over the telephone. This includes screening measure for MDD, PTSD and the like. We will be developing follow-up support for patients including phone-referrals, and potential support groups and expansion of the UW PICS clinic (housed in cardiology). An outline of these plans will be developed by the student. This student will also be a partner in the calcium after cardiac arrest research study, a separate study within the lab which may include chart review and data assessment. ____________________________________________________________________________ Role - Submit project to the IRB, consent patients / families, perform screening patient assessments over the telephone, develop longitudinal plans for PICS support.; IRB Status - Not in submission yet; Skills - None needed | Critical Care | John Dollerschell | dollerschell@wisc.edu | Anesthesiology | Critical Care & Cardiac Anesthesiology | Post Intensive Care Syndrome (PICS) | Post-intensive care syndrome (PICS) is a spectrum of psychologic/psychiatric and neurocognitive problems that occur commonly after critical illness of any cause. Patients can develop PTSD, depression and limitations in independence as a result of their illness. Limited information is known about PICS in certain subgroups of patients. We plan to study PICS in select groups of patients at UW, including liver transplant recipients, patients after complex cardiac surgery, and in patients who have suffered from cardiac arrest. The student will need to submit the research to the IRB including an approach to patient consent in these patient populations. Then, the student will be calling patients / families to perform a PICS screening battery over the telephone. This includes screening measure for MDD, PTSD and the like. We will be developing follow-up support for patients including phone-referrals, and potential support groups and expansion of the UW PICS clinic (housed in cardiology). An outline of these plans will be developed by the student. This student will also be a partner in the calcium after cardiac arrest research study, a separate study within the lab which may include chart review and data assessment. | 1 | Submit project to the IRB, consent patients / families, perform screening patient assessments over the telephone, develop longitudinal plans for PICS support. | Goal is high independence, though I require weekly shadowing, every other day check-ins and other meetings as needed. | None needed | Not in submission yet | No | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | No | Jeremy Sullivan (jasullivan@wisc.edu) | Micah Long, mtlong@wisc.edu -- Co-Mentor: John Dollerschell dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudEII2j4IH8Yc9g67w10mf3a-UxAh4py_qnlzp9VhWcJ4UwVavd4ePggTCTI4n8ySk | ||||
| bpgolden@medicine.wisc.edu | Blair | Golden | MD, MS | Assistant Professor | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Examining interdisciplinary communication regarding delirium: Despite its frequency and association with severe adverse clinical outcomes, delirium is commonly misdiagnosed or missed during hospitalizations for older adults. The goal of this project is to do a retrospective chart review identifying to what extent (and how) members of the clinical team communicate in the electronic health record regarding delirium. Opportunities will also be available to shadow on hospital medicine. The goal of the summer experience would be to gain authorship experience on a conference abstract and ultimately a publication. ____________________________________________________________________________ Role - The students role would be to conduct a chart review examining delirium documentation within the electronic health record. In addition, opportunities will be available to shadow occasionally within hospital medicine.; IRB Status - Approved; Skills - Basic Excel and Epic familiarity required. Prior qualitative and/or biostats research experience preferred. | Hospital Medicine | Examining interdisciplinary communication regarding delirium | Despite its frequency and association with severe adverse clinical outcomes, delirium is commonly misdiagnosed or missed during hospitalizations for older adults. The goal of this project is to do a retrospective chart review identifying to what extent (and how) members of the clinical team communicate in the electronic health record regarding delirium. Opportunities will also be available to shadow on hospital medicine. The goal of the summer experience would be to gain authorship experience on a conference abstract and ultimately a publication. | 2 | The students role would be to conduct a chart review examining delirium documentation within the electronic health record. In addition, opportunities will be available to shadow occasionally within hospital medicine. | Students should be able to conduct chart review independently after initial training. | Basic Excel and Epic familiarity required. Prior qualitative and/or biostats research experience preferred. | Approved | No | No (plan to use Dean's Office Funds) | Yes | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | No | N/A | Blair Golden, bpgolden@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudpTseMrGtK0SuRa7Wl4rw0zCsFGR5ibgXBjGjQ9yALIUm4X3mdyXPuxQzecat7K-g | |||||||||
| cthiessen@wisc.edu | Carrie | Thiessen | MD, PHD | Assistant Professor | Surgery | Not currently interested or available for Non-Shapiro research mentoring of medical students, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Ethics of deceased organ donation: We are employing qualitative interviews to assess the emotional and educational value of pre-procurement conversations between the donor surgery team and donor families. By the start of the summer, we will have transcripts for the initial interviews and will be beginning the process of data analysis. Participating in the project will teach you about ethical issues in transplantation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference. If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will be given the opportunity to shadow in the transplant clinic and attend donor and recipient selection committee meetings. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in in-person research team meetings once a week and weekly in-person individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings for up to two hours once a week. No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The ideal student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). ____________________________________________________________________________ Role - Researcher; IRB Status - Will be submitted February 2023, Approved prior to the summer; Skills - NA | Transplant | Medical History and Bioethics | Ethics of deceased organ donation | We are employing qualitative interviews to assess the emotional and educational value of pre-procurement conversations between the donor surgery team and donor families. By the start of the summer, we will have transcripts for the initial interviews and will be beginning the process of data analysis. Participating in the project will teach you about ethical issues in transplantation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference. If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will be given the opportunity to shadow in the transplant clinic and attend donor and recipient selection committee meetings. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in in-person research team meetings once a week and weekly in-person individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings for up to two hours once a week. No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The ideal student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | 1 | Researcher | High | NA | Will be submitted February 2023, Approved prior to the summer | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | SARAH R PAVAO |
Carrie Thiessen, cthiessen@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueiO7jSvDeTvHHDLQTYq74DAxihT6zJs4s8pJgJbHf2VLIpcJQeNP97qpgi4zq5KA8 | ||||||||
| cthiessen@wisc.edu | Carrie | Thiessen | MD, PHD | Assistant Professor | Surgery | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Ethics in living organ donor transplant: We are employing qualitative interviews to assess patient and healthcare provider attitudes toward a hypothetical living donor exchange program. By the start of the summer, we will have transcripts for the initial interviews and will be beginning the process of data analysis. Participating in the project will teach you about ethical issues in transplantation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference. If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will be given the opportunity to shadow in the transplant clinic and attend donor and recipient selection committee meetings. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in in-person research team meetings once a week and weekly in-person individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings for up to two hours once a week. No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The ideal student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). ____________________________________________________________________________ Role - Researcher; IRB Status - Approved; Skills - NA | Transplant | Medical History and Bioethics | Ethics in living organ donor transplant | We are employing qualitative interviews to assess patient and healthcare provider attitudes toward a hypothetical living donor exchange program. By the start of the summer, we will have transcripts for the initial interviews and will be beginning the process of data analysis. Participating in the project will teach you about ethical issues in transplantation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference. If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will be given the opportunity to shadow in the transplant clinic and attend donor and recipient selection committee meetings. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in in-person research team meetings once a week and weekly in-person individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings for up to two hours once a week. No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The ideal student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | 1 | Researcher | High | NA | Approved | Yes | Yes | Yes | MPH students, PhD students, UW undergraduates interested in research | No | No | SARAH R PAVAO |
Carrie Thiessen, cthiessen@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueFk1Y7aUspQeCeMx2NBOb3d9hCWnMXe4PVPvMHswL20xto-NQMIg9RDsZOKOgH3k0 | ||||||||
| whiting@ortho.wisc.edu | Paul | Whiting | M.D. | Associate Professor | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Trabecular Bone Score Correlation with Screw Cutout in Femoral Neck Fractures: Femoral neck fractures are common injuries, especially seen in elderly patients as a result of low energy falls. Risk factors for these fractures include female gender, decreased mobility, and low bone density. With an aging population, these fractures are becoming increasingly common. It is estimated that by 2030, there will be 300,000 hip fractures annually in the United States alone. Treatment for these injuries typically involves surgical fixation using three cannulated screws placed percutaneously. A known complication of this fixation method is screw cutout, meaning screw migration that can lead to perforation through the femoral head. Bone mineral density as determined by DXA and quantitative CT has been shown to correlate with screw pullout strength. Trabecular bone score (TBS), which is a measurement of bone microarchitecture rather than mineral density, has been found to correlate with vertebral body stiffness, and has recently been utilized in other anatomic locations. A recent study be Bernatz et al. found that TBS correlates more strongly to distal femur screw pullout strength than do DXA and quantitative CT. To our knowledge, no study has evaluated the correlation between TBS, DXA, and quantitative CT and screw cutout in femoral neck fractures treated with cannulated screws. Research question: Is trabecular bone score a better predictor of screw cutout in femoral neck fractures as compared to bone mineral density (DXA) and Hounsfield units (quantitative CT)? ____________________________________________________________________________ Role - We have 20 cadaveric femurs which we will utilize for this study. We will measure bone mineral density (DXA), CT Hounsfield units, and trabecular bone score in all 20 proximal femurs. The student will assist with data collection. We will then place screws through the femoral necks to simulate surgical fixation of a femoral neck fracture and work with our Biomechanics lab to create a model to simulate an axial load through the screw. The student will be involved with surgical instrumentation of the femur, data collection, and data analysis. The student will have the opportunity to produce an abstract and manuscript for this project following data collection and analysis.; IRB Status - N/A; Skills - The following skills are expected/required: - maintain database (i.e. Excel, REDCap) -meet with statistician to determine statistical tools that will be used to analyze the data -participate in abstract/manuscript preparation and submission | Trabecular Bone Score Correlation with Screw Cutout in Femoral Neck Fractures | Femoral neck fractures are common injuries, especially seen in elderly patients as a result of low energy falls. Risk factors for these fractures include female gender, decreased mobility, and low bone density. With an aging population, these fractures are becoming increasingly common. It is estimated that by 2030, there will be 300,000 hip fractures annually in the United States alone. Treatment for these injuries typically involves surgical fixation using three cannulated screws placed percutaneously. A known complication of this fixation method is screw cutout, meaning screw migration that can lead to perforation through the femoral head. Bone mineral density as determined by DXA and quantitative CT has been shown to correlate with screw pullout strength. Trabecular bone score (TBS), which is a measurement of bone microarchitecture rather than mineral density, has been found to correlate with vertebral body stiffness, and has recently been utilized in other anatomic locations. A recent study be Bernatz et al. found that TBS correlates more strongly to distal femur screw pullout strength than do DXA and quantitative CT. To our knowledge, no study has evaluated the correlation between TBS, DXA, and quantitative CT and screw cutout in femoral neck fractures treated with cannulated screws. Research question: Is trabecular bone score a better predictor of screw cutout in femoral neck fractures as compared to bone mineral density (DXA) and Hounsfield units (quantitative CT)? | 0 | We have 20 cadaveric femurs which we will utilize for this study. We will measure bone mineral density (DXA), CT Hounsfield units, and trabecular bone score in all 20 proximal femurs. The student will assist with data collection. We will then place screws through the femoral necks to simulate surgical fixation of a femoral neck fracture and work with our Biomechanics lab to create a model to simulate an axial load through the screw. The student will be involved with surgical instrumentation of the femur, data collection, and data analysis. The student will have the opportunity to produce an abstract and manuscript for this project following data collection and analysis. | Students will be expected to accomplish all of the above tasks and work toward accomplishing these components of the project with the resident. Appropriate guidance and direction will be provided (by the PI/co-investigators, research coordinator, and other research support staff) at the outset of the project and throughout the summer. Ongoing supervision/mentorship will be provided after the summer and throughout the process of abstract/manuscript submission, presentation, and publication. | The following skills are expected/required: - maintain database (i.e. Excel, REDCap) -meet with statistician to determine statistical tools that will be used to analyze the data -participate in abstract/manuscript preparation and submission | N/A | No | Yes | Yes | Not currently available to mentor other students | No | No | Heidi Ableidinger (Student Services Coordinator) - ableidinger@ortho.wisc.edu Gabrielle Kuhn (Ortho Trauma Research Coordinator) - otrc@ortho.wisc.edu | Paul Whiting, whiting@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnudZxThlfgOe35iRDMeVZy3l4LPH05v-0y5sIHoqUZIjNwhDdN3-nRJvwbYl8xLACNM | |||||||||
| whiting@ortho.wisc.edu | Paul | Whiting | M.D. | Associate Professor | 608 | Orthopedics and Rehabilitation | Not currently interested or available for Non-Shapiro research mentoring of medical students | Impact of Infection Control Interventions on Number of Door Openings in Spine Operating Rooms: Operating room (OR) traffic can be associated with increased risk of surgical infection. Simple interventions, such as signs and staff education, have been shown to impact the number of door openings in the OR. Last summer a research team investigated the impact of Avagard dispenser location as well as other interventions on the number of door openings in the OR during total joint arthroplasty procedures. The purpose of this project is to investigate the impact of Avagard dispenser location as well as other interventions on the number of door openings in the OR during spinal procedures at the UW University Hospital and East Madison Hospital. The student will quantify the number of door openings in spine operating rooms before and after implementation of interventions. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor). ____________________________________________________________________________ Role - Students will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission ; IRB Status - IRB application will need to be submitted.; Skills - The following skills are expected/required: - perform a literature search and compile a list of manuscript references - perform data collection - maintain database (i.e. Excel, REDCap) - meet with the statistician to determine the statistical tools that will be used to analyze the data - participate in abstract/manuscript preparation and submission | Trauma | Seth Williams, M.D. | swilliams@ortho.wisc.edu | Orthopedics and Rehabilitation | Spine and Trauma | Impact of Infection Control Interventions on Number of Door Openings in Spine Operating Rooms | Operating room (OR) traffic can be associated with increased risk of surgical infection. Simple interventions, such as signs and staff education, have been shown to impact the number of door openings in the OR. Last summer a research team investigated the impact of Avagard dispenser location as well as other interventions on the number of door openings in the OR during total joint arthroplasty procedures. The purpose of this project is to investigate the impact of Avagard dispenser location as well as other interventions on the number of door openings in the OR during spinal procedures at the UW University Hospital and East Madison Hospital. The student will quantify the number of door openings in spine operating rooms before and after implementation of interventions. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor). | 1 | Students will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission | Students will be expected to accomplish all of the above tasks and work toward accomplishing these components of the project independently. However, appropriate guidance and direction will be provided (by the PI/co-investigators, research coordinator, and other research support staff) at the outset of the project and throughout the summer. We will schedule weekly meetings with the PI and/or other investigators/research staff. The purpose of these meetings will be to monitor project progress. Ongoing supervision/mentorship will be provided after the summer and throughout the process of abstract/manuscript submission, presentation, and publication. | The following skills are expected/required: - perform a literature search and compile a list of manuscript references - perform data collection - maintain database (i.e. Excel, REDCap) - meet with the statistician to determine the statistical tools that will be used to analyze the data - participate in abstract/manuscript preparation and submission | IRB application will need to be submitted. | No | Yes | Yes | Not currently available to mentor other students | No | Yes | Heidi Ableidinger (Student Services Coordinator) - Ableidinger@ortho.wisc.edu Gabrielle Kuhn (Ortho Trauma Research Coordinator) - otrc@ortho.wisc.edu | Paul Whiting, whiting@ortho.wisc.edu -- Co-Mentor: Seth Williams, M.D. swilliams@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnufMMbcWwpGL8G_mRyjodY9-V7c_erFLE0CWO0jvEB3zyD-5BoTeSKjP7jNn2F0HXtQ | ||||
| ptiwari9@wisc.edu | Pallavi | Tiwari | PhD | Associate Professor, Departments of Radiology, Biomedical Engineering, Medical Physics Co-Director, Imaging and Radiation Sciences program, Carbone Cancer Center Co-Leader, Machine Learning in Medical Imaging (ML4MI) Initiative | Radiology | Shorter term projects | Outcome predictions in Stroke: Stroke is one of the leading causes of disability worldwide. The most common causes of stroke are brain bleed and obstruction in the arteries which lead to low oxygen supply to the surrounding tissues resulting in tissue death. Radiology scans (e.g., MRI and CT) can take in-depth images of the brain to visualize the affected area. To understand how to save and minimize this damage, we are using these radiology images and specialized AI computer code to model the effects of stroke and predict the damage outcome. Despite a lot of work being done to understand stroke-induced damage, its process, and prediction of the area affected by it, we still don’t have enough information to predict the post-damage effects. Our aim is to develop a model of prediction for post-stroke damage and complications. ____________________________________________________________________________ Role - ROI identification and segmentation; IRB Status - N/A; Skills - Clinical Knowledge and understanding of Stroke | Dr Marwa Ismail | ismail8@wisc.edu | Radiology | Outcome predictions in Stroke | Stroke is one of the leading causes of disability worldwide. The most common causes of stroke are brain bleed and obstruction in the arteries which lead to low oxygen supply to the surrounding tissues resulting in tissue death. Radiology scans (e.g., MRI and CT) can take in-depth images of the brain to visualize the affected area. To understand how to save and minimize this damage, we are using these radiology images and specialized AI computer code to model the effects of stroke and predict the damage outcome. Despite a lot of work being done to understand stroke-induced damage, its process, and prediction of the area affected by it, we still don’t have enough information to predict the post-damage effects. Our aim is to develop a model of prediction for post-stroke damage and complications. | 2 | ROI identification and segmentation | Clinical Knowledge and understanding of Stroke | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | No | Juhi Desai:jrdesai2@wisc.edu | Pallavi Tiwari, ptiwari9@wisc.edu -- Co-Mentor: Dr Marwa Ismail ismail8@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnuc1ah1GXC2TNLJFV59WnXvE0kbyglc9o00Dwk2TB1gbWbT3VDohvkQXaM-hGwIHwEM | ||||||||
| bschnapp@medicine.wisc.edu | Benjamin | Schnapp | MD MEd | Associate Residency Program Director, Associate Professor | Emergency Medicine | Not currently interested or available for Non-Shapiro research mentoring of medical students | Emergency Medicine resident clinical efficiency - does adding a medical student lend a hand?: Our project aims to assess how emergency medicine resident efficiency is affected by having an Acute Care Block medical student paired with them. We suspect that any additional work associated with having a student on-shift, such as teaching activities, may be offset by the student’s ability to help with important aspects of patient care (e.g., updating patients, calling consultants). We believe that our work will be important to medical schools and residency programs by attempting to determine how to best balance the needs of both resident and medical student learners in the fast-paced environment of the Emergency Department (ED), as well as non-academic clinical sites considering adding students. The study will be grounded in Cognitive Load Theory (CLT), a well-known framework involving how our brains process tasks. You can learn more about CLT here: https://www.nuemblog.com/blog/cognitive-load Through a retrospective data review of Electronic Medical Record (EMR) data, we will assess patients per hour (PPH) and Relative Value Units (RVUs) per hour during a resident’s second year when EM residents are paired with students and compare these values to shifts when these residents are working alone. We will also collect data on how fast patients were able to be dispositioned from the ED, patient acuity/complexity, and whether or not more patients required repeat ED visits. Our goal is to have a student assist us with preparing, reviewing and analyzing this data, and writing up this analysis into a manuscript for publication. Study Objectives: a. To assess whether pairing 2nd year EM residents with students increases or decreases their efficiency as measured by patients seen per hour and RVUs per hour. b. To assess whether pairing 2nd year EM residents with students is associated with differences in patient characteristics seen such as ESI levels, time to disposition and admit rate. c. To assess whether pairing 2nd year EM residents with students is associated with a change in quality metrics such as return ED visits or ICU upgrades. ____________________________________________________________________________ Role - Data analysis, manuscript writing; IRB Status - Exempt; Skills - Data analysis, manuscript writing | Corlin Jewell | cmjewell@medicine.wisc.edu | Emergency Medicine | Emergency Medicine resident clinical efficiency - does adding a medical student lend a hand? | Our project aims to assess how emergency medicine resident efficiency is affected by having an Acute Care Block medical student paired with them. We suspect that any additional work associated with having a student on-shift, such as teaching activities, may be offset by the student’s ability to help with important aspects of patient care (e.g., updating patients, calling consultants). We believe that our work will be important to medical schools and residency programs by attempting to determine how to best balance the needs of both resident and medical student learners in the fast-paced environment of the Emergency Department (ED), as well as non-academic clinical sites considering adding students. The study will be grounded in Cognitive Load Theory (CLT), a well-known framework involving how our brains process tasks. You can learn more about CLT here: https://www.nuemblog.com/blog/cognitive-load Through a retrospective data review of Electronic Medical Record (EMR) data, we will assess patients per hour (PPH) and Relative Value Units (RVUs) per hour during a resident’s second year when EM residents are paired with students and compare these values to shifts when these residents are working alone. We will also collect data on how fast patients were able to be dispositioned from the ED, patient acuity/complexity, and whether or not more patients required repeat ED visits. Our goal is to have a student assist us with preparing, reviewing and analyzing this data, and writing up this analysis into a manuscript for publication. Study Objectives: a. To assess whether pairing 2nd year EM residents with students increases or decreases their efficiency as measured by patients seen per hour and RVUs per hour. b. To assess whether pairing 2nd year EM residents with students is associated with differences in patient characteristics seen such as ESI levels, time to disposition and admit rate. c. To assess whether pairing 2nd year EM residents with students is associated with a change in quality metrics such as return ED visits or ICU upgrades. | 1 | Data analysis, manuscript writing | Moderate-high | Data analysis, manuscript writing | Exempt | No | Yes | Yes | Not currently available to mentor other students | Yes | No | Andrea Gilmore-Bykovskyi algilmore@medicine.wisc.edu | Benjamin Schnapp, bschnapp@medicine.wisc.edu -- Co-Mentor: Corlin Jewell cmjewell@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucGmR044of7PYADVaZfZG4ijzyLCTo58D6hTuUxR6ifR2V0wcp_TkwREGSXmmxTjyY | |||||||
| ptiwari9@wisc.edu | Pallavi | Tiwari | PhD | Associate Professor | 608 | Radiology | Shorter term projects | Predicting Glioma Patient Outcomes by Modeling Imaging and Clinical Data: The Integrated Diagnostic and Analytics Laboratory for Precision Medicine (https://idia.labs.wisc.edu/) works at the intersection of clinicians, data scientists, and engineers to develop informatics technologies for an improved understanding of challenging neurologic diseases and disorders. This study focuses on glioma patients and aims to model survival risk utilizing machine learning techniques to integrate radiology, histology, and omics data. By recognizing patterns in patient data, the developed models may offer insight into glioma behavior that can provide clinicians with supplemental information to improve patient diagnosis, prognosis, and treatment selection. A good fit for this project would be a student interested in radiology or pathology and exploring medical applications of artificial intelligence. Students involved will develop their understanding of glioma presentation, image analysis methods, statistical testing, and basic logistic modeling. Image analysis will include training to identify glioma tumors and features from MRI scans or histology slide images with guidance from related experts and the use of relevant software. The option to work on more advanced applications of machine learning topics is available to interested students. Beyond opportunities inherent to the project, the lab is within the Department of Radiology which also offers several unique learning experiences to student researchers. These can include small group mentoring sessions, faculty lectures, clinical shadowing, and potential financial support for meetings. Please reach out if you are interested in learning more about the project! ____________________________________________________________________________ Role - Brain tumor image analysis and annotation; data analysis and statistical modeling; develop knowledge in glioma presentation, outcomes, and research; IRB Status - N/A; Skills - None are required. Necessary skills will be taught during the project. | Medical Physics | Dr. Marwa Ismail, Scientist I | ismail8@wisc.edu | Radiology | Predicting Glioma Patient Outcomes by Modeling Imaging and Clinical Data | The Integrated Diagnostic and Analytics Laboratory for Precision Medicine (https://idia.labs.wisc.edu/) works at the intersection of clinicians, data scientists, and engineers to develop informatics technologies for an improved understanding of challenging neurologic diseases and disorders. This study focuses on glioma patients and aims to model survival risk utilizing machine learning techniques to integrate radiology, histology, and omics data. By recognizing patterns in patient data, the developed models may offer insight into glioma behavior that can provide clinicians with supplemental information to improve patient diagnosis, prognosis, and treatment selection. A good fit for this project would be a student interested in radiology or pathology and exploring medical applications of artificial intelligence. Students involved will develop their understanding of glioma presentation, image analysis methods, statistical testing, and basic logistic modeling. Image analysis will include training to identify glioma tumors and features from MRI scans or histology slide images with guidance from related experts and the use of relevant software. The option to work on more advanced applications of machine learning topics is available to interested students. Beyond opportunities inherent to the project, the lab is within the Department of Radiology which also offers several unique learning experiences to student researchers. These can include small group mentoring sessions, faculty lectures, clinical shadowing, and potential financial support for meetings. Please reach out if you are interested in learning more about the project! | 2 | Brain tumor image analysis and annotation; data analysis and statistical modeling; develop knowledge in glioma presentation, outcomes, and research | None are required. Necessary skills will be taught during the project. | N/A | Yes | No (plan to use Dean's Office Funds) | Yes | PhD students, UW undergraduates interested in research | No | No | Olivia Krebs (okrebs@wisc.edu), Stephen Craig (sccraig2@wisc.edu) | Pallavi Tiwari, ptiwari9@wisc.edu -- Co-Mentor: Dr. Marwa Ismail, Scientist I ismail8@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnueN1oF9RTP_iYKckS0MXY_1RAwWwCaEn8XB7s4ufdZontgoEzgUV5RopWd4pngxhfs | ||||||
| chiu@surgery.wisc.edu | Alexander | Chiu | MD MPH | Assistant Professor | Surgery | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Timely access to surgical care: Disparities in surgical care are well documented, and one heavily contributory factor lay in access to timely and appropriate care. This is particularly true for endocrine diseases that can be cured surgically, as they in general are underdiagnosed, particularly so for those in traditionally marginalized communities. This project will look into studying where the areas of delayed diagnosis and referral are happening using both institutional and national databases and to develop interventions to help mitigate these issues. ____________________________________________________________________________ Role - Student's role will be as much as they want to take on. Institutional data is readily available, and a student will be able to help create and craft the dataset, manage and analyze the data, and package the results into a scholarly article or presentation. The student will also have access to mentorship from the entire Endocrine Surgery Division to help in both career and educational guidance along with research mentorship.; IRB Status - IRB is approved; Skills - Introduction to statistics is beneficial but not necessary | Endocrine Surgery | Timely access to surgical care | Disparities in surgical care are well documented, and one heavily contributory factor lay in access to timely and appropriate care. This is particularly true for endocrine diseases that can be cured surgically, as they in general are underdiagnosed, particularly so for those in traditionally marginalized communities. This project will look into studying where the areas of delayed diagnosis and referral are happening using both institutional and national databases and to develop interventions to help mitigate these issues. | 1 | Student's role will be as much as they want to take on. Institutional data is readily available, and a student will be able to help create and craft the dataset, manage and analyze the data, and package the results into a scholarly article or presentation. The student will also have access to mentorship from the entire Endocrine Surgery Division to help in both career and educational guidance along with research mentorship. | Introduction to statistics is beneficial but not necessary | IRB is approved | No | No (plan to use Dean's Office Funds) | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Yes | n/a | Alexander Chiu, chiu@surgery.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnud4x9rOAptRH6BeMV45mfcbYfR3998eonuoKS5M1HVVkyHtxbVxep9kp8ll0vOQXMo | ||||||||||
| npulia@wisc.edu | Nicole | Rogus-Pulia | PhD | Assistant Professor/Speech-Language Pathologist | 6.083.472.368 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Dysphagia Management in Patients with Dementia: The Swallowing and Salivary Bioscience Laboratory is a translational research program focused on identifying and characterizing the factors contributing to swallowing disorders in persons with Alzheimer’s disease and Related Dementias (AD/ADRD). Patients with AD/ADRD frequently develop difficulty swallowing (dysphagia), and there are various approaches to managing swallowing disorders caused by neurodegenerative disease. This project involves performing chart abstractions of information related to dysphagia, swallowing recommendations, and referrals for swallowing evaluation for inpatients and outpatients with AD/ADRD at UW, followed by examination of the influence of other healthcare-related factors in clinical decision-making. This information will be used to evaluate the approaches to dysphagia management in dementia, as well as examine health disparities among this population. Swallowing and Salivary Bioscience Laboratory: https://ssbl.wisc.edu ____________________________________________________________________________ Role - Chart review and abstract variables from the electronic medical record; code for themes; data analysis; create presentation/manuscript; IRB Status - Approved; Skills - Good communicator, motivated | Geriatrics | Raele Robison | rrobison@wisc.edu | Medicine | Geriatrics | Dysphagia Management in Patients with Dementia | The Swallowing and Salivary Bioscience Laboratory is a translational research program focused on identifying and characterizing the factors contributing to swallowing disorders in persons with Alzheimer’s disease and Related Dementias (AD/ADRD). Patients with AD/ADRD frequently develop difficulty swallowing (dysphagia), and there are various approaches to managing swallowing disorders caused by neurodegenerative disease. This project involves performing chart abstractions of information related to dysphagia, swallowing recommendations, and referrals for swallowing evaluation for inpatients and outpatients with AD/ADRD at UW, followed by examination of the influence of other healthcare-related factors in clinical decision-making. This information will be used to evaluate the approaches to dysphagia management in dementia, as well as examine health disparities among this population. Swallowing and Salivary Bioscience Laboratory: https://ssbl.wisc.edu | 1 | Chart review and abstract variables from the electronic medical record; code for themes; data analysis; create presentation/manuscript | Moderate | Good communicator, motivated | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently available to mentor other students | No | Unsure / Depends | Sara Gustafson - segustafson@wisc.edu | Nicole Rogus-Pulia, npulia@wisc.edu -- Co-Mentor: Raele Robison rrobison@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdCag337tFe4KL9_6rQ-AEogBkv98RfZjTzQ6DxypNB_Z0sMQ/viewform?edit2=2_ABaOnucxFDaKMOpNSdu4ZVVQkfxkyeXrVxPm7K4a2kwRx9Nyvn31dwvFvJgwM_hqvGPQguk | ||||
| lschnapp@medicine.wisc.edu | Lynn | Schnapp | MD | Professor, Chair of Medicine | 608 | Medicine | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity, Willing to work with interested students to develop an appropriate research experience | Mechanisms in lung injury, inflammation and repair: Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn ____________________________________________________________________________ Role - The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab.; IRB Status - n/a; Skills - Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | Pulmonary and Critical Care Medicine | Cell and Regenerative Biology | Carole Wilson, Research Associate Professor | cwilson@medicine.wisc.edu | Medicine | Pulmonary and Critical Care Medicine | Mechanisms in lung injury, inflammation and repair | Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn | 1 | The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab. | We can tailor the project to the student’s interests and aptitude. The student would work closely with lab personnel. | Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | n/a | Yes | Yes | Yes | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | 1. Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. Chest. 1;146(6):1543-53. 2014. PMC4251616 2. Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G. CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 308(8):L759-65. 2015 3. Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methe BA, Kaminski N, Sandhaus RA, GRADS Alpha-1 Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc. 12(10):1551-60. 2015. PMC4627425. *listed collaborator 4. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 12(10):1561-71 2015. PMID: 26193069. *listed collaborator 5. Gharib SA, Malur A, Huizar I, Barna BP, Kavuru MS, Schnapp LM*, Thomassen MJ*. Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 17(1):93. 2016 *Shared senior authorship. 6. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM*, Gharib SA*. Widespread activation of immunity and pro‐inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiological Reports. 4(8) pii: e12756. 2016. PMC4848721. *Shared senior authorship. 7. Attia EF, Jolley SE, Crothers K, Schnapp LM*, Liles WC*. Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS One. 11(2):e0149687. 2016 *Shared senior authorship. 8. Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM. Ablation of Pericyte-like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. Am J Respir Cell Mol Biol. 56(2):160-167 2017. PMC5359647. (Featured in “Red Alerts” highlighted articles) 9. Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA. Lung pericyte-like cells are functional immune sentinel cells. Am J Physiol Lung Cell Mol Physiol. 312(4): L556-L567. 2017. PMC5407093. (Chosen for “APSselect” highlight) 10. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Strange S, for QUANTUM-1 Investigators. Serum proteins associated with emphysema progression in severe alpha-1 antitrypsin deficiency. Chronic Obstr Pulm Dis. 4(3): 204-216. 2017 11. Mohan A, Malur A, McPeek M, Barna BP, Schnapp LM*, Thomassen MJ*, Gharib SA*. Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis. Am J Physiol Lung Cell Mol Physiol. 314(4):L617-L625, 2017. PMC5966779 *Shared senior authorship. 12. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV Infection on Alpha-1 Antitrypsin in the Lung. Am J Physiol Lung Cell Mol Physiol. 314(4):L583-L592. 2017. PMC5966776 13. Hung CF, Wilson CL, Chow YH, Schnapp LM. Role of integrin alpha8 in murine model of lung fibrosis. PLoS One. 13(5):e0197937. 2018. PMC5973593. 14. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 218(12):1995-2005, 2018. 15. Wilson CL, Stephenson SE, Higuero JP, Feghali-Bostwick C, Hung CF, Schnapp LM Characterization of human PDGFRβ-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18. doi: 10.1152/ajplung.00289.2018. PMID:30335500 16. Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group. The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. Am J Med Sci. 2019 May;357(5):405-410. PubMed PMID: 31010467. 17. Hung CF, Wilson CL, Schnapp LM. Pericytes in the Lung. Adv Exp Med Biol. 2019;1122:41-58. PubMed PMID: 30937862. 18. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest 2021. 19. Stephenson SE, Wilson CL, Bond NG, Kaur A, Alvarez X, Midkiff CC, Schnapp LM. Pericytes as novel targets for HIV/SIV infection in the lung. Am J Physiol Lung Cell Mol Physiol 2020; 319: L848-l853. 20. Mohan A, Neequaye N, Malur A, Soliman E, McPeek M, Leffler N, Ogburn D, Tokarz DA, Knudson W, Gharib SA, Schnapp LM, Barna BP, Thomassen MJ. Matrix Metalloproteinase-12 Is Required for Granuloma Progression. Front Immunol 2020; 11: 553949. | Yes | jewerndli@medicine.wisc.edu | Lynn Schnapp, lschnapp@medicine.wisc.edu -- Co-Mentor: Carole Wilson, Research Associate Professor cwilson@medicine.wisc.edu | ||||
| huy.dinh@wisc.edu | Huy | Dinh | Ph.D. | Assistant Professor | 6.082.632.890 | Oncology | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Bioinformatics analysis of cancer immunology data: Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early cancer detection and immunotherapy response and potential targets for cancer treatment. Thus, we will train prospective students to perform statistical and computational analyses to address biological questions in cancer immunology. They will work with graduate students and postdocs on current projects in the lab studying immunology in multiple cancer types. Their analysis will be acknowledged by authorship in the lab's manuscripts. Website: dinhlab.oncology.wisc.edu ____________________________________________________________________________ Role - Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project.; IRB Status - N/A; Skills - Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | Biostatistics and Medical Informatics | Bioinformatics analysis of cancer immunology data | Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early cancer detection and immunotherapy response and potential targets for cancer treatment. Thus, we will train prospective students to perform statistical and computational analyses to address biological questions in cancer immunology. They will work with graduate students and postdocs on current projects in the lab studying immunology in multiple cancer types. Their analysis will be acknowledged by authorship in the lab's manuscripts. Website: dinhlab.oncology.wisc.edu | 2 | Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project. | N/A | Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | N/A | No | No (plan to use Dean's Office Funds) | N/A | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | N/A | Huy Dinh, huy.dinh@wisc.edu -- Co-Mentor: | |||||||||
| dlamming@medicine.wisc.edu | Dudley | Lamming | Ph.D. | Associate Professor | 608 | Medicine | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | Improving metabolic health through reduced consumption of specific dietary amino acids: Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ ____________________________________________________________________________ Role - The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation.; IRB Status - Approved; Skills - None | Endocrinology, Diabetes and Metabolism | Associate Professor Dawn Davis, MD, PhD | dbd@medicine.wisc.edu | Medicine | Endocrinology, Diabetes and Metabolism | Improving metabolic health through reduced consumption of specific dietary amino acids | Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ | 1 | The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation. | Medium - students will be co-mentored by Dr. Davis and will be supervised in the clinic by Dr. Rowan Karaman, a VA Advanced Fellow and UW Instructor, but will also work independently. Similarly, students will be trained in any mouse or cell culture work but will be expected to complete experiments independently. Students will analyze data and prepare presentations. | None | Approved | Yes | The Department of Medicine routinely provides this funding for Shapiro students. | Yes | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Fontana et al, 2016, Cell Reports, PMID: 27346343; Cummings et al, 2018, J Physiology, PMID: 29266268; additional manuscripts under review | Yes | N/A | Dudley Lamming, dlamming@medicine.wisc.edu -- Co-Mentor: Associate Professor Dawn Davis, MD, PhD dbd@medicine.wisc.edu | |||||
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Non-Shapiro Opportunities | Project Information | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | blank 1 | Mentor Information | Response |