Please note that ALL projects with open slots are available to Shapiro applicants. “Non-Shapiro Opportunities” refer to opportunities available for medical students interested in a shorter term (non-summer) projects and yearlong projects.
Summer Research 2022
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Non-Shapiro Opportunities | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Have you completed any mentoring training? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | Option | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Project Information | Mentor Information | Response URL | Test Email Address |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/12/2021 | abdelsayed@wisc.edu | Alaa | Abd-Elsayed | MD, MPH, FASA | Medical Director, UW Health Pain Services | 2.163.461.739 | Anesthesiology | Pain Medicine | Peripheral nerve stimulation for treating pain | Peripheral nerve stimulation is an advanced technology for treating chronic pain conditions. We were one of the first centers in the country to perform this procedure and we wish to collect this data on all patients we treated so far to identify outcomes. https://anesthesia.wisc.edu/research/researchers/abd-elsayed-laboratory/ | 2 | Data collection from electronic medical records and writing article | Ability to collect data | Will obtain an exemption | No | Yes, provided by the Department of Anesthesia | Yes | Shorter term projects | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | Jeremy Sullivan, PhD. jasullivan@wisc.edu | Unsure / Depends | Peripheral nerve stimulation for treating pain: Peripheral nerve stimulation is an advanced technology for treating chronic pain conditions. We were one of the first centers in the country to perform this procedure and we wish to collect this data on all patients we treated so far to identify outcomes. https://anesthesia.wisc.edu/research/researchers/abd-elsayed-laboratory/ ____________________________________________________________________________ Role - Data collection from electronic medical records and writing article; IRB Status - Will obtain an exemption; Skills - Ability to collect data | Alaa Abd-Elsayed, abdelsayed@wisc.edu -- Co-Mentor: | ||||||||||
| 08/12/2021 | abel@urology.wisc.edu | E Jason | Abel | MD | Associate Professor | 6.086.928.256 | Urology | kidney cancer projects | I have several clinical and translational projects focused on kidney cancer that would be great for summer Shapiro students. I have mentored students in this program for 11 years and all students have been able to publish results. Email me if you are interested and we can discuss specific projects based on your interests and prior experience. | 1 | collect and analyze data, present data in abstract, meeting or manuscript | variable | enthusiasm and strong work ethic | approved | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Genetic Counseling students, MPH students, PhD students, UW undergraduates interested in research | Unsure / Depends | No | Denise Mussehl mussehl@urology.wisc.edu | No | kidney cancer projects: I have several clinical and translational projects focused on kidney cancer that would be great for summer Shapiro students. I have mentored students in this program for 11 years and all students have been able to publish results. Email me if you are interested and we can discuss specific projects based on your interests and prior experience. ____________________________________________________________________________ Role - collect and analyze data, present data in abstract, meeting or manuscript; IRB Status - approved; Skills - enthusiasm and strong work ethic | E Jason Abel, abel@urology.wisc.edu -- Co-Mentor: | ||||||||||
| 10/01/2022 | majid.afshar@wisc.edu | Majid | Afshar | MD, MSCR | Assistant Professor | 13.125.459.462 | Medicine | Pulmonary and Critical Care | Biostatistics and Medical Informatics | Anoop | Building a Substance Use Data Commons for Public Health Informatics | This proposal aims to establish a comprehensive Substance Use Data Commons that links health system data with public health agency data for a platform designed for machine learning activities to provide health system and public policy leaders guidance on clinical interventions and regional health policy change of opioid overdose prevention. Ultimately, the tools developed from this proposal will be used to support collaborations that bring together expertise in biomedicine, data management, and artificial intelligence and machine learning (AI/ML) to make NIH-supported data useful and usable for AI/ML analytics. The student will learn to access the data using our novel Platform X cloud service and help build the data dictionaries for variable input into machine learning models. Our website is at: https://www.medicine.wisc.edu/apcc/icu-data-science-lab | 0 | Health information exchange user and data dictionary builder | No | Prefer any background in programming or cloud computing skills | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity, Doctorate and masters students in data science | MPH students, PhD students, UW undergraduates interested in research | No | mkoguss@medicine.wisc.edu; mayampurath@wisc.edu | Yes | Building a Substance Use Data Commons for Public Health Informatics: This proposal aims to establish a comprehensive Substance Use Data Commons that links health system data with public health agency data for a platform designed for machine learning activities to provide health system and public policy leaders guidance on clinical interventions and regional health policy change of opioid overdose prevention. Ultimately, the tools developed from this proposal will be used to support collaborations that bring together expertise in biomedicine, data management, and artificial intelligence and machine learning (AI/ML) to make NIH-supported data useful and usable for AI/ML analytics. The student will learn to access the data using our novel Platform X cloud service and help build the data dictionaries for variable input into machine learning models. Our website is at: https://www.medicine.wisc.edu/apcc/icu-data-science-lab ____________________________________________________________________________ Role - Health information exchange user and data dictionary builder; IRB Status - Approved; Skills - Prefer any background in programming or cloud computing skills | Majid Afshar, majid.afshar@wisc.edu -- Co-Mentor: Anoop | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufs2hoRlJX5w8OYbd0YI0cE8lIkq_8Aj3q0l-YZkxebNTGfo6XpZM6qOsFr69ByFfc | |||||||
| 24/01/2022 | nahmad@dermatology.wisc.edu | Nihal | Ahmad | PhD | Professor | 608 | Dermatology | Gagan Chhabra | gchhabra@dermatology.wisc.edu | Dermatology | Role of MZB1 in melanoma | Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. Despite all the recent advancements in melanoma treatment, most of the patients fail to achieve durable tumor regression, and demonstrate metastasis and recurrence due to acquired resistance against available therapies. Thus, novel mechanism-based approaches are urgently required for melanoma management. Novel immune-related targets hold promise to improve melanoma treatment and patient survival. Using bioinformatics, we previously identified key immune-related molecules that are differentially expressed in metastatic melanoma and have significant correlation with patient survival. Further, employing melanoma tissue microarray (TMA) analysis as well as multiple melanoma cell lines, we determined that the MZB1, (Marginal zone B and B1 cell specific protein), an endoplasmic reticulum (ER)-localized B cell-specific cochaperone protein is significantly overexpressed in melanoma tissues and human melanoma cell lines. However, the role and functional significance of MZB1 is not known in melanoma. In this project, we will determine the effects of forced overexpression and knockout of MZB1 in multiple melanoma cell lines. Specifically, we will determine the effects of MZB1 modulation on cell proliferation, colony formation, cell cycle, migration and invasion as well as on markers of proliferation and survival. | 1 | Student will work in the above project and study the role and functional significance of MZB1 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cells lines, cell proliferation, invasion and migration assays, cell cycle analysis, and RT-qPCR and Simple Western techniques for gene and protein expression analyses. | Knowledge of cell culture and basic laboratory techniques is preferred but not required. | N/A | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | PhD students | Unsure / Depends | Mary Poellinger |
No | Role of MZB1 in melanoma: Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. Despite all the recent advancements in melanoma treatment, most of the patients fail to achieve durable tumor regression, and demonstrate metastasis and recurrence due to acquired resistance against available therapies. Thus, novel mechanism-based approaches are urgently required for melanoma management. Novel immune-related targets hold promise to improve melanoma treatment and patient survival. Using bioinformatics, we previously identified key immune-related molecules that are differentially expressed in metastatic melanoma and have significant correlation with patient survival. Further, employing melanoma tissue microarray (TMA) analysis as well as multiple melanoma cell lines, we determined that the MZB1, (Marginal zone B and B1 cell specific protein), an endoplasmic reticulum (ER)-localized B cell-specific cochaperone protein is significantly overexpressed in melanoma tissues and human melanoma cell lines. However, the role and functional significance of MZB1 is not known in melanoma. In this project, we will determine the effects of forced overexpression and knockout of MZB1 in multiple melanoma cell lines. Specifically, we will determine the effects of MZB1 modulation on cell proliferation, colony formation, cell cycle, migration and invasion as well as on markers of proliferation and survival. ____________________________________________________________________________ Role - Student will work in the above project and study the role and functional significance of MZB1 in melanoma. Depending on the skills and interests, student will be involved in cell culture techniques of human melanoma cells lines, cell proliferation, invasion and migration assays, cell cycle analysis, and RT-qPCR and Simple Western techniques for gene and protein expression analyses. ; IRB Status - N/A; Skills - Knowledge of cell culture and basic laboratory techniques is preferred but not required. | Nihal Ahmad, nahmad@dermatology.wisc.edu -- Co-Mentor: Gagan Chhabra gchhabra@dermatology.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudQq1sLvVwdtEPAmhzeSCZ5s9RWlvdf9X8s86QeBdcJdJdkqUL9MSkFBaUl9ZZZHTU | ||||||||
| 03/01/2022 | mralbert@wisc.edu | Mark | Albertini | M.D. | Professor | 608 | Medicine | Hematology/Medical Oncology/Palliative Care | Cindy Zuleger, PhD. | clz@medicine.wisc.edu | Medicine | Hematology/Medical Oncology/Palliative Care | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma | Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. | 0 | The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin. | Ability to independently review the literature related to the research project is required. While mentoring is provided in the lab, progressing to independence with laboratory analyses is expected. | Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | N/A | VA Merit Grant | Plan to apply to the Dept of Medicine for stipend support or use the Dean's Office Funds. I do not have separate funding to cover 50% of the Shapiro summer student's stipend. | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students, UW undergraduates interested in research | No | Dr. Cindy Zuleger: clz@medicine.wisc.edu | No | Administration of intratumoral immunocytokine to activate immune rejection of spontaneous canine melanoma: Canine malignant melanoma provides a clinically relevant, large animal model to study melanoma immunotherapy as it is similar to human melanoma with metastasis occurring via lymphatics or blood vessels to regional lymph nodes, lungs, liver, brain, and kidney. Further, companion canines develop melanoma spontaneously in the setting of an intact immune system, are of various ages, mixed gender, and share similar environmental exposures with their human counterparts. Thus, canine melanoma provides an informative model in which to investigate melanoma immunotherapies for subsequent human trials. The Shapiro project involves molecular and cellular immune analyses in canines as part of a VA Merit award to investigate intratumoral (IT) injection of hu14.18-Interleukin-2 (IL2) immunocytokine (IC), a recombinant fusion protein linking the GD2 disialoganglioside-reactive monoclonal antibody hu14.18 with IL2, in dogs with spontaneous melanoma. IT-IC leverages the tumor's mutated neoantigens and converts the injected tumor into an autologous vaccine. The project also involves participation in analysis of melanoma patients being evaluated in the University of Wisconsin Carbone Cancer Center (UWCCC) protocol #UW16134 entitled “Phase I/II Trial of Intratumoral Administration of Hu14.18-IL2, with Local Radiation, Nivolumab and Ipilimumab in Subjects with Advanced Melanoma”. ____________________________________________________________________________ Role - The student will be involved with the processing of canine blood samples as well as cellular and/or flow cytometry and/or molecular immune assay development using samples from normal dogs and analyses of dogs with melanoma participating in a clinical trial that involves intratumoral injection of hu14.18-IL2 immunocytokine (IC) into spontaneous melanoma tumors. In addition to activities in the laboratory, the student will attend the weekly melanoma clinic as well as the melanoma tumor board and melanoma research meetings. The student will also participate in evaluating melanoma patients in ongoing melanoma clinical trials at the University of Wisconsin.; IRB Status - N/A; Skills - Skills involving sterile tissue culture and/or flow cytometry and/or molecular biology assays are required. Prior experience with cellular and/or molecular immunology is recommended. | Mark Albertini, mralbert@wisc.edu -- Co-Mentor: Cindy Zuleger, PhD. clz@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudWq7O0GiAtwr7X64pA1kxjvSKYXK76NDZgETloNTOYxpMGkqIVTyYjrKiDw7rK0g8 | |||||
| 09/12/2021 | raalexanian@medicine.wisc.edu | Ruben | Alexanian | MD | Assistant Professor | 6.085.093.875 | Medicine | Interventional Cardiology | Tissue Engineering Heart Valves | Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, either surgically, which imposes the use of indefinite therapeutic anticoagulation when a mechanical valve is utilized; or more recently transcatheter bioprosthetic valve replacement, hindered by long-term valve durability. Ectopic calcification is the main cause of failure of bioprosthetic valves as a result of cytotoxic effects of crosslinking agents (xenografts), tissue alterations caused by cryopreservation/thawing (allografts), graft-versus host rejection, and imperfections in bioprosthetic valve hemodynamics leading to tissue injury and infiltration of innate immune cells implicated in valve degeneration. Bioengineered, stem cell derived, heart valve scaffolds with or without autologous cells may provide an alternative to current mechanical and bioprosthetic valve implants, with reduced propensity for both thrombosis and calcification. The proposed study will utilize human pluripotent derived valve interstitial cells combined with decellularized valve extracellular matrix to construct a bioengineered autologous heart valve scaffold resistant to premature dystrophic calcification. These bioengineered scaffolds will be sutured unto a stented construct in collaboration with a commercially available valve companies to produce a functional tri-leaflet valve, which will be tested in animal models. | 1 | The qualified candidate will conduct bench top research including isolating aortic valve leaflets from pig hearts followed by chemical de-cellularization and re-celluarization utilizing pluripotent derived cells. | High | basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students, UW undergraduates interested in research | n/a | Yes | n/a | Yes | Tissue Engineering Heart Valves: Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, either surgically, which imposes the use of indefinite therapeutic anticoagulation when a mechanical valve is utilized; or more recently transcatheter bioprosthetic valve replacement, hindered by long-term valve durability. Ectopic calcification is the main cause of failure of bioprosthetic valves as a result of cytotoxic effects of crosslinking agents (xenografts), tissue alterations caused by cryopreservation/thawing (allografts), graft-versus host rejection, and imperfections in bioprosthetic valve hemodynamics leading to tissue injury and infiltration of innate immune cells implicated in valve degeneration. Bioengineered, stem cell derived, heart valve scaffolds with or without autologous cells may provide an alternative to current mechanical and bioprosthetic valve implants, with reduced propensity for both thrombosis and calcification. The proposed study will utilize human pluripotent derived valve interstitial cells combined with decellularized valve extracellular matrix to construct a bioengineered autologous heart valve scaffold resistant to premature dystrophic calcification. These bioengineered scaffolds will be sutured unto a stented construct in collaboration with a commercially available valve companies to produce a functional tri-leaflet valve, which will be tested in animal models. ____________________________________________________________________________ Role - The qualified candidate will conduct bench top research including isolating aortic valve leaflets from pig hearts followed by chemical de-cellularization and re-celluarization utilizing pluripotent derived cells.; IRB Status - N/A; Skills - basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred | Ruben Alexanian, raalexanian@medicine.wisc.edu -- Co-Mentor: | |||||||||
| 10/02/2022 | kantony@wisc.edu | Kathleen | Antony | MD, MSCI | Assistant Professor, Physician | 6.084.175.971 | Obstetrics & Gynecology | Maternal-Fetal Medicine | Mihaela Bazalakova | mbazalakova@wisc.edu | Neurology | Sleep Medicine | Barriers to Sleep Apnea Testing During Pregnancy: A Survey and Interview of Pregnant People referred for sleep tests who did not complete diagnostic testing | The purpose of this project is to interview women who screened positive for sleep apnea who were referred for diagnostic testing who did not complete the testing. We are seeking their perspectives, preferences, and experiences with the sleep center and to seek input on how to improve completion rates for diagnostic testing. This will be achieved via a structured survey followed by a brief structured interview. | 0 | The student’s role is to: 1-Use existing lists of past patients referred for diagnostic sleep testing during their pregnancy who did not complete diagnostic testing during their pregnancy. 2- Perform a brief chart review of the obstetric discharge summary to ensure that calling the patient is low-risk and unlikely to trigger a significant stress response. 3-Call the most recent telephone number and request permission to interview about experiences. 4-The telephone call will be recorded. This recording will be used to type a transcript which will be reviewed by obstetric care providers (the PI) to identify themes for qualitative analysis, if relevant. 5-These results would be eligible to be written up and reported upon in an abstract submitted to local and national meetings and a manuscript would be eligible for publication, likely in a smaller (lower impact but PubMed cited) journal. Abstract deadline would be either early August or early October (two potential meetings) 6- The student would have the opportunity to be first author on abstracts and potentially a manuscript if the student writes the first draft and is available for editing. (Deadline at the student’s convenience, but would be of student’s interest to finish prior to clinical rotations due to time constraints) | We expect this student to be comfortable calling patients on a provided telephone number and performing a recorded interview. Student will also transcribe the interview and enter quantitative/ likert responses into REDCap. To the degree that they are comfortable, they will also assist with or perform analyses, write the abstract, and manuscript. | Can learn to use REDCap via online videos. Can also learn qualitative analyses. | We are seeking a QI exemption. The database used is approved for both QI and IRB related projects. We will seek a QI exemption for this project | No | Yes | Yes | Generally interested but there are some current restrictions in place limiting these options | Not currently available to mentor other students | No | Andrea Zorbas azorbas@wisc.edu | Yes | Barriers to Sleep Apnea Testing During Pregnancy: A Survey and Interview of Pregnant People referred for sleep tests who did not complete diagnostic testing: The purpose of this project is to interview women who screened positive for sleep apnea who were referred for diagnostic testing who did not complete the testing. We are seeking their perspectives, preferences, and experiences with the sleep center and to seek input on how to improve completion rates for diagnostic testing. This will be achieved via a structured survey followed by a brief structured interview. ____________________________________________________________________________ Role - The student’s role is to: 1-Use existing lists of past patients referred for diagnostic sleep testing during their pregnancy who did not complete diagnostic testing during their pregnancy. 2- Perform a brief chart review of the obstetric discharge summary to ensure that calling the patient is low-risk and unlikely to trigger a significant stress response. 3-Call the most recent telephone number and request permission to interview about experiences. 4-The telephone call will be recorded. This recording will be used to type a transcript which will be reviewed by obstetric care providers (the PI) to identify themes for qualitative analysis, if relevant. 5-These results would be eligible to be written up and reported upon in an abstract submitted to local and national meetings and a manuscript would be eligible for publication, likely in a smaller (lower impact but PubMed cited) journal. Abstract deadline would be either early August or early October (two potential meetings) 6- The student would have the opportunity to be first author on abstracts and potentially a manuscript if the student writes the first draft and is available for editing. (Deadline at the student’s convenience, but would be of student’s interest to finish prior to clinical rotations due to time constraints) ; IRB Status - We are seeking a QI exemption. The database used is approved for both QI and IRB related projects. We will seek a QI exemption for this project; Skills - Can learn to use REDCap via online videos. Can also learn qualitative analyses. | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: Mihaela Bazalakova mbazalakova@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnude46We2I3607WW2jfXf6ukd9bok_g3dh7gT-npYSG5XAenUvnQJZVHJb03nKQG4RE | |||||
| 10/02/2022 | kantony@wisc.edu | Kathleen | Antony | MD, MSCI | Associate Professor | 6.084.175.971 | Obstetrics & Gynecology | Maternal-Fetal Medicine | Cesarean Incision Bupivacaine Injections: Do they reduce post-cesarean pain and opioid use? | 1. Background a. Cesarean birth is the most common major surgical procedure performed in the United States, with rate of about 31.9% of deliveries.1 Pain management following cesarean birth involves a combination of opioid and non-opioid analgesia. Prescription opioid abuse and dependence has increased rapidly in the United States over the past two decades, with a four-fold increased rate of unintentional overdose using prescription opioids from 2000-2010.2 An evaluation by the Centers for Disease Control and Prevention found that patients can indeed become addicted to opioids following treatment of acute pain, including after Cesarean birth.3,4 b. A small number of obstetricians at UPH-Meriter currently attempt to decrease postpartum opioid use and pain by injecting bupivacaine into the cesarean incision site. This is not a universal practice. 2. Project Purpose/ Goals a. Purpose: The purpose of this project is to determine whether our patients who receive bupivacaine injections in their Cesarean incision have improved pain or less opioid use after Cesarean delivery. b. Goals: i. Determine whether bupivacaine injections into the Cesarean incision site decrease postpartum pain and postpartum opioid use ii. If bupivacaine injections are found to decrease postpartum pain or opioid use, this information would be used to potential inform universal adoption of this practice. c. Procedures: i. Proposed work flow: 1. This project will be a retrospective chart review of women undergoing Cesarean delivery at Meriter hospital. Whether or not women received bupivacaine injections at the cesarean incision site will be determined based upon manual chart review of the operative note. Outcome is the cumulative dose of morphine milligram equivalents (MME) and pain scores in the first 24 hours after Cesarean with additional outcome measures to include MME dose at 48, 72, and during hospital stay. a. A list of women who underwent Cesarean delivery from 10/01/2015 through 12/31/2019 has already been obtained for a separate project. b. Perform chart review via Epic to assess for whether bupivacaine was injected into Cesarean incision site c. Analyze the data to determine whether the cumulative dose of MME in the first 24 hours after Cesarean delivery is lower among women who receive bupivacaine d. Analyze the data to determine whether the postpartum pain scores in the first 24 hours after Cesarean delivery is lower among women who receive bupivacaine | 0 | Assist with data extraction from the electronic health record | We will teach you to review the electronic health record and enter data into REDCap | We can teach you. Skills will include use of Epic and REDCap | QI Exemption obtained in 2020 | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | UW undergraduates interested in research | No | Andrea Zorbas | No | Cesarean Incision Bupivacaine Injections: Do they reduce post-cesarean pain and opioid use? : 1. Background a. Cesarean birth is the most common major surgical procedure performed in the United States, with rate of about 31.9% of deliveries.1 Pain management following cesarean birth involves a combination of opioid and non-opioid analgesia. Prescription opioid abuse and dependence has increased rapidly in the United States over the past two decades, with a four-fold increased rate of unintentional overdose using prescription opioids from 2000-2010.2 An evaluation by the Centers for Disease Control and Prevention found that patients can indeed become addicted to opioids following treatment of acute pain, including after Cesarean birth.3,4 b. A small number of obstetricians at UPH-Meriter currently attempt to decrease postpartum opioid use and pain by injecting bupivacaine into the cesarean incision site. This is not a universal practice. 2. Project Purpose/ Goals a. Purpose: The purpose of this project is to determine whether our patients who receive bupivacaine injections in their Cesarean incision have improved pain or less opioid use after Cesarean delivery. b. Goals: i. Determine whether bupivacaine injections into the Cesarean incision site decrease postpartum pain and postpartum opioid use ii. If bupivacaine injections are found to decrease postpartum pain or opioid use, this information would be used to potential inform universal adoption of this practice. c. Procedures: i. Proposed work flow: 1. This project will be a retrospective chart review of women undergoing Cesarean delivery at Meriter hospital. Whether or not women received bupivacaine injections at the cesarean incision site will be determined based upon manual chart review of the operative note. Outcome is the cumulative dose of morphine milligram equivalents (MME) and pain scores in the first 24 hours after Cesarean with additional outcome measures to include MME dose at 48, 72, and during hospital stay. a. A list of women who underwent Cesarean delivery from 10/01/2015 through 12/31/2019 has already been obtained for a separate project. b. Perform chart review via Epic to assess for whether bupivacaine was injected into Cesarean incision site c. Analyze the data to determine whether the cumulative dose of MME in the first 24 hours after Cesarean delivery is lower among women who receive bupivacaine d. Analyze the data to determine whether the postpartum pain scores in the first 24 hours after Cesarean delivery is lower among women who receive bupivacaine ____________________________________________________________________________ Role - Assist with data extraction from the electronic health record; IRB Status - QI Exemption obtained in 2020; Skills - We can teach you. Skills will include use of Epic and REDCap | Kathleen Antony, kantony@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudeD5QDIL5aZ03NuuUbMteUfXGWk5aefVuHq20IOf9rHfb0rIAccQM63GWwnH5KAz0 | |||||||||
| 17/11/2021 | aufhauserd@surgery.wisc.edu | David | Aufhauser | MD | Assistant Professor | 2.022.559.435 | Surgery | Transplant Surgery | Impact of Visceral Adiposity on Pancreas Transplant Outcomes | Visceral adiposity is associated with increased risk of post-transplant diabetes in kidney and liver transplant. However, little is known about the impact of visceral adiposity on pancreas allograft survival. The effects of visceral adiposity and metabolic syndrome may be even more important in this setting, particularly in pancreas transplants performed for type II diabetics, because insulin resistance directly impacts graft performance. This project will involve a retrospective review of pre-operative CT scans of pancreas transplant recipients to quantitatively assess distribution of adipose tissue and muscle mass. These metrics will be linked with demographic information and outcomes data to assess how adipose distribution and sarcopenia impact pancreas transplant outcomes. The findings may impact selection criteria for pancreas transplant candidates, particularly those with type II diabetes. | 1 | The student will be the lead researcher on this project. They will review CT scans, analyze results, and write up the results. | Some familiarity with biostatistics is helpful. | Project will be submitted for inclusion in existing retrospective transplant outcomes IRB. | No | Yes | Yes | Shorter term projects | UW undergraduates interested in research | Aufhauser DD Jr, Hernandez P, Concors SJ, O’Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. HDAC2 targeting stabilizes the CoREST coplex in renal tubular cells and protects against renal ischemia/reperfusion injury. Scientific Reports. 2021 Apr 27. Krumeich L, Mancinelli J, Cucchiara A, Eddinger K, Aufhauser DD Jr, Goldberg D. Siegelman E, Rosen M, Reddy KR, Hoteit M, Furth E, Olthoff K, Shaked A, Levine MH, Abt PL. Occult Hepatocellular Carcinoma Associated with Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients. Liver Transplantation. 2021 Apr 14. Connor J, Aufhauser DD Jr, Welch B, Leverson G, Al-Adra D. Defining post-operative transfusion thresholds in liver transplant recipients. Transfusion. 2020 Dec 25. Aufhauser DD Jr, Peng AW, Murken DR, Concors SJ, Abt PL, Sawinski D, Bloom RD, Reese PP, Levine MH. Impact of Prolonged Dialysis Prior to Renal Transplantation. Clinical Transplantation. 2018 Jun 25. Roberts SE, Aufhauser DD Jr, Braslow BM. Large bowel obstruction leading to disseminated salmonellosis: A case report and review of the literature. ACS Case Reviews in Surgery. 2018 Apr. Murken DR, Peng A, Aufhauser DD Jr, Abt PL, Goldberg DS, Levine MH. Same Policy, Different Impact: Center-Level Effects of Share 35 Liver Allocation. Liver Transplantation. 2017 Apr 13. Aufhauser DD Jr, Sadot E, Murken DR, Eddinger K, Hoteit M, Abt PL, Goldberg DS, DeMatteo RP, Levine MH. Incidence of occult intrahepatic metastasis in hepatocellular carcinoma treated with transplantation corresponds to early recurrence rates after partial hepatectomy. Annals of Surgery. 2017 Jan 12. Aufhauser DD Jr, Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, Redfield RR, Abt PL, Wang L, Svoronos N, Thomasson A, Reese PP, Hancock WW, Levine MH. Improved Renal Ischemia Tolerance in Females Influences Kidney Transplantation Outcomes. Journal of Clinical Investigation. 2016 April 18. | No | N/A | No | Impact of Visceral Adiposity on Pancreas Transplant Outcomes: Visceral adiposity is associated with increased risk of post-transplant diabetes in kidney and liver transplant. However, little is known about the impact of visceral adiposity on pancreas allograft survival. The effects of visceral adiposity and metabolic syndrome may be even more important in this setting, particularly in pancreas transplants performed for type II diabetics, because insulin resistance directly impacts graft performance. This project will involve a retrospective review of pre-operative CT scans of pancreas transplant recipients to quantitatively assess distribution of adipose tissue and muscle mass. These metrics will be linked with demographic information and outcomes data to assess how adipose distribution and sarcopenia impact pancreas transplant outcomes. The findings may impact selection criteria for pancreas transplant candidates, particularly those with type II diabetes. ____________________________________________________________________________ Role - The student will be the lead researcher on this project. They will review CT scans, analyze results, and write up the results. ; IRB Status - Project will be submitted for inclusion in existing retrospective transplant outcomes IRB.; Skills - Some familiarity with biostatistics is helpful. | David Aufhauser, aufhauserd@surgery.wisc.edu -- Co-Mentor: | ||||||||||
| 15/12/2021 | babal@wisc.edu | Jessica | Babal | MD | Assistant Professor, Pediatrics | 4.402.123.794 | Pediatrics | Listen In! Storytelling in Healthcare | Support the Listen In! Storytelling Collaborative in generating procedural documents, educational materials, recruitment materials. Perform literature reviews, support data collection, support grant writing. Collaborate in discussions on storytelling ethics. Options to author manuscript on storytelling in healthcare, topics might include storytelling approaches, impact, or history. | 1 | Support the Listen In! Storytelling Collaborative in generating procedural documents, educational materials, recruitment materials. Perform literature reviews, support data collection, support grant writing. Collaborate in discussions on storytelling ethics. Options to author manuscript on storytelling in healthcare, topics might include storytelling approaches, impact, or history. | The student should be highly independent and self-motivated. However the student will receive an abundance of support and guidance from the mentor and mentor support teams throughout the summer. | Organization. Dependability. Good communication skills. Attention to detail. Good follow-up and follow-through. Interest in storytelling. Prior creative writing or storytelling experience only optional. | N/A | No | Yes | Yes | Shorter term projects, Research Electives for credit | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | Brad Kerr (bkerr@wisc.edu), Megan Moreno (moreno@wisc.edu) | Yes | Listen In! Storytelling in Healthcare: Support the Listen In! Storytelling Collaborative in generating procedural documents, educational materials, recruitment materials. Perform literature reviews, support data collection, support grant writing. Collaborate in discussions on storytelling ethics. Options to author manuscript on storytelling in healthcare, topics might include storytelling approaches, impact, or history. ____________________________________________________________________________ Role - Support the Listen In! Storytelling Collaborative in generating procedural documents, educational materials, recruitment materials. Perform literature reviews, support data collection, support grant writing. Collaborate in discussions on storytelling ethics. Options to author manuscript on storytelling in healthcare, topics might include storytelling approaches, impact, or history. ; IRB Status - N/A; Skills - Organization. Dependability. Good communication skills. Attention to detail. Good follow-up and follow-through. Interest in storytelling. Prior creative writing or storytelling experience only optional. | Jessica Babal, babal@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucjTJQZWrsgmHLJfJftGPForV2X5K5_JE_jc62G5bsjacibnVhHGja1K8VQTaOXL9c | ||||||||||
| 19/01/2022 | cbarreda@wisc.edu | Christina | Barreda | MD | Assistant Professor of Pediatrics | 6.307.287.376 | Pediatrics | Pulmonology and Sleep Medicine | Megan Moreno | moreno@wisc.edu | Pediatrics | General Pediatrics & Adolescent Medicine | Understanding the Experience and Perspectives of Caregivers of Pediatric Pulmonary Patients Around Social Media Use to Obtain Information About Their Child’s Health | Social media has become a prominent source of information that many caregivers of pediatric patients use to learn about their child’s health. This study aims to use qualitative focus groups to (1) Understand and describe how caregivers of pediatric pulmonary patients currently use social media to obtain medical information and the impact of that information on health care decisions they make for their child, and (2) Identify the preferred social media platforms and educational material caregivers of pediatric pulmonary patients would like to receive via social media from their child’s medical team. We expect the results of this study to inform the pediatric pulmonary team about ways that we can utilize social media to connect with caregivers of our patients and provide them with timely and accurate information that is relevant to decisions around their child’s health. | 1 | Development of codebook, identifying themes, assisting with coding and analyzing the qualitative data from focus groups of caregivers of pediatric pulmonary patients | moderate | Ability to do a literature review | Has not yet been submitted, however will be minimal risk submission | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Unsure / Depends | Megan Moreno moreno@wisc.edu; Michael Rock mjrock@wisc.edu | Unsure / Depends | Understanding the Experience and Perspectives of Caregivers of Pediatric Pulmonary Patients Around Social Media Use to Obtain Information About Their Child’s Health: Social media has become a prominent source of information that many caregivers of pediatric patients use to learn about their child’s health. This study aims to use qualitative focus groups to (1) Understand and describe how caregivers of pediatric pulmonary patients currently use social media to obtain medical information and the impact of that information on health care decisions they make for their child, and (2) Identify the preferred social media platforms and educational material caregivers of pediatric pulmonary patients would like to receive via social media from their child’s medical team. We expect the results of this study to inform the pediatric pulmonary team about ways that we can utilize social media to connect with caregivers of our patients and provide them with timely and accurate information that is relevant to decisions around their child’s health. ____________________________________________________________________________ Role - Development of codebook, identifying themes, assisting with coding and analyzing the qualitative data from focus groups of caregivers of pediatric pulmonary patients; IRB Status - Has not yet been submitted, however will be minimal risk submission; Skills - Ability to do a literature review | Christina Barreda, cbarreda@wisc.edu -- Co-Mentor: Megan Moreno moreno@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudeAu1JG8UHPYruEsC3ljwiFY2dIsIDngLMgFaqc-a2lWSUfDCC_cu0VPMUXzS8ItM | |||||
| 03/01/2022 | cb4@medicine.wisc.edu | Christie | Bartels | MD MS | Associate Professor, Division Chief | 608 | Rheumatology | Rheumatology | Lupus Care Continuum Research | Systemic Lupus Erythematous (SLE) affects 1.5 million Americans and is three times more common in people of minority race and ethnicity who face 7-fold risk of kidney failure and other outcome disparities. The goal of this project is to identify patient and context factors that predict such retention in care and on therapy for lupus, as well as how these steps impact damage-free survival among a database cohort of SLE patients. In other diseases such as HIV, patients retained in care and on therapy over time has been measured, correlated with disease outcomes, and used to targets improving care and health outcomes. The Bartels Lab is applying this framework to the care of SLE patients to understand and quantify health disparities gaps with the aim of developing interventions to reduce health disparities in lupus. Specifically, the role of the student researcher will be to complete medical record abstractions using REDCAP, conduct data quality audits, interpret findings, create figures, and write text for a scientific abstract and manuscript. The student will learn interpretation of statistical outputs, and if interested can be involved in statistical analysis. The student’s role can be tailored to fit interests and skills; all are encouraged to apply. The student will gain skills in literature searches, citation management, epidemiologic and health services research studies, health disparities, biostatistics, and rheumatic conditions and their management. | 1 | Data construction, data quality, and interpretation | Tailorable | NA | Approved | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Bartels CM, Rosenthal A, Wang X, Ahmad U, Chang I, Ezeh N, Garg S, Schletzbaum M, Kind A. Investigating Lupus Retention in Care to Inform Interventions for Disparities Reduction: An urban cohort study. Arthritis Research and Therapy. 2020; 22(1):35. Schletzbaum M, Chen Y, Sheehy A, Kaiksow F, Powell R, Gilmore-Bykovskyi A, Kind A, Bartels CM. Differences in 30-Day Rehospitalization Risk and Predictors by Age Group Among Patients with Lupus in Medicare. Target Journal: Arthritis Care and Research. Ezeh N* (Shapiro alum), McKown T, Garg S, Bartels CM. Smoking Exposure in Pack-Years Predicts Cutaneous Manifestations of Systemic Lupus Erythematosus. In Revision: Lupus. | Yes | Monica Messina Program Manager; Jason Weitzman Division Administrator | ||||||||||||
| 13/01/2022 | hbartlett2@wisc.edu | Heather | Bartlett | MD | Professor of Pediatrics and Medicine | 6.082.626.253 | Pediatrics | Cardiology | Medicine | Cardiovascular Medicine | Luke Lamers | llamers@pediatrics.wisc.edu | Pediatrics | Cardiology | Infective Endocarditis in Congenital Heart Disease - Cumulative Incidence and Predictors. | UW congenital cardiology providers have recently seen a significant increase in the incidence of endocarditis in pediatric and adult patients with congenital heart disease and also in pediatric patients without congenital heart disease. This incidence of disease is far in excess of what is published for the congenital heart disease and general pediatric population. The cause of this increased incidence is unknown and the purpose of the study is to review the institutional experience from 2010 to 2020 with endocarditis in all congenital heart disease patients and in pediatric patients without congenital heart disease diagnosed with endocarditis to identify clinical trends and potential causes. Medical records will be reviewed. We will obtain data from a combination of record requests from the enterprise analytics group and individual medic al records if necessary. The patient groups to be included in this study include any non-surgical pediatric patients admitted to between 5/2010-5/2020. The data that will be reviewed will include diagnosis of endocarditis, congenital heart disease, non-cardiac commodities, medic al history of surgery, dental procedure, and other treatments, current hospitalization treatment, lab results, as well as patient demographics. Continuous variables will be presented as mean ± standard deviation or median and range, depending on the distribution. Categorical variables will be summarized as frequencies and percentages. Univariate and multiple logistic regression models will be performed to examine the association between diagnosis of endocarditis and a series of predictors to identify potential risk factors for endocarditis. Two-tailed P-values <0.05 will be considered indicative of statistical significance. | 0 | Data acquisition, data analysis, writing & presenting work | Moderate. Three mentors, Drs. Zhang, Lamers and Bartlett will provide guidance but independent skills in reviewing the data and electronic medical records are needed. | Excel, word, powerpoint, develop skills in reviewing the electronic medical record | approved | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | xiao.zhang@wisc.edu | Yes | Infective Endocarditis in Congenital Heart Disease - Cumulative Incidence and Predictors.: UW congenital cardiology providers have recently seen a significant increase in the incidence of endocarditis in pediatric and adult patients with congenital heart disease and also in pediatric patients without congenital heart disease. This incidence of disease is far in excess of what is published for the congenital heart disease and general pediatric population. The cause of this increased incidence is unknown and the purpose of the study is to review the institutional experience from 2010 to 2020 with endocarditis in all congenital heart disease patients and in pediatric patients without congenital heart disease diagnosed with endocarditis to identify clinical trends and potential causes. Medical records will be reviewed. We will obtain data from a combination of record requests from the enterprise analytics group and individual medic al records if necessary. The patient groups to be included in this study include any non-surgical pediatric patients admitted to between 5/2010-5/2020. The data that will be reviewed will include diagnosis of endocarditis, congenital heart disease, non-cardiac commodities, medic al history of surgery, dental procedure, and other treatments, current hospitalization treatment, lab results, as well as patient demographics. Continuous variables will be presented as mean ± standard deviation or median and range, depending on the distribution. Categorical variables will be summarized as frequencies and percentages. Univariate and multiple logistic regression models will be performed to examine the association between diagnosis of endocarditis and a series of predictors to identify potential risk factors for endocarditis. Two-tailed P-values <0.05 will be considered indicative of statistical significance. ____________________________________________________________________________ Role - Data acquisition, data analysis, writing & presenting work; IRB Status - approved; Skills - Excel, word, powerpoint, develop skills in reviewing the electronic medical record | Heather Bartlett, hbartlett2@wisc.edu -- Co-Mentor: Luke Lamers llamers@pediatrics.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufDIOykPonUS7PoyrXk1h-LiSOffqRwlpH5AQS-RGtg2MCTeW1SAin9yjAS1DswcIs | |||
| 13/12/2021 | baschnagel@humonc.wisc.edu | Andrew | Baschnagel | M.D. | Associate Professor | 6.082.629.169 | Human Oncology | Radiomic and immune profiling of non-small cell lung cancer brain metastases. | This project will assess the radomic signatures of non-small cell lung cancer (NSCLC) brain metastases and associate them with transcriptomic signatures and immune profiles. The project will assess the correlation of immune infiltration of NSCLC brain metastases with radiomic metrics obtained from MRIs to determine if a prognostic signature exists. Immune infiltration of NSCLC brain metastases will be determined by RNAseq and IHC analysis of resected brain metastasis samples. Machine learning techniques will be performed to identify the features most predictive. A discovery and validation dataset will both be used. The student will get experience in oncological and radiologic principles of NSCLC and brain metastases. The student will learn about tumor immunology and will learn about MR imaging, radiomic profiling and RNAseq and IHC analysis. The student will learn basic statistical analysis. There is opportunity to be co-author on abstracts and publications. Previous students have been successful in publishing. https://www.humonc.wisc.edu/team_member/baschnagel/#research | 0 | The student will be responsible for updating the clinical database, contouring brain metastases and analyzing data. A majority of the time will be spent going through EMR to pull details about the patients treatment. | The student will meet weekly with Dr. Baschnagel but will need to work independent the rest of the time. Some remote work is possible. | excel, data organization, basic stats. Skill set in bioinformatics or computer programing welcomed but not needed. | Approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | N/A | No | Radiomic and immune profiling of non-small cell lung cancer brain metastases.: This project will assess the radomic signatures of non-small cell lung cancer (NSCLC) brain metastases and associate them with transcriptomic signatures and immune profiles. The project will assess the correlation of immune infiltration of NSCLC brain metastases with radiomic metrics obtained from MRIs to determine if a prognostic signature exists. Immune infiltration of NSCLC brain metastases will be determined by RNAseq and IHC analysis of resected brain metastasis samples. Machine learning techniques will be performed to identify the features most predictive. A discovery and validation dataset will both be used. The student will get experience in oncological and radiologic principles of NSCLC and brain metastases. The student will learn about tumor immunology and will learn about MR imaging, radiomic profiling and RNAseq and IHC analysis. The student will learn basic statistical analysis. There is opportunity to be co-author on abstracts and publications. Previous students have been successful in publishing. https://www.humonc.wisc.edu/team_member/baschnagel/#research ____________________________________________________________________________ Role - The student will be responsible for updating the clinical database, contouring brain metastases and analyzing data. A majority of the time will be spent going through EMR to pull details about the patients treatment.; IRB Status - Approved; Skills - excel, data organization, basic stats. Skill set in bioinformatics or computer programing welcomed but not needed. | Andrew Baschnagel, baschnagel@humonc.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudHDha8HTQe7u9bcgd5-pBqvZKaB-F71LxfE9tXF9CY2nhIPofeRMRHyXyXZqYvZTo | ||||||||||
| 07/01/2022 | gbhutani@medicine.wisc.edu | Gauri | Bhutani | MBBS | Clinical Assistant Professor | Medicine | Nephrology | Timothy Ziemlewicz, MD | TZiemlewicz@uwhealth.org | Radiology | A Novel Technique for Kidney Volume Assessment and Prognostication in ADPKD. | We will investigate 3D imaging as a novel and efficient modality for kidney volume measurement in patients with autosomal dominant polycystic kidney disease (ADPKD). Total kidney volume is currently the major prognostic marker for ADPKD and helps in deciding treatment program. Aim of this project is to investigate role of other novel renal radiology markers in prognostication in polycystic kidney disease. We will utilize retrospective cohort of ADPKD patients at UW and perhaps either from from CRISP cohort for external validation. | 1 | Work on kidney volume calculations of an ADPKD cohort by various methodologies - ellipsoid equation, and the semi-automated 3D imaging @ UW - along with our radiology co-investigators. 1. Finalize accuracy of kidney volume assessment by UW 3d imaging which is not yet being used at other centers. 2. Assess other novel radiology markers in PKD. Research will be submitted to national nephrology conference meeting (ASN renal week) and published as a manuscript (one or more based on findings). | None. Will train. | approved | philanthropic funds available | No (plan to use Dean's Office Funds) | Yes | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Genetic Counseling students, MPH students, UW undergraduates interested in research | No | Samantha Thompson (sjthomps@medicine.wisc.edu) | No | A Novel Technique for Kidney Volume Assessment and Prognostication in ADPKD.: We will investigate 3D imaging as a novel and efficient modality for kidney volume measurement in patients with autosomal dominant polycystic kidney disease (ADPKD). Total kidney volume is currently the major prognostic marker for ADPKD and helps in deciding treatment program. Aim of this project is to investigate role of other novel renal radiology markers in prognostication in polycystic kidney disease. We will utilize retrospective cohort of ADPKD patients at UW and perhaps either from from CRISP cohort for external validation. ____________________________________________________________________________ Role - Work on kidney volume calculations of an ADPKD cohort by various methodologies - ellipsoid equation, and the semi-automated 3D imaging @ UW - along with our radiology co-investigators. 1. Finalize accuracy of kidney volume assessment by UW 3d imaging which is not yet being used at other centers. 2. Assess other novel radiology markers in PKD. Research will be submitted to national nephrology conference meeting (ASN renal week) and published as a manuscript (one or more based on findings).; IRB Status - approved; Skills - None. Will train. | Gauri Bhutani, gbhutani@medicine.wisc.edu -- Co-Mentor: Timothy Ziemlewicz, MD TZiemlewicz@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueAshNPAs-Mikg1PXsGNfTJh2s1ptovySBt_mwl5Axvm1xqE2fwp9lqcPHaTbG4BT8 | ||||||||
| 06/02/2022 | fcaldera@medicine.wisc.edu | Freddy | Caldera | DO, MS | Associate Professor of Medicine | 6.086.288.201 | Medicine | Gastroenterology & Hepatology | Mary Hayney | mary.hayney@wisc.edu | Other | School of Pharmacy | Professor | Prospective, non-randomized study comprised of patients with IBD in the “HumoRal and CellULar initial and Sustained immunogenicity in patients with IBD” (HERCULES) cohort. We are continuing to evaluate vaccine induced immunity in patients with IBD. | 1 | data collection, excel, potentially writing, if has skills to work in the lab. We would have opportunities for the student to work in the lab. | excel, data collection | IRB approved | Yes | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Not currently available to mentor other students | No | fcaldera@medicine.wisc.edu | No | Professor: Prospective, non-randomized study comprised of patients with IBD in the “HumoRal and CellULar initial and Sustained immunogenicity in patients with IBD” (HERCULES) cohort. We are continuing to evaluate vaccine induced immunity in patients with IBD. ____________________________________________________________________________ Role - data collection, excel, potentially writing, if has skills to work in the lab. We would have opportunities for the student to work in the lab. ; IRB Status - IRB approved; Skills - excel, data collection | Freddy Caldera, fcaldera@medicine.wisc.edu -- Co-Mentor: Mary Hayney mary.hayney@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueAbig-xtI0ThrPZ1pRr77f8aVhA4n1XQdLmG-lSYobcqkU_JI38UZdS5sU2Z_o8M0 | ||||||
| 15/01/2022 | scho@uwhealth.org | Steve | Cho | MD | Professor of Radiology | 16.082.635.048 | Radiology | Nuclear Medicine and Molecular Imaging | Tyler Bradshaw, PhD | tbradshaw@uwhealth.org | Radiology | Imaging Sciences | Molecular PET Imaging Research | Multimodality molecular imaging with oncologic PET/CT and PET/MRI will play an important role in the development of precision medicine. In particular functional imaging with visual qualitative and quantitative PET tumor assessments promises to predict survival and accurate therapy response monitoring in cancer patients. We have several patient PET/CT databases with important clinical outcomes, which will require quantitative PET analyses of tumor burden and response using current and novel analysis methods and software tools. Advanced quantitative image analysis and artificial intelligence methods for automated image segmentation lesion identification are also being developed. Molecular imaging areas being explored include FDG PET for lymphoma and PSMA PET for prostate cancer. | 2 | A Shapiro summer student will be involved with the PET/CT and/or PET/MRI image curation using PET software analysis tools and retrospective imaging and clinical data collection working in conjunction with the mentor, co-mentor and other research trainees on the project. They will also be able to observe and have opportunity to be involved in current ongoing clinical and translational PET imaging and radiotheranostics research studies and participate in clinical conference to get an overview of this growing field of molecular imaging and theranostics. | Mentor, co-mentor and research post-doctoral fellow will instruct with initial and ongoing PET analyses, with independent student completion of analyses by the end of the summer. | Required: No prior PET or imaging research experience is required but only an interest in molecular imaging. Preferred: Interest in computer analyses, knowledge of Microsoft excel, computer software experience | Project is IRB approved | Yes | Radiology Department Support for 50% of summer student's stipend | Yes | Research Electives for credit | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research, Not currently available to mentor other students | No | Lorene Seman, lseman@uwhealth.org | No | Molecular PET Imaging Research: Multimodality molecular imaging with oncologic PET/CT and PET/MRI will play an important role in the development of precision medicine. In particular functional imaging with visual qualitative and quantitative PET tumor assessments promises to predict survival and accurate therapy response monitoring in cancer patients. We have several patient PET/CT databases with important clinical outcomes, which will require quantitative PET analyses of tumor burden and response using current and novel analysis methods and software tools. Advanced quantitative image analysis and artificial intelligence methods for automated image segmentation lesion identification are also being developed. Molecular imaging areas being explored include FDG PET for lymphoma and PSMA PET for prostate cancer. ____________________________________________________________________________ Role - A Shapiro summer student will be involved with the PET/CT and/or PET/MRI image curation using PET software analysis tools and retrospective imaging and clinical data collection working in conjunction with the mentor, co-mentor and other research trainees on the project. They will also be able to observe and have opportunity to be involved in current ongoing clinical and translational PET imaging and radiotheranostics research studies and participate in clinical conference to get an overview of this growing field of molecular imaging and theranostics.; IRB Status - Project is IRB approved; Skills - Required: No prior PET or imaging research experience is required but only an interest in molecular imaging. Preferred: Interest in computer analyses, knowledge of Microsoft excel, computer software experience | Steve Cho, scho@uwhealth.org -- Co-Mentor: Tyler Bradshaw, PhD tbradshaw@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudXgEjcXLL-bdoqVK2vraDss0boOK-5IEPwDaTlufNuqSN3U-FX_uH_D1OwBDqhJ0o | |||||
| 19/12/2021 | eric.cotter21@gmail.com | Eric | Cotter | MD | Orthopedic Surgery Resident | 9.203.629.221 | Orthopedics and Rehabilitation | Brian Grogan MD | grogan@ortho.wisc.edu | Orthopedics and Rehabilitation | Susceptibility of Cutibacterium Acnes to Blue Light Therapy Based on Subtype | Infection after shoulder surgery leads to significant morbidity to patients and puts significant strain on the healthcare system. The most common infectious organism following shoulder surgery is Cutibacterium acnes (C. acnes). The purpose of this study is to 1) determine if certain subtypes of C. acnes are more susceptible to blue light therapy (BLT), 2) determine the optimal BLT treatment regimen for C. acnes eradication, and 3) determine how long the antimicrobial properties of BLT persist. Study Design: In vitro study investigating various blue light protocols to try and optimize antimicrobial effects of blue light therapy. Phase 1: • Take the 60 C acnes specimens banked from recent investigation by Cotter et al.6 and subtype these samples. Phase 2: • Take 10 different C acnes subtypes, selected at random, and subject them to a series of different blue light therapy regimens. o Previous literature has reported the best antimicrobial effects of BLT with radiant exposures of 54-75 J/cm2. o The antimicrobial efficacy of serial administrations remains unknown. o In order to perform this study we need 2 things: The blue light dosing sensor created by Dr. Gold will be utilized to ensure dose delivered and the time it takes to deliver the dose. Prior to each treatment, a Thorslab power meter will be utilized to confirm that the sensor is appropriately calibrated having the two placed side by side at the same distance from the blue light therapy device. • Proposed Blue Light Therapy Regimens for each subtype of C acnes: o Single treatment 25J/cm2 o Single treatment 50J/cm2 o Single treatment 75J/cm2 o Single treatment 100J/cm2 o Serial treatment 25J/cm2 x2 treatments (total dose: 50J/cm2) o Serial treatment 25J/cm2 x3 treatments (total dose: 75J/cm2) o Serial treatment 25J/cm2 x4 treatments (total dose: 100J/cm2) o *each of these treatment regimens will have a corresponding control culture plate of each C acnes subtype that will be allowed to grow without inhibition. This will allow direct comparison of control or “no treatment” to the culture plate of a specific C acnes subtype that was treated with one of the above regimens. Phase 3: • Following treatments, we will maintain the cultures of C acnes for 2 weeks and see how long, if ever, it takes for C acnes colonies to regrow. o Quantitative culture analysis will be performed immediately following blue light treatment, at 7 days after blue light treatment, and at 14 days after blue light treatment. o The purpose of this study phase is to see how long blue light can sterilize for. We know that it is impossible to kill 100% of microbes with any treatment but the goal is to eradicate to an undetectable level that one would presume effectively lowers the likelihood of clinical manifestation of infection. This has clinical relevance if blue light can eradicate C acnes below a clinically detectable threshold for >1 week as patients could have a treatment in the office at their preop a week before or if they need serial treatments they could have one at their preop and one in the preop holding area. | 0 | Working in the lab to primarily perform the blue light treatments on the cultures, help the lab personnel with culture work, day to day manage the data spreadsheet of results and assist with manuscript preparation. | Attention to detail, reliable, on time. The culture work and how to do the blue light treatments are very easy to teach and do not require any background, | N/A - basic science | Orthopedic Department Funding | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | No | Myself, Brian Grogan are the main people. We will put the student in contact with the micro lab we work with once a student is selected and I have had a chance to meet and discuss the project with them. We have a formal project protocol completed that I can send to any students that are interested. | No | Susceptibility of Cutibacterium Acnes to Blue Light Therapy Based on Subtype: Infection after shoulder surgery leads to significant morbidity to patients and puts significant strain on the healthcare system. The most common infectious organism following shoulder surgery is Cutibacterium acnes (C. acnes). The purpose of this study is to 1) determine if certain subtypes of C. acnes are more susceptible to blue light therapy (BLT), 2) determine the optimal BLT treatment regimen for C. acnes eradication, and 3) determine how long the antimicrobial properties of BLT persist. Study Design: In vitro study investigating various blue light protocols to try and optimize antimicrobial effects of blue light therapy. Phase 1: • Take the 60 C acnes specimens banked from recent investigation by Cotter et al.6 and subtype these samples. Phase 2: • Take 10 different C acnes subtypes, selected at random, and subject them to a series of different blue light therapy regimens. o Previous literature has reported the best antimicrobial effects of BLT with radiant exposures of 54-75 J/cm2. o The antimicrobial efficacy of serial administrations remains unknown. o In order to perform this study we need 2 things: The blue light dosing sensor created by Dr. Gold will be utilized to ensure dose delivered and the time it takes to deliver the dose. Prior to each treatment, a Thorslab power meter will be utilized to confirm that the sensor is appropriately calibrated having the two placed side by side at the same distance from the blue light therapy device. • Proposed Blue Light Therapy Regimens for each subtype of C acnes: o Single treatment 25J/cm2 o Single treatment 50J/cm2 o Single treatment 75J/cm2 o Single treatment 100J/cm2 o Serial treatment 25J/cm2 x2 treatments (total dose: 50J/cm2) o Serial treatment 25J/cm2 x3 treatments (total dose: 75J/cm2) o Serial treatment 25J/cm2 x4 treatments (total dose: 100J/cm2) o *each of these treatment regimens will have a corresponding control culture plate of each C acnes subtype that will be allowed to grow without inhibition. This will allow direct comparison of control or “no treatment” to the culture plate of a specific C acnes subtype that was treated with one of the above regimens. Phase 3: • Following treatments, we will maintain the cultures of C acnes for 2 weeks and see how long, if ever, it takes for C acnes colonies to regrow. o Quantitative culture analysis will be performed immediately following blue light treatment, at 7 days after blue light treatment, and at 14 days after blue light treatment. o The purpose of this study phase is to see how long blue light can sterilize for. We know that it is impossible to kill 100% of microbes with any treatment but the goal is to eradicate to an undetectable level that one would presume effectively lowers the likelihood of clinical manifestation of infection. This has clinical relevance if blue light can eradicate C acnes below a clinically detectable threshold for >1 week as patients could have a treatment in the office at their preop a week before or if they need serial treatments they could have one at their preop and one in the preop holding area. ____________________________________________________________________________ Role - Working in the lab to primarily perform the blue light treatments on the cultures, help the lab personnel with culture work, day to day manage the data spreadsheet of results and assist with manuscript preparation.; IRB Status - N/A - basic science; Skills - Attention to detail, reliable, on time. The culture work and how to do the blue light treatments are very easy to teach and do not require any background, | Eric Cotter, eric.cotter21@gmail.com -- Co-Mentor: Brian Grogan MD grogan@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufgSIFvfjA0Y_wUN4Kc6OCCmK-5yBHOB20uftyrOnWNOp1iDTku630CpTo2rLGQqXI | ||||||||
| 09/01/2022 | dbd@medicine.wisc.edu | Dawn | Davis | MD, PhD | Professor | 9.202.221.568 | Medicine | Endocrinology | Reka Sundaram-Stukel - Research Fellow, Department of Economics, UW-Madison | rsundara@wisc.edu | Other | Economics | Health Economics of Chronic Disease in Wisconsin | Very little is written about how to classify the costs of illnesses. Typically, disease costs vary by classification, comorbidities, and progression—much of the literature on costing uses meta sources for classifying the per-patient cost of illnesses. We have acquired Wisconsin all-payer data on billed charges for chronic conditions like diabetes, hypertension, heart disease, obesity, Alzheimers-dementia, anxiety, depression, and other mental disorders. This data is aggregated at the county level for Wisconsin and also has data on charges for patients diagnosed with COVID-19. Because billed charges are inflated, we also have data at the county level on the cost to charge ratio, which will allow us to classify charges as mean payable amounts. The challenges with data like this are understanding how clinicians can leverage this information for their analysis and creating a comprehensive reference for it. The main project goal is to develop comprehensive referenceable peer-reviewed articles that describe the cost universe, utilization, and prevalence of disease clusters. To this end, we are looking for passionate researchers who want to write about the costs of chronic conditions before and during COVID-19 for four clusters of illnesses. The first group is diabetes, hypertension, and obesity; the second group is heart disease, hypertension, and obesity; the third group is Alzheimer's-dementia, and the fourth cluster is anxiety-depression and other mental health. The data is clean, and it has prevalence, costs by disease, payer, and use for seven age groups and 72 Wisconsin counties. This means we have seven observations per county, where each age group is a distinct aggregate representative agent creating 504 observations per year (2019 and 2020). There are three distinct form of additional analysis one can perform: 1. How did masking mandates in 2020 help prevent overloading the Wisconsin health system compared to the counterfactual of no masking? Cost effectiveness analysis of masking to the Wisconsin health system—what do we find? How might clinicians leverage this information, for public safety of at-risk patients with chronic conditions, as variants enter or if COVID-19 endemic during peak exposure periods? 2. How might cost and prevalence data on COVID-19 patients help clinicians prepare for long-covid-19? 3. Telemedicine became prominent during COVID-19 so inpatient clinic visits went down. Looking forward is telemedicine a cost-effective solution for routine non-invasive visits? Can we determine this from this data? It also has separated data for patients with COVID-19 for the year 2020. Finally, we hope to write rapid-fire academic articles for peer review to journals like Health Affairs, Annals of Internal Medicine, and Jama psychiatry or field-related journals. | 0 | The student will primarily work with Dr. Sundaram-Stekel on data analysis and development of novel questions as well as manuscript writing to provide clinical perspective. The student will also review data and writing with Dr. Davis to guide clinical insight for the project. | moderate | none required | n/a | this project has been partially funded by a grant from the CDC to the Wisconsin Dept of Health Services | No (plan to use Dean's Office Funds) | Yes | work with Dr. Sundaram-Stekel may be available for shorter term projects | MPH students, PhD students | No | n/a | Yes | Health Economics of Chronic Disease in Wisconsin: Very little is written about how to classify the costs of illnesses. Typically, disease costs vary by classification, comorbidities, and progression—much of the literature on costing uses meta sources for classifying the per-patient cost of illnesses. We have acquired Wisconsin all-payer data on billed charges for chronic conditions like diabetes, hypertension, heart disease, obesity, Alzheimers-dementia, anxiety, depression, and other mental disorders. This data is aggregated at the county level for Wisconsin and also has data on charges for patients diagnosed with COVID-19. Because billed charges are inflated, we also have data at the county level on the cost to charge ratio, which will allow us to classify charges as mean payable amounts. The challenges with data like this are understanding how clinicians can leverage this information for their analysis and creating a comprehensive reference for it. The main project goal is to develop comprehensive referenceable peer-reviewed articles that describe the cost universe, utilization, and prevalence of disease clusters. To this end, we are looking for passionate researchers who want to write about the costs of chronic conditions before and during COVID-19 for four clusters of illnesses. The first group is diabetes, hypertension, and obesity; the second group is heart disease, hypertension, and obesity; the third group is Alzheimer's-dementia, and the fourth cluster is anxiety-depression and other mental health. The data is clean, and it has prevalence, costs by disease, payer, and use for seven age groups and 72 Wisconsin counties. This means we have seven observations per county, where each age group is a distinct aggregate representative agent creating 504 observations per year (2019 and 2020). There are three distinct form of additional analysis one can perform: 1. How did masking mandates in 2020 help prevent overloading the Wisconsin health system compared to the counterfactual of no masking? Cost effectiveness analysis of masking to the Wisconsin health system—what do we find? How might clinicians leverage this information, for public safety of at-risk patients with chronic conditions, as variants enter or if COVID-19 endemic during peak exposure periods? 2. How might cost and prevalence data on COVID-19 patients help clinicians prepare for long-covid-19? 3. Telemedicine became prominent during COVID-19 so inpatient clinic visits went down. Looking forward is telemedicine a cost-effective solution for routine non-invasive visits? Can we determine this from this data? It also has separated data for patients with COVID-19 for the year 2020. Finally, we hope to write rapid-fire academic articles for peer review to journals like Health Affairs, Annals of Internal Medicine, and Jama psychiatry or field-related journals. ____________________________________________________________________________ Role - The student will primarily work with Dr. Sundaram-Stekel on data analysis and development of novel questions as well as manuscript writing to provide clinical perspective. The student will also review data and writing with Dr. Davis to guide clinical insight for the project.; IRB Status - n/a; Skills - none required | Dawn Davis, dbd@medicine.wisc.edu -- Co-Mentor: Reka Sundaram-Stukel - Research Fellow, Department of Economics, UW-Madison rsundara@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud7RJGN6f-gnAJhQIqzS_U-7paWcna142kXOptJFjB1YoeFT4JwBmhPnVG0nnT_gJc | |||||
| 07/12/2021 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Chair | 6.082.655.967 | Neurological Surgery | Uma Wesley PhD | wesley@neurosurgery.wisc.edu | Neurological Surgery | Shapiro Summer Research Program - 2022 | The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. | 0 | Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. | Fairly independent | Some exposure to basic lab technique. However, we will train. | approved | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | see lab webpage | Yes | wesley@neurosurgery.wisc.edu | Yes | Shapiro Summer Research Program - 2022: The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. ____________________________________________________________________________ Role - Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field.; IRB Status - approved; Skills - Some exposure to basic lab technique. However, we will train. | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Uma Wesley PhD wesley@neurosurgery.wisc.edu | |||||||
| 23/12/2021 | dempsey@neurosurgery.wisc.edu | Robert | Dempsey | MD | Professor and Manucher J. Javid Chair | 608 | Neurological Surgery | Carol Mitchell, PhD | ccm@medicine.wisc.edu | Medicine | Cardiovascular Medicine | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation | Stroke Prevention in the Native American Population - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes than compared to US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. | 0 | MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations. | Curious / multitasking / willing to learn new skills / teamwork | Approved 2019-1550 | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Yes | Stephanie Wilbrand, PhD - research administrator - wilbrand@neurosurgery.wissc.edu | Yes | Stroke Prevention in the Native American Population (Clinical research) - the Oneida Nation: Stroke Prevention in the Native American Population - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes than compared to US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will conduct clinical research activities related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. ____________________________________________________________________________ Role - MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the health history and stroke risk quiz results with a project team member. The MD student will also perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how clinical risk factors present in Native Americans compared to other populations. ; IRB Status - Approved 2019-1550; Skills - Curious / multitasking / willing to learn new skills / teamwork | Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Carol Mitchell, PhD ccm@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueiQ2lZIeUf-Xkp-B0rZN-R4UCkgMco6LNMqruIZ5zszfabXDAZC-14NZYgOyzLHJM | |||||||
| 14/01/2022 | dey@neurosurgery.wisc.edu | Mahua | Dey | MD | Assistant Professor of Neurosurgery | 2.814.136.174 | Neurological Surgery | Impact of gender and race on academic collaboration and publications | One of the marker of academic success and productivity is publications and collaborations. We are interested in understanding the effect of gender and race on scientific collaborations and publications of academic faculty by their academic grade in Neuro-Oncology. For the project we will analyze the PubMed publication list of Neuro-oncologists to obtain publication data. | 0 | Primary data collection, data analysis and writing up results | High | Literature search | NA | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | PhD students | Unsure / Depends | N/A | No | Impact of gender and race on academic collaboration and publications : One of the marker of academic success and productivity is publications and collaborations. We are interested in understanding the effect of gender and race on scientific collaborations and publications of academic faculty by their academic grade in Neuro-Oncology. For the project we will analyze the PubMed publication list of Neuro-oncologists to obtain publication data. ____________________________________________________________________________ Role - Primary data collection, data analysis and writing up results; IRB Status - NA; Skills - Literature search | Mahua Dey, dey@neurosurgery.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucWbWIfRH2ZcNR2bxhYuva6Qa7QCsIDLp7BjxpvebJ32G8UOnmneRMoJ2oCKyA2lsk | ||||||||||
| 07/12/2021 | huy.dinh@wisc.edu | Huy | Dinh | Ph.D. | Assistant Professor | 6.082.632.890 | Oncology | Biostatistics and Medical Informatics | Bioinformatics analysis of cancer immunology data | Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early cancer detection and immunotherapy response and potential targets for cancer treatment. Thus, we will train prospective students to perform statistical and computational analyses to address biological questions in cancer immunology. They will work with graduate students and postdocs on current projects in the lab studying immunology in multiple cancer types. Their analysis will be acknowledged by authorship in the lab's manuscripts. Website: dinhlab.oncology.wisc.edu | 0 | Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project. | N/A | Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | N/A | No | No (plan to use Dean's Office Funds) | N/A | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Unsure / Depends | N/A | Unsure / Depends | Bioinformatics analysis of cancer immunology data: Our lab is interested in diverse computational analyses to identify immune cells as biomarkers for early cancer detection and immunotherapy response and potential targets for cancer treatment. Thus, we will train prospective students to perform statistical and computational analyses to address biological questions in cancer immunology. They will work with graduate students and postdocs on current projects in the lab studying immunology in multiple cancer types. Their analysis will be acknowledged by authorship in the lab's manuscripts. Website: dinhlab.oncology.wisc.edu ____________________________________________________________________________ Role - Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project.; IRB Status - N/A; Skills - Must be interested in curiosity-driven research and learning programming, and bioinformatics analysis. | Huy Dinh, huy.dinh@wisc.edu -- Co-Mentor: | |||||||||
| 07/02/2022 | dollerschell@wisc.edu | John | Dollerschell | Physician | Assistant Professor | 9.139.091.759 | Anesthesiology | Cardiac Anesthesiology | Critical Care | Goal Directed Resuscitation using Continuous Data in the Cardiac Surgical Patient | The purpose of this study is to assess if a shift in physician practice has occurred due to the presence of continuous hemodynamic data towards earlier intervention when compared to noncontiguous data. The hypothesis is that the change in practice will be manifested in improved STS outcome metrics. The split, and thus the two intervals being compared, will be denoted by the start of the HemoSphere trial by Edwards Lifescience. | 1 | Data Mining, Writing | Basic understanding of statistics | Pending IRB approval | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | No | John Dollerschell dollerschell@wisc.edu | No | Goal Directed Resuscitation using Continuous Data in the Cardiac Surgical Patient: The purpose of this study is to assess if a shift in physician practice has occurred due to the presence of continuous hemodynamic data towards earlier intervention when compared to noncontiguous data. The hypothesis is that the change in practice will be manifested in improved STS outcome metrics. The split, and thus the two intervals being compared, will be denoted by the start of the HemoSphere trial by Edwards Lifescience. ____________________________________________________________________________ Role - Data Mining, Writing; IRB Status - Pending IRB approval; Skills - Basic understanding of statistics | John Dollerschell, dollerschell@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuflqzAQWJEq766J6iQgEyBsvvaHQL309jdPmnsSwYJWY9G03XCS_dly_CfC1CZf6ag | |||||||||
| 14/01/2022 | melezaby@uwhealth.org | Mai | Elezaby | MD | Associate Professor | 608 | Radiology | Breast Imaging and Intervention section | PACS Integrated Feedback System for Independent Screening Mammography Interpretation by Trainees (Residents and Fellows) | Background and Significance: Learning how to interpret and dictate screening mammograms is an essential component of the breast imaging training during radiology residency and dedicated breast imaging fellowships offered across the nation. Historically, the most common teaching model in radiology has been the one-on-one view box teaching, where the teaching methodology is predominantly teacher-centered with occasional probing questions and discussions. One of the shortcomings of this technique is that it does not comprehensively assess the learner’s knowledge or ability to independently evaluate the images, assimilate findings into a reasonable diagnosis, formulate an appropriate management plan and subsequently dictate a coherent report with appropriate management recommendation to the referring clinician. In addition, it does not take into consideration the changes introduced into radiology workflow with the widespread adoption of digital imaging and Picture Archiving and Communication Systems (PACS). The introduction of PACS has allowed the decentralization of radiology departments. Faculty and trainees alike are able to rotate to various clinical sites and perform remote reading of exams from a single reading list. This technologic advent as well as the pressures of clinical volumes has led to a shift in radiology training. Trainees are more often independently reviewing exams and dictating preliminary reports, which are subsequently reviewed by faculty for editing and approval with less time for one-on-one teaching. This shift improves workflow efficiency and may be more suited to the new generation of learners, however does not necessarily close the loop with providing final feedback to trainees. The role of feedback has always been well recognized as an essential component of instructive learning in the educational literature. However, in radiology education research, the focus has mostly been on analysis of how radiologists search for and detect imaging abnormalities [9-14] with very little research focused on patterns of feedback provided to residents and its effect [15]. Subsequently, our clinical teaching of providing structured day-to-day feedback has great potential for deficiency. A recent survey of the American Alliance of Academic Chief Residents in Radiology reported that only 30% of programs have a mechanism in place to provide residents with feedback on report corrections. This highlighted an opportunity for us to explore. We utilized the availability and ease of a PACS integrated review system to provide a structured framework for delivering discrepancies in interpretation or changes in reports, yet with a chance to individually discuss complex cases. In a prior retrospective review of non-consecutive institutional data we analyzed patterns of discordance between initial-trainee, compared to final faculty interpretations according to the ACR BI-RADS finding types and impact of comparisons. This was a voluntary data submission through a generic resident review system that was not dedicated to mammography interpretation. This preliminary assessment identified that trainee interpretations were most commonly discordant for BI-RADS asymmetries not initially assessed as positive, and for mammograms initially assessed as positive but resolved with prior comparisons. In this current study we collected all discrepancies between initial-trainee and final-faculty-approved reports through a mammography-specific PACS integrated review system. The data collected includes 24 months of data which should accurately identify significant learning trends and highlighting areas of deficiencies which can guide future education initiatives. Hypothesis/Research Question: Providing an objective, consistent method of assessment of interpretive skills and reporting of screening mammograms by trainees (mammography-specific interface), allows collection of concrete data on common misses or inaccuracies that are encountered by trainees during independent screening mammography interpretation. Testing a mammography specific and accessible (PACS-integrated) comprehensive feedback mechanism in routine clinical practice (not a simulation test set), fulfills the tenants of good feedback practice. If proven to be successful and readily accepted by faculty and trainees, will be applied routinely in our practice outside of the study setting and can be adopted across different residency programs Prospectively collected data that accurately identifying significant learning trends and highlighting areas of deficiencies which can guide future education initiatives. Research Design and Methods: Aims: 1. To identify the factors contributing to discordance between initial-trainee compared to final faculty interpretations of screening mammograms in a routine clinical practice setting 2. To determine the significance of discordance between initial-trainee compared to final faculty interpretations of screening mammograms as compared to final mammogram outcomes Method: This is a retrospective review of prospectively collected report discrepancy data that is captured in an electronic database. We will analyze the types and significance of discordance between initial resident interpretation and final faculty interpretation, and correlate with patient (breast tissue density, presence of comparisons etc.. ) and trainee variables (level of residency, number of breast rotations, volumes of exams interpreted etc..). Innovation: Currently, there are no available objective and consistent assessment tools for residents’ performance in screening mammography education field. To date, this assessment has largely been a subjective measure. The tool we are proposing will adopt efficient workflow strategies while maintaining the educational mission of an academic practice. References: A. Monticciolo DL, Rebner M, Appleton CM, Newell MS, Farria DM, Sickles EA, Umphrey HR, Butler PF: The ACR/Society of Breast Imaging resident and fellowship training curriculum for breast imaging, updated. Journal of the American College of Radiology 2013, 10(3):207-210. e204. B. Roberts DH, Newman LR, Schwartzstein RM: Twelve tips for facilitating Millennials' learning. Medical teacher 2012, 34(4):274-278. C. Slanetz PJ, Kung J, Eisenberg RL: Teaching radiology in the millennial era. Academic radiology 2013, 20(3):387-389. D. Grimm LJ, Kuzmiak CM, Ghate SV, Yoon SC, Mazurowski MA: Radiology Resident Mammography Training: Interpretation Difficulty and Error-making Patterns. Academic radiology 2014, 21(7):888-892. E. Bailey JH, Roth TD, Kohli MD, Heitkamp DE: Real View Radiology—Impact on Search Patterns and Confidence in Radiology Education. Academic radiology 2014, 21(7):859-868. F. Shetty A, Hammer M, Gould J, Evens R: Results of the 2014 Survey of the American Alliance of Academic Chief Residents in Radiology. Academic radiology 2014, 21(10):1331-1347. G. D'Orsi CJ SE, Mendelson EB, Morris EA et al.: ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System. Reston, VA, American College of Radiology; 2013; 2013. H. Cook AJ, Elmore JG, Zhu W, Jackson SL, Carney PA, Flowers C, Onega T, Geller B, Rosenberg RD, Miglioretti DL: Mammographic Interpretation: Radiologists’ Ability to Accurately Estimate Their Performance and Compare It With That of Their Peers. Am J Roentgenol 2012, 199(3):695-702. I. Accreditation Council for Graduate Medical Education; Diagnostic Radiology. http://www.acgme.org/Portals/0/PFAssets/ProgramRequirements/420_diagnostic_radiology_2017-07-01.pdf?ver=2017-04-27-140316-620. Accessed December 4, 2017 J. Natesan R, Yang WT, Tannir H, Parikh J. Strategic Expansion Models in Academic Radiology. J Am Coll Radiol. 2016;13(3):329-334. | 1 | The student will review and tabulate the currently collected data with occasional Healthlink chart review and PACS review to confirm breast tissue density, presence of comparisons and clinical outcomes. The student will spend an initial week of orientation on the breast imaging service to become familiar with the performance and interpretation of screening mammography and workflows related to independent versus supervised interpretation methods. Completing data tabulation will then take 4 weeks, with remaining time (2-4 weeks) for statistical analysis and abstract /manuscript preparation. Statistical analysis support is provided by the department of biostatistics after request submission as part of interdepartmental agreement. | Will have one-on-one mentoring by Dr. Elezaby during the first week of orientation to the project and databases. Will then have weekly meetings with Dr. Elezaby to discuss the progress of the data collection, data analysis and abstract preparation for the remaining of the project period. | Proficiency in the use of Excel for data entry. Statistical analysis knowledge is helpful but not essential | The department of Radiology has an approved retrospective IRB review (Outcomes Research Protocol (2016-0418)). There is an internal department of radiology approval process Outcomes Research Request Form) that will be submitted and will cover the process of feedback report review. The student will complete HIPAA and Citi training provided through the UWSMPH. | No | No (plan to use Dean's Office Funds) | Yes | None | Not currently available to mentor other students | Yes | Phil Danzer (pdanzer@uwhealth.org) | Unsure / Depends | PACS Integrated Feedback System for Independent Screening Mammography Interpretation by Trainees (Residents and Fellows): Background and Significance: Learning how to interpret and dictate screening mammograms is an essential component of the breast imaging training during radiology residency and dedicated breast imaging fellowships offered across the nation. Historically, the most common teaching model in radiology has been the one-on-one view box teaching, where the teaching methodology is predominantly teacher-centered with occasional probing questions and discussions. One of the shortcomings of this technique is that it does not comprehensively assess the learner’s knowledge or ability to independently evaluate the images, assimilate findings into a reasonable diagnosis, formulate an appropriate management plan and subsequently dictate a coherent report with appropriate management recommendation to the referring clinician. In addition, it does not take into consideration the changes introduced into radiology workflow with the widespread adoption of digital imaging and Picture Archiving and Communication Systems (PACS). The introduction of PACS has allowed the decentralization of radiology departments. Faculty and trainees alike are able to rotate to various clinical sites and perform remote reading of exams from a single reading list. This technologic advent as well as the pressures of clinical volumes has led to a shift in radiology training. Trainees are more often independently reviewing exams and dictating preliminary reports, which are subsequently reviewed by faculty for editing and approval with less time for one-on-one teaching. This shift improves workflow efficiency and may be more suited to the new generation of learners, however does not necessarily close the loop with providing final feedback to trainees. The role of feedback has always been well recognized as an essential component of instructive learning in the educational literature. However, in radiology education research, the focus has mostly been on analysis of how radiologists search for and detect imaging abnormalities [9-14] with very little research focused on patterns of feedback provided to residents and its effect [15]. Subsequently, our clinical teaching of providing structured day-to-day feedback has great potential for deficiency. A recent survey of the American Alliance of Academic Chief Residents in Radiology reported that only 30% of programs have a mechanism in place to provide residents with feedback on report corrections. This highlighted an opportunity for us to explore. We utilized the availability and ease of a PACS integrated review system to provide a structured framework for delivering discrepancies in interpretation or changes in reports, yet with a chance to individually discuss complex cases. In a prior retrospective review of non-consecutive institutional data we analyzed patterns of discordance between initial-trainee, compared to final faculty interpretations according to the ACR BI-RADS finding types and impact of comparisons. This was a voluntary data submission through a generic resident review system that was not dedicated to mammography interpretation. This preliminary assessment identified that trainee interpretations were most commonly discordant for BI-RADS asymmetries not initially assessed as positive, and for mammograms initially assessed as positive but resolved with prior comparisons. In this current study we collected all discrepancies between initial-trainee and final-faculty-approved reports through a mammography-specific PACS integrated review system. The data collected includes 24 months of data which should accurately identify significant learning trends and highlighting areas of deficiencies which can guide future education initiatives. Hypothesis/Research Question: Providing an objective, consistent method of assessment of interpretive skills and reporting of screening mammograms by trainees (mammography-specific interface), allows collection of concrete data on common misses or inaccuracies that are encountered by trainees during independent screening mammography interpretation. Testing a mammography specific and accessible (PACS-integrated) comprehensive feedback mechanism in routine clinical practice (not a simulation test set), fulfills the tenants of good feedback practice. If proven to be successful and readily accepted by faculty and trainees, will be applied routinely in our practice outside of the study setting and can be adopted across different residency programs Prospectively collected data that accurately identifying significant learning trends and highlighting areas of deficiencies which can guide future education initiatives. Research Design and Methods: Aims: 1. To identify the factors contributing to discordance between initial-trainee compared to final faculty interpretations of screening mammograms in a routine clinical practice setting 2. To determine the significance of discordance between initial-trainee compared to final faculty interpretations of screening mammograms as compared to final mammogram outcomes Method: This is a retrospective review of prospectively collected report discrepancy data that is captured in an electronic database. We will analyze the types and significance of discordance between initial resident interpretation and final faculty interpretation, and correlate with patient (breast tissue density, presence of comparisons etc.. ) and trainee variables (level of residency, number of breast rotations, volumes of exams interpreted etc..). Innovation: Currently, there are no available objective and consistent assessment tools for residents’ performance in screening mammography education field. To date, this assessment has largely been a subjective measure. The tool we are proposing will adopt efficient workflow strategies while maintaining the educational mission of an academic practice. References: A. Monticciolo DL, Rebner M, Appleton CM, Newell MS, Farria DM, Sickles EA, Umphrey HR, Butler PF: The ACR/Society of Breast Imaging resident and fellowship training curriculum for breast imaging, updated. Journal of the American College of Radiology 2013, 10(3):207-210. e204. B. Roberts DH, Newman LR, Schwartzstein RM: Twelve tips for facilitating Millennials' learning. Medical teacher 2012, 34(4):274-278. C. Slanetz PJ, Kung J, Eisenberg RL: Teaching radiology in the millennial era. Academic radiology 2013, 20(3):387-389. D. Grimm LJ, Kuzmiak CM, Ghate SV, Yoon SC, Mazurowski MA: Radiology Resident Mammography Training: Interpretation Difficulty and Error-making Patterns. Academic radiology 2014, 21(7):888-892. E. Bailey JH, Roth TD, Kohli MD, Heitkamp DE: Real View Radiology—Impact on Search Patterns and Confidence in Radiology Education. Academic radiology 2014, 21(7):859-868. F. Shetty A, Hammer M, Gould J, Evens R: Results of the 2014 Survey of the American Alliance of Academic Chief Residents in Radiology. Academic radiology 2014, 21(10):1331-1347. G. D'Orsi CJ SE, Mendelson EB, Morris EA et al.: ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System. Reston, VA, American College of Radiology; 2013; 2013. H. Cook AJ, Elmore JG, Zhu W, Jackson SL, Carney PA, Flowers C, Onega T, Geller B, Rosenberg RD, Miglioretti DL: Mammographic Interpretation: Radiologists’ Ability to Accurately Estimate Their Performance and Compare It With That of Their Peers. Am J Roentgenol 2012, 199(3):695-702. I. Accreditation Council for Graduate Medical Education; Diagnostic Radiology. http://www.acgme.org/Portals/0/PFAssets/ProgramRequirements/420_diagnostic_radiology_2017-07-01.pdf?ver=2017-04-27-140316-620. Accessed December 4, 2017 J. Natesan R, Yang WT, Tannir H, Parikh J. Strategic Expansion Models in Academic Radiology. J Am Coll Radiol. 2016;13(3):329-334. ____________________________________________________________________________ Role - The student will review and tabulate the currently collected data with occasional Healthlink chart review and PACS review to confirm breast tissue density, presence of comparisons and clinical outcomes. The student will spend an initial week of orientation on the breast imaging service to become familiar with the performance and interpretation of screening mammography and workflows related to independent versus supervised interpretation methods. Completing data tabulation will then take 4 weeks, with remaining time (2-4 weeks) for statistical analysis and abstract /manuscript preparation. Statistical analysis support is provided by the department of biostatistics after request submission as part of interdepartmental agreement. ; IRB Status - The department of Radiology has an approved retrospective IRB review (Outcomes Research Protocol (2016-0418)). There is an internal department of radiology approval process Outcomes Research Request Form) that will be submitted and will cover the process of feedback report review. The student will complete HIPAA and Citi training provided through the UWSMPH.; Skills - Proficiency in the use of Excel for data entry. Statistical analysis knowledge is helpful but not essential | Mai Elezaby, melezaby@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucDYkOZ2p3uB-7JQTx0peVdhUBm0KBr5Vs6PNVOOElq32vKsoXpehvQ3b_XBqmHhyw | |||||||||
| 13/12/2021 | hfaust@medicine.wisc.edu | Hilary | Faust | MD, MS | Assistant Professor | 4.432.544.686 | Medicine | Pulmonary and Critical Care | Identifying Molecular Risk Factors for ARDS in Sepsis Patients | Critically ill sepsis patients commonly develop acute respiratory distress syndrome, a devastating syndrome of severe hypoxia with mortality approaching 50%. My goal is to identify biomarkers that identify whether patients are at risk of developing ARDS and if they may respond to targeted treatments. My focus is on damage-associated molecular patterns (DAMPs), including cell-free nuclear and mitochondrial DNA. These DAMPs can cause endothelial activation and dysfunction through various mechanisms including clot formation and signaling through receptors such as toll-like receptor-9 (TLR9). I have started an observational cohort of sepsis patients in the UW medical ICU. This cohort will be followed to determine which patients develop ARDS and to obtain plasma for use in a microfluidic model of lung endothelial function. Patient plasma will be incubated in the lung endothelial micro lumens with DNAse to degrade DNA and a TLR9 antagonist. Markers of endothelial dysfunction, live-dead stains, and assays for barrier function will be performed. Student responsibilities would include data extraction, patient screening and enrollment, sample pick up from the clinical lab, and could include sample processing and measurement of plasma markers such as cell-free DNA and cytokines depending on student interest. | 2 | Data coordinator: screen EMR, identify eligible patients, obtain consent, pick up clinical lab samples, populate clinical data into database, lab projects are also available (PCR, ELISA) | moderate | Screening EMR, data extraction, could include laboratory projects if interested | Approved | ICTR KL2 | No (plan to use Dean's Office Funds) | Yes | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | UW undergraduates interested in research | No | Jae Werndli jewerndli@medicine.wisc.edu | Unsure / Depends | Identifying Molecular Risk Factors for ARDS in Sepsis Patients: Critically ill sepsis patients commonly develop acute respiratory distress syndrome, a devastating syndrome of severe hypoxia with mortality approaching 50%. My goal is to identify biomarkers that identify whether patients are at risk of developing ARDS and if they may respond to targeted treatments. My focus is on damage-associated molecular patterns (DAMPs), including cell-free nuclear and mitochondrial DNA. These DAMPs can cause endothelial activation and dysfunction through various mechanisms including clot formation and signaling through receptors such as toll-like receptor-9 (TLR9). I have started an observational cohort of sepsis patients in the UW medical ICU. This cohort will be followed to determine which patients develop ARDS and to obtain plasma for use in a microfluidic model of lung endothelial function. Patient plasma will be incubated in the lung endothelial micro lumens with DNAse to degrade DNA and a TLR9 antagonist. Markers of endothelial dysfunction, live-dead stains, and assays for barrier function will be performed. Student responsibilities would include data extraction, patient screening and enrollment, sample pick up from the clinical lab, and could include sample processing and measurement of plasma markers such as cell-free DNA and cytokines depending on student interest. ____________________________________________________________________________ Role - Data coordinator: screen EMR, identify eligible patients, obtain consent, pick up clinical lab samples, populate clinical data into database, lab projects are also available (PCR, ELISA); IRB Status - Approved; Skills - Screening EMR, data extraction, could include laboratory projects if interested | Hilary Faust, hfaust@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf3c96RecShRJhRjJn8jZ4uipw2nHNDv8KOruYcpbhYqpreGas6064qpr2IMmg0IJc | |||||||||
| 19/01/2022 | mbfitzpatric@wisc.edu | Megan | Fitzpatrick | MD | Assistant Professor of Pathology | 6.082.625.922 | Pathology and Laboratory Medicine | HPV epidemiology and sequencing in Zimbabwe and Wisconsin | We have projects in Wisconsin and Zimbabwe exploring HPV genotype distribution in the adult population, and evaluating HPV breakthrough infections among HPV vaccinated girls (and adults in WI). The student would be involved in laboratory testing of the samples, data management, and project organization. Additional projects that the student could be involved with include: 1. RNAseq studies of HPV positive and negative squamous cell carcinoma, 2. Development of a probiotic vaginal ring for treatment of HPV, 3. Development and testing of a vaginal device to simulate bacterial vaginosis in a murine papillomavirus model. | 0 | Laboratory work and data management | With mentorship (should have some lab experience) | molecular methods are ideal (PCR, NGS) | Approved | No | Department has agreed to help cover these costs | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, UW undergraduates interested in research | No | N/A | Yes | HPV epidemiology and sequencing in Zimbabwe and Wisconsin: We have projects in Wisconsin and Zimbabwe exploring HPV genotype distribution in the adult population, and evaluating HPV breakthrough infections among HPV vaccinated girls (and adults in WI). The student would be involved in laboratory testing of the samples, data management, and project organization. Additional projects that the student could be involved with include: 1. RNAseq studies of HPV positive and negative squamous cell carcinoma, 2. Development of a probiotic vaginal ring for treatment of HPV, 3. Development and testing of a vaginal device to simulate bacterial vaginosis in a murine papillomavirus model. ____________________________________________________________________________ Role - Laboratory work and data management; IRB Status - Approved; Skills - molecular methods are ideal (PCR, NGS) | Megan Fitzpatrick, mbfitzpatric@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueGQt1yNPSTmrHsQdl8xx-So3lXLGRe81t6ZYtzLrJK4xhZvjiR-Z3Ypaf_g2JhDwo | ||||||||||
| 07/01/2022 | jfloberg@humonc.wisc.edu | John | Floberg | MD, PhD | Assistant Professor (CHS) | 608 | Human Oncology | Advanced imaging markers in prostate cancer | In the last several years there has been a dramatic increase in the use of advanced imaging modalities, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI), in the initial evaluation and staging of prostate cancer. These imaging modalities allow us to identify areas of cancer with far more accuracy and are changing the way we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative metrics can be derived from these images. However, the prognostic and biologic significance of these metrics has been little investigated. The overall aim of this project is to investigate the prognostic significance of PET imaging metrics, and the cancer biology associated with these metrics, in men with advanced prostate cancer treated with radiation therapy. | 1 | Review patient charts. Curate and contribute to a clinical database. Analyze clinical images (e.g. PET and MRI). Perform statistical analyses | The student should show initiative in asking specific questions within the context of the project outlined above. They should plan to independently analyze clinical or imaging data with regular check-ins and guidance (e.g. once weekly meetings) | Background with image analysis and/or coding would be helpful, but is not required | Approved, IRB exempt. | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students, UW undergraduates interested in research | No | Liz Forget (forget@humonc.wisc.edu) Belinda Buehl (bkbuehl@humonc.wisc.edu) | Unsure / Depends | Advanced imaging markers in prostate cancer: In the last several years there has been a dramatic increase in the use of advanced imaging modalities, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI), in the initial evaluation and staging of prostate cancer. These imaging modalities allow us to identify areas of cancer with far more accuracy and are changing the way we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative metrics can be derived from these images. However, the prognostic and biologic significance of these metrics has been little investigated. The overall aim of this project is to investigate the prognostic significance of PET imaging metrics, and the cancer biology associated with these metrics, in men with advanced prostate cancer treated with radiation therapy. ____________________________________________________________________________ Role - Review patient charts. Curate and contribute to a clinical database. Analyze clinical images (e.g. PET and MRI). Perform statistical analyses; IRB Status - Approved, IRB exempt. ; Skills - Background with image analysis and/or coding would be helpful, but is not required | John Floberg, jfloberg@humonc.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufLQiEOdgcCQ42jzFLh07-EpkkQCtKIRLZDOLYHnWsE942yFR7niR9YSUz1VGmH6Jg | ||||||||||
| 09/01/2022 | afowler@uwhealth.org | Amy | Fowler | MD, PhD | Assistant Professor | Radiology | Breast Imaging and Intervention | Medical Physics | Role of Imaging in Evaluation of Breast Pain | The project consists of a literature review culminating in an imaging-rich manuscript of the spectrum of causes of breast pain, clinical presentation, radiological imaging features, and management. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ | 1 | Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of breast pain. Images from case examples have been collected and will need to be organized as figures in the manuscript. | A moderate degree of independence is required for completion of this project. | Strong work ethic, reliability, and enthusiasm for the project | N/A | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students, UW undergraduates interested in research | Yes | N/A | No | Role of Imaging in Evaluation of Breast Pain: The project consists of a literature review culminating in an imaging-rich manuscript of the spectrum of causes of breast pain, clinical presentation, radiological imaging features, and management. https://www.radiology.wisc.edu/research/research-labs-and-groups/fowler-research-group/ ____________________________________________________________________________ Role - Under the supervision of the project mentor, the student will design and perform a literature review on the causes, clinical presentation, radiological imaging features, and management of breast pain. Images from case examples have been collected and will need to be organized as figures in the manuscript.; IRB Status - N/A; Skills - Strong work ethic, reliability, and enthusiasm for the project | Amy Fowler, afowler@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufiGxpGSSyx5b8GhwOEZFX8UdpuYrLaVWeoe67VsZggWfLcjGkdPPzlsohgJuxeQDs | |||||||||
| 16/12/2021 | ying.ge@wisc.edu | Ying | Ge | PhD | Professor | 6.082.654.744 | Cell and Regenerative Biology | An Accurate and Comprehensive Cardiac Troponin I Assay Enabled by Nanoproteomics | Acute myocardial infarction (AMI) due to obstructive coronary artery disease is a common reason for emergency care in the United States. Cardiac troponin I (cTnI) is a ‘gold-standard’ protein biomarker to identify AMI because it is specific to cardiac tissue and is released into the bloodstream following cardiac injury. Circulating cTnI in the blood exists in low abundance and in myriad ‘proteoforms’ that are known to reflect pathophysiological processes. The currently used diagnostics for cTnI are still incapable of distinguishing between all the cTnI proteoforms found in circulating blood, which may lead to unnecessary invasive procedures, or alternatively, treatment delays due to mis-diagnoses. Thus, there is an urgent need to develop a comprehensive and accurate proteoform-resolved clinical cTnI assay that can detect all cTnI proteoforms in blood for improved diagnosis of cardiovascular diseases. Recently, we have made a major methodologic breakthrough that enables analysis of all cTnI proteoforms from human serum at clinically relevant concentrations for the first time. Building upon our successful top-down MS-based analysis of cTnI from human serum, our goal is to expand the assay’s clinical utility for more accurate diagnosis of AMI. | 0 | The student is expected to 1) analyze the genotyping data and clinical information; 2) work closely with other members in the group to integrate the clinical data, genotyping data with proteomics data, which will be used to stratify patients into sub-groups to aid dissection of the molecular mechanisms underlying cardiac disease. | MD will work together with senior members in my group | Basic biochemistry and biology skills | Approved | Yes | Yes | Yes | Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students | No | Colleen Dickey |
No | An Accurate and Comprehensive Cardiac Troponin I Assay Enabled by Nanoproteomics: Acute myocardial infarction (AMI) due to obstructive coronary artery disease is a common reason for emergency care in the United States. Cardiac troponin I (cTnI) is a ‘gold-standard’ protein biomarker to identify AMI because it is specific to cardiac tissue and is released into the bloodstream following cardiac injury. Circulating cTnI in the blood exists in low abundance and in myriad ‘proteoforms’ that are known to reflect pathophysiological processes. The currently used diagnostics for cTnI are still incapable of distinguishing between all the cTnI proteoforms found in circulating blood, which may lead to unnecessary invasive procedures, or alternatively, treatment delays due to mis-diagnoses. Thus, there is an urgent need to develop a comprehensive and accurate proteoform-resolved clinical cTnI assay that can detect all cTnI proteoforms in blood for improved diagnosis of cardiovascular diseases. Recently, we have made a major methodologic breakthrough that enables analysis of all cTnI proteoforms from human serum at clinically relevant concentrations for the first time. Building upon our successful top-down MS-based analysis of cTnI from human serum, our goal is to expand the assay’s clinical utility for more accurate diagnosis of AMI. ____________________________________________________________________________ Role - The student is expected to 1) analyze the genotyping data and clinical information; 2) work closely with other members in the group to integrate the clinical data, genotyping data with proteomics data, which will be used to stratify patients into sub-groups to aid dissection of the molecular mechanisms underlying cardiac disease. ; IRB Status - Approved; Skills - Basic biochemistry and biology skills | Ying Ge, ying.ge@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufsVhU6PHesputwJzgqBTAG-Ar5jahBK8-TOhRyA0lUHKYAiqc7tJvc3bNd5icUODk | ||||||||||
| 22/12/2021 | bgillick@wisc.edu | Bernadette | Gillick | PhD, MSPT, PT | Associate Professor | 608 | Pediatrics | Dev Peds & Rehab Medicine | Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development | The overall NIH R01 funded study will assess, over the first two years of life, concurrent recovery and development of the infant brain and resultant function after perinatal stroke. The student project will surround a foundational aspect at one timepoint within our novel longitudinal study investigating the relationship between MRI and non-invasive brain stimulation using transcranial magnetic stimulation to assess cortical mapping and neurophysiologic response as biomarkers of recovery and development after early brain injury. | 0 | Direct infant/family participant interaction as well as procurement/analysis/processing of MRI and TMS/EMG data. | Continuous collaboration/teamwork with opportunity for independent data analysis. | Experience in coding (MATLAB) is preferred but not required. | Approved and Recruiting Commences January 2022 | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Dr. Catarina Saiote, saiote@wisc.edu, Dr. Ellen Sutter, ensutter@wisc.edu | Unsure / Depends | Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development: The overall NIH R01 funded study will assess, over the first two years of life, concurrent recovery and development of the infant brain and resultant function after perinatal stroke. The student project will surround a foundational aspect at one timepoint within our novel longitudinal study investigating the relationship between MRI and non-invasive brain stimulation using transcranial magnetic stimulation to assess cortical mapping and neurophysiologic response as biomarkers of recovery and development after early brain injury. ____________________________________________________________________________ Role - Direct infant/family participant interaction as well as procurement/analysis/processing of MRI and TMS/EMG data.; IRB Status - Approved and Recruiting Commences January 2022; Skills - Experience in coding (MATLAB) is preferred but not required. | Bernadette Gillick, bgillick@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucncOOCvwkrUHtjh902BdpCeuw6Iazb-VYdM2_wRWmBbzE-k1YFyST-6pBlmcL_vfg | |||||||||
| 30/01/2022 | glidehurst@humonc.wisc.edu | Carri | Glide-Hurst | PhD | Director of Radiation Oncology Physics | Human Oncology | Medical Physics | Cardio-oncology applications in radiation therapy | Cardiac toxicity is a devastating complication of cancer treatment and occurs during, shortly after, or even many years after treatment. Radiation dose to the left anterior descending coronary artery has been linked to an increased risk of radiation-induced cardiac morbidity, myocardial infarction, and development of coronary artery calcifications (CACs). While gender, age, family history, social, and health factors contribute to the overall profile of cardiovascular risks, CAC burden is also significantly associated with the occurrence of major cardiovascular events. At present, CAC quantification is performed on high resolution ECG-gated CT exams for patients who have been identified as intermediate or high risk of having a cardiac event. The standard of care for CAC quantification is typically semi-automatic, where a radiologist draws a bounding box around the coronary arteries and thresholds the image to yield a quantitative value. Automated CAC approaches have been challenging, relying on proper localization of the heart and discrimination of other high density objects within the CT scan. Prior to the start of RT, patients undergo a treatment planning computed tomography (TPCT) which is used to delineate the tumor and organs at risk such as the heart, to uniquely tailor RT plans to each individual patient’s anatomy for optimal sparing. Although these imaging data are available, at present, they are not being evaluated for CACs that are clearly visible on the TPCTs. By quantifying both the presence and severity of CACs on these standard scans, radiation oncologists may be provided with powerful information on risk stratification to enable preferential sparing of the heart in high risk populations. This work will focus on annotating CACs on TPCTs for future development of a deep learning model for automated CAC quantification for future cancer patients. | 1 | CT image annotation, curate data, analysis, working with study team to develop and validate deep learning models | Excel, basic understanding of anatomy | Approved | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | PhD students, UW undergraduates interested in research | No | N/A | No | Cardio-oncology applications in radiation therapy: Cardiac toxicity is a devastating complication of cancer treatment and occurs during, shortly after, or even many years after treatment. Radiation dose to the left anterior descending coronary artery has been linked to an increased risk of radiation-induced cardiac morbidity, myocardial infarction, and development of coronary artery calcifications (CACs). While gender, age, family history, social, and health factors contribute to the overall profile of cardiovascular risks, CAC burden is also significantly associated with the occurrence of major cardiovascular events. At present, CAC quantification is performed on high resolution ECG-gated CT exams for patients who have been identified as intermediate or high risk of having a cardiac event. The standard of care for CAC quantification is typically semi-automatic, where a radiologist draws a bounding box around the coronary arteries and thresholds the image to yield a quantitative value. Automated CAC approaches have been challenging, relying on proper localization of the heart and discrimination of other high density objects within the CT scan. Prior to the start of RT, patients undergo a treatment planning computed tomography (TPCT) which is used to delineate the tumor and organs at risk such as the heart, to uniquely tailor RT plans to each individual patient’s anatomy for optimal sparing. Although these imaging data are available, at present, they are not being evaluated for CACs that are clearly visible on the TPCTs. By quantifying both the presence and severity of CACs on these standard scans, radiation oncologists may be provided with powerful information on risk stratification to enable preferential sparing of the heart in high risk populations. This work will focus on annotating CACs on TPCTs for future development of a deep learning model for automated CAC quantification for future cancer patients. ____________________________________________________________________________ Role - CT image annotation, curate data, analysis, working with study team to develop and validate deep learning models; IRB Status - Approved; Skills - Excel, basic understanding of anatomy | Carri Glide-Hurst, glidehurst@humonc.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucqfldJFyLTMVVbSFK2apLT2nvK8kLsfzZMZwghHGvvAr6htHE7KV1gHeszCMes74k | |||||||||||
| 23/01/2022 | rglinert@dermatology.wisc.edu | Robert | Glinert | MD | Clinical Professor | 608 | Dermatology | Mohs Appropriate Use CriteriaL As applied to Nonmelanoma Skin Cancers at the University of Wisconsin | In 2012 appropriate use criteria (AUC) for Mohs micrographic surgery were defined via a consensus collaboration of dermatology organizations including the American College of Mohs Surgery. . To date there has been only one 2015 study which has looked at how these criteria are actually used in clinical practice. This study will be a three month retrospective study. We will review charts from all newly diagnosed cases of non-melanoma skin cancer (NMSC) cases at the university. Based on lesion size, location and histology each case will be assigned an AUC score to determine appropriateness of Mohs surgery. From this we will learn what percent of newly diagnosed cases of NMSC are appropriate for Mohs surgery. We will also look at data on how many cases that are appropriate for Mohs are treated by other modalities. We will also review how many cases not appropriate for Mohs using AUC criteria are treated via Mohs. | 2 | The student will review the chart including the clinical description of the lesion and the pathology report, and based on the provided information will assign an AUC score for each lesion. The student will tabulate based on AUC, how many patients qualified for Mohs surgery, and how each lesion was actually treated. | Moderate to high degree of independence | Ability to review chart and understand | I am not sure if IRB approval is required. | No | No (plan to use Dean's Office Funds) | No | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | n/a | No | Mohs Appropriate Use CriteriaL As applied to Nonmelanoma Skin Cancers at the University of Wisconsin: In 2012 appropriate use criteria (AUC) for Mohs micrographic surgery were defined via a consensus collaboration of dermatology organizations including the American College of Mohs Surgery. . To date there has been only one 2015 study which has looked at how these criteria are actually used in clinical practice. This study will be a three month retrospective study. We will review charts from all newly diagnosed cases of non-melanoma skin cancer (NMSC) cases at the university. Based on lesion size, location and histology each case will be assigned an AUC score to determine appropriateness of Mohs surgery. From this we will learn what percent of newly diagnosed cases of NMSC are appropriate for Mohs surgery. We will also look at data on how many cases that are appropriate for Mohs are treated by other modalities. We will also review how many cases not appropriate for Mohs using AUC criteria are treated via Mohs. ____________________________________________________________________________ Role - The student will review the chart including the clinical description of the lesion and the pathology report, and based on the provided information will assign an AUC score for each lesion. The student will tabulate based on AUC, how many patients qualified for Mohs surgery, and how each lesion was actually treated. ; IRB Status - I am not sure if IRB approval is required. ; Skills - Ability to review chart and understand | Robert Glinert, rglinert@dermatology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueqeCvzoLcuL-c_XHiqLotDNoelcaitz8z_NZsZrAifZZ0acTQMHztYjGSm7jjrZW8 | ||||||||||
| 10/01/2022 | agrayev@uwhealth.org | Allison | Grayev | MD | Assoc Professor | Radiology | Neuroradiology | Anthony Kuner, MD | AKuner@uwhealth.org | Radiology | Neuroradiology | Learning Spine - Anatomy | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | 0 | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | Access to PACS to be able to pull cases | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | Yes | Lorene Seman lseman@uwhealth.org | No | Learning Spine - Anatomy: Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. ____________________________________________________________________________ Role - Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development.; IRB Status - N/A; Skills - Access to PACS to be able to pull cases | Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner, MD AKuner@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuelbgytuC4WLNLWFlhEfNJgElBv9HRoyMk75lJefus8lO1CoQUvmNS0snk_lHduEgE | |||||||
| 10/01/2022 | agrayev@uwhealth.org | Allison | Grayev | MD | Assoc Professor | Radiology | Neuroradiology | Anthony Kuner MD | AKuner@uwhealth.org | Radiology | Neuroradiology | Learning Spine - Intramedullary | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | 0 | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | Able to use PACS to pull images | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | Yes | Lorene Seman LSeman@uwhealth.org | No | Learning Spine - Intramedullary: Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. ____________________________________________________________________________ Role - Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development.; IRB Status - N/A; Skills - Able to use PACS to pull images | Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner MD AKuner@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudl3cYDijOn7p89Joq44iizbOt4Nd_pYdjngIiy2pxCgtEzonPFuv8QvacKAw4Ljbc | |||||||
| 10/01/2022 | AGrayev@uwhealth.org | Allison | Grayev | MD | Assoc Prof | Radiology | Neuroradiology | Anthony Kuner MD | AKuner@uwhealth.org | Radiology | Neuroradiology | Learning Spine - Extramedullary | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | 0 | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | Able to pull images from PACS | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | Yes | Lorene Seman LSeman@uwhealth.org | No | Learning Spine - Extramedullary: Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. ____________________________________________________________________________ Role - Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development.; IRB Status - N/A; Skills - Able to pull images from PACS | Allison Grayev, AGrayev@uwhealth.org -- Co-Mentor: Anthony Kuner MD AKuner@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuexRPJWVyal15CKY8O9BRNiBQXxVluMF7rCRQ89x_CiHA0_M_USUxaCg2wdm9q-em4 | |||||||
| 10/01/2022 | AGrayev@uwhealth.org | Allison | Grayev | MD | Assoc Prof | Radiology | Neuroradiology | Anthony Kuner MD | AKuner@uwhealth.org | Radiology | Neuroradiology | Learning Spine - Extradural | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | 0 | Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. | Able to pull images from PACS | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | Yes | Lorene Seman LSeman@uwhealth.org | No | Learning Spine - Extradural: Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development. ____________________________________________________________________________ Role - Students will be responsible for collating and creating case based educational modules for the department’s Learning Spine website. Questions will be used to assess participants understanding of the material before and after viewing the materials. This data will be used to inform best practices for future module development.; IRB Status - N/A; Skills - Able to pull images from PACS | Allison Grayev, AGrayev@uwhealth.org -- Co-Mentor: Anthony Kuner MD AKuner@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucWPmB-61_sRTrCJeHDDqnIyDI3o6thiLZrz8NA4BUY29Z0n9tdEnariqYg2ZNuaFo | |||||||
| 19/01/2022 | grimes@urology.wisc.edu | Matthew | Grimes | MD | Assistant Professor | 5.094.324.615 | Urology | Alterations in Collagen Structure in Lichen Sclerosus | Lichen sclerosus is a poorly understood inflammatory condition of the genital skin which is associated with severe urethral strictures in affected men. Reconstructive surgery is the only hope for definitive cure, however fails in more than 50% of cases. The etiology of this disease is unknown which precludes therapeutic advances – specifically development of minimally invasive alternatives to morbid surgery. This project is part of a larger NIH funded proposal to probe a specific molecular pathway in the pathogenesis of fibrosis in lichen sclerosus. This summer project would focus on characterization of collagen structure in human lichen sclerosus tissues using both standard histochemical methods and microscopy as well as second harmonic generation microscopy in collaboration with Dr. Campagnola in the Biomedical Engineering Department at UW-Madison. Specific responsibilities include performing staining and microscopic analysis of previously obtained tissue and limited collection of relevant clinical data from the medical record. Students will have the opportunity to submit and present the findings at regional and national meetings as well as submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests. My most recent Shapiro Scholar has presented his work at multiple national meetings and is currently finalizing a manuscript for submission. | 1 | Perform staining, microscopy, and analysis of human tissues. Construction of a clinical database including limited collection of clinical data from the medical record. Will work closely with the mentor to perform data analysis and reporting of the results through meeting presentation and manuscript submission. | Experience with immunohistochemical methods preferred but not required | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | N/A | No | Alterations in Collagen Structure in Lichen Sclerosus: Lichen sclerosus is a poorly understood inflammatory condition of the genital skin which is associated with severe urethral strictures in affected men. Reconstructive surgery is the only hope for definitive cure, however fails in more than 50% of cases. The etiology of this disease is unknown which precludes therapeutic advances – specifically development of minimally invasive alternatives to morbid surgery. This project is part of a larger NIH funded proposal to probe a specific molecular pathway in the pathogenesis of fibrosis in lichen sclerosus. This summer project would focus on characterization of collagen structure in human lichen sclerosus tissues using both standard histochemical methods and microscopy as well as second harmonic generation microscopy in collaboration with Dr. Campagnola in the Biomedical Engineering Department at UW-Madison. Specific responsibilities include performing staining and microscopic analysis of previously obtained tissue and limited collection of relevant clinical data from the medical record. Students will have the opportunity to submit and present the findings at regional and national meetings as well as submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests. My most recent Shapiro Scholar has presented his work at multiple national meetings and is currently finalizing a manuscript for submission. ____________________________________________________________________________ Role - Perform staining, microscopy, and analysis of human tissues. Construction of a clinical database including limited collection of clinical data from the medical record. Will work closely with the mentor to perform data analysis and reporting of the results through meeting presentation and manuscript submission.; IRB Status - Approved; Skills - Experience with immunohistochemical methods preferred but not required | Matthew Grimes, grimes@urology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue2GxKD4iAm5NQ5vXe89CMxF0SMmYsT_VwWB8jbnfUxWS3_jfxWoGyckEv1Ef2Cn24 | |||||||||||
| 19/01/2022 | grimesmatt@gmail.com | Matthew | Grimes | MD | Assistant Professor | 5.094.324.615 | Urology | Characterizing incidental prostate cancer diagnosed during benign prostate surgery | The UW Department of Urology is among the highest volume surgical centers globally for benign prostatic hyperplasia (BPH) - performing approximately 400 surgeries annually. In the last 5 years, we have adopted a different endoscopic technique called holmium laser enucleation of the prostate (HoLEP). This technique results in a more complete removal of the prostate adenoma and allows us to treat even very large glands endoscopically. Concordant with this shift in technique, we have noted a much higher rate of incidental detection of prostate cancer after HoLEP – which approaches 20% compared to about 5% noted in historical series using other techniques. Your summer project would focus on helping to develop a database of surgical patients in order to 1) precisely define the incidence of prostate cancer detection after HoLEP, 2) identify clinical factors associated with cancer diagnosis, and 3) characterize cancer management and outcome in incidentally detected tumors. This work both addresses an important knowledge gap in benign urology and may provide additional insight into prostate cancer epidemiology and biology. You would be working in an established research group within the NIH funded UW O’Brien Center for Benign Urology Research. Your primary mentor is committed to your success and has worked with multiple Shapiro Scholars all of which have gone on to present their work at national meetings and submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests. | 1 | Assist with development of a clinical database, data collection/analysis, and abstract/manuscript authorship. | Moderate.\ | Familiarity with Excel and EPIC are beneficial but not required | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | N/A | Yes | Characterizing incidental prostate cancer diagnosed during benign prostate surgery : The UW Department of Urology is among the highest volume surgical centers globally for benign prostatic hyperplasia (BPH) - performing approximately 400 surgeries annually. In the last 5 years, we have adopted a different endoscopic technique called holmium laser enucleation of the prostate (HoLEP). This technique results in a more complete removal of the prostate adenoma and allows us to treat even very large glands endoscopically. Concordant with this shift in technique, we have noted a much higher rate of incidental detection of prostate cancer after HoLEP – which approaches 20% compared to about 5% noted in historical series using other techniques. Your summer project would focus on helping to develop a database of surgical patients in order to 1) precisely define the incidence of prostate cancer detection after HoLEP, 2) identify clinical factors associated with cancer diagnosis, and 3) characterize cancer management and outcome in incidentally detected tumors. This work both addresses an important knowledge gap in benign urology and may provide additional insight into prostate cancer epidemiology and biology. You would be working in an established research group within the NIH funded UW O’Brien Center for Benign Urology Research. Your primary mentor is committed to your success and has worked with multiple Shapiro Scholars all of which have gone on to present their work at national meetings and submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests. ____________________________________________________________________________ Role - Assist with development of a clinical database, data collection/analysis, and abstract/manuscript authorship. ; IRB Status - Approved; Skills - Familiarity with Excel and EPIC are beneficial but not required | Matthew Grimes, grimesmatt@gmail.com -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufo366-vOWz4qjiSs_tVU_nQ6x0GvfeAegEGC9Wp9Tjbu5v1xW0WrI7PdqM6XiAOqs | ||||||||||
| 07/12/2021 | hellenbrand@neurosurgery.wisc.edu | Amgad | Hanna | MD | Associate Professor | 0 | Neurological Surgery | Dan Hellenbrand, Researcher III | hellenbrand@neurosurgery.wisc.edu | Neurological Surgery | Modulating inflammation after spinal cord injury | Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction. For this project, we will use a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI in a rat model. | 0 | The students will be involved in a lot of hands on surgeries and experiments. The rat surgeries include spinal cord contusion, electrophysiology, craniotomies for axon tracer injection, and perfusions. Other experiments include rat functional testing, sectioning spinal cord, and immunohistochemistry. The students will also be involved in manuscript writing. | The student will usually work directly with Dan Hellenbrand and a team of students, but sometimes will be working independently. | You are not expected to have surgery experience. We will teach these surgeries in lab. Student should be proficient in writing. | n/a | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | No | hellenbrand@neurosurgery.wisc.edu | No | Modulating inflammation after spinal cord injury: Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction. For this project, we will use a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI in a rat model. ____________________________________________________________________________ Role - The students will be involved in a lot of hands on surgeries and experiments. The rat surgeries include spinal cord contusion, electrophysiology, craniotomies for axon tracer injection, and perfusions. Other experiments include rat functional testing, sectioning spinal cord, and immunohistochemistry. The students will also be involved in manuscript writing.; IRB Status - n/a; Skills - You are not expected to have surgery experience. We will teach these surgeries in lab. Student should be proficient in writing. | Amgad Hanna, hellenbrand@neurosurgery.wisc.edu -- Co-Mentor: Dan Hellenbrand, Researcher III hellenbrand@neurosurgery.wisc.edu | |||||||
| 07/12/2021 | mwharer@wisc.edu | Matthew | Harer | MD | Assistant Professor of Neonatology | 608 | Pediatrics | Neonatology | Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU | This project will involve two different types of research. Prospective recruitment for an ongoing clinical trial in the NICU and a chart review/analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. https://www.pediatrics.wisc.edu/research/research-groups/harer/ | 0 | The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad. | This project will be flexible with time requirements. Students will work closely with a Neonatal Fellow and Assistant Professor Attending, meeting multiple times per week. The student will also have the opportunity to shadow in the NICU. | None - Interest in Pediatrics or Neonatology preferred | Approved | Wisconsin Partnership Program; ICTR KL2 Pending | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | UW undergraduates interested in research | 1. Harer MW, Adegboro, CO, Richard, L, McAdams, RM. Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury. Pediatr Nephrol. 2020. Published online. 2. Harer MW, Chock VY. Renal Tissue Oxygenation Monitoring-An Opportunity to Improve Kidney Outcomes in the Vulnerable Neonatal Population. Front Pediatr. 2020;8:241. PMID: 32528917; PMCID: PMC7247835. 3. Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study. JAMA Pediatr. 2018 Jun 4;172(6):e180322. PMID: 29610830; PMCID: PMC6137530. 4. Harer MW, Charlton JR, Tipple TE, Reidy KJ. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes. J Perinatol. 2020 Apr 10; PMID: 32277164. 5. Harer MW, Pope CF, Conaway MR, Charlton JR. Follow-up of Acute kidney injury in Neonates during Childhood Years (FANCY): a prospective cohort study. 2017 Jun;32(6):1067-1076. PMID: 28255805. | No | N/A | No | Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU: This project will involve two different types of research. Prospective recruitment for an ongoing clinical trial in the NICU and a chart review/analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. https://www.pediatrics.wisc.edu/research/research-groups/harer/ ____________________________________________________________________________ Role - The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad.; IRB Status - Approved; Skills - None - Interest in Pediatrics or Neonatology preferred | Matthew Harer, mwharer@wisc.edu -- Co-Mentor: | |||||||||
| 23/11/2021 | hryckowian@medicine.wisc.edu | Andrew | Hryckowian | PhD | Assistant Professor | 17.249.722.201 | Medicine | Gastroenterology and Hepatology | Medical Microbiology & Immunology | Serum uric acid and Clostridioides difficile infection and recurrence | We are interested to know, via retrospective chart review of individuals who have had serum uric acid quantified, whether elevated uric acid levels are correlated with incidence of C. difficile infection and recurrence. | 1 | Conduct retrospective chart reviews on medical records collected at UW Health and apply relevant statistical methods. | Must be familiar with patient data collection and how to access variables relevant to this study | Application for IRB approval to be submitted. | PI is currently funded through his startup package. | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | PhD students | N/A. This is a new direction of research in our lab and this RCR will help to inform investigations on the impacts of uric acid on C. difficile biology in controlled experimental systems (e.g. cell culture and murine models of infection). | Yes | N/A | Yes | Serum uric acid and Clostridioides difficile infection and recurrence: We are interested to know, via retrospective chart review of individuals who have had serum uric acid quantified, whether elevated uric acid levels are correlated with incidence of C. difficile infection and recurrence. ____________________________________________________________________________ Role - Conduct retrospective chart reviews on medical records collected at UW Health and apply relevant statistical methods. ; IRB Status - Application for IRB approval to be submitted. ; Skills - Must be familiar with patient data collection and how to access variables relevant to this study | Andrew Hryckowian, hryckowian@medicine.wisc.edu -- Co-Mentor: | |||||||||
| 17/12/2021 | laura.jacques@wisc.edu | Laura | Jacques | MD | Assistant professor Obstetrics & Gynecology | Obstetrics & Gynecology | ASOG | Name and Shame-What medical students are looking for in an ObGyn Residency: : A qualitative analysis of social media posts | Third year medical students applying to ObGyn residency often post comments about different residency programs on a social media site called "Name and Shame". We aim to identify factors students consider when applying to and ranking ObGyn residencies as well evaluate student impressions of the interview process. We will review the posts and apply inductive and deductive qualitative methods to generate codes and then themes. | 1 | Student(s) will work with 2 MD-PhD students reviewing posts, generating codes in NVivo (A software program we can train you to use) and identifying themes. | There will be consistent oversight and mentorship from the PI as well as the MD PhD students in the lab | Experience with qualitative coding preferred but not required | In process-will be completed prior to student start | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students | Yes | Andrea Zorbas. zorbas@wisc.edu | No | Name and Shame-What medical students are looking for in an ObGyn Residency: : A qualitative analysis of social media posts: Third year medical students applying to ObGyn residency often post comments about different residency programs on a social media site called "Name and Shame". We aim to identify factors students consider when applying to and ranking ObGyn residencies as well evaluate student impressions of the interview process. We will review the posts and apply inductive and deductive qualitative methods to generate codes and then themes. ____________________________________________________________________________ Role - Student(s) will work with 2 MD-PhD students reviewing posts, generating codes in NVivo (A software program we can train you to use) and identifying themes. ; IRB Status - In process-will be completed prior to student start; Skills - Experience with qualitative coding preferred but not required | Laura Jacques, laura.jacques@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf00BVyjvlLwzkysI7gTE6JmQ3beaBn6RRT5lb5bZsvis9Wq2Qqtq3XVcapyxWjVB8 | ||||||||||
| 22/12/2021 | jarrard@urology.wisc.edu | David | Jarrard | MD | Professor Urology, Associate Director Carbone Cancer Center | 6.083.325.518 | Urology | Impact and biology of neoadjuvant androgen deprivation therapy on high risk prostate cancer prior to radical prostatectomy | Prostate cancer is responsive to androgens and neoadjuvant treatment with androgen deprivation therapy is used commonly during radiation therapy. During the pandemic, a number of patients were placed on ADT for several months prior to deferred surgery. This project will assess the clinicopathologic outcomes of a series of patients placed on ADT prior to deferred surgery in this modern series. In addition, our laboratory has extensively studied the biologic response to ADT. The candidate will also assess RNA-seq data in a series of microdissected high grade and ADT treated prostate cancer patients to identify signaling pathways that are commonly altered with ADT. This data will have implications regarding synergistic approaches to improve androgen deprivation therapy and outcomes in advanced prostate cancer therapy. | 0 | chart review and assisting in expression data analysis | Moderate, we are here to mentor however | enthusiasm, some knowledge of statistics and programming a plus | approved | Yes | Yes | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | PhD students, UW undergraduates interested in research | No | Steve Hall Hall@urology.wisc.edu | No | Impact and biology of neoadjuvant androgen deprivation therapy on high risk prostate cancer prior to radical prostatectomy: Prostate cancer is responsive to androgens and neoadjuvant treatment with androgen deprivation therapy is used commonly during radiation therapy. During the pandemic, a number of patients were placed on ADT for several months prior to deferred surgery. This project will assess the clinicopathologic outcomes of a series of patients placed on ADT prior to deferred surgery in this modern series. In addition, our laboratory has extensively studied the biologic response to ADT. The candidate will also assess RNA-seq data in a series of microdissected high grade and ADT treated prostate cancer patients to identify signaling pathways that are commonly altered with ADT. This data will have implications regarding synergistic approaches to improve androgen deprivation therapy and outcomes in advanced prostate cancer therapy. ____________________________________________________________________________ Role - chart review and assisting in expression data analysis; IRB Status - approved; Skills - enthusiasm, some knowledge of statistics and programming a plus | David Jarrard, jarrard@urology.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudRChTegSFb-s6PuGyqg4rlVPsnhu_M8e0e3HEfH9diry-w24FS8i3xRiSJiYPaZcs | ||||||||||
| 04/01/2022 | jungs@surgery.wisc.edu | Sarah | Jung | PhD | Assistant Professor | 16.082.621.240 | Surgery | Education | Neil Salyapongse | ASalyapongse@uwhealth.org | Surgery | Plastic and Reconstructive Surgery | Using Natural Language Processing to Study Bias in Letters of Recommendation for Plastic Surgery | Letters of recommendation for plastic surgery programs will be analyzed for bias using multiple natural language processing techniques | 1 | The student researcher will assist with the literature review, data analysis, and writing of an abstract and paper. | No advanced skills required | Not yet completed | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | DPT students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | Sarah Pavao - pavao@surgery.wisc.edu | No | Using Natural Language Processing to Study Bias in Letters of Recommendation for Plastic Surgery: Letters of recommendation for plastic surgery programs will be analyzed for bias using multiple natural language processing techniques ____________________________________________________________________________ Role - The student researcher will assist with the literature review, data analysis, and writing of an abstract and paper. ; IRB Status - Not yet completed; Skills - No advanced skills required | Sarah Jung, jungs@surgery.wisc.edu -- Co-Mentor: Neil Salyapongse ASalyapongse@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucEFTiCSPMI1k3_ZUtJJRdJirgAKENDwWxhM08WlwS-BOMGBBS4GMBxVSeeSE4KW1w | ||||||
| 03/01/2022 | michelle.kelly@wisc.edu | Michelle | Kelly | MD, MS | Associate Professor | 2.154.101.528 | Pediatrics | Pediatric Hospital Medicine | Pediatric Inpatient OpenNotes Toolkit | Physicians are now required to share their daily notes with families of hospitalized children. However, many still struggle with how to write notes that are helpful for both families and the healthcare team. The goal of this summer project is to create an online toolkit to promote best practices for sharing physicians' notes with families during their child's hospital stay. The toolkit will include tips and tools for children's hospitals, such as a Powtoon’s video introducing notes to families and sample note templates and educational training materials for inpatient providers. In collaboration with the Pediatric OpenNotes Collaborative, this toolkit will be published on OpenNotes.org, among other sites. | 1 | Development and refinement of toolkit content | The student will lead the refinement of toolkit content and design. | Good writing skills, ideally for the general public. Detail-oriented. Creativity a plus. | N/A | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | DPT students, MPH students, PhD students, UW undergraduates interested in research | Yes | N/A | Yes | Pediatric Inpatient OpenNotes Toolkit: Physicians are now required to share their daily notes with families of hospitalized children. However, many still struggle with how to write notes that are helpful for both families and the healthcare team. The goal of this summer project is to create an online toolkit to promote best practices for sharing physicians' notes with families during their child's hospital stay. The toolkit will include tips and tools for children's hospitals, such as a Powtoon’s video introducing notes to families and sample note templates and educational training materials for inpatient providers. In collaboration with the Pediatric OpenNotes Collaborative, this toolkit will be published on OpenNotes.org, among other sites. ____________________________________________________________________________ Role - Development and refinement of toolkit content; IRB Status - N/A; Skills - Good writing skills, ideally for the general public. Detail-oriented. Creativity a plus. | Michelle Kelly, michelle.kelly@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueznDB82M6fREB4NgI-Dow4-dM-eJVWzrNreGJ9T7XfeZoKp7Mn9wUFo4y1myc5uPg | |||||||||
| 07/12/2021 | cakelm@wisc.edu | Cindi | Kelm-Nelson | PhD | Scientist III | 608 | Surgery | Otolaryngology | Biomarkers in prodromal Parkinson disease | Our lab uses genetic rodent models of Parkinson disease to better understand disease in the preclinical phase. There are multiple ongoing studies that the student would be able to participate in depending on their interests. Research techniques include: XCLARITY, cell culture, RNA sequencing, rat and mouse behavioral collection, PCR, Western blots, ELISA, IHC/IF. The ‘summer of 2022’ will likely include opportunities for vocal fold injections in the rat as well as drug repurposing in vitro studies. | 1 | Conduct basic science experiments and data collection. Depending upon progress, there would be a strong possibility of a co-authorship on a future manuscript. | Moderate: after the training period, the student would be working independently. We are a small research group that is willing to train as much as needed. | Basic knowledge of laboratory skills and data collection. The student will need to take several safety and training courses to work in the lab. Most of these courses are online with the Rat Handling course being in person through RARC. | N/A | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, UW undergraduates interested in research | No | No | Sarah Lechner (slechner@wisc.edu) | No | Biomarkers in prodromal Parkinson disease: Our lab uses genetic rodent models of Parkinson disease to better understand disease in the preclinical phase. There are multiple ongoing studies that the student would be able to participate in depending on their interests. Research techniques include: XCLARITY, cell culture, RNA sequencing, rat and mouse behavioral collection, PCR, Western blots, ELISA, IHC/IF. The ‘summer of 2022’ will likely include opportunities for vocal fold injections in the rat as well as drug repurposing in vitro studies. ____________________________________________________________________________ Role - Conduct basic science experiments and data collection. Depending upon progress, there would be a strong possibility of a co-authorship on a future manuscript.; IRB Status - N/A; Skills - Basic knowledge of laboratory skills and data collection. The student will need to take several safety and training courses to work in the lab. Most of these courses are online with the Rat Handling course being in person through RARC. | Cindi Kelm-Nelson, cakelm@wisc.edu -- Co-Mentor: | |||||||||
| 08/12/2021 | pkling@wisc.edu | Pamela | Kling | MD | Professor of Pediatrics | 608 | Pediatrics | Neonatal-Perinatal Medicine | Michael Fritsch | mkfritsch@wisc.edu | Pathology and Laboratory Medicine | Communicating Placental Pathology Data between Pathology, Mother and Baby Providers | We are presenting what is a hybrid project that will combine both aspects of quality improvement and original research, essentially an implementation project. The quality improvement goal is to facilitate 3-way bidirectional communication between Pathology, Obstetrics and Pediatrics relating to placental pathology. The research goal is to generate a dataset that examines rates of common placental pathological diagnoses of women delivering at UnityPoint Health Meriter. The student will work with providers in Pathology at UW (Dr. Frisch and Dr. Bockoven), Meriter Pathology (Dr. Sarda) and Perinatal-Neonatal provider, Dr. Kling, as well as others. Currently, UW-Health deliveries occur at their partner hospital, UnityPoint Health Meriter, a regional referral center with the largest number of deliveries in Wisconsin (50% of deliveries are high-risk and 33% are extremely high-risk deliveries). Guidelines recommend Pathology placental exams in high-risk deliveries; i.e., prematurity, infection, intrauterine growth restriction, maternal diseases such as preeclampsia, and others. Diagnosing pathologies in the placenta may improve postpartum care for the mother and facilitate counseling for both subsequent pregnancies and long-term health conditions. Likewise, diagnosing pathologies in the placenta may improve both immediate neonatal care and facilitate counseling for long-term conditions in the child. We plan to assess barriers and develop strategies to better communicate clinical data to the Pathologist team and to communicate pathology results to both sets (Pediatric and Obstetrics) of care providers. Obstetric data are electronically linked to child charts prior to delivery, but less so post-delivery. Barriers also include that most deliveries do not remain in the UnityPoint Health system for maternal-child post discharge care. Communication barriers include lab software to medical record software and software from two different health systems. Activities for the medical student researcher would be observe high-risk obstetricians, pediatric providers, and pathologists to develop a needs assessment for each group. The student researcher will learn about maternal clinical conditions, pregnancy complications, NICU care, placental anatomy, histology, and pathology. The student will learn about the Amsterdam Placental Workshop Group Consensus Pathology Criteria. The student will learn about interpreting these placental pathology results within the context of high-risk obstetrical conditions and neonatal diagnoses. Recent quality improvement efforts between Pathology, Obstetrics, and Pediatrics have doubled the rates of ordering placental exams in Pathology to 1350 placentas annually. Meriter has 5000 deliveries annually, about 25% of all placentas are now studied. Logistical and technical problems are being addressed in both the clinical settings and in the Pathology Department. Using these newly generated placental data, a placental pathology dataset will be developed for ongoing quality improvement and research goals of these departments. | 0 | Data collection and data set generation, data analysis, shadowing providers, developing needs assessments, coordinating with investigators, presenting at research/quality meetings, manuscript writing. | Both supervised aspects and independent aspects | Curiosity, problem-solving, familiarity with Epic, excel, datasets, may need to learn RedCap. | Will be exempt as a Quality Inititative. | Meriter Foundation | Yes | Yes | Research Electives for credit | Genetic Counseling students, UW undergraduates interested in research | No | Yes | Kim Stevenson for 50% Peds Funding: kdstevenson@pediatrics.wisc.edu | Yes | Communicating Placental Pathology Data between Pathology, Mother and Baby Providers: We are presenting what is a hybrid project that will combine both aspects of quality improvement and original research, essentially an implementation project. The quality improvement goal is to facilitate 3-way bidirectional communication between Pathology, Obstetrics and Pediatrics relating to placental pathology. The research goal is to generate a dataset that examines rates of common placental pathological diagnoses of women delivering at UnityPoint Health Meriter. The student will work with providers in Pathology at UW (Dr. Frisch and Dr. Bockoven), Meriter Pathology (Dr. Sarda) and Perinatal-Neonatal provider, Dr. Kling, as well as others. Currently, UW-Health deliveries occur at their partner hospital, UnityPoint Health Meriter, a regional referral center with the largest number of deliveries in Wisconsin (50% of deliveries are high-risk and 33% are extremely high-risk deliveries). Guidelines recommend Pathology placental exams in high-risk deliveries; i.e., prematurity, infection, intrauterine growth restriction, maternal diseases such as preeclampsia, and others. Diagnosing pathologies in the placenta may improve postpartum care for the mother and facilitate counseling for both subsequent pregnancies and long-term health conditions. Likewise, diagnosing pathologies in the placenta may improve both immediate neonatal care and facilitate counseling for long-term conditions in the child. We plan to assess barriers and develop strategies to better communicate clinical data to the Pathologist team and to communicate pathology results to both sets (Pediatric and Obstetrics) of care providers. Obstetric data are electronically linked to child charts prior to delivery, but less so post-delivery. Barriers also include that most deliveries do not remain in the UnityPoint Health system for maternal-child post discharge care. Communication barriers include lab software to medical record software and software from two different health systems. Activities for the medical student researcher would be observe high-risk obstetricians, pediatric providers, and pathologists to develop a needs assessment for each group. The student researcher will learn about maternal clinical conditions, pregnancy complications, NICU care, placental anatomy, histology, and pathology. The student will learn about the Amsterdam Placental Workshop Group Consensus Pathology Criteria. The student will learn about interpreting these placental pathology results within the context of high-risk obstetrical conditions and neonatal diagnoses. Recent quality improvement efforts between Pathology, Obstetrics, and Pediatrics have doubled the rates of ordering placental exams in Pathology to 1350 placentas annually. Meriter has 5000 deliveries annually, about 25% of all placentas are now studied. Logistical and technical problems are being addressed in both the clinical settings and in the Pathology Department. Using these newly generated placental data, a placental pathology dataset will be developed for ongoing quality improvement and research goals of these departments. ____________________________________________________________________________ Role - Data collection and data set generation, data analysis, shadowing providers, developing needs assessments, coordinating with investigators, presenting at research/quality meetings, manuscript writing.; IRB Status - Will be exempt as a Quality Inititative.; Skills - Curiosity, problem-solving, familiarity with Epic, excel, datasets, may need to learn RedCap. | Pamela Kling, pkling@wisc.edu -- Co-Mentor: Michael Fritsch mkfritsch@wisc.edu | ||||||
| 20/01/2022 | jdkratz@medicine.wisc.edu | Jeremy | Kratz | MD | Assistant Professor | 734 | Medicine | Medical Oncology | Therapeutic Development in Primary Liver Cancer | Primary liver cancer has limited therapeutic options in the advanced setting with current strategies including chemotherapy and immunotherapy. Targeted therapeutics have improved clinical outcomes in other cancer types, however their development in hepatocellular carcinoma has lagged. This project involved broad therapeutic screening for pharmacologic agents in development for advanced cancer. Using cancer organoid models, a high throughput screen will be performed followed by validation of lead compounds identified from this screen. | 2 | Tissue Culture, Experimental Planning, Data analysis | None | Hardworking, team oriented, curious | Approved | Yes | Yes | Yes | Research Electives for credit | PhD students, UW undergraduates interested in research | No | Samantha Anderson (samantha.j.anderson@wisc.edu) Shahadat Hossan (mshossan@medicine.wisc.edu) | No | Therapeutic Development in Primary Liver Cancer: Primary liver cancer has limited therapeutic options in the advanced setting with current strategies including chemotherapy and immunotherapy. Targeted therapeutics have improved clinical outcomes in other cancer types, however their development in hepatocellular carcinoma has lagged. This project involved broad therapeutic screening for pharmacologic agents in development for advanced cancer. Using cancer organoid models, a high throughput screen will be performed followed by validation of lead compounds identified from this screen. ____________________________________________________________________________ Role - Tissue Culture, Experimental Planning, Data analysis; IRB Status - Approved; Skills - Hardworking, team oriented, curious | Jeremy Kratz, jdkratz@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuenGQwo_5zBecx5aZeI2XCLTfpwP5xPLkWiMYfbtZEZbvu4ouXud444A7kBvkTZbO0 | |||||||||
| 26/01/2022 | kruse@ortho.wisc.edu | Lisa | Kruse | MD | Assistant Professor of Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Hand Surgery | Music Interventions During Wide-Awake Hand Surgery a Randomized Controlled Trial | Patients who are planned to undergo wide awake (local only anesthetic hand surgery) will be randomized to either a music intervention where they listen to their choice of music genre vs standardized relaxation music during their time in the operating room. Pre and post procedure anxiety questionnaires will be evaluated to rate their experience and anxiety levels during the procedure. | 0 | The Shapiro student will be involved in all aspects of this project. They will be present in clinic and telephone to help recruit patients and perform follow up questionnaires. They will be present on operative days to help obtain patient questionnaires and data gathering. They will be involved with data entry for the project and analysis as well as manuscript preparation. This is a doable project to take from start to completion over the summer. | motivated and independent. | Patient interview, basic statistics, manuscript writing | in process | No | Yes | Yes | Research Electives for credit | Not currently available to mentor other students | No | Katie Schjei Schjei@ortho.wisc.edu research coordinator | No | Music Interventions During Wide-Awake Hand Surgery a Randomized Controlled Trial : Patients who are planned to undergo wide awake (local only anesthetic hand surgery) will be randomized to either a music intervention where they listen to their choice of music genre vs standardized relaxation music during their time in the operating room. Pre and post procedure anxiety questionnaires will be evaluated to rate their experience and anxiety levels during the procedure. ____________________________________________________________________________ Role - The Shapiro student will be involved in all aspects of this project. They will be present in clinic and telephone to help recruit patients and perform follow up questionnaires. They will be present on operative days to help obtain patient questionnaires and data gathering. They will be involved with data entry for the project and analysis as well as manuscript preparation. This is a doable project to take from start to completion over the summer. ; IRB Status - in process; Skills - Patient interview, basic statistics, manuscript writing | Lisa Kruse, kruse@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucPkp2trntDNaxpsiMsvjmdf0ngJ5iumjsSy18hqGaczms46-9oy8hyQ4ZcakgYoEw | |||||||||
| 26/01/2022 | kruse@ortho.wisc.edu | Lisa | kruse | MD | Assistant Professor of Orthopedic Surgery | 608 | Orthopedics and Rehabilitation | Hand Surgery | Effect of Surgeon Clinic Attire on Surgical Conversion Rate in Elective Hand Surgery: A Randomized Controlled Trial. | Surgeons in the hand surgery group will be randomized to either scrubs or dress clothes (suit/dress clothes and white coat) during clinic and conversion rate of elective surgical orders placed during clinic to patients calling to schedule surgery will be compared. | 0 | The student will be responsible for helping with logistical planning for the project, notifying surgeons the day before of their attire for clinic and gathering data during clinic on surgical orders placed and following up on conversion of these orders to scheduled surgeries. This will include data gathering, data entry, statistical evaluation, and manuscript preparation. | Self-motivated able to work independently | Organization, data entry, manuscript preparation | in process | No | Yes | Yes | Research Electives for credit | Not currently available to mentor other students | No | schjei@ortho.wisc.edu Katie Schjei Research Coordinator | No | Effect of Surgeon Clinic Attire on Surgical Conversion Rate in Elective Hand Surgery: A Randomized Controlled Trial. : Surgeons in the hand surgery group will be randomized to either scrubs or dress clothes (suit/dress clothes and white coat) during clinic and conversion rate of elective surgical orders placed during clinic to patients calling to schedule surgery will be compared. ____________________________________________________________________________ Role - The student will be responsible for helping with logistical planning for the project, notifying surgeons the day before of their attire for clinic and gathering data during clinic on surgical orders placed and following up on conversion of these orders to scheduled surgeries. This will include data gathering, data entry, statistical evaluation, and manuscript preparation. ; IRB Status - in process; Skills - Organization, data entry, manuscript preparation | Lisa kruse, kruse@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucFkebXKp3BVrPqh8tabW2AvzZIujUg1Taj8VsGn5-uKu80p-armt0Imdx3415ut-Q | |||||||||
| 31/12/2021 | hlai@wisc.edu | Huichuan | Lai | PhD | Professor of Nutritional Sciences, Pediatrics, and Population Health Sciences | 262 | Other | N/A | Pediatrics | Pulmonology | Emeritus Dean and Professor | pmfarrell@wisc.edu | Pediatrics | Pulmonology | Gut Microbiome Alterations in Young Children with Cystic Fibrosis | This study will test the hypothesis that breastfeeding and dietary supplements such as probiotics and certain medications (particularly chronic antibiotics and acid blockers) alter gut microbiome (GM) of children with cystic fibrosis (CF) compared to their non-CF sibling, and that GM dysbiosis negatively affects nutritional and pulmonary outcomes. The project is an extension of a large investigation of feeding options in young children with CF known as FIRST for (Feeding Infants Right from the Start) that is directed by Professor HuiChuan Lai, Principal Investigator, while Emeritus Dean and Professor Philip Farrell, serves as Co-PI and Professor Michael Rock serves as the site PI for the UW-Madison CF Center/Clinic. The student’s role in the project will begin with literature reviews and tutorial sessions with Dr. Philip Farrell. Then, under the supervision of Professor Lai, the student will organize a large, unique database of fecal microbiome analysis results obtained serially on children with CF for comparison with nutritional and clinical variables. A background and/or aptitude in quantitative research, basic statistical knowledge, and computer skills particularly Microsoft Excel and PowerPoint programs will be important. Opportunities for shadowing in the CF Clinic may become available, although this will depend on the COVID situation. | 1 | The student’s role in the project will begin with literature reviews and tutorial sessions with Dr. Philip Farrell. Then, under the supervision of Professor Lai, the student will organize a large, unique database of fecal microbiome analysis results obtained serially on children with CF for comparison with nutritional and clinical variables. | Semi-independent | A background and/or aptitude in quantitative research, basic statistical knowledge, and computer skills particularly Microsoft Excel and PowerPoint programs will be important. | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Sangita Murali, PhD | Yes | Gut Microbiome Alterations in Young Children with Cystic Fibrosis: This study will test the hypothesis that breastfeeding and dietary supplements such as probiotics and certain medications (particularly chronic antibiotics and acid blockers) alter gut microbiome (GM) of children with cystic fibrosis (CF) compared to their non-CF sibling, and that GM dysbiosis negatively affects nutritional and pulmonary outcomes. The project is an extension of a large investigation of feeding options in young children with CF known as FIRST for (Feeding Infants Right from the Start) that is directed by Professor HuiChuan Lai, Principal Investigator, while Emeritus Dean and Professor Philip Farrell, serves as Co-PI and Professor Michael Rock serves as the site PI for the UW-Madison CF Center/Clinic. The student’s role in the project will begin with literature reviews and tutorial sessions with Dr. Philip Farrell. Then, under the supervision of Professor Lai, the student will organize a large, unique database of fecal microbiome analysis results obtained serially on children with CF for comparison with nutritional and clinical variables. A background and/or aptitude in quantitative research, basic statistical knowledge, and computer skills particularly Microsoft Excel and PowerPoint programs will be important. Opportunities for shadowing in the CF Clinic may become available, although this will depend on the COVID situation. ____________________________________________________________________________ Role - The student’s role in the project will begin with literature reviews and tutorial sessions with Dr. Philip Farrell. Then, under the supervision of Professor Lai, the student will organize a large, unique database of fecal microbiome analysis results obtained serially on children with CF for comparison with nutritional and clinical variables. ; IRB Status - Approved; Skills - A background and/or aptitude in quantitative research, basic statistical knowledge, and computer skills particularly Microsoft Excel and PowerPoint programs will be important. | Huichuan Lai, hlai@wisc.edu -- Co-Mentor: Emeritus Dean and Professor pmfarrell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuflPegpXdXs2C06y4gWwOt5-TRsBEpyfkXU9qdHp0ViJtFetfKqiEFgg7qwTAcr0zM | |||
| 07/12/2021 | dlamming@medicine.wisc.edu | Dudley | Lamming | Ph.D. | Associate Professor | 608 | Medicine | Endocrinology, Diabetes and Metabolism | Associate Professor Dawn Davis, MD, PhD | dbd@medicine.wisc.edu | Medicine | Endocrinology, Diabetes and Metabolism | Improving metabolic health through reduced consumption of specific dietary amino acids | Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ | 0 | The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation. | Medium - students will be co-mentored by Dr. Davis and will be supervised in the clinic by Dr. Rowan Karaman, a VA Advanced Fellow and UW Instructor, but will also work independently. Similarly, students will be trained in any mouse or cell culture work but will be expected to complete experiments independently. Students will analyze data and prepare presentations. | None | Approved | Yes | The Department of Medicine routinely provides this funding for Shapiro students. | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Fontana et al, 2016, Cell Reports, PMID: 27346343; Cummings et al, 2018, J Physiology, PMID: 29266268; additional manuscripts under review | Yes | N/A | Yes | Improving metabolic health through reduced consumption of specific dietary amino acids: Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ ____________________________________________________________________________ Role - The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation.; IRB Status - Approved; Skills - None | Dudley Lamming, dlamming@medicine.wisc.edu -- Co-Mentor: Associate Professor Dawn Davis, MD, PhD dbd@medicine.wisc.edu | |||||
| 10/11/2021 | ftlee@wisc.edu | Fred | Lee | MD | Professor of Radiology | 608 | Radiology | Abdominal Imaging and Intervention | Preparing histotripsy for human clinical use | Histotripsy is a non-invasive, non-thermal, non-ionizing focused ultrasound technology that can destroy targeted tissue through cavitation. Developed at the University of Michigan, our lab at UW is working with both UM and the company (Histosonics, Inc.) to bring the technology closer to human clinical use. This summer, we will be working primarily on targeting histotripsy using non-ultrasound methods such as cone-beam CT and CT/US fusion. | 0 | Work with our lab team to perform animal studies on image-guided histotripsy | Independence for literature reviews, database maintenance, and other non-laboratory work. For animal studies, the student will work with our established research team. | Great work ethic, scientific writing experience, some animal research experience (particularly in large animals) | IACUC approved | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Please see our website. | No | Lab manager is Jim White (jkwhite2@wisc.edu) | No | Preparing histotripsy for human clinical use: Histotripsy is a non-invasive, non-thermal, non-ionizing focused ultrasound technology that can destroy targeted tissue through cavitation. Developed at the University of Michigan, our lab at UW is working with both UM and the company (Histosonics, Inc.) to bring the technology closer to human clinical use. This summer, we will be working primarily on targeting histotripsy using non-ultrasound methods such as cone-beam CT and CT/US fusion. ____________________________________________________________________________ Role - Work with our lab team to perform animal studies on image-guided histotripsy; IRB Status - IACUC approved; Skills - Great work ethic, scientific writing experience, some animal research experience (particularly in large animals) | Fred Lee, ftlee@wisc.edu -- Co-Mentor: | |||||||||
| 08/12/2021 | calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | 6.084.179.953 | Pediatrics | Pediatric Hematology/Oncology | Optimizing care of Adolescents and Young Adults (AYAs) with Cancer | UW started a multidisciplinary telemedicine-based clinic for Adolescents and Young Adults with cancer in January 2021. We are looking for medical students to help analyze data we have collected that could help shape how the clinic improves care for AYAs with cancer, including optimizing transitions of care from pediatric to adult providers as they age out of pediatric practice. | 0 | data analysis, chart review, possibly stakeholder interviews | moderate, will have weekly meetings and plenty of guidance from me | data entry, learn how to review charts in Epic | not yet submitted, project being developed | No | Yes | Yes | Shorter term projects | Not currently available to mentor other students | No | Yes | Department of Pediatrics staff | Yes | Optimizing care of Adolescents and Young Adults (AYAs) with Cancer: UW started a multidisciplinary telemedicine-based clinic for Adolescents and Young Adults with cancer in January 2021. We are looking for medical students to help analyze data we have collected that could help shape how the clinic improves care for AYAs with cancer, including optimizing transitions of care from pediatric to adult providers as they age out of pediatric practice. ____________________________________________________________________________ Role - data analysis, chart review, possibly stakeholder interviews; IRB Status - not yet submitted, project being developed; Skills - data entry, learn how to review charts in Epic | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: | |||||||||
| 08/12/2021 | calee4@wisc.edu | Cathy | Lee-Miller | MD | Assistant Professor of Pediatrics | 6.084.179.953 | Pediatrics | Pediatric Hematology/Oncology | Evaluating best practices in central line maintenance | Central line associated blood stream infections (CLABSIs) are a major source of morbidity and mortality for patients as well as a source of increased patient care costs. This project would focus on utilization of central lines in pediatric patients at AFCH, creating algorithms to help practitioners determine the most appropriate central line for a patient's care and creation of a stewardship program that would alert practitioners when patients they care for could benefit from changing their central line. | 0 | student would familiarize themselves with what CLABSIs are, historical rates at AFCH, types of central lines we use commonly. They would complete chart review and perhaps help create an alert system that keeps track of how long patients have had central lines and what their complication rates are. | student would work cooperatively with me and other learners on this project | data entry, Epic chart review | n/a, will be exempt as it is QI work | No | Yes | Yes | Shorter term projects | Not currently available to mentor other students | No | Yes | n/a | Yes | Evaluating best practices in central line maintenance: Central line associated blood stream infections (CLABSIs) are a major source of morbidity and mortality for patients as well as a source of increased patient care costs. This project would focus on utilization of central lines in pediatric patients at AFCH, creating algorithms to help practitioners determine the most appropriate central line for a patient's care and creation of a stewardship program that would alert practitioners when patients they care for could benefit from changing their central line. ____________________________________________________________________________ Role - student would familiarize themselves with what CLABSIs are, historical rates at AFCH, types of central lines we use commonly. They would complete chart review and perhaps help create an alert system that keeps track of how long patients have had central lines and what their complication rates are.; IRB Status - n/a, will be exempt as it is QI work; Skills - data entry, Epic chart review | Cathy Lee-Miller, calee4@wisc.edu -- Co-Mentor: | |||||||||
| 26/01/2022 | li@ortho.wisc.edu | Wan-Ju | Li | PhD | Associate Professor | Orthopedics and Rehabilitation | Eamon Bernardoni, MD | ebernardoni@uwhealth.org | Orthopedics and Rehabilitation | Fabrication and Evaluation of a “Smart” Cast | Fractures are the most prevalent orthopedic condition, yet current casting practices present frequent complications. Sal-Gel, a recently developed, hybrid material capable of changing from a flexible to a rigid and durable solid possesses characteristics that make it an excellent candidate for casting. This project proposes to investigate the feasibility of Sal-Gel in the cast management of fractures by (1.) evaluating the mechanical properties of various Sal-Gel compositions, (2.) comparing chosen compositions to conventional plaster and fiberglass casting materials, and (3.) comparing cast fabrication techniques (silicone models and rapid liquid 3D printing) to construct 3 different cast designs. We expect that Sal-Gel casts will result in a ready-made, form-fitting, clean, reusable, water-resistant, and easily removable form of extremity immobilization. | 1 | Working in the lab to develop and test different compositions of Sal-Gel materials. Manage data spread sheets with results and assist with dissemination of findings. It is expected that this will work will lead to the development of an abstract for submission to a national scientific meeting and a peer-reviewed manuscript if interested. | Attention to detail. Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. General wet laboratory skills and biochemistry background is appreciated, although data collection and mechanical techniques will be taught through supervised learning during study data collections. | N/A | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Ableidinger@ortho.wisc.edu, Kuhn@ortho.wisc.edu | No | Fabrication and Evaluation of a “Smart” Cast: Fractures are the most prevalent orthopedic condition, yet current casting practices present frequent complications. Sal-Gel, a recently developed, hybrid material capable of changing from a flexible to a rigid and durable solid possesses characteristics that make it an excellent candidate for casting. This project proposes to investigate the feasibility of Sal-Gel in the cast management of fractures by (1.) evaluating the mechanical properties of various Sal-Gel compositions, (2.) comparing chosen compositions to conventional plaster and fiberglass casting materials, and (3.) comparing cast fabrication techniques (silicone models and rapid liquid 3D printing) to construct 3 different cast designs. We expect that Sal-Gel casts will result in a ready-made, form-fitting, clean, reusable, water-resistant, and easily removable form of extremity immobilization. ____________________________________________________________________________ Role - Working in the lab to develop and test different compositions of Sal-Gel materials. Manage data spread sheets with results and assist with dissemination of findings. It is expected that this will work will lead to the development of an abstract for submission to a national scientific meeting and a peer-reviewed manuscript if interested.; IRB Status - N/A; Skills - Attention to detail. Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. General wet laboratory skills and biochemistry background is appreciated, although data collection and mechanical techniques will be taught through supervised learning during study data collections. | Wan-Ju Li, li@ortho.wisc.edu -- Co-Mentor: Eamon Bernardoni, MD ebernardoni@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufing0tlO7PfWvQpudMhPxFnLbo4ce8jT9B4OP0eMZqGdHGM3w9GWM_EKywBKIarVg | |||||||||
| 13/01/2022 | mtlong@wisc.edu | Micah | Long | MD | Assistant Professor | 920 | Anesthesiology | Critical Care Anesthesiology | John Dollerschell, MD, Assistant Professor | dollerschell@wisc.edu | Anesthesiology | Critical Care and Cardiac Anesthesiology | Code Outcomes with a Dedicated Nursing Code Team | Nationally, in-hospital cardiac arrest carries a dismal prognosis, with nearly a 35% mortality rate, with many survivors suffering from significant morbidity. Our hospital transitioned from an "all-call" nursing team who arrived at codes, to a specific nursing team that helped to direct and participate in compressions, complete laboratory work, assist with line placement and to help complete other tasks (e.g. CPR board placement, intraosseus access placement). Preliminary data suggest improved return of spontaneous circulation (ROSC) in the arrest and improved mortality afterwards with the institution of the dedicated nursing code team. The Shapiro student will collect full code data and patient outcomes for patients who suffered from in-hospital arrest before and after the team's institution. We will stratify this data by age, expected patient mortality, duration of compressions and the like. | 0 | Data Collection | Independent data collection is expected. We will mentor through this research project and clinical and other research experiences as the student deems useful for their career development. | None | In submission for retrospective review exemption | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | N/A | No | Code Outcomes with a Dedicated Nursing Code Team: Nationally, in-hospital cardiac arrest carries a dismal prognosis, with nearly a 35% mortality rate, with many survivors suffering from significant morbidity. Our hospital transitioned from an "all-call" nursing team who arrived at codes, to a specific nursing team that helped to direct and participate in compressions, complete laboratory work, assist with line placement and to help complete other tasks (e.g. CPR board placement, intraosseus access placement). Preliminary data suggest improved return of spontaneous circulation (ROSC) in the arrest and improved mortality afterwards with the institution of the dedicated nursing code team. The Shapiro student will collect full code data and patient outcomes for patients who suffered from in-hospital arrest before and after the team's institution. We will stratify this data by age, expected patient mortality, duration of compressions and the like. ____________________________________________________________________________ Role - Data Collection; IRB Status - In submission for retrospective review exemption; Skills - None | Micah Long, mtlong@wisc.edu -- Co-Mentor: John Dollerschell, MD, Assistant Professor dollerschell@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueOXJHBnHRf45CcEfOrBp6hvSInI-a_WQ4Cvp4UiWcZ79dFpXXc7Ld_YcN9AS_QTZo | |||||
| 23/12/2021 | mlubner@uwhealth.org | Meghan | Lubner | MD | Professor | 6.082.639.028 | Radiology | Abdominal Imaging and Intervention | Perry Pickhardt | ppickhardt2@uwhealth.org | Radiology | Abdominal Imaging and Intervention | Multiple abdominal radiology projects | 1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones, liver, spleen. Possible renal stone volume project now. 2. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series 3. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques (DLIR), ex impact of use of oral contrast in ED, oral contrast and visceral fat (using AI tool), consequences of changing kV and impact on HU measurements. Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, stercoral colitis series, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc 4. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 6. CT colonography related projects 7. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 8. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc | 2 | Project lead | Moderate | Basic excel, word, ppt, knowledge of R a bonus | approved | No | Radiology R/D has helped cover in past | Yes | Research Electives for credit | Not currently available to mentor other students | Sampling of prior Shapiro publications: Bannas, P., Bakke, J., Patrick, J. L., & Pickhardt, P. J. (2015). Automated volumetric analysis for comparison of oral sulfate solution (SUPREP) with established cathartic agents at CT colonography (vol 40, pg 11, 2015). Abdominal Imaging, 40(6), 2066-2066. doi:10.1007/s00261-015-0415-y Elissa, M., Lubner, M. G., & Pickhardt, P. J. (2019). Biopsy of Deep Pelvic and Abdominal Targets With Ultrasound Guidance: Efficacy of Compression. AJR Am J Roentgenol, 1-6. doi:10.2214/AJR.19.21104 Hunt, O. M. F., Lubner, M. G., Ziemlewicz, T. J., del Rio, A. M., & Pickhardt, P. J. (2016). The Liver Segmental Volume Ratio for Noninvasive Detection of Cirrhosis: Comparison With Established Linear and Volumetric Measures. Journal of Computer Assisted Tomography, 40(3), 478-484. doi:10.1097/Rct.0000000000000389 Kim, N. Y., Lubner, M. G., Nystrom, J. T., Swietlik, J. F., Abel, E. J., Havighurst, T. C., . . . Pickhardt, P. J. (2019). Utility of CT Texture Analysis in Differentiating Low-Attenuation Renal Cell Carcinoma From Cysts: A Bi-Institutional Retrospective Study. AJR Am J Roentgenol, 213(6), 1259-1266. doi:10.2214/AJR.19.21182 Lee, S. J., Binkley, N., Lubner, M. G., Bruce, R. J., Ziemlewicz, T. J., & Pickhardt, P. J. (2016). Opportunistic screening for osteoporosis using the sagittal reconstruction from routine abdominal CT for combined assessment of vertebral fractures and density. Osteoporos Int, 27(3), 1131-1136. doi:10.1007/s00198-015-3318-4 Lubner, M. G., Malecki, K., Kloke, J., Ganeshan, B., & Pickhardt, P. J. (2017). Texture analysis of the liver at MDCT for assessing hepatic fibrosis. Abdom Radiol (NY), 42(8), 2069-2078. doi:10.1007/s00261-017-1096-5 Lubner, M. G., Stabo, N., Abel, E. J., del Rio, A. M., & Pickhardt, P. J. (2016). CT Textural Analysis of Large Primary Renal Cell Carcinomas: Pretreatment Tumor Heterogeneity Correlates With Histologic Findings and Clinical Outcomes. American Journal of Roentgenology, 207(1), 96-105. doi:10.2214/Ajr.15.15451 Lubner, M. G., Stabo, N., Lubner, S. J., del Rio, A. M., Song, C., Halberg, R. B., & Pickhardt, P. J. (2015). CT textural analysis of hepatic metastatic colorectal cancer: pre-treatment tumor heterogeneity correlates with pathology and clinical outcomes. Abdom Imaging, 40(7), 2331-2337. doi:10.1007/s00261-015-0438-4 Lubner, M. G., Stabo, N., Lubner, S. J., Del Rio, A. M., Song, C., & Pickhardt, P. J. (2017). Volumetric Versus Unidimensional Measures of Metastatic Colorectal Cancer in Assessing Disease Response. Clin Colorectal Cancer, 16(4), 324-333 e321. doi:10.1016/j.clcc.2017.03.009 Patrick, J. L., Bakke, J. R., Bannas, P., Kim, D. H., Lubner, M. G., & Pickhardt, P. J. (2015). Objective volumetric comparison of room air versus carbon dioxide for colonic distention at screening CT colonography. Abdominal Imaging, 40(2), 231-236. doi:10.1007/s00261-014-0206-x Pickhardt, P. J., Bakke, J., Kuo, J., Robbins, J. B., Lubner, M. G., del Rio, A. M., & Kim, D. H. (2014). Volumetric Analysis of Colonic Distention According to Patient Position at CT Colonography: Diagnostic Value of the Right Lateral Decubitus Series. American Journal of Roentgenology, 203(6), W623-W628. doi:10.2214/Ajr.13.12369 Pickhardt, P. J., Malecki, K., Hunt, O. F., Beaumont, C., Kloke, J., Ziemlewicz, T. J., & Lubner, M. G. (2017). Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis. Eur Radiol, 27(7), 3060-3068. doi:10.1007/s00330-016-4648-0 Pickhardt, P. J., Malecki, K., Kloke, J., & Lubner, M. G. (2016). Accuracy of Liver Surface Nodularity Quantification on MDCT as a Noninvasive Biomarker for Staging Hepatic Fibrosis. AJR Am J Roentgenol, 207(6), 1194-1199. doi:10.2214/ajr.16.16514 Scrima, A., Lubner, M. G., King, S., Kennedy, G., & Pickhardt, P. J. (2017). Abdominal Multidetector Computed Tomography for Suspected Small-Bowel Obstruction: Multireader Study Comparing Radiologist Performance for Predicting Surgical Outcomes. Journal of Computer Assisted Tomography, 41(3), 388-393. doi:10.1097/Rct.0000000000000529 Scrima, A., Lubner, M. G., King, S., Pankratz, J., Kennedy, G., & Pickhardt, P. J. (2017). Value of MDCT and Clinical and Laboratory Data for Predicting the Need for Surgical Intervention in Suspected Small-Bowel Obstruction. American Journal of Roentgenology, 208(4), 785-793. doi:10.2214/Ajr.16.16946 Scrima, A. T., Lubner, M. G., Abel, E. J., Havighurst, T. C., Shapiro, D. D., Huang, W., & Pickhardt, P. J. (2019). Texture analysis of small renal cell carcinomas at MDCT for predicting relevant histologic and protein biomarkers. Abdominal Radiology, 44(6), 1999-2008. doi:10.1007/s00261-018-1649-2 | No | Lorene Seman | Multiple abdominal radiology projects: 1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones, liver, spleen. Possible renal stone volume project now. 2. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series 3. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques (DLIR), ex impact of use of oral contrast in ED, oral contrast and visceral fat (using AI tool), consequences of changing kV and impact on HU measurements. Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, stercoral colitis series, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc 4. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 6. CT colonography related projects 7. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 8. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc ____________________________________________________________________________ Role - Project lead; IRB Status - approved; Skills - Basic excel, word, ppt, knowledge of R a bonus | Meghan Lubner, mlubner@uwhealth.org -- Co-Mentor: Perry Pickhardt ppickhardt2@uwhealth.org | ||||||
| 18/12/2021 | vtma@medicine.wisc.edu | Vincent | Ma | MD | Assistant Professor (CHS) | Medicine | Hematology, Medical Oncology, and Palliative Care | Oncology | Clinical Outcomes of Metastatic Melanoma and Other Advanced Cutaneous Malignancies | I am creating a database of melanoma and non-melanoma skin cancer patients who were treated with chemotherapy, immunotherapy, and targeted therapy at the University of Wisconsin with the intended goal of understanding factors that contribute to treatment resistance and poor survival outcomes in this population. Using this database, we plan to conduct multivariable statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports, and present high-impact results at international conferences. | 0 | Chart review; working with a statistician; and writing articles for publication and abstract presentations. | Students will require some training on data extraction from HealthLink (UW's electronic medical records system) and education about oncology therapies, but will otherwise be independent with chart reviewing on their own time. Very flexible hours. | None. Just willingness to be motivated and patient with chart reviewing patients. | IRB Exempt (UW21110) | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | No | N/A | No | Clinical Outcomes of Metastatic Melanoma and Other Advanced Cutaneous Malignancies: I am creating a database of melanoma and non-melanoma skin cancer patients who were treated with chemotherapy, immunotherapy, and targeted therapy at the University of Wisconsin with the intended goal of understanding factors that contribute to treatment resistance and poor survival outcomes in this population. Using this database, we plan to conduct multivariable statistical analyses of relevant findings to publish original studies, review articles, case series, and case reports, and present high-impact results at international conferences. ____________________________________________________________________________ Role - Chart review; working with a statistician; and writing articles for publication and abstract presentations.; IRB Status - IRB Exempt (UW21110); Skills - None. Just willingness to be motivated and patient with chart reviewing patients. | Vincent Ma, vtma@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud-48CxhYKdVlQmsntnxVcUQ8lvgAA-rJHd9zVP-dSmk7qL-8zZF88ZErtqz7tescM | |||||||||
| 02/12/2021 | ammarsh@wisc.edu | Anne | Marsh | MD | Associate Professor of Pediatrics | 608 | Pediatrics | Pediatric Hematology-Oncology | Transcranial Doppler Ultrasound as a Quality Measure in Pediatric Sickle Cell Disease | The objective of this project is to evaluate our institutional adherence to annual transcranial Doppler ultrasound (TCD) screening recommendations for pediatric patients with sickle cell anemia (SCA). TCD is used as a screening tool to help identify which children with SCA fall into a higher risk category for developing a stroke. In the Stroke Prevention Trial in Sickle Cell Anemia, published in 1998, children at high risk of stroke who were started on chronic red blood cell transfusions had a 92% reduction in the incidence of first stroke. It therefore became standard of care to screen children using TCD and when indicated, start chronic transfusion therapy for primary stroke prevention. Preliminary anecdotal review of our institutional data suggests we are not meeting this evidence-based standard of care. | 0 | The student will be responsible for a conducting a chart review of our ~60 patients with sickle cell disease to determine our TCD performance rate. The student will be responsible for conducting a EMR-based chart review to capture data to answer the following question: Performance Rate Calculation Identify the denominator: Determine the eligible population. The eligible population is all individuals who satisfy age and sickle cell genotype criteria. Identify the numerator: Documented completion of a TCD during an eligible time period. Calculate the rate (numerator / denominator). This baseline data will then likely be used to develop a QI project aimed to improve our adherence to this important quality measure (this may or may not be part of the summer project). | High | Basic knowledge of how to use an Excel database | N/A | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students, Shorter term projects | Not currently available to mentor other students | Pediatr Qual Saf. 2020 Dec 28;6(1):e379. doi: 10.1097/pq9.0000000000000379. | No | N/A | No | Transcranial Doppler Ultrasound as a Quality Measure in Pediatric Sickle Cell Disease: The objective of this project is to evaluate our institutional adherence to annual transcranial Doppler ultrasound (TCD) screening recommendations for pediatric patients with sickle cell anemia (SCA). TCD is used as a screening tool to help identify which children with SCA fall into a higher risk category for developing a stroke. In the Stroke Prevention Trial in Sickle Cell Anemia, published in 1998, children at high risk of stroke who were started on chronic red blood cell transfusions had a 92% reduction in the incidence of first stroke. It therefore became standard of care to screen children using TCD and when indicated, start chronic transfusion therapy for primary stroke prevention. Preliminary anecdotal review of our institutional data suggests we are not meeting this evidence-based standard of care. ____________________________________________________________________________ Role - The student will be responsible for a conducting a chart review of our ~60 patients with sickle cell disease to determine our TCD performance rate. The student will be responsible for conducting a EMR-based chart review to capture data to answer the following question: Performance Rate Calculation Identify the denominator: Determine the eligible population. The eligible population is all individuals who satisfy age and sickle cell genotype criteria. Identify the numerator: Documented completion of a TCD during an eligible time period. Calculate the rate (numerator / denominator). This baseline data will then likely be used to develop a QI project aimed to improve our adherence to this important quality measure (this may or may not be part of the summer project). ; IRB Status - N/A; Skills - Basic knowledge of how to use an Excel database | Anne Marsh, ammarsh@wisc.edu -- Co-Mentor: | |||||||||
| 15/12/2021 | kmarten@uwhealth.org | Kristen | Marten | DO | Dr. | 608 | Pediatrics | General Pediatrics and Adolescent Medicine | Pediatrics | Pediatric Cardiology | Bradley Kerr | bkerr@wisc.edu | Pediatrics | Parental Opinions on Pediatric Obesity: A Qualitative Study | We are performing interviews with parents of children with obesity to better determine their perspectives regarding their child's healthy habits and any barriers in maintaining healthy habits. Shapiro students would be responsible for helping with developing a codebook based on interviews, identifying themes, and writing the final manuscript. | 0 | Development of codebook, identifying themes, and drafting of manuscript | None | IRB exemption | Yes | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Megan Moreno, moreno@wisc.edu | No | Parental Opinions on Pediatric Obesity: A Qualitative Study : We are performing interviews with parents of children with obesity to better determine their perspectives regarding their child's healthy habits and any barriers in maintaining healthy habits. Shapiro students would be responsible for helping with developing a codebook based on interviews, identifying themes, and writing the final manuscript. ____________________________________________________________________________ Role - Development of codebook, identifying themes, and drafting of manuscript ; IRB Status - IRB exemption ; Skills - None | Kristen Marten, kmarten@uwhealth.org -- Co-Mentor: Bradley Kerr bkerr@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucQ30Uh41kGyrxIRWnPNPvKTm2Cz4zDWoq39O9mSBa1qGeqXHpy71mep57haOc40sM | |||||
| 05/01/2022 | Jomol.Mathew@wisc.edu | Jomol | Mathew | PhD | Associate Dean for Informatics and Information Technology | Population Health Sciences | Saiju Pyarajan, PhD, Associate Professor | Pyarajan@wisc.edu | Medicine | The UW Molecular Biomarker Database | The project is focussed on developing the UW Molecular Biomarker Database. It aims to catalogue all the clinical genomic tests and patient level test results from the Electronic Health record. Currently many of the clinical genomic test results are scanned into EHR manually. Cataloguing the tests and abstracting relevant results will enable phenome-genome association studies and generate data driven insights and new questions. We are inviting students to participate in this informatics initiative and learn informatics techniques involved in the generation and use of the biomarker database for research studies. | 2 | The students will be involved in planning, design and development of the database; abstraction of data from the EHR which might involve NLP, standardization and annotation of the markers. | While the project will provide an opportunity to learn informatics concepts, experience in databases or molecular biology preferred. | Application for IRB exemption to be submitted | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | Unsure / Depends | Laura Ladick ladick@wisc.edu | No | The UW Molecular Biomarker Database: The project is focussed on developing the UW Molecular Biomarker Database. It aims to catalogue all the clinical genomic tests and patient level test results from the Electronic Health record. Currently many of the clinical genomic test results are scanned into EHR manually. Cataloguing the tests and abstracting relevant results will enable phenome-genome association studies and generate data driven insights and new questions. We are inviting students to participate in this informatics initiative and learn informatics techniques involved in the generation and use of the biomarker database for research studies. ____________________________________________________________________________ Role - The students will be involved in planning, design and development of the database; abstraction of data from the EHR which might involve NLP, standardization and annotation of the markers. ; IRB Status - Application for IRB exemption to be submitted; Skills - While the project will provide an opportunity to learn informatics concepts, experience in databases or molecular biology preferred. | Jomol Mathew, Jomol.Mathew@wisc.edu -- Co-Mentor: Saiju Pyarajan, PhD, Associate Professor Pyarajan@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf8uQ6E4RxAcTO1d2UNj38vV7VEsCZjmtgLP0XoisKmQxGOj6JXX9q-T9V5dOIHXKw | |||||||||
| 05/01/2022 | mmathur@wisc.edu | Mala | Mathur | MD, MPH | Associate Professor of Pediatrics | 0 | Pediatrics | General Pediatrics and Adolescent Medicine | Brad Kerr | bkerr@wisc.edu | Pediatrics | General Pediatrics and Adolescent Medicine | Pediatric Integrative Health Research Team | Mindfulness practices may be beneficial for parents and children to promote wellness, reduce stress, improve relational health and impact mental and physical health outcomes. In working with the Department of Pediatrics Integrative Health Research Team, you will have an opportunity to explore different research methodologies and contribute to a project that addresses the overall health of children and families. Some of our past projects have focused on ways to understand the perspective of parents in learning about Mindfulness practices. Current and future projects may include a content analysis project examining the availability of Mindfulness websites and apps for parents and children, the evaluation of a Parenting/Caregiver Mindfulness Retreat and its effects on the relational health between parents/caregivers and their children and other projects. | 1 | Students may choose to be involved in idea generation, study design, data collection and analysis and writing up this work by developing an abstract for submission to local and/or national conferences. In the past, some Shapiro students have chosen to write up their work as a manuscript for submission to a journal. | Moderate | Ability to work on a team, and an interest in learning about integrative health and research methodologies. | IRB has been obtained for some of our projects | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Yes | Christine Richards (crichards9@wisc.edu) and Kim Stevenson (kdstevenson@pediatrics.wisc.edu) | Yes | Pediatric Integrative Health Research Team: Mindfulness practices may be beneficial for parents and children to promote wellness, reduce stress, improve relational health and impact mental and physical health outcomes. In working with the Department of Pediatrics Integrative Health Research Team, you will have an opportunity to explore different research methodologies and contribute to a project that addresses the overall health of children and families. Some of our past projects have focused on ways to understand the perspective of parents in learning about Mindfulness practices. Current and future projects may include a content analysis project examining the availability of Mindfulness websites and apps for parents and children, the evaluation of a Parenting/Caregiver Mindfulness Retreat and its effects on the relational health between parents/caregivers and their children and other projects. ____________________________________________________________________________ Role - Students may choose to be involved in idea generation, study design, data collection and analysis and writing up this work by developing an abstract for submission to local and/or national conferences. In the past, some Shapiro students have chosen to write up their work as a manuscript for submission to a journal.; IRB Status - IRB has been obtained for some of our projects; Skills - Ability to work on a team, and an interest in learning about integrative health and research methodologies. | Mala Mathur, mmathur@wisc.edu -- Co-Mentor: Brad Kerr bkerr@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucGzb-2CZk5ag8ByLp1TcX6R4YTRgSY-sMUNvHVcxpe6kTYEnzHX9n18RFPQrY3j-U | ||||
| 24/01/2022 | smcgregor@wisc.edu | Stephanie | McGregor | MD PhD | Assistant Professor | 6.082.639.468 | Pathology and Laboratory Medicine | Biomarkers in endometrial cancer | Endometrial carcinoma (EC) is a highly heterogeneous disease with multiple histologic types that are associated with differing clinical outcomes. These differences in biological behavior are actually better correlated with molecular findings than with histomorphology. However, despite substantial interobserver disagreement, histologic classification remains a mainstay of clinical decision-making. Historically, distinguishing between the various types of high-grade tumors, such as serous carcinoma (SC) and clear cell carcinoma (CCC), has been largely academic due to shared treatment approaches. But now with use of HER2-based therapy in SC but not for other types of high-grade EC, a diagnosis of CCC in serous-like tumors has the potential to exclude patients from receiving beneficial therapy. We have previously demonstrated that HER2 is expressed in the majority of EC diagnosed as CCC and that these tumors demonstrate either aberrant p53 or absence of ER expression as well as extensive morphologic overlap with SC. We plan to expand our cohort and address HER2 in cases diagnosed as CCC more broadly and to assess the possibility that p53 and ER as a panel may enable us to reclassify cases currently regarded as CCC in a more clinically meaningful way. This will be performed by immunohistochemical staining for a variety of markers on unstained slides provided by collaborators throughout the country. (Note: There are additional opportunities for contributing to other ongoing projects as well.) | 0 | Assessing immunohistochemical stains and analyzing expression patterns according to tumor morphology, correlating findings with clinical outcomes | Student would work largely independently but would have immediate access to PI for questions as needed and regularly scheduled meetings for guidance/mentorship throughout the length of the program | Excel, attention to detail; experience with microscopy and/or medical statistics would be a plus but not required | Approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Not currently available to mentor other students | No | Rachel Kulow, ragrimm@wisc.edu | No | Biomarkers in endometrial cancer: Endometrial carcinoma (EC) is a highly heterogeneous disease with multiple histologic types that are associated with differing clinical outcomes. These differences in biological behavior are actually better correlated with molecular findings than with histomorphology. However, despite substantial interobserver disagreement, histologic classification remains a mainstay of clinical decision-making. Historically, distinguishing between the various types of high-grade tumors, such as serous carcinoma (SC) and clear cell carcinoma (CCC), has been largely academic due to shared treatment approaches. But now with use of HER2-based therapy in SC but not for other types of high-grade EC, a diagnosis of CCC in serous-like tumors has the potential to exclude patients from receiving beneficial therapy. We have previously demonstrated that HER2 is expressed in the majority of EC diagnosed as CCC and that these tumors demonstrate either aberrant p53 or absence of ER expression as well as extensive morphologic overlap with SC. We plan to expand our cohort and address HER2 in cases diagnosed as CCC more broadly and to assess the possibility that p53 and ER as a panel may enable us to reclassify cases currently regarded as CCC in a more clinically meaningful way. This will be performed by immunohistochemical staining for a variety of markers on unstained slides provided by collaborators throughout the country. (Note: There are additional opportunities for contributing to other ongoing projects as well.) ____________________________________________________________________________ Role - Assessing immunohistochemical stains and analyzing expression patterns according to tumor morphology, correlating findings with clinical outcomes ; IRB Status - Approved; Skills - Excel, attention to detail; experience with microscopy and/or medical statistics would be a plus but not required | Stephanie McGregor, smcgregor@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucHsTle8p2IHx5utiJq6LTa88lPf23f3sFD9r3YNZkG7WbHkO9rjLPmabckuReecEU | ||||||||||
| 07/12/2021 | McGuine@ortho.wisc.edu | Tim | McGuine | PhD | Distinguished Scientist | 608 | Orthopedics and Rehabilitation | Sports Medicine | Pamela Lang MD | PLang@ortho.wisc.edu | Orthopedics and Rehabilitation | UW Orthopedics Youth Knee Injury Registry | The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. | 0 | 1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production | Moderate | Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents | HS-IRB 2019-0028 - Approved | No | Yes | Yes | Shorter term projects, Research Electives for credit | DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | McGuine TA, Pfaller A, Kliethermes S, Schwarz A, Hetzel S, Hammer E, Broglio S. The effect of sport-related concussion injuries on concussion symptoms and health-related quality of life in male and female adolescent athletes: a prospective study. Am J Sports Med. 2019;47(14):3514–3520 DOI: 10.1177/0363546519880175 Kijowski R, Thurlow P, Blankenbaker D, Liu F, McGuine TA, Li G, Tuite M. Preoperative MRI Shoulder Findings Associated with Clinical Outcome 1 Year after Rotator Cuff Repair. Radiology. 2019 Apr 23;291(3):722-9. McGuine TA, Post EG, Hetzel, S, Pfallar A, Brooks MA, Bell D. A Prospective Study on the Impact of Sport Specialization on Lower Extremity Injury Rates in High School Athletes. American Journal of Sports Medicine. doi.org/10.1177/0363546517710213 McGuine TA, Hetzel S, Carr K, Winterstein A. Changes in Health-Related Quality of Life and Knee Function After Knee Injury in Young Female Athletes." Orthopedic Journal of Sports Medicine. 2.4 2014: DOI: 2325967114530988. Winterstein A, McGuine TA, Hetzel S, Carr K. Changes in Self-reported Physical Activity Following Knee Injury in Active Females. Athletic Training and Sports Health Care. 2013 5(3):106-114. McGuine TA, Hetzel S, Pennuto T, Brooks MA. Basketball Coaches' Utilization of Ankle Injury Prevention Strategies Sports Health: A Multidisciplinary Approach 2013;5(5):410-416. McGuine TA, Winterstein A, Carr K, Hetzel S, Scott J. Changes in Self-Reported Knee Function and Health-Related Quality of Life After Knee Injury in Female Athletes. Clinical Journal of Sports Medicine 2012; 22(4):334-340. Kijowski R, Sanago M, Lee K, Munoz del Rio A, McGuine TA, Baer G, Graf BK, De Smet AA. Short-term Clinical Importance of Osseous Injuries Diagnosed at MR Imaging in Patients with Anterior Cruciate Ligament Tear. Radiology. 2012; 264 (2): 531-541. Kijowski R, Woods MA, McGuine TA, Wilson JJ, Graf BK, De Smet AA. Arthroscopic partial meniscectomy: MR imaging for prediction of outcome in middle-aged and elderly patients. Radiology. 2011: 259(1);203-212. | Yes | Heidi Ableidinger (Ableidinger@ortho.wisc.edu); Emily Kay Koresh (ekoresh@wisc.edu); Liana Nash (Nash@ortho.wisc.edu) | Yes | UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. ____________________________________________________________________________ Role - 1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production; IRB Status - HS-IRB 2019-0028 - Approved; Skills - Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents | Tim McGuine, McGuine@ortho.wisc.edu -- Co-Mentor: Pamela Lang MD PLang@ortho.wisc.edu | ||||||
| 16/12/2021 | mezrich@surgery.wisc.edu | Josh | Mezrich | MD | Professor | 16.088.526.298 | Surgery | Transplant | Characterization of the Intestinal Microbiome and Circulating Bacterial DNA in the Deceased Organ Donor | We will characterize the changes in composition of the intestinal microbiome after brain death declaration; quantify levels of circulating microbial DNA in plasma samples from BD donors over time and assess the systemic inflammatory response in the serum, cellular and tissue level; and evaluate the correlation microbial dysbiosis, bacterial translocation and inflammatory status of the BD donor and functional outcomes of transplanted organs | 1 | Will perform assays using flow cytometry, cell culture, stool transplants, analyze data | medium | enthusiasm | Will be working on it now in anticipation of summer | external funding | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | PhD students, UW undergraduates interested in research | No | John Fechner | No | Characterization of the Intestinal Microbiome and Circulating Bacterial DNA in the Deceased Organ Donor: We will characterize the changes in composition of the intestinal microbiome after brain death declaration; quantify levels of circulating microbial DNA in plasma samples from BD donors over time and assess the systemic inflammatory response in the serum, cellular and tissue level; and evaluate the correlation microbial dysbiosis, bacterial translocation and inflammatory status of the BD donor and functional outcomes of transplanted organs ____________________________________________________________________________ Role - Will perform assays using flow cytometry, cell culture, stool transplants, analyze data; IRB Status - Will be working on it now in anticipation of summer; Skills - enthusiasm | Josh Mezrich, mezrich@surgery.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufcx0HX0doN5hX_qhUI98_aJW7f72XLYMOBr0jch2mDGqF3eEBsUKvacjUfvjd2WHA | |||||||||
| 17/01/2022 | ctmichels@medicine.wisc.edu | Collin | Michels | MD | Clinical Instructor Department of Emergency Medicine | 6.056.611.759 | Emergency Medicine | Elizabeth Salisbury-Afshar, MD, MPH | elizabeth.salisbury-afshar@fammed.wisc.edu | Family Medicine and Community Health | Investigating Emergency Department Clinician Views on Naloxone Dispensing and Initiation of Medications for Opioid Use Disorder | The overall objective of this work is to support UWH ED in implementation of best practices related to naloxone distribution and buprenorphine initiation in the ED with linkage to ongoing continuity buprenorphine treatment. As a first step in achieving this objective, we will survey UWH emergency medicine clinicians, nurses, and social workers to improve our understanding of existing knowledge gaps, concerns related to naloxone distribution and buprenorphine initiation in the ED, and perceived barriers to the delivery of these services. Providers, nurses, and social workers interact with patients in the ED in different and meaningful ways. Nursing staff provides the first line of care from the triage process to the discharge process. Social workers are involved with patients who report unhealthy substance use. Providers are assessing, diagnosing, and treating the patients in the ED but may interact with the patients less than nurses and social workers. As a result, it is critical that we understand the knowledge, attitudes, beliefs, and perceived barriers of each of these groups. We hypothesize that those who completed training within the last 5 years as well as those who trained in the Northeast or West Coast (where these innovative practices were researched and scaled), will be more comfortable with the concept of naloxone distribution and buprenorphine initiation in the ED. The goals of the project are to: - Assess knowledge, attitudes, beliefs and perceived barriers of UWH ED clinicians, RNs, and Social Workers related to naloxone distribution in the ED. - Assess knowledge, attitudes, beliefs and perceived barriers of UWH ED clinicians, RNs, and Social Workers related to buprenorphine treatment initiation in the ED. - Analyze and report the survey data collected to inform future educational interventions that will improve the care of individuals with opioid use disorder seen/treated in the UWH ED. This information collected from the surveys will subsequently be used to inform the development of educational and workflow interventions that will be part of broader UWH ED efforts to improve the quality of opioid overdose and opioid use disorder-related care delivered. By understanding the current attitudes, beliefs, and perceived barriers to naloxone distribution and buprenorphine initiation in the ED we can develop strategic interventions to improve care for patients with opioid use disorder. We anticipate that forthcoming interventions in the ED would rely heavily on nursing staff as the first line of care for the patients. We believe these results can inform future interventions that can have benefits outside of the UW Health system and serve as a model for other facilities in Dane County and in Wisconsin. | 0 | The student will be involved in a literature review, survey collection, data entry, and data analysis as well as abstract and manuscript writing. Other possible opportunities include clinical shadowing in the emergency department and/or the addiction medicine clinic along with other substance use-related community experiences. | n/a | Not yet submitted but will in the next few months | Department of Family Medicine and Community Health 'Small Grant' | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | Unsure / Depends | Dr Manish Shah, Vice Chair of Research Department of Emergency Medicine. mnshaw@medicine.wisc.edu. Jessie Libber, Research Manager Department of Emergency Medicine. jslibber@medicine.wisc.edu | Yes | Investigating Emergency Department Clinician Views on Naloxone Dispensing and Initiation of Medications for Opioid Use Disorder: The overall objective of this work is to support UWH ED in implementation of best practices related to naloxone distribution and buprenorphine initiation in the ED with linkage to ongoing continuity buprenorphine treatment. As a first step in achieving this objective, we will survey UWH emergency medicine clinicians, nurses, and social workers to improve our understanding of existing knowledge gaps, concerns related to naloxone distribution and buprenorphine initiation in the ED, and perceived barriers to the delivery of these services. Providers, nurses, and social workers interact with patients in the ED in different and meaningful ways. Nursing staff provides the first line of care from the triage process to the discharge process. Social workers are involved with patients who report unhealthy substance use. Providers are assessing, diagnosing, and treating the patients in the ED but may interact with the patients less than nurses and social workers. As a result, it is critical that we understand the knowledge, attitudes, beliefs, and perceived barriers of each of these groups. We hypothesize that those who completed training within the last 5 years as well as those who trained in the Northeast or West Coast (where these innovative practices were researched and scaled), will be more comfortable with the concept of naloxone distribution and buprenorphine initiation in the ED. The goals of the project are to: - Assess knowledge, attitudes, beliefs and perceived barriers of UWH ED clinicians, RNs, and Social Workers related to naloxone distribution in the ED. - Assess knowledge, attitudes, beliefs and perceived barriers of UWH ED clinicians, RNs, and Social Workers related to buprenorphine treatment initiation in the ED. - Analyze and report the survey data collected to inform future educational interventions that will improve the care of individuals with opioid use disorder seen/treated in the UWH ED. This information collected from the surveys will subsequently be used to inform the development of educational and workflow interventions that will be part of broader UWH ED efforts to improve the quality of opioid overdose and opioid use disorder-related care delivered. By understanding the current attitudes, beliefs, and perceived barriers to naloxone distribution and buprenorphine initiation in the ED we can develop strategic interventions to improve care for patients with opioid use disorder. We anticipate that forthcoming interventions in the ED would rely heavily on nursing staff as the first line of care for the patients. We believe these results can inform future interventions that can have benefits outside of the UW Health system and serve as a model for other facilities in Dane County and in Wisconsin. ____________________________________________________________________________ Role - The student will be involved in a literature review, survey collection, data entry, and data analysis as well as abstract and manuscript writing. Other possible opportunities include clinical shadowing in the emergency department and/or the addiction medicine clinic along with other substance use-related community experiences.; IRB Status - Not yet submitted but will in the next few months ; Skills - n/a | Collin Michels, ctmichels@medicine.wisc.edu -- Co-Mentor: Elizabeth Salisbury-Afshar, MD, MPH elizabeth.salisbury-afshar@fammed.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuczFAiMUhKOeHkxLWD1WWgKzEWwEz3JYis0V9iiiC7QU9OGPC8xl2kezibgwDw9PMU | ||||||||
| 23/02/2022 | kmiller5@uwmf.wisc.edu | Katie | Miller | MD | Assistant Professor | 2.062.761.272 | Medicine | General Internal Medicine | Patient and Clinical Outcomes from an Osteoarthritis Management Program | Osteoarthritis is a common disease that is can be difficult to treat. To address these barriers, new models of care are being proposed and implemented. UW Health as implemented an osteoarthritis management program. The effectiveness of these programs compared to usual care is not known. https://www.uwhealth.org/orthopedic-surgery-rehab/knee-and-hip-comprehensive-non-surgical-osteoarthritis-management-clinic/51216 | 1 | Student will help with chart review of patient reported outcomes as well as evaluation of patient satisfaction and quality of care data from an established osteoarthritis program. Student may also have the opportunity to conduct patient interviews. | Student will need to have home access to health link and be able to work fairly independently but with good support and frequent check ins. | Use of Excel | approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | DPT students, MPH students, PhD students | a. Miller K, Galusha B, Baier L, Micek M. Management of knee and hip osteoarthritis in primary care. J Gen Intern Med. 2018;33(suppl 1):s251. b. Miller KA, Baier Manwell LM, Rabago D. Multimodal Care for Knee and Hip Osteoarthritis: A Pilot Feasibility Study of a Novel Approach to a Common Problem. WMJ. 2020 Mar; 119(1):44-47. c. Eyles JP, Hunter DJ, Bennell KL, Dziedzic KS, Hinman RS, van der Esch M, Holden MA, Bowden JL, Joint Effort Initiative Members & Collaborators (…, Miller K, et al). Priorities for the effective implementation of osteoarthritis management programs: An OARSI international consensus exercise. Osteoarthritis Cartilage. 2019 Sep; 27(9):1270-9 d. Miller K, Baier Manwell L, Osman F. Patient and Provider Perceptions of Knee and Hip Osteoarthritis Care: A Qualitative Study. Int Clin Pract. 2020; 74:e13627. | No | Linda Baier; Sheri Reinders | ||||||||||||
| 23/12/2021 | ccm@medicine.wisc.edu | Carol | Mitchell | PhD | Associate Professor | 608 | Medicine | Cardiovascular Medicine | Robert Dempsey, MD | dempsey@neurosurgery.wisc.edu | Neurological Surgery | Stroke Prevention in the Native American Population (Ultrasound markers) - the Oneida Nation | Stroke Prevention in the Native American Population - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will examine how novel ultrasound biomarkers are related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. | 1 | MD student role is to actively participate in the stroke prevention community program at the Oneida Nation, visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the ultrasound findings with a research team member to learn about carotid ultrasound imaging and will assist with ultrasound image analysis using software on approved project computers and perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how ultrasound measurements acquired with this project are associated with stroke risk factors in Native Americans. | Curious / multitasking / willing to learn new skills / teamwork | Approved, 2019-1550 | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Yes | Stephanie Wilbrand, PHD - research administrator for project, wilbrand@neurosurgery.wisc.edu | Yes | Stroke Prevention in the Native American Population (Ultrasound markers) - the Oneida Nation: Stroke Prevention in the Native American Population - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes compared to other US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will examine how novel ultrasound biomarkers are related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. ____________________________________________________________________________ Role - MD student role is to actively participate in the stroke prevention community program at the Oneida Nation, visits occur once a month to the Nation and the rest of the work is on site at UW. This will include reviewing a health history with participants, performing the American Heart Association Quiz with the participant to determine their individual risk factors for stroke, observing cognitive testing performed as part of this study, observing carotid ultrasound examinations, and observing health wellness discussions about resources available for reducing stroke risk factors. These activities will occur if on-site activities are permitted, if not the study activities of health history and stroke risk factor quiz will be virtual, and the MD student will review the ultrasound findings with a research team member to learn about carotid ultrasound imaging and will assist with ultrasound image analysis using software on approved project computers and perform data entry into the project database. Thus, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; with special focus on examining how ultrasound measurements acquired with this project are associated with stroke risk factors in Native Americans. ; IRB Status - Approved, 2019-1550; Skills - Curious / multitasking / willing to learn new skills / teamwork | Carol Mitchell, ccm@medicine.wisc.edu -- Co-Mentor: Robert Dempsey, MD dempsey@neurosurgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufs9Mp4vn0FzoBIqw8oQGwPesJd9A6E8etmC4YYpIdS1p8jp_lbYwoPOKcInLNZtwg | |||||||
| 20/12/2021 | emohr2@wisc.edu | Emma | Mohr | MD, PhD | Assistant Professor | 6.082.655.107 | Pediatrics | Infectious Diseases | Neurodevelopmental outcomes of children potentially exposed to Zika virus in utero | Neurodevelopmental outcomes of infants with potential Zika virus exposure: We are studying the neurodevelopmental outcomes of children who were born to Wisconsin women who traveled to Zika endemic regions during pregnancy. About 30% of children with known Zika virus infection during pregnancy have developmental deficits. The number of children with developmental deficits in our cohort of Wisconsin women with potential Zika virus exposure is not known yet. Our goal is to determine whether children with potential Zika-exposure are at higher risk for having developmental deficits compared with age-matched children with no prenatal travel to a Zika-endemic region. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ | 0 | Retrospective chart reviewer and data analyst | Proficient in Epic, Microsoft Excel and Word | IRB approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | PhD students | No | N/A | Yes | Neurodevelopmental outcomes of children potentially exposed to Zika virus in utero: Neurodevelopmental outcomes of infants with potential Zika virus exposure: We are studying the neurodevelopmental outcomes of children who were born to Wisconsin women who traveled to Zika endemic regions during pregnancy. About 30% of children with known Zika virus infection during pregnancy have developmental deficits. The number of children with developmental deficits in our cohort of Wisconsin women with potential Zika virus exposure is not known yet. Our goal is to determine whether children with potential Zika-exposure are at higher risk for having developmental deficits compared with age-matched children with no prenatal travel to a Zika-endemic region. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ ____________________________________________________________________________ Role - Retrospective chart reviewer and data analyst; IRB Status - IRB approved; Skills - Proficient in Epic, Microsoft Excel and Word | Emma Mohr, emohr2@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufmCLiTaLF-gGc5ao8EKV9Qqo9rL1Qt3n8IqoAvcC-1VmMDwyQwKiTwpubwWMBdqHU | ||||||||||
| 14/12/2021 | zmorris@humonc.wisc.edu | Zachary | Morris | MD/PhD | Assistant Professor | 6.082.632.603 | Human Oncology | Evaluating mechanisms of interaction between radiation therapies and immunotherapies | Preclinical and clinical investigations of therapeutic mechanisms whereby radiation may enhance response to immunotherapies. Specific study details can be tailored to the interests and goals of the student. | 0 | Perform laboratory research and analyses. | Supervision provided by senior member of the Morris lab. | Basic laboratory skills, ideally including mammalian cell culture, PCR, mouse handling, and/or flow cytometry | N/A | Yes | Yes | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Jagodinsky JC, Morris ZS. Priming and Propagating Anti-tumor Immunity: Focal Hypofractionated Radiation for in Situ Vaccination and Systemic Targeted Radionuclide Theranostics for Immunomodulation of Tumor Microenvironments. Semin Radiat Oncol. 2020 Apr;30(2):181-186. doi: 10.1016/j.semradonc.2019.12.008. PMID: 32381297. Patel RB, Ye M, Carlson PM, Jaquish A, Zangl L, Ma B, Wang Y, Arthur I, Xie R, Brown RJ, Wang X, Sriramaneni R, Kim K, Gong S, Morris ZS. Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial-Membrane-Coated Nanoparticles. Adv Mater. 2019 Oct 31(43):e1902626. doi: 10.1002/adma.201902626. Epub 2019 Sep 16. PMID: 31523868. Baniel CC, Heinze CM, Hoefges A, Sumiec EG, Hank JA, Carlson PM, Jin WJ, Patel R, Sriramaneni RN, Gillies SD, Erbe AK, Schwarz CN,Pieper AA, Rakhmilevich AL, Sondel PM and Morris ZS. In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response. Front. Immunol. 2020. Jul 24;11:1610. doi: 10.3389/fimmu.2020.01610. PMID: 32849544. Clark PA, Sriramaneni RN, Jin WJ, Jagodinsky JC, Bates AM, Jaquish AA, Anderson BR, Le T, Lubin JA, Chakravarty I, Arthur IA, Heinze CM, Guy EI, Kler J, Klar KA, Carlson PM, Kim K, Kuo JS, Morris ZS. In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. J Immunother Cancer. 2020 Jul;8(2):e000809. doi: 10.1136/jitc-2020-000809.PMID: 32690669. Jin WJ, Erbe AK, Schwarz CN, Jaquish AA, Anderson BR, Sriramaneni RN, Jagodinsky JC, Bates AM, Clark PA, Le T, Lan KH, Chen Y, Kim KM, Morris ZS. Tumor-specific antibody, cetuximab, enhances the in situ vaccine effect of radiation in immunologically cold head and neck squamous cell carcinoma. Front Immunol. 2020 Nov 12;11:591139. doi: 10.3389/fimmu.2020.591139. PMID: 33281820. | Yes | Raghava Sriramaneni | Evaluating mechanisms of interaction between radiation therapies and immunotherapies: Preclinical and clinical investigations of therapeutic mechanisms whereby radiation may enhance response to immunotherapies. Specific study details can be tailored to the interests and goals of the student. ____________________________________________________________________________ Role - Perform laboratory research and analyses.; IRB Status - N/A; Skills - Basic laboratory skills, ideally including mammalian cell culture, PCR, mouse handling, and/or flow cytometry | Zachary Morris, zmorris@humonc.wisc.edu -- Co-Mentor: | |||||||||||
| 12/01/2022 | samurray@medicine.wisc.edu | Samantha | Murray-Bainer | MD | Assistant Professor (CHS), Hospital Medicine Division | 3.033.455.997 | Medicine | Hospital Medicine | Alexis Waters, PA | awaters@uwhealth.org | Medicine | Hospital Medicine | The Reducing Revisits Study (Respiratory Emergency Visits using Implementation Science Interventions Tailored to Settings) | The REVISITS study is a multicenter initiative funded by the Society of Hospital Medicine and the COPD Foundation with the goal of reducing ER visits and readmissions for COPD management, in patients with COPD. We are one of the enrolling sites, and will be recruiting patients over the course of a year to participate in educational initiatives (making a COPD action plan and a post-discharge follow up call) with the hope that it improves their care and reduces their need for follow up visits. The involvement of the student would be to obtain consent from identified patients, develop a tailored COPD action plans with those patients, and call them in follow up. There would likely be opportunities for poster presentations and publications out of this experience. | 2 | Direct involvement with study participants, interpretation of data, primary author for posters | The creation of action plans will be done with assistance of mentors, but students will be given independence with interaction with patients and follow up calls | Motivational interviewing skills and good bedside manner | In process, awaiting approval | Yes | No (plan to use Dean's Office Funds) | Yes | This project will be ongoing for a year, and multiple students could be involved during the semesters | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | N/A | No | The Reducing Revisits Study (Respiratory Emergency Visits using Implementation Science Interventions Tailored to Settings): The REVISITS study is a multicenter initiative funded by the Society of Hospital Medicine and the COPD Foundation with the goal of reducing ER visits and readmissions for COPD management, in patients with COPD. We are one of the enrolling sites, and will be recruiting patients over the course of a year to participate in educational initiatives (making a COPD action plan and a post-discharge follow up call) with the hope that it improves their care and reduces their need for follow up visits. The involvement of the student would be to obtain consent from identified patients, develop a tailored COPD action plans with those patients, and call them in follow up. There would likely be opportunities for poster presentations and publications out of this experience. ____________________________________________________________________________ Role - Direct involvement with study participants, interpretation of data, primary author for posters; IRB Status - In process, awaiting approval; Skills - Motivational interviewing skills and good bedside manner | Samantha Murray-Bainer, samurray@medicine.wisc.edu -- Co-Mentor: Alexis Waters, PA awaters@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueZXfmF240AgGdGyYsh7th7-t8kIXbsJ5UVATrFqEMrFIDlIOZcdBtDhU8DjJ0zlfY | |||||
| 04/01/2022 | anand.narayan@wisc.edu | Anand | Narayan | MD, PhD | Associate Professor | 410 | Radiology | Breast Imaging | Health Care Disparities in Access to Imaging and Cancer Screening | Our current research projects include a wide variety of projects that evaluate disparities in access to imaging with a particular focus on cancer screening. Some of the areas of greatest current interested include evaluating "imaging deserts" specifically areas that lack access to high quality imaging facilities. We hypothesize that low income urban and rural areas will be less likely to have geographic access to high quality imaging services (e.g. diagnostic breast imaging centers, MRIs, lung cancer screening centers, breast imaging centers of excellence). These studies will rely on publicly available databases with freely available data that can be downloaded. As such we anticipate that this data will be readily available on June 1 so that participants will be able to complete the project by the end of August, leading to at least 1-2 abstract submissions by the end of August, leading to 1-2 manuscript submissions by the end of the calendar year. There will be additional ongoing longitudinal opportunities for students interested in health equity and diversity and inclusion research projects. | 0 | First author on manuscripts and presentations, additional publication opportunities to help with ongoing manuscripts | Strong commitment to health equity | N/A | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | No | Yes | aross@uwhealth.org | Yes | Health Care Disparities in Access to Imaging and Cancer Screening: Our current research projects include a wide variety of projects that evaluate disparities in access to imaging with a particular focus on cancer screening. Some of the areas of greatest current interested include evaluating "imaging deserts" specifically areas that lack access to high quality imaging facilities. We hypothesize that low income urban and rural areas will be less likely to have geographic access to high quality imaging services (e.g. diagnostic breast imaging centers, MRIs, lung cancer screening centers, breast imaging centers of excellence). These studies will rely on publicly available databases with freely available data that can be downloaded. As such we anticipate that this data will be readily available on June 1 so that participants will be able to complete the project by the end of August, leading to at least 1-2 abstract submissions by the end of August, leading to 1-2 manuscript submissions by the end of the calendar year. There will be additional ongoing longitudinal opportunities for students interested in health equity and diversity and inclusion research projects. ____________________________________________________________________________ Role - First author on manuscripts and presentations, additional publication opportunities to help with ongoing manuscripts; IRB Status - N/A; Skills - Strong commitment to health equity | Anand Narayan, anand.narayan@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufEt0pfdpoACF-N-0lRoTet_5CuE4o8K4g4Jf_0uHHQ9sRPzanpiNwl0pUkRhC_MeY | |||||||||
| 18/01/2022 | nemeth@ortho.wisc.edu | Blaise | Nemeth | MD | Associate Professor (CHS) | 608 | Orthopedics and Rehabilitation | Pamela Lang, MD | plang@ortho.wisc.edu | Orthopedics and Rehabilitation | Impact of Clubfoot on Sports Participation in Children | Multi-center survey study assessing sports participation amongst children with clubfeet | 1 | Assisting in phone follow-up, data acquisition by phone, local data analysis, abstract and manuscript writing | Must be able to identify when needing to ask for help; anticipate weekly check-ins with faculty and research team | RedCAP, Excel, excellent communication and phone skills | Approved | No | Yes | Yes | Shorter term projects | Not currently available to mentor other students | No | Heidi Ableidinger | Yes | Impact of Clubfoot on Sports Participation in Children: Multi-center survey study assessing sports participation amongst children with clubfeet ____________________________________________________________________________ Role - Assisting in phone follow-up, data acquisition by phone, local data analysis, abstract and manuscript writing; IRB Status - Approved; Skills - RedCAP, Excel, excellent communication and phone skills | Blaise Nemeth, nemeth@ortho.wisc.edu -- Co-Mentor: Pamela Lang, MD plang@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudD-29qa7zuWDKzngWRwQ3FVD3h-n-QBckrfZdKqOm693b9Yw-N-dX4qWsghf2tw6U | |||||||
| 04/01/2022 | nickel@ortho.wisc.edu | Brian | Nickel | MD | Assistant Professor | 6.084.406.420 | Orthopedics and Rehabilitation | Orthopedic Surgery | Decreasing Operating Room Traffic in Joint Replacement Surgery | Surgical site infections after joint replacement are devastating complications and are influenced by patient, surgical, and operating room environmental factors. It has been shown that excessive traffic in and out of the operating room with door openings and closings increases aerosolized particles and compromises air quality. In an effort to reduce the incidence of door openings door openings we seek to determine baseline status and study several factors which may lower this: hand sterilization process, physical barriers, staff education, etc. | 0 | Student will spend significant time getting clinical exposure to the field of orthopedics and both residents and faculty. The student will be in the operating room both scrubbing to understand concepts of joint replacement, but also observing traffic patters and devising ways to minimize door opening and closings. They will help faculty and residents then write the manuscript and presentations for publications. | none | none | Currently being submitted as a QI project | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Yes | nickel@ortho.wisc.edu | Yes | Decreasing Operating Room Traffic in Joint Replacement Surgery: Surgical site infections after joint replacement are devastating complications and are influenced by patient, surgical, and operating room environmental factors. It has been shown that excessive traffic in and out of the operating room with door openings and closings increases aerosolized particles and compromises air quality. In an effort to reduce the incidence of door openings door openings we seek to determine baseline status and study several factors which may lower this: hand sterilization process, physical barriers, staff education, etc. ____________________________________________________________________________ Role - Student will spend significant time getting clinical exposure to the field of orthopedics and both residents and faculty. The student will be in the operating room both scrubbing to understand concepts of joint replacement, but also observing traffic patters and devising ways to minimize door opening and closings. They will help faculty and residents then write the manuscript and presentations for publications.; IRB Status - Currently being submitted as a QI project; Skills - none | Brian Nickel, nickel@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf2v90mVtdSWmiMV5IsXp-Uez6WpP7MxRGsMYURbmwfBgzBiM97gm22g198B8nua5k | |||||||||
| 14/12/2021 | sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Assistant Prof (CHS) | 6.082.650.152 | Medicine | Nephrology | Incidence, risk factors and outcomes of avascular necrosis of joint in kidney transplant recipients | Avascular necrosis is a serious complication among kidney transplant recipients. However, there are no recent studies in this field. There are few studies with very small size of 10-15 patients. In this study, from UW we would like to find the incidence and risk factors of AVN and outcomes associated with AVN. | 0 | Student will be a primary investigator and lead author. Will work on literature search, brief data collection, data analysis and preparation of abstract and manuscript. Expected to submit abstract to the American society of Nephrology (ASN) and preparation of manuscript. | student will be independent and work on their time, will provide all guidance and support as needed | Not much, just need energy and enthusiasm | Pending | No | Not sure, may be DOM | Yes | Shorter term projects | Not currently available to mentor other students | No | N/A | No | Incidence, risk factors and outcomes of avascular necrosis of joint in kidney transplant recipients: Avascular necrosis is a serious complication among kidney transplant recipients. However, there are no recent studies in this field. There are few studies with very small size of 10-15 patients. In this study, from UW we would like to find the incidence and risk factors of AVN and outcomes associated with AVN. ____________________________________________________________________________ Role - Student will be a primary investigator and lead author. Will work on literature search, brief data collection, data analysis and preparation of abstract and manuscript. Expected to submit abstract to the American society of Nephrology (ASN) and preparation of manuscript. ; IRB Status - Pending ; Skills - Not much, just need energy and enthusiasm | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufHe2vjA6R2ziNpwOJzAqMaktrHRZ-AgW2ansQAp3Zpkz5I75U8U5lot7FeWHpcEEY | |||||||||
| 14/12/2021 | sparajuli@medicine.wisc.edu | Sandesh | Parajuli | MD | Assistant prof (CHS) | 6.082.650.152 | Medicine | Nephrology | Transplant | Risk factors and outcomes of CMV viremia among deceased donor kidney transplant recipients based on donor characteristics | CMV is a common viral infection in kidney transplant recipients. The most common risk factor for CMV post transplant is donor seropositive and recipient seronegative. However, there are multiple other risk factors. In this paired analysis, we will look for the various risk factors associated with CMV among deceased donor when both kidneys are transplanted to two different recipients at UW. Recently, we published our experience with same methods for another post transplant viral infection - BK. "Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on donor characteristics" by Isabel Breyer et al.PMID: 34825437 Isabel worked with us in 2021 summer for her Shapiro project. If interested please read that paper, as we will be mirroring the same study for different (CMV) infection | 0 | Student will work independent on their own time with guidance as needed. Will aim to submit abstract to the American society of Nephrology (ASN) and prepare manuscript for publication. Student/s will also need to have healthlink access and help with data collection | None, will mentor. Just need energy and enthusiasm to | pending | No | not sure, may be DOM | Yes | Shorter term projects, Research Electives for credit | Not currently available to mentor other students | No | N/A | No | Risk factors and outcomes of CMV viremia among deceased donor kidney transplant recipients based on donor characteristics: CMV is a common viral infection in kidney transplant recipients. The most common risk factor for CMV post transplant is donor seropositive and recipient seronegative. However, there are multiple other risk factors. In this paired analysis, we will look for the various risk factors associated with CMV among deceased donor when both kidneys are transplanted to two different recipients at UW. Recently, we published our experience with same methods for another post transplant viral infection - BK. "Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on donor characteristics" by Isabel Breyer et al.PMID: 34825437 Isabel worked with us in 2021 summer for her Shapiro project. If interested please read that paper, as we will be mirroring the same study for different (CMV) infection ____________________________________________________________________________ Role - Student will work independent on their own time with guidance as needed. Will aim to submit abstract to the American society of Nephrology (ASN) and prepare manuscript for publication. Student/s will also need to have healthlink access and help with data collection ; IRB Status - pending ; Skills - None, will mentor. Just need energy and enthusiasm to | Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufat8NfVrfrEmmrOJ5kaNEdLdA-zMW14LYH3RbDfaaJjpz8Ffipeg3vTDtVHldperQ | |||||||||
| 08/12/2021 | apeterson@pediatrics.wisc.edu | Amy | Peterson | MD, MS | Associate Professor of Pediatrics | 6.082.625.024 | Pediatrics | Pediatric Cardiology | Cascade Screening Family Members of Children with Familial Hypercholesterolemia | The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. Children who are diagnosed with Familial Hypercholesterolemia, the most common inherited form of high cholesterol, are often the first family member to be diagnosed. When this happens, all family members are supposed to be screened for the condition, but this does not always happen. We would like to systematically investigate this through a database analysis and chart review. Additionally, any student involved in this project would have the opportunity to attend PPCC at AFCH and take advantage of other clinical opportunities within the division of pediatric cardiology. | 0 | Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired. | This project requires a self-motivated learner and strong work ethic, but the research team will provide support for this project. | None | Student will participate in seeking IRB approval for the project | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Genetic Counseling students | No | Yes | Xiao Zhang, xiao.zhang@wisc.edu | Yes | Cascade Screening Family Members of Children with Familial Hypercholesterolemia: The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. Children who are diagnosed with Familial Hypercholesterolemia, the most common inherited form of high cholesterol, are often the first family member to be diagnosed. When this happens, all family members are supposed to be screened for the condition, but this does not always happen. We would like to systematically investigate this through a database analysis and chart review. Additionally, any student involved in this project would have the opportunity to attend PPCC at AFCH and take advantage of other clinical opportunities within the division of pediatric cardiology. ____________________________________________________________________________ Role - Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired.; IRB Status - Student will participate in seeking IRB approval for the project; Skills - None | Amy Peterson, apeterson@pediatrics.wisc.edu -- Co-Mentor: | |||||||||
| 17/12/2021 | epetty@wisc.edu | Elizabeth | Petty | MD | Senior Associate Dean, Academic Affairs; Professor of Pediatics | 6.082.190.575.608 | Academic Affairs | Pediatrics | Genetics | Optimizing Outcomes and Opportunities in Academic Medicine: Quality Improvement Research | The goal of this project is to advance innovative programming that is designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data can be mined, literature can be reviewed, and/or new data can be gathered (e.g., by focus groups, surveys) in areas that are high priority for ongoing for strategic improvement to optimize the learning environment to promote inclusive and equitable flourishing. Students will work closely with faculty and staff in academic affairs and be part of the strategic improvement team. They will gain knowledge and hands-on skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interest and experience, students will be able to participate in administrative leadership meetings, Building Community meetings, Kern National Network meetings, and clinic meetings/conferences. They will be engaged in quality improvement related to program development and accreditation. They will learn about accreditation, policies, and operations relevant to academic medicine. The specific research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. Faculty/staff co-mentors with subject area expertise will be identified. Past students have done projects related to career advising, wellness, curriculum, equity, and inclusion that have helped shape existing school programs. What are you interested in improving? | 2 | Project leader and manger, collaborative partner, innovative thinker! | Student(s) will meet with mentor(s) formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily available between formal meetings. Weekly group meetings will also be held with the members of the steering committee for strategic improvement within academic affairs. | Skills Required Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | Projects needing IRB will already have IRB in place, others will be Quality Improvement and IRB will not be required. | Yes | Yes | Yes | Research Electives for credit, Interested and funded to provide another yearlong mentoring opportunity | DPT students, Genetic Counseling students, MPH students, PhD students | Yes | Susan Jeannette | Unsure / Depends | Optimizing Outcomes and Opportunities in Academic Medicine: Quality Improvement Research: The goal of this project is to advance innovative programming that is designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data can be mined, literature can be reviewed, and/or new data can be gathered (e.g., by focus groups, surveys) in areas that are high priority for ongoing for strategic improvement to optimize the learning environment to promote inclusive and equitable flourishing. Students will work closely with faculty and staff in academic affairs and be part of the strategic improvement team. They will gain knowledge and hands-on skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interest and experience, students will be able to participate in administrative leadership meetings, Building Community meetings, Kern National Network meetings, and clinic meetings/conferences. They will be engaged in quality improvement related to program development and accreditation. They will learn about accreditation, policies, and operations relevant to academic medicine. The specific research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. Faculty/staff co-mentors with subject area expertise will be identified. Past students have done projects related to career advising, wellness, curriculum, equity, and inclusion that have helped shape existing school programs. What are you interested in improving? ____________________________________________________________________________ Role - Project leader and manger, collaborative partner, innovative thinker! ; IRB Status - Projects needing IRB will already have IRB in place, others will be Quality Improvement and IRB will not be required. ; Skills - Skills Required Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus. | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufdxtfnOelqjvVcr2gDNwA-O974Hw9ZoUekfPitiefb1qAkrEAWsaaZuP7HcYLx854 | ||||||||
| 17/12/2021 | epetty@wisc.edu | Elizabeth | Petty | MD | Professor of Pediatrics; Senior Associate Dean Academic Affairs | 608 | Pediatrics | Genetics | Academic Affairs | Advancing LGBTQ+/Gender Diversity, Inclusion, and Equity | The goal of this project is to use a quality improvement research focus to better understand how to better advance inclusion and equity for LGBTQ+ and non-binary/gender non-conforming individuals in health professions education programs through support services, curriculum, and/or co-/extra- curricular experiences. Depending on student specific interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement in this area, starting with literature reviews and needs assessments. The student(s) will help define the project goals and outcomes. Students will work closely with faculty and staff in academic affairs and our diversity programs. They will gain knowledge and skills that are relevant to careers in academic medicine and diversity, equity, and inclusion leadership with a particular focus on the LGBTQ+ and gender diverse community. This work will lead to opportunities for presentations, publications, and/or program improvement. Depending on interests and experience of students, they will have opportunities to participate in administrative, academic, and national meetings. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in public health or academic medicine. | 2 | The student(s) will play an active role in the design and development of the specific project goals and will be the leader of their particular mentored-project. | Student(s) will meet with mentor(s) formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily available to meet between formal meetings. | Must have a strong commitment to serve the LGBTQ+/gender diverse community. For this project, effective computer skills, communication, and collaboration skills are essential. Experience with surveys, focus groups, data analysis is a plus. | Will depend on project, IRB if needed will be obtained by PI prior to May 15, 2022. | Yes | Yes | Yes | Research Electives for credit, Interested and funded to provide another yearlong mentoring opportunity | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/) | Yes | Susan Jeannette jeannette@wisc.edu | Yes | Advancing LGBTQ+/Gender Diversity, Inclusion, and Equity : The goal of this project is to use a quality improvement research focus to better understand how to better advance inclusion and equity for LGBTQ+ and non-binary/gender non-conforming individuals in health professions education programs through support services, curriculum, and/or co-/extra- curricular experiences. Depending on student specific interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement in this area, starting with literature reviews and needs assessments. The student(s) will help define the project goals and outcomes. Students will work closely with faculty and staff in academic affairs and our diversity programs. They will gain knowledge and skills that are relevant to careers in academic medicine and diversity, equity, and inclusion leadership with a particular focus on the LGBTQ+ and gender diverse community. This work will lead to opportunities for presentations, publications, and/or program improvement. Depending on interests and experience of students, they will have opportunities to participate in administrative, academic, and national meetings. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in public health or academic medicine. ____________________________________________________________________________ Role - The student(s) will play an active role in the design and development of the specific project goals and will be the leader of their particular mentored-project. ; IRB Status - Will depend on project, IRB if needed will be obtained by PI prior to May 15, 2022.; Skills - Must have a strong commitment to serve the LGBTQ+/gender diverse community. For this project, effective computer skills, communication, and collaboration skills are essential. Experience with surveys, focus groups, data analysis is a plus. | Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudLMYtmL1Tp6hSY6cCIrhZIjp_3rp_IwzGSifHuAqJ7yxzxr1M6rUOaxb5UX9TO7K0 | ||||||||
| 07/12/2021 | vprabhakaran@uwhealth.org | Vivek | Prabhakaran | MD PhD | Associate Professor | 6.082.655.269 | Radiology | Neuroradiology | Advanced Neuroimaging Projects | The project will entail segmenting white matter lesions in stroke patients and using fMRI, DTI measures and relating it to behavioral outcomes. This will allow using JIM segmentation software which will semiautomate this process. We will use standard and possibly AI/Machine learning approaches to identify critical neuroimaging and clinical features that relates to stroke outcomes | 2 | Neuroimaging analyses | semiindependent | computer skills | approved IRB | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students | Yes | No | Veena Nair vnair@uwhealth.org | No | Advanced Neuroimaging Projects: The project will entail segmenting white matter lesions in stroke patients and using fMRI, DTI measures and relating it to behavioral outcomes. This will allow using JIM segmentation software which will semiautomate this process. We will use standard and possibly AI/Machine learning approaches to identify critical neuroimaging and clinical features that relates to stroke outcomes ____________________________________________________________________________ Role - Neuroimaging analyses; IRB Status - approved IRB; Skills - computer skills | Vivek Prabhakaran, vprabhakaran@uwhealth.org -- Co-Mentor: | |||||||||
| 07/12/2021 | mspulia@medicine.wisc.edu | Michael | Pulia | MD MS | Asst Professor | 708 | Emergency Medicine | Antimicrobial Stewardship in the Emergency Department | The student will work with Dr. Pulia to select an antibiotic stewardship focused sub-project from a variety of ongoing studies. Currently there are studies ongoing focused on skin and soft tissue infections, urinary tract infections and pneumonia. https://www.emed.wisc.edu/michael-pulia-md-ms | 0 | The student will be involved with their project planning/organization, data collection, analysis and scientific writing. | Moderate to high independence required | Experience working with electronic databases, including basic statistically analysis programming skills, are required | Approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, UW undergraduates interested in research | 1. Paul M, Pulia M, Pulcini C. Antibiotic Stewardship in the Emergency Department: Not to be Overlooked. Clinical Microbiology and Infection. 2020. In Press. 2. Pulia M, Wolf I, Schwei R, Chen D, Lepak A, Schulz L, Safdar N. Antibiotic Prescribing Patterns for COVID-19 in Two Emergency Departments with Rapid Procalcitonin. Infection Control and Hospital Epidemiology. 2020. In Press. 3. Pulia MS, Redwood B. Empiric Antibiotic Prescribing for Suspected Sepsis: A Stewardship Balancing Act. American Journal of the Medical Sciences. 2020. In-press. PMC6482602 4. Valmadrid LC, Schwei RJ, Maginot E, Pulia MS. The Impact of Healthcare Provider Relationships and Communication Dynamics on Urinary Tract Infection Management and Antibiotic Utilization for Long-Term Care Facility Residents Treated in the Emergency Department: A Qualitative Study. American Journal of Infection Control. 2020. Online ahead of print. PMC7348612 5. Pulia MS, Hesse S, Schwei RJ, Schulz LT, Sethi A, Hamedani A. Inappropriate Antibiotic Prescribing for Respiratory Conditions Does Not Improve Press Ganey Patient Satisfaction Scores in the Emergency Department. Open Forum Infectious Diseases. Editor’s Choice. 2020;7(6). PMC In Process | Yes | Rebecca Schwei rschwei@medicine.wisc.edu | Yes | Antimicrobial Stewardship in the Emergency Department: The student will work with Dr. Pulia to select an antibiotic stewardship focused sub-project from a variety of ongoing studies. Currently there are studies ongoing focused on skin and soft tissue infections, urinary tract infections and pneumonia. https://www.emed.wisc.edu/michael-pulia-md-ms ____________________________________________________________________________ Role - The student will be involved with their project planning/organization, data collection, analysis and scientific writing.; IRB Status - Approved; Skills - Experience working with electronic databases, including basic statistically analysis programming skills, are required | Michael Pulia, mspulia@medicine.wisc.edu -- Co-Mentor: | ||||||||||
| 08/12/2021 | mpuricelli@wisc.edu | Mike | Puricelli | MD | Assistant Professor (CHS) | 6.367.510.770 | Surgery | Otolaryngology | Epidemiologic analysis of anticipated perinatal airway obstruction | The epidemiology of airway intervention in anticipated perinatal airway obstruction (fetal jaw malformation, fetal neck mass, congenital high airway obstruction etc.) is unknown. Whenever severe obstruction is anticipated, resources can be mobilized to provide more rapid intervention or performance of an airway procedure on a partially delivered fetus while receiving continued placental gas exchange ('EXIT procedure'; see https://pubmed.ncbi.nlm.nih.gov/32891939/). These are resource intensive and better understanding of intervention needs could improve treatment allocation. A diagnosis and procedure code-based search strategy has been developed. The project will involve addition of older (such as ICD-9 codes) to the search strategy to permit multiyear analysis. Once complete, a coding template will be used to help STARP (https://www.surgery.wisc.edu/research/statistical-analysis-and-research-programming-starp-core/) researchers with coding the data search. The data will be reviewed, interpreted and prepared for publication. Participating student(s) must complete the HCUP database user agreement to participate in the project. In addition, a collaboration between Maternal Fetal Medicine, Pediatric/Fetal Surgery and Pediatric Otolaryngology involves creation of a registry to study perinatal outcomes across institutions. There may be opportunities for the fellow to participate in the registry creation project. | 0 | Please see above | Ability to cross index ICD-9/ICD-10 medical diagnoses. Willingness to learn basic data coding methods. Statistical background is a plus but not required. | N/A | No | Plan to use divisional funds (approval requested) | I do with the assistance of STARP researcher Manasa Venkatesh. | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students | No | Yes | N/A | Yes | Epidemiologic analysis of anticipated perinatal airway obstruction: The epidemiology of airway intervention in anticipated perinatal airway obstruction (fetal jaw malformation, fetal neck mass, congenital high airway obstruction etc.) is unknown. Whenever severe obstruction is anticipated, resources can be mobilized to provide more rapid intervention or performance of an airway procedure on a partially delivered fetus while receiving continued placental gas exchange ('EXIT procedure'; see https://pubmed.ncbi.nlm.nih.gov/32891939/). These are resource intensive and better understanding of intervention needs could improve treatment allocation. A diagnosis and procedure code-based search strategy has been developed. The project will involve addition of older (such as ICD-9 codes) to the search strategy to permit multiyear analysis. Once complete, a coding template will be used to help STARP (https://www.surgery.wisc.edu/research/statistical-analysis-and-research-programming-starp-core/) researchers with coding the data search. The data will be reviewed, interpreted and prepared for publication. Participating student(s) must complete the HCUP database user agreement to participate in the project. In addition, a collaboration between Maternal Fetal Medicine, Pediatric/Fetal Surgery and Pediatric Otolaryngology involves creation of a registry to study perinatal outcomes across institutions. There may be opportunities for the fellow to participate in the registry creation project. ____________________________________________________________________________ Role - Please see above; IRB Status - N/A; Skills - Ability to cross index ICD-9/ICD-10 medical diagnoses. Willingness to learn basic data coding methods. Statistical background is a plus but not required. | Mike Puricelli, mpuricelli@wisc.edu -- Co-Mentor: | ||||||||||
| 05/01/2022 | mramrat@medicine.wisc.edu | Mohun | Ramratnam | MD | Associate Professor | 4.438.041.406 | Medicine | Cardiovascular Medicine | Modulating cardiac mitochondrial physiology and metabolism to treat ischemic heart disease and heart failure. | My laboratory seeks to identify novel therapies to treat heart disease by studying and understanding cardiac metabolism. Specifically, my laboratory studies the cardiac sulfonylurea receptor and mitochondrial potassium channels. We use transgenically altered mice and pharmacologic modulation of these proteins to understand their roles in normal and disease states. In our laboratory we study isolated heart preparations as a model for heart attacks as well as the pathophysiological role these proteins have on mitochondrial biology and cardiac metabolism. Currently we are trying to understand how a compound that supposedly blocks mitochondrial potassium transport affects the heart during times of stress. The project entails isolating cardiomyocytes from adult mice, treating them with the substances of interest and assessing mitochondrial function. In another aspect of the project we are subjecting mouse hearts to the substances of interest on an organ perfusion system to see whether they tolerate ischemic insults. | 0 | The student will study mitochondrial physiology from cardiac cells or isolated mitochondria from mouse hearts. They will become an integral member of the lab and design and conduct experiments under my direct and in direct supervision to explore how different strains of mice or different compounds affect cardiac metabolism. | Fair amount of independence | Basic lab skills, pipetting. Good lab etiquette. Record keeping. basic microscope skills. | Approval | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | Not currently available to mentor other students | No | Martin Lea | No | Modulating cardiac mitochondrial physiology and metabolism to treat ischemic heart disease and heart failure. : My laboratory seeks to identify novel therapies to treat heart disease by studying and understanding cardiac metabolism. Specifically, my laboratory studies the cardiac sulfonylurea receptor and mitochondrial potassium channels. We use transgenically altered mice and pharmacologic modulation of these proteins to understand their roles in normal and disease states. In our laboratory we study isolated heart preparations as a model for heart attacks as well as the pathophysiological role these proteins have on mitochondrial biology and cardiac metabolism. Currently we are trying to understand how a compound that supposedly blocks mitochondrial potassium transport affects the heart during times of stress. The project entails isolating cardiomyocytes from adult mice, treating them with the substances of interest and assessing mitochondrial function. In another aspect of the project we are subjecting mouse hearts to the substances of interest on an organ perfusion system to see whether they tolerate ischemic insults. ____________________________________________________________________________ Role - The student will study mitochondrial physiology from cardiac cells or isolated mitochondria from mouse hearts. They will become an integral member of the lab and design and conduct experiments under my direct and in direct supervision to explore how different strains of mice or different compounds affect cardiac metabolism. ; IRB Status - Approval; Skills - Basic lab skills, pipetting. Good lab etiquette. Record keeping. basic microscope skills. | Mohun Ramratnam, mramrat@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufj-AwEEUTZu7NpZoDUQ5fn3eat2TJJ3N-GHFPFl3bA2RZkeYk6stoROzQn9TjGSXg | |||||||||
| 05/01/2022 | mramrat@medicine.wisc.edu | Mohun | Ramratnam | MD | Associate Professor | 7.082.683.577 | Medicine | Cardiovascular Medicine | The isolation and study of coronary endothelium from humans | Vascular disease are an major health problem and translation of discoveries to the clinic are challenging as molecular vascular biology research has been mostly conducted with cell culture and animal models. In this project, we propose to isolated and characterize endothelial cells from humans who undergo minimally invasive cardiac catheteization procedures. The equipment used in minimally invasive cardiac procedures are discarded but have been shown to be coated with patient endothelial cell. In this project, a student will perfect a protocol to isolate and characterize vascular cells from equipment used during humans undergoing vascular procedures. We will assess the different phenotype of cells gained from different human sites and also from different equipment used. | 0 | The student will harvest equipment from the cardiac catheterization laboratory and treat the equipment in order to fix the vascular cells. Flow cytometry or another isolating process will be employed to assess the yield of cells. Then various biochemical benchtop assessments will be done to assess the integrity and functionality of the vascular cells. | fair | Fair to Good lab bench skills (Pippette, centrifuge, biosafety hood) | approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | Not currently available to mentor other students | No | Martin Lea | No | The isolation and study of coronary endothelium from humans: Vascular disease are an major health problem and translation of discoveries to the clinic are challenging as molecular vascular biology research has been mostly conducted with cell culture and animal models. In this project, we propose to isolated and characterize endothelial cells from humans who undergo minimally invasive cardiac catheteization procedures. The equipment used in minimally invasive cardiac procedures are discarded but have been shown to be coated with patient endothelial cell. In this project, a student will perfect a protocol to isolate and characterize vascular cells from equipment used during humans undergoing vascular procedures. We will assess the different phenotype of cells gained from different human sites and also from different equipment used. ____________________________________________________________________________ Role - The student will harvest equipment from the cardiac catheterization laboratory and treat the equipment in order to fix the vascular cells. Flow cytometry or another isolating process will be employed to assess the yield of cells. Then various biochemical benchtop assessments will be done to assess the integrity and functionality of the vascular cells.; IRB Status - approved; Skills - Fair to Good lab bench skills (Pippette, centrifuge, biosafety hood) | Mohun Ramratnam, mramrat@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf0sqQK9Eg0BCaBbi-GUTxL65b5VLoqijQkP6HTHAJ5RRXjmFnvgchAuWvoD3MGqKE | |||||||||
| 11/01/2022 | jrehm@wisc.edu | Jennifer | Rehm | MD | Assistant Professor | 6.083.348.590 | Pediatrics | Endocrine and Diabetes | Kelsey Lewis | aklewis2@wisc.edu | Other | Center for Research on Gender and Women | Intersex Prevalence and Clinical Response | This project aims to determine how common variations of sex development (VSDs) are in the pediatric (ages 0-18) patient population in the UW Health System, and how these patients were responded to and treated. The primary goal of this project is to generate data necessary to advocate for institutional support for a Gender & Sex Development Program that has a stakeholder engagement program and prioritizes bodily autonomy for all patients. Aim 1. Determine prevalence of VSDs in UW Health System. 1.1 Using the TriNetX (https://live.trinetx.com/) platform to query de-identified patient data for diagnostic codes (ICD 9 and 10) and estimate prevalence based on diagnostic codes. 1.2 Perform IRB-approved review of electronic medical records for specific diagnoses. Aim 2. Determine frequency and type of medical response to patients identified in Aim 1. 2.1 Using TriNetX, determine how frequently patients identified in Aim 1 underwent medical intervention and what these interventions were. 2.2 Perform IRB-approved review of electronic medical records for detailed descriptions of surgical interventions, hormonal interventions, relevant medications and procedures, referrals, and any notes related to decision-making. First, we aim to determine the number of children with variations of sex development or intersex traits who are patients in the UW Health System. The number of these children has been initially examined using the TriNetX platform, but examination through electronic medical record review is necessary in order to confirm diagnoses and identify co-occurring diagnoses. Data collection through TriNetX determined that, as of 4/17/2021, of our pediatric (aged 0-18) population (148,102 patients), the UW Health System has 1,710 patients diagnosed with hypospadias or another congenital male genital organ difference, such as testis absence, hidden penis, etc. We have 210 pediatric patients with a congenital variation of the uterus, cervix, or other female-typical genitalia. We have 140 pediatric patients diagnosed with sex chromosome variations including Turner’s syndrome, Klinefelter’s syndrome, and chimerism, 60 pediatric patients with congenital adrenogenital disorders associated with enzyme deficiency, such as congenital adrenal hyperplasia, 10 pediatric patients diagnosed with Androgen Insensitivity Syndrome, and 30 pediatric patients with a diagnosis of “indeterminate sex,” “pseudohermaphroditism,” or “hermaphroditism.” Overall, 2,910 or 1.96% of our pediatric patients have one or more of the variations of sex development examined in the TriNetX platform. For these 2,910 children, after either confirming their diagnoses or removing them from the study, we will examine how children with confirmed diagnoses were treated and what resources they were or weren’t able to access. Specifically, we ask: What specialties were these children referred to? Did they meet with surgery, urology, gynecology, endocrinology, psychiatry, and/or social work? Next, we ask what medical interventions, such as hormones, medications, surgeries, and other procedures, were recommended and/or performed. Through this project, we will determine whether children in our university’s health system have undergone irreversible medically unnecessary interventions, and if so, how many. Overall, this project lays the groundwork for developing a clinic that prioritizes patient care and stakeholder engagement. | 2 | chart review and data entry | moderate -student will be trained on chart review with supervision and back up help avalialble | use of Healthlink, familiarization with Red Cap is helpful | Approved | Yes | Yes | Yes | Shorter term projects, Research Electives for credit | Genetic Counseling students, MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | Mckenzy Suhr |
Yes | Intersex Prevalence and Clinical Response: This project aims to determine how common variations of sex development (VSDs) are in the pediatric (ages 0-18) patient population in the UW Health System, and how these patients were responded to and treated. The primary goal of this project is to generate data necessary to advocate for institutional support for a Gender & Sex Development Program that has a stakeholder engagement program and prioritizes bodily autonomy for all patients. Aim 1. Determine prevalence of VSDs in UW Health System. 1.1 Using the TriNetX (https://live.trinetx.com/) platform to query de-identified patient data for diagnostic codes (ICD 9 and 10) and estimate prevalence based on diagnostic codes. 1.2 Perform IRB-approved review of electronic medical records for specific diagnoses. Aim 2. Determine frequency and type of medical response to patients identified in Aim 1. 2.1 Using TriNetX, determine how frequently patients identified in Aim 1 underwent medical intervention and what these interventions were. 2.2 Perform IRB-approved review of electronic medical records for detailed descriptions of surgical interventions, hormonal interventions, relevant medications and procedures, referrals, and any notes related to decision-making. First, we aim to determine the number of children with variations of sex development or intersex traits who are patients in the UW Health System. The number of these children has been initially examined using the TriNetX platform, but examination through electronic medical record review is necessary in order to confirm diagnoses and identify co-occurring diagnoses. Data collection through TriNetX determined that, as of 4/17/2021, of our pediatric (aged 0-18) population (148,102 patients), the UW Health System has 1,710 patients diagnosed with hypospadias or another congenital male genital organ difference, such as testis absence, hidden penis, etc. We have 210 pediatric patients with a congenital variation of the uterus, cervix, or other female-typical genitalia. We have 140 pediatric patients diagnosed with sex chromosome variations including Turner’s syndrome, Klinefelter’s syndrome, and chimerism, 60 pediatric patients with congenital adrenogenital disorders associated with enzyme deficiency, such as congenital adrenal hyperplasia, 10 pediatric patients diagnosed with Androgen Insensitivity Syndrome, and 30 pediatric patients with a diagnosis of “indeterminate sex,” “pseudohermaphroditism,” or “hermaphroditism.” Overall, 2,910 or 1.96% of our pediatric patients have one or more of the variations of sex development examined in the TriNetX platform. For these 2,910 children, after either confirming their diagnoses or removing them from the study, we will examine how children with confirmed diagnoses were treated and what resources they were or weren’t able to access. Specifically, we ask: What specialties were these children referred to? Did they meet with surgery, urology, gynecology, endocrinology, psychiatry, and/or social work? Next, we ask what medical interventions, such as hormones, medications, surgeries, and other procedures, were recommended and/or performed. Through this project, we will determine whether children in our university’s health system have undergone irreversible medically unnecessary interventions, and if so, how many. Overall, this project lays the groundwork for developing a clinic that prioritizes patient care and stakeholder engagement. ____________________________________________________________________________ Role - chart review and data entry; IRB Status - Approved; Skills - use of Healthlink, familiarization with Red Cap is helpful | Jennifer Rehm, jrehm@wisc.edu -- Co-Mentor: Kelsey Lewis aklewis2@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuezHG2Fk2TX0jJHlAHzxvzq46n60wAveS0H77U8OjmdF8K9puSG00hJzpdyEb0WDug | |||||
| 07/12/2021 | richardsk@urology.wisc.edu | Kyle | Richards | MD FACS | Associate Professor | 608 | Urology | Urologic Surgery Health Services Researcg | I have been working with medical students via the Shapiro program for 6 consecutive years. My goal is to train future leaders in medicine and we tailor the research to fit the goals of the student. I also enjoy getting the students in the operating room once a week to view robotic surgery. I work with a research team that includes project coordinators, research assistants, and biostatisticians. We can tailor the research project based on the goals and interests of the student. If the student prefers a database type of project, we are building several institutional bladder cancer databases to study outcomes in patients with bladder cancer. If the student is interested in this type of work, they would help build these datasets by reviewing charts in the electronic medical record and work towards analyzing the data for publications. In addition, we have built a Wisconsin Bladder Cancer Network (WiBCaN) to engage a group of patients with bladder cancer to assist the research team in identifying patient-centered research priorities. Currently, we have enrolled 200 patients in WiBCaN. The student would assist the research team in facilitation of focus groups with this engaged cohort as well as compilation and analysis of data from surveys that were sent to patients with bladder cancer. https://urology.wisc.edu/blog/staff/richards-md-facs-kyle-a/ | 0 | Assist the research team on the project of their choosing. | Moderate | Committed, hard working, inquisitive, enthusiastic | Exempt from IRB | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | No | mussehl@urology.wisc.edu | No | Urologic Surgery Health Services Researcg: I have been working with medical students via the Shapiro program for 6 consecutive years. My goal is to train future leaders in medicine and we tailor the research to fit the goals of the student. I also enjoy getting the students in the operating room once a week to view robotic surgery. I work with a research team that includes project coordinators, research assistants, and biostatisticians. We can tailor the research project based on the goals and interests of the student. If the student prefers a database type of project, we are building several institutional bladder cancer databases to study outcomes in patients with bladder cancer. If the student is interested in this type of work, they would help build these datasets by reviewing charts in the electronic medical record and work towards analyzing the data for publications. In addition, we have built a Wisconsin Bladder Cancer Network (WiBCaN) to engage a group of patients with bladder cancer to assist the research team in identifying patient-centered research priorities. Currently, we have enrolled 200 patients in WiBCaN. The student would assist the research team in facilitation of focus groups with this engaged cohort as well as compilation and analysis of data from surveys that were sent to patients with bladder cancer. https://urology.wisc.edu/blog/staff/richards-md-facs-kyle-a/ ____________________________________________________________________________ Role - Assist the research team on the project of their choosing.; IRB Status - Exempt from IRB; Skills - Committed, hard working, inquisitive, enthusiastic | Kyle Richards, richardsk@urology.wisc.edu -- Co-Mentor: | ||||||||||
| 24/01/2022 | ARoss@uwhealth.org | Andrew | Ross | MD MPH | Assistant Professor | Radiology | Musculoskeletal Imaging and Intervention | Anand Narayan | ANarayan@uwhealth.org | Radiology | Health Equity in Radiology: Creation of a Publicly Accessible, Searchable Database | Radiology plays a key role in the health care system and the well-publicized health inequities based on patient race/ethnicity found elsewhere in the health care system also exist within radiology. As interest in health equity within radiology builds, there is a need to quickly access the existing body of literature on this topic. In this project, participating students will construct a search to identify publications on health equity within radiology; review the papers to find those meeting inclusion criteria; and summarize their contents within a well-organized database that will be published to our Department’s website. As part of the process, students will follow a guided curriculum on health equity and learn or refine a number of new skills including how to conduct a systematic review; data management; database creation; and web skills. We will plan to submit an abstract on this process to one of the academic radiology meetings. Working within the Department of Radiology on a Shapiro research project also gives you access to a number of other benefits including career development talks, clinical shadowing opportunities, faculty facilitated small group mentoring, and support for scholarly productivity. | 0 | First author on abstracts/manuscripts. Perform systematic search, data extraction, database management, web publishing | Moderate | Willingness to learn | N/A | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | MPH students | No | Lorene Seman |
Yes | Health Equity in Radiology: Creation of a Publicly Accessible, Searchable Database: Radiology plays a key role in the health care system and the well-publicized health inequities based on patient race/ethnicity found elsewhere in the health care system also exist within radiology. As interest in health equity within radiology builds, there is a need to quickly access the existing body of literature on this topic. In this project, participating students will construct a search to identify publications on health equity within radiology; review the papers to find those meeting inclusion criteria; and summarize their contents within a well-organized database that will be published to our Department’s website. As part of the process, students will follow a guided curriculum on health equity and learn or refine a number of new skills including how to conduct a systematic review; data management; database creation; and web skills. We will plan to submit an abstract on this process to one of the academic radiology meetings. Working within the Department of Radiology on a Shapiro research project also gives you access to a number of other benefits including career development talks, clinical shadowing opportunities, faculty facilitated small group mentoring, and support for scholarly productivity. ____________________________________________________________________________ Role - First author on abstracts/manuscripts. Perform systematic search, data extraction, database management, web publishing; IRB Status - N/A; Skills - Willingness to learn | Andrew Ross, ARoss@uwhealth.org -- Co-Mentor: Anand Narayan ANarayan@uwhealth.org | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucQ30iZcvptUeaf-fZj6wuyyZ2R1UyRTALROEpK-9nRdVRgtyQIT6rIuje1eoyYVJc | |||||||
| 13/12/2021 | jdroth2@wisc.edu | Joshua | Roth | PhD | Assistant Professor | Orthopedics and Rehabilitation | Richard L. Illgen, II, M.D., Professor CHS | Illgen@ortho.wisc.edu | Orthopedics and Rehabilitation | Functional Phenotyping of Patients with Knee Osteoarthritis | Despite advances in surgical techniques and technologies to more precisely achieve a desired alignment and soft tissue balance, the prevalence of unsatisfied patients and suboptimal function after total knee arthroplasty (TKA) remain unacceptably high. Traditional targets used with these advanced technologies do not account for the anatomy, biomechanics, demographics, or psychosocial status of a particular patient. Accordingly, our objective is to identify functional patient phenotypes that will likely benefit from personalized targets for alignment and soft tissue balance. We will recruit patients scheduled to undergo TKA from my collaborators’ high-volume clinics. We will identify functional phenotypes using a machine learning clustering algorithm (k-means). Our expected outcome is a set of functional phenotypes that will be the focus of a follow-up randomized controlled trial to evaluate improvements in outcomes using personalized targets for alignment and soft tissue balance, which we believe are the next step towards personalize medicine in TKA. Our goal is that the student on this project would produce a publishable research product (abstract or paper) by the end of the project. My lab website is bamlab.wisc.edu. | 0 | Assistance with clinical exams and patient follow-up. Also opportunities to observe total knee arthroplasties and clinic appointments. | Desire to learn. Prior experience with human subjects research desired, but not required. | Application in progress. | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | DPT students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | N/A | No | Functional Phenotyping of Patients with Knee Osteoarthritis: Despite advances in surgical techniques and technologies to more precisely achieve a desired alignment and soft tissue balance, the prevalence of unsatisfied patients and suboptimal function after total knee arthroplasty (TKA) remain unacceptably high. Traditional targets used with these advanced technologies do not account for the anatomy, biomechanics, demographics, or psychosocial status of a particular patient. Accordingly, our objective is to identify functional patient phenotypes that will likely benefit from personalized targets for alignment and soft tissue balance. We will recruit patients scheduled to undergo TKA from my collaborators’ high-volume clinics. We will identify functional phenotypes using a machine learning clustering algorithm (k-means). Our expected outcome is a set of functional phenotypes that will be the focus of a follow-up randomized controlled trial to evaluate improvements in outcomes using personalized targets for alignment and soft tissue balance, which we believe are the next step towards personalize medicine in TKA. Our goal is that the student on this project would produce a publishable research product (abstract or paper) by the end of the project. My lab website is bamlab.wisc.edu. ____________________________________________________________________________ Role - Assistance with clinical exams and patient follow-up. Also opportunities to observe total knee arthroplasties and clinic appointments.; IRB Status - Application in progress.; Skills - Desire to learn. Prior experience with human subjects research desired, but not required. | Joshua Roth, jdroth2@wisc.edu -- Co-Mentor: Richard L. Illgen, II, M.D., Professor CHS Illgen@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue_R_7VEQYjp-6S3NZCiD40sb7-y31dpyHb7gndycjEi8Blx9Og9j-FZBqjoe89dKY | |||||||||
| 09/01/2022 | eric.ruedinger@ge.com | Eric | Ruedinger | BBA | GM, Anesthesia & Respiratory Care (GE Healthcare) | 414 | Other | GE Healthcare | Jack Page | John.Page@ge.com | Other | GE Healthcare | GE Healthcare Digital Product Management Internship | Background Hospitals are facing pressures to reduce cost and do more with less resources while constantly having to adapt to rapidly evolving internal and external trends. At the same time, the expectation for superior quality of care is only increasing. This is a tough balance to strike and creates numerous new challenges. Some of these challenges are driving practice changes, while some are the result of practice changes. Anesthesia and the OR are very important parts of the hospital. There are 100s of millions of major surgeries that occur globally each year. In fact, 1 out of 25 people will have such a procedure in a given year. The OR represents 40% of a hospital’s costs and 60% of its revenues. So there can be significant impact on patient care by improving perioperative care. But making improvements involves changing current practice which is often very difficult. Often, the right level of visibility into the key metrics & measures that optimize anesthesia performance is unavailable. This means the right evidence to drive the required behavior changes cannot be easily obtained, making it difficult to achieve a targeted goal or to minimize variability in anesthesia practice in general. Further, even if the data is available, it is often difficult to quickly interpret or easily put into a workflow. Objective Uncover a priority challenge in the perioperative care environment for that machine data can be used to drive a practice change to improve the challenge. Work with a software scrum team and lead the user facing design of an application to provide visibility to the right actionable data in the right way to help drive this change. Implement the application into the hospital workflow and drive the change management process to generate the desired outcome. Project Steps & Outcomes Part 1: 1. Work with anesthesia and perioperative staff to uncover a high priority quality improvement project (could be economic, clinical, or operationally driven) that may be solved with the interpretation and display of perioperative machine data 2. Uncover, understand, and define the problem statement thoroughly 3. Formulate acceptable requirements for a solution that may solve that challenge. • The solution should use anesthesia and/or patient monitoring data • The solution should avoid any manual entries and be algorithmically driven • The solution should include the key actionable information necessary to show evidence and drive a behavior change • The solution should be simply designed • The solution must be a digital application/dashboard that operates within the GEHC platform 4. Work closely with a software scrum team to lead the design efforts of the solution 5. Iterate on the design by providing feedback and getting feedback from the anesthesia and perioperative staff, with your challenge in mind 6. Finalize the design Part 2: 1. Work with SW scrum team and industry partner to deploy the new application into the hospital environment 2. Lead the initiative to use the new application to drive the desired behavior change 3. Influence factory using the evidence generated by the application to make a change 4. Monitor and drive this behavior change over time with select hospital staff 5. Show an improvement through use of the application within the hospital environment | 2 | To get experience with product development and management within a medical technology company. Details in project description. | n/a | n/a | No | n/a | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Talia Cawrse - Talia.Cawrse@ge.com Jack Page - John.Page@ge.com | No | GE Healthcare Digital Product Management Internship: Background Hospitals are facing pressures to reduce cost and do more with less resources while constantly having to adapt to rapidly evolving internal and external trends. At the same time, the expectation for superior quality of care is only increasing. This is a tough balance to strike and creates numerous new challenges. Some of these challenges are driving practice changes, while some are the result of practice changes. Anesthesia and the OR are very important parts of the hospital. There are 100s of millions of major surgeries that occur globally each year. In fact, 1 out of 25 people will have such a procedure in a given year. The OR represents 40% of a hospital’s costs and 60% of its revenues. So there can be significant impact on patient care by improving perioperative care. But making improvements involves changing current practice which is often very difficult. Often, the right level of visibility into the key metrics & measures that optimize anesthesia performance is unavailable. This means the right evidence to drive the required behavior changes cannot be easily obtained, making it difficult to achieve a targeted goal or to minimize variability in anesthesia practice in general. Further, even if the data is available, it is often difficult to quickly interpret or easily put into a workflow. Objective Uncover a priority challenge in the perioperative care environment for that machine data can be used to drive a practice change to improve the challenge. Work with a software scrum team and lead the user facing design of an application to provide visibility to the right actionable data in the right way to help drive this change. Implement the application into the hospital workflow and drive the change management process to generate the desired outcome. Project Steps & Outcomes Part 1: 1. Work with anesthesia and perioperative staff to uncover a high priority quality improvement project (could be economic, clinical, or operationally driven) that may be solved with the interpretation and display of perioperative machine data 2. Uncover, understand, and define the problem statement thoroughly 3. Formulate acceptable requirements for a solution that may solve that challenge. • The solution should use anesthesia and/or patient monitoring data • The solution should avoid any manual entries and be algorithmically driven • The solution should include the key actionable information necessary to show evidence and drive a behavior change • The solution should be simply designed • The solution must be a digital application/dashboard that operates within the GEHC platform 4. Work closely with a software scrum team to lead the design efforts of the solution 5. Iterate on the design by providing feedback and getting feedback from the anesthesia and perioperative staff, with your challenge in mind 6. Finalize the design Part 2: 1. Work with SW scrum team and industry partner to deploy the new application into the hospital environment 2. Lead the initiative to use the new application to drive the desired behavior change 3. Influence factory using the evidence generated by the application to make a change 4. Monitor and drive this behavior change over time with select hospital staff 5. Show an improvement through use of the application within the hospital environment ____________________________________________________________________________ Role - To get experience with product development and management within a medical technology company. Details in project description.; IRB Status - n/a; Skills - n/a | Eric Ruedinger, eric.ruedinger@ge.com -- Co-Mentor: Jack Page John.Page@ge.com | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufx2Hj-3x6-xKlbVGlaofx0bg6n1OnZs8Sgk4rPfGeY58x5mc7eAAEXOc9Bker2ocs | ||||||
| 28/01/2022 | eruedinger@wisc.edu | Emily | Ruedinger | MD, MEd | Assistant Professor | Pediatrics | General Pediatrics and Adolescent Medicine | Education for CHANGE- a social justice curriculum | Our pediatrics residency program has developed and implemented a longitudinal curriculum on social justice, diversity, equity and inclusion: Education for CHANGE (Education for Changemakers in History & power, ANti-Racism, challenGing oppression, and promoting Equity). Materials were cultivated from a variety of sources, both within and outside of the medical field. While the ultimate goal is to move toward a more just future, including achieving health equity for our patients, as a more proximate goal we focused this curriculum’s objectives on shifting learners’ knowledge, skills and attitudes. Topics include: historical foundations of race; power and oppression; intersectionality; identity and belonging; bias; microaggressions; tokenism; white fragility; and more. Read more about the curriculum at https://www.pediatrics.wisc.edu/education/residency-program/diversity-equity-inclusion-and-anti-racism/ Now that this curriculum has been designed, developed and implemented, we would like to shift toward dissemination. | 0 | This is a curriculum evaluation and dissemination project. This project will entail reviewing the current curricular materials; literature/resource review to update the curricula and ensure new, relevant content is incorporated; standardizing citations of content and images; and preparation for online dissemination (dissemination site TBD). The student(s) will also be guided in first-authoring a joural publication regarding the impact of this curriculum using curriculum evaluation surveys (already collected). | writing, visual design (for slide materials), PowerPoint, communication, literature/curricular materials search (both within medical education and in other relevant fields), commitment to and interest in social justice, collaboration, organization | N/A | No | No (plan to use Dean's Office Funds) | Student will need computer and internet access. May use GPAM office computer if needed. | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Yes | Bradley Kerr bkerr@wisc.edu; Christine Richards crichards9@wisc.edu | Unsure / Depends | Education for CHANGE- a social justice curriculum: Our pediatrics residency program has developed and implemented a longitudinal curriculum on social justice, diversity, equity and inclusion: Education for CHANGE (Education for Changemakers in History & power, ANti-Racism, challenGing oppression, and promoting Equity). Materials were cultivated from a variety of sources, both within and outside of the medical field. While the ultimate goal is to move toward a more just future, including achieving health equity for our patients, as a more proximate goal we focused this curriculum’s objectives on shifting learners’ knowledge, skills and attitudes. Topics include: historical foundations of race; power and oppression; intersectionality; identity and belonging; bias; microaggressions; tokenism; white fragility; and more. Read more about the curriculum at https://www.pediatrics.wisc.edu/education/residency-program/diversity-equity-inclusion-and-anti-racism/ Now that this curriculum has been designed, developed and implemented, we would like to shift toward dissemination. ____________________________________________________________________________ Role - This is a curriculum evaluation and dissemination project. This project will entail reviewing the current curricular materials; literature/resource review to update the curricula and ensure new, relevant content is incorporated; standardizing citations of content and images; and preparation for online dissemination (dissemination site TBD). The student(s) will also be guided in first-authoring a joural publication regarding the impact of this curriculum using curriculum evaluation surveys (already collected). ; IRB Status - N/A; Skills - writing, visual design (for slide materials), PowerPoint, communication, literature/curricular materials search (both within medical education and in other relevant fields), commitment to and interest in social justice, collaboration, organization | Emily Ruedinger, eruedinger@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc6MOWleQli2WyY97zo8jDzD1uGlmCSfy-vtR3odxK0fhgbRFjNeu0IYdcPf20z1Cw | |||||||||||
| 28/01/2022 | eruedinger@wisc.edu | Emily | Ruedinger | MD, MEd | Assistant Professor | Pediatrics | General Pediatrics and Adolescent Medicine | Developing an online course and portfolio to enhance pediatric residents’ learning about scholarly work | The UW Pediatrics Residency Program PUBLISH (Producing Understanding in the Basics of Literature, Inquiry, and Scholarship in Healthcare) Pathway is designed to build expertise in scholarly work through structured mentorship from experienced faculty, deep engagement in a project, introduction to core research principles, exposure to varied types of scholarship, and training in scholarly communication skills. Pediatric residents participate in this optional pathway through their 3 years of residency, attending supplementary lectures and an annual retreat, and completing relevant assignments, and engaging in mentored projects. This pathway is now in its second year of existence. | 1 | This is a curriculum development project. It will entail building an online Canvas course for PUBLISH materials, assignments, and resident ePortfolios using materials that have already been developed, as well as additional content that the student will curate and develop on key research topics (for example, introductory resources on survey design, writing scientific papers, and similar topics). The Canvas course will be an adjunct to in-person and virtual components of the pathway that have already been developed. The student does not need to be familiar with Canvas course design prior to this project, but must be interested in learning about this platform through the use of virtual resources and tutorials, have some existing proficiency in principles of web design, and be tech-savvy. To optimize both engagingness and ease-of-use for the course, the student will need to explore other online teaching tools (eg Flipgrid, PowToon, Prezi, Canva, Kahoot!, etc.), consider suitability for incorporation into the Canvas course, and (when appropriate) translate content using one or more of these learning tools. The student will need to create “user guides” for: (1) residents on how to create and export their ePortfolio; (2) course directors on how to revise course content on Canvas over time; and (3) PUBLISH faculty for any content transitioned to a novel online teaching tool, so that content can be revised as needed in the future. The student should assume resident and faculty users will have varying levels of tech-savviness. If desired, the student could help create an evaluation plan to understand how the online content impacts the resident experience on the PUBLISH pathway; this would require investment beyond the Shapiro project and interest in this could be determined toward the end of their Shapiro time. | writing, visual design, web design, technology, literature/curricular materials search, collaboration, organization | N/A | No | No (plan to use Dean's Office Funds) | Student will need access to computer and internet. Can use personal device or Division computer in our offices. | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | Yes | Bradley Kerr bkerr@wisc.edu; Christine Richards crichards9@wisc.edu | No | Developing an online course and portfolio to enhance pediatric residents’ learning about scholarly work: The UW Pediatrics Residency Program PUBLISH (Producing Understanding in the Basics of Literature, Inquiry, and Scholarship in Healthcare) Pathway is designed to build expertise in scholarly work through structured mentorship from experienced faculty, deep engagement in a project, introduction to core research principles, exposure to varied types of scholarship, and training in scholarly communication skills. Pediatric residents participate in this optional pathway through their 3 years of residency, attending supplementary lectures and an annual retreat, and completing relevant assignments, and engaging in mentored projects. This pathway is now in its second year of existence. ____________________________________________________________________________ Role - This is a curriculum development project. It will entail building an online Canvas course for PUBLISH materials, assignments, and resident ePortfolios using materials that have already been developed, as well as additional content that the student will curate and develop on key research topics (for example, introductory resources on survey design, writing scientific papers, and similar topics). The Canvas course will be an adjunct to in-person and virtual components of the pathway that have already been developed. The student does not need to be familiar with Canvas course design prior to this project, but must be interested in learning about this platform through the use of virtual resources and tutorials, have some existing proficiency in principles of web design, and be tech-savvy. To optimize both engagingness and ease-of-use for the course, the student will need to explore other online teaching tools (eg Flipgrid, PowToon, Prezi, Canva, Kahoot!, etc.), consider suitability for incorporation into the Canvas course, and (when appropriate) translate content using one or more of these learning tools. The student will need to create “user guides” for: (1) residents on how to create and export their ePortfolio; (2) course directors on how to revise course content on Canvas over time; and (3) PUBLISH faculty for any content transitioned to a novel online teaching tool, so that content can be revised as needed in the future. The student should assume resident and faculty users will have varying levels of tech-savviness. If desired, the student could help create an evaluation plan to understand how the online content impacts the resident experience on the PUBLISH pathway; this would require investment beyond the Shapiro project and interest in this could be determined toward the end of their Shapiro time. ; IRB Status - N/A; Skills - writing, visual design, web design, technology, literature/curricular materials search, collaboration, organization | Emily Ruedinger, eruedinger@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudzJ7ZXfH24FWVj_OaoldjArB_OA3oaurKdmIn7USnALOHaviGirj0SxBnW7KoHuEs | |||||||||||
| 07/12/2021 | kschaumberg@wisc.edu | Katherine | Schaumberg | PhD | Assistant Professor | 9.192.449.415 | Psychiatry | Development of a peer-led intervention to challenge anti-fat bias among health professional students | A growing body of evidence indicates that anti-fat bias contributes to poor health outcomes for individuals in larger bodies and significantly impacts healthcare access, quality, and equity. The long-term objectives of this work will be to develop an intervention which (1) reduces anti-fat bias and fatphobia among health professionals in both their personal and professional lives and (2) improves health professionals’ clinical competence in weight-related patient encounters. The current project will focus on defining the feasibility and acceptability of this intervention. Ultimately, this line of research will aim to develop and disseminate an evidence-based intervention to reduce anti-fat bias amongst the next generation of health care providers. Also opportunities for involvement in other studies in the lab related to risk for eating disorders in adolescents and the genetic epidemiology of eating disorders. lab website: embark.psychiatry.wisc.edu | 0 | Research Coordinator; Peer facilitator; Trainer | Moderate (will be integrated into the lab with regular mentorship but also work independentlY) | Some experience with statistical analysis and coding would be useful, but not required. We use R for statistical analyses | Approved | Yes | Yes | Yes | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Genetic Counseling students, MPH students, PhD students, UW undergraduates interested in research | Yes | Yes | Kayo Tada; kkern3@wisc.edu | Yes | Development of a peer-led intervention to challenge anti-fat bias among health professional students: A growing body of evidence indicates that anti-fat bias contributes to poor health outcomes for individuals in larger bodies and significantly impacts healthcare access, quality, and equity. The long-term objectives of this work will be to develop an intervention which (1) reduces anti-fat bias and fatphobia among health professionals in both their personal and professional lives and (2) improves health professionals’ clinical competence in weight-related patient encounters. The current project will focus on defining the feasibility and acceptability of this intervention. Ultimately, this line of research will aim to develop and disseminate an evidence-based intervention to reduce anti-fat bias amongst the next generation of health care providers. Also opportunities for involvement in other studies in the lab related to risk for eating disorders in adolescents and the genetic epidemiology of eating disorders. lab website: embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Research Coordinator; Peer facilitator; Trainer; IRB Status - Approved; Skills - Some experience with statistical analysis and coding would be useful, but not required. We use R for statistical analyses | Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor: | ||||||||||
| 07/12/2021 | lschnapp@medicine.wisc.edu | Lynn | Schnapp | MD | Professor, Chair of Medicine | 608 | Medicine | Pulmonary and Critical Care Medicine | Cell and Regenerative Biology | Carole Wilson, Research Associate Professor | cwilson@medicine.wisc.edu | Medicine | Pulmonary and Critical Care Medicine | Mechanisms in lung injury, inflammation and repair | Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn | 1 | The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab. | We can tailor the project to the student’s interests and aptitude. The student would work closely with lab personnel. | Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | n/a | Yes | Yes | Yes | Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity, Willing to work with interested students to develop an appropriate research experience | PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | 1. Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. Chest. 1;146(6):1543-53. 2014. PMC4251616 2. Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G. CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 308(8):L759-65. 2015 3. Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methe BA, Kaminski N, Sandhaus RA, GRADS Alpha-1 Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc. 12(10):1551-60. 2015. PMC4627425. *listed collaborator 4. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group*. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 12(10):1561-71 2015. PMID: 26193069. *listed collaborator 5. Gharib SA, Malur A, Huizar I, Barna BP, Kavuru MS, Schnapp LM*, Thomassen MJ*. Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 17(1):93. 2016 *Shared senior authorship. 6. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM*, Gharib SA*. Widespread activation of immunity and pro‐inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiological Reports. 4(8) pii: e12756. 2016. PMC4848721. *Shared senior authorship. 7. Attia EF, Jolley SE, Crothers K, Schnapp LM*, Liles WC*. Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS One. 11(2):e0149687. 2016 *Shared senior authorship. 8. Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM. Ablation of Pericyte-like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. Am J Respir Cell Mol Biol. 56(2):160-167 2017. PMC5359647. (Featured in “Red Alerts” highlighted articles) 9. Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA. Lung pericyte-like cells are functional immune sentinel cells. Am J Physiol Lung Cell Mol Physiol. 312(4): L556-L567. 2017. PMC5407093. (Chosen for “APSselect” highlight) 10. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Strange S, for QUANTUM-1 Investigators. Serum proteins associated with emphysema progression in severe alpha-1 antitrypsin deficiency. Chronic Obstr Pulm Dis. 4(3): 204-216. 2017 11. Mohan A, Malur A, McPeek M, Barna BP, Schnapp LM*, Thomassen MJ*, Gharib SA*. Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis. Am J Physiol Lung Cell Mol Physiol. 314(4):L617-L625, 2017. PMC5966779 *Shared senior authorship. 12. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV Infection on Alpha-1 Antitrypsin in the Lung. Am J Physiol Lung Cell Mol Physiol. 314(4):L583-L592. 2017. PMC5966776 13. Hung CF, Wilson CL, Chow YH, Schnapp LM. Role of integrin alpha8 in murine model of lung fibrosis. PLoS One. 13(5):e0197937. 2018. PMC5973593. 14. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 218(12):1995-2005, 2018. 15. Wilson CL, Stephenson SE, Higuero JP, Feghali-Bostwick C, Hung CF, Schnapp LM Characterization of human PDGFRβ-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18. doi: 10.1152/ajplung.00289.2018. PMID:30335500 16. Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group. The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. Am J Med Sci. 2019 May;357(5):405-410. PubMed PMID: 31010467. 17. Hung CF, Wilson CL, Schnapp LM. Pericytes in the Lung. Adv Exp Med Biol. 2019;1122:41-58. PubMed PMID: 30937862. 18. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest 2021. 19. Stephenson SE, Wilson CL, Bond NG, Kaur A, Alvarez X, Midkiff CC, Schnapp LM. Pericytes as novel targets for HIV/SIV infection in the lung. Am J Physiol Lung Cell Mol Physiol 2020; 319: L848-l853. 20. Mohan A, Neequaye N, Malur A, Soliman E, McPeek M, Leffler N, Ogburn D, Tokarz DA, Knudson W, Gharib SA, Schnapp LM, Barna BP, Thomassen MJ. Matrix Metalloproteinase-12 Is Required for Granuloma Progression. Front Immunol 2020; 11: 553949. | Yes | jewerndli@medicine.wisc.edu | Yes | Mechanisms in lung injury, inflammation and repair: Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn ____________________________________________________________________________ Role - The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab.; IRB Status - n/a; Skills - Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm. | Lynn Schnapp, lschnapp@medicine.wisc.edu -- Co-Mentor: Carole Wilson, Research Associate Professor cwilson@medicine.wisc.edu | ||||
| 19/01/2022 | kmschro1@wisc.edu | Kristopher | Schroeder | MD | Professor | 6.082.321.542 | Anesthesiology | Anesthesiology Research Project | Work with this group will be tailored to match the interests of the medical student. Possible options would be to expand upon the work completed by Myzewski in 2021 (see manuscript in Reg Anesth Pain Med) that evaluated the use of artificial intelligence and machine learning to summarize the published literature and evaluate the use of this tool outside of the field of anesthesiology. Other options might include a study of the education implications of the NerveBlox system that uses artificial intelligence to identify anatomic structures on ultrasound imaging. Finally, there are chart review projects evaluating changes in analgesic pathways/regional anesthesia techniques and anatomy studies that could be considered. | 2 | The students role would be (with the assistance/guidance of the faculty) to conceive of a study question, complete required IRB documentation, conduct the study, collect and analyze the data, and write an abstract/manuscript. | N/A | N/A | No | Yes | Yes | Shorter term projects, Research Electives for credit | UW undergraduates interested in research | Yes | Jeremy Sullivan - jasullivan@wisc.edu, Judy Helt - jhelt@wisc.edu, Mary Roth - maroth4@wisc.edu | No | Anesthesiology Research Project: Work with this group will be tailored to match the interests of the medical student. Possible options would be to expand upon the work completed by Myzewski in 2021 (see manuscript in Reg Anesth Pain Med) that evaluated the use of artificial intelligence and machine learning to summarize the published literature and evaluate the use of this tool outside of the field of anesthesiology. Other options might include a study of the education implications of the NerveBlox system that uses artificial intelligence to identify anatomic structures on ultrasound imaging. Finally, there are chart review projects evaluating changes in analgesic pathways/regional anesthesia techniques and anatomy studies that could be considered. ____________________________________________________________________________ Role - The students role would be (with the assistance/guidance of the faculty) to conceive of a study question, complete required IRB documentation, conduct the study, collect and analyze the data, and write an abstract/manuscript. ; IRB Status - N/A; Skills - N/A | Kristopher Schroeder, kmschro1@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc-6ecY0TkY8848v7l62HYCjq2jQkeJin1U0knYrKMmcir2N96OnYHKGilMeEK1zUY | |||||||||||
| 25/01/2022 | cseibert@wisc.edu | Christine | Seibert | MD | Associate Dean for Medical Student Services and Education | 608 | Academic Affairs | Medicine | Jason Stephenson | jwstephenson@wisc.edu | Academic Affairs | Radiology | Assessment and Planning for a More Inclusive and Antiracist HSLC Physical Space | When striving to become more anti-racist institution, it is important to assess and address the physical spaces where community members work, learn, study and relax. The White Coat 4 Black Lives (WCFBL) report card states that “physical space is one of the important elements of anti-racist institutions” and that medical schools should acknowledge the contributions of alumni and other physicians of color (through plaques, statues, portraits, and building names) while not celebrating racist or white supremacist individuals. Furthermore, medical schools must ensure that alumni of color, as well as patients and other people of color who have contributed to the advancement of medical science, are celebrated publicly. In the summer of 2021, a Shapiro-sponsored medical student did a thorough literature review researching how other institutions evaluate and create anti-racist spaces. A 12-question Qualtrics survey was created and shared with UWSMPH health professional students to gain insight into what makes a space anti-racist. Qualitative analysis informed a pilot tool with 20 yes/no items about structural, visual, and cultural aspects of the HSLC to do an assessment of the SMPH HSLC physical spaces. We are looking for a student to continue to pilot the current assessment tool in order to receive more feedback regarding usability and relevance of assessment tool content as well as expand the outreach of the survey to include HSLC faculty and staff perspectives. The goal would be to utilize expanded survey results to further refine the assessment tool to accurately assess a physical space’s degree of anti-racism and ultimately apply the results to make suggestions for positive change. | 0 | Student will have the unique opportunity to further previous foundational work regarding the assessment of medical education physical spaces as anti-racist and inclusive and make recommendations about how to make the HSLC a more anti-racist space. | Looking for a self-starter, able to work on and move a project forward with minimal supervision. | Organizational skills and data management. | NA | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | Yes | Elizabeth Tuschen etuschen@wisc.edu | Yes | Assessment and Planning for a More Inclusive and Antiracist HSLC Physical Space : When striving to become more anti-racist institution, it is important to assess and address the physical spaces where community members work, learn, study and relax. The White Coat 4 Black Lives (WCFBL) report card states that “physical space is one of the important elements of anti-racist institutions” and that medical schools should acknowledge the contributions of alumni and other physicians of color (through plaques, statues, portraits, and building names) while not celebrating racist or white supremacist individuals. Furthermore, medical schools must ensure that alumni of color, as well as patients and other people of color who have contributed to the advancement of medical science, are celebrated publicly. In the summer of 2021, a Shapiro-sponsored medical student did a thorough literature review researching how other institutions evaluate and create anti-racist spaces. A 12-question Qualtrics survey was created and shared with UWSMPH health professional students to gain insight into what makes a space anti-racist. Qualitative analysis informed a pilot tool with 20 yes/no items about structural, visual, and cultural aspects of the HSLC to do an assessment of the SMPH HSLC physical spaces. We are looking for a student to continue to pilot the current assessment tool in order to receive more feedback regarding usability and relevance of assessment tool content as well as expand the outreach of the survey to include HSLC faculty and staff perspectives. The goal would be to utilize expanded survey results to further refine the assessment tool to accurately assess a physical space’s degree of anti-racism and ultimately apply the results to make suggestions for positive change. ____________________________________________________________________________ Role - Student will have the unique opportunity to further previous foundational work regarding the assessment of medical education physical spaces as anti-racist and inclusive and make recommendations about how to make the HSLC a more anti-racist space. ; IRB Status - NA; Skills - Organizational skills and data management. | Christine Seibert, cseibert@wisc.edu -- Co-Mentor: Jason Stephenson jwstephenson@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufs09N9FBa_Vk7GL_8R3Hura_usjNlmv68QDT-dkHpV75xB2e16fxMcRE9ykH46rw0 | |||||
| 18/01/2022 | vsetaluri@dermatology.wisc.edu | Vijay | Setaluri | PhD | Professor | 608 | Dermatology | Jose Ayuso | ayusodomingu@wisc.edu | Dermatology | Effect of Skin Cytokine Milieu on Melanoma Tumor Development | Oncogenic mutations that cause melanoma skin cancer have been identified. However, acquiring these mutations is not sufficient for melanoma cancer initiation because after an initial burst of cell proliferation, these mutations cause growth arrest (also known as OIS, oncogene induced senescence) of the transformed melanocytes. OIS is thought to serve as a defense mechanism to prevent runaway cell proliferation. It is believed that escape from senescence is a prerequisite for melanoma development. Additional genetic events such as loss of tumor suppressor and/or epigenetic changes that occur within the melanocytes and facilitate senescence evasion have been studied in detail. On the other hand, the role of the skin microenvironment, especially the role of factors secreted by the epidermal keratinocytes on melanomagenesis, is not completely understood. In the work completed by a previous Shapiro student, we employed White Caucasian and black, African American keratinocytes to investigate the role of keratinocyte derived factors on OIS in oncogene-transformed melanocytes.This work has identified Vascular Endothelial Growth Factor (VEGF-A) and other factors as a potential determinant of melanoma development. In this project, we will test the role and mechanism of action of VEGF-A in melanomagenesis. | 1 | The student will participate in ongoing research that is aimed at understanding the initial events in melanoma skin cancer development. The student will be involved in culturing normal human skin cells, working with microdevices, preparation of cells for morphological analysis including fluorescence microscopy and molecular studies such as RT-PCT. | Medium | Basic laboratory skills such as pipetting etc.preferred but not required | N/A | Yes | Departmental funds | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | PhD students, UW undergraduates interested in research | No | Mary Poellinger |
No | Effect of Skin Cytokine Milieu on Melanoma Tumor Development: Oncogenic mutations that cause melanoma skin cancer have been identified. However, acquiring these mutations is not sufficient for melanoma cancer initiation because after an initial burst of cell proliferation, these mutations cause growth arrest (also known as OIS, oncogene induced senescence) of the transformed melanocytes. OIS is thought to serve as a defense mechanism to prevent runaway cell proliferation. It is believed that escape from senescence is a prerequisite for melanoma development. Additional genetic events such as loss of tumor suppressor and/or epigenetic changes that occur within the melanocytes and facilitate senescence evasion have been studied in detail. On the other hand, the role of the skin microenvironment, especially the role of factors secreted by the epidermal keratinocytes on melanomagenesis, is not completely understood. In the work completed by a previous Shapiro student, we employed White Caucasian and black, African American keratinocytes to investigate the role of keratinocyte derived factors on OIS in oncogene-transformed melanocytes.This work has identified Vascular Endothelial Growth Factor (VEGF-A) and other factors as a potential determinant of melanoma development. In this project, we will test the role and mechanism of action of VEGF-A in melanomagenesis. ____________________________________________________________________________ Role - The student will participate in ongoing research that is aimed at understanding the initial events in melanoma skin cancer development. The student will be involved in culturing normal human skin cells, working with microdevices, preparation of cells for morphological analysis including fluorescence microscopy and molecular studies such as RT-PCT. ; IRB Status - N/A; Skills - Basic laboratory skills such as pipetting etc.preferred but not required | Vijay Setaluri, vsetaluri@dermatology.wisc.edu -- Co-Mentor: Jose Ayuso ayusodomingu@wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf1YeInK_zN8BLrdkkCMVbxoI-9qwPJPuJ-JwvmaGxr1-evsLw8mU50MqDgcjnzfGU | |||||||
| 15/12/2021 | kshadman@wisc.edu | Kristin | Shadman | MD | Associate Professor of Pediatrics | 6.082.658.561 | Pediatrics | Hospital Medicine | Factors influencing feeding decisions in children with bronchiolitis receiving HFNC support | Background. Bronchiolitis is the most common cause of hospitalizations among infants in the first 12 months of life and common in children up to 24 months of age. As a patient’s respiratory distress worsens, the ability to effectively feed and stay hydrated may similarly worsen due to the difficulty in sucking, swallowing, and breathing in coordination with faster, more labored respiratory effort. High flow nasal cannula (HFNC) is a method of delivering heated, humidified air with increased flows of oxygen to patients with bronchiolitis, which is thought to improve work of breathing, reduce rates of intubation, and reduce the likelihood of PICU admission. The goal of the feeding plan during HFNC therapy is to balance the nutritional benefits of oral feeding with the occurrence of feeding related adverse events, such as aspiration. Currently, HFNC is associated with the longest nil per os (NPO) time of any respiratory support modality. While early oral feeding during HFNC is associated with shorter LOS without increase aspiration pneumonia or intubation, substantial variation in feeding practices still exist within and between institutions. Decisions regarding when and how to feed a child on HFNC may be influenced by many different perspectives, including those of parents, bedside nurses, speech therapists, and resident, hospitalist and critical care physicians. Purpose: The purpose of this study is to identify the drivers of feeding practices during HFNC to inform future local and national quality improvement interventions to minimize NPO time and reduce variation in feeding practices for children with bronchiolitis. Aim. Identify the drivers of feeding timing and delivery for children with bronchiolitis on HFNC from interviews of interdisciplinary team members. | 1 | The student's primary role will be in assisting with coding and analyzing the qualitative data from interviews of a interdisciplinary group of experts from around the country. There is also opportunity to learn about implementation and dissemination of best practices based on our results using quality improvement methods. The student will work closely with the mentor, as well as one of our research methods, and learn to use Dedoose, which is a common software used to in coding qualitative interviews. | The student needs to be able to independently work on coding transcripts, once they are fully trained, however there is be plenty of opportunity for collaboration and mentorship in those skills. | Ability to do a relevant literature review | Has not yet been submitted, however will be minimal risk submission. | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Kim Stevenson | Yes | Factors influencing feeding decisions in children with bronchiolitis receiving HFNC support: Background. Bronchiolitis is the most common cause of hospitalizations among infants in the first 12 months of life and common in children up to 24 months of age. As a patient’s respiratory distress worsens, the ability to effectively feed and stay hydrated may similarly worsen due to the difficulty in sucking, swallowing, and breathing in coordination with faster, more labored respiratory effort. High flow nasal cannula (HFNC) is a method of delivering heated, humidified air with increased flows of oxygen to patients with bronchiolitis, which is thought to improve work of breathing, reduce rates of intubation, and reduce the likelihood of PICU admission. The goal of the feeding plan during HFNC therapy is to balance the nutritional benefits of oral feeding with the occurrence of feeding related adverse events, such as aspiration. Currently, HFNC is associated with the longest nil per os (NPO) time of any respiratory support modality. While early oral feeding during HFNC is associated with shorter LOS without increase aspiration pneumonia or intubation, substantial variation in feeding practices still exist within and between institutions. Decisions regarding when and how to feed a child on HFNC may be influenced by many different perspectives, including those of parents, bedside nurses, speech therapists, and resident, hospitalist and critical care physicians. Purpose: The purpose of this study is to identify the drivers of feeding practices during HFNC to inform future local and national quality improvement interventions to minimize NPO time and reduce variation in feeding practices for children with bronchiolitis. Aim. Identify the drivers of feeding timing and delivery for children with bronchiolitis on HFNC from interviews of interdisciplinary team members. ____________________________________________________________________________ Role - The student's primary role will be in assisting with coding and analyzing the qualitative data from interviews of a interdisciplinary group of experts from around the country. There is also opportunity to learn about implementation and dissemination of best practices based on our results using quality improvement methods. The student will work closely with the mentor, as well as one of our research methods, and learn to use Dedoose, which is a common software used to in coding qualitative interviews.; IRB Status - Has not yet been submitted, however will be minimal risk submission. ; Skills - Ability to do a relevant literature review | Kristin Shadman, kshadman@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuePk0NM7jh521wHcb0A4Z0AOtzIgKDQTGzcvyT998PbSzjYhQHCipOIU3mL3Q6o_8Q | |||||||||
| 19/12/2021 | ddshapiro@wisc.edu | Daniel | Shapiro | M.D. | Assistant Professor | Urology | Partial nephrectomy outcomes among high-risk surgical candidates | Dr. Shapiro conducts clinical and translational research focusing on urologic malignancies, particularly kidney cancer. Research projects currently include, but are not limited to, evaluating surgical and oncologic outcomes of patients undergoing partial nephrectomy who are high risk surgical candidates as well as evaluating renal cell carcinoma tumor immune microenvironment signatures. We are additionally establishing VA outcomes databases for urologic malignancies with plans to evaluate GU oncologic care within this specific population. Research projects can be specifically tailored toward the student’s interests. The goal of the research is to allow the student to complete a high quality research project in a timely fashion, submit abstracts and present results at academic conferences, and become a primary author on scientific publications. Additional benefits would include opportunities for career mentorship, ability to shadow in the operating room, and the chance to learn if urology/surgery is a potential career path the student would like to pursue. The only requirements for the students are enthusiasm and a strong work ethic. | 0 | Data collection, analysis (with statistician), writing, presenting | Enthusiasm, strong work ethic, some statistical knowledge is helpful | approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects | Not currently available to mentor other students | No | ddshapiro@wisc.edu | No | Partial nephrectomy outcomes among high-risk surgical candidates: Dr. Shapiro conducts clinical and translational research focusing on urologic malignancies, particularly kidney cancer. Research projects currently include, but are not limited to, evaluating surgical and oncologic outcomes of patients undergoing partial nephrectomy who are high risk surgical candidates as well as evaluating renal cell carcinoma tumor immune microenvironment signatures. We are additionally establishing VA outcomes databases for urologic malignancies with plans to evaluate GU oncologic care within this specific population. Research projects can be specifically tailored toward the student’s interests. The goal of the research is to allow the student to complete a high quality research project in a timely fashion, submit abstracts and present results at academic conferences, and become a primary author on scientific publications. Additional benefits would include opportunities for career mentorship, ability to shadow in the operating room, and the chance to learn if urology/surgery is a potential career path the student would like to pursue. The only requirements for the students are enthusiasm and a strong work ethic. ____________________________________________________________________________ Role - Data collection, analysis (with statistician), writing, presenting; IRB Status - approved; Skills - Enthusiasm, strong work ethic, some statistical knowledge is helpful | Daniel Shapiro, ddshapiro@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuenrL-OOtIj9R9FrYui1-r-5MLOU3bpbtwtccJlVgAWNuYZzAjuQGLZyMU30qyRgjU | ||||||||||||
| 29/12/2021 | tsingh@medicine.wisc.edu | Tripti | Singh | MD | Defining kidney biopsy findings in kidney autotransplant patients with LPHS | 4.128.770.852 | Medicine | Nephrology | Defining kidney biopsy findings in kidney autotransplant patients with LPHS | Loin Pain Hematuria Syndrome is a very rare disease associated with hematuria and severe life debilitating flank pain. Majority of patients with LPHS are on chronic opioids for pain control and still have a poor quality of life due to chronic pain. Pathogenesis of LPHS is not known currently. Auto-transplant is one of the treatment used for pain control where patient's kidney is removed from the retroperitoneal space and transplanted to their own flank. This has been shown to decrease the pain and improve quality of life in patients with LPHS. UW health is the major center in the world with maximum number of auto-transplants done per year for LPHS. (https://www.uwhealth.org/treatments/renal-autotransplant) We have intra-operative kidney biopsy in LPHS patients. The goal of this project to see if there are specific kidney biopsy findings in patients with LPHS and if kidney biopsy findings are related to pain. | 1 | 1. Do literature search about kidney biopsy findings in patients with LPHS 2. Extract data about kidney biopsy from EHR in patients with LPHS who have had kidney biopsy 3. Work with statistician in DOM to analyze the results. | Literature search in Pubmed and working with excel. | Approved already | No | No (plan to use Dean's Office Funds) | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Audrey Nelson | No | Defining kidney biopsy findings in kidney autotransplant patients with LPHS: Loin Pain Hematuria Syndrome is a very rare disease associated with hematuria and severe life debilitating flank pain. Majority of patients with LPHS are on chronic opioids for pain control and still have a poor quality of life due to chronic pain. Pathogenesis of LPHS is not known currently. Auto-transplant is one of the treatment used for pain control where patient's kidney is removed from the retroperitoneal space and transplanted to their own flank. This has been shown to decrease the pain and improve quality of life in patients with LPHS. UW health is the major center in the world with maximum number of auto-transplants done per year for LPHS. (https://www.uwhealth.org/treatments/renal-autotransplant) We have intra-operative kidney biopsy in LPHS patients. The goal of this project to see if there are specific kidney biopsy findings in patients with LPHS and if kidney biopsy findings are related to pain. ____________________________________________________________________________ Role - 1. Do literature search about kidney biopsy findings in patients with LPHS 2. Extract data about kidney biopsy from EHR in patients with LPHS who have had kidney biopsy 3. Work with statistician in DOM to analyze the results. ; IRB Status - Approved already; Skills - Literature search in Pubmed and working with excel. | Tripti Singh, tsingh@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueIxZCmsqkcblrmfn8MVRmrsLt_iar9hdJbK9Zbx4s8B8WJaS-rNnWiMfJTq2MLPR4 | ||||||||||
| 10/12/2021 | rjspencer2@wisc.edu | Ryan | Spencer | MD, MS | Associate Professor OB/GYN | 631 | Obstetrics & Gynecology | Gynecologic Oncology | Rural clinical experiences in OBGYN Residency Training | Two important principles known in graduate medical education (GME) are: 1) those with rural experiences are 3 times more likely to practice in rural locations; 2) residents are more likely to practice within 60 minutes of their residency location than outside. This project will investigate the rural experiences offered to all OBGYN residency programs in the country to identify what percentage of time and percentage of OBGYN residents are exposed to rural clinical experiences. The project will work with residency program coordinators around the country to identify the location of clinical rotations during OBGYN residency. | 0 | The Shapiro student will take charge of data collection, documentation, and liaison with program coordinators. The student will take part in data analysis and construction of abstract submission for scientific/clinical meetings as well as applicable manuscript preparation. | This project will have close oversight but will also require independent data collection. | REDCAP preferred although not required. | Will be exempt as will not involve human subjects. | No | Yes | Yes | Research Electives for credit | Not currently available to mentor other students | Yes | Yes | Andrea Zorbas (zorbas@wisc.edu) | Yes | Rural clinical experiences in OBGYN Residency Training: Two important principles known in graduate medical education (GME) are: 1) those with rural experiences are 3 times more likely to practice in rural locations; 2) residents are more likely to practice within 60 minutes of their residency location than outside. This project will investigate the rural experiences offered to all OBGYN residency programs in the country to identify what percentage of time and percentage of OBGYN residents are exposed to rural clinical experiences. The project will work with residency program coordinators around the country to identify the location of clinical rotations during OBGYN residency. ____________________________________________________________________________ Role - The Shapiro student will take charge of data collection, documentation, and liaison with program coordinators. The student will take part in data analysis and construction of abstract submission for scientific/clinical meetings as well as applicable manuscript preparation.; IRB Status - Will be exempt as will not involve human subjects.; Skills - REDCAP preferred although not required. | Ryan Spencer, rjspencer2@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueIVpYulz1SHmszrzUfri-PtPC7ZbhUlJ2QtcL_kDy0IxbaInYcp9h9Ds1-8yJb8Po | ||||||||
| 20/01/2022 | spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor | 6.082.635.626 | Orthopedics and Rehabilitation | Sports Medicine | Patient Reported Outcome Measures – how do patient answers compare across multiple patient reported outcomes in hip preservation? | We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. This particular project will involve collaboration with a hip preservation surgeon and research team at UCSF. Our specific project involves a retrospective review of patient reported outcomes collected from patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS). Patients who have hip preservation surgery (hip arthroscopy and periacetabular osteotomy) are all prospectively enrolled in the UW hip preservation registry. Outcome scores are collected electronically, and patient complete multiple different patient reported outcome measures (including scores such as the modified Harris Hip Score, the Hip Outcome Score – Sport Specific and Activities of Daily Living, the SANE score and the international Hip Outcome Tool). The goal of this study will be to compare these individual scores, identify areas of crossover, and then determine if the patients’ answers to similar questions are also similar. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | : IRB approval for our registry; exemption application will be submitted in January | No | Yes | Yes | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Not currently available to mentor other students | Unsure / Depends | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator | Unsure / Depends | Patient Reported Outcome Measures – how do patient answers compare across multiple patient reported outcomes in hip preservation?: We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. This particular project will involve collaboration with a hip preservation surgeon and research team at UCSF. Our specific project involves a retrospective review of patient reported outcomes collected from patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS). Patients who have hip preservation surgery (hip arthroscopy and periacetabular osteotomy) are all prospectively enrolled in the UW hip preservation registry. Outcome scores are collected electronically, and patient complete multiple different patient reported outcome measures (including scores such as the modified Harris Hip Score, the Hip Outcome Score – Sport Specific and Activities of Daily Living, the SANE score and the international Hip Outcome Tool). The goal of this study will be to compare these individual scores, identify areas of crossover, and then determine if the patients’ answers to similar questions are also similar. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - : IRB approval for our registry; exemption application will be submitted in January; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueWj2exNBMevQb2atujs3Mvi0IeQpMfPlDljlmeYxKP9PVR06XCdsRpNAKHtOXcvko | |||||||||
| 20/01/2022 | spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, UW Hip Preservation Program; Program Director, UW Sports Medicine Fellowship | 6.082.635.626 | Orthopedics and Rehabilitation | Sports Medicine | Bibliometric Review of Hip Preservation Literature | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study related to the field of hip preservation. This summer research project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. The student will be involved with this registry, but in addition, will work on writing a manuscript on the bibliometric review of hip preservation literature. This specific project will be patterned after the following study: Nayar SK, Dein EJ, Spiker AM, Bernard JA, Zikria BA. The Top 100 Cited Articles in Clinical Orthopedic Sports Medicine. Am J Orthop (Belle Mead NJ). 2015 Aug;44(8):E252-61. This will allow the student to finish the summer with at least one publication, and potentially more, depending on how productive we are with the prospective registry in addition to our bibliometric review. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | N/A for individual project. IRB approval completed for registry project. | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator | No | Bibliometric Review of Hip Preservation Literature: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study related to the field of hip preservation. This summer research project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. The student will be involved with this registry, but in addition, will work on writing a manuscript on the bibliometric review of hip preservation literature. This specific project will be patterned after the following study: Nayar SK, Dein EJ, Spiker AM, Bernard JA, Zikria BA. The Top 100 Cited Articles in Clinical Orthopedic Sports Medicine. Am J Orthop (Belle Mead NJ). 2015 Aug;44(8):E252-61. This will allow the student to finish the summer with at least one publication, and potentially more, depending on how productive we are with the prospective registry in addition to our bibliometric review. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - N/A for individual project. IRB approval completed for registry project.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudf0g9nwp2PuUa0qoLrahsZXEdrQYYw0yKTg_oV6XECoJmsKbJvo5cCpRy0QmSIwxs | |||||||||
| 18/01/2022 | spiker@ortho.wisc.edu | Andrea | Spiker | M.D. | Assistant Professor, Orthopedic Surgery; Director, UW Hip Preservation Program; Program Director, UW Sports Medicine Fellowship | 6.082.635.626 | Orthopedics and Rehabilitation | Sports Medicine | Opioid use in Hip Preservation Patients | We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. Preoperative opioid use for all patients will be cross referenced against patient reported outcome scores at both baseline and post-operative time points. Additionally, a subset of patients filled out a post-operative pain medication ‘diary’ which we will use for this specific project, in determining the average dosage and duration of pain medications for each procedure, and implement an immediate evidence based change in opioid prescribing practices within hip preservation at UW. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. | 0 | A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. | Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience. | Excel and Word. Organizational skills and good communication with the other members of the team. | IRB approval already obtained. | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Names of key staff in my department who will need to know about Shapiro Student: Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator | No | Opioid use in Hip Preservation Patients: We would like to involve a summer research student in our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of a prospectively collected patient reported outcomes registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of all patients who have undergone hip arthroscopy for femoroacetabular impingement syndrome (FAIS) and periacetabular osteotomy (PAO) for hip dysplasia and who were prospectively enrolled in our hip preservation registry. Preoperative opioid use for all patients will be cross referenced against patient reported outcome scores at both baseline and post-operative time points. Additionally, a subset of patients filled out a post-operative pain medication ‘diary’ which we will use for this specific project, in determining the average dosage and duration of pain medications for each procedure, and implement an immediate evidence based change in opioid prescribing practices within hip preservation at UW. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine, hip arthroscopy and periacetabular osteotomy) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A portion of the student’s time would be dedicated to entering patient data into the Hip Preservation Registry, obtained through a medical record chart review. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student may additionally be paired with a resident and will work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB approval already obtained.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. | Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucAAZ42sA0wBbLcNmknE7NfEYCA2rWaqjGHxP3GJVGUOUVyfXvQxai2E674RehGQxU | |||||||||
| 14/01/2022 | cthiessen@wisc.edu | Carrie | Thiessen | MD, PHD | Assistant Professor | 608 | Surgery | Transplant | Social support and psychosocial factors impact on outcomes for liver and kidney transplant recipients | Patients with end-stage liver and end-stage kidney disease undergo extensive medical and psychosocial evaluations that determine whether they are eligible for a transplant. The psychosocial assessment includes multiple factors, including social support, prior and current drug and alcohol use, mental health, adherence to previous medical care recommendations, and financial considerations. Some researchers have argued that excluding patients from transplant eligibility on the basis of high psychosocial risk factors unfairly disadvantages those who are already the worst off. Those who support the use of psychosocial risk assessment as a criterion for transplant eligibility argue that these factors affect the outcomes for the recipient and that transplant professionals have an obligation to be good stewards of scarce resources (donated organs). We are performing a retrospective, single-center chart review to determine if psychosocial support correlates with transplant recipient outcomes and adherence to post-transplant medical care. The University of Wisconsin transplant social work completes the Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) tool for every patient at their in-person transplant evaluation visit. We will determine if these scores correlate with transplant organ rejection, organ survival, patient survival, post-transplant hospitalizations, post-operative psychosocial disruptions, and non-adherence to medications. | 0 | Participating in the project will teach you key information about kidney and liver transplant surgery and transplant outcomes. You perform a literature review on psychosocial risk assessment in transplant. You will work with the team (including transplant fellows) to complete medical chart reviews for patients included in the study sample. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some evaluation appointments in the transplant clinic and committee meetings at which transplant eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once a week. | High | No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Approved | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | damico@surgery.wisc.edu | Unsure / Depends | Social support and psychosocial factors impact on outcomes for liver and kidney transplant recipients: Patients with end-stage liver and end-stage kidney disease undergo extensive medical and psychosocial evaluations that determine whether they are eligible for a transplant. The psychosocial assessment includes multiple factors, including social support, prior and current drug and alcohol use, mental health, adherence to previous medical care recommendations, and financial considerations. Some researchers have argued that excluding patients from transplant eligibility on the basis of high psychosocial risk factors unfairly disadvantages those who are already the worst off. Those who support the use of psychosocial risk assessment as a criterion for transplant eligibility argue that these factors affect the outcomes for the recipient and that transplant professionals have an obligation to be good stewards of scarce resources (donated organs). We are performing a retrospective, single-center chart review to determine if psychosocial support correlates with transplant recipient outcomes and adherence to post-transplant medical care. The University of Wisconsin transplant social work completes the Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) tool for every patient at their in-person transplant evaluation visit. We will determine if these scores correlate with transplant organ rejection, organ survival, patient survival, post-transplant hospitalizations, post-operative psychosocial disruptions, and non-adherence to medications. ____________________________________________________________________________ Role - Participating in the project will teach you key information about kidney and liver transplant surgery and transplant outcomes. You perform a literature review on psychosocial risk assessment in transplant. You will work with the team (including transplant fellows) to complete medical chart reviews for patients included in the study sample. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some evaluation appointments in the transplant clinic and committee meetings at which transplant eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once a week.; IRB Status - Approved; Skills - No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Carrie Thiessen, cthiessen@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuccH9OARd1Bzxy6I453MBM15SULTWPNXy8gTadr22v4_vsIONJbxsldXR71rQjSKXA | |||||||||
| 03/02/2022 | cthiessen@wisc.edu | Carrie | Thiessen | MD, PHD | Assistant professor | 608 | Surgery | Transplant | Ethical issues in living kidney donation | For patients with end-stage renal disease, transplantation with a kidney from a living donor is the best option. Individuals interested in donating to a friend or family member undergo an extensive medical and psychosocial evaluation to determine their eligibility to donate. In some cases, someone can give a kidney directly to their intended recipient. In other cases, they must donate via an exchange program: their kidney is transplanted into another patient with end-stage renal disease, and their intended recipient receives a kidney from another donor. Living donation poses risks to the donor and raises ethical questions about autonomy, informed consent, and shared-decision making. Multiple psychosocial issues are relevant as well. For example, how does donation or a decision not to donate on a donor’s relationship with their intended recipient? We previously conducted a prospective, multi-center study of 307 potential living kidney donors to assess their willingness to accept donation-related risks and evaluate their decision-making process. We are in the process of analyzing survey data and qualitative interviews. You would be able to choose one of the following topics to focus on during your research time: - Attitudes toward living donor kidney exchange programs - Preferences about the use of non-specific excuses (also known as alibis) for individuals who decide not to donate - Unmet support needs during evaluation or after donation - Financial burdens related to donation and coping mechanisms | 0 | Participating in the project will teach you about living kidney donation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some living kidney donor evaluations in the transplant clinic and committee meetings at which living kidney donor eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once or twice a week. | High | No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Approved | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | damico@surgery.wisc.edu | Unsure / Depends | Ethical issues in living kidney donation: For patients with end-stage renal disease, transplantation with a kidney from a living donor is the best option. Individuals interested in donating to a friend or family member undergo an extensive medical and psychosocial evaluation to determine their eligibility to donate. In some cases, someone can give a kidney directly to their intended recipient. In other cases, they must donate via an exchange program: their kidney is transplanted into another patient with end-stage renal disease, and their intended recipient receives a kidney from another donor. Living donation poses risks to the donor and raises ethical questions about autonomy, informed consent, and shared-decision making. Multiple psychosocial issues are relevant as well. For example, how does donation or a decision not to donate on a donor’s relationship with their intended recipient? We previously conducted a prospective, multi-center study of 307 potential living kidney donors to assess their willingness to accept donation-related risks and evaluate their decision-making process. We are in the process of analyzing survey data and qualitative interviews. You would be able to choose one of the following topics to focus on during your research time: - Attitudes toward living donor kidney exchange programs - Preferences about the use of non-specific excuses (also known as alibis) for individuals who decide not to donate - Unmet support needs during evaluation or after donation - Financial burdens related to donation and coping mechanisms ____________________________________________________________________________ Role - Participating in the project will teach you about living kidney donation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some living kidney donor evaluations in the transplant clinic and committee meetings at which living kidney donor eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once or twice a week.; IRB Status - Approved; Skills - No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Carrie Thiessen, cthiessen@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucHtw2wmjaer31rtlXxzYbpq_eUqqWxdaY6YIVp3STy5gos8ZZJmM56WhEjWHSP0sg | |||||||||
| 15/01/2022 | cthiessen@wisc.edu | Carrie | Thiessen | MD, PhD | Assistant Professor | 608 | Surgery | Transplant | Ethical issues in living kidney donation | For patients with end-stage renal disease, transplantation with a kidney from a living donor is the best option. Individuals interested in donating to a friend or family member undergo an extensive medical and psychosocial evaluation to determine their eligibility to donate. In some cases, someone can give a kidney directly to their intended recipient. In other cases, they must donate via an exchange program: their kidney is transplanted into another patient with end-stage renal disease, and their intended recipient receives a kidney from another donor. Living donation poses risks to the donor and raises ethical questions about autonomy, informed consent, and shared-decision making. Multiple psychosocial issues are relevant as well. For example, how does donation or a decision not to donate on a donor’s relationship with their intended recipient? We previously conducted a prospective, multi-center study of 307 potential living kidney donors to assess their willingness to accept donation-related risks and evaluate their decision-making process. We are in the process of analyzing survey data and qualitative interviews. You would be able to choose one of the following topics to focus on during your research time: - Attitudes toward living donor kidney exchange programs - Preferences about the use of non-specific excuses (also known as alibis) for individuals who decide not to donate - Unmet support needs during evaluation or after donation - Financial burdens related to donation and coping mechanisms | 0 | Participating in the project will teach you about living kidney donation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some living kidney donor evaluations in the transplant clinic and committee meetings at which living kidney donor eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once or twice a week. | High | No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Approved | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | damico@surgery.wisc.edu | Unsure / Depends | Ethical issues in living kidney donation: For patients with end-stage renal disease, transplantation with a kidney from a living donor is the best option. Individuals interested in donating to a friend or family member undergo an extensive medical and psychosocial evaluation to determine their eligibility to donate. In some cases, someone can give a kidney directly to their intended recipient. In other cases, they must donate via an exchange program: their kidney is transplanted into another patient with end-stage renal disease, and their intended recipient receives a kidney from another donor. Living donation poses risks to the donor and raises ethical questions about autonomy, informed consent, and shared-decision making. Multiple psychosocial issues are relevant as well. For example, how does donation or a decision not to donate on a donor’s relationship with their intended recipient? We previously conducted a prospective, multi-center study of 307 potential living kidney donors to assess their willingness to accept donation-related risks and evaluate their decision-making process. We are in the process of analyzing survey data and qualitative interviews. You would be able to choose one of the following topics to focus on during your research time: - Attitudes toward living donor kidney exchange programs - Preferences about the use of non-specific excuses (also known as alibis) for individuals who decide not to donate - Unmet support needs during evaluation or after donation - Financial burdens related to donation and coping mechanisms ____________________________________________________________________________ Role - Participating in the project will teach you about living kidney donation. You will perform a literature review relevant to your selected topic. You will learn how to analyze qualitative data using NVivo software. You will learn how to interpret the results of the data analysis. You will learn how to write and submit an abstract to a national conference (as the first author). If you are interested, you can participate as a co-author in helping to write the final results for submission to journals for publication. To help you understand the context of your research, you will attend some living kidney donor evaluations in the transplant clinic and committee meetings at which living kidney donor eligibility decisions are made. If you are interested, you may also observe transplant morbidity and mortality conferences, transplant patient rounds, and donor or transplant surgeries. You will be expected to participate in research team meetings once a week and weekly individual meetings with your mentor. Depending on team availability, you may be asked to attend evening meetings once or twice a week.; IRB Status - Approved; Skills - No prior knowledge of transplant or previous experience with abstract submission/manuscript writing is required. The idea student is detail-oriented, willing to ask questions when encountering unfamiliar information, good working on a team, and flexible with last-minute scheduling changes (sorry, that is just the nature of transplant). | Carrie Thiessen, cthiessen@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf_gqRaUT8u-p73bdHQ1KIYyU7aD-ka-NHfMXuR_SFAJRLC7Y8y2k2d651YEKlLB68 | |||||||||
| 29/11/2021 | gtoia@uwhealth.org | Giuseppe | Toia | MD, MS | Assistant Professor of Radiology | Radiology | Abdominal Imaging and Intervention | Radiology | Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Pneumoperitoneum | The objective of this study is to characterize the institutional diagnostic accuracy of a commercially available, FDA-cleared artificial intelligence decision support system (AIDOC) in diagnosing pneumoperitoneum on CT scans and to assess potential generalizability by conducting a failure mode analysis. A combination of increased scan volumes, imaging utilization, and need for timely radiology reports particularly in the acute setting has strained radiologists' capability to maintain diagnostic accuracy. Recently artificial intelligence (AI) decision support systems (DSS) have been developed to assist in maintaining diagnostic accuracy. Numerous AI algorithms exist, all with their own caveats and variability. AIDOC is a widely used commercially available, and FDA-cleared AI DSS. The AIDOC Free Air algorithm theoretically should assist in accurately diagnosing pneumoperitoneum. To date, there are no studies which investigate the diagnostic accuracy of AIDOC in the assessment of pneumoperitoneum. The aim of this study is to determine the diagnostic accuracy of detecting pneumoperitoneum at our institution. A failure mode analysis of potential reasons for misclassification will be performed. | 0 | Data collection, data analysis, abstract preparation, manuscript preparation | Excel, Word, basic statistics (SPSS or R is a plus!) | Submitted and in review | No | No (plan to use Dean's Office Funds) | Student will need access to radiology PACS system. If student does not have a work computer, student can use my office computer for any image analysis. | Shorter term projects | UW undergraduates interested in research | Voter AF et al. Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Intracranial Hemorrhage. J Am Coll Radiol 2021;18:1143-1152 Voter AF et al. Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Cervical Spine Fractures. AJNR Am J Neuroradiol 42:1550-56 | No | Kristyn Robicheau (krobicheau@uwhealth.org) - Admin Assistant | No | Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Pneumoperitoneum: The objective of this study is to characterize the institutional diagnostic accuracy of a commercially available, FDA-cleared artificial intelligence decision support system (AIDOC) in diagnosing pneumoperitoneum on CT scans and to assess potential generalizability by conducting a failure mode analysis. A combination of increased scan volumes, imaging utilization, and need for timely radiology reports particularly in the acute setting has strained radiologists' capability to maintain diagnostic accuracy. Recently artificial intelligence (AI) decision support systems (DSS) have been developed to assist in maintaining diagnostic accuracy. Numerous AI algorithms exist, all with their own caveats and variability. AIDOC is a widely used commercially available, and FDA-cleared AI DSS. The AIDOC Free Air algorithm theoretically should assist in accurately diagnosing pneumoperitoneum. To date, there are no studies which investigate the diagnostic accuracy of AIDOC in the assessment of pneumoperitoneum. The aim of this study is to determine the diagnostic accuracy of detecting pneumoperitoneum at our institution. A failure mode analysis of potential reasons for misclassification will be performed. ____________________________________________________________________________ Role - Data collection, data analysis, abstract preparation, manuscript preparation; IRB Status - Submitted and in review; Skills - Excel, Word, basic statistics (SPSS or R is a plus!) | Giuseppe Toia, gtoia@uwhealth.org -- Co-Mentor: | ||||||||||
| 25/01/2022 | rtsuchida@medicine.wisc.edu | Ryan | Tsuchida | MD | Dr. | Emergency Medicine | Exploring individual characteristics and job descriptions of Emergency Medicine Diversity, Equity, and Inclusion Leaders | Over the last few years, departments of EM have begun to approach DEI in a more systematic and holistic approach and have formed leaders dedicated to running DEI committees and, on occasion, appointing Vice-Chairs of DEI. Given the recent expansion in this structural approach, the specific roles and titles are not well described in the literature. This project is a self-reported electronically distributed survey designed to better understand the current landscape of DEI leaders in emergency medicine. We will reach out to academic institutions across the United States to identify who, if anyone, in the department is a DEI department lead and report details of their job description. | 0 | Data collection and analysis. Manuscript preparation (literature review, writing) | None, there is some special software involved (Qualtrics) which is easy to learn and I can teach to any student. | Under departmental review (formal IRB to follow) | No | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | Dr. Manish Shah, mnshah@medicine.wisc.edu | Yes | Exploring individual characteristics and job descriptions of Emergency Medicine Diversity, Equity, and Inclusion Leaders: Over the last few years, departments of EM have begun to approach DEI in a more systematic and holistic approach and have formed leaders dedicated to running DEI committees and, on occasion, appointing Vice-Chairs of DEI. Given the recent expansion in this structural approach, the specific roles and titles are not well described in the literature. This project is a self-reported electronically distributed survey designed to better understand the current landscape of DEI leaders in emergency medicine. We will reach out to academic institutions across the United States to identify who, if anyone, in the department is a DEI department lead and report details of their job description. ____________________________________________________________________________ Role - Data collection and analysis. Manuscript preparation (literature review, writing); IRB Status - Under departmental review (formal IRB to follow); Skills - None, there is some special software involved (Qualtrics) which is easy to learn and I can teach to any student. | Ryan Tsuchida, rtsuchida@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudmcjjXBDXS0Te1gk-4rxRkci1NRU2ibOTR2a3qVoGGYii5kjvun_hK01zQ3z5pH0Y | ||||||||||||
| 07/12/2021 | watson@ortho.wisc.edu | Drew | Watson | MD, MS | Assistant Professor | 6.082.636.647 | Orthopedics and Rehabilitation | Sports Medicine | Pediatrics | Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children | The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy 12-14 year old are currently being recruited for participation. Testing includes determination of height, weight, body composition by whole body MRI, maximal oxygen consumption by cycle ergometry, and cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates.We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the right ventricle and the ventricular response to exercise. Lab website: https://ortho.wisc.edu/research/labs/watson/ | 0 | Students will be actively involved in reviewing the current literature relevant to this project, as well as data collection, management, and analysis. This will include hands-on data collection from participants during maximal exercise testing and cardiac MRI. It is expected that this will culminate in the development of an abstract eligible for submission to a national scientific meeting and a possible peer-reviewed manuscript if interested. In the event that data collection is delayed or prevented by COVID-19 additional projects are available utilizing existing data previously collected from other projects including risk factors for injuries in athletes, the psychosocial impacts of injuries, COVID-19 risk in sports, and others. | Considerable independence is expected and much of the work not related to data collection will be conducted remotely. | Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. Data collection techniques will be taught through supervise dlearning during study data collections. | Approved | Yes | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | PhD students | Haraldsdottir H, Watson AM, Pegelow DF, Palta M, Tetri LH, Levin TS, Brix MD, Centanni RM, Goss KN, Eldridge MM. Blunted cardiac exercise response in preterm children. Eur J Appl Phys 2020, ePub ahead of print. Goss KN, Haraldsdottir K, Beshish AG, Barton GP, Macdonald JA, Levin TS, Watson AM, Palta M, Chesler NC, Francois CJ, Wieben O, Eldridge MW. Biventricular inefficiency in adults born preterm. JAMA Cardiology 2020 (ePub ahead of print). Haraldsdottir K, Watson AM, Beshish AG, Pegelow DF, Palta M, Tetri LH, Brix MD, Centanni, RM, Goss, KN, Eldridge MW. Heart Rate Recovery After Maximal Exercise Is Impaired in Healthy Young Adults Born Preterm. Eur J Appl Physiol 2019 (Epub Ahead of Print). Watson A, Coutinho C, Haraldsdottir K, Brickson S, Dunn W, Eldridge M. In-Season Changes in Ventricular Morphology and Systolic Function in Adolescent Female Athletes. Eur J Sports Sci 2018:534-540. Haraldsdottir K, Watson AM, Goss KN, Beshish AG, Pegelow DF, Palta M, Tetri LH, Barton GP, Brix MD, Centanni RM, Eldridge MW. Impaired Autonomic Function in Adolescents Born Preterm. Phys Rep:2018;6:e13620. Watson A, Eickhoff J, Nemeth B, Carell A. In Non-Obese Children, BMI and Fitness Are Independently Related to Insulin Sensitivity. Pediatr Exerc Sci Apr 2015;27:203-7. | No | Angela Riesing (riesing@ortho.wisc.edu | No | Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children: The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy 12-14 year old are currently being recruited for participation. Testing includes determination of height, weight, body composition by whole body MRI, maximal oxygen consumption by cycle ergometry, and cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates.We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the right ventricle and the ventricular response to exercise. Lab website: https://ortho.wisc.edu/research/labs/watson/ ____________________________________________________________________________ Role - Students will be actively involved in reviewing the current literature relevant to this project, as well as data collection, management, and analysis. This will include hands-on data collection from participants during maximal exercise testing and cardiac MRI. It is expected that this will culminate in the development of an abstract eligible for submission to a national scientific meeting and a possible peer-reviewed manuscript if interested. In the event that data collection is delayed or prevented by COVID-19 additional projects are available utilizing existing data previously collected from other projects including risk factors for injuries in athletes, the psychosocial impacts of injuries, COVID-19 risk in sports, and others.; IRB Status - Approved; Skills - Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. Data collection techniques will be taught through supervise dlearning during study data collections. | Drew Watson, watson@ortho.wisc.edu -- Co-Mentor: | ||||||||
| 09/12/2021 | baweaver@wisc.edu | Beth | Weaver | PhD | Associate Professor | 6.082.635.309 | Cell and Regenerative Biology | Oncology | Pippa Cosper, MD, PhD | cosper@wisc.edu | Human Oncology | CIN as a biomarker of radiation sensitivity | Our overall goal is to determine whether chromosomal instability (CIN) sensitizes cervical and head and neck cancers (HNC) to radiation therapy and can be used as a predictive biomarker of treatment response. Definitive (chemo)radiation is the standard of care for these patients, though individual patient responses vary widely. Despite improvements in technology, there has been little progress in predicting radiosensitivity of tumors and all patients continue to be treated similarly without consideration of individual tumor biology. This results in a substantial portion of tumors, ~40% of locally advanced HNC, that incompletely respond or recur (1). At the other end of the spectrum, patients whose tumors completely respond often suffer treatment related morbidity, which could be reduced by dose de-escalation if a validated method was available to identify these treatment-sensitive tumors. Here we will test the innovative hypothesis, which is based on extensive preclinical and translational evidence, that measurement of CIN using a 6-chromosome FISH assay we have developed can allow prediction of which patients will benefit from dose de-escalation and which patients will benefit from inclusion of additional therapy. CIN, the recurrent missegregation of one or more chromosomes during multiple cell divisions, results in aneuploidy, an abnormal chromosome content. Aneuploidy is common in cancer, which led to the hypothesis that aneuploidy promotes tumorigenesis (2-5). However, our laboratory and others have discovered that aneuploidy can promote tumors, suppress them, or do neither, depending on the degree of CIN: low rates of CIN weakly promote tumors, while high rates of CIN cause cell death and suppress tumors. Importantly, combining two insults that each cause low CIN results in high CIN, cell death, and tumor suppression. We recently discovered that the taxane paclitaxel induces CIN in primary breast cancers, supporting a model in which paclitaxel exerts its efficacy by increasing the rate of CIN over a maximally tolerated threshold. Radiation also increases CIN, suggesting that tumors that exhibit inherent low CIN prior to treatment are preferentially sensitive to the CIN induced by radiation. By contrast, tumors that initially lack CIN may be more resistant to radiation since it only raises CIN to a low, tolerable level. These cancers could benefit from additional treatments that independently increase CIN, such as paclitaxel or its analog docetaxel. Consistent with this hypothesis, our preliminary data in cervical and HNC cell lines and HNC patient derived xenograft (PDX) tumors reveal that pre-treatment CIN sensitizes cancers to radiation and could be used as a predictive marker for radiation response. Weaver lab website: https://weaver.crb.wisc.edu/ | 0 | chart review to identify patients treated with definitive chemoradiation; microscopic analysis of CIN | After training, the student is expected to work independently, in consultation with mentors | Training will be provided. | approved | Yes | No (plan to use Dean's Office Funds) | Yes | Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students | Zasadil, L.M., Andersen, K., Ryan, S.D., Yeum, D., Raines, R., Burkard, M.E., and Weaver, B.A. 2014. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Science Transl Med 6:229ra43. Zasadil L.M., Britigan E.M.C., Ryan S.D., Kaur C., Guckenberger D.J., Beebe, D.J., Moser A.R., Weaver B.A. 2016. High rates of chromosome missegregation suppress tumor progression, but do not inhibit tumor initiation. Mol Biol Cell 27: 1981-9. Burkard M.E. and Weaver B.A. 2017. Tuning chromosomal instability to optimize tumor fitness. Cancer Discov 7: 134-136. Funk, L.C., Wan, J., Ryan, S.D., Kaur, C., Sullivan, R., Roopra, A., and Weaver, B.A. 2020. p53 is not required for high CIN to induce tumor suppression. Molecular Cancer Research. doi: 10.1158/1541-7786.MCR-20-0488. Scribano et al, Chromosomal instability sensitizes tumors to multipolar divisions induced by paclitaxel, in revision. | Yes | N/A | Yes | CIN as a biomarker of radiation sensitivity: Our overall goal is to determine whether chromosomal instability (CIN) sensitizes cervical and head and neck cancers (HNC) to radiation therapy and can be used as a predictive biomarker of treatment response. Definitive (chemo)radiation is the standard of care for these patients, though individual patient responses vary widely. Despite improvements in technology, there has been little progress in predicting radiosensitivity of tumors and all patients continue to be treated similarly without consideration of individual tumor biology. This results in a substantial portion of tumors, ~40% of locally advanced HNC, that incompletely respond or recur (1). At the other end of the spectrum, patients whose tumors completely respond often suffer treatment related morbidity, which could be reduced by dose de-escalation if a validated method was available to identify these treatment-sensitive tumors. Here we will test the innovative hypothesis, which is based on extensive preclinical and translational evidence, that measurement of CIN using a 6-chromosome FISH assay we have developed can allow prediction of which patients will benefit from dose de-escalation and which patients will benefit from inclusion of additional therapy. CIN, the recurrent missegregation of one or more chromosomes during multiple cell divisions, results in aneuploidy, an abnormal chromosome content. Aneuploidy is common in cancer, which led to the hypothesis that aneuploidy promotes tumorigenesis (2-5). However, our laboratory and others have discovered that aneuploidy can promote tumors, suppress them, or do neither, depending on the degree of CIN: low rates of CIN weakly promote tumors, while high rates of CIN cause cell death and suppress tumors. Importantly, combining two insults that each cause low CIN results in high CIN, cell death, and tumor suppression. We recently discovered that the taxane paclitaxel induces CIN in primary breast cancers, supporting a model in which paclitaxel exerts its efficacy by increasing the rate of CIN over a maximally tolerated threshold. Radiation also increases CIN, suggesting that tumors that exhibit inherent low CIN prior to treatment are preferentially sensitive to the CIN induced by radiation. By contrast, tumors that initially lack CIN may be more resistant to radiation since it only raises CIN to a low, tolerable level. These cancers could benefit from additional treatments that independently increase CIN, such as paclitaxel or its analog docetaxel. Consistent with this hypothesis, our preliminary data in cervical and HNC cell lines and HNC patient derived xenograft (PDX) tumors reveal that pre-treatment CIN sensitizes cancers to radiation and could be used as a predictive marker for radiation response. Weaver lab website: https://weaver.crb.wisc.edu/ ____________________________________________________________________________ Role - chart review to identify patients treated with definitive chemoradiation; microscopic analysis of CIN; IRB Status - approved; Skills - Training will be provided. | Beth Weaver, baweaver@wisc.edu -- Co-Mentor: Pippa Cosper, MD, PhD cosper@wisc.edu | ||||||
| 07/01/2022 | alwentland@wisc.edu | Andrew | Wentland | MD, PhD | Assistant Professor | Radiology | Abdominal Imaging | Medical Physics | Identification of Complex Cystic Renal Lesions on Non-Contrast CT | The Bosniak classification system is used to evaluate cystic renal lesions and determine their risk of malignancy. Some of the features described in this classification system depend on the use of intravenous (IV) contrast on CT images. However, it is unknown how well the lesions can be categorized in the absence of contrast. The purpose of this study is to categorize cystic renal lesions on non-contrast CT images and compare the categorization to lesions identified on contrast-enhanced CT images. The results of this study have the potential to significantly improve the clinical management of patients with incidentally detected cystic renal lesions on CT. | 1 | The student will be the primary investigator on the project and will take the lead on curating, processing, and analyzing data. Abstract submission and associated conference presentation, along with first authorship on a paper, are possible for the motivated student. | The student’s advisor is readily available for help, and other students in the lab are available to assist if needed. Otherwise this project will require a moderate level of independence following the initial training period. | Required: Basic computer skills, including Excel. Otherwise, the successful student will exhibit adaptive thinking, strong critical thinking and communication skills, and motivation. | Approved | No | If Dean's office funds are unavailable, I have startup funds that can be used | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | PhD students, UW undergraduates interested in research | No | N/A | No | Identification of Complex Cystic Renal Lesions on Non-Contrast CT: The Bosniak classification system is used to evaluate cystic renal lesions and determine their risk of malignancy. Some of the features described in this classification system depend on the use of intravenous (IV) contrast on CT images. However, it is unknown how well the lesions can be categorized in the absence of contrast. The purpose of this study is to categorize cystic renal lesions on non-contrast CT images and compare the categorization to lesions identified on contrast-enhanced CT images. The results of this study have the potential to significantly improve the clinical management of patients with incidentally detected cystic renal lesions on CT. ____________________________________________________________________________ Role - The student will be the primary investigator on the project and will take the lead on curating, processing, and analyzing data. Abstract submission and associated conference presentation, along with first authorship on a paper, are possible for the motivated student.; IRB Status - Approved; Skills - Required: Basic computer skills, including Excel. Otherwise, the successful student will exhibit adaptive thinking, strong critical thinking and communication skills, and motivation. | Andrew Wentland, alwentland@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueTznRYpANdWub9Khz89woLLEdAfVFFWxg56ehVqpjpCczs2P-fgZsnExRHDexP7vQ | |||||||||
| 14/12/2021 | westmark@wisc.edu | Cara | Westmark | PhD | Assistant Professor | 6.082.629.730 | Neurology | SMPH | Testing Dietary Interventions in an Autism Mouse Model | We are testing the effects of modified ketogenic diets on neurological outcomes (hyperactivty, sleep, learning & memory, motor coordination) in a mouse model of fragile X syndrome, which is on the autism spectrum. The project involves designing test diets, dosing mice, performing mouse behavioral assays and euthanizing animals/collecting tissue samples as well as wet bench molecular biology work to genotype animals and screen biomarkers in tissue samples. We would love to have an enthusiastic, hardworking medical student test a new modified ketogenic diet to validate a possible mechanism underlying success of our prior work. Our lab webpage is at: https://www.facebook.com/profile.php?id=100057343603620 and a prior publication is at https://pubmed.ncbi.nlm.nih.gov/31958482/ | 1 | hands-on mouse husbandry, behavior testing and molecular biology research | a scientist will train/supervise until the student can work independently | willingness to work with mice; ability to follow directions and maintain a regular work schedule, i.e. 8am-4pm with some weekend work; attention to detail in record keeping | approved | Yes | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Unsure / Depends | N/A | Unsure / Depends | Testing Dietary Interventions in an Autism Mouse Model: We are testing the effects of modified ketogenic diets on neurological outcomes (hyperactivty, sleep, learning & memory, motor coordination) in a mouse model of fragile X syndrome, which is on the autism spectrum. The project involves designing test diets, dosing mice, performing mouse behavioral assays and euthanizing animals/collecting tissue samples as well as wet bench molecular biology work to genotype animals and screen biomarkers in tissue samples. We would love to have an enthusiastic, hardworking medical student test a new modified ketogenic diet to validate a possible mechanism underlying success of our prior work. Our lab webpage is at: https://www.facebook.com/profile.php?id=100057343603620 and a prior publication is at https://pubmed.ncbi.nlm.nih.gov/31958482/ ____________________________________________________________________________ Role - hands-on mouse husbandry, behavior testing and molecular biology research; IRB Status - approved; Skills - willingness to work with mice; ability to follow directions and maintain a regular work schedule, i.e. 8am-4pm with some weekend work; attention to detail in record keeping | Cara Westmark, westmark@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuebqKxHrdXbldKy8HHntHI7xaY-gnqVtJgG-3ijZw29C0X-E8eWvYVRnf5itW-R1hY | |||||||||
| 07/01/2022 | whiting@ortho.wisc.edu | Paul | Whiting | M.D. | Assistant Professor | 608 | Orthopedics and Rehabilitation | Trauma | Seth Williams, M.D. | swilliams@ortho.wisc.edu | Orthopedics and Rehabilitation | Spine | Multidisciplinary Opioid Reduction Program for Orthopaedic Trauma Patients | Data collection and analysis will be performed on orthopaedic trauma patients admitted and treated for isolated extremity fractures over a three-year period. The project will specifically investigate opioid medication usage before (calendar year 2018), during (calendar year 2019), and after (calendar year 2020) implementation of a multidisciplinary opioid reduction program. The primary outcomes of interest will be total inpatient opioid consumption and outpatient opioid medication prescription amounts provided upon discharge from the hospital. Students will work on separate projects for isolated extremity fractures; the isolated extremity fractures of focus are to be determined. The Shapiro student last summer completed a project on geriatric hip fractures. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the students will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor). | 0 | Students will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission | Students will be expected to accomplish all of the above tasks and work toward accomplishing these components of the project independently. However, appropriate guidance and direction will be provided (by the PI/co-investigators, research coordinator, and other research support staff) at the outset of the project and throughout the summer. We will schedule weekly meetings with the PI and/or other investigators/research staff. The purpose of these meetings will be to monitor project progress. Ongoing supervision/mentorship will be provided after the summer and throughout the process of abstract/manuscript submission, presentation, and publication. | The following skills are expected/required: - perform a literature search and compile a list of manuscript references - perform chart review in conjunction with mentors/co-investigators - maintain database (i.e. Excel, REDCap) - meet with the statistician to determine the statistical tools that will be used to analyze the data - participate in abstract/manuscript preparation and submission | IRB approved (Protocol #: 2021-0577). Students will be added to existing IRB. | No | Yes | Yes | Not currently interested or available for Non-Shapiro research mentoring of medical students | Not currently available to mentor other students | No | Heidi Ableidinger (Dept. of Orthopedics & Rehabilitation Student Services Coordinator) - ableidinger@ortho.wisc.edu; Gabrielle Kuhn (Orthopedic Trauma Research Coordinator) - otrc@ortho.wisc.edu | Yes | Multidisciplinary Opioid Reduction Program for Orthopaedic Trauma Patients: Data collection and analysis will be performed on orthopaedic trauma patients admitted and treated for isolated extremity fractures over a three-year period. The project will specifically investigate opioid medication usage before (calendar year 2018), during (calendar year 2019), and after (calendar year 2020) implementation of a multidisciplinary opioid reduction program. The primary outcomes of interest will be total inpatient opioid consumption and outpatient opioid medication prescription amounts provided upon discharge from the hospital. Students will work on separate projects for isolated extremity fractures; the isolated extremity fractures of focus are to be determined. The Shapiro student last summer completed a project on geriatric hip fractures. In addition, if the entire project is completed prior to the conclusion of the Shapiro Summer Research Program, the students will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor). ____________________________________________________________________________ Role - Students will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission; IRB Status - IRB approved (Protocol #: 2021-0577). Students will be added to existing IRB.; Skills - The following skills are expected/required: - perform a literature search and compile a list of manuscript references - perform chart review in conjunction with mentors/co-investigators - maintain database (i.e. Excel, REDCap) - meet with the statistician to determine the statistical tools that will be used to analyze the data - participate in abstract/manuscript preparation and submission | Paul Whiting, whiting@ortho.wisc.edu -- Co-Mentor: Seth Williams, M.D. swilliams@ortho.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufC47x3Eia-rHcwRXS0ynvWlMXoZELeJzqlQ-rvN7UPJOFej38GbTacjSh3f3EbsFc | |||||
| 09/12/2021 | mrwolff@medicine.wisc.edu | Matthew | Wolff | MD | Professor of Medicine (CHS) | 608 | Medicine | Cardiovascular Medicine | Timothy Hacker, Ph.D, Senior Scientist and Director, Animal Model Core Lab, SMPH | Th2@medicine.wisc.edu | Other | Core lab in SMPH | Cardiac function and imaging | The combined laboratories of Matthew Wolff, MD, Professor (CHS), Cardiovascular Medicine and Timothy Hacker, PhD, Senior Scientist and Director, Animal Model Core Lab, School of Medicine and Public Health, have several exciting research options for Shapiro Summer Research Program Awardees: 1. Small Animal Cardiac Ultrasound Imaging Our lab recently obtained a new small animal ultrasound machine (FujiFilm Visual Sonics, Vevo 3100). This machine is a significant upgrade from our old machine, with several new features which need to be validated. We are particularly excited about two new features: 1) four-dimensional cardiac ultrasound, which captures the typical three spatial dimensions over one complete cardiac cycle at 100-300 frames per second and 2) strain, or the measure of tissue deformation over time, which is a clinically important measure of cardiac function, particularily early in cardiac disease. For this project the student’s role would be to help design and implement experiments to validate these new features in various mouse models of cardiovascular disease. In addition, the student would help prepare for and assist with mouse surgeries to create animal models of disease, ultrasound imaging and assist with data collection and analysis. This work is highly likely to result in a student project suitable for presentation at a national meeting and publication. 2. Novel nanogenerator cardiac pacemaker development in anesthetized swine Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. We plan to test the optimal location on the heart for maximal power output. For your project we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The student’s role would be to help with data collection and analysis, prepare for and assist with animal surgeries to place the device, blood collections, ultrasound imaging, ECG, and invasive physiological data collection. This work is less likely to generate a publication for the student. 3. Mechanisms of cardiac dysfunction and therapeutic recovery in an animal model of a familial dilated cardiomyopathy. We have maintained a colony of lmnaN195K/N175K mice, a murine model of a familial (genetic) dilated cardiomyopathy (FDC or genetic DCM) related to a lamin mutation (specifically lmnaN195K/WT). This model recapitulates the disease phenotype seen in the human familial DCM, including cardiac dilation, reduced cardiac output and ventricular ejection fraction, premature death, etc… We have also shown that 2 drugs prolong survival in this murine model: the p38 MAPK inhibitor A371797 and the mTORC1 inhibitor sirolimus (rapamycin). Based in large part on pre-clinical work from our laboratory, A371797 is now in a phase III multinational trial for lamin-associated FDC. However, the subcellular mechanism of action of A371797 remains unclear. We plan on looking at gene expression and phosphorylation of key proteins in the MAPK pathways as well as markers of autophagy and apoptosis in this model, with or without treatment, by Western blotting and other techniques. We will also construct a pressure overload model of heart failure in minimally affected heterozygotic mice (lmnaN195K/WT) created by surgical constriction of the thoracic aorta (TAC procedure). These mice, and controls will be examined by cardiac ultrasonography as described in project 2, and subcellar mechanisms will be examined by Western blotting. | 2 | major role in proposed research, with expected presentation/publication for all projects except the swine pacemaker study | Moderate, although we will train | spreadsheet skills necessary, Western blotting skills desirable for 3rd project | approved | Yes | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Fatkin et al, Missense mutations in the rod domain of the lamination's A/C gene as causes of dilated cardiomyopathy and conduction system disease. NEJM 1999; 341:1715-24. Markandeya et al, Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation. Heart Rhythm 2016; 11:2228-36 Hacker TA, Animal Models and Cardiac Extracellular Matrix Research, Adv Exp Med Biol., 2018; 1098: 45-48 Kumari et al, Biomodal right ventricular dysfunction after postnatal hyperopia exposure: implications for the preterm heart. Am J Physiology Circ Physiol. 2019; 317; H1272-H1281 | Yes | N?A | Yes | Cardiac function and imaging: The combined laboratories of Matthew Wolff, MD, Professor (CHS), Cardiovascular Medicine and Timothy Hacker, PhD, Senior Scientist and Director, Animal Model Core Lab, School of Medicine and Public Health, have several exciting research options for Shapiro Summer Research Program Awardees: 1. Small Animal Cardiac Ultrasound Imaging Our lab recently obtained a new small animal ultrasound machine (FujiFilm Visual Sonics, Vevo 3100). This machine is a significant upgrade from our old machine, with several new features which need to be validated. We are particularly excited about two new features: 1) four-dimensional cardiac ultrasound, which captures the typical three spatial dimensions over one complete cardiac cycle at 100-300 frames per second and 2) strain, or the measure of tissue deformation over time, which is a clinically important measure of cardiac function, particularily early in cardiac disease. For this project the student’s role would be to help design and implement experiments to validate these new features in various mouse models of cardiovascular disease. In addition, the student would help prepare for and assist with mouse surgeries to create animal models of disease, ultrasound imaging and assist with data collection and analysis. This work is highly likely to result in a student project suitable for presentation at a national meeting and publication. 2. Novel nanogenerator cardiac pacemaker development in anesthetized swine Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. We plan to test the optimal location on the heart for maximal power output. For your project we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The student’s role would be to help with data collection and analysis, prepare for and assist with animal surgeries to place the device, blood collections, ultrasound imaging, ECG, and invasive physiological data collection. This work is less likely to generate a publication for the student. 3. Mechanisms of cardiac dysfunction and therapeutic recovery in an animal model of a familial dilated cardiomyopathy. We have maintained a colony of lmnaN195K/N175K mice, a murine model of a familial (genetic) dilated cardiomyopathy (FDC or genetic DCM) related to a lamin mutation (specifically lmnaN195K/WT). This model recapitulates the disease phenotype seen in the human familial DCM, including cardiac dilation, reduced cardiac output and ventricular ejection fraction, premature death, etc… We have also shown that 2 drugs prolong survival in this murine model: the p38 MAPK inhibitor A371797 and the mTORC1 inhibitor sirolimus (rapamycin). Based in large part on pre-clinical work from our laboratory, A371797 is now in a phase III multinational trial for lamin-associated FDC. However, the subcellular mechanism of action of A371797 remains unclear. We plan on looking at gene expression and phosphorylation of key proteins in the MAPK pathways as well as markers of autophagy and apoptosis in this model, with or without treatment, by Western blotting and other techniques. We will also construct a pressure overload model of heart failure in minimally affected heterozygotic mice (lmnaN195K/WT) created by surgical constriction of the thoracic aorta (TAC procedure). These mice, and controls will be examined by cardiac ultrasonography as described in project 2, and subcellar mechanisms will be examined by Western blotting. ____________________________________________________________________________ Role - major role in proposed research, with expected presentation/publication for all projects except the swine pacemaker study; IRB Status - approved; Skills - spreadsheet skills necessary, Western blotting skills desirable for 3rd project | Matthew Wolff, mrwolff@medicine.wisc.edu -- Co-Mentor: Timothy Hacker, Ph.D, Senior Scientist and Director, Animal Model Core Lab, SMPH Th2@medicine.wisc.edu | |||||
| 13/01/2022 | rwoods@uwhealth.org | Ryan | Woods | MD, MPH | Assistant Professor of Radiology | Radiology | Radiology | Assessment of Radiologists Experience with EMR Onboarding | The purpose of this project is to analyze data from a survey to academic radiologists which addresses their experience with electronic medical record onboarding after hiring. The student involved in this project would help with data collection and analysis, as well as abstract and manuscript preparation. | 0 | The student involved in this project would help with data collection and analysis, as well as abstract and manuscript preparation. | None required | To be submitted to IRB once student is identified | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | No | Lorene Seman (lseman@uwhealth.org) | No | Assessment of Radiologists Experience with EMR Onboarding: The purpose of this project is to analyze data from a survey to academic radiologists which addresses their experience with electronic medical record onboarding after hiring. The student involved in this project would help with data collection and analysis, as well as abstract and manuscript preparation. ____________________________________________________________________________ Role - The student involved in this project would help with data collection and analysis, as well as abstract and manuscript preparation. ; IRB Status - To be submitted to IRB once student is identified; Skills - None required | Ryan Woods, rwoods@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufXDrfdJTcQ4Hb3Oh90cD6o33zXrABRBOYFB2wSJviVq5PLfXso8a1lRvcH8LwHCak | |||||||||||
| 13/01/2022 | rwoods@uwhealth.org | Ryan | Woods | MD, MPH | Breast Imaging Informatics Projects | Radiology | Various Projects in Breast Imaging Informatics | Several projects are available within Breast Imaging Informatics: Assessment of updated electronic radiology pathology concordance workflow, assessment of using MyChart screening mammography exam questions, review paper of breast imaging informatics | 1 | Depending on the project, the student role could involve data collection and analysis, and will most certainly involve abstract and manuscript preparation. | Moderate | None in particular | To be submitted if a student is identified | No | No (plan to use Dean's Office Funds) | Yes | Research Electives for credit | Not currently available to mentor other students | No | Lorene Seman (lseman@uwhealth.org) | Yes | Various Projects in Breast Imaging Informatics: Several projects are available within Breast Imaging Informatics: Assessment of updated electronic radiology pathology concordance workflow, assessment of using MyChart screening mammography exam questions, review paper of breast imaging informatics ____________________________________________________________________________ Role - Depending on the project, the student role could involve data collection and analysis, and will most certainly involve abstract and manuscript preparation. ; IRB Status - To be submitted if a student is identified; Skills - None in particular | Ryan Woods, rwoods@uwhealth.org -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucR8YittqO60ySFaw0KTrxqBiO2WuIWYF4Gr7fm2nS9K-aujw1qdrUfDddNfdhlOFw | |||||||||||
| 03/01/2022 | mfwyman@wisc.edu | Mary | Wyman | PhD | Assoc Prof, Clin Adj / Scientist | 608 | Medicine | Geriatrics/Gerontology | Psychiatry | Carey Gleason, PhD | ceg@medicine.wisc.edu | Medicine | Geriatrics/Gerontology | Service Utilization by older adults/elderly and family caregivers | Dr Wyman is a clinical psychologist with a research program focused on aging and health services. She is funded by a career development award to examine utilization of mental health services by older adults with cognitive loss in the Veterans Affairs healthcare system. A additional, linked topic of research is on factors associated with service utilization by family caregivers in the Oneida Nation of Wisconsin (the state's most populous tribe) using qualitative and quantitative methods. The Shapiro scholar will focus on one of these areas, with the opportunity for shadowing and exposure to both settings. | 0 | primary data collection in a mental health care setting; data analysis (qualitative) | moderate to large | good communication skills. Interest in learning qualitative data analysis | approved | Yes | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | Yes | N/A | Yes | Service Utilization by older adults/elderly and family caregivers: Dr Wyman is a clinical psychologist with a research program focused on aging and health services. She is funded by a career development award to examine utilization of mental health services by older adults with cognitive loss in the Veterans Affairs healthcare system. A additional, linked topic of research is on factors associated with service utilization by family caregivers in the Oneida Nation of Wisconsin (the state's most populous tribe) using qualitative and quantitative methods. The Shapiro scholar will focus on one of these areas, with the opportunity for shadowing and exposure to both settings. ____________________________________________________________________________ Role - primary data collection in a mental health care setting; data analysis (qualitative); IRB Status - approved; Skills - good communication skills. Interest in learning qualitative data analysis | Mary Wyman, mfwyman@wisc.edu -- Co-Mentor: Carey Gleason, PhD ceg@medicine.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc8MpM64T0xtz2UUjm8I9paOyGFYB1dEptgZbz_th1PK26wURdtuSVrS94jo4qXoIk | ||||
| 21/01/2022 | szafar2@wisc.edu | S. Nabeel | Zafar | MD MPH | Assistant Professor of Surgery | 4.104.467.225 | Surgery | Surgical Oncology | Girma Tefera | tefera@surgery.wisc.edu | Surgery | Vascular Surgery | Improving Surgical Care by Developing a Perioperative Registry in Hawassa, Ethiopia | To improve the surgical care in low-and-middle income countries we need systems in place to measure surgical outcomes and identify areas of improvement. In this project we are developing and piloting a web-based perioperative registry intended to be used in LMICs to enhance surgical outcomes research and for qualitive improvement initiatives. The student will be expected to partake in data collection efforts on the ground at University of Hawassa in Awasa, Ethiopia. The department of surgery at UW has a strong relationship with the University of Hawassa and this project will enhance ongoing efforts to improve surgical care, surgical capacity, and surgical research capacity in LMICs. | 1 | Data collection, implementation of registry, data analysis, and reporting | Will be supervised. | A curious intelligent mind. Some grit | Submitted | No | Yes | Yes | Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | pavao@surgery.wisc.edu | Yes | Improving Surgical Care by Developing a Perioperative Registry in Hawassa, Ethiopia: To improve the surgical care in low-and-middle income countries we need systems in place to measure surgical outcomes and identify areas of improvement. In this project we are developing and piloting a web-based perioperative registry intended to be used in LMICs to enhance surgical outcomes research and for qualitive improvement initiatives. The student will be expected to partake in data collection efforts on the ground at University of Hawassa in Awasa, Ethiopia. The department of surgery at UW has a strong relationship with the University of Hawassa and this project will enhance ongoing efforts to improve surgical care, surgical capacity, and surgical research capacity in LMICs. ____________________________________________________________________________ Role - Data collection, implementation of registry, data analysis, and reporting; IRB Status - Submitted; Skills - A curious intelligent mind. Some grit | S. Nabeel Zafar, szafar2@wisc.edu -- Co-Mentor: Girma Tefera tefera@surgery.wisc.edu | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufEXWMIgdrQ3U33VBdNyLVTyINetd3cjhF8z_bdZe-oLT8slF5MNNKa4y_HsJWGMvo | |||||
| 21/01/2022 | szafar2@wisc.edu | S. Nabeel | Zafar | MD MPH | Assistant Professor in Surgery | 4.104.467.225 | Surgery | Surgical Oncology | A Novel Registry for Pancreas Cancer | This project will use cutting advanced informatics to leverage several data sources to create a novel digital registry for patients with Pancreas Cancer in Wisconsin. This will lead to the development of artificial intelligence methods to extract and analyze data and use machine learning methods to predict outcomes. The student will learn more about pancreas cancer and its management, factors related to outcomes, and get familiar with informatics and big data in health care as well as modern data science methods in surgical research. | 1 | Participating in registry building, data collection through chart reviews, managing and analyzing data. Publish and present work | Will be partially supervised | An intelligent mind. Some data management background is good but not necessary | IRB approved | Pancreas TaskForce Grant | Yes | Yes | Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship) | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | No | pavao@surgery.wisc.edu | Yes | A Novel Registry for Pancreas Cancer : This project will use cutting advanced informatics to leverage several data sources to create a novel digital registry for patients with Pancreas Cancer in Wisconsin. This will lead to the development of artificial intelligence methods to extract and analyze data and use machine learning methods to predict outcomes. The student will learn more about pancreas cancer and its management, factors related to outcomes, and get familiar with informatics and big data in health care as well as modern data science methods in surgical research. ____________________________________________________________________________ Role - Participating in registry building, data collection through chart reviews, managing and analyzing data. Publish and present work; IRB Status - IRB approved; Skills - An intelligent mind. Some data management background is good but not necessary | S. Nabeel Zafar, szafar2@wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudsrDCUQqaOKcZdcyx1JwO8oTSUhac8ZVK7qtJGESEIbF6lTKNxtw-YJjzuZyrmgRQ | |||||||||
| 04/03/2022 | dshirley@medicine.wisc.edu | Daniel | Shirley | MD | Assistant Professor (CHS) | 6.082.652.676 | Medicine | Infectious Disease | Using lessons learned in COVID-19 care to plan for future pandemics | The student will help develop and deploy a survey and/or interview for healthcare providers and ancillary staff who cared for patients with COVID-19 to gain an understanding of lessons learned to prepare for the next pandemic. | 1 | help design survey and/or interview questions, deploy survey and/or interview healthcare providers/ancillary staff, compile and analyze results. | moderate | nothing specific | to be determined | No | No (plan to use Dean's Office Funds) | Yes | Shorter term projects, Research Electives for credit | MPH students | No | N/A | Yes | Using lessons learned in COVID-19 care to plan for future pandemics: The student will help develop and deploy a survey and/or interview for healthcare providers and ancillary staff who cared for patients with COVID-19 to gain an understanding of lessons learned to prepare for the next pandemic. ____________________________________________________________________________ Role - help design survey and/or interview questions, deploy survey and/or interview healthcare providers/ancillary staff, compile and analyze results.; IRB Status - to be determined; Skills - nothing specific | Daniel Shirley, dshirley@medicine.wisc.edu -- Co-Mentor: | https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudqlFqUKw9enchGf65EdHwLkLfzoHzGrI-zChi1t3xq_65ruLHklZPsayKFRiQnRD0 | |||||||||
| 07/12/2021 | zuegge@wisc.edu | Karin | Zuegge | MD | Associate Professor | 6.082.638.100 | Anesthesiology | Carbon Footprint of Healthcare | Background Pollution prevention is the new patient safety movement. Climate change is going to be one of the biggest concerns for public health in the 21st century. (UW population health institute: https://www.countyhealthrankings.org/explore-health-rankings/measures-data-sources/2019-measures) How does health care contribute to climate change? The health care sector is the largest contributor to carbon emissions in the United States after the food service industry. Having a more accurate picture of the carbon footprint of an organization and where the emissions stem from can help identify areas of improvement and potentially drive policy for change. (https://jamanetwork.com/journals/jama/fullarticle/184856) Data gathering The sustainability program has data on waste and energy usage across the organization. Compiling this data into a comprehensive report describing the emissions profile of UW Health as a whole would be the main goal of this project. Another aspect of this project could be to seek data where it does not exist in the form of, e.g. waste audits. Sustainability program website: https://www.uwhealth.org/sustainable-conservation-healthy-environment/green-steps/40629 Literature collection: https://anesthesia.wisc.edu/sustainable-anesthesiology/ | 1 | Scope emissions determination, data gathering and reporting | Variable, can be done remotely with frequent check-in | Enthusiasm for sustainability and basic spreadsheet knowledge | N/A | No | Yes | Yes | Shorter term projects, Research Electives for credit | MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research | https://pubmed.ncbi.nlm.nih.gov/31094796/ and https://pubs.asahq.org/monitor/issue/84/4 | Yes | Mary Roth: maroth4@wisc.edu Mary Evers Statz: mary.statz@uwmf.wisc.edu | Yes | Carbon Footprint of Healthcare: Background Pollution prevention is the new patient safety movement. Climate change is going to be one of the biggest concerns for public health in the 21st century. (UW population health institute: https://www.countyhealthrankings.org/explore-health-rankings/measures-data-sources/2019-measures) How does health care contribute to climate change? The health care sector is the largest contributor to carbon emissions in the United States after the food service industry. Having a more accurate picture of the carbon footprint of an organization and where the emissions stem from can help identify areas of improvement and potentially drive policy for change. (https://jamanetwork.com/journals/jama/fullarticle/184856) Data gathering The sustainability program has data on waste and energy usage across the organization. Compiling this data into a comprehensive report describing the emissions profile of UW Health as a whole would be the main goal of this project. Another aspect of this project could be to seek data where it does not exist in the form of, e.g. waste audits. Sustainability program website: https://www.uwhealth.org/sustainable-conservation-healthy-environment/green-steps/40629 Literature collection: https://anesthesia.wisc.edu/sustainable-anesthesiology/ ____________________________________________________________________________ Role - Scope emissions determination, data gathering and reporting; IRB Status - N/A; Skills - Enthusiasm for sustainability and basic spreadsheet knowledge | Karin Zuegge, zuegge@wisc.edu -- Co-Mentor: | ||||||||||
| Timestamp | Email Address | Mentor First Name | Mentor Last Name | Degree | Title | Phone Number | Dept. | Primary Department Division | Secondary Department | Secondary Department Division | Co-Mentor Name | Co-Mentor Email | Co-Mentor's Primary Department | Co-Mentor's Primary Department's Division | Project Title | Project Description | Open Slots | Student's Role | Degree of Independence Required | Skills Required | IRB Status of Project | Do you have current NIH or other external funding? | Do you have funding to cover 50% of the Shapiro summer student's stipend? | Do you have resources to provide all needed supplies to support the student research experience? | Non-Shapiro Opportunities | Are you interested in mentoring non-medical students? | Does your project focus, in part or fully, on medical education? | Have you completed any mentoring training? | Please include names and emails of key staff in your department or lab who will need to be informed of your incoming Shapiro students. | Option | Is your project related (in part or completely) to public health (e.g., clinical QI, community health, program planning/evaluation, epidemiologic studies)? | Project Information | Mentor Information | Response URL | Test Email Address |