Shapiro Projects

Please note that ALL projects with open slots are available to Shapiro applicants. “Non-Shapiro Opportunities” refer to opportunities available for medical students interested in a shorter term (non-summer) projects and yearlong projects.

Summer Research 2021

Timestamp	Email Address	Mentor First Name	Mentor Last Name	Degree	Title	Phone Number	Dept.	Primary Department Division	Secondary Department	Secondary Department Division	Co-Mentor Name	Co-Mentor Email	Co-Mentor's Primary Department	Co-Mentor's Primary Department's Division	Project Title	Project Description	Open Slots	Student's Role	Degree of Independence Required	Skills Required	IRB Status of Project	Do you have current NIH or other external funding?	Do you have funding to cover 50% of the Shapiro summer student's stipend?	Do you have resources to provide all needed supplies to support the student research experience?	Non-Shapiro Opportunities	Are you interested in mentoring non-medical students?	Please list all relevant manuscripts (published or in preparation) in the last 5 years that are directly relevant to the project you proposed.	Have you completed any mentoring training?	Please include names and contact information of key staff in your department or lab who will need to be informed of your incoming Shapiro students	Project Information	Mentor Information	Response URL	Test Email Address
21/11/2019	epetty@wisc.edu	Elizabeth	Petty	MD	Professor, Senior Associate Dean	608	Pediatrics	Pediatrics - Genetics and Metabolism	Other	Academic Affairs - Dean's Office Administration	Sherryl Pertzborn, MBA; Kendra Hogan, MS, MPH, JD		Other	Academic Affairs - Dean's Office Administration	Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning	The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education.	2	Depends on student’s interests	Students will meet with mentors formally on a weekly basis and will be expected to make progress on goals independently. Oversight and consultataion with involved faculty and staff will be readily avaiable.	Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus.	N/A	Yes	Yes	Yes	Shorter term projects	Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/)	N/A	Yes	N/A	Applications of LEAN Quality Improvement to Enhance Outcomes and Optimize Learning: The goal of this project is to use formal evaluation and assessment practices to analyze the implementation and outcomes of innovative programs that are designed to enhance faculty, staff, and/or student education programs. Depending on student interests, existing data sets can be mined or new data can be gathered in areas that are high priority for ongoing quality improvement. Students will work closely with faculty and staff in academic affairs administration and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Depending on interests of students, students may be able to participate in administrative leadership meetings, shadow in genetics clinic, engage in curriculum development, etc. The research opportunity will be tailored to meet the interests of students who are interested in exploring potential future careers as leaders in academic medicine or medical education. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - N/A; Skills - Must have strong computer based skills, communication, and collaboration skills. Expereince with surveys, focus groups, data analysis is a plus.	Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: Sherryl Pertzborn, MBA; Kendra Hogan, MS, MPH, JD	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuehiOW9caGSV6b8O97Sph0Z4VNJVCtn7sBgOM0HzdIddzg3RIp1elELKhzESSc-TxY	jczachman@gmail.com
21/11/2019	epetty@wisc.edu	Elizabeth	Petty	MD	Professor, Pediatrics	608	Pediatrics	Genetics and Metabolism	Other	Academic Affairs - Deans Office Administration	Casey Reiser, MS		Pediatrics	Genetics and Metabolism	Applications and Implications of Genetics and Genomics - An Understanding of Professional and Public Perspectives	Medical and/or Genetic Counselor students will have an opportunity to work with existing data sets or create new ones that explore the clinical, economic, ethical, legal, and/or sociopolictical impacts of advances of applications in genetic/genomic knowledge on individuals and populations depending on which project in this area they chose. The student(s) have an opportunity to chose from different projects and develop their focus of interest. Students will be also encouraged to attend genetics clinic conferences and shadow in genetics clinics. This research will be geared toward students who have interests in a career that includes serving individuals, families, or populations with, or at risk for, genetic conditions.	2	Depends on student’s interests	Students will meet formally with mentors once each week and have informal interactions as needed to ensure sucess of the project. The student will be expected to follow a timeline and make progress on all agreed upon goals in an independent manner.	Outstanding computer, communication, and collaboration skills are essential. Past expereince with hypothesis driven research, surveys, and data analysis a plus.	Depends on specific project, for projects where IRB is needed, IRB already exisits or will be in place.	No	Yes	Yes	Shorter term projects	Genetic Counseling students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/)	N/A	Yes	N/A	Applications and Implications of Genetics and Genomics - An Understanding of Professional and Public Perspectives: Medical and/or Genetic Counselor students will have an opportunity to work with existing data sets or create new ones that explore the clinical, economic, ethical, legal, and/or sociopolictical impacts of advances of applications in genetic/genomic knowledge on individuals and populations depending on which project in this area they chose. The student(s) have an opportunity to chose from different projects and develop their focus of interest. Students will be also encouraged to attend genetics clinic conferences and shadow in genetics clinics. This research will be geared toward students who have interests in a career that includes serving individuals, families, or populations with, or at risk for, genetic conditions. ____________________________________________________________________________ Role - Depends on student’s interests; IRB Status - Depends on specific project, for projects where IRB is needed, IRB already exisits or will be in place.; Skills - Outstanding computer, communication, and collaboration skills are essential. Past expereince with hypothesis driven research, surveys, and data analysis a plus.	Elizabeth Petty, epetty@wisc.edu -- Co-Mentor: Casey Reiser, MS	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudhFrIrxHX5knB13yVLoAEAQcg1KYnmyZbYzBNemuEUfsCFe0PZoBlCndQb-vu_vg0	jim.helwig@wisc.edu
01/12/2020	emohr2@wisc.edu	Emma	Mohr	MD, PhD	Assistant Professor		Pediatrics	Infectious Diseases							Neurodevelopmental outcomes of children potentially exposed to Zika virus in utero	Neurodevelopmental outcomes of infants with potential Zika virus exposure: We are studying the neurodevelopmental outcomes of children who were born to Wisconsin women who traveled to Zika endemic regions during pregnancy. About 30% of children with known Zika virus infection during pregnancy have developmental deficits. The number of children with developmental deficits in our cohort of Wisconsin women with potential Zika virus exposure is not known yet. Our goal is to determine whether children with potential Zika-exposure are at higher risk for having developmental deficits compared with age-matched children with no prenatal travel to a Zika-endemic region. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ ____________________________________________________________________________ Role - Retrospective chart reviewer and data analyst; IRB Status - Will be submitted in January 2020; Skills - Proficient in Epic, Microsoft Excel and Word	0	Chart review, analysis	independent chart review, will need to be on site	Epic chart review skills	approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	PhD students, UW undergraduates interested in research	none	Yes	N/A	Neurodevelopmental outcomes of children potentially exposed to Zika virus in utero: Neurodevelopmental outcomes of infants with potential Zika virus exposure: We are studying the neurodevelopmental outcomes of children who were born to Wisconsin women who traveled to Zika endemic regions during pregnancy. About 30% of children with known Zika virus infection during pregnancy have developmental deficits. The number of children with developmental deficits in our cohort of Wisconsin women with potential Zika virus exposure is not known yet. Our goal is to determine whether children with potential Zika-exposure are at higher risk for having developmental deficits compared with age-matched children with no prenatal travel to a Zika-endemic region. Lab website: https://www.pediatrics.wisc.edu/research/research-groups/mohr/ ____________________________________________________________________________ Role - Retrospective chart reviewer and data analyst; IRB Status - Will be submitted in January 2020; Skills - Proficient in Epic, Microsoft Excel and Word ____________________________________________________________________________ Role - Chart review, analysis; IRB Status - approved; Skills - Epic chart review skills	Emma Mohr, emohr2@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudO4Sk_zgwOHl8mEWx610CI9U1zfKqHpwgBrnFHYpe_IIFlDxb0Bv_Ba9aLpcXlNR0
03/01/2021	mmathur@wisc.edu	Mala	Mathur	MD, MPH	Pediatrician	0	Pediatrics	General Pediatrics and Adolescent Medicine			Brad Kerr	bkerr@wisc.edu	Pediatrics		Qualitative Analysis of Parents’ Perspectives of Mindfulness	Emerging research suggests that mindfulness techniques can benefit parents and children resulting in decreased stress and improved health outcomes. In this project, we will be conducting semi-structured interviews with parents of children with and without asthma. We will be asking about their current mindfulness practices and their perceived barriers and benefits to engaging in mindfulness practices for themselves and with their children. We will then code the data, identify themes and analyze the data to understand how mindfulness can be introduced to parents for the health benefits of themselves and their children.	0	Assist with data coding and analysis, help write up the project for submission to the Academic Pediatric Association conference.	Moderate amount of independence is required	No specific skills will be required except a willingness to leanr about qualitative research and data analysis	In progress	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	MPH students	1)Mathur, et al. Parents' Acceptance of Learning about Mindfulness to Manage Pediatric Asthma, Children 2020, 7, 262. 2)Mathur, et. al. U.S. Parents' Acceptance of Learning about Mindfulness Practices	No	Christine Richards (crichards9@wisc.edu); Kathi Zich (kzich@wisc.edu)	Qualitative Analysis of Parents’ Perspectives of Mindfulness: Emerging research suggests that mindfulness techniques can benefit parents and children resulting in decreased stress and improved health outcomes. In this project, we will be conducting semi-structured interviews with parents of children with and without asthma. We will be asking about their current mindfulness practices and their perceived barriers and benefits to engaging in mindfulness practices for themselves and with their children. We will then code the data, identify themes and analyze the data to understand how mindfulness can be introduced to parents for the health benefits of themselves and their children. ____________________________________________________________________________ Role - Assist with data coding and analysis, help write up the project for submission to the Academic Pediatric Association conference. ; IRB Status - In progress; Skills - No specific skills will be required except a willingness to leanr about qualitative research and data analysis	Mala Mathur, mmathur@wisc.edu -- Co-Mentor: Brad Kerr bkerr@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf_N6jhibrI822rpPBSzbAD_8lw_B5-cAGeCOXoGxtbGxKU3sjqMGw-_puZ34mIkOk
02/12/2020	apeterson@pediatrics.wisc.edu	Mala	Peterson	MD	Associate Professor of Pediatrics, Division of Pediatric Cardiology	608	Pediatrics	Pediatric Cardiology			Kristen Marten DO, Assistant Professor of Pediatrics	kmarten2@wisc.edu	Pediatrics	General Pediatrics and Adolescent Medicine	Impact of COVID-19 on Cardiometabolic Health Parameters in Children	The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. We have noted that since the onset of COVID-19, many of our patients have struggled to maintain healthy lifestyle choices and consequently have had worsening of their laboratory markers of cardiovascular health, including cholesterol and insulin resistance. We would like to systematically investigate this through a database analysis and chart review. Additionally, any student involved in this project would have the opportunity to attend PPCC at AFCH and take advantage of other clinical opportunities within the division of pediatric cardiology.	0	Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired.	This project requires a self-motivated learner and strong work ethic, but the research team will provide support for this project.	None	Student will be involved in IRB submission which will take place Jan-April 2021	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	Not currently available to mentor other students	1. Stempel H, Dodge A, Marriott E, and Peterson AL. Referral patterns and cascade screening for familial hypercholesterolemia in a pediatric lipid clinic. J Pediatr 2016;178:285-287. PubMed PMID: 27529098. 2. DeSantes K, Dodge A, Eickhoff J, and Peterson AL. Improving universal pediatric lipid screening. J Pediatr 2017;188:87-90. PubMed PMID: 28595766. 3. Zawacki A, Dodge A, Woo K, Ralphe JC, and Peterson AL. In pediatric familial hypercholesterolemia, lipoprotein (a) is more predictive than LDL-C for early onset of cardiovascular disease in family members. J Clin Lipidol 2018;12(6):1445-1451. PubMed PMID: 30150142. 4. Zawacki A, Dodge A, Eickhoff J, Sun W, Marriott E, Ralphe JC, and Peterson AL. Novel lipid thresholds better predict need for pharmacotherapy. J Pediatr 2018;202:220-5. PubMed PMID: 30172432. 5. De Ferranti SD, Steinberger J, Ameduri R, Baker A, Gooding H, Kelly AS, Mietus-Snyder M, Mitsnefes MM, Peterson AL, St-Pierre J, Urbina EM, Zachariah JP, Zaldi AN. Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association. Circulation 2019;139:e603-e634. PubMed PMID: 30798614. 6. Wilemon KA, Patel J, Aguilar-Salinas C, Ahmed CD, Alkhnifsawi M, Almahmeed W, Alonso R, Al-Rasadi K, Badimon L, Bernal LM, Bogsrud MP, Braun LT, Brunham L, Catapano, AL, Cillikova K, Corral P, Cuevas R, Defesche JC, Descamps OS, de Ferranti S, Eisele JL, Elikir G, Folco E, Freiberger T, Fuggetta F, Gaspar IM, Gesztes AG, Groselj U, Hamilton-Craig I, Hanauer-Mader G, Harada-Shiba M, Hastings G, Hovingh GK, Izar MC, Jamison A, Karlsson GN, Kayikcioglu M, Khoury MJ, Koob S, Koseki M, Lane S, Lima-Martinez MM, Lopez G, Martinez TL, Marais D, Marion L, Mata P, Maurina I, Maxwell D, Mehta R, Mensah GA, Miserez AR, Neely D, Nicholls SJ, Nohara A, Nordestgaard B, Ose L, Pallidis A, Pang J, Payne J, Peterson AL, Popescu MP, Puri R, Ray KK, Reda A, Sampietro T, Santos RD, Schalkers I, Schreier L, Shapiro M, Sijbrands E, Soffer D, Stefanutti C, Stoll M, Sy RG, Tamayo ML, Tilney MK, Tokgozoglu L, Tomlinson B, Vallejo-Vaz AJ, Vazquez-Cardenas A, de Luca PV, Wald DS, Watts GF, Wenger NK, Wolf M, Wood D, Zegerius A, Gaziano TA, and Gidding SS. Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action. JAMA Cardiol 2020;5(2)217-229. PubMed PMID: 31895433. 7. Peterson AL, DeLine J, Korcarz CE, Dodge AM, and Stein JH. Phenotypic variability in atherosclerosis burden in an old-order Amish family with homozygous sitosterolemia. J Am Coll Cardiol Case Rep 2020;2(4):646-650. PubMed PMID: XXX 8. Enright CJ, Peterson AL, Eickhoff J, and Dodge AM. Statin adherence and LDL-C reduction in a pediatric population. Progress in Pediatr Cardiol. Epub March 5, 2020. 9. Zawacki AW, Enright CJ, Harris RE, Dodge AM, and Peterson AL. Clinician responses to pediatric lipid screens suggestive of severe dyslipidemia. J Pediatr X. Epub autumn 2020. 10. DeFerranti SD, MacRae FL, Knowles JW, Shrader P, Hudgins LC, Benuck I, Kindt I, O’Brien EC, Peterson AL, Ahmad ZS, Clauss S, Duell PB, Shapiro MD, Roe MT, Wilemon K, Gidding SS, and Neal W. Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the CASCADE FH® Registry. J Pediatr. Epub September 23, 2020.	No	Xiao Zhang PhD, xiao.zhang@wisc.edu. Ann Dodge PNP, adodge@uwhealth.org	Impact of COVID-19 on Cardiometabolic Health Parameters in Children: The Pediatric Preventive Cardiology Clinic (PPCC) at American Family Children's Hospital cares for children with risk factors for premature atherosclerotic cardiovascular disease, including abnormal cholesterol. Our team maintains a robust clinical database to aid in this. We have noted that since the onset of COVID-19, many of our patients have struggled to maintain healthy lifestyle choices and consequently have had worsening of their laboratory markers of cardiovascular health, including cholesterol and insulin resistance. We would like to systematically investigate this through a database analysis and chart review. Additionally, any student involved in this project would have the opportunity to attend PPCC at AFCH and take advantage of other clinical opportunities within the division of pediatric cardiology. ____________________________________________________________________________ Role - Collaborate with the PPCC research team to obtain IRB approval, query the PPCC database, conduct limited chart review, and prepare results for abstract and publication. Attend PPCC and other pediatric cardiology clinical cares as desired.; IRB Status - Student will be involved in IRB submission which will take place Jan-April 2021; Skills - None	Mala Peterson, apeterson@pediatrics.wisc.edu -- Co-Mentor: Kristen Marten DO, Assistant Professor of Pediatrics kmarten2@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc6nQefIwA7mMYEuovjhYSJ6fKJCvBXb8e2wMgYmBpXA2lGJh5qwhp08HXZN475hXI
02/12/2020	kli23@wisc.edu	Ke	Li	PhD	Assistant Professor	6.082.624.566	Medical Physics		Radiology		Amy Fowler	AFowler@uwhealth.org	Radiology		Multi-Contrast X-ray Breast Imaging	The overall objective of the project is to develop a multi-contrast x-ray digital mammography prototype imaging system to improve breast cancer detection for women with dense breasts. In this new imaging system, the current x-ray absorption contrast-based mammographic imaging capability will be maintained with the addition of two supplemental contrast mechanisms: the first utilizes a contrast mechanism based on the x-ray refraction property in soft tissue and permits improved visualization of low contrast masses. The detection of microcalcifications can be accomplished by another concomitant novel x-ray dark field contrast mechanism. All three types of images are generated from a single data acquisition. The prototype system has been constructed at our lab and is currently under in vivo human subject evaluation study. The student's role is to help reformat the acquired multi-contrast images to facilitate breast radiologists to perform reader studies. The student will also help perform statistical analysis of the reading results. Photos of the prototype mammography imaging system can be found on the lab website at: https://www.medphysics.wisc.edu/research/ct/li/	1	The student's role is to help processing and reformatting the acquired multi-contrast images to facilitate breast radiologists to perform reader studies. The student will also perform statistical analysis of the reading results.		Basic training in biostatistics and medical imaging	IRB Approved	Yes	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	X Ji, R Zhang, K Li, GH Chen, "Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging," IEEE Transactions on Medical Imaging 39 (11), 3278-3289 (2020) R Zhang, AM Fowler, LG Wilke, F Kelcz, JW Garrett, GH Chen, K Li, "Fast Acquisition with Seamless Stage Translation (FASST) for a trimodal x‐ray breast imaging system. Medical Physics 47 (9), 4356-4362 (2020) K Li, R Zhang, J Garrett, Y Ge, X Ji, GH Chen, "Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system." Proc. SPIE 10573, 105730W (2018) K Li, GH Chen, "X-ray Phase Contrast Tomosynthesis Imaging." Handbook of X-ray Imaging: Physics and Technology	Yes	Ke Li; Amy Fowler	Multi-Contrast X-ray Breast Imaging: The overall objective of the project is to develop a multi-contrast x-ray digital mammography prototype imaging system to improve breast cancer detection for women with dense breasts. In this new imaging system, the current x-ray absorption contrast-based mammographic imaging capability will be maintained with the addition of two supplemental contrast mechanisms: the first utilizes a contrast mechanism based on the x-ray refraction property in soft tissue and permits improved visualization of low contrast masses. The detection of microcalcifications can be accomplished by another concomitant novel x-ray dark field contrast mechanism. All three types of images are generated from a single data acquisition. The prototype system has been constructed at our lab and is currently under in vivo human subject evaluation study. The student's role is to help reformat the acquired multi-contrast images to facilitate breast radiologists to perform reader studies. The student will also help perform statistical analysis of the reading results. Photos of the prototype mammography imaging system can be found on the lab website at: https://www.medphysics.wisc.edu/research/ct/li/ ____________________________________________________________________________ Role - The student's role is to help processing and reformatting the acquired multi-contrast images to facilitate breast radiologists to perform reader studies. The student will also perform statistical analysis of the reading results.; IRB Status - IRB Approved; Skills - Basic training in biostatistics and medical imaging	Ke Li, kli23@wisc.edu -- Co-Mentor: Amy Fowler AFowler@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucT07yizWAVuWHCCElnCKk9l4lKbOMXS3a6yqE8rxUNkjTchk6sHPBIB2VySeRlpeQ
02/12/2020	sehgal@rehab.wisc.edu	Nalini	Sehgal	MD	Associate Professor		Orthopedics and Rehabilitation	Physical Medicine and Rehabilitation							Effects of lumbar medial branch RFN on low back and hip kinematics	One of the goals of interventional pain procedures is to relieve pain or improve a patient’s quality of life. Among the types of procedures, medial branch radiofrequency neurotomy (RFN) is an effective treatment for lumbar zygapophyseal joint pain. The medial branch nerve innervates the zygapophyseal joint and multifidus muscle (MM). Thus, ablating the nerve blocks sensory inputs from the joint and provides pain relief. But, it also disrupts motor inputs to MM and causes MM to atrophy. Since MM extends, flexes, and rotates the spine via its origin from the sacrum and transverse processes of the vertebrae and insertion to the superior vertebrae spinous processes of its origin, unequal exertional load distribution on MM could lead to spinal segment moving out of their normal range of motion and cause tissue injury (1, 2). Patient may be predisposed to long-term pain. To date, there is little information available on the effects of RFN on local and global function of the spine and hip with ambulation. The overall goal of this research is to determine the effects of RFN on gait and community ambulation. The objective for this study is to investigate the effects of RFN on spine and hip kinematics during sit-to-stand/stand-to-sit movements and walking. We hypothesize that patients with facet arthropathy will have improved lumbar extensors muscles strength, spine and hip kinematics, and ambulation after radiofrequency neurotomy.	0	Student will assist with the data collection process. Student will interview subjects and carry out the experimental protocol.		Team player	Pending	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	Not currently available to mentor other students	1. Panjabi MM. Panjabi – 1992 – the stabilizing system of the spine. Part II. Neutral zone and instability hypothesis.pdf. J Spinal Disord 1992;5:390–396. discussion: 397. 2.Panjabi MM. Clinical spinal instability and low back pain. J Electromyogr Kinesiol2003;13:371–379.	Yes	Delilah Kowalke; Phone: (608)263-8642; kowalke@rehab.wisc.edu	Effects of lumbar medial branch RFN on low back and hip kinematics : One of the goals of interventional pain procedures is to relieve pain or improve a patient’s quality of life. Among the types of procedures, medial branch radiofrequency neurotomy (RFN) is an effective treatment for lumbar zygapophyseal joint pain. The medial branch nerve innervates the zygapophyseal joint and multifidus muscle (MM). Thus, ablating the nerve blocks sensory inputs from the joint and provides pain relief. But, it also disrupts motor inputs to MM and causes MM to atrophy. Since MM extends, flexes, and rotates the spine via its origin from the sacrum and transverse processes of the vertebrae and insertion to the superior vertebrae spinous processes of its origin, unequal exertional load distribution on MM could lead to spinal segment moving out of their normal range of motion and cause tissue injury (1, 2). Patient may be predisposed to long-term pain. To date, there is little information available on the effects of RFN on local and global function of the spine and hip with ambulation. The overall goal of this research is to determine the effects of RFN on gait and community ambulation. The objective for this study is to investigate the effects of RFN on spine and hip kinematics during sit-to-stand/stand-to-sit movements and walking. We hypothesize that patients with facet arthropathy will have improved lumbar extensors muscles strength, spine and hip kinematics, and ambulation after radiofrequency neurotomy. ____________________________________________________________________________ Role - Student will assist with the data collection process. Student will interview subjects and carry out the experimental protocol. ; IRB Status - Pending; Skills - Team player	Nalini Sehgal, sehgal@rehab.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucver1bmanKycN_Z_tUtZRMKcMmkSxGNTQIZZVVs8WTWR4EiAgGoRyIo_MbkoGgnAI
02/12/2020	sawells@wisc.edu	Shane	Wells	M.D.	Associate Professor	608	Radiology	Abdominal Imaging							Prostate Magnetic Resonance Elastography: Technical Development and Preclinical Evaluation	Students will assist in the development and validation of a prototype prostate-specific passive driver. Passive driver optimization will be performed in the Brace Lab and validation (prostate phantoms) will be performed in MRI (WIMR). Students will participate in medical device development using basic engineering techniques and the application of image-based biomechanics in the prostate.	0	Students will participate in fabrication and testing (MRI) of the passive driver in a prostate phantom. Students will collect and analyze data under the guidance of the PI (Wells, Brace) and lab manager (White). Students will meet weekly to collaborate and update with team on progress.	Student will collaborate with PIs, lab manager and collaborators on a daily basis.	Intellectual curiosity, Dedication	N/A	No	No (plan to use Dean's Office Funds)	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	PhD students	Tannenbaum A, et al. Effect of metabolic syndrome on anatomy and function of the lower urinary tract. (in preparation) Target Journal: Abdominal Radiology Anzia LE, et al.Comprehensive non-invasive analysis of lower urinary tract anatomy using MRI. Abdom Radiol 2020. PMID: 33040167	Yes	Christopher L. Brace, Jim White	Prostate Magnetic Resonance Elastography: Technical Development and Preclinical Evaluation: Students will assist in the development and validation of a prototype prostate-specific passive driver. Passive driver optimization will be performed in the Brace Lab and validation (prostate phantoms) will be performed in MRI (WIMR). Students will participate in medical device development using basic engineering techniques and the application of image-based biomechanics in the prostate. ____________________________________________________________________________ Role - Students will participate in fabrication and testing (MRI) of the passive driver in a prostate phantom. Students will collect and analyze data under the guidance of the PI (Wells, Brace) and lab manager (White). Students will meet weekly to collaborate and update with team on progress.; IRB Status - N/A; Skills - Intellectual curiosity, Dedication	Shane Wells, sawells@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuerNbeRemPpcwxOPixNKgKVb8MGm1ZGYHWIhI8Ms5Ya1f8YJ39IggYCi9XiaC--RVc
02/12/2020	sawells@wisc.edu	Shane	Wells	M.D.	Associate Professor	608	Radiology	Abdominal Imaging							Effect of metabolic syndrome on prostate perfusion	Students will use commercially available post-processing software to analyze bladder wall volume, post void residual, prostate size/volume (whole prostate, transition zone) and perfusion kinetics of the periurethral transition zone from pelvic MRIs. Students will assist with limited chart review (demographic and clinical information - metabolic syndrome, LUTS scores). Students will formally meet with our collaborative team weekly. The mentor (Wells) will teach the students how to review MRI and collaborators will teach students to use post-processing software.	0	Student will lead the project and utilize collaborators for learning, data collection and analysis, as needed.	Students will become increasingly independent during the program	Intellectual curiosity, Dedication	IRB approved	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Anzia LE, et al. Comprehensive non-invasive analysis of lower urinary tract anatomy using MRI. Abdom Radiol 2020. PMID: 33040167 Tennenbaum A, et al. Effect of metabolic syndrome on anatomy and function of the lower urinary tract. (in preparation) Target Journal: Abdom Radiol	Yes	Alejo Roldan-Azate	Effect of metabolic syndrome on prostate perfusion: Students will use commercially available post-processing software to analyze bladder wall volume, post void residual, prostate size/volume (whole prostate, transition zone) and perfusion kinetics of the periurethral transition zone from pelvic MRIs. Students will assist with limited chart review (demographic and clinical information - metabolic syndrome, LUTS scores). Students will formally meet with our collaborative team weekly. The mentor (Wells) will teach the students how to review MRI and collaborators will teach students to use post-processing software. ____________________________________________________________________________ Role - Student will lead the project and utilize collaborators for learning, data collection and analysis, as needed.; IRB Status - IRB approved; Skills - Intellectual curiosity, Dedication	Shane Wells, sawells@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuek9yn69IS12SfO94AmZX_zUgh4l2NuGnzZ2wAdYgr3sjwgeJv-B3wpXKLlROFE6jU
22/12/2020	richardsk@urology.wisc.edu	Kyle	Richards	MD FACS	Assistant Professor	6.089.603.337	Urology								Urologic Surgery Health Services Research	I have been working with medical students via the Shapiro program for 5 consecutive years. My goal is to train future leaders in medicine and we tailor the research to fit the goals of the student. I also enjoy getting the students in the operating room once a week to view robotic surgery. I work with a research team that includes project coordinators, research assistants, and biostatisticians. If student researchers are allowed to see patients again, one of our projects is a clinical trial evaluating the utility of pre-procedure urine testing in patient's presenting to the urology clinic for office procedures. The student, if interested, would assist the research team in enrolling patients, consenting patients, collecting data, and performing follow-up interviews with the patients. If the student prefers more of a big data type project, we also have large nationwide databases using VA data for patients with prostate or bladder cancer. One specific project is looking at the impact of Agent Orange (a known carcinogen that Veterans may have been exposed to in Vietnam) on bladder cancer outcomes. If the student is interested in this type of work, they would get to prepare a manuscript from this dataset from start to finish. Lastly, we are actively building a Wisconsin Bladder Cancer Network to engage a group of patients with bladder cancer to assist the research team in identifying patient-centered research priorities. The student would assist the research team in facilitation of focus groups with this engaged cohort as well as compilation and analysis of data from surveys that were sent to patients with bladder cancer. https://urology.wisc.edu/blog/staff/richards-md-facs-kyle-a/	0	Assist the research team on the project of their choosing.	Moderate	Committed and enthusiastic	All projects listed are either approved or exempt	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	https://pubmed.ncbi.nlm.nih.gov/?cmd=Search&term=Richards+KA%5BAuthor%5D	Yes	Denise Mussehl	Urologic Surgery Health Services Research: I have been working with medical students via the Shapiro program for 5 consecutive years. My goal is to train future leaders in medicine and we tailor the research to fit the goals of the student. I also enjoy getting the students in the operating room once a week to view robotic surgery. I work with a research team that includes project coordinators, research assistants, and biostatisticians. If student researchers are allowed to see patients again, one of our projects is a clinical trial evaluating the utility of pre-procedure urine testing in patient's presenting to the urology clinic for office procedures. The student, if interested, would assist the research team in enrolling patients, consenting patients, collecting data, and performing follow-up interviews with the patients. If the student prefers more of a big data type project, we also have large nationwide databases using VA data for patients with prostate or bladder cancer. One specific project is looking at the impact of Agent Orange (a known carcinogen that Veterans may have been exposed to in Vietnam) on bladder cancer outcomes. If the student is interested in this type of work, they would get to prepare a manuscript from this dataset from start to finish. Lastly, we are actively building a Wisconsin Bladder Cancer Network to engage a group of patients with bladder cancer to assist the research team in identifying patient-centered research priorities. The student would assist the research team in facilitation of focus groups with this engaged cohort as well as compilation and analysis of data from surveys that were sent to patients with bladder cancer. https://urology.wisc.edu/blog/staff/richards-md-facs-kyle-a/ ____________________________________________________________________________ Role - Assist the research team on the project of their choosing.; IRB Status - All projects listed are either approved or exempt; Skills - Committed and enthusiastic	Kyle Richards, richardsk@urology.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuemYYQ3r3qdcTS_-8v7Sd2aaT2QdYNW88wSIsPqeXGZONb95lOXMeGiHD5zpcqGorI
04/12/2020	mcguine@ortho.wisc.edu	Tim	McGuine	PhD	Distinguished Scientist	6.082.656.516	Orthopedics and Rehabilitation	Sports Medicine							The Impact of Restarting High School Sports on The Health of High School Athletes	Background: High school athletics play an important role in improving the short and long term health of US student athletes. In an effort to spread to slow the spread of COVID-19, US high schools were closed to in person teaching and interscholastic athletics were cancelled. Our research shows that these closures and cancellations are associated with significant negative impacts on the health and well-being of interscholastic athletes. To date, these is no evidence to show how opening schools and restarting high school sports has improved the health and well-being of high school student athletes. Objectives: To document how restarting in person teaching and interscholastic sports has improved the mental and physical health as well as the quality of life of high school athletes. Methods: Potential participants (high school student athletes) will be recruited via social media and email solicitation in May 2021 to complete a web based (Qualtrics) survey when schools and sports are in session. Emphasis will be made to match (age, sex, grade, sports played, school size, state and county location) the population of this study with the subjects in the May 2020 cohort. Data analyses: Demographic variables and individual sport participation will be summarized (mean (SD)or N (%)) overall and by study group (May 2020 cohort and reopening school cohort) stratified by sex. Univariable comparisons of these variables between the two groups will be made via t-tests or chi square tests. Means and 95% confidence intervals (CI) for each group will be estimated by survey weighted ANOVA models separately for the mental health, physical activity and quality of life measures to compare the scores between both groups. Anticipated results: We anticipate that our results will show student athletes competing in interscholastic athletics during the 2020/21 school year will have improved health (a lower prevalence of mental health disorders, increased physical activity levels and improved health related quality of life) compared to high school athletes in May 2020 when high school interscholastic sports were cancelled. Stakeholder impact: This study is vitally important at this time because it can illustrate how high school sport participation improves the health of student athletes who are already coping with the COVID-19 pandemic.	0	1) Querying and entering data into the database, 2) Accessing individual US county and state poverty level data 3) Summarizing and producing state level and national data reports, 4) Assisting with abstract and manuscript production	Moderate	Data entry, Spread sheet maintenance, ability to learn to work within a research team	Approved: HS IRB #: 2020-0981	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	DPT students, MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	1) McGuine TA, Biese K, Petrovska L, Hetzel S, Reardon C, Kliethermes S, Bell D, Brooks MA & Watson A. The Health Of US Adolescent Athletes During Covid-19 Related School Closures And Sport Cancellations Journal of Athletic Training (2020) https://doi.org/10.4085/478-20. 2) McGuine TA, Biese K, Petrovska L, Hetzel S, Reardon C, Kliethermes S, Bell D, Brooks MA & Watson A. The Impact of COVID-19 Related School Closures and Sport Cancellations on the Health of Adolescent Athletes (under review)	Yes	Heidi Ableidinger (email: Ableidinger@ortho.wisc.edu)	The Impact of Restarting High School Sports on The Health of High School Athletes: Background: High school athletics play an important role in improving the short and long term health of US student athletes. In an effort to spread to slow the spread of COVID-19, US high schools were closed to in person teaching and interscholastic athletics were cancelled. Our research shows that these closures and cancellations are associated with significant negative impacts on the health and well-being of interscholastic athletes. To date, these is no evidence to show how opening schools and restarting high school sports has improved the health and well-being of high school student athletes. Objectives: To document how restarting in person teaching and interscholastic sports has improved the mental and physical health as well as the quality of life of high school athletes. Methods: Potential participants (high school student athletes) will be recruited via social media and email solicitation in May 2021 to complete a web based (Qualtrics) survey when schools and sports are in session. Emphasis will be made to match (age, sex, grade, sports played, school size, state and county location) the population of this study with the subjects in the May 2020 cohort. Data analyses: Demographic variables and individual sport participation will be summarized (mean (SD)or N (%)) overall and by study group (May 2020 cohort and reopening school cohort) stratified by sex. Univariable comparisons of these variables between the two groups will be made via t-tests or chi square tests. Means and 95% confidence intervals (CI) for each group will be estimated by survey weighted ANOVA models separately for the mental health, physical activity and quality of life measures to compare the scores between both groups. Anticipated results: We anticipate that our results will show student athletes competing in interscholastic athletics during the 2020/21 school year will have improved health (a lower prevalence of mental health disorders, increased physical activity levels and improved health related quality of life) compared to high school athletes in May 2020 when high school interscholastic sports were cancelled. Stakeholder impact: This study is vitally important at this time because it can illustrate how high school sport participation improves the health of student athletes who are already coping with the COVID-19 pandemic. ____________________________________________________________________________ Role - 1) Querying and entering data into the database, 2) Accessing individual US county and state poverty level data 3) Summarizing and producing state level and national data reports, 4) Assisting with abstract and manuscript production; IRB Status - Approved: HS IRB #: 2020-0981; Skills - Data entry, Spread sheet maintenance, ability to learn to work within a research team	Tim McGuine, mcguine@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueMBJFWl-Ji1nnbcDcnzLwdBupBTuxp9UhvNevPNM7PnPkDBLdgHclG7fxDquV3YDw
04/01/2021	amparkes@medicine.wisc.edu	Amanda	Parkes	MD	Assistant Professor		Oncology	Hematology, Medical Oncology and Palliative Care							Assessing Care of Adolescents and Young Adults with Cancer at the University of Wisconsin	This project is designed to help us better understand the adolescent and young adult (AYA) population being cared for at the University of Wisconsin, as well as areas for care improvement. AYA patients (ages 15-39) with cancer are a unique population, with their own diagnoses, complications, morbidities, and psychosocial concerns distinct from their peers and cancer patients in other age groups. These patients face challenges related to work, school, health insurance, relationships, sexuality and fertility, as well as emotional distress and depression. These unique needs necessitate clear documentation of items such as discussion of fertility preservation, as well as involvement with multiple other disciplines including social work, case management, psychology, child life, pain and palliative care, occupational and physical therapy, nutrition, and genetics. Despite this recognition and multiple guidelines supporting these needs, there is limited data regarding the care of AYA patients prior to the implementation of AYA programs. This project would identify AYA patients who have received cancer care at the University of Wisconsin and allow for baseline assessment of resource and specialist utilization. We would use both retrospective chart review as well as patient and provider surveys to identify characteristics that affect care of AYA patients with cancer at UW. While we would expect publication based on compilation of this baseline data, we will ultimately plan to compare this baseline data with post-intervention data following implementation of an AYA program at the University of Wisconsin. Areas for care improvement identified by this project would be considered in the UW AYA Oncology Program, which is expected to start in early 2021.	0	The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript.	High	Required skills include: literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing.	This project is IRB exempt.	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	DPT students, MPH students, PhD students	McKay G, Zakas AL, Osman F, Lee-Miller C, Pophali P, Parkes A. Disparities Between Provider Assessment and Documentation of Care Needs in the Care of Adolescent and Young Adult Patients with Sarcoma. Manuscript under review at Journal of Oncology Practice. Work presented at ASCO Quality Care Symposium; Virtual Event; October 2020. McKay G, Zakas AL, Osman F, Parkes A. Factors Affecting Genetic Consultation in Adolescent and Young Adult Patients with Sarcoma. Manuscript under review at Journal of the National Comprehensive Cancer Network. Work presented at Connective Tissue Oncology Society; Virtual Event; November 2020.	Yes	Julene Gaspard	Assessing Care of Adolescents and Young Adults with Cancer at the University of Wisconsin: This project is designed to help us better understand the adolescent and young adult (AYA) population being cared for at the University of Wisconsin, as well as areas for care improvement. AYA patients (ages 15-39) with cancer are a unique population, with their own diagnoses, complications, morbidities, and psychosocial concerns distinct from their peers and cancer patients in other age groups. These patients face challenges related to work, school, health insurance, relationships, sexuality and fertility, as well as emotional distress and depression. These unique needs necessitate clear documentation of items such as discussion of fertility preservation, as well as involvement with multiple other disciplines including social work, case management, psychology, child life, pain and palliative care, occupational and physical therapy, nutrition, and genetics. Despite this recognition and multiple guidelines supporting these needs, there is limited data regarding the care of AYA patients prior to the implementation of AYA programs. This project would identify AYA patients who have received cancer care at the University of Wisconsin and allow for baseline assessment of resource and specialist utilization. We would use both retrospective chart review as well as patient and provider surveys to identify characteristics that affect care of AYA patients with cancer at UW. While we would expect publication based on compilation of this baseline data, we will ultimately plan to compare this baseline data with post-intervention data following implementation of an AYA program at the University of Wisconsin. Areas for care improvement identified by this project would be considered in the UW AYA Oncology Program, which is expected to start in early 2021. ____________________________________________________________________________ Role - The student will be responsible for primary data analysis, literature review, and manuscript preparation. Student will be co-mentored by a team of medical oncologists with a focus on both the care of adolescent and young adults with cancer as well as survivorship issues following cancer treatment. The student will also have opportunities to spend time in cancer clinics and participate in publication of a manuscript. ; IRB Status - This project is IRB exempt. ; Skills - Required skills include: literature review, electronic medical record abstraction, basic statistical skills (or interest in honing such skills), manuscript writing.	Amanda Parkes, amparkes@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucmnOgK1gjD2kN7nrCzc_tF4L87shTClm0NcMYMoJFQ0e_859SjDLeRY9kvYRCP2eU
07/12/2020	dempsey@neurosurgery.wisc.edu	Robert	Dempsey	MD	Professor & Chairman	608	Neurological Surgery				Carol Mitchell, PhD	ccm@medicine.wisc.edu	Medicine	Cardiovascular	Stroke Prevention in the Native American Population - the Oneida Nation	American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes than compared to US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will examine how novel ultrasound biomarkers are related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population.	0	MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - including risk assessment, learning about imaging and cognitive methods - if on-site activities are permitted, if not these activities will be virtual. Furthermore, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation		Curious / multitasking / willing to learn new skills / teamwork	IRB approved 2019-1550	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	1. Harris R, Nelson LA, Muller C, Buchwald D. Stroke in American Indians and Alaska Natives: A Systematic Review. Am J Public Health. 2015;105(8):e16-e26. doi:10.2105/AJPH.2015.302698. 2. Great Lakes Inter-Tribal Council, Inc. Burden of Cardiovascular Disease among American Indians and Alaska Natives in Wisconsin. Lac du Flambeau, WI: Great Lakes Inter-Tribal Epidemiology Center, Great Lakes Inter-Tribal Council, Inc.; 2015. 3. Yuan H, White C, and Petillo F. The Burden of Heart Disease and Stroke in Wisconsin 2010. Wisconsin Heart Disease and Stroke Prevention Program, Wisconsin Department of Health Services. P-00146 (02/10). 4. Dempsey RJ, Jackson DC, Wilbrand SM, et al. The Preservation of Cognition 1 Year After Carotid Endarterectomy in Patients With Prior Cognitive Decline. Neurosurgery 2018; 82: 322-328. 2017/06/03. DOI: 10.1093/neuros/nyx173. 5. Dempsey RJ, Varghese T, Jackson DC, et al. Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis. J Neurosurg 2018; 128: 111-119. 2017/03/17. DOI: 10.3171/2016.10.JNS161299. 6. Dempsey RJ, Vemuganti R, Varghese T, et al. A Review of Carotid Atherosclerosis and Vascular Cognitive Decline. Neurosurgery 2010; 67: 484-494. 2010/07/21. DOI: 10.1227/01.Neu.0000371730.11404.36. 7. Mitchell CC, Stein JH, Cook TD, et al. Histopathologic Validation of Grayscale Carotid Plaque Characteristics Related to Plaque Vulnerability. Ultrasound in medicine & biology 2017; 43: 129-137. 2016/10/11. DOI: 10.1016/j.ultrasmedbio.2016.08.011. 8. Mitchell CC, Wilbrand SM, Kundu B, et al. Transcranial Doppler and Microemboli Detection: Relationships to Symptomatic Status and Histopathology Findings. Ultrasound in medicine & biology 2017; 43: 1861-1867. 2017/06/25. DOI: 10.1016/j.ultrasmedbio.2017.04.025. 9. Meshram NH, Jackson D, Varghese T, et al. A Cross-Sectional Investigation of Cognition and Ultrasound-Based Vascular Strain Indices. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2019 2019/02/26. DOI: 10.1093/arclin/acz006. 10. Meshram NH, Varghese T, Mitchell CC, et al. Quantification of carotid artery plaque stability with multiple region of interest based ultrasound strain indices and relationship with cognition. Phys Med Biol 2017; 62: 6341-6360. 2017/06/09. DOI: 10.1088/1361-6560/aa781f. 11. Wesley UV, Hatcher JF, Ayvaci ER, Klemp A, Dempsey RJ. Regulation of Dipeptidyl Peptidase IV in the Post-stroke Rat Brain and In Vitro Ischemia: Implications for Chemokine-Mediated Neural Progenitor Cell Migration and Angiogenesis. Mol Neurobiol. 2017 Sep;54(7):4973-4985. Epub 2016 Aug 15. PMID:27525674. PMCID: PMC5985827. 12. Amersfoort J, Schaftenaar FH, Douna H, van Santbrink PJ, Kröner MJ, van Puijvelde GHM, Quax PHA, Kuiper J, Bot I. Lipocalin-2 contributes to experimental atherosclerosis in a stage- dependent manner. Atherosclerosis. 2018 Jun 13;275:214-224. [Epub ahead of print] PMID:29960897. 13. Hochmeister S, Engel O, Adzemovic MZ, Pekar T, Kendlbacher P, Zeitelhofer M, Haindl M, Meisel A, Fazekas F, Seifert-Held T. Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke. PLoS One. 2016 May 6;11(5):e0154797. PMID:27152948. PMCID: PMC4859492. 14. Greenland S, Lanes S, Jara M. Estimating effects from randomized trials with discontinuations: the need for intent-to-treat design and G-estimation. Clinical Trials 2008;5(1):5-13. Doi: 10.1177/1740774507087703. PMID: 18283074.	Yes	Stephanie Wilbrand, PhD - wilbrand@neurosurgery.wisc.edu - handles all administrative work for this project for Dr. Dempsey as well as acts as another mentor	Stroke Prevention in the Native American Population - the Oneida Nation: American Indian/Alaska Native (AI/AN) populations across the country experiences some of the highest disparities in health and socioeconomic factors compared to other US populations. Native communities are disproportionately affected with elevated rates of obesity, diabetes, alcohol abuse, cigarette smoking, poverty, and the second lowest rates of educational attainment [1]. These include major risk factors for cerebrovascular disease. It has been found that Native people have a 14% higher mortality rate from strokes than compared to US populations [2]. A geographic disparity has also been found to exist in AI/AN populations in the US with regards to mortality rates due to stroke. Native populations in the northern states have higher mortality rates from strokes than do populations in the southern states, with Native populations in Wisconsin experiencing some of the highest mortality rates [2]. The Oneida Nation has previously listed in the 2014-2016 Community Health Improvement Plan (CHIP) that their two top priority areas were to reduce tribal member obesity rates and to improve the quality of diabetes care to tribal members. Obesity and diabetes, in addition to hypertension, dyslipidemia, smoking, decreased physical activity, history of vascular disease and/or heart disease and diet are all risk factors that can be controlled or treated to decrease the risk for stroke. In Native American populations, stroke as well as premature dementia are two of the greatest causes of disability and death [2,3]. Individuals at high risk for stroke are also at high risk for vascular cognitive decline and dementia. Carotid atherosclerosis is a risk factor for both stroke and vascular cognitive decline and dementia. Carotid atherosclerosis is thought to contribute to stroke and vascular dementia through mechanisms of ischemia and the release of microemboli due to plaque instability. Ischemia results from plaque in the arterial wall causing narrowing of the carotid artery lumen and thus decreasing blood flow to the brain. [4-10] Plaque instability is thought to contribute to stroke risk and vascular dementia through the release of microemboli. Thus, it is important to identify individuals at highest risk for this disease, identify how to reduce/modify risk factors for this disease and optimize treatment of this disease for individuals. [4-10] This proposal will examine how novel ultrasound biomarkers are related to stroke risk factors and how interventions such as health education and coaching can contribute to reducing these risk factors and the incidence of stroke in the Native American population. ____________________________________________________________________________ Role - MD student role is to actively participate in the stroke prevention community program at the Oneida Nation - including risk assessment, learning about imaging and cognitive methods - if on-site activities are permitted, if not these activities will be virtual. Furthermore, this project will involve data collection and analysis, literature review, observing outreach activities for the Oneida Nation; IRB Status - IRB approved 2019-1550; Skills - Curious / multitasking / willing to learn new skills / teamwork	Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Carol Mitchell, PhD ccm@medicine.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue0HWTAqkK6h-Eql0A8VEfJM-s2HeECpxE63kAPAit9bvJEzFyvOzt_0l_NQ9s0fu8
10/12/2020	ceg@medicine.wisc.edu	Carey	Gleason	PhD in Clinical Neuropsychology	Assistant Professor	6.082.561.901	Medicine	Geriatrics							Alzheimer's Disease Research Center's Inclusion of Under-Represented Groups Core	Student will work with Gleason lab projects related to Alzheimer's disease and Related Dementias in American Indian and African American research participants. Projects could include working with existing datasets, literature review, community-based participatory research activities, and similar.	0	would like student to lead a project.	being to intermediate	interest in working with groups under-represented in ADRD research.	approved.	Yes	No (plan to use Dean's Office Funds)	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students	https://www.ncbi.nlm.nih.gov/myncbi/carey.gleason.1/bibliography/public/	Yes	Carola Ferrer Simo, Hector Salazar, Fabu Carter, Toni Hofnine	Alzheimer's Disease Research Center's Inclusion of Under-Represented Groups Core: Student will work with Gleason lab projects related to Alzheimer's disease and Related Dementias in American Indian and African American research participants. Projects could include working with existing datasets, literature review, community-based participatory research activities, and similar. ____________________________________________________________________________ Role - would like student to lead a project.; IRB Status - approved.; Skills - interest in working with groups under-represented in ADRD research.	Carey Gleason, ceg@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufmyFDyfkOlbiqLnjKIE-k4bsIP4GjZv0hTdRrhPATAzn2N8s-vQT3u3pf5bdjgF3I
10/12/2020	rcoller@pediatrics.wisc.edu	Ryan	Coller	MD, MPH	Kok-Peng Yu and Anna Lee Shen Assistant Professor of Pediatrics, Division Chief	608	Pediatrics	Hospital Medicine			Mary Ehlenbach, O'Conner Family Associate Professor	mehlenbach@pediatrics.wisc.edu	Pediatrics	Hospital Medicine	Caregiving Networks and Neighborhood Disadvantage for Children with Medical Complexity	This social network analysis pilot study project will enroll primary caregivers (i.e., parents) and secondary caregivers (i.e., extended family, home and school nurses, and other caregivers) of children with medical complexity. Each caregiver in a child's caregiving will answer survey questions to describe the connections within their network. We will analyze the various caregiving network structures, strengths/weaknesses, and identify associations between network characteristics and health services outcomes. By enrolling families from diverse neighborhoods we will also attempt to characterize how caregiving networks differ between children from more and less disadvantage neighborhoods. (https://www.pediatrics.wisc.edu/hospital-medicine-and-complex-care-research-program/)	0	With guidance for social network analysis and health services mentors, contribute to the design of the survey instrument. Assist in recruiting and consenting primary and secondary caregivers. Conduct data collection through telephone or in-person interviews. Participate in analyses and interpretation with guidance from mentors. Present findings to research team. Work as a member of a collaborative multi-disciplinary team.	Moderate - self-direct daily work with guidance, support, a clear timeline and deliverables	Comfort with Microsoft Office. Experience with clinical research (quantitative or qualitative) is desired. Organizational skills and positive attitude are important.	Will be obtained prior	Yes	Department of Pediatrics will provide support	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, UW undergraduates interested in research	https://pubmed.ncbi.nlm.nih.gov/?term=coller+rj&sort=date	Yes	Gemma Warner (gwarner@pediatrics.wisc.edu); Kim Stevenson (kdstevenson@pediatrics.wisc.edu)	Caregiving Networks and Neighborhood Disadvantage for Children with Medical Complexity: This social network analysis pilot study project will enroll primary caregivers (i.e., parents) and secondary caregivers (i.e., extended family, home and school nurses, and other caregivers) of children with medical complexity. Each caregiver in a child's caregiving will answer survey questions to describe the connections within their network. We will analyze the various caregiving network structures, strengths/weaknesses, and identify associations between network characteristics and health services outcomes. By enrolling families from diverse neighborhoods we will also attempt to characterize how caregiving networks differ between children from more and less disadvantage neighborhoods. (https://www.pediatrics.wisc.edu/hospital-medicine-and-complex-care-research-program/) ____________________________________________________________________________ Role - With guidance for social network analysis and health services mentors, contribute to the design of the survey instrument. Assist in recruiting and consenting primary and secondary caregivers. Conduct data collection through telephone or in-person interviews. Participate in analyses and interpretation with guidance from mentors. Present findings to research team. Work as a member of a collaborative multi-disciplinary team.; IRB Status - Will be obtained prior; Skills - Comfort with Microsoft Office. Experience with clinical research (quantitative or qualitative) is desired. Organizational skills and positive attitude are important.	Ryan Coller, rcoller@pediatrics.wisc.edu -- Co-Mentor: Mary Ehlenbach, O'Conner Family Associate Professor mehlenbach@pediatrics.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufgIBK0vUIvVUk3h2fgAKTGdV6-ck8bDZaNgYQRGmmnEobFQBKv_jtq80l0oAm9t6A
11/12/2020	mwharer@wisc.edu	Matthew	Harer	MD	Assistant Professor of Neonatology	608	Pediatrics	Neonatology							Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU	This project will involve two different types of research. Prospective recruitment for an ongoing clinical trial in the NICU and a chart review/analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. https://www.pediatrics.wisc.edu/research/research-groups/harer/	0	The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad.	This project will be flexible with time requirements. Students will work closely with a Neonatal Fellow and Assistant Professor Attending, meeting multiple times per week. The student will also have the opportunity to shadow in the NICU.	None - Interest in Pediatrics or Neonatology preferred	Approved	Wisconsin Partnership Program; ICTR KL2 Pending	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	UW undergraduates interested in research	1. Harer MW, Adegboro, CO, Richard, L, McAdams, RM. Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury. Pediatr Nephrol. 2020. Published online. 2. Harer MW, Chock VY. Renal Tissue Oxygenation Monitoring-An Opportunity to Improve Kidney Outcomes in the Vulnerable Neonatal Population. Front Pediatr. 2020;8:241. PMID: 32528917; PMCID: PMC7247835. 3. Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study. JAMA Pediatr. 2018 Jun 4;172(6):e180322. PMID: 29610830; PMCID: PMC6137530. 4. Harer MW, Charlton JR, Tipple TE, Reidy KJ. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes. J Perinatol. 2020 Apr 10; PMID: 32277164. 5. Harer MW, Pope CF, Conaway MR, Charlton JR. Follow-up of Acute kidney injury in Neonates during Childhood Years (FANCY): a prospective cohort study. 2017 Jun;32(6):1067-1076. PMID: 28255805.	No	N/A	Near Infrared Spectroscopy and tissue oxygenation to diagnose Acute Kidney Injury in premature neonates in the NICU: This project will involve two different types of research. Prospective recruitment for an ongoing clinical trial in the NICU and a chart review/analysis of previously collected data on renal and cerebral tissue oxygenation with NIRS in 35 preterm patients. The goal of the project is to determine if AKI can be detected with NIRS and how other NICU factors affect both cerebral and renal tissue oxygenation. https://www.pediatrics.wisc.edu/research/research-groups/harer/ ____________________________________________________________________________ Role - The Shapiro research student will be asked to review the IRB for this study, become CITI trained, learn the consent process, participate in consent of subjects, develop an electronic database and perform a chart review on enrolled patients and learn basic statistical skills to be performed on Graphpad.; IRB Status - Approved; Skills - None - Interest in Pediatrics or Neonatology preferred	Matthew Harer, mwharer@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudwfXRj091MqalTIQSJ7ewpOTG71er-bSJHEdtSs-85oUXLcQ6_OrltdmRsCMR135g
12/12/2020	spiker@ortho.wisc.edu	Andrea	Spiker	M.D.	Assistant Professor, Orthopedic Surgery	6.082.346.716	Orthopedics and Rehabilitation	Sports Medicine	Other	Hip Preservation					How symmetric are hip preservation patients?	We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who have been seen and evaluated by a Hip Preservation surgeon (for non-arthritic hip pain). We will look at patients with the diagnosis of femoroacetabular impingement (FAI) and hip dysplasia and analyze patient characteristics, radiographic parameters, and clinical examination and surgical course to answer the questions: 1) how symmetric are FAI and dysplastic patients from one hip to the other when it comes to presence/absence of symptoms, degrees of symptoms, radiographic parameters?; 2) of patients who are asymmetric in terms of symptoms, how may go on to develop symptoms in the contralateral hip (and at what time interval)?; 3) is there a difference in symmetry between FAI and dysplastic patients?; 4) of those who have surgery on both hips, how symmetric are the intra-articular findings at the time of surgery?; 5) is there a difference in the PROs of patients who are symmetric versus asymmetric at the time of presentation? I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (FAI and dysplasia) to have a more complete understanding of the importance of this study.	0	A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects.	Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience.	Excel and Word. Organizational skills and good communication with the other members of the team.	IRB application underway.	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	This would be a stand-alone project, so no related publications exist. The idea would be for the student to complete and be a published author on this project.	Yes	Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator	How symmetric are hip preservation patients? : We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who have been seen and evaluated by a Hip Preservation surgeon (for non-arthritic hip pain). We will look at patients with the diagnosis of femoroacetabular impingement (FAI) and hip dysplasia and analyze patient characteristics, radiographic parameters, and clinical examination and surgical course to answer the questions: 1) how symmetric are FAI and dysplastic patients from one hip to the other when it comes to presence/absence of symptoms, degrees of symptoms, radiographic parameters?; 2) of patients who are asymmetric in terms of symptoms, how may go on to develop symptoms in the contralateral hip (and at what time interval)?; 3) is there a difference in symmetry between FAI and dysplastic patients?; 4) of those who have surgery on both hips, how symmetric are the intra-articular findings at the time of surgery?; 5) is there a difference in the PROs of patients who are symmetric versus asymmetric at the time of presentation? I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (FAI and dysplasia) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB application underway.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team.	Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufiDRNOBKQuQsi4AJGvpidFN84RWRCjXRvp_2EWLH9SSvDVAG7Qn0psWcRZemJ3gu4
12/12/2020	sparajuli@medicine.wisc.edu	Sandesh	Parajuli	MD	Assistant Profesor	6.082.650.152	Medicine	Nephrology -Transplant		Transplant					Incidence, risk factors and outcomes of hip and knee replacement after kidney transplantation	There is a huge debate about the timing of hip and knee replacement surgery among patients with ESRD. Liberman et al (PMID: 7798100) recommended Hip replacement should be reserved for patients with CKD/ESRD after transplant only. While other study (PMID: 30634487) suggest risk of AKI is high after hip replacement and arthoplasty. so in this observational study, we would like to present UW data about risk of hip and knee replacement among pt with kidney transplant recipients.	0	student will lead the project, and will help with literature search, data analysis and writing. Will submit abstract for American Society of Nephrology (ASN) and write a paper- as a first author.	Full with guidance	Basic, expect to bring energy and enthusiasms. In last 3 years, I have supervised 6 medical students in the Shapiro projects and all have presented their work in ASN, and 4 have already published paper as a first author and one is under review.	Pending, will be approved soon	Not for this project, but have one ongoing industry funded project	likely from Dept of medicine	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students, Will have other ongoing opportunities if interested- eg. writing a review articles, etc	Not currently available to mentor other students	PMID: 30634487;PMID: 7798100	Yes	N/A	Incidence, risk factors and outcomes of hip and knee replacement after kidney transplantation: There is a huge debate about the timing of hip and knee replacement surgery among patients with ESRD. Liberman et al (PMID: 7798100) recommended Hip replacement should be reserved for patients with CKD/ESRD after transplant only. While other study (PMID: 30634487) suggest risk of AKI is high after hip replacement and arthoplasty. so in this observational study, we would like to present UW data about risk of hip and knee replacement among pt with kidney transplant recipients. ____________________________________________________________________________ Role - student will lead the project, and will help with literature search, data analysis and writing. Will submit abstract for American Society of Nephrology (ASN) and write a paper- as a first author. ; IRB Status - Pending, will be approved soon ; Skills - Basic, expect to bring energy and enthusiasms. In last 3 years, I have supervised 6 medical students in the Shapiro projects and all have presented their work in ASN, and 4 have already published paper as a first author and one is under review.	Sandesh Parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueBbOjNiS-ChK75PS7vnNe-JTl_QVof0cB87aINAdo_-W64EGQmC66qwadRIId3vNo
12/12/2020	sparajuli@medicine.wisc.edu	sandesh	parajuli	MD	Assistant Professor	6.082.650.152	Medicine	Nephrology		Transplant					Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on the donor characteristics	BK viremia is a common infection among kidney transplant recipients. At UW, approx 35% of kidney recipients develop this infection. There is no effective antiviral therapy for this infection. Most of the studies in this field to identify the risk of BK viremia are focused on the recipients. In this study, we would like to identify some of the donor characteristics. For this all deceased donor kidney only recipients will be included if we at UW transplanted both of those kidneys to the two different donors here at UW- and patients will be divided into three groups to identify the risk- group 1 as control, if none of the two recipients develop BK viremia; group 2- if one of the two recipients develop BK viremia and group 3- if both recipients develop BK viremia.	0	Student will lead this project, and will help in the literature search, will collect some data, and prepare abstract and manuscript.	Full with guidance	Basic, just need energy and enthusiasms. I have mentored 6 shapiro students in last 3 years, and all of them have presented their work in the American Society of Nephrology (ASN) and 4 have already published ( as first author)and one is under review	pending, will be approved soon.	Industry sponsored study is ongoing, but not relevant to this project.	likely through Dept of medicine	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students, May be ongoing projects in the future.	Not currently available to mentor other students	PMID: 25498070; PMID: 31399166; PMID: 30746369	Yes	N/A	Risk factors and outcomes of BK viremia among deceased donor kidney transplant recipients based on the donor characteristics : BK viremia is a common infection among kidney transplant recipients. At UW, approx 35% of kidney recipients develop this infection. There is no effective antiviral therapy for this infection. Most of the studies in this field to identify the risk of BK viremia are focused on the recipients. In this study, we would like to identify some of the donor characteristics. For this all deceased donor kidney only recipients will be included if we at UW transplanted both of those kidneys to the two different donors here at UW- and patients will be divided into three groups to identify the risk- group 1 as control, if none of the two recipients develop BK viremia; group 2- if one of the two recipients develop BK viremia and group 3- if both recipients develop BK viremia. ____________________________________________________________________________ Role - Student will lead this project, and will help in the literature search, will collect some data, and prepare abstract and manuscript. ; IRB Status - pending, will be approved soon. ; Skills - Basic, just need energy and enthusiasms. I have mentored 6 shapiro students in last 3 years, and all of them have presented their work in the American Society of Nephrology (ASN) and 4 have already published ( as first author)and one is under review	sandesh parajuli, sparajuli@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufBknB8t5WGEysvwx6-DM9uhntMaI9mpkEh8wUgftmsfOx7O5sNcuNsT-UjEhbcAIc
14/12/2020	bpatter@medicine.wisc.edu	Brian	Patterson	MD MPH	Assisant Professor	3.126.366.957	Emergency Medicine		Biostatistics and Medical Informatics						Using Machine Learning to Improve Geriatric Emergency Care	Accidental falls contribute a large proportion of disease burden in the United States, particularly among older adults. Falls can lead to permanent disability and even death. Current guidelines suggest educational and environmental fall-prevention measure be taken for individuals at high risk of falls. However, these preventative measures are often not taken in primary care settings. High risk individuals are often seen in the emergency department, for falls or other comorbidities, making the emergency department a suitable place for identifying those who would most benefit from fall-prevention interventions. Although screening for fall risk is recommended in emergency departments, resource limitations- including both emergency department and referral limitations- prevent this from occurring. For this reason, there is a need for an efficient, scalable, low-burden screening tool that can successfully identify individuals who would benefit from fall prevention interventions. We have successfully piloted a machine learning based model which provides a real time "risk of falling" score at the time of ED visits, which is used to alert clinicians to patients who are high risk, and an associated workflow to allow clinicians to easily refer patients. We are in the process of both improving the underlying models by adding text-derived elements from notes, and improving the workflow in response to clinician feedback.	0	The students role will be to either a) study the effect of adding additional variables derived from notes on the precision and accuracy of our risk-stratification model or b)help analyze provider behaviors and attitudes towards working with the falls risk reduction pilot using data already collected at interviews	High- i will meet with a student weekly to outline a project, and help overcome any barriers to completion with regards to data access and analysis plans.	Preferred background in programming, specifically python	IRB approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, UW undergraduates interested in research	please see https://scholar.google.com/citations?user=sczIA0cAAAAJ&hl=en for a full list	Yes	Jessie Libber jslibber@medicine.wisc.edu	Using Machine Learning to Improve Geriatric Emergency Care: Accidental falls contribute a large proportion of disease burden in the United States, particularly among older adults. Falls can lead to permanent disability and even death. Current guidelines suggest educational and environmental fall-prevention measure be taken for individuals at high risk of falls. However, these preventative measures are often not taken in primary care settings. High risk individuals are often seen in the emergency department, for falls or other comorbidities, making the emergency department a suitable place for identifying those who would most benefit from fall-prevention interventions. Although screening for fall risk is recommended in emergency departments, resource limitations- including both emergency department and referral limitations- prevent this from occurring. For this reason, there is a need for an efficient, scalable, low-burden screening tool that can successfully identify individuals who would benefit from fall prevention interventions. We have successfully piloted a machine learning based model which provides a real time "risk of falling" score at the time of ED visits, which is used to alert clinicians to patients who are high risk, and an associated workflow to allow clinicians to easily refer patients. We are in the process of both improving the underlying models by adding text-derived elements from notes, and improving the workflow in response to clinician feedback. ____________________________________________________________________________ Role - The students role will be to either a) study the effect of adding additional variables derived from notes on the precision and accuracy of our risk-stratification model or b)help analyze provider behaviors and attitudes towards working with the falls risk reduction pilot using data already collected at interviews; IRB Status - IRB approved; Skills - Preferred background in programming, specifically python	Brian Patterson, bpatter@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudgttMcKp16TiV4vnxXEW0iie7kgJzZ-dxXEYHOnOKpzoyByi6ezU6KaOcLfxlFnMc
15/12/2020	mspulia@medicine.wisc.edu	Michael	Pulia	MD MS	Asst Professor	708	Emergency Medicine								Antimicrobial Stewardship in the Emergency Department	The student will work with Dr. Pulia to select an antibiotic stewardship focused sub-project from a variety of ongoing studies. Currently there are studies ongoing focused on skin and soft tissue infections, urinary tract infections and pneumonia. https://www.emed.wisc.edu/michael-pulia-md-ms	1	The student will be involved with their project planning/organization, data collection, analysis and scientific writing.	Moderate to high independence required	Experience working with electronic databases, including basic statistically analysis programming skills, are required	Approved	Yes	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, UW undergraduates interested in research	1. Paul M, Pulia M, Pulcini C. Antibiotic Stewardship in the Emergency Department: Not to be Overlooked. Clinical Microbiology and Infection. 2020. In Press. 2. Pulia M, Wolf I, Schwei R, Chen D, Lepak A, Schulz L, Safdar N. Antibiotic Prescribing Patterns for COVID-19 in Two Emergency Departments with Rapid Procalcitonin. Infection Control and Hospital Epidemiology. 2020. In Press. 3. Pulia MS, Redwood B. Empiric Antibiotic Prescribing for Suspected Sepsis: A Stewardship Balancing Act. American Journal of the Medical Sciences. 2020. In-press. PMC6482602 4. Valmadrid LC, Schwei RJ, Maginot E, Pulia MS. The Impact of Healthcare Provider Relationships and Communication Dynamics on Urinary Tract Infection Management and Antibiotic Utilization for Long-Term Care Facility Residents Treated in the Emergency Department: A Qualitative Study. American Journal of Infection Control. 2020. Online ahead of print. PMC7348612 5. Pulia MS, Hesse S, Schwei RJ, Schulz LT, Sethi A, Hamedani A. Inappropriate Antibiotic Prescribing for Respiratory Conditions Does Not Improve Press Ganey Patient Satisfaction Scores in the Emergency Department. Open Forum Infectious Diseases. Editor’s Choice. 2020;7(6). PMC In Process	Yes	Rebecca Schwei rschwei@medicine.wisc.edu	Antimicrobial Stewardship in the Emergency Department: The student will work with Dr. Pulia to select an antibiotic stewardship focused sub-project from a variety of ongoing studies. Currently there are studies ongoing focused on skin and soft tissue infections, urinary tract infections and pneumonia. https://www.emed.wisc.edu/michael-pulia-md-ms ____________________________________________________________________________ Role - The student will be involved with their project planning/organization, data collection, analysis and scientific writing. ; IRB Status - Approved; Skills - Experience working with electronic databases, including basic statistically analysis programming skills, are required	Michael Pulia, mspulia@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudMJbScd3s9G1qVLMhPJzweRJ1qgRRqoN_1zKWrkXJZQJpTRdR3inMUR3I5vywR6Es
15/12/2020	huy.dinh@wisc.edu	Huy	Dinh	Ph.D.	Assistant Professor of Oncology		Oncology		Biostatistics and Medical Informatics						Identification of immune cell signatures in cancer using single-cell genomic data	Immunotherapy such as immune checkpoint blockade has revolutionized anti-cancer treatment. However, the majority of patients still do not have clinical benefits with the same treatment. There is an urgent need to dissect immune cell composition in individual patients in order to better understand the immunotherapy response. Single-cell genomic technologies allow us to analyze tumor cellular microenvironments at a single-cell resolution to identify novel immunotherapeutic targets and biomarkers that had not been possible before. In our lab, we are interested in leveraging single-cell and bioinformatics approaches to study immune cell heterogeneity and plasticity in cancer. Currently, we have used single-cell genomic data we generated in-house as well as accessible from publicly available repositories to identify myeloid cell signatures and how they interact with other immune cells such as T and NK cell types that can predict tumor progression and therapy response in different cancer-types. The in silico results will be validated using clinical samples and mouse models in close collaboration with cancer oncologists and biologists at UW Carbone Cancer Center and School of Public Health and Medicine. Website: dinhlab.oncology.wisc.edu	2	- Will work with graduate students and postdocs in active projects in the lab studying colon/GI, multiple myeloma and head and neck cancers. - Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project(s).		Knowledge in cancer/immunology/sequencing/bioinformatics/statistics is a plus but not required	N/A	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Dinh HQ, Lin X, Abbasi, Nameki R, Haro M, Olingy CE, Chang H, Hernandez L, Gayther S, Wright KN, Aspuria PJ, Karlan B, Corona RI, Li A, RImel BJ, Siedhoff M, Medeiros F, Lawrenson K. Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian Tube. (Accepted, preprint link) Dinh HQ, Eggert T, Meyer MA, Zhu YP, Olingy CE, Llewellyn R, Runpei W, Hedrick CC. Coexpression of CD71 and CD117 identifies an early unipotent neutrophil progenitor population in human bone marrow. Immunity 53, 319–334.	Yes	martinson@oncology.wisc.edu	Identification of immune cell signatures in cancer using single-cell genomic data: Immunotherapy such as immune checkpoint blockade has revolutionized anti-cancer treatment. However, the majority of patients still do not have clinical benefits with the same treatment. There is an urgent need to dissect immune cell composition in individual patients in order to better understand the immunotherapy response. Single-cell genomic technologies allow us to analyze tumor cellular microenvironments at a single-cell resolution to identify novel immunotherapeutic targets and biomarkers that had not been possible before. In our lab, we are interested in leveraging single-cell and bioinformatics approaches to study immune cell heterogeneity and plasticity in cancer. Currently, we have used single-cell genomic data we generated in-house as well as accessible from publicly available repositories to identify myeloid cell signatures and how they interact with other immune cells such as T and NK cell types that can predict tumor progression and therapy response in different cancer-types. The in silico results will be validated using clinical samples and mouse models in close collaboration with cancer oncologists and biologists at UW Carbone Cancer Center and School of Public Health and Medicine. Website: dinhlab.oncology.wisc.edu ____________________________________________________________________________ Role - - Will work with graduate students and postdocs in active projects in the lab studying colon/GI, multiple myeloma and head and neck cancers. - Depending on the skills and interests, students will learn how to perform and/or analyze genomic and single-cell data and lead independent project(s). ; IRB Status - N/A; Skills - Knowledge in cancer/immunology/sequencing/bioinformatics/statistics is a plus but not required	Huy Dinh, huy.dinh@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufVcEdV59ceYWrsmO9I02ZBb1He5UaSfVuupT4YKNcsCmMy_qaQnY-IZ-vomjQSdeU
15/12/2020	zuegge@wisc.edu	Karin	Zuegge	MD	Associate Professor	6.082.638.100	Anesthesiology								Carbon Footprint of Healthcare	Background Pollution prevention is the new patient safety movement. Climate change is going to be one of the biggest concerns for public health in the 21st century. (UW population health institute: https://www.countyhealthrankings.org/explore-health-rankings/measures-data-sources/2019-measures) How does health care contribute to climate change? The health care sector is the largest contributor to carbon emissions in the United States after the food service industry. Having a more accurate picture of the carbon footprint of an organization and where the emissions stem from can help identify areas of improvement and potentially drive policy for change. (https://jamanetwork.com/journals/jama/fullarticle/184856) Data gathering The sustainability program has data on waste and energy usage across the organization. Compiling this data into a comprehensive report describing the emissions profile of UW Health as a whole would be the main goal of this project. Another aspect of this project could be to seek data where it does not exist in the form of, e.g. waste audits. Sustainability program website: https://www.uwhealth.org/sustainable-conservation-healthy-environment/green-steps/40629 Literature collection: https://anesthesia.wisc.edu/sustainable-anesthesiology/	0	Scope emissions determination, data gathering and reporting	Variable, can be done remotely with frequent check-in	Enthusiasm for sustainability and basic spreadsheet knowledge	N/A	No	Yes	Yes	Shorter term projects, Research Electives for credit	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	https://pubmed.ncbi.nlm.nih.gov/31094796/ and https://pubs.asahq.org/monitor/issue/84/4	Yes	Mary Roth: maroth4@wisc.edu Mary Evers Statz: mary.statz@uwmf.wisc.edu	Carbon Footprint of Healthcare: Background Pollution prevention is the new patient safety movement. Climate change is going to be one of the biggest concerns for public health in the 21st century. (UW population health institute: https://www.countyhealthrankings.org/explore-health-rankings/measures-data-sources/2019-measures) How does health care contribute to climate change? The health care sector is the largest contributor to carbon emissions in the United States after the food service industry. Having a more accurate picture of the carbon footprint of an organization and where the emissions stem from can help identify areas of improvement and potentially drive policy for change. (https://jamanetwork.com/journals/jama/fullarticle/184856) Data gathering The sustainability program has data on waste and energy usage across the organization. Compiling this data into a comprehensive report describing the emissions profile of UW Health as a whole would be the main goal of this project. Another aspect of this project could be to seek data where it does not exist in the form of, e.g. waste audits. Sustainability program website: https://www.uwhealth.org/sustainable-conservation-healthy-environment/green-steps/40629 Literature collection: https://anesthesia.wisc.edu/sustainable-anesthesiology/ ____________________________________________________________________________ Role - Scope emissions determination, data gathering and reporting; IRB Status - N/A; Skills - Enthusiasm for sustainability and basic spreadsheet knowledge	Karin Zuegge, zuegge@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuenBw3IsUHliXo0Sm2EDpx004u0M6BAwz1-ii_OwWuyLpwSqbAUxRAQYyx3Tz_wez0
11/01/2021	spiker@ortho.wisc.edu	Andrea	Spiker	M.D.	Assistant Professor, Orthopedic Surgery	4.105.753.451	Orthopedics and Rehabilitation	Sports medicine			Alison Brooks, MD	Brooks@ortho.wisc.edu	Orthopedics and Rehabilitation		Vitamin D levels and Musculoskeletal injuries in Collegiate Athletes	We would like to involve a summer research student in a sports medicine study involving data obtained in conjunction with the Badger Athletic Department. This project will provide the student with the opportunity to learn about the basics of developing a research study, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of collegiate athletes to determine the association between pre-participation serum vitamin D levels and subsequent musculoskeletal injuries during sports participation. We will collect data on labs, injuries reported, as well as athlete sport, position, demographics, game data, injury history as well as performance outcome measures, all collected as current standard of practice. In addition to working on this specific project, the student will also contribute to entering data into the UW Hip Preservation Registry, which is a prospective registry of all patients who present with non-arthritic hip pain. This will give the student experience with registries and the significant role of registries in research. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine) to have a more complete understanding of the importance of this study.	0	A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the Hip Preservation Registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects.	Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience.	Excel and Word. Organizational skills and good communication with the other members of the team.	IRB application in process.	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Parks RB, Hetzel SJ, Brooks MA. Iron Deficiency and Anemia among Collegiate Athletes: A Retrospective Chart Review. Med Sci Sports Exerc. 2017 Aug;49(8):1711-1715 Parks RB, Helwig D, Dettmann J, Taggart T, Woodruff B, Horsfall K, Brooks MA. Developing a Performance Nutrition Curriculum for Collegiate Athletics. J Nutr Educ Behav. 2016 Jun;48(6):419-424.e1.	Yes	Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator	Vitamin D levels and Musculoskeletal injuries in Collegiate Athletes: We would like to involve a summer research student in a sports medicine study involving data obtained in conjunction with the Badger Athletic Department. This project will provide the student with the opportunity to learn about the basics of developing a research study, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of collegiate athletes to determine the association between pre-participation serum vitamin D levels and subsequent musculoskeletal injuries during sports participation. We will collect data on labs, injuries reported, as well as athlete sport, position, demographics, game data, injury history as well as performance outcome measures, all collected as current standard of practice. In addition to working on this specific project, the student will also contribute to entering data into the UW Hip Preservation Registry, which is a prospective registry of all patients who present with non-arthritic hip pain. This will give the student experience with registries and the significant role of registries in research. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the Hip Preservation Registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - IRB application in process.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team.	Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Alison Brooks, MD Brooks@ortho.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf5Z6q-qNxSJXYgNB0EhblXQRFB1iTizWT_eGTv2DLdbnMoUIxz23Tl_aaOwtpVUWs
17/12/2020	schneiderd@surgery.wisc.edu	David	Schneider	MD, MS	Assistant Professor	608	Surgery	Surgery	Biostatistics and Medical Informatics	Physician Informatics					Studying Telehealth Use and Access in Wisconsin	We have a number of Clinical Informatics Projects looking at Telehealth access, usage, and quality. This includes in detail studies by Department/Specialty, Diagnosis, as well as looking at failure rates and quality of the visits.	1	The student will conduct an independent research project with guidance from Dr. Schneider, his research fellow, and other study team members. Additionally, the student will interact with regulatory and Enterprise Analytics staff to obtain data and ensure its quality.	semi-independent	Excel - spreadsheets and database, basic statistics, hard-working	N/A - depends on specific project	No	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	We have a telehealth paper being submitted right now	Yes	n/a	Studying Telehealth Use and Access in Wisconsin: We have a number of Clinical Informatics Projects looking at Telehealth access, usage, and quality. This includes in detail studies by Department/Specialty, Diagnosis, as well as looking at failure rates and quality of the visits. ____________________________________________________________________________ Role - The student will conduct an independent research project with guidance from Dr. Schneider, his research fellow, and other study team members. Additionally, the student will interact with regulatory and Enterprise Analytics staff to obtain data and ensure its quality. ; IRB Status - N/A - depends on specific project; Skills - Excel - spreadsheets and database, basic statistics, hard-working	David Schneider, schneiderd@surgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud_XBb2p_vi8YdSjfmDHlztM9YcIc64sgCZqdz96VN4lbxt54OadFkwZ5NL_Mgh7Cw
17/12/2020	amcmillan@uwhealth.org	Alan	McMillan	PhD	Associate Professor		Radiology	Imaging Sciences	Medical Physics						Applications of Deep Learning in Medical Imaging	Students can participate in one of three projects depending on interest and experience. There is a high likelihood of a publication opportunities as a result of participating in these research projects: 1. Development of whole body segmentation and quantification techniques for PET/CT and PET/MR imaging. This project needs students to help segment different anatomical regions/organs on CT and MR images and would be a good introductory project for students interested in deep learning AI and medical imaging. Students do not need prior experience in programming or deep learning. 2. Utilize publicly available datasets to create demonstration datasets, pre-trained deep learning segmentation models, and documentation for a lab-built deep learning segmentation software program for different imaging modalities and body regions and disease processes. Students do not prior experience in programming or deep learning. 3. Assist in managing an ongoing project to study the use of deep learning to create synthetic CT images for use in PET/MR and radiotherapy planning. This includes management of a database in Flywheel, quality review of processed images, performing or assisting in the analysis of deep learning images, and performing statistical assessments of output data. Previous analysis experience in Matlab and/or Python is required. 4. Assist with managing an ongoing project to study the effect of automated head motion correction in PET imaging. This includes management of a database in Flywheel, quality review of processed images, communication of study progress to collaborating physicians, and assistance in statistical assessments of imaging data. Previous analysis experience in Matlab or Python will be helpful.	0	Students will assist in variety of tasks applying artificial intelligence to medical imaging. Please see above for possible opportunities based on previous research experience and technical abilities.	Medium	See above	Approved	Yes	Yes	Yes	Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	https://scholar.google.com/citations?hl=en&user=6vTQ2qMAAAAJ&view_op=list_works&sortby=pubdate	Yes	N/A	Applications of Deep Learning in Medical Imaging: Students can participate in one of three projects depending on interest and experience. There is a high likelihood of a publication opportunities as a result of participating in these research projects: 1. Development of whole body segmentation and quantification techniques for PET/CT and PET/MR imaging. This project needs students to help segment different anatomical regions/organs on CT and MR images and would be a good introductory project for students interested in deep learning AI and medical imaging. Students do not need prior experience in programming or deep learning. 2. Utilize publicly available datasets to create demonstration datasets, pre-trained deep learning segmentation models, and documentation for a lab-built deep learning segmentation software program for different imaging modalities and body regions and disease processes. Students do not prior experience in programming or deep learning. 3. Assist in managing an ongoing project to study the use of deep learning to create synthetic CT images for use in PET/MR and radiotherapy planning. This includes management of a database in Flywheel, quality review of processed images, performing or assisting in the analysis of deep learning images, and performing statistical assessments of output data. Previous analysis experience in Matlab and/or Python is required. 4. Assist with managing an ongoing project to study the effect of automated head motion correction in PET imaging. This includes management of a database in Flywheel, quality review of processed images, communication of study progress to collaborating physicians, and assistance in statistical assessments of imaging data. Previous analysis experience in Matlab or Python will be helpful. ____________________________________________________________________________ Role - Students will assist in variety of tasks applying artificial intelligence to medical imaging. Please see above for possible opportunities based on previous research experience and technical abilities.; IRB Status - Approved; Skills - See above	Alan McMillan, amcmillan@uwhealth.org -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudOKQ1NoJulD2BLb0S3UbCs1iGo9G5UOaf08XidhOUtLaljiw3zEG_4Eq48L6a5iW8
18/12/2020	kmiller5@uwmf.wisc.edu	Katie	Miller	MD	Assistant Professor	2.062.761.272	Medicine	General Internal Medicine							Patient and Clinical Outcomes from an Osteoarthritis Management Program	Osteoarthritis is a common disease that is can be difficult to treat. To address these barriers, new models of care are being proposed and implemented. UW Health as implemented an osteoarthritis management program. The effectiveness of these programs compared to usual care is not known. https://www.uwhealth.org/orthopedic-surgery-rehab/knee-and-hip-comprehensive-non-surgical-osteoarthritis-management-clinic/51216	0	Student will help with chart review of patient reported outcomes as well as evaluation of patient satisfaction and quality of care data from an established osteoarthritis program. Student may also have the opportunity to conduct patient interviews.	Student will need to have home access to health link and be able to work fairly independently but with good support and frequent check ins.	Use of Excel	approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	DPT students, MPH students, PhD students	a. Miller K, Galusha B, Baier L, Micek M. Management of knee and hip osteoarthritis in primary care. J Gen Intern Med. 2018;33(suppl 1):s251. b. Miller KA, Baier Manwell LM, Rabago D. Multimodal Care for Knee and Hip Osteoarthritis: A Pilot Feasibility Study of a Novel Approach to a Common Problem. WMJ. 2020 Mar; 119(1):44-47. c. Eyles JP, Hunter DJ, Bennell KL, Dziedzic KS, Hinman RS, van der Esch M, Holden MA, Bowden JL, Joint Effort Initiative Members & Collaborators (…, Miller K, et al). Priorities for the effective implementation of osteoarthritis management programs: An OARSI international consensus exercise. Osteoarthritis Cartilage. 2019 Sep; 27(9):1270-9 d. Miller K, Baier Manwell L, Osman F. Patient and Provider Perceptions of Knee and Hip Osteoarthritis Care: A Qualitative Study. Int Clin Pract. 2020; 74:e13627.	No	Linda Baier; Sheri Reinders	Patient and Clinical Outcomes from an Osteoarthritis Management Program: Osteoarthritis is a common disease that is can be difficult to treat. To address these barriers, new models of care are being proposed and implemented. UW Health as implemented an osteoarthritis management program. The effectiveness of these programs compared to usual care is not known. https://www.uwhealth.org/orthopedic-surgery-rehab/knee-and-hip-comprehensive-non-surgical-osteoarthritis-management-clinic/51216 ____________________________________________________________________________ Role - Student will help with chart review of patient reported outcomes as well as evaluation of patient satisfaction and quality of care data from an established osteoarthritis program. Student may also have the opportunity to conduct patient interviews. ; IRB Status - approved; Skills - Use of Excel	Katie Miller , kmiller5@uwmf.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuduOsmS9nHM4UaF25A2VzJ1WQHgEHJzgK_VJhXX9TOLzq35nWIfzhd9ZZ-J6dr57tA
18/12/2020	vprabhakaran@uwhealth.org	Vivek	Prabhakaran	MD, PhD	Associate Professor of Radiology	6.082.655.269	Radiology	Neuroradiology	Medical Physics						Stroke CT ASPECTS scoring	The project involves evaluating an AI software that automatically calculates ASPECTS score on stroke CTs and how well it performs compared to neuroradiology experts. This will entail retrospectively looking at 100s of stroke CTs and tabulating the ASPECTS score calculated by the AI software as well as the experts' rating and comparing the two scores with the ground truth which can be obtained from the perfusion CT images. https://radiology.wisc.edu/research/research-labs-and-groups/neuroimaging-research-program/	0	The student will use PACS to view the stroke CT images and the neuroradiology report and collect the information needed for the project. Then they will do statistical analyses to evaluate AI software performance vs. expert performance compared to the ground truth perfusion images.		minimal statistical analyses - excel file use	already have IRB protocol approved	Yes	Yes	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Clinical fmri project	PhD students	machine learning manuscripts from our lab. https://scholar.google.com/citations?user=nTd0-lAAAAAJ	Yes	N/A	Stroke CT ASPECTS scoring: The project involves evaluating an AI software that automatically calculates ASPECTS score on stroke CTs and how well it performs compared to neuroradiology experts. This will entail retrospectively looking at 100s of stroke CTs and tabulating the ASPECTS score calculated by the AI software as well as the experts' rating and comparing the two scores with the ground truth which can be obtained from the perfusion CT images. https://radiology.wisc.edu/research/research-labs-and-groups/neuroimaging-research-program/ ____________________________________________________________________________ Role - The student will use PACS to view the stroke CT images and the neuroradiology report and collect the information needed for the project. Then they will do statistical analyses to evaluate AI software performance vs. expert performance compared to the ground truth perfusion images.; IRB Status - already have IRB protocol approved; Skills - minimal statistical analyses - excel file use	Vivek Prabhakaran, vprabhakaran@uwhealth.org -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuexa_e9umaNmLR9bzjeAiFuDyTrgMQloQFhyxHefpLNC5e1ngD3ptO9wTtp14rxPOU
18/12/2020	jfloberg@humonc.wisc.edu	John	Floberg	MD, PhD	Assistant Professor (CHS)	262	Human Oncology								Prognostic significance of imaging characteristics and radiation dose and fractionation in the treatment of prostate cancer	BACKGROUND: In the last several years there has been a dramatic increase in the use of advanced imaging modalities, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI), in the initial evaluation and staging of prostate cancer. These imaging modalities allow us to identify areas of cancer with far more accuracy, both within the prostate as well as in the rest of the body, and they therefore have the potential to dramatically change how we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative and semi-quantitative metrics can be derived from these images. Determining if these imaging metrics are prognostic of outcomes for patients with prostate cancer may help guide treatment decisions and contribute to personalized therapy (e.g. use of radiation therapy, radiation dose, use of androgen deprivation therapy, duration of androgen deprivation therapy). One way advanced imaging modalities may impact radiation therapy is in selection of radiation dose and fractionation. A number of studies have investigated the effects of total radiation dose and dose per fraction on outcomes and toxicities in prostate cancer. The overall conclusions from these studies can essentially be summarized as: 1) Increased radiation dose improves disease control, at the cost of worse toxicity, and 2) When only the prostate is treated, higher radiation doses per fraction (hypofractionation) can be used while maintaining disease outcomes and without worsening toxicities. For the last several years, a number of patients have been treated at the University of Wisconsin trying to escalate dose to specific areas of the target volume (for example lesions seen on MRI) while maintaining strict constraints on surrounding organs. Studying disease outcomes and toxicities associated with such an approach would help identify clinical questions that should be further studied prospectively. SPECIFIC AIMS: 1. Identify pre-treatment imaging characteristics from positron emission tomography (PET), computed tomography (CT), and magnetic resonance imagine (MRI) that are prognostic for outcomes for patients with prostate cancer treated with radiation therapy. 2. Determine if radiation dose and fractionation (e.g. hypofractionation, dose escalation) impact disease outcomes (e.g. biochemical disease free survival, distant-metastasis free survival, overall survival) in patients with prostate cancer treated with radiation therapy. 2. Determine if radiation dose and fractionation and/or imaging characteristics are associated with acute and late toxicities in patients with prostate cancer treated with radiation therapy. PROCEDURES: This study is a retrospective review of information pertaining to the diagnosis, treatment, toxicity, and outcomes of patients diagnosed with prostate cancer and treated with radiation therapy from 1/1/2007- 10/31/2019. Individual patient records will be reviewed to identify various patient, treatment, disease, and toxicity outcomes. We will use the hospital's medical record system to obtain patient clinical and treatment characteristics, overall survival, disease free survival, distant metastasis free survival, and cancer specific survival. We will also assess the toxicities associated with treatment. Records to be reviewed include consult notes, progress notes, procedure notes, imaging studies, and pathology reports. In addition to review of medical records, we will also review clinical images (e.g. PET/CT and MRI scans) obtained as part of routine clinical care. These images will be analyzed in our departmental software used for routine clinical care (MIM). De-identified images will also be analyzed using commercially available software (e.g. Matlab) to perform analysis that cannot be carried out in MIM. Descriptive statistics, parametric tests (e.g. Student’s t-test), and non-parametric tests (e.g. Fisher’s exact, Mann-Whitney U test) will be used to compare different groups of patients. Survival analysis will be performed using standard methods (Kaplan-meier, log-rank, Cox regression) to evaluate the prognostic significance of different radiation dose/fractionation schemes, and imaging based markers. Cumulative incidence, logistic regression, and other regression analyses will be used to evaluate time to toxicities and hazard ratios for toxicities for patients treated with different dose/fractionation schemes, and for patients grouped by different imaging characteristics.	1	Review patient charts. Curate and contribute to a clinical database. Analyze clinical images (e.g. PET and MRI). Perform statistical analyses	The student should show initiative in asking specific questions within the context of the project outlined above. They should plan to independently analyze clinical or imaging data with regular check-ins and guidance (e.g. once weekly meetings)	Background with image analysis and/or coding would be helpful, but is not required	Approved. Minimal risk.	No	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	PhD students, UW undergraduates interested in research	Calai et al, Potential impact of 68Ga-PSMA-11 PET/CT on prostate cancer definitive radiation therapy planning. J Nucl Med. 2018. Calais et al, Comparison of 68Ga-PSMA-11 and 18F-Fluciclovine PET/CT in a case series of 10 patients with prostate cancer recurrence. J Nucl Med. 2018. Schreibmann et al, Image guided planning for prostate carcinomas with incorporation of anti-3-[18F]FACBC (fluciclovine) positron emission tomography: workflow and initial findings from a randomized trial. IJROBP, 2016. Lee et al, Randomized phase III non inferiority study comparing two radiotherapy fractionation schedules in patients with low-risk prostate cancer. JCO, 2016 Dearnaley et al, Conventional versus hypo fractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomized, non-inferiority, phase 3 CHHiP trial. Lancet Oncol, 2016	No	Ranee Williams-Toycen, williams@humonc.wisc.edu	Prognostic significance of imaging characteristics and radiation dose and fractionation in the treatment of prostate cancer: BACKGROUND: In the last several years there has been a dramatic increase in the use of advanced imaging modalities, particularly positron emission tomography (PET) and magnetic resonance imaging (MRI), in the initial evaluation and staging of prostate cancer. These imaging modalities allow us to identify areas of cancer with far more accuracy, both within the prostate as well as in the rest of the body, and they therefore have the potential to dramatically change how we approach treatment. In addition to identifying areas of prostate cancer, both PET and MRI can provide functional and physiologic information about a cancer, and a number of quantitative and semi-quantitative metrics can be derived from these images. Determining if these imaging metrics are prognostic of outcomes for patients with prostate cancer may help guide treatment decisions and contribute to personalized therapy (e.g. use of radiation therapy, radiation dose, use of androgen deprivation therapy, duration of androgen deprivation therapy). One way advanced imaging modalities may impact radiation therapy is in selection of radiation dose and fractionation. A number of studies have investigated the effects of total radiation dose and dose per fraction on outcomes and toxicities in prostate cancer. The overall conclusions from these studies can essentially be summarized as: 1) Increased radiation dose improves disease control, at the cost of worse toxicity, and 2) When only the prostate is treated, higher radiation doses per fraction (hypofractionation) can be used while maintaining disease outcomes and without worsening toxicities. For the last several years, a number of patients have been treated at the University of Wisconsin trying to escalate dose to specific areas of the target volume (for example lesions seen on MRI) while maintaining strict constraints on surrounding organs. Studying disease outcomes and toxicities associated with such an approach would help identify clinical questions that should be further studied prospectively. SPECIFIC AIMS: 1. Identify pre-treatment imaging characteristics from positron emission tomography (PET), computed tomography (CT), and magnetic resonance imagine (MRI) that are prognostic for outcomes for patients with prostate cancer treated with radiation therapy. 2. Determine if radiation dose and fractionation (e.g. hypofractionation, dose escalation) impact disease outcomes (e.g. biochemical disease free survival, distant-metastasis free survival, overall survival) in patients with prostate cancer treated with radiation therapy. 2. Determine if radiation dose and fractionation and/or imaging characteristics are associated with acute and late toxicities in patients with prostate cancer treated with radiation therapy. PROCEDURES: This study is a retrospective review of information pertaining to the diagnosis, treatment, toxicity, and outcomes of patients diagnosed with prostate cancer and treated with radiation therapy from 1/1/2007- 10/31/2019. Individual patient records will be reviewed to identify various patient, treatment, disease, and toxicity outcomes. We will use the hospital's medical record system to obtain patient clinical and treatment characteristics, overall survival, disease free survival, distant metastasis free survival, and cancer specific survival. We will also assess the toxicities associated with treatment. Records to be reviewed include consult notes, progress notes, procedure notes, imaging studies, and pathology reports. In addition to review of medical records, we will also review clinical images (e.g. PET/CT and MRI scans) obtained as part of routine clinical care. These images will be analyzed in our departmental software used for routine clinical care (MIM). De-identified images will also be analyzed using commercially available software (e.g. Matlab) to perform analysis that cannot be carried out in MIM. Descriptive statistics, parametric tests (e.g. Student’s t-test), and non-parametric tests (e.g. Fisher’s exact, Mann-Whitney U test) will be used to compare different groups of patients. Survival analysis will be performed using standard methods (Kaplan-meier, log-rank, Cox regression) to evaluate the prognostic significance of different radiation dose/fractionation schemes, and imaging based markers. Cumulative incidence, logistic regression, and other regression analyses will be used to evaluate time to toxicities and hazard ratios for toxicities for patients treated with different dose/fractionation schemes, and for patients grouped by different imaging characteristics. ____________________________________________________________________________ Role - Review patient charts. Curate and contribute to a clinical database. Analyze clinical images (e.g. PET and MRI). Perform statistical analyses; IRB Status - Approved. Minimal risk.; Skills - Background with image analysis and/or coding would be helpful, but is not required	John Floberg, jfloberg@humonc.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudyHRkoBHz3zt50c4i39hk4L-e-oj5hQQAYWWVmVaEd9bN8iWA3bECrntl6CFIj7yI
19/12/2020	ngarg@medicine.wisc.edu	Neetika	Garg	MD	Assistant Professor		Medicine	Nephrology							Oxalate nephropathy in kidney transplantation recipients	There is very limited literature on risk factors and relevance of oxalate nephropathy in kidney transplantation. Using a set of transplant recipients with oxalate nephropathy and controls, the goal of this project would be to 1) identify risk factors for oxalate nephropathy and 2) impact of this diagnosis on patient and allograft outcomes.	0	Data collection, analysis, writing	Medium. Should have healthlink access.	NA	Expect to be covered under the umbrella IRB our division has i.e. no additional IRB work required.	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	PMID: 31810202	No	NA	Oxalate nephropathy in kidney transplantation recipients: There is very limited literature on risk factors and relevance of oxalate nephropathy in kidney transplantation. Using a set of transplant recipients with oxalate nephropathy and controls, the goal of this project would be to 1) identify risk factors for oxalate nephropathy and 2) impact of this diagnosis on patient and allograft outcomes. ____________________________________________________________________________ Role - Data collection, analysis, writing; IRB Status - Expect to be covered under the umbrella IRB our division has i.e. no additional IRB work required.; Skills - NA	Neetika Garg, ngarg@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuevE0MTL_5rdsdVXIKZGIKx5EY1VFTSO_bzX21GkcYugLQeucRBgndRGaUPMHDOIIc
20/12/2020	rwoods@uwhealth.org	Ryan	Woods	MD, MPH	Assistant Professor of Radiology	6.082.639.377	Radiology	Breast Imaging and Intervention							BI-RADS 4A Calcifications: Radiologist Accuracy in Determining Risk for Breast Cancer	Calcifications are commonly present on digital mammography and can be associated with both benign and malignant processes. Evaluation of suspicious calcifications is completed with spot compression views during diagnostic mammography evaluation. Specific descriptors are utilized to assess calcifications which then subsequently guide management. Based on current BIRADS classification guidelines, suspicious calcifications may be classified as 4B (moderate suspicion) or 4C (high suspicion). However, there is question as to whether or not calcifications can be appropriately subcategorized as BIRADS 4A (low suspicion) based on specific imaging characteristics. This study is designed to assess the postive predictive value for calcifications that are determined to be of low suspicion during diagnostic mammogram examination.	0	Data collection, data analysis, and manuscript preparation	Moderate	None specific	Approved under Radiology Retrospective Study IRB	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	Not currently available to mentor other students	Please see https://paperpile.com/shared/42JkfI	No	Lorene Seman	BI-RADS 4A Calcifications: Radiologist Accuracy in Determining Risk for Breast Cancer: Calcifications are commonly present on digital mammography and can be associated with both benign and malignant processes. Evaluation of suspicious calcifications is completed with spot compression views during diagnostic mammography evaluation. Specific descriptors are utilized to assess calcifications which then subsequently guide management. Based on current BIRADS classification guidelines, suspicious calcifications may be classified as 4B (moderate suspicion) or 4C (high suspicion). However, there is question as to whether or not calcifications can be appropriately subcategorized as BIRADS 4A (low suspicion) based on specific imaging characteristics. This study is designed to assess the postive predictive value for calcifications that are determined to be of low suspicion during diagnostic mammogram examination. ____________________________________________________________________________ Role - Data collection, data analysis, and manuscript preparation; IRB Status - Approved under Radiology Retrospective Study IRB; Skills - None specific	Ryan Woods, rwoods@uwhealth.org -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud8QVK4Y4YnBw0quexcgvTmOm_dOQImjqe7mmH_dtQ1P1CzIK-svW2DrlKc2OIxsgE
22/12/2020	mlubner@uwhealth.org	Meghan	Lubner	MD	Professor	6.082.639.028	Radiology	Abdominal Imaging and Intervention			Perry Pickhardt	ppickhardt2@uwhealth.org	Radiology	Abdominal Imaging and Intervention	Multiple abdominal radiology projects	1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones, liver, spleen. Possible renal stone volume project now. 2. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series 3. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques (DLIR), ex impact of use of oral contrast in ED, oral contrast and visceral fat (using AI tool), consequences of changing kV and impact on HU measurements. Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, stercoral colitis series, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc 4. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 6. CT colonography related projects 7. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 8. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc	0	Project lead	Moderate	Basic excel, word, ppt, knowledge of R a bonus	approved	No	Radiology R/D has helped cover in past	Yes	Research Electives for credit	Not currently available to mentor other students	Sampling of prior Shapiro publications: Bannas, P., Bakke, J., Patrick, J. L., & Pickhardt, P. J. (2015). Automated volumetric analysis for comparison of oral sulfate solution (SUPREP) with established cathartic agents at CT colonography (vol 40, pg 11, 2015). Abdominal Imaging, 40(6), 2066-2066. doi:10.1007/s00261-015-0415-y Elissa, M., Lubner, M. G., & Pickhardt, P. J. (2019). Biopsy of Deep Pelvic and Abdominal Targets With Ultrasound Guidance: Efficacy of Compression. AJR Am J Roentgenol, 1-6. doi:10.2214/AJR.19.21104 Hunt, O. M. F., Lubner, M. G., Ziemlewicz, T. J., del Rio, A. M., & Pickhardt, P. J. (2016). The Liver Segmental Volume Ratio for Noninvasive Detection of Cirrhosis: Comparison With Established Linear and Volumetric Measures. Journal of Computer Assisted Tomography, 40(3), 478-484. doi:10.1097/Rct.0000000000000389 Kim, N. Y., Lubner, M. G., Nystrom, J. T., Swietlik, J. F., Abel, E. J., Havighurst, T. C., . . . Pickhardt, P. J. (2019). Utility of CT Texture Analysis in Differentiating Low-Attenuation Renal Cell Carcinoma From Cysts: A Bi-Institutional Retrospective Study. AJR Am J Roentgenol, 213(6), 1259-1266. doi:10.2214/AJR.19.21182 Lee, S. J., Binkley, N., Lubner, M. G., Bruce, R. J., Ziemlewicz, T. J., & Pickhardt, P. J. (2016). Opportunistic screening for osteoporosis using the sagittal reconstruction from routine abdominal CT for combined assessment of vertebral fractures and density. Osteoporos Int, 27(3), 1131-1136. doi:10.1007/s00198-015-3318-4 Lubner, M. G., Malecki, K., Kloke, J., Ganeshan, B., & Pickhardt, P. J. (2017). Texture analysis of the liver at MDCT for assessing hepatic fibrosis. Abdom Radiol (NY), 42(8), 2069-2078. doi:10.1007/s00261-017-1096-5 Lubner, M. G., Stabo, N., Abel, E. J., del Rio, A. M., & Pickhardt, P. J. (2016). CT Textural Analysis of Large Primary Renal Cell Carcinomas: Pretreatment Tumor Heterogeneity Correlates With Histologic Findings and Clinical Outcomes. American Journal of Roentgenology, 207(1), 96-105. doi:10.2214/Ajr.15.15451 Lubner, M. G., Stabo, N., Lubner, S. J., del Rio, A. M., Song, C., Halberg, R. B., & Pickhardt, P. J. (2015). CT textural analysis of hepatic metastatic colorectal cancer: pre-treatment tumor heterogeneity correlates with pathology and clinical outcomes. Abdom Imaging, 40(7), 2331-2337. doi:10.1007/s00261-015-0438-4 Lubner, M. G., Stabo, N., Lubner, S. J., Del Rio, A. M., Song, C., & Pickhardt, P. J. (2017). Volumetric Versus Unidimensional Measures of Metastatic Colorectal Cancer in Assessing Disease Response. Clin Colorectal Cancer, 16(4), 324-333 e321. doi:10.1016/j.clcc.2017.03.009 Patrick, J. L., Bakke, J. R., Bannas, P., Kim, D. H., Lubner, M. G., & Pickhardt, P. J. (2015). Objective volumetric comparison of room air versus carbon dioxide for colonic distention at screening CT colonography. Abdominal Imaging, 40(2), 231-236. doi:10.1007/s00261-014-0206-x Pickhardt, P. J., Bakke, J., Kuo, J., Robbins, J. B., Lubner, M. G., del Rio, A. M., & Kim, D. H. (2014). Volumetric Analysis of Colonic Distention According to Patient Position at CT Colonography: Diagnostic Value of the Right Lateral Decubitus Series. American Journal of Roentgenology, 203(6), W623-W628. doi:10.2214/Ajr.13.12369 Pickhardt, P. J., Malecki, K., Hunt, O. F., Beaumont, C., Kloke, J., Ziemlewicz, T. J., & Lubner, M. G. (2017). Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis. Eur Radiol, 27(7), 3060-3068. doi:10.1007/s00330-016-4648-0 Pickhardt, P. J., Malecki, K., Kloke, J., & Lubner, M. G. (2016). Accuracy of Liver Surface Nodularity Quantification on MDCT as a Noninvasive Biomarker for Staging Hepatic Fibrosis. AJR Am J Roentgenol, 207(6), 1194-1199. doi:10.2214/ajr.16.16514 Scrima, A., Lubner, M. G., King, S., Kennedy, G., & Pickhardt, P. J. (2017). Abdominal Multidetector Computed Tomography for Suspected Small-Bowel Obstruction: Multireader Study Comparing Radiologist Performance for Predicting Surgical Outcomes. Journal of Computer Assisted Tomography, 41(3), 388-393. doi:10.1097/Rct.0000000000000529 Scrima, A., Lubner, M. G., King, S., Pankratz, J., Kennedy, G., & Pickhardt, P. J. (2017). Value of MDCT and Clinical and Laboratory Data for Predicting the Need for Surgical Intervention in Suspected Small-Bowel Obstruction. American Journal of Roentgenology, 208(4), 785-793. doi:10.2214/Ajr.16.16946 Scrima, A. T., Lubner, M. G., Abel, E. J., Havighurst, T. C., Shapiro, D. D., Huang, W., & Pickhardt, P. J. (2019). Texture analysis of small renal cell carcinomas at MDCT for predicting relevant histologic and protein biomarkers. Abdominal Radiology, 44(6), 1999-2008. doi:10.1007/s00261-018-1649-2	No	Lorene Seman	Multiple abdominal radiology projects: 1. CT Volumetrics: Use 3D post processing tools to assess volumes on CT images, past examples include volume measurements of renal or pancreatic cysts, renal stones, liver, spleen. Possible renal stone volume project now. 2. Image guided Biopsy: Assemble data from US and CT guided biopsy data bases, assess diagnostic yield, complications/safety, examples would include lung biopsy for mass vs consolidation (yield, complications), inpt vs outpt biopsy, lung only cohort of clinical trial pts vs controls (more passes, more complications in patients on clinical trials?); complications of biopsy in adenoma or adenoma like lesions. US pancreas bx, transvaginal bx series 3. General CT projects: Projects around oral contrast utilization, CT dose, novel CT techniques such as dual energy CT, CT protocols, deep learning reconstruction techniques (DLIR), ex impact of use of oral contrast in ED, oral contrast and visceral fat (using AI tool), consequences of changing kV and impact on HU measurements. Clinical projects to include topics like perforation and distribution of gas following optical colonoscopy, stercoral colitis series, differentiating chronic cholecystitis vs GB ca, perforated diverticulitis from perforated colon ca etc 4. CT rad path project: Work on direct rad path correlation for CT of ex vivo surgical specimens (this may be a longer term project) 5. CT findings in liver disease including CT texture analysis, volumetrics, liver surface nodularity-past cohorts include HCV, NAFLD, could look at large pooled cohort 6. CT colonography related projects 7. Artificial Intelligence related projects using automated biometric CT measures to opportunistically stratify cardiometabolic risk (large project with side projects) 8. Miscellaneous projects, ex ileal pouch project looking at post procedure imaging appearance and complications; rate of positive esophagrams with pneumomediastinum etc ____________________________________________________________________________ Role - Project lead; IRB Status - approved; Skills - Basic excel, word, ppt, knowledge of R a bonus	Meghan Lubner, mlubner@uwhealth.org -- Co-Mentor: Perry Pickhardt ppickhardt2@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucCvsshdlxqRiC5TLCUHL2tltH62ZZ-ZKYHsBd69EfC8r92qJIruPqul2tC-U6ifkI
23/12/2020	stadler@neurosurgery.wisc.edu	James	Stadler	MD	Assistant Professor of Neurosurgery and Pediatrics	6.082.620.687	Neurological Surgery								Statistical Analysis in Pediatric Neurosurgery	The student will help identify a topic of interest that can be assessed in large datasets (e.g., KID/NIS, NSQIP). With guidance, they will clean and analyze this data with the goal of meaningful insights into the underlying questions. This project will be then targeted to presentation and publication.	0	To start, the student will gain necessary statistical coding skills if needed (do not let this scare you away, we can/will help teach this!) The student will join with a larger group to share and promote progress with the project. This scope and output of this project ultimately is determined by this progress.	Variable depending on student comfort	Basic statistical background. Prior coding skills (particularly Python/R) are useful but not required. The student needs a computer.	N/A	No	No (plan to use Dean's Office Funds)	No	Shorter term projects	DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	“National Trends in Utilization and Inpatient Admission Outcomes for Children Undergoing Intrathecal Pump and Rhizotomy Surgeries: A 1997 – 2016 Kids’ Inpatient Database Analysis.” 49th Annual Meeting of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Pediatric Neurological Surgery. Virtual Meeting. December 2020. “Neurosurgical Utilization and Complications in Children with Achondroplasia: 1997 – 2016 Kids’ Inpatient Database Analysis.” 49th Annual Meeting of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Pediatric Neurological Surgery. Virtual Meeting. December 2020.	No	N/A	Statistical Analysis in Pediatric Neurosurgery: The student will help identify a topic of interest that can be assessed in large datasets (e.g., KID/NIS, NSQIP). With guidance, they will clean and analyze this data with the goal of meaningful insights into the underlying questions. This project will be then targeted to presentation and publication. ____________________________________________________________________________ Role - To start, the student will gain necessary statistical coding skills if needed (do not let this scare you away, we can/will help teach this!) The student will join with a larger group to share and promote progress with the project. This scope and output of this project ultimately is determined by this progress.; IRB Status - N/A; Skills - Basic statistical background. Prior coding skills (particularly Python/R) are useful but not required. The student needs a computer.	James Stadler, stadler@neurosurgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucDNoYce2sVqIvwcjLWw-JSgfHw106zlSkaJ6nj_GMYMkoHJsWsFNX1IPybYQJu7Yc
23/12/2020	stadler@neurosurgery.wisc.edu	James	Stadler	MD	Assistant Professor of Neurosurgery and Pediatrics	6.082.620.687	Neurological Surgery								Virtual Pediatric Spinal Biomechanical Analysis	We have preliminarily developed a virtual biomechanical model of the pediatric spine, to allow for finite element analysis relative to dynamic growth and simulated surgical interventions. To help continue this project, the student will expand the existing models to include pathological states (e.g., trauma, spina bifida, achondroplasia) and a wider range of surgical interventions.	0	The student will work with our existing models and data while also developing complementary models for FEA.	Moderate	An engineering background is strongly encouraged	Approved	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	PhD students, UW undergraduates interested in research	Submitted to American Association of Neurological Surgery 2021 annual meeting, publication also pending.	No	N/A	Virtual Pediatric Spinal Biomechanical Analysis: We have preliminarily developed a virtual biomechanical model of the pediatric spine, to allow for finite element analysis relative to dynamic growth and simulated surgical interventions. To help continue this project, the student will expand the existing models to include pathological states (e.g., trauma, spina bifida, achondroplasia) and a wider range of surgical interventions. ____________________________________________________________________________ Role - The student will work with our existing models and data while also developing complementary models for FEA.; IRB Status - Approved; Skills - An engineering background is strongly encouraged	James Stadler, stadler@neurosurgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc9t3f5_m-g9oDv_f4vhKdOvzuzyj1pqb07wNND0lrj6RQzTBhewVp4_TJk3Te51wM
26/12/2020	lsalkowski@uwhealth.org	Lonie	Salkowski	MD PhD	Professor	265	Radiology	Breast Imaging & Intervention	Medical Physics						Improving our understanding of Breast Tissue Density Assessment on Mammography	Screening mammography is used to detect breast cancer prior to it becoming clinically evident. One part of the screening mammography is the assessment of breast tissue density. There is evidence that increased breast tissue density plays a role in increased risk of breast cancer. There are limited tools universally available for assessing breast tissue density on the mammogram, thus the majority of breast tissue density is assessed by the radiologist. There are numerous reports about the inconsistency of breast tissue density with both inter- and intra- observer variability. Limited research has been performed to determine the underlying cause of this variability. This project would like to investigate a possible source of this variability and also determine if a simple AI tool can be trained to assess breast tissue density more predictably.	0	The role of the student will be helping set up a reader study containing mammograms to be assessed for breast tissue density, and implement them with participants (residents, fellows, faculty). The student will help collect and analyze the study data. The student will also help train an AI tool with the same data set and compare this data to the participants.	Students will have independent time with performing tasks and also mentored time.	Good communication skills, computer skills, ability to work in excel and some statistical work	In process	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Slanetz PJ, Daye D, Chen P, Salkowski L (all co-authors). Artificial Intelligence and Machine Learning in Radiology Education – is it ready for prime time? JACR published online may 16, 2020. 1Richardson ML, Agarwal A, Adams S, Auffermann WF, Bhattacharya AK, Consul N, Fotos JS, Ikuta I, Kelahan LC, Lin C, Lo HS, Nguyen XV, Salkowski LR, Sin JM, Thomas RC, Wassef S. Review of Artificial Intelligence Training Tools and Courses for Radiologists. Whitepaper for Academic Radiology. Salkowski L, Elezaby M, Fowler A, Burnside B, Woods, Strigel B. Comparison of screening mammography technical recalls from FFDM and digital breast tomosynthesis (DBT). Journal of Medical Imaging (2018).	No	Margaret Birrenkott MBirrenkott@uwhealth.org and Lorene Seman lseman@uwhealth.org	Improving our understanding of Breast Tissue Density Assessment on Mammography: Screening mammography is used to detect breast cancer prior to it becoming clinically evident. One part of the screening mammography is the assessment of breast tissue density. There is evidence that increased breast tissue density plays a role in increased risk of breast cancer. There are limited tools universally available for assessing breast tissue density on the mammogram, thus the majority of breast tissue density is assessed by the radiologist. There are numerous reports about the inconsistency of breast tissue density with both inter- and intra- observer variability. Limited research has been performed to determine the underlying cause of this variability. This project would like to investigate a possible source of this variability and also determine if a simple AI tool can be trained to assess breast tissue density more predictably. ____________________________________________________________________________ Role - The role of the student will be helping set up a reader study containing mammograms to be assessed for breast tissue density, and implement them with participants (residents, fellows, faculty). The student will help collect and analyze the study data. The student will also help train an AI tool with the same data set and compare this data to the participants. ; IRB Status - In process; Skills - Good communication skills, computer skills, ability to work in excel and some statistical work	Lonie Salkowski, lsalkowski@uwhealth.org -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue3W9z53sFAO3OmKSDP0Yd6DeiaEMjrZ-WTLCjhtCJhBeBbP-RTCLp5Wea6UeSEM_Y
27/12/2020	agrayev@uwhealth.org	Allison	Grayev	MD	Associate Professor	6.082.627.854	Radiology	Neuroradiology			Anthony Kuner MD	akuner@uwhealth.org	Radiology	Neuroradiology	Impact of Procedural Lumbar Puncture Service on Fluoroscopically Guided Lumbar Punctures	We aim to determine the factors prompting referral to radiology-services for fluoroscopic-guidance for lumbar puncture with respect to the overall procedure volume at UW Health. We will analyze the data prior to and following the creation of a hospitalist-based procedural service, which will theoretically decrease referrals for imaging-guided procedures, decreasing average procedure cost of lumbar puncture, radiation exposure, and utilization of a service needed by other patients requiring imaging-guided procedures.	0	EPIC record search, literature review, manuscript writing	Ability to utilize EMR	Excel, EMR	IRB exemption already acquired as QI project	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	Not currently available to mentor other students	Menger, R. P., Wa, P., Hefner, M., Nanda, A., & Cuellar, H. (2017). Economic Outcomes of the Addition of Fluoroscopic Guidance to the Lumbar Puncture Procedure: A Call for Standardized Training. Journal of Spine, 06(01). doi: 10.4172/2165-7939.1000359 Hudgins, P., Fountain, A., Chapman, P., & Shah, L. (2017). Difficult Lumbar Puncture: Pitfalls and Tips from the Trenches. American Journal of Neuroradiology, 38(7), 1276–1283. doi: 10.3174/ajnr.a5128	Yes	n/a	Impact of Procedural Lumbar Puncture Service on Fluoroscopically Guided Lumbar Punctures: We aim to determine the factors prompting referral to radiology-services for fluoroscopic-guidance for lumbar puncture with respect to the overall procedure volume at UW Health. We will analyze the data prior to and following the creation of a hospitalist-based procedural service, which will theoretically decrease referrals for imaging-guided procedures, decreasing average procedure cost of lumbar puncture, radiation exposure, and utilization of a service needed by other patients requiring imaging-guided procedures. ____________________________________________________________________________ Role - EPIC record search, literature review, manuscript writing; IRB Status - IRB exemption already acquired as QI project; Skills - Excel, EMR	Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner MD akuner@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue7mf7rckoVdKEi_Yw3JIkCw55abFHSjx4wwmmxkxfsGJXvyk_DrEleeT-yLSGoL8Y
29/12/2020	nickel@ortho.wisc.edu	Brian	Nickel	MD	Assistant Professor	608	Orthopedics and Rehabilitation	Adult Reconstruction							Biomechanics of Total Hip Replacement Acetabular Component Fixation Improvement with Screw Placement	This project will evaluate fixation and construct design of acetabular components in total hip arthroplasty with the goal of quantifying a minimum threshold and potentially an intra-operative test that will validate this being met. We will investigate the pullout strength of several constructs with the following cohorts: 1) gold standard 1mm press fit 2) gold standard with 1 and 2 screws 3) no press fit with 1/2/3 screws of varying purchase quality.	0	Student will have a unique opportunity to learn about total hip replacement in the biomechanics lab, operating room, and clinic. This project will primarily involve time in the biomechanics lab working with 3D printed pelvis modes, then placing acetabular components and testing the pullout strength of several constructs with the following cohorts: 1) gold standard 1mm press fit 2) gold standard with 1 and 2 screws 3) no pressfit with 1/2/3 screws of varying purchase quality. Secondarily, as described above, the student will have ample time scrubbed in the operating room observing and understanding the significance of this concept. Lastly, the student will shadow in clinic where they will interact with patients and review radiographic appearance of acetabular components/screw position and how it influences clinical outcomes.	Varies, lab work will be with PhD team, OR/clinic with Dr Nickel, but literature review and abstract/manuscript generation more independence	none	n/a	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	https://pubmed.ncbi.nlm.nih.gov/26733644/ https://pubmed.ncbi.nlm.nih.gov/26733644/ https://pubmed.ncbi.nlm.nih.gov/18701253/	Yes	n/a	Biomechanics of Total Hip Replacement Acetabular Component Fixation Improvement with Screw Placement: This project will evaluate fixation and construct design of acetabular components in total hip arthroplasty with the goal of quantifying a minimum threshold and potentially an intra-operative test that will validate this being met. We will investigate the pullout strength of several constructs with the following cohorts: 1) gold standard 1mm press fit 2) gold standard with 1 and 2 screws 3) no press fit with 1/2/3 screws of varying purchase quality. ____________________________________________________________________________ Role - Student will have a unique opportunity to learn about total hip replacement in the biomechanics lab, operating room, and clinic. This project will primarily involve time in the biomechanics lab working with 3D printed pelvis modes, then placing acetabular components and testing the pullout strength of several constructs with the following cohorts: 1) gold standard 1mm press fit 2) gold standard with 1 and 2 screws 3) no pressfit with 1/2/3 screws of varying purchase quality. Secondarily, as described above, the student will have ample time scrubbed in the operating room observing and understanding the significance of this concept. Lastly, the student will shadow in clinic where they will interact with patients and review radiographic appearance of acetabular components/screw position and how it influences clinical outcomes.; IRB Status - n/a; Skills - none	Brian Nickel, nickel@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufT5Bs87JjDnsdc7r3Mv_iNbr3l1is-kdk3z9cf6QfBWIAs6cQMwrzotideE9VoTpk
30/12/2020	grimes@urology.wisc.edu	Matthew	Grimes	MD	Assistant Professor		Urology								Alterations in Collagen Structure in Lichen Sclerosus	Lichen sclerosus is a poorly understood inflammatory condition of the genital skin which is associated with severe urethral strictures in affected men. Reconstructive surgery is the only hope for definitive cure, however fails in more than 50% of cases. The etiology of this disease is unknown which precludes therapeutic advances – specifically development of minimally invasive alternatives to morbid surgery. This project is part of a larger NIH funded proposal to probe a specific molecular pathway in the pathogenesis of fibrosis in lichen sclerosus. This summer project would focus on characterization of collagen structure in human lichen sclerosus tissues using both standard histochemical methods and microscopy as well as second harmonic generation microscopy in collaboration with Dr. Campagnola in the Biomedical Engineering Department at UW-Madison. Specific responsibilities include performing staining and microscopic analysis of previously obtained tissue and limited collection of relevant clinical data from the medical record. Students will have the opportunity to submit and present the findings at regional and national meetings as well as submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests.	0	Perform staining, microscopy, and analysis of human tissues. Construction of a clinical database including limited collection of clinical data from the medical record. Will work closely with the mentor to perform data analysis and reporting of the results through meeting presentation and manuscript submission.		Experience with immunohistochemical methods preferred but not required	Approved	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	PMID: 31091176	Yes	n/a	Alterations in Collagen Structure in Lichen Sclerosus: Lichen sclerosus is a poorly understood inflammatory condition of the genital skin which is associated with severe urethral strictures in affected men. Reconstructive surgery is the only hope for definitive cure, however fails in more than 50% of cases. The etiology of this disease is unknown which precludes therapeutic advances – specifically development of minimally invasive alternatives to morbid surgery. This project is part of a larger NIH funded proposal to probe a specific molecular pathway in the pathogenesis of fibrosis in lichen sclerosus. This summer project would focus on characterization of collagen structure in human lichen sclerosus tissues using both standard histochemical methods and microscopy as well as second harmonic generation microscopy in collaboration with Dr. Campagnola in the Biomedical Engineering Department at UW-Madison. Specific responsibilities include performing staining and microscopic analysis of previously obtained tissue and limited collection of relevant clinical data from the medical record. Students will have the opportunity to submit and present the findings at regional and national meetings as well as submit manuscripts for publication. In addition, students will have the opportunity to shadow in urology clinic and the operating room in accordance with their interests. ____________________________________________________________________________ Role - Perform staining, microscopy, and analysis of human tissues. Construction of a clinical database including limited collection of clinical data from the medical record. Will work closely with the mentor to perform data analysis and reporting of the results through meeting presentation and manuscript submission. ; IRB Status - Approved; Skills - Experience with immunohistochemical methods preferred but not required	Matthew Grimes, grimes@urology.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudbkdWRhE8k_ma98gd8JcJ4gW898DNDGLbxPPobq_gaGkIyArbmInBoyivRDZcEg-Q
11/01/2021	spiker@ortho.wisc.edu	Andrea	Spiker	M.D.	Assistant Professor, Orthopedic Surgery	6.082.346.716	Orthopedics and Rehabilitation	Sports Medicine			Connie Chamberlain	chamberlain@ortho.wisc.edu	Orthopedics and Rehabilitation	Bioinspired Materials Lab	How do cellular and molecular inflammatory markers coincide with patient presentation in hip impingement and hip dysplasia?	We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry with a portion of the student’s time spent in the lab learning basic lab techniques associated with translational research. This project will provide the student with the opportunity to learn about the basics of developing a registry, performing basic bench research assays, collaborating with statisticians, clinicians, PhD scientists, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves the prospective collection of tissue from hips of patients undergoing hip arthroscopy for femoroacetabular impingement and hip dysplasia and analysis of molecular and cellular factors present at the time of surgery which could be indicative of inflammatory pathways and/or early osteoarthritis. Additionally, we will be correlating these cellular markers with patient demographics, presentation, symptomatology, radiographic measurements and clinical examination findings as well as patient reported outcome scores. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (FAI and dysplasia) to have a more complete understanding of the importance of this study.	0	A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the hip preservation registry. Specific tasks related to the project detailed above include spending 1-2 days/week in the WIMR lab with co-PI Dr. Connie Chamberlain, PhD, learning the basics of bench research, and the remainder of the time will be spent maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will collaborate with other Shapiro students to be involved in and co-author additional projects, so they can expect to have multiple projects on his/her CV by the end of the summer. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical and translational research and how to complete research projects.	Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience.	Excel and Word. Organizational skills and good communication with the other members of the team. Lab experience will be a direct mentorship model with co-PI Dr. Connie Chamberlain and may include RNA isolation, cDNA synthesis, PCR and flow cytometry.	IRB approved.	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	This would be a stand-alone project, so no related publications exist. The idea would be for the student to complete and be a published author on this project.	Yes	Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator	How do cellular and molecular inflammatory markers coincide with patient presentation in hip impingement and hip dysplasia? : We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry with a portion of the student’s time spent in the lab learning basic lab techniques associated with translational research. This project will provide the student with the opportunity to learn about the basics of developing a registry, performing basic bench research assays, collaborating with statisticians, clinicians, PhD scientists, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves the prospective collection of tissue from hips of patients undergoing hip arthroscopy for femoroacetabular impingement and hip dysplasia and analysis of molecular and cellular factors present at the time of surgery which could be indicative of inflammatory pathways and/or early osteoarthritis. Additionally, we will be correlating these cellular markers with patient demographics, presentation, symptomatology, radiographic measurements and clinical examination findings as well as patient reported outcome scores. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the two patient groups we are studying (FAI and dysplasia) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the hip preservation registry. Specific tasks related to the project detailed above include spending 1-2 days/week in the WIMR lab with co-PI Dr. Connie Chamberlain, PhD, learning the basics of bench research, and the remainder of the time will be spent maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeons, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will collaborate with other Shapiro students to be involved in and co-author additional projects, so they can expect to have multiple projects on his/her CV by the end of the summer. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical and translational research and how to complete research projects. ; IRB Status - IRB approved.; Skills - Excel and Word. Organizational skills and good communication with the other members of the team. Lab experience will be a direct mentorship model with co-PI Dr. Connie Chamberlain and may include RNA isolation, cDNA synthesis, PCR and flow cytometry.	Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor: Connie Chamberlain chamberlain@ortho.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudkh-Jd8hptP3HTwP7p8ug1oMNRfHikvtN5QaX_ypXbHBN18gL1OzmZxVlU1QKe5cY
31/12/2020	majid.afshar@wisc.edu	Majid	Afshar	MD, MS	Assistant Professor	312	Medicine	Pulmonary and Critical Care							Development of Natural Language Generation and Natural Langauge Inference Task from the Electronic Health Record	The trainee will work in the data science lab of Drs. Majid Afshar and Matthew Churpek. This project is to advance the science in clinical natural language processing by working in an annotation software to build a supervised task for deep learning algorithms to predict diagnoses and treatment plans in the clinical notes. Electronic health records will be reviewed and tagged by the trainee, and the results will serve as inputs into a machine learning model. The trainee will learn clinical informatics, data science, and coding in both Python and R languages. He or she will work with a team of physician-scientists, computer scientists, and biostatisticians. The final product will be to publish a new NLP task for the data science community and host a data challenge through University of Wisconsin. The winning model from the data challenge will serve as a model for prognostication in health outcomes, which are research aims in our lab's grants from the National Institute of Health and Department of Defense.	0	Annotator and data wrangler	Yes	Background in IT or coding preferred	Approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	https://pubmed.ncbi.nlm.nih.gov/33259943/, https://pubmed.ncbi.nlm.nih.gov/32590389/, https://pubmed.ncbi.nlm.nih.gov/33131794/, https://pubmed.ncbi.nlm.nih.gov/32349766/, https://pubmed.ncbi.nlm.nih.gov/31233140/, https://pubmed.ncbi.nlm.nih.gov/31310611/, https://pubmed.ncbi.nlm.nih.gov/30602031/, https://pubmed.ncbi.nlm.nih.gov/31145455/	Yes	Lab Manager - Madeline Oguss (mkoguss@medicine.wisc.edu), Lab Co-Lead - Matthew Churpek (mchurpek@medicine.wisc.edu)	Development of Natural Language Generation and Natural Langauge Inference Task from the Electronic Health Record: The trainee will work in the data science lab of Drs. Majid Afshar and Matthew Churpek. This project is to advance the science in clinical natural language processing by working in an annotation software to build a supervised task for deep learning algorithms to predict diagnoses and treatment plans in the clinical notes. Electronic health records will be reviewed and tagged by the trainee, and the results will serve as inputs into a machine learning model. The trainee will learn clinical informatics, data science, and coding in both Python and R languages. He or she will work with a team of physician-scientists, computer scientists, and biostatisticians. The final product will be to publish a new NLP task for the data science community and host a data challenge through University of Wisconsin. The winning model from the data challenge will serve as a model for prognostication in health outcomes, which are research aims in our lab's grants from the National Institute of Health and Department of Defense. ____________________________________________________________________________ Role - Annotator and data wrangler; IRB Status - Approved; Skills - Background in IT or coding preferred	Majid Afshar, majid.afshar@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueC3OU-4nb8uI51HofnMC8ixP4q5nJ5TemKOupm5BrpjgXU-O_LZq_LGyFBMO1MPfc
31/12/2020	mchurpek@medicine.wisc.edu	Matthew	Churpek	MD, MPH, PhD	Associate Professor of Medicine	3.302.093.895	Medicine	Pulmonary and Critical Care	Biostatistics and Medical Informatics						Using machine learning to predict critical illness syndromes	Clinical deterioration in hospitalized patients is a common, deadly, and often predictable event. Early detection of critical illness is key to achieving timely intensive care and decreasing the rate of preventable cardiac arrests. Our lab has previously developed a machine learning tool to identify high-risk patients (eCART) using variables from the electronic health record data. Although this score helps to bring critical care resources to the bedside, one important yet unanswered question is what clinical teams should do once they get to the bedside. Determining the most common critical illness syndromes in critically ill patients and then creating decision support tools to suggest potential life-saving therapies is vital to decrease preventable death.	0	The student's primary role will be to perform chart reviews on patients with clinical deterioration to determine the cause of deterioration and potential life-saving treatments. These data will be collected and then merged with electronic health record data, which the student will then use to perform statistical analysis. These analyses will range from descriptive statistics to machine learning models, depending on their interests and expertise.	The student will perform independent chart reviews after initial training by the PI and staff. The student will be supported by our data science lab, which is led by Drs. Churpek and Afshar and includes a program manager, three staff data scientists, and two post-docs.	No specific skills are required, although experience with statistical programs such as Stata or R would be helpful. Students will learn how to perform statistical analyses with their data regardless of their experience level.	Approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	MPH students, PhD students	Our lab's publications, many of which are related to this work, can be found here: https://pubmed.ncbi.nlm.nih.gov/?term=churpek+m Specific examples include: https://pubmed.ncbi.nlm.nih.gov/32796184/ https://pubmed.ncbi.nlm.nih.gov/32780123/ https://pubmed.ncbi.nlm.nih.gov/26771782/	No	Madeline Oguss (mkoguss@medicine.wisc.edu)	Using machine learning to predict critical illness syndromes: Clinical deterioration in hospitalized patients is a common, deadly, and often predictable event. Early detection of critical illness is key to achieving timely intensive care and decreasing the rate of preventable cardiac arrests. Our lab has previously developed a machine learning tool to identify high-risk patients (eCART) using variables from the electronic health record data. Although this score helps to bring critical care resources to the bedside, one important yet unanswered question is what clinical teams should do once they get to the bedside. Determining the most common critical illness syndromes in critically ill patients and then creating decision support tools to suggest potential life-saving therapies is vital to decrease preventable death. ____________________________________________________________________________ Role - The student's primary role will be to perform chart reviews on patients with clinical deterioration to determine the cause of deterioration and potential life-saving treatments. These data will be collected and then merged with electronic health record data, which the student will then use to perform statistical analysis. These analyses will range from descriptive statistics to machine learning models, depending on their interests and expertise. ; IRB Status - Approved; Skills - No specific skills are required, although experience with statistical programs such as Stata or R would be helpful. Students will learn how to perform statistical analyses with their data regardless of their experience level.	Matthew Churpek, mchurpek@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud66ZbRiKSYOQdJyRCYFhBtK_Mg-JLrP2QWjTr7IsiAHrb0rm-wUq24PDRL5gojCdk
31/12/2020	agrayev@uwhealth.org	Allison	Grayev	MD	Associate Professor		Radiology	Neuroradiology			Anthony Kuner, M.D.	akuner@uwhealth.org	Radiology	Neuroradiology	Lumbar Puncture (LP) CSF Flow Dynamics	The project will consist of analysis of fluid dynamics in the setting of lumbar punctures, and an assessment of different devices used for lumbar puncture and evaluation of the affects on procedure time and flow rates.	0	The student will use different devices that are used clinically for lumbar puncture in a model experimental setup to evaluate the flow differences and potential impact on procedure time.	Mostly independent project, can be conducted on or off campus	Microsoft Office (Word, Excel, Powerpoint)	N/A	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	Not currently available to mentor other students	1. Sahin SH, Colak A, Arar C, Yıldırım I, Sut N, Turan A. Modified 45-degree head-up tilt increases success rate of lumbar puncture in patients undergoing spinal anesthesia. J Anesth. 2014 Aug;28(4):544-8. doi: 10.1007/s00540-013-1764-8. Epub 2014 Jan 4. PMID: 24389883. 2. Carson D, Serpell M. Choosing the best needle for diagnostic lumbar puncture. Neurology. 1996 Jul;47(1):33-7. doi: 10.1212/wnl.47.1.33. PMID: 8710120. 3. Nath S, Koziarz A, Badhiwala JH, Alhazzani W, Jaeschke R, Sharma S, Banfield L, Shoamanesh A, Singh S, Nassiri F, Oczkowski W, Belley-Côté E, Truant R, Reddy K, Meade MO, Farrokhyar F, Bala MM, Alshamsi F, Krag M, Etxeandia-Ikobaltzeta I, Kunz R, Nishida O, Matouk C, Selim M, Rhodes A, Hawryluk G, Almenawer SA. Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis. Lancet. 2018 Mar 24;391(10126):1197-1204. doi: 10.1016/S0140-6736(17)32451-0. Epub 2017 Dec 7. PMID: 29223694.	Yes	N/A	Lumbar Puncture (LP) CSF Flow Dynamics: The project will consist of analysis of fluid dynamics in the setting of lumbar punctures, and an assessment of different devices used for lumbar puncture and evaluation of the affects on procedure time and flow rates. ____________________________________________________________________________ Role - The student will use different devices that are used clinically for lumbar puncture in a model experimental setup to evaluate the flow differences and potential impact on procedure time.; IRB Status - N/A; Skills - Microsoft Office (Word, Excel, Powerpoint)	Allison Grayev, agrayev@uwhealth.org -- Co-Mentor: Anthony Kuner, M.D. akuner@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufFR85f-Z1JhDIXpFl4P9u7naXX2e0UQ84Hbkq4FgB9ZWId1YCkzunLCvBeW_oAwCo
31/12/2020	nahmad@dermatology.wisc.edu	Nihal	Ahmad	PhD	Professor	608	Dermatology								Novel immune-related genes in melanoma	Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. The high rate of metastasis and recurrence among melanoma patients indicate the existence of heterogeneous cell populations within melanoma that have the ability to both initiate metastatic programs and bypass immune recognition. Over the past decade, development of immunotherapy, including checkpoint inhibitors, have transformed the prognosis for many cancer patients. Despite all these advancements, no combined immune biomarkers are formally validated and recommended as a clinical tool for melanoma prognosis. Bioinformatics analyses based on publicly available databases have been utilized to investigate the prognostic markers in various cancers, with which predictive models can be established to assess individual patient survival. Using this approach by analyzing Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, we have identified a panel of nine novel immune-related genes that are differentially expressed in metastatic melanoma and are significantly associated with patient survival. Interestingly, 6 genes are reported to express on immune cells and 3 genes are reported to be involve in proliferation of other cancer types, however the functional significance of these genes is not reported in melanoma. In this project, we will validate clinical relevance of a panel of nine novel immune-related genes predictive of melanoma metastasis and patient survival. Utilizing tissue microarray (TMA) consisting of tissue cores of normal skin, nevi, localized and metastatic melanomas with the state-of-the-art multispectral VectraTM Imaging platform coupled with inFormR software analysis (capable of quantitatively analyzing up to 14 proteins simultaneously in the same tissue), we will determine correlation of these genes with clinical information. Next, employing multiple malignant and metastatic melanoma cell lines, we will determine the expression profile as well as effect of overexpression/knockdown of three selected genes on melanoma cell proliferation and growth. Lab website: https://dermatology.wisc.edu/research/laboratory-research/ahmad-lab/	1	Student will work with other laboratory personnel, on the above project and study the role of novel immune-related genes in melanoma. Depending on the skills and interests, student will learn how to perform and/or analyze tissue microarray data, correlation analyses of genes with clinical parameters. Depending upon progress, there is a possibility of a co-authorship on a future publication.		Basic knowledge in cancer/immunology/bioinformatics/statistics is a plus but not required	N/A	Yes	Department of Dermatology will provide 50% support	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students, Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	PhD students	Laboratory has published a number of melanoma-related papers.	Yes	Ms. Mary Poellinger (mpoellinger@dermatology.wisc.edu)	Novel immune-related genes in melanoma: Melanoma is one of the deadliest forms of skin cancer that can metastasize to become lethal if not diagnosed early. The high rate of metastasis and recurrence among melanoma patients indicate the existence of heterogeneous cell populations within melanoma that have the ability to both initiate metastatic programs and bypass immune recognition. Over the past decade, development of immunotherapy, including checkpoint inhibitors, have transformed the prognosis for many cancer patients. Despite all these advancements, no combined immune biomarkers are formally validated and recommended as a clinical tool for melanoma prognosis. Bioinformatics analyses based on publicly available databases have been utilized to investigate the prognostic markers in various cancers, with which predictive models can be established to assess individual patient survival. Using this approach by analyzing Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, we have identified a panel of nine novel immune-related genes that are differentially expressed in metastatic melanoma and are significantly associated with patient survival. Interestingly, 6 genes are reported to express on immune cells and 3 genes are reported to be involve in proliferation of other cancer types, however the functional significance of these genes is not reported in melanoma. In this project, we will validate clinical relevance of a panel of nine novel immune-related genes predictive of melanoma metastasis and patient survival. Utilizing tissue microarray (TMA) consisting of tissue cores of normal skin, nevi, localized and metastatic melanomas with the state-of-the-art multispectral VectraTM Imaging platform coupled with inFormR software analysis (capable of quantitatively analyzing up to 14 proteins simultaneously in the same tissue), we will determine correlation of these genes with clinical information. Next, employing multiple malignant and metastatic melanoma cell lines, we will determine the expression profile as well as effect of overexpression/knockdown of three selected genes on melanoma cell proliferation and growth. Lab website: https://dermatology.wisc.edu/research/laboratory-research/ahmad-lab/ ____________________________________________________________________________ Role - Student will work with other laboratory personnel, on the above project and study the role of novel immune-related genes in melanoma. Depending on the skills and interests, student will learn how to perform and/or analyze tissue microarray data, correlation analyses of genes with clinical parameters. Depending upon progress, there is a possibility of a co-authorship on a future publication.; IRB Status - N/A; Skills - Basic knowledge in cancer/immunology/bioinformatics/statistics is a plus but not required	Nihal Ahmad, nahmad@dermatology.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueO_hiIoSTGAzk7e0G4epXwEYlaYt6WVQgGvrRvvi0WPKa73_FthTT-VbSTRCdLmKE
01/01/2021	vsetaluri@dermatology.wisc.edu	Vijay	Setaluri	PhD	Professor	6.082.635.362	Dermatology				David Beebe		Pathology and Laboratory Medicine		Understanding the role of skin microenvironment in melanoma tumor development and progression	The goal of the project is to investigate how skin microenvironment modulates oncogene-driven metabolic adaptation of cutaneous melanocytes during melanoma tumor development.	0	The student will participate in an ongoing project to develop melanoma-on-chip and will be involved in human skin primary cell culture, lentivirus-mediated transformation and optical metabolic imaging studies. The student will be a part of a team consisting a graduate student, a postdoctoral researcher and a research specialist.	Not applicable	None	IRB approved	Yes	Departmental	Yes	Shorter term projects, Research Electives for credit	PhD students, UW undergraduates interested in research	1. Ayuso, J., Sadangi, S., Lares, M., Shujah, R., Humayun, M., Denecke., K., Skala, M., Beebe, D., Setaluri, V. (2020) A microfluidic device with air-walls to study the effect of skin microenvironment on primary melanoma cells. Lab on a Chip In revision 2. Ayuso, J. M., Rehman, S., Farooqui, M., Virumbrales-Muñoz, M., Setaluri, V., Skala, M. C., Beebe, D. J. (2020) Microfluidic tumor-on-a-chip model to the study tumor metabolic vulnerability. International Journal of Molecular Sciences 21: 9075 PMID: 33260673 3. Prabhakar, K., Rodriguez, C. I., Jayanthy, A. S., Perera, R. J., Setaluri, V. (2019) Role of miR-214 in regulation of β-catenin and the oncogenic phenotype of melanoma. Molecular Carcinogenesis 58: 1974-1984. 4. Anu Prathap, M. U., Castro-Pérez, E., Jiménez-Torres, J. A., Setaluri, V. and Gunasekaran, S. (2019) A flow-through microfluidic system for the detection of circulating melanoma cells. Biosensors and Bioelectronics 2019 Oct 1;142:111522. doi: 10.1016/j.bios.2019.111522. Epub 2019 Jul 17 (co-corresponding author) 5. Castro-Pérez, E., Rodriguez, C. I., Mikheil, D., Newton, M. A., Siddique, A., McCarthy, A., and Setaluri, V. (2019) Melanoma Tumor Progression Inhibits Pluripotency and Melanoma-Derived iPSC Differentiate Predominantly to Neural-like Cells. Stem Cell Reports 13:177-192 6. Mikheil, D., Prabhakar, K., Arshad, A., Rodriguez, C. I., Newton, M. A., and Setaluri, V. (2019) Melanoma Cells Resistant to MAPKi Acquire Vulnerability to Notch Signaling Activation Pigment Cell & Melanoma Research 32:528-534 7. Seenivasan, R., Warrick, J., Rodriguez, C. I., Beebe, D. J., Setaluri, V., and Gunasekaran, S. (2018) Integrating electrochemical immunosensing and cell adhesion technologies for cancer cell detection and enumeration. Electrochemica Acta 286: 205-211 8. Anu Prathap, M. U., Rodrıguez, C. I., Sadak, O., Guan, J., Setaluri, V., and Gunasekaran, S. (2018) Ultrasensitive electrochemical immunoassay for melanoma cells using mesoporous polyaniline. Chemical Communications 54:710-714 9. Rodríguez, C. I., Castro-Pérez, E., Prabhakar, K., Block, L., Longley, B. J., Wisinski, J. A., Kimple, M.E., Setaluri, V. (2017) EPAC-RAP1 axis-mediated switch in the response of primary and metastatic melanoma to cyclic AMP. Molecular Cancer Research 15:1792-1802 10. Seenivasan, R., Maddodi, N., Setaluri, V., Gunasekaran, S. (2015) An electrochemical immunosensing method for detecting melanoma cells. Biosensors and Bioelectronics 68C:508-515. (*corresponding authors)	Yes	Mary Poellinger (Admin.), Shreyans Sadangi, Dr. Jose Maria Ayuso, Sarah Altameemi	Understanding the role of skin microenvironment in melanoma tumor development and progression: The goal of the project is to investigate how skin microenvironment modulates oncogene-driven metabolic adaptation of cutaneous melanocytes during melanoma tumor development. ____________________________________________________________________________ Role - The student will participate in an ongoing project to develop melanoma-on-chip and will be involved in human skin primary cell culture, lentivirus-mediated transformation and optical metabolic imaging studies. The student will be a part of a team consisting a graduate student, a postdoctoral researcher and a research specialist.; IRB Status - IRB approved; Skills - None	Vijay Setaluri, vsetaluri@dermatology.wisc.edu -- Co-Mentor: David Beebe	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudrE_WJiUpUccmsgrPyfstsh31SOY314Ol4ZBmAetTCpf4hpRZFTJzT1jDt6wCbDAA
03/01/2021	tkennedy@uwhealth.org	Tabby	Kennedy	MD	Associate Professor, Division Chief Neuroradiology	608	Radiology	Neuroradiology			JP Yu	JPYu@uwhealth.org	Radiology	Neuroradiology	Creating a Top Gun Approach to Radiology Education - Stroke Imaging	The goal of the project is to create an imaging data base of patients presenting with acute stroke in order to create a training set to teach residents, fellows and faculty how to interpret stroke code CT examinations.	0	Review health link and the imaging archive to create a data base of patients presenting to UW with stroke over the past 5 years.	Moderate degree of independence with frequent feedback and touch points with faculty mentors	Excel	Will be able to add students to a retrospective IRB	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Manuscript in preparation - “Current Challenges and Future Directions of Radiology Education”	Yes	Katie Yang	Creating a Top Gun Approach to Radiology Education - Stroke Imaging: The goal of the project is to create an imaging data base of patients presenting with acute stroke in order to create a training set to teach residents, fellows and faculty how to interpret stroke code CT examinations. ____________________________________________________________________________ Role - Review health link and the imaging archive to create a data base of patients presenting to UW with stroke over the past 5 years. ; IRB Status - Will be able to add students to a retrospective IRB; Skills - Excel	Tabby Kennedy, tkennedy@uwhealth.org -- Co-Mentor: JP Yu JPYu@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudU3lU_9XFYzRhLPEKI6HajZ8Z9qZy6VkhFCVjr76KsYOM215CbheCpixuT9tpOmN4
04/01/2021	bshields@dermatology.wisc.edu	Bridget	Shields	MD	Assistant Professor	3.199.365.964	Dermatology								Rubella Driving Granulomas: A Natural History Study	There are increasing reports of rubella virus associated with granulomatous inflammation – this has been best characterized among children with immunodeficiencies, but we have identified the presence of rubella within apparently immunologically normal adults. Based upon this, we (dermatologists and the CDC) would like to study this on a larger scale across the United States. This is a CDC funded project that includes a retrospective review to study the prevalence, potential risk factors, and the histopathology of patients with atypical granulomatous disease in more detail. This retrospective review will include searching pathology databases and clinical tools (I2B2 or TrinetX) to gather the total number of granulomatous dermatitis cases and identify atypical granulomatous cases. This will be a multicenter collaboration. Ultimately, these samples will be sent to the CDC for rubella virus identification.	0	Redcap design, retrospective review, discussion of clinical and histopathologic features with dermatologists, dermatopathologists, pathologists and other clinical sites to determine what makes them "atypical". Redcap completion and opportunity for spinoff and follow up retrospective and prospective studies.	Average	Quick learner, reliable, willing to learn RedCap, willing to meet regularly and reliably	Drafted and will be submitted this week by clinical research coordinator	Centers for Disease Control (CDC)	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	An enigma wrapped in a mystery: immunodeficiency granulomas and what lies beneath (Shields, et al.), Oral granulomatous disease (Alawi, Shields, et al.), Diagnosis, clinical features, and management of patients with granulomatous cheilitis (Durgin & Shields), Vulvar Crohn disease: diagnostic challenges and approach to management (Shields, et al.)	Yes	Jennifer Hanser (jhanser@dermatology.wisc.edu), Mary Poellinger (mpoellinger@dermatology.wisc.edu), Nandita Nanchal (mpoellinger@dermatology.wisc.edu)	Rubella Driving Granulomas: A Natural History Study: There are increasing reports of rubella virus associated with granulomatous inflammation – this has been best characterized among children with immunodeficiencies, but we have identified the presence of rubella within apparently immunologically normal adults. Based upon this, we (dermatologists and the CDC) would like to study this on a larger scale across the United States. This is a CDC funded project that includes a retrospective review to study the prevalence, potential risk factors, and the histopathology of patients with atypical granulomatous disease in more detail. This retrospective review will include searching pathology databases and clinical tools (I2B2 or TrinetX) to gather the total number of granulomatous dermatitis cases and identify atypical granulomatous cases. This will be a multicenter collaboration. Ultimately, these samples will be sent to the CDC for rubella virus identification. ____________________________________________________________________________ Role - Redcap design, retrospective review, discussion of clinical and histopathologic features with dermatologists, dermatopathologists, pathologists and other clinical sites to determine what makes them "atypical". Redcap completion and opportunity for spinoff and follow up retrospective and prospective studies. ; IRB Status - Drafted and will be submitted this week by clinical research coordinator; Skills - Quick learner, reliable, willing to learn RedCap, willing to meet regularly and reliably	Bridget Shields, bshields@dermatology.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc673fBs7YOgQG8_oyoOfVltwM-CpAiwdAI9J_AKBfcl9gjYrFfDjwIXNuZSbXS1hk
04/01/2021	rjspencer2@wisc.edu	Ryan	Spencer	MD, MS	Assistant Professor	631	Obstetrics & Gynecology	Gynecologic Oncology							Analysis of endometrial cancer recurrence patterns in the era of telemedicine	Given the shifting landscape of telemedicine, the aim of this project is to analyze the manner in which endometrial cancer recurrences are detected and describe the utility of in-person visits for surveillance in this population. We will look at endometrial cancer patients seen at the UWCCC over the last 10 years to identify the recurrence rate within the population and how the recurrences were identified. The results may have critical implications for the use of telemedicine for cancer surveillance in this population.	2	The students will help with protocol development and writing, data extraction, data analysis, and manuscript writing.		Use of REDCap would be helpful but not required	Submission pending at this time. Patient population already identified from a prior QI project within the division.	No	Yes	Yes	Shorter term projects, Research Electives for credit	Not currently available to mentor other students	1) A quality improvement pathway to rapidly increase telemedicine services in a Gynecologic Oncology clinic during the COVID-19 pandemic with patient satisfaction scores and environmental impact. Gynecol Oncol Rep - in press 2) A population-based study of causes of death after endometrial cancer according to major risk factors. Gynecol Oncol – in press. 3) Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients. PLoS One 2019; 14(10):e0223791. PMID 31618279.	Yes	N/A	Analysis of endometrial cancer recurrence patterns in the era of telemedicine: Given the shifting landscape of telemedicine, the aim of this project is to analyze the manner in which endometrial cancer recurrences are detected and describe the utility of in-person visits for surveillance in this population. We will look at endometrial cancer patients seen at the UWCCC over the last 10 years to identify the recurrence rate within the population and how the recurrences were identified. The results may have critical implications for the use of telemedicine for cancer surveillance in this population. ____________________________________________________________________________ Role - The students will help with protocol development and writing, data extraction, data analysis, and manuscript writing.; IRB Status - Submission pending at this time. Patient population already identified from a prior QI project within the division.; Skills - Use of REDCap would be helpful but not required	Ryan Spencer, rjspencer2@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuca7IF9FpbBxfolKiAbRmnW1oh5614HmT57sfLRrgCkn7ECS3_7W181u1OGXsYt3Rk
04/01/2021	pmfarrell@wisc.edu	Philip	Farrell	Md, PhD (Biochemistry, Hon. D.Sc.(Genetics)	Emeritus Dean and Professor of Pediatrics and Population Health Sciences	608	Pediatrics	Pulmonology and Sleep Medicine	Population Health Sciences		Professor Michael Rock	mjrock@pediatrics.wisc.edu	Pediatrics	Pulmonology and Sleep Medicine	Impact of Genetic Modifiers on Clinical Outcomes in Young Children with Cystic Fibrosis	The hypothesis of this project is that early life manifestations of cystic fibrosis (CF) lung disease and gastrointestinal (GI) phenotypes are influenced by non-CFTR genetic variants. There are two goals: 1) to determine the frequencies of genetic modifiers (non-CFTR genetic variants) that can influence the course of CF in a well characterized cohort of 120 children with CF who have had whole genome sequencing performed to generate unique data as part of a NIH-funded project known as FIRST; and 2) to evaluate the associations of the genetic modifiers identified from goal #1 to pulmonary and GI outcome measures and determine if they explain some of the variations in the onset and severity of CF lung disease GI phenotypes during the first 3 years of life. [https://www.pediatrics.wisc.edu/research/research-groups/farrell/]	0	Organizing and analyzing clinical outcome measures and whole genome sequencing data from the cohort of 120 pediatric CF patients with respect to CF genetic modifiers and their relationship to pulmonary and gastrointestinal phenotypes in the first 3 years of life	Student will have independent access to the results already obtained and will be advised on how to organize a database and then proceed with statistical analyses, followed by an abstract, and ultimately a journal publication	A knowledge of genetics and genomics	Approved annually since 1/26/2018 by HSIRB	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Wilk MA, Braun AT, Farrell, Laxova A, Brown DM, Holt JM, Birch CL, Sosonkina N, Wilk BM, Worthey EA. Applying whole genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis. Cold Spring Harb Mol Case Stud. 2020 Feb 3;6(1). pii: a004531. doi: 10.1101/mcs.a004531. Munck A, Bourmaud A, Bellon G, Picq P, Farrell PM; DPAM Study Group. Phenotype of children with inconclusive cystic fibrosis diagnosis after newborn screening. Pediatr Pulmonol. 2020 Apr;55(4):918-928. doi: 10.1002/ppul.24634. [Epub ahead of print] PMID: 31916691. Farrell PM, Rock MJ, and Baker MW. The impact of the CFTR gene discovery on cystic fibrosis diagnosis, counseling, and preventive therapy. Genes 2020, 11, 401; doi:10.3390/genes11040401	Yes	Dr. Michael Rock [mjrock@pediatrics.wisc.edu]	Impact of Genetic Modifiers on Clinical Outcomes in Young Children with Cystic Fibrosis: The hypothesis of this project is that early life manifestations of cystic fibrosis (CF) lung disease and gastrointestinal (GI) phenotypes are influenced by non-CFTR genetic variants. There are two goals: 1) to determine the frequencies of genetic modifiers (non-CFTR genetic variants) that can influence the course of CF in a well characterized cohort of 120 children with CF who have had whole genome sequencing performed to generate unique data as part of a NIH-funded project known as FIRST; and 2) to evaluate the associations of the genetic modifiers identified from goal #1 to pulmonary and GI outcome measures and determine if they explain some of the variations in the onset and severity of CF lung disease GI phenotypes during the first 3 years of life. [https://www.pediatrics.wisc.edu/research/research-groups/farrell/] ____________________________________________________________________________ Role - Organizing and analyzing clinical outcome measures and whole genome sequencing data from the cohort of 120 pediatric CF patients with respect to CF genetic modifiers and their relationship to pulmonary and gastrointestinal phenotypes in the first 3 years of life; IRB Status - Approved annually since 1/26/2018 by HSIRB; Skills - A knowledge of genetics and genomics	Philip Farrell, pmfarrell@wisc.edu -- Co-Mentor: Professor Michael Rock mjrock@pediatrics.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc-y52sWZGrUKiMr79p6t1wTNcoYXjv1IJk7Q_uDN7NE-yG341NRmX6LlxaJCrR9B4
04/01/2021	jungs@surgery.wisc.edu	Sarah	Jung	PhD	Assistant Professor	608	Surgery								Entrustable Professional Activities in Surgery: Utilizing Microassessments and Feedback	The student will work with the research mentor as well as residents and surgeons in the Department of Surgery to continue facilitate the collection of EPA microassessments using a smartphone-based app. However, just over 3000 microassessments have already been collected from faculty and residents and will be used for both quantitative and qualitative analysis of trends in residents' progression through surgery training.	1	Data organization, cleaning, and analysis. Abstract writing. Presentation of results. Manuscript preparation.		Use of spreadsheets for data cleaning and organization	Approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Stahl, C. C., Collins, E., Jung, S., Rosser, A. A., Kraut, A. S., Schnapp, B. H., ... & Greenberg, J. A. (2020). Implementation of Entrustable Professional Activities into a General Surgery Residency. Journal of Surgical Education. Rosser, A.A., & Jung, S. (2019, October). Using Quantitative Ethnography to Investigate Self-Assessments of Progressive Entrustment in Surgery Education. In Eagan, B., Misfeldt, M., Siebert-Evenstone, A. First International Conference on Quantitative Ethnography: Conference Proceedings Supplement Gender Differences in Entrustable Professional Activity Evaluations of General Surgery Residents. (Under review). Changing medical education when change is hard: implementing an interdepartmental entrustable professional activity. (In press). AEM Education and Training. Stahl, C. C., Collins, E., Jung, S., Rosser, A. A., Kraut, A. S., Schnapp, B. H., ... & Greenberg, J. A. (2020). Entrustable Professional Activities in General Surgery: Trends in Resident Self-Assessment. Journal of Surgical Education	Yes	Sarah Pavao - pavao@surgery.wisc.edu	Entrustable Professional Activities in Surgery: Utilizing Microassessments and Feedback: The student will work with the research mentor as well as residents and surgeons in the Department of Surgery to continue facilitate the collection of EPA microassessments using a smartphone-based app. However, just over 3000 microassessments have already been collected from faculty and residents and will be used for both quantitative and qualitative analysis of trends in residents' progression through surgery training. ____________________________________________________________________________ Role - Data organization, cleaning, and analysis. Abstract writing. Presentation of results. Manuscript preparation.; IRB Status - Approved; Skills - Use of spreadsheets for data cleaning and organization	Sarah Jung, jungs@surgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueyogk8IUfSdJS8whak6e7XdAMSyMwf5mAfetAfW1fhUtupprvPjbfncDOWUaEQJcA
04/01/2021	zmorris@humonc.wisc.edu	Zachary	Morris	MD/PhD	Assistant Professor	6.082.632.603	Human Oncology								Evaluating mechanisms of interaction between radiation therapies and immunotherapies	Preclinical and clinical investigations of therapeutic mechanisms whereby radiation may enhance response to immunotherapies. Specific study details can be tailored to the interests and goals of the student.	0	Perform laboratory research and analyses.	Supervision provided by senior member of the Morris lab.	Basic laboratory skills, ideally including mammalian cell culture, PCR, mouse handling, and/or flow cytometry	N/A	Yes	Yes	Yes	Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Jagodinsky JC, Morris ZS. Priming and Propagating Anti-tumor Immunity: Focal Hypofractionated Radiation for in Situ Vaccination and Systemic Targeted Radionuclide Theranostics for Immunomodulation of Tumor Microenvironments. Semin Radiat Oncol. 2020 Apr;30(2):181-186. doi: 10.1016/j.semradonc.2019.12.008. PMID: 32381297. Patel RB, Ye M, Carlson PM, Jaquish A, Zangl L, Ma B, Wang Y, Arthur I, Xie R, Brown RJ, Wang X, Sriramaneni R, Kim K, Gong S, Morris ZS. Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial-Membrane-Coated Nanoparticles. Adv Mater. 2019 Oct 31(43):e1902626. doi: 10.1002/adma.201902626. Epub 2019 Sep 16. PMID: 31523868. Baniel CC, Heinze CM, Hoefges A, Sumiec EG, Hank JA, Carlson PM, Jin WJ, Patel R, Sriramaneni RN, Gillies SD, Erbe AK, Schwarz CN,Pieper AA, Rakhmilevich AL, Sondel PM and Morris ZS. In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response. Front. Immunol. 2020. Jul 24;11:1610. doi: 10.3389/fimmu.2020.01610. PMID: 32849544. Clark PA, Sriramaneni RN, Jin WJ, Jagodinsky JC, Bates AM, Jaquish AA, Anderson BR, Le T, Lubin JA, Chakravarty I, Arthur IA, Heinze CM, Guy EI, Kler J, Klar KA, Carlson PM, Kim K, Kuo JS, Morris ZS. In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases. J Immunother Cancer. 2020 Jul;8(2):e000809. doi: 10.1136/jitc-2020-000809.PMID: 32690669. Jin WJ, Erbe AK, Schwarz CN, Jaquish AA, Anderson BR, Sriramaneni RN, Jagodinsky JC, Bates AM, Clark PA, Le T, Lan KH, Chen Y, Kim KM, Morris ZS. Tumor-specific antibody, cetuximab, enhances the in situ vaccine effect of radiation in immunologically cold head and neck squamous cell carcinoma. Front Immunol. 2020 Nov 12;11:591139. doi: 10.3389/fimmu.2020.591139. PMID: 33281820.	Yes	Raghava Sriramaneni	Evaluating mechanisms of interaction between radiation therapies and immunotherapies: Preclinical and clinical investigations of therapeutic mechanisms whereby radiation may enhance response to immunotherapies. Specific study details can be tailored to the interests and goals of the student. ____________________________________________________________________________ Role - Perform laboratory research and analyses.; IRB Status - N/A; Skills - Basic laboratory skills, ideally including mammalian cell culture, PCR, mouse handling, and/or flow cytometry	Zachary Morris, zmorris@humonc.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf5eGe2xzjkWhyQsaidrSFKzgnrIV_ymbObXwJSmlauddtl0xwS6f3YZn9bQfKPqwo
05/01/2021	hanna@neurosurgery.wisc.edu	Amgad	Hanna	MD	Associate Professor	6.082.658.800	Neurological Surgery				Daniel Hellenbrand, Assistant Researcher	Hellenbrand@neurosurgery.wisc.edu	Neurological Surgery		Modulating inflammation after spinal cord injury	Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S., costing the health care system $40.5 billion annually. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. Inflammatory cytokines are strongly upregulated during the first 24 hours after SCI, and there is a second wave of inflammatory cytokine expression around 14 days. Using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, however, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood-spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of anti-inflammatory cytokines, coinciding with critical stages of the ensuing inflammatory response, given directly in the injury site for at least 14 days. Here we are proposing a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI. We will use a proven drug delivery platform to bind and release three anti-inflammatory cytokines after SCI in a rat and measure the effects on inflammation, lesion size, and hind limb function of the rat.	2	This is a large ongoing project that will not be finished over the summer. The students will be involved in a lot of hands on surgeries and experiments. The rat surgeries include spinal cord contusion, electrophysiology, craniotomies for axon tracer injection, and perfusions. Other experiments include rat functional testing, sectioning spinal cord, and immunohistochemistry.	The student will usually work directly with Dan Hellenbrand and a team of students, but sometimes will be working independently.	There are no skills required. The student will need to take several safety and training courses to work in the lab. Most of these courses are just online, but rat handling and rat surgery need to be done in person through the RARC. If you are interested, we can discuss safety and training more in person.	n/a	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	PhD students, UW undergraduates interested in research	Hellenbrand DJ, Reichl KA, Travis BJ, Filipp ME, Khalil AS, Pulito DJ, Gavigan AV, Maginot ER, Arnold MT, Adler AG, Murphy WL, Hanna AS (2019) Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury. Journal of neuroinflammation 16:93. Hellenbrand D, Haldeman C, Lee J-S, Gableman A, Dai E, Ortmann S, Gotchy J, Miller K, Doucas A, Nowak N, Murphy W, Hanna A (2021) Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles. Neural regeneration research 16:871-877. Hellenbrand DJ, Hanna A (2016) Treating spinal cord injury via sustained drug delivery from calcium phosphate coatings. Neural regeneration research 11:1236-1237. Hanna A, Thompson DL, Hellenbrand DJ, Lee JS, Madura CJ, Wesley MG, Dillon NJ, Sharma T, Enright CJ, Murphy WL (2016) Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury. Journal of neuroscience research 94:645-652. Thompson CD, Zurko JC, Hanna BF, Hellenbrand DJ, Hanna A (2013) The Therapeutic Role of Interleukin-10 after Spinal Cord Injury. Journal of neurotrauma 30:1311-1324.	No	Daniel Hellenbrand, hellenbrand@neurosurgery.wisc.edu	Modulating inflammation after spinal cord injury: Spinal Cord Injury (SCI) is a devastating trauma that leaves approximately 10,000 to 20,000 people paralyzed every year in the U.S., costing the health care system $40.5 billion annually. After SCI, there is immediate mechanical damage followed by a cascade of cellular and molecular responses leading to infiltration of immune cells. Although it has been shown that the inflammatory response after SCI is beneficial in removing debris and releasing neurotrophic factors, there is an overreaction of the inflammatory response causing further neural destruction and inflammatory macrophages remain for a prolonged time period. Inflammatory cytokines are strongly upregulated during the first 24 hours after SCI, and there is a second wave of inflammatory cytokine expression around 14 days. Using anti-inflammatory cytokines to attenuate inflammation after SCI has shown some encouraging results, however, there are several limitations that need to be overcome to use anti-inflammatory cytokines as a treatment for SCI including, a short half-life, inability to cross the blood-spinal cord barrier, rapid clearance from the injury site, and higher risk of infection when using large systemic doses. Therefore, it would be beneficial to have a local sustained delivery of anti-inflammatory cytokines, coinciding with critical stages of the ensuing inflammatory response, given directly in the injury site for at least 14 days. Here we are proposing a novel drug delivery method to administer anti-inflammatory cytokines for 14 days to reduce inflammation and reduce the amount of function lost after SCI. We will use a proven drug delivery platform to bind and release three anti-inflammatory cytokines after SCI in a rat and measure the effects on inflammation, lesion size, and hind limb function of the rat. ____________________________________________________________________________ Role - This is a large ongoing project that will not be finished over the summer. The students will be involved in a lot of hands on surgeries and experiments. The rat surgeries include spinal cord contusion, electrophysiology, craniotomies for axon tracer injection, and perfusions. Other experiments include rat functional testing, sectioning spinal cord, and immunohistochemistry. ; IRB Status - n/a; Skills - There are no skills required. The student will need to take several safety and training courses to work in the lab. Most of these courses are just online, but rat handling and rat surgery need to be done in person through the RARC. If you are interested, we can discuss safety and training more in person.	Amgad Hanna, hanna@neurosurgery.wisc.edu -- Co-Mentor: Daniel Hellenbrand, Assistant Researcher Hellenbrand@neurosurgery.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufr8dKf48iewxNtaNbTN6Pd7R2IetZyiyO6S8s5v2ctBSkATa-JDONFkMnIUXb0cHE
05/01/2021	kmajumder@wisc.edu	Kinjal	Majumder	PhD	Assistant Professor of Oncology	608	Oncology	Cancer Virology	Other	Institute for Molecular Virology					How do oncolytic DNA viruses establish replication centers in host cells?	Viral infection of hosts induces a cellular DNA damage response (DDR) which can inhibit or facilitate viral replication. Small DNA viruses replicate in nuclear replication centers that colocalize with cellular DDR markers, but how these replication centers are formed and sustained remains unknown. Using the oncolytic protoparvovirus MVM as a model system, we adapted chromosome conformation capture assays (dubbed V3C-seq) to map where non-integrating MVM genomes localize. We found that the MVM genome localizes to cellular sites of DNA damage, many of which are early replicating fragile sites from where oncogenic translocations can arise. The viral non-structural phosphoprotein NS1 binds and transports the MVM genome to these cellular DDR sites. However, the cellular proteins that facilitate this localization remain unknown. We have recently found that the DNA repair protein MRE11, involved in initiating DDR signals, binds to the viral genome, suggesting that it might play a role in facilitating the formation of viral replication centers. The goal of this project will be to investigate how the DNA repair protein MRE11 regulates the establishment of nuclear replication centers. More information on the Majumder lab can be found at: https://majumder.wiscweb.wisc.edu/research/	1	The student will perform experiments studying the binding of MRE11 to the viral genome (chromatin immunoprecipitation combined with qPCR), association of MRE11 with viral and cellular proteins (co-IP) and induction of cellular DNA damage signals (western blots, confocal imaging). The student will be trained directly by the PI, and will work closely with the PI on these experiments.	Moderate to high independence	Critical thinking skills and moderate molecular biology experience	Approved (11/4/2020)	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs Boftsi M, Majumder K, Burger LR, Pintel DJ. Viruses. 2020 Nov 30; 12(12):1368. doi: 10.3390/v12121368. PMID: 33266080 The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage. Majumder K, Boftsi M, Whittle FB, Wang J, Fuller MS, Joshi T, Pintel DJ. PLoS Pathog. 2020 Oct 16;16(10):e1009002. doi: 10.1371/journal.ppat.1009002. PMID: 33064772 Viral Chromosome Conformation Capture (V3C) Assays for Identifying Trans-interaction Sites between Lytic Viruses and the Cellular Genome. Majumder K, Boftsi M, Pintel DJ. Bio Protoc. 2019 Mar 20;9(6):e3198. doi: 10.21769/BioProtoc.3198. PMID: 31032382 Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. Majumder K, Wang J, Boftsi M, Fuller MS, Rede JE, Joshi T, Pintel DJ. Elife. 2018 Jul 20;7:e37750. doi: 10.7554/eLife.37750. PMID: 30028293 Protoparvovirus Interactions with the Cellular DNA Damage Response. Majumder K, Etingov I, Pintel DJ. Viruses. 2017 Oct 31;9(11):323. doi: 10.3390/v9110323. PMID: 29088070	Yes	Kim Voss (krvoss@wisc.edu)	How do oncolytic DNA viruses establish replication centers in host cells?: Viral infection of hosts induces a cellular DNA damage response (DDR) which can inhibit or facilitate viral replication. Small DNA viruses replicate in nuclear replication centers that colocalize with cellular DDR markers, but how these replication centers are formed and sustained remains unknown. Using the oncolytic protoparvovirus MVM as a model system, we adapted chromosome conformation capture assays (dubbed V3C-seq) to map where non-integrating MVM genomes localize. We found that the MVM genome localizes to cellular sites of DNA damage, many of which are early replicating fragile sites from where oncogenic translocations can arise. The viral non-structural phosphoprotein NS1 binds and transports the MVM genome to these cellular DDR sites. However, the cellular proteins that facilitate this localization remain unknown. We have recently found that the DNA repair protein MRE11, involved in initiating DDR signals, binds to the viral genome, suggesting that it might play a role in facilitating the formation of viral replication centers. The goal of this project will be to investigate how the DNA repair protein MRE11 regulates the establishment of nuclear replication centers. More information on the Majumder lab can be found at: https://majumder.wiscweb.wisc.edu/research/ ____________________________________________________________________________ Role - The student will perform experiments studying the binding of MRE11 to the viral genome (chromatin immunoprecipitation combined with qPCR), association of MRE11 with viral and cellular proteins (co-IP) and induction of cellular DNA damage signals (western blots, confocal imaging). The student will be trained directly by the PI, and will work closely with the PI on these experiments. ; IRB Status - Approved (11/4/2020); Skills - Critical thinking skills and moderate molecular biology experience	Kinjal Majumder, kmajumder@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueFFCObSPJwbf3EhMTuqPGfxHiTTY_kp7VRQ_-bdgorS8w7mC_r8Mu96C7ClucqszE
05/01/2021	mrwolff@medicine.wisc.edu	Matthew	Wolff	MD	Professor of Medicine (CHS)	608	Medicine	Cardiovascular Medicine			Timothy Hacker, Ph.D, Senior Scientist and Director, Animal Model Core Lab, SMPH	Th2@medicine.wisc.edu	Other	Core lab in SMPH	Cardiac function and imaging	The combined laboratories of Matthew Wolff, MD, Professor (CHS), Cardiovascular Medicine and Timothy Hacker, PhD, Senior Scientist and Director, Animal Model Core Lab, School of Medicine and Public Health, have several exciting research options for Shapiro Summer Research Program Awardees: 1. Small Animal Cardiac Ultrasound Imaging Our lab recently obtained a new small animal ultrasound machine (FujiFilm Visual Sonics, Vevo 3100). This machine is a significant upgrade from our old machine, with several new features which need to be validated. We are particularly excited about two new features: 1) four-dimensional cardiac ultrasound, which captures the typical three spatial dimensions over one complete cardiac cycle at 100-300 frames per second and 2) strain, or the measure of tissue deformation over time, which is a clinically important measure of cardiac function, particularily early in cardiac disease. For this project the student’s role would be to help design and implement experiments to validate these new features in various mouse models of cardiovascular disease. In addition, the student would help prepare for and assist with mouse surgeries to create animal models of disease, ultrasound imaging and assist with data collection and analysis. This work is highly likely to result in a student project suitable for presentation at a national meeting and publication. 2. Novel nanogenerator cardiac pacemaker development in anesthetized swine Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. We plan to test the optimal location on the heart for maximal power output. For your project we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The student’s role would be to help with data collection and analysis, prepare for and assist with animal surgeries to place the device, blood collections, ultrasound imaging, ECG, and invasive physiological data collection. This work is less likely to generate a publication for the student. 3. Mechanisms of cardiac dysfunction and therapeutic recovery in an animal model of a familial dilated cardiomyopathy. We have maintained a colony of lmnaN195K/N175K mice, a murine model of a familial (genetic) dilated cardiomyopathy (FDC or genetic DCM) related to a lamin mutation (specifically lmnaN195K/WT). This model recapitulates the disease phenotype seen in the human familial DCM, including cardiac dilation, reduced cardiac output and ventricular ejection fraction, premature death, etc… We have also shown that 2 drugs prolong survival in this murine model: the p38 MAPK inhibitor A371797 and the mTORC1 inhibitor sirolimus (rapamycin). Based in large part on pre-clinical work from our laboratory, A371797 is now in a phase III multinational trial for lamin-associated FDC. However, the subcellular mechanism of action of A371797 remains unclear. We plan on looking at gene expression and phosphorylation of key proteins in the MAPK pathways as well as markers of autophagy and apoptosis in this model, with or without treatment, by Western blotting and other techniques. We will also construct a pressure overload model of heart failure in minimally affected heterozygotic mice (lmnaN195K/WT) created by surgical constriction of the thoracic aorta (TAC procedure). These mice, and controls will be examined by cardiac ultrasonography as described in project 2, and subcellar mechanisms will be examined by Western blotting.	2	major role in proposed research, with expected presentation/publication for all projects except the swine pacemaker study	Moderate, although we will train	spreadsheet skills necessary, Western blotting skills desirable for 3rd project	approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	DPT students, Genetic Counseling students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Fatkin et al, Missense mutations in the rod domain of the lamination's A/C gene as causes of dilated cardiomyopathy and conduction system disease. NEJM 1999; 341:1715-24. Markandeya et al, Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation. Heart Rhythm 2016; 11:2228-36 Hacker TA, Animal Models and Cardiac Extracellular Matrix Research, Adv Exp Med Biol., 2018; 1098: 45-48 Kumari et al, Biomodal right ventricular dysfunction after postnatal hyperopia exposure: implications for the preterm heart. Am J Physiology Circ Physiol. 2019; 317; H1272-H1281	Yes	N?A	Cardiac function and imaging: The combined laboratories of Matthew Wolff, MD, Professor (CHS), Cardiovascular Medicine and Timothy Hacker, PhD, Senior Scientist and Director, Animal Model Core Lab, School of Medicine and Public Health, have several exciting research options for Shapiro Summer Research Program Awardees: 1. Small Animal Cardiac Ultrasound Imaging Our lab recently obtained a new small animal ultrasound machine (FujiFilm Visual Sonics, Vevo 3100). This machine is a significant upgrade from our old machine, with several new features which need to be validated. We are particularly excited about two new features: 1) four-dimensional cardiac ultrasound, which captures the typical three spatial dimensions over one complete cardiac cycle at 100-300 frames per second and 2) strain, or the measure of tissue deformation over time, which is a clinically important measure of cardiac function, particularily early in cardiac disease. For this project the student’s role would be to help design and implement experiments to validate these new features in various mouse models of cardiovascular disease. In addition, the student would help prepare for and assist with mouse surgeries to create animal models of disease, ultrasound imaging and assist with data collection and analysis. This work is highly likely to result in a student project suitable for presentation at a national meeting and publication. 2. Novel nanogenerator cardiac pacemaker development in anesthetized swine Revolutionary advancements in pacemakers include a miniaturized and leadless design and intracardiac implantation. However, the bulky and rigid battery creates the largest hurdle towards further development of a soft system that can be attached and conform to tissue and muscle surfaces without causing unwanted physiologic changes. To address this critical challenge, this project proposes to develop a self-sustainable power source (SSPS) for intracardiac pacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator (i-NG) with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project focuses on designing and validating a SSPS specifically for powering intracardiac pacemakers by harvesting energy from heartbeats. We plan to test the optimal location on the heart for maximal power output. For your project we will characterize electrical output of SSPS in vivo epicardially in different locations and orientations on the epicardial surface of the right ventricle (RV) of swine hearts. Cardiac function will be monitored over time to ensure SSPS implantation does not alter heart function. The student’s role would be to help with data collection and analysis, prepare for and assist with animal surgeries to place the device, blood collections, ultrasound imaging, ECG, and invasive physiological data collection. This work is less likely to generate a publication for the student. 3. Mechanisms of cardiac dysfunction and therapeutic recovery in an animal model of a familial dilated cardiomyopathy. We have maintained a colony of lmnaN195K/N175K mice, a murine model of a familial (genetic) dilated cardiomyopathy (FDC or genetic DCM) related to a lamin mutation (specifically lmnaN195K/WT). This model recapitulates the disease phenotype seen in the human familial DCM, including cardiac dilation, reduced cardiac output and ventricular ejection fraction, premature death, etc… We have also shown that 2 drugs prolong survival in this murine model: the p38 MAPK inhibitor A371797 and the mTORC1 inhibitor sirolimus (rapamycin). Based in large part on pre-clinical work from our laboratory, A371797 is now in a phase III multinational trial for lamin-associated FDC. However, the subcellular mechanism of action of A371797 remains unclear. We plan on looking at gene expression and phosphorylation of key proteins in the MAPK pathways as well as markers of autophagy and apoptosis in this model, with or without treatment, by Western blotting and other techniques. We will also construct a pressure overload model of heart failure in minimally affected heterozygotic mice (lmnaN195K/WT) created by surgical constriction of the thoracic aorta (TAC procedure). These mice, and controls will be examined by cardiac ultrasonography as described in project 2, and subcellar mechanisms will be examined by Western blotting. ____________________________________________________________________________ Role - major role in proposed research, with expected presentation/publication for all projects except the swine pacemaker study; IRB Status - approved; Skills - spreadsheet skills necessary, Western blotting skills desirable for 3rd project	Matthew Wolff, mrwolff@medicine.wisc.edu -- Co-Mentor: Timothy Hacker, Ph.D, Senior Scientist and Director, Animal Model Core Lab, SMPH Th2@medicine.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf0spsndZGiBWDmqrgZVBQMhXdVQJdrdd-XKOZZq7hE4rX7knv0PlpNp34TnXjHoUM
05/01/2021	baschnagel@humonc.wisc.edu	Andrew	Baschnagel	M.D.	Associate Professor	608	Human Oncology								Radiomics-Based Deep Learning to Identify MRI Predictive Features in Patients with Brain Metastases	This project will analyze radiomic features from MRIs of patients with brain metastases treated with radiation and immunotherapy. The goal is to discover features that could predict recurrence and/or radiation necrosis. Deep leaning algorithms will be used to analyze the data. In addition, in a subset up patients, we will see if genomic features of the tumors correlate with radiomic imaging features. There is also the option to assist in writing a clinical protocol. This project is open to all students but may be of interest to those considering specializing in oncology, radiation oncology, radiology, neurosurgery or neurology. Past medical students have been successful in writing up results for national abstracts and being first author on published papers.	0	The student will assist in collecting clinical data from patient's electronic charts, reviewing radiation treatment plans and analyzing radiomic data.		excel	IRB is approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	MPH students, PhD students, UW undergraduates interested in research	https://pubmed.ncbi.nlm.nih.gov/33281062/ https://pubmed.ncbi.nlm.nih.gov/30861275/	No	N/A	Radiomics-Based Deep Learning to Identify MRI Predictive Features in Patients with Brain Metastases: This project will analyze radiomic features from MRIs of patients with brain metastases treated with radiation and immunotherapy. The goal is to discover features that could predict recurrence and/or radiation necrosis. Deep leaning algorithms will be used to analyze the data. In addition, in a subset up patients, we will see if genomic features of the tumors correlate with radiomic imaging features. There is also the option to assist in writing a clinical protocol. This project is open to all students but may be of interest to those considering specializing in oncology, radiation oncology, radiology, neurosurgery or neurology. Past medical students have been successful in writing up results for national abstracts and being first author on published papers. ____________________________________________________________________________ Role - The student will assist in collecting clinical data from patient's electronic charts, reviewing radiation treatment plans and analyzing radiomic data.; IRB Status - IRB is approved; Skills - excel	Andrew Baschnagel, baschnagel@humonc.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufCilqtLyidZI_FAlxTy526WtEy7YfYzpCJl4PDV8FILqtYEfSekiqyvf9OW8w8Eas
05/01/2021	watson@ortho.wisc.edu	Drew	Watson	MD, MS	Assistant Professor	6.082.636.647	Orthopedics and Rehabilitation	Sports Medicine	Pediatrics						Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children	The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy 12-14 year old are currently being recruited for participation. Testing includes determination of height, weight, body composition by whole body MRI, maximal oxygen consumption by cycle ergometry, and cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates.We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the right ventricle and the ventricular response to exercise. Lab website: https://ortho.wisc.edu/research/labs/watson/	0	Students will be actively involved in reviewing the current literature relevant to this project, as well as data collection, management, and analysis. This will include hands-on data collection from participants during maximal exercise testing and cardiac MRI. It is expected that this will culminate in the development of an abstract eligible for submission to a national scientific meeting and a possible peer-reviewed manuscript if interested. In the event that data collection is delayed or prevented by COVID-19 additional projects are available utilizing existing data previously collected from other projects including risk factors for injuries in athletes, the psychosocial impacts of injuries, COVID-19 risk in sports, and others.	Considerable independence is expected and much of the work not related to data collection will be conducted remotely.	Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. Data collection techniques will be taught through supervise dlearning during study data collections.	Approved	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	PhD students	Haraldsdottir H, Watson AM, Pegelow DF, Palta M, Tetri LH, Levin TS, Brix MD, Centanni RM, Goss KN, Eldridge MM. Blunted cardiac exercise response in preterm children. Eur J Appl Phys 2020, ePub ahead of print. Goss KN, Haraldsdottir K, Beshish AG, Barton GP, Macdonald JA, Levin TS, Watson AM, Palta M, Chesler NC, Francois CJ, Wieben O, Eldridge MW. Biventricular inefficiency in adults born preterm. JAMA Cardiology 2020 (ePub ahead of print). Haraldsdottir K, Watson AM, Beshish AG, Pegelow DF, Palta M, Tetri LH, Brix MD, Centanni, RM, Goss, KN, Eldridge MW. Heart Rate Recovery After Maximal Exercise Is Impaired in Healthy Young Adults Born Preterm. Eur J Appl Physiol 2019 (Epub Ahead of Print). Watson A, Coutinho C, Haraldsdottir K, Brickson S, Dunn W, Eldridge M. In-Season Changes in Ventricular Morphology and Systolic Function in Adolescent Female Athletes. Eur J Sports Sci 2018:534-540. Haraldsdottir K, Watson AM, Goss KN, Beshish AG, Pegelow DF, Palta M, Tetri LH, Barton GP, Brix MD, Centanni RM, Eldridge MW. Impaired Autonomic Function in Adolescents Born Preterm. Phys Rep:2018;6:e13620. Watson A, Eickhoff J, Nemeth B, Carell A. In Non-Obese Children, BMI and Fitness Are Independently Related to Insulin Sensitivity. Pediatr Exerc Sci Apr 2015;27:203-7.	No	Angela Riesing (riesing@ortho.wisc.edu	Effects of Physical Fitness and Obesity on Cardiac Morphology and Function in Children: The effects of childhood obesity and physical inactivity on the pediatric heart remain unclear. By using novel, innovative cardiac MRI techniques that allow real-time physiologic imaging at rest and during exercise, our goal is to define the independent influences of CRF and body composition on ventricular morphology and function in children. Healthy 12-14 year old are currently being recruited for participation. Testing includes determination of height, weight, body composition by whole body MRI, maximal oxygen consumption by cycle ergometry, and cardiac MRI at rest and during exercise at 70% of maximal capacity to determine LV and RV volume, mass, stroke volume, and ejection fraction, as well as aortic stiffness and pulmonary vascular compliance. Separate multivariable regression models will be used to identify independent predictors of RV and LV volume, mass, and function using CRF and body fat as covariates.We expect our findings will significantly advance our understanding of the effects of exercise and obesity on cardiac size and function during early adolescence, particularly with respect to the right ventricle and the ventricular response to exercise. Lab website: https://ortho.wisc.edu/research/labs/watson/ ____________________________________________________________________________ Role - Students will be actively involved in reviewing the current literature relevant to this project, as well as data collection, management, and analysis. This will include hands-on data collection from participants during maximal exercise testing and cardiac MRI. It is expected that this will culminate in the development of an abstract eligible for submission to a national scientific meeting and a possible peer-reviewed manuscript if interested. In the event that data collection is delayed or prevented by COVID-19 additional projects are available utilizing existing data previously collected from other projects including risk factors for injuries in athletes, the psychosocial impacts of injuries, COVID-19 risk in sports, and others.; IRB Status - Approved; Skills - Familiarity with basic word processing and database software programs, as well as basic scientific writing skills. Data collection techniques will be taught through supervise dlearning during study data collections.	Drew Watson, watson@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucRmFAyN8PjHzsVoqQzFGrg91aOWpWHhPeUWw5uyF_1YHu0RsfgWMgyKL-VrFY0By8
06/01/2021	abbott@surgery.wisc.edu	Daniel	Abbott	MD	Associate Professor of Surgery	608	Surgery	Surgical Oncology							Identifying variabilit of resource utilization in Surgical Oncology	I perform health services research, specifically identifying drivers of, and variability in, cost and resource utilization across surgical procedures. The student would pick from a wide variety of potential project, tailored to their individual goals.	0	The student would be as independent as possible. The work would likely include chart review, performance of basic statistics, critical thinking and analysis of the data/results, and ideally be the first author on a manuscript prepared by them		Would be helpful if there was some basic understanding of spreadsheets and basic statistical methods	Already have approval	No	Perhaps, but would greatly prefer to use Dean's Office Funds	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students, But please keep checking back	Not currently available to mentor other students	Here are 5 from the last year. If you need more than this let me know, but there are 20+ over the last 5 years that are relevant 1. Intercostal nerve cryoablation is associated with lower hospital cost during minimally invasive Nuss procedure for pectus excavatum. Aiken TJ, Stahl CC, Lemaster D, Casias TW, Walker BJ, Nichol PF, Leys CM, Abbott DE, Brinkman AS. 2. A telephone-based surgical transitional care program with improved patient satisfaction scores and fiscal neutrality. Schreiter NA, Fisher A, Barrett JR, Acher A, Sell L, Edwards D, Leverson G, Joachim A, Weber SM, Abbott DE. 3. Surgeon Variability Impacts Costs in Laparoscopic Cholecystectomy: the Volume-Cost Relationship. Stahl CC, Udani S, Schwartz PB, Aiken T, Acher AW, Barrett JR, Greenberg JA, Abbott DE. 4. Early vs Late Readmissions in Pancreaticoduodenectomy Patients: Recognizing Comprehensive Episodic Cost to Help Guide Bundled Payment Plans and Hospital Resource Allocation. Acher AW, Barrett JR, Schwartz PB, Stahl C, Aiken T, Ronnekleiv-Kelly S, Minter RM, Leverson G, Weber S, Abbott DE. 5. What Drives High Costs of Cytoreductive Surgery and HIPEC: Patient, Provider or Tumor?	No	N/A	Identifying variabilit of resource utilization in Surgical Oncology: I perform health services research, specifically identifying drivers of, and variability in, cost and resource utilization across surgical procedures. The student would pick from a wide variety of potential project, tailored to their individual goals. ____________________________________________________________________________ Role - The student would be as independent as possible. The work would likely include chart review, performance of basic statistics, critical thinking and analysis of the data/results, and ideally be the first author on a manuscript prepared by them; IRB Status - Already have approval; Skills - Would be helpful if there was some basic understanding of spreadsheets and basic statistical methods	Daniel Abbott, abbott@surgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueOp9zcogL8zQqeh0vqkmKv22T7FI5f_CW8nAMwFqx0fV3VcAKSlZE-VA3IM659BRs
25/01/2021	brooks@ortho.wisc.edu	Alison	Brooks	MD MPH	Associate Professor		Orthopedics and Rehabilitation	Sports Medicine							UW-Madison Youth Soccer Header Study	Despite the large popularity of soccer worldwide and in the US, the majority of research on sport-related head impacts has been concentrated in male American football players using head-impact measurement sensors in instrumented football helmets. The limited research in soccer players likewise has focused on males, particularly those playing at an elite level, such as collegiate or professional. Unfortunately there is a paucity of data on youth soccer athletes in regards to how these younger players actually head the ball and what forces they experience. Measurement of head impacts is essential to further understanding the potential risks associated with heading in youth soccer, and to further inform rule or policy changes that limit head impact exposure in these younger age groups. Specific Aim: Establish and validate age-based head kinematics, force-strain models and brain injury probability maps from sensor worn data during soccer heading tasks. In this study, age-and sex-specific force strain models will be validated using a study of soccer headers under controlled conditions. Youth soccer players in 6th-12th grade will be recruited to participate in a header training session while wearing motion sensor headbands. All children will undergo MRI scanning and baseline assessment of neurocognitive function, psychological health, and academic aptitude and performance. Subject-specific finite element models will be created from MRI scans, and principle tissue strains will be determined based on head motion profiles during soccer headers and compared between age- and sex-specific groups	0	Students will be actively involved in reviewing the current literature relevant to this project, as well as subject recruitment and screening, data collection, management, and analysis. This will include hands-on in-person data collection from subjects during soccer heading sessions and brain MRI. Abstract writing and submission to a national scientific meeting and a possible peer-reviewed manuscript are possible for motivated and interested students		Familiarity with basic word processing and database software programs such as MS Excel and REDCap; Basic scientific writing skills; Interpersonal skills to interact with potential subjects and their parents; Specific data collection procedures will be taught through supervised data collection sessions with study Research Specialist	Under Review	Internal Funding through VCRGE	Yes	Yes	Interested and funded to provide another yearlong mentoring opportunity	Not currently available to mentor other students	McGuine TA, Post E, Pfaller AY, Hetzel S, Schwarz A, Brooks MA, Kliethermes SA. Does Soccer Headgear Reduce the Incidence of Sport-Related Concussion? A Cluster-Randomised Controlled Trial of Adolescent Athletes. British Journal of Sports Medicine 2020; 54:408-413. doi: 10.1136/bjsports-2018-100238. PMID:31088784	Yes	Angela Riesing, 608-263-6477, riesing@ortho.wisc.edu	UW-Madison Youth Soccer Header Study: Despite the large popularity of soccer worldwide and in the US, the majority of research on sport-related head impacts has been concentrated in male American football players using head-impact measurement sensors in instrumented football helmets. The limited research in soccer players likewise has focused on males, particularly those playing at an elite level, such as collegiate or professional. Unfortunately there is a paucity of data on youth soccer athletes in regards to how these younger players actually head the ball and what forces they experience. Measurement of head impacts is essential to further understanding the potential risks associated with heading in youth soccer, and to further inform rule or policy changes that limit head impact exposure in these younger age groups. Specific Aim: Establish and validate age-based head kinematics, force-strain models and brain injury probability maps from sensor worn data during soccer heading tasks. In this study, age-and sex-specific force strain models will be validated using a study of soccer headers under controlled conditions. Youth soccer players in 6th-12th grade will be recruited to participate in a header training session while wearing motion sensor headbands. All children will undergo MRI scanning and baseline assessment of neurocognitive function, psychological health, and academic aptitude and performance. Subject-specific finite element models will be created from MRI scans, and principle tissue strains will be determined based on head motion profiles during soccer headers and compared between age- and sex-specific groups ____________________________________________________________________________ Role - Students will be actively involved in reviewing the current literature relevant to this project, as well as subject recruitment and screening, data collection, management, and analysis. This will include hands-on in-person data collection from subjects during soccer heading sessions and brain MRI. Abstract writing and submission to a national scientific meeting and a possible peer-reviewed manuscript are possible for motivated and interested students; IRB Status - Under Review; Skills - Familiarity with basic word processing and database software programs such as MS Excel and REDCap; Basic scientific writing skills; Interpersonal skills to interact with potential subjects and their parents; Specific data collection procedures will be taught through supervised data collection sessions with study Research Specialist	Alison Brooks, brooks@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufCoCLzPNSGpQG-aQ71R2yNG4-axHzFiphMxXN9DUVP58Tfq8eadut3b9HDRlfdXdI
06/01/2021	kschaumberg@wisc.edu	Katherine	Schaumberg	PhD	Dr	9.192.449.415	Psychiatry								The role of exercise in eating disorders	Involvement in data collection and data management of a study investigating the role of exercise in eating disorders. https://embark.psychiatry.wisc.edu	0	Data collection; data management; potentially some analysis	some independence	None required. Coding in Python, SQL, and R a plus	Approved	Yes	No (plan to use Dean's Office Funds)	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, UW undergraduates interested in research	https://osf.io/q6muy	Yes	Art Walaszak	The role of exercise in eating disorders: Involvement in data collection and data management of a study investigating the role of exercise in eating disorders. https://embark.psychiatry.wisc.edu ____________________________________________________________________________ Role - Data collection; data management; potentially some analysis; IRB Status - Approved; Skills - None required. Coding in Python, SQL, and R a plus	Katherine Schaumberg, kschaumberg@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf7xp_ISsm41-nC4EH5CpXpN-ep6hma1ellllfnFYKjj6s-ec_ysuHgfLSetoHQAkY
19/01/2021	kantony@wisc.edu	Kathleen	Antony	MD, MSCI	Assistant Professor	6.084.175.971	Obstetrics & Gynecology	Maternal-Fetal Medicine							Assessment of in-hospital pain control after delivery and its correlation with anxiety in the immediate and long-term postpartum period	While postpartum depression has become increasingly screened for, postpartum anxiety has not been as widely studied, despite a higher estimated incidence between 24.9-28.9%. Further characterization is needed about maternal perspectives on pain control postpartum with the implications that inadequate control has on emotional recovery, physical recovery, and maternal mental health. The aim of this study is to identify the role of post-delivery pain control in the development of postpartum anxiety by using surveys that are specific to the postpartum period. The survey at time of discharge will include a modification of the GAD-7 questionnaire and American Pain Society Patient Outcome Questionnaire (APSPOQ) while the survey at 6 weeks will be the GAD-7.	0	The student’s roles here will include 1. Approaching women admitted to the postpartum floor and requesting permission from the women (via signature and email address being recorded on a form) to have a survey emailed to them about anxiety (or alternatively, assuming COVID restrictions remain in place, calling the patient’s nurse and inquiring about whether the patient is willing to receive a call in her hospital room to discuss the project and then calling the patient in her hospital room and obtaining the patient’s name and email address via phone. A second alternative is having the resident physicians obtain permission to contact with an email address and phone number and having the student retrieve these forms) 2. Entering the email address into REDCap to send the questionnaire (the follow-up questionnaire will automatically send 6 weeks later), and 3. Entering clinical data about the postpartum women into the REDCap database. Of note, the consent is contained within the first page of the questionnaire as an “agree to proceed” or not which either prompts the questionnaire or a closing of questionnaire, respectively. During the summer Shapiro rotation, discharge survey data would become available and would be able to be analyzed during the summer for submission to a national OB/GYN meeting with an October deadline. The student would have the opportunity to be the first author on an abstract submitted to a national OB/GYN meeting (ACOG) and could present the poster there in April or May of 2022. The student would also have the opportunity to be first author on the manuscript of discharge survey data and, if desired, the 6 week postpartum survey data. The student would also be expected to present findings at the Medical Student research day in November of 2021 and would have the opportunity to submit to state or regional OB/GYN conferences and present at OB/GYN department research days. Deadlines for submission to the ACOG conference are in early October, so projects completed over the summer or early during the school year are perfect for submission to this conference.	Student would need to feel comfortable calling patients on the phone to discuss the project (a script will be provided) and also entering data from Epic (and forms) into REDCap. If in person contact is permitted, student would need to be comfortable contacting patients in person	General familiarity with Epic and REDCap.	The IRB is approved and the project is ready to start once we have someone to work on this. We are currently working on the modification to allow remote contact to obtain names and email addresses.	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/)	PubMed Author Name: Antony KM	Yes	Kyndahl Lawrence ktlawrence@wisc.edu	Assessment of in-hospital pain control after delivery and its correlation with anxiety in the immediate and long-term postpartum period: While postpartum depression has become increasingly screened for, postpartum anxiety has not been as widely studied, despite a higher estimated incidence between 24.9-28.9%. Further characterization is needed about maternal perspectives on pain control postpartum with the implications that inadequate control has on emotional recovery, physical recovery, and maternal mental health. The aim of this study is to identify the role of post-delivery pain control in the development of postpartum anxiety by using surveys that are specific to the postpartum period. The survey at time of discharge will include a modification of the GAD-7 questionnaire and American Pain Society Patient Outcome Questionnaire (APSPOQ) while the survey at 6 weeks will be the GAD-7. ____________________________________________________________________________ Role - The student’s roles here will include 1. Approaching women admitted to the postpartum floor and requesting permission from the women (via signature and email address being recorded on a form) to have a survey emailed to them about anxiety (or alternatively, assuming COVID restrictions remain in place, calling the patient’s nurse and inquiring about whether the patient is willing to receive a call in her hospital room to discuss the project and then calling the patient in her hospital room and obtaining the patient’s name and email address via phone. A second alternative is having the resident physicians obtain permission to contact with an email address and phone number and having the student retrieve these forms) 2. Entering the email address into REDCap to send the questionnaire (the follow-up questionnaire will automatically send 6 weeks later), and 3. Entering clinical data about the postpartum women into the REDCap database. Of note, the consent is contained within the first page of the questionnaire as an “agree to proceed” or not which either prompts the questionnaire or a closing of questionnaire, respectively. During the summer Shapiro rotation, discharge survey data would become available and would be able to be analyzed during the summer for submission to a national OB/GYN meeting with an October deadline. The student would have the opportunity to be the first author on an abstract submitted to a national OB/GYN meeting (ACOG) and could present the poster there in April or May of 2022. The student would also have the opportunity to be first author on the manuscript of discharge survey data and, if desired, the 6 week postpartum survey data. The student would also be expected to present findings at the Medical Student research day in November of 2021 and would have the opportunity to submit to state or regional OB/GYN conferences and present at OB/GYN department research days. Deadlines for submission to the ACOG conference are in early October, so projects completed over the summer or early during the school year are perfect for submission to this conference. ; IRB Status - The IRB is approved and the project is ready to start once we have someone to work on this. We are currently working on the modification to allow remote contact to obtain names and email addresses. ; Skills - General familiarity with Epic and REDCap.	Kathleen Antony, kantony@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudXRZjbHXJQ7Wvtz1T7GP4VAPrr7IonJJ0Rlu7zU_F8rzOqbzRtlsmRtgU_y6xCGlA
07/01/2021	baweaver@wisc.edu	Beth	Weaver	PhD	Associate Professor	6.082.635.309	Cell and Regenerative Biology		Oncology		Pippa Cosper, MD, PhD	cosper@wisc.edu	Human Oncology		CIN as a biomarker of radiation sensitivity	Our overall goal is to determine whether chromosomal instability (CIN) sensitizes cervical and head and neck cancers (HNC) to radiation therapy and can be used as a predictive biomarker of treatment response. Definitive (chemo)radiation is the standard of care for these patients, though individual patient responses vary widely. Despite improvements in technology, there has been little progress in predicting radiosensitivity of tumors and all patients continue to be treated similarly without consideration of individual tumor biology. This results in a substantial portion of tumors, ~40% of locally advanced HNC, that incompletely respond or recur (1). At the other end of the spectrum, patients whose tumors completely respond often suffer treatment related morbidity, which could be reduced by dose de-escalation if a validated method was available to identify these treatment-sensitive tumors. Here we will test the innovative hypothesis, which is based on extensive preclinical and translational evidence, that measurement of CIN using a 6-chromosome FISH assay we have developed can allow prediction of which patients will benefit from dose de-escalation and which patients will benefit from inclusion of additional therapy. CIN, the recurrent missegregation of one or more chromosomes during multiple cell divisions, results in aneuploidy, an abnormal chromosome content. Aneuploidy is common in cancer, which led to the hypothesis that aneuploidy promotes tumorigenesis (2-5). However, our laboratory and others have discovered that aneuploidy can promote tumors, suppress them, or do neither, depending on the degree of CIN: low rates of CIN weakly promote tumors, while high rates of CIN cause cell death and suppress tumors. Importantly, combining two insults that each cause low CIN results in high CIN, cell death, and tumor suppression. We recently discovered that the taxane paclitaxel induces CIN in primary breast cancers, supporting a model in which paclitaxel exerts its efficacy by increasing the rate of CIN over a maximally tolerated threshold. Radiation also increases CIN, suggesting that tumors that exhibit inherent low CIN prior to treatment are preferentially sensitive to the CIN induced by radiation. By contrast, tumors that initially lack CIN may be more resistant to radiation since it only raises CIN to a low, tolerable level. These cancers could benefit from additional treatments that independently increase CIN, such as paclitaxel or its analog docetaxel. Consistent with this hypothesis, our preliminary data in cervical and HNC cell lines and HNC patient derived xenograft (PDX) tumors reveal that pre-treatment CIN sensitizes cancers to radiation and could be used as a predictive marker for radiation response. Weaver lab website: https://weaver.crb.wisc.edu/	1	chart review to identify patients treated with definitive chemoradiation; microscopic analysis of CIN	After training, the student is expected to work independently, in consultation with mentors	Training will be provided.	approved	Yes	No (plan to use Dean's Office Funds)	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	PhD students	Zasadil, L.M., Andersen, K., Ryan, S.D., Yeum, D., Raines, R., Burkard, M.E., and Weaver, B.A. 2014. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Science Transl Med 6:229ra43. Zasadil L.M., Britigan E.M.C., Ryan S.D., Kaur C., Guckenberger D.J., Beebe, D.J., Moser A.R., Weaver B.A. 2016. High rates of chromosome missegregation suppress tumor progression, but do not inhibit tumor initiation. Mol Biol Cell 27: 1981-9. Burkard M.E. and Weaver B.A. 2017. Tuning chromosomal instability to optimize tumor fitness. Cancer Discov 7: 134-136. Funk, L.C., Wan, J., Ryan, S.D., Kaur, C., Sullivan, R., Roopra, A., and Weaver, B.A. 2020. p53 is not required for high CIN to induce tumor suppression. Molecular Cancer Research. doi: 10.1158/1541-7786.MCR-20-0488. Scribano et al, Chromosomal instability sensitizes tumors to multipolar divisions induced by paclitaxel, in revision.	Yes	N/A	CIN as a biomarker of radiation sensitivity: Our overall goal is to determine whether chromosomal instability (CIN) sensitizes cervical and head and neck cancers (HNC) to radiation therapy and can be used as a predictive biomarker of treatment response. Definitive (chemo)radiation is the standard of care for these patients, though individual patient responses vary widely. Despite improvements in technology, there has been little progress in predicting radiosensitivity of tumors and all patients continue to be treated similarly without consideration of individual tumor biology. This results in a substantial portion of tumors, ~40% of locally advanced HNC, that incompletely respond or recur (1). At the other end of the spectrum, patients whose tumors completely respond often suffer treatment related morbidity, which could be reduced by dose de-escalation if a validated method was available to identify these treatment-sensitive tumors. Here we will test the innovative hypothesis, which is based on extensive preclinical and translational evidence, that measurement of CIN using a 6-chromosome FISH assay we have developed can allow prediction of which patients will benefit from dose de-escalation and which patients will benefit from inclusion of additional therapy. CIN, the recurrent missegregation of one or more chromosomes during multiple cell divisions, results in aneuploidy, an abnormal chromosome content. Aneuploidy is common in cancer, which led to the hypothesis that aneuploidy promotes tumorigenesis (2-5). However, our laboratory and others have discovered that aneuploidy can promote tumors, suppress them, or do neither, depending on the degree of CIN: low rates of CIN weakly promote tumors, while high rates of CIN cause cell death and suppress tumors. Importantly, combining two insults that each cause low CIN results in high CIN, cell death, and tumor suppression. We recently discovered that the taxane paclitaxel induces CIN in primary breast cancers, supporting a model in which paclitaxel exerts its efficacy by increasing the rate of CIN over a maximally tolerated threshold. Radiation also increases CIN, suggesting that tumors that exhibit inherent low CIN prior to treatment are preferentially sensitive to the CIN induced by radiation. By contrast, tumors that initially lack CIN may be more resistant to radiation since it only raises CIN to a low, tolerable level. These cancers could benefit from additional treatments that independently increase CIN, such as paclitaxel or its analog docetaxel. Consistent with this hypothesis, our preliminary data in cervical and HNC cell lines and HNC patient derived xenograft (PDX) tumors reveal that pre-treatment CIN sensitizes cancers to radiation and could be used as a predictive marker for radiation response. Weaver lab website: https://weaver.crb.wisc.edu/ ____________________________________________________________________________ Role - chart review to identify patients treated with definitive chemoradiation; microscopic analysis of CIN; IRB Status - approved; Skills - Training will be provided.	Beth Weaver, baweaver@wisc.edu -- Co-Mentor: Pippa Cosper, MD, PhD cosper@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucttSnjYogTNQQHpd7d5MquNJVELa08RIRwOEVYXm42ePEOJKOam69E0J3YBbCwyFY
08/01/2021	lmaursetter@medicine.wisc.edu	Laura	Maursetter	DO	Associate Professor	608	Medicine	Nephrology	Medicine	Internal Medicine					Education Research: Qualitative analysis of Student and Resident Goal setting for clinical rotations	For the nephrology rotation, we have been asking each resident and medical student to create a goal for medical knowledge, behavior, wellness, for the last 3 years. In this project, we hope to analyze these goals to determine the areas of focus, the specificity of these goals and finally if these goals were addressed during their rotation.	0	Assist in the design, perform the analysis and the writing of the manuscript.	Significant Independence	Enthusiasm to learn qualitative analysis, writing skills for the mauscript	Will be submitted in January	No	Department of medicine support if possible.	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	UW undergraduates interested in research	NA	Yes	Betty Weiss	Education Research: Qualitative analysis of Student and Resident Goal setting for clinical rotations: For the nephrology rotation, we have been asking each resident and medical student to create a goal for medical knowledge, behavior, wellness, for the last 3 years. In this project, we hope to analyze these goals to determine the areas of focus, the specificity of these goals and finally if these goals were addressed during their rotation. ____________________________________________________________________________ Role - Assist in the design, perform the analysis and the writing of the manuscript.; IRB Status - Will be submitted in January; Skills - Enthusiasm to learn qualitative analysis, writing skills for the mauscript	Laura Maursetter, lmaursetter@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucF1q1CdsE9v_AFovUjF2Y3C6Sn_pwuPTx4YX28IDTuqY0h9xphazm9MBY3fmcI9FY
08/01/2021	bikashp@pediatrics.wisc.edu	Bikash	Pattnaik	PhD	Assistant Professor and Clinical Director	6.082.659.486	Pediatrics	Neonatology	Ophthalmology and Visual Sciences	Clinical Electrophysiology	Pelin Cengiz	pcengiz@pediatrics.wisc.edu	Pediatrics	Critical Care	Visual function and new device as diagnostic tool for	We have several projects that can be supported by summer Medical Student Interns. 1) Neonatal hypoxic-ischemic encephalopathy (HIE) is a common cause of brain injury in newborns affecting 3-5 in 1000 live births, which equate to approximately 20,000 newborns per year in the US. HIE's diagnosis can be challenging at birth, especially if the neonate has very subtle neurological injury signs. Thus, infants with missed or delayed diagnosis of HIE present with neurological deficits later in life. Therefore, innovative diagnostic techniques are necessary to help providers with crucial information on the HIE outcome. Early diagnosing HIE will promote immediate clinical interventions to improve neurodevelopmental outcomes. Emerging data obtained from experimental and clinical studies have recently shown that visual injury (ocular motor dysfunction, nystagmus, dilated pupils, and poor light reactivity) is common in HIE survivors and might be contributing to neurodevelopmental delays. However, the diagnostic and prognostic utility of HIE-related visual injury is unknown. To better characterize the findings of visual injury due to HIE, we propose to conduct a longitudinal study utilizing a handheld portable device to perform electroretinogram (ERG) and visual evoked potential (VEP). We hypothesize that the ERG and VEP results obtained at birth will correlate with 1) neurological exam at birth, 2) imaging (mainly MRI) outcomes, and 3) neurodevelopmental outcomes. In summary, this study aims to use the ERG and VEP (visual function) data to help us diagnose HIE early after birth and predict neurodevelopmental or neuroimaging outcomes. 2) In clinical ophthalmology, visual electrophysiology provides a non-invasive objective assessment of visual function. Trained electrophysiologists generally perform these tests in a clinical setting with test equipment and a light tight room devoid of extraneous electrical noise. At UW-Madison, we also use electrophysiological tests in the OR under general anesthesia in pediatric patients who are young to understand and challenging to perform these tests in the clinic. Tests are also performed in conjunction with other OR procedures. For the test, a dark adaptation is made under anesthesia followed by dark-adapted and light-adapted responses, with a total time of about 90 minutes. To circumvent this, we plan to design dark room stimulator goggles (DRSG) based on standard virtual reality wearable goggles that would have a separation along the nasal line for exposing each eye independently. The design also involves installation of CMOS sensors and LED light layout. Besides avoiding OR downtime, the visual function test could aid in intraoperative tracking for other surgeries.	2	You will be involved in the study design and perform data acquisition and analysis.	Should be able to perform tasks independently with guidance.	Neuroscience or BME interests are positives.	IRB Approved	UW-SMPH and Department	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	Genetic Counseling students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Robson, A.G., et al., ISCEV guide to visual electrodiagnostic procedures. Doc Ophthalmol, 2018. 136(1): p. 1-26. Hansen, R.M. and A.B. Fulton, Development of the cone ERG in infants. Invest Ophthalmol Vis Sci, 2005. 46(9): p. 3458-62. Odom, J.V., et al., ISCEV standard for clinical visual evoked potentials: (2016 update). Doc Ophthalmol, 2016. 133(1): p. 1-9. Lenassi, E., et al., VEP maturation and visual acuity in infants and preschool children. Doc Ophthalmol, 2008. 117(2): p. 111-20. Muttitt, S.C., et al., Serial visual evoked potentials and outcome in term birth asphyxia. Pediatr Neurol, 1991. 7(2): p. 86-90. McCulloch, D.L., M.J. Taylor, and H.E. Whyte, Visual evoked potentials and visual prognosis following perinatal asphyxia. Arch Ophthalmol, 1991. 109(2): p. 229-33. Huo, R., et al., Chronic cortical visual impairment in children: aetiology, prognosis, and associated neurological deficits. Br J Ophthalmol, 1999. 83(6): p. 670-5. Hoyt, C.S., Brain injury and the eye. Eye (Lond), 2007. 21(10): p. 1285-9. Hoyt, C., Visual function in the brain-damaged child. Eye, 2003. 17(3): p. 369.	Yes	N/A	Visual function and new device as diagnostic tool for : We have several projects that can be supported by summer Medical Student Interns. 1) Neonatal hypoxic-ischemic encephalopathy (HIE) is a common cause of brain injury in newborns affecting 3-5 in 1000 live births, which equate to approximately 20,000 newborns per year in the US. HIE's diagnosis can be challenging at birth, especially if the neonate has very subtle neurological injury signs. Thus, infants with missed or delayed diagnosis of HIE present with neurological deficits later in life. Therefore, innovative diagnostic techniques are necessary to help providers with crucial information on the HIE outcome. Early diagnosing HIE will promote immediate clinical interventions to improve neurodevelopmental outcomes. Emerging data obtained from experimental and clinical studies have recently shown that visual injury (ocular motor dysfunction, nystagmus, dilated pupils, and poor light reactivity) is common in HIE survivors and might be contributing to neurodevelopmental delays. However, the diagnostic and prognostic utility of HIE-related visual injury is unknown. To better characterize the findings of visual injury due to HIE, we propose to conduct a longitudinal study utilizing a handheld portable device to perform electroretinogram (ERG) and visual evoked potential (VEP). We hypothesize that the ERG and VEP results obtained at birth will correlate with 1) neurological exam at birth, 2) imaging (mainly MRI) outcomes, and 3) neurodevelopmental outcomes. In summary, this study aims to use the ERG and VEP (visual function) data to help us diagnose HIE early after birth and predict neurodevelopmental or neuroimaging outcomes. 2) In clinical ophthalmology, visual electrophysiology provides a non-invasive objective assessment of visual function. Trained electrophysiologists generally perform these tests in a clinical setting with test equipment and a light tight room devoid of extraneous electrical noise. At UW-Madison, we also use electrophysiological tests in the OR under general anesthesia in pediatric patients who are young to understand and challenging to perform these tests in the clinic. Tests are also performed in conjunction with other OR procedures. For the test, a dark adaptation is made under anesthesia followed by dark-adapted and light-adapted responses, with a total time of about 90 minutes. To circumvent this, we plan to design dark room stimulator goggles (DRSG) based on standard virtual reality wearable goggles that would have a separation along the nasal line for exposing each eye independently. The design also involves installation of CMOS sensors and LED light layout. Besides avoiding OR downtime, the visual function test could aid in intraoperative tracking for other surgeries. ____________________________________________________________________________ Role - You will be involved in the study design and perform data acquisition and analysis. ; IRB Status - IRB Approved; Skills - Neuroscience or BME interests are positives.	Bikash Pattnaik, bikashp@pediatrics.wisc.edu -- Co-Mentor: Pelin Cengiz pcengiz@pediatrics.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufdhIzONBblrlaB2pBwCVwyC9sUkjQM3MrfHZVQxd68KNJKKZhijpruAB4dl3CP56A
10/01/2021	kmschro1@wisc.edu	Kristopher	Schroeder	MD	Professor	6.082.321.542	Anesthesiology	Regional Anesthesia and Acute Pain Medicine							Assessing how Impact Factor Changes the Relationship Between Quantitative & Qualitative reporting in Academic Literature	The overall goal in this study is to assess the relationship between the quantitative findings reported in clinical trial literature to how the authors present this information in written format, as well as the effect of the publishing journal’s impact factor on this relationship. Assessing this relationship is a step to better define the impact of publication bias in medical literature as disparities or changes in this relationship may be indicative of biased reporting which has the potential to impact appropriate provision of evidence-based medicine. The quantitative measurements in this study will be developed using a method of natural language process called sentiment analysis that can translate text into quantitative sentiment scores that can be compared to other numerical values such as reported p-values and journal impact factors in a consistent manner. In addition to the research project, the student will also have opportunities to shadow within the anesthesia department according to their interest level.	0	The student will lead the project, including the necessary data gathering, analysis, and written reporting of the results.	The student will work independently to collect and evaluate data. Faculty will work with student on concept development and evaluation.	Experience interpreting academic literature, Background in coding & machine learning techniques.	N/A	No	Yes	Yes	Shorter term projects, Research Electives for credit	RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Assessing Sentiment Analysis as a Method to Analyse Reporting Bias in Regional Anesthesiology Literature - manuscript in preparation	Yes	Mary Roth maroth4@wisc.edu, Judy Helt jhelt@wisc.edu	Assessing how Impact Factor Changes the Relationship Between Quantitative & Qualitative reporting in Academic Literature: The overall goal in this study is to assess the relationship between the quantitative findings reported in clinical trial literature to how the authors present this information in written format, as well as the effect of the publishing journal’s impact factor on this relationship. Assessing this relationship is a step to better define the impact of publication bias in medical literature as disparities or changes in this relationship may be indicative of biased reporting which has the potential to impact appropriate provision of evidence-based medicine. The quantitative measurements in this study will be developed using a method of natural language process called sentiment analysis that can translate text into quantitative sentiment scores that can be compared to other numerical values such as reported p-values and journal impact factors in a consistent manner. In addition to the research project, the student will also have opportunities to shadow within the anesthesia department according to their interest level. ____________________________________________________________________________ Role - The student will lead the project, including the necessary data gathering, analysis, and written reporting of the results.; IRB Status - N/A; Skills - Experience interpreting academic literature, Background in coding & machine learning techniques.	Kristopher Schroeder, kmschro1@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucB2LcE_80hjtRt14s5-zHaZbW5Vfio77t--FaLFKTz17mT7xXxFqJivPU2p-oJB3k
10/01/2021	cseibert@wisc.edu	Christie	Seibert	MD	Associate Dean for Medical Education and Services	1	Medicine	General Internal Medicine	Academic Affairs		Tracy Downs	downs@urology.wisc.edu	Urology		Assessment and Planning for a More Inclusive and Antiracist HSLC Physical Space	When striving to become more anti-racist institution, it is important to assess and address the physical spaces where community members work, learn, study and relax. The White Coat 4 Black Lives (WCFBL) report card states that “physical space is one of the important elements of anti-racist institutions” and that medical schools should acknowledge the contributions of alumni and other physicians of color (through plaques, statues, portraits, and building names) while not celebrating racist or white supremacist individuals. Furthermore, medical schools must ensure that alumni of color, as well as patients and other people of color who have contributed to the advancement of medical science, are celebrated publicly. We will sponsor a student to perform an assessment of the SMPH HSLC physical spaces to determine who is currently highlighted/celebrated, researching the backgrounds of those individuals as well as seek out (with the assistance/expertise of Micaela Sullivan-Fowler--Ebling Historian/Librarian) images and stories of physicians of color that could be added to those that are recognized and celebrated in our spaces.	0	Student will have the unique opportunity to perform an assessment of the SMPH HSLC physical spaces to determine the representation of those who are highlighted/celebrated, researching the backgrounds of those individuals as well as seek out (with the assistance/expertise of Michaela Sullivan-Fowler--Ebling Historian/Librarian) images and stories of physicians of color that could be added to those that are recognized and celebrated in our spaces.	Needs to be a self-starter, able to work on and move a project forward with minimal supervision.	Organizational skills, database creation to catalog findings	NA	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	NA	Yes	Elizabeth Tuschen, Academic Affairs/Medical Education Departmental Administrator	Assessment and Planning for a More Inclusive and Antiracist HSLC Physical Space: When striving to become more anti-racist institution, it is important to assess and address the physical spaces where community members work, learn, study and relax. The White Coat 4 Black Lives (WCFBL) report card states that “physical space is one of the important elements of anti-racist institutions” and that medical schools should acknowledge the contributions of alumni and other physicians of color (through plaques, statues, portraits, and building names) while not celebrating racist or white supremacist individuals. Furthermore, medical schools must ensure that alumni of color, as well as patients and other people of color who have contributed to the advancement of medical science, are celebrated publicly. We will sponsor a student to perform an assessment of the SMPH HSLC physical spaces to determine who is currently highlighted/celebrated, researching the backgrounds of those individuals as well as seek out (with the assistance/expertise of Micaela Sullivan-Fowler--Ebling Historian/Librarian) images and stories of physicians of color that could be added to those that are recognized and celebrated in our spaces. ____________________________________________________________________________ Role - Student will have the unique opportunity to perform an assessment of the SMPH HSLC physical spaces to determine the representation of those who are highlighted/celebrated, researching the backgrounds of those individuals as well as seek out (with the assistance/expertise of Michaela Sullivan-Fowler--Ebling Historian/Librarian) images and stories of physicians of color that could be added to those that are recognized and celebrated in our spaces. ; IRB Status - NA; Skills - Organizational skills, database creation to catalog findings	Christie Seibert, cseibert@wisc.edu -- Co-Mentor: Tracy Downs downs@urology.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudeEvZLIZ2eDUoqvlBPhp7yw7lN6PAbKUwWBETuHRRvbbfok8XC1PAUUrd_8jfOsFg
11/01/2021	kims@surgery.wisc.edu	Steven	Kim	MD	Transplant Surgery Fellow		Surgery	Transplant			Dixon Kaufman		Surgery	Transplant	Tolerance NHP Project	we are investigating how costimulation blockade may improve engraftment of stem cells in an effort towards reaching tolerance for transplant recipients.	0	Student interested in basic or translational research experience. Will discuss in further detail while meeting.		Will Discuss	Pending	Yes	Yes	Yes	Will discuss timeline at meeting	Not currently available to mentor other students	Will discuss in additional detail	No	Sarah Pavao	Tolerance NHP Project: we are investigating how costimulation blockade may improve engraftment of stem cells in an effort towards reaching tolerance for transplant recipients. ____________________________________________________________________________ Role - Student interested in basic or translational research experience. Will discuss in further detail while meeting.; IRB Status - Pending; Skills - Will Discuss	Steven Kim, kims@surgery.wisc.edu -- Co-Mentor: Dixon Kaufman	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud5RL5Ctu9mYSYHZji45LmPamaxx40uqHnLQP2wOIVmu51TxH9TelHEQejp8qOmj3c
11/01/2021	cakelm@wisc.edu	Cynthia	Kelm-Nelson	PhD	Associate Scientist		Surgery	Otolaryngology Head and Neck Surgery							Vocal Communication Deficits in Parkinson's Disease	There are a number of projects available in my lab. Happy to discuss options and opportunities	1	Basic science lab - happy to discuss options based upon project interest.		TBD	Pending	Yes	Yes	Yes	TBD	PhD students, UW undergraduates interested in research	TBD	Yes	Sarah Pavao	Vocal Communication Deficits in Parkinson's Disease: There are a number of projects available in my lab. Happy to discuss options and opportunities ____________________________________________________________________________ Role - Basic science lab - happy to discuss options based upon project interest.; IRB Status - Pending; Skills - TBD	Cynthia Kelm-Nelson, cakelm@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufu3KS8S6H5eRazl80DXcgtqSH-EYzp9t2018sJ-MXrFYwGp_9mSLraM_KROWbv40U
11/01/2021	godbout@surgery.wisc.edu	Rachel	Godbout	MS	Clinical Research Database Assistant		Surgery	Otolaryngology			Susan Thibeault, PhD		Surgery	Otolaryngology	Voice and Swallow Outcomes Database	The purpose of the Voice and Swallow Outcomes Database is to use de-identified, previously collected data from both adult and pediatric subjects to answer research questions concerning the diagnosis, evaluation, and medical and/or surgical treatment of voice, swallow, and breathing/cough concerns. Adult and pediatric patients who consented on or after 1/30/2009 as well as retrospective patients are eligible for inclusion in the Voice and Swallow Outcomes Database. These patients were initially evaluated by a speech language pathologist (SLP) and/or otolaryngologist due to voice, swallow, or breathing/cough concerns. Since the database’s inception in 2009 under Principal Investigator Dr. Susan Thibeault, we have added 550 adult patients per year and 50 pediatric patients per year. The database banks consented adult and pediatric subjects’ evaluation and treatment data regarding stroboscopy, acoustics, VFSS, FEES, manometry, therapy, surgeries such laryngectomies and thyroidectomies, and procedures such as Botox injections, thyroplasties, and biopsies. Besides evaluation and treatment data, a wide array of supporting data is inputted, including patients’ intake form answers, medical and surgical history, previous work-ups like allergy or reflux testing, smoking history, referring providers, etc. Additionally, longitudinal outcomes data is collected from adult patients from self-administered, validated quality of life assessments at 3, 6, and 12 months after each treatment.	1	To discuss	To Discuss	To discuss	In Place	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	PhD students	To Discuss	Yes	Sarah Pavao	Voice and Swallow Outcomes Database: The purpose of the Voice and Swallow Outcomes Database is to use de-identified, previously collected data from both adult and pediatric subjects to answer research questions concerning the diagnosis, evaluation, and medical and/or surgical treatment of voice, swallow, and breathing/cough concerns. Adult and pediatric patients who consented on or after 1/30/2009 as well as retrospective patients are eligible for inclusion in the Voice and Swallow Outcomes Database. These patients were initially evaluated by a speech language pathologist (SLP) and/or otolaryngologist due to voice, swallow, or breathing/cough concerns. Since the database’s inception in 2009 under Principal Investigator Dr. Susan Thibeault, we have added 550 adult patients per year and 50 pediatric patients per year. The database banks consented adult and pediatric subjects’ evaluation and treatment data regarding stroboscopy, acoustics, VFSS, FEES, manometry, therapy, surgeries such laryngectomies and thyroidectomies, and procedures such as Botox injections, thyroplasties, and biopsies. Besides evaluation and treatment data, a wide array of supporting data is inputted, including patients’ intake form answers, medical and surgical history, previous work-ups like allergy or reflux testing, smoking history, referring providers, etc. Additionally, longitudinal outcomes data is collected from adult patients from self-administered, validated quality of life assessments at 3, 6, and 12 months after each treatment. ____________________________________________________________________________ Role - To discuss; IRB Status - In Place; Skills - To discuss	Rachel Godbout, godbout@surgery.wisc.edu -- Co-Mentor: Susan Thibeault, PhD	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf8z8SmAAX5B4CsvmUOeTu1HQ0QW-9pRyfjjMhJkZC-mC84oA36TyFCd_mKZsGe2EA
11/01/2021	tsenkova@wisc.edu	Vera	Tsenkova	PhD	Director of Student Research at SMPH		Academic Affairs								Student Research Outcomes	Our summer research program has grown significantly since its inception. The goal of our project is to describe the growth in student research experiences and explore whether students of all backgrounds have been represented among the summer scholars and among those graduating with research distinctions. Students will work closely with faculty and staff in Academic Affairs and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Student’s primary responsibility will include conducting a literature review, helping with data coding, and writing sections of the manuscript.	1	depends on student interests and skills		enthusiasm	N/A	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	none	Yes	none	Student Research Outcomes: Our summer research program has grown significantly since its inception. The goal of our project is to describe the growth in student research experiences and explore whether students of all backgrounds have been represented among the summer scholars and among those graduating with research distinctions. Students will work closely with faculty and staff in Academic Affairs and will gain knowledge and skills that are relevant to careers in academic medicine leadership. It is expected that work done by students will lead to opportunities for presentations and publications. Student’s primary responsibility will include conducting a literature review, helping with data coding, and writing sections of the manuscript. ____________________________________________________________________________ Role - depends on student interests and skills; IRB Status - N/A; Skills - enthusiasm	Vera Tsenkova, tsenkova@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucH5E2VX_cBi946RX1LDF7wpXPSE8ty_JOuSDQCE-uEvrEYQur1bMyGBQkpE_8HufA
12/01/2021	spiker@ortho.wisc.edu	Andrea	Spiker	M.D.	Assistant Professor, Orthopedic Surgery	6.082.346.716	Orthopedics and Rehabilitation	Sports Medicine							The prevalence of MRI identified abductor and proximal hamstring tendon pathology in hip arthroscopy patients	We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who have undergone hip arthroscopy for femoroacetabular impingement (FAI). We are evaluating the prevalence of extra-articular pathology, as identified on pre-operative MRI of the operative hip, specifically related to the abductor and proximal hamstring tendons. We will exclude any patients who have symptoms consistent with pathology in these areas, focusing on those patients who have asymptomatic MRI diagnosed tendinosis. The patients with positive MRI findings of abductor and proximal hamstring pathology will be compared to those patients with negative MRI findings at the abductors and proximal hamstrings. The groups will be compared based on patient reported outcome measures, clinical exam findings, and radiographic measurements. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine) to have a more complete understanding of the importance of this study.	0	A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the Hip Preservation Registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects.	Moderate - We will give specific instructions and direction, but the student will need to be self-motivated to complete the project and make the most out of the experience.	Excel and Word. Organizational skills and good communication with the other members of the team.	Pending	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	This would be a stand-alone project, so no related publications exist. The idea would be for the student to complete and be a published author on this project.	Yes	Heidi Ableidinger (Ableidinger@ortho.wisc.edu) Orthopedics Student Services Coordinator; Katie Schjei (Schjei@ortho.wisc.edu) Hip Preservation Research Coordinator	The prevalence of MRI identified abductor and proximal hamstring tendon pathology in hip arthroscopy patients: We would like to involve a summer research student in the continued growth of our IRB-approved patient reported outcome (PRO) Hip Preservation Registry at the University of Wisconsin and in a research study utilizing the data collected in this registry. This project will provide the student with the opportunity to learn about the basics of developing a registry, collaborating with statisticians, clinicians, research professionals, residents in training, and allows him or her to participate in the writing of the project manuscript and submission of the final project, as well as in the preparation and presentation of posters and/or podiums if/when they are accepted to local, national and/or international conferences. Our specific project involves a retrospective review of patients who have undergone hip arthroscopy for femoroacetabular impingement (FAI). We are evaluating the prevalence of extra-articular pathology, as identified on pre-operative MRI of the operative hip, specifically related to the abductor and proximal hamstring tendons. We will exclude any patients who have symptoms consistent with pathology in these areas, focusing on those patients who have asymptomatic MRI diagnosed tendinosis. The patients with positive MRI findings of abductor and proximal hamstring pathology will be compared to those patients with negative MRI findings at the abductors and proximal hamstrings. The groups will be compared based on patient reported outcome measures, clinical exam findings, and radiographic measurements. I would welcome the student to shadow in my orthopaedic clinic and operating rooms (as much or as little as desired) if he or she would be interested in gaining a clinical and operative experience. As part of this specific project, the student would be highly encouraged to observe clinic and operative cases involving the patient group we are studying (sports medicine) to have a more complete understanding of the importance of this study. ____________________________________________________________________________ Role - A limited portion of the student’s time (approximately one day/week) would be dedicated to entering patient data into the Hip Preservation Registry. Specific tasks related to the project detailed above include maintaining the patient list and measures obtained, and being a direct liaison between the attending surgeon and physician, athletic trainers, orthopedic surgery resident, Hip Preservation research coordinator and statisticians involved in this project. The student will be paired with a resident and work with a research coordinator who can assist him/her in the project as well as abstract and manuscript preparation. Additionally, the student will attend weekly check-in meetings with the surgeon PI to discuss progress of the research as well as to follow a summer research curriculum created by the PI. This curriculum is geared at introducing the student to clinical research and how to complete research projects. ; IRB Status - Pending; Skills - Excel and Word. Organizational skills and good communication with the other members of the team.	Andrea Spiker, spiker@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudXWStPoMc9nUZkghCrb_9yZIeDU4_i-XzNGRAHMzCKm-bfKzUScXBXDvjrthULij8
12/01/2021	szafar2@wisc.edu	S. Nabeel	Zafar	MD MPH	Assistant Professor of Surgery	4.104.467.225	Surgery	Surgical Oncology							Outcomes after Cancer Surgery in Low-and-Middle Income Countries	This will be a systematic review and meta-analysis of mortality and morbidity following different types of cancer surgery in low-and-middle income countries (LMICs).Cancer is soon to be the #1 leading cause of death around the world. Surgery plays an essential role in its management with about 80% of patient with cancer requiring some sort of surgery. Less developed countries (LMICs) bear the brunt of this burden. This project will provide valuable baseline information on the outcomes of patients undergoing surgery for cancers in LMICs.	0	The student will work closely with the faculty supervisor and a research resident. The larger team will consist of other international medical students with many opportunities for interactions. The students will be assist in reviewing titles and abstracts for inclusion in the study, reading full text articles and extracting data from them. The student will participate in analysis and interpretation of data, manuscript writing and presentation. This project can be completed in a 6-8 week period of time. The students will be mentored on the design and conduct of a systematic review and meta-analysis. These skills are valuable are versatile. The student can apply these skills in any area of medicine at any point in their career.	The student will be mentored throughout this project. No specific degree of independence is required other than what every medical student already possess.	No prior research experience is required. A general knowledge of literature search is helpful. The student will be mentored and we will work with the current level of skill and background and build on it.	Not applicable	startup funds	Department covers it	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	The quality and outcomes after cancer surgery - a global study (manuscript in process - Lancet) The Lancet Oncology Commission on Global Cancer Surgery part II (manuscript in preparation) Estimating the Global Demand and Delivery of Cancer Surgery. World J Surg. 2019 Sep;43(9):2203-2210. Delaying surgery for patients with a previous SARS-CoV-2 infection. Br J Surg. 2020 Nov;107(12):e601-e602. Predicting Risk of Recurrence After Colorectal Cancer Surgery in the United States: An Analysis of a Special Commission on Cancer National Study. Ann Surg Oncol. 2020 Aug;27(8):2740-2749 Complete list of publication at https://www.ncbi.nlm.nih.gov/sites/myncbi/1XE1iZ24marAf/bibliography/44171947/public/?sort=date&direction%20=descending	Yes	Michaela Gombar (gombar@surgery.wisc.edu)	Outcomes after Cancer Surgery in Low-and-Middle Income Countries: This will be a systematic review and meta-analysis of mortality and morbidity following different types of cancer surgery in low-and-middle income countries (LMICs).Cancer is soon to be the #1 leading cause of death around the world. Surgery plays an essential role in its management with about 80% of patient with cancer requiring some sort of surgery. Less developed countries (LMICs) bear the brunt of this burden. This project will provide valuable baseline information on the outcomes of patients undergoing surgery for cancers in LMICs. ____________________________________________________________________________ Role - The student will work closely with the faculty supervisor and a research resident. The larger team will consist of other international medical students with many opportunities for interactions. The students will be assist in reviewing titles and abstracts for inclusion in the study, reading full text articles and extracting data from them. The student will participate in analysis and interpretation of data, manuscript writing and presentation. This project can be completed in a 6-8 week period of time. The students will be mentored on the design and conduct of a systematic review and meta-analysis. These skills are valuable are versatile. The student can apply these skills in any area of medicine at any point in their career.; IRB Status - Not applicable ; Skills - No prior research experience is required. A general knowledge of literature search is helpful. The student will be mentored and we will work with the current level of skill and background and build on it.	S. Nabeel Zafar, szafar2@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufQsF2GNaIeGj4CiaX4khv3O110ofE3RxGLAMaEDkqxuBR2nof9mB7LzbJ5SspBsq8
12/01/2021	dempsey@neurosurgery.wisc.edu	Robert	Dempsey	MD	Professor and Chair	6.082.655.967	Neurological Surgery				Uma Wesley PhD	wesley@neurosurgery.wisc.edu	Neurological Surgery		Shapiro Summer Research Program - 2021	The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke.	0	Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field.	Fairly independent	Some exposure to basic lab technique. However, we will train. train	approved	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	see lab webpage	Yes	wesley@neurosurgery.wisc.edu	Shapiro Summer Research Program - 2021: The Dempsey lab currently has multiple, but related research projects with focus on cerebral ischemia and brain injury, and tumor stem cell driven glioblastoma. Dr. Dempsey has lead a group of neurosurgeons and scientists dedicated to neurosurgical patient care. Our research focus includes; • The biochemistry of ischemic stroke brain edema and brain injury; Lipid changes and other factors in the formation of carotid artery atherosclerosis; The modification of adult progenitor/stem cells in brain after focal cerebral ischemia; Acute management of subarachnoid hemorrhage; Applied research in stroke, brain perfusion, subarachnoid hemorrhage and trauma; • The molecular and cellular Biology of post-stroke brain and embolic carotid diseases, atherosclerosis and its relationship to functional our come and cognitive impairment. • The other goals of our research include identification of the therapeutic targets, and elucidate the underlying mechanisms of tumor cell and stem cell survival, migration, and angiogenesis. We are particularly interested in the role of inflammation, proteases, and cytokines in regulating these physiological events that drive the development and progression of glioblastoma (GBM), a cancer of central nervous system. The soluble growth factors, cytokines, and extracellular matrix components in the microenvironment contribute significantly to the stem cell dynamics, development of neuronal tumors, and brain injury repair following stroke. ____________________________________________________________________________ Role - Students are required to follow protocols and safety procedures approved for our lab. They are expected to learn and get involved in the experimental procedures, lab maintenance, and maintain proper etiquette. They are expected to contribute to ongoing projects. Dr. Wesley will be the primary supervisor in lab. They will meet with Dr. Dempsey and the entire lab team during our biweekly lab meeting to discuss the progress of the project. They can also attend Neurological Surgery Grand Rounds and journal clubs several times throughout the summer to gain further knowledge of this field. ; IRB Status - approved; Skills - Some exposure to basic lab technique. However, we will train. train	Robert Dempsey, dempsey@neurosurgery.wisc.edu -- Co-Mentor: Uma Wesley PhD wesley@neurosurgery.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufvjdLgVPBKsh1tMPSyA6BKzfhinUE-2DDIyhRuzSpxsaPVHa-oQYeYvoAdJB6Hjdg
12/01/2021	zelenski@medicine.wisc.edu	Amy	Zelenski	PhD	Assistant Professor		Medicine		Surgery						Gender Differences in Employee Recognition Practices	We plan to evaluate whether a difference exists among men and women trainees in their experience of the UW Health employee recognition program (Hi 5).	1	The student will assist in coding the collected de-identified employee recognition entries from the departments of Surgery, Pediatrics, and Medicine. There are 3 other research team members who will assist with the coding and we will use group consensus for adjudication.		Attention to detail	Approved - Minimal Risk	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	Genetic Counseling students, PhD students, UW undergraduates interested in research	Zelenski AB, Tischendorf JS, Kessler M, et al. Beyond “Read More”: An Intervention to Improve Faculty Written Feedback to Learners. Journal of Graduate Medical Education. Published online June 28, 2019. doi:10.4300/JGME-D-19-00058.1	Yes	Sherie Renders, slr@medicine.wisc.edu	Gender Differences in Employee Recognition Practices: We plan to evaluate whether a difference exists among men and women trainees in their experience of the UW Health employee recognition program (Hi 5). ____________________________________________________________________________ Role - The student will assist in coding the collected de-identified employee recognition entries from the departments of Surgery, Pediatrics, and Medicine. There are 3 other research team members who will assist with the coding and we will use group consensus for adjudication. ; IRB Status - Approved - Minimal Risk; Skills - Attention to detail	Amy Zelenski, zelenski@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucJriY24ppohWIc331C28lg-evhe_C1DjuVVtYftXDAU3yZDk47ykhlsVHf4zovdb8
12/01/2021	cb4@medicine.wisc.edu	Christie	Bartels	MD MS	Associate Professor	6.082.633.457	Medicine	Rheumatology			Maria Schletzbaum	schletzbaum@wisc.edu	Medicine		Retention in Healthcare among Young Patients with Lupus	Systemic Lupus Erythematous (SLE) affects 1.5 million Americans and is three times more common in people of minority race and ethnicity, who are more likely to have pediatric-onset SLE (pSLE). Young adults with SLE are 20 times more likely to die prematurely vs. peers and twice as likely to develop kidney disease vs. adult-onset SLE, yet staying in care and on therapy for SLE may reduce such risks. The goal of this project is to identify patient and context factors that predict such retention in healthcare and on treatment for lupus among pediatric patients using previously collected data from the national Childhood Arthritis and Rheumatology Research Alliance Registry. In other diseases such as HIV, patients retained in care and on therapy over time has been measured, correlated with disease outcomes, and used to targets improving care and health outcomes. The Bartels Lab is applying this framework to the care of adult and pediatric SLE patients to understand and quantify health disparities gaps with the aim of developing interventions to reduce health disparities in lupus. Specifically, the role of the student researcher will be to conduct a literature review, create new data variables (e.g., distance of residence from rheumatology care), conduct data quality audits, create figures, and write text for a scientific abstract and manuscript. The student will learn interpretation of statistical outputs, and if interested can be involved in statistical analysis, (SAS, STATA etc). The student’s role can be tailored to fit interests and skills; all are encouraged to apply. The student will gain skills in literature searches, citation management, epidemiologic and health services research studies, health disparities, biostatistics, and rheumatic conditions affecting children and young adults and their management.	1	Data construction, data quality, and interpretation	Tailorable	NA	Approved	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Bartels CM, Rosenthal A, Wang X, Ahmad U, Chang I, Ezeh N, Garg S, Schletzbaum M, Kind A. Investigating Lupus Retention in Care to Inform Interventions for Disparities Reduction: An urban cohort study. Arthritis Research and Therapy. 2020; 22(1):35. Schletzbaum M, Chen Y, Sheehy A, Kaiksow F, Powell R, Gilmore-Bykovskyi A, Kind A, Bartels CM. Differences in 30-Day Rehospitalization Risk and Predictors by Age Group Among Patients with Lupus in Medicare. Target Journal: Arthritis Care and Research. Ezeh N* (Shapiro alum), McKown T, Garg S, Bartels CM. Smoking Exposure in Pack-Years Predicts Cutaneous Manifestations of Systemic Lupus Erythematosus. In Revision: Lupus.	Yes	Monica Messina Program Manager; Jason Weitzman Division Administrator	Retention in Healthcare among Young Patients with Lupus : Systemic Lupus Erythematous (SLE) affects 1.5 million Americans and is three times more common in people of minority race and ethnicity, who are more likely to have pediatric-onset SLE (pSLE). Young adults with SLE are 20 times more likely to die prematurely vs. peers and twice as likely to develop kidney disease vs. adult-onset SLE, yet staying in care and on therapy for SLE may reduce such risks. The goal of this project is to identify patient and context factors that predict such retention in healthcare and on treatment for lupus among pediatric patients using previously collected data from the national Childhood Arthritis and Rheumatology Research Alliance Registry. In other diseases such as HIV, patients retained in care and on therapy over time has been measured, correlated with disease outcomes, and used to targets improving care and health outcomes. The Bartels Lab is applying this framework to the care of adult and pediatric SLE patients to understand and quantify health disparities gaps with the aim of developing interventions to reduce health disparities in lupus. Specifically, the role of the student researcher will be to conduct a literature review, create new data variables (e.g., distance of residence from rheumatology care), conduct data quality audits, create figures, and write text for a scientific abstract and manuscript. The student will learn interpretation of statistical outputs, and if interested can be involved in statistical analysis, (SAS, STATA etc). The student’s role can be tailored to fit interests and skills; all are encouraged to apply. The student will gain skills in literature searches, citation management, epidemiologic and health services research studies, health disparities, biostatistics, and rheumatic conditions affecting children and young adults and their management. ____________________________________________________________________________ Role - Data construction, data quality, and interpretation; IRB Status - Approved; Skills - NA	Christie Bartels, cb4@medicine.wisc.edu -- Co-Mentor: Maria Schletzbaum schletzbaum@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueAplRmbXDtLx1M4k76HQt_dZ0-22OdU_Q-RFqatCeQ2Wwv0dSd-LBEeFDKE2oLr-s
13/01/2021	moreno@wisc.edu	Megan	Moreno	MD, MSEd, MPH	Professor of Pediatrics, Academic Division Chief for General Pediatrics and Adolescent Medicine	608	Pediatrics	General Pediatrics and Adolescent Medicine							Technology and Adolescent Mental Health	Our team: The Social Media and Adolescent Health Research Team (SMAHRT) has research internship openings which will provide immersive experiences for Shapiro medical students. SMAHRT’s mission is to advance our understanding of the relationships between media and adolescent health towards educating teens, providing better care, and developing innovations in adolescent health. SMAHRT is led by Dr. Megan Moreno, an adolescent medicine physician and researcher. Our multidisciplinary team includes undergraduate students, medical trainees and SMAHRT staff from various backgrounds of study including education, psychology and journalism. This experience includes the opportunity to work as part a research team that values diversity and collaboration, comprised of undergraduate students, staff, and investigators who serve as mentors and mentees. Our projects: Research interns will join our team to work on an ongoing project around social media and adolescent health. Example projects include: 1. Utilizing a large dataset focused on technology and adolescent mental health 2. Evaluating social media posts relevant to COVID-19 3. Examining the state of research related to social media and anxiety Our website: Read more about our research at our website here: www.smahrtresearch.com Our Facility: Our team’s work hours are from 8am-6pm M-F; we do our best to be flexible and work with your class schedule. Until further notice, our team conducts work entirely remotely using WebEx and Zoom.	0	Students will be team members and work on a primary project within the team as well as designing and conducting an individual research project in which they serve as PI.	Given the team culture and remote work environment, we value the ability to work independently to complete tasks and achieve goals	Facility with software for writing, references and presenting is helpful. Social media experience is also helpful.	All are approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Moreno MA, Ton A, Selkie E, Evans Y. Secret Society 123: Understanding the Language of Self-Harm on Instagram. J Adolesc Health. 2016 Jan;58(1):78-84. doi: 10.1016/j.jadohealth.2015.09.015. PubMed PMID: 26707231; PubMed Central PMCID: PMC5322804. Jelenchick LA, Hawk ST, Moreno MA. Problematic internet use and social networking site use among Dutch adolescents. Int J Adolesc Med Health. 2016 Feb;28(1):119-21. doi: 10.1515/ijamh-2014-0068. PubMed PMID: 25720115. Gritton J, Rushing SC, Stephens D, Ghost Dog T, Kerr B, Moreno MA. Responding to concerning posts on social media: Insights and solutions from American Indian and Alaska Native youth. Am Indian Alsk Native Ment Health Res. 2017;24(3):63-87. doi: 10.5820/aian.2403.2017.63. PubMed PMID: 29161455. Evans YN, Gridley SJ, Crouch J, Wang A, Moreno MA, Ahrens K, Breland DJ. Understanding Online Resource Use by Transgender Youth and Caregivers: A Qualitative Study. Transgend Health. 2017 Aug 1;2(1):129-139. doi: 10.1089/trgh.2017.0011. eCollection 2017. PubMed PMID: 29082333; PubMed Central PMCID: PMC5628561. Kelleher E, Wilt M, Moreno MA. #Depressed: A Randomized Controlled Trial Tumblr Pilot Intervention. Journal of Medical Internet Research. 2018; 7(4):e95. D'Angelo JD, Moreno MA. Not at the dinner table – take it to your room: adolescent reports of parental screen time rules. Communication Research Reports. 2019 October; 36(5):426-436. doi: 10.1080/08824096.2019.1683528. Cash S, Schwab-Reese LM, Zipfel E, Wilt M, Moreno MA. What College students Post About Depression on Facebook and the Support they Perceive: A Content Analysis. JMIR. 2019; doi: 10.2196/13650. [Epub ahead of print] URL: https://preprints.jmir.org/preprint/13650 Moreno MA, Eickhoff JC, Zhao QQ, Young HN, Cox ED. Problematic Internet Use: A longitudinal study evaluating prevalence and predictors. Journal of Pediatrics. 2019; NIHMSID: NIHMS1620764. doi: 10.1016/J.YMPDX.2019.100006. PMID: 27855666 PMCID: PMC5114822 Bryan MA, Evans Y, Morishita C, Midamba N, Moreno MA. Parental Perceptions of the Internet and Social Media as a Source of Pediatric Health Information. Acad Pediatr. 2020 Jan - Feb;20(1):31-38. doi: 10.1016/j.acap.2019.09.009. Epub 2019 Oct 21. PubMed PMID: 31648059. Moreno MA, Binger K, Zhao Q, Eickhoff J. Measuring Interests Not Minutes: Development and Validation of the Adolescents' Digital Technology Interactions and Importance Scale (ADTI). J Med Internet Res. 2020 Feb 12;22(2):e16736. doi: 10.2196/16736. PubMed PMID: 32049068. Kerr B, D'Angelo JD, Diaz-Caballero A, Moreno MA. College Student Problematic Internet Use and Digital Communication Medium Used With Parents: Cross-Sectional Study. JMIR Pediatr Parent. 2020 Apr 23;3(1):e17165. doi: 10.2196/17165. PubMed PMID: 32324140; PubMed Central PMCID: PMC7206513. Jolliff AF, Moreno MA, D'Angelo J. The mediating role of depressive and anxiety symptoms in the association between obesity and problematic social media use in young adults. Obes Sci Pract. 2020 Oct;6(5):454-459. doi: 10.1002/osp4.434. eCollection 2020 Oct. PubMed PMID: 33082987; PubMed Central PMCID: PMC7556436. Jolliff AF, Moreno MA. #TechAddicted: Understanding Problematic Internet Use in Adolescents. Pediatr Rev. 2020 Oct;41(10):554-555. doi: 10.1542/pir.2019-0249. PubMed PMID: 33004670. Chalmers K, Smith M, Moreno MA, Malik F. "It Got Likes, But I Don't Think People Understood": A Qualitative Study of Adolescent Experiences Discussing Type 1 Diabetes on Social Media. J Diabetes Sci Technol. 2020 Oct 27;:1932296820965588. doi: 10.1177/1932296820965588. [Epub ahead of print] PubMed PMID: 33106051. Kelleher EF, Giampietro PF, Moreno MA. Social Media Use Among Young Adults With Connective Tissue Disorders: Cross-Sectional Pilot Study. JMIR Pediatr Parent. 2020 Oct 30;3(2):e16367. doi: 10.2196/16367. PubMed PMID: 33124992. Gaus Q, Jolliff A, Moreno MA. A Content Analysis of YouTube Depression Personal Account Videos and their Comments. Computers in Human Behavior Reports Volume 3, January-July 2021, 100050. ISSN 2451-9588. https://doi.org/10.1016/j.chbr.2020.100050 Hamilton JL, Chand S, Reinhardt L, Ladouceur CD, Silk JS, Moreno MA, Franzen PL, Bylsma LM. Social media use predicts later sleep timing and greater sleep variability: An ecological momentary assessment study of youth at high and low familial risk for depression. J Adolesc. 2020 Aug;83:122-130. doi: 10.1016/j.adolescence.2020.07.009. Epub 2020 Aug 6. PMID: 32771847; PMCID: PMC7484414.	Yes	N/A	Technology and Adolescent Mental Health: Our team: The Social Media and Adolescent Health Research Team (SMAHRT) has research internship openings which will provide immersive experiences for Shapiro medical students. SMAHRT’s mission is to advance our understanding of the relationships between media and adolescent health towards educating teens, providing better care, and developing innovations in adolescent health. SMAHRT is led by Dr. Megan Moreno, an adolescent medicine physician and researcher. Our multidisciplinary team includes undergraduate students, medical trainees and SMAHRT staff from various backgrounds of study including education, psychology and journalism. This experience includes the opportunity to work as part a research team that values diversity and collaboration, comprised of undergraduate students, staff, and investigators who serve as mentors and mentees. Our projects: Research interns will join our team to work on an ongoing project around social media and adolescent health. Example projects include: 1. Utilizing a large dataset focused on technology and adolescent mental health 2. Evaluating social media posts relevant to COVID-19 3. Examining the state of research related to social media and anxiety Our website: Read more about our research at our website here: www.smahrtresearch.com Our Facility: Our team’s work hours are from 8am-6pm M-F; we do our best to be flexible and work with your class schedule. Until further notice, our team conducts work entirely remotely using WebEx and Zoom. ____________________________________________________________________________ Role - Students will be team members and work on a primary project within the team as well as designing and conducting an individual research project in which they serve as PI.; IRB Status - All are approved; Skills - Facility with software for writing, references and presenting is helpful. Social media experience is also helpful.	Megan Moreno, moreno@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucAYQ2SFz3ciSpoJ28798mcXvgAJOC51sYSe97AfU3NYPsb_Cok-qlZSn4HJ-O-6_U
14/01/2021	hbartlett2@wisc.edu	Heather	Bartlett	MD	Professor	6.082.626.253	Pediatrics	Cardiololgy	Medicine	Cardiology	Xiao Zhang	xiao.zhang@wisc.edu	Pediatrics	Cardiology	Use of medical therapy in adults with congenital heart disease and heart failure	The purpose of this study is to determine practice differences in heart failure treatment in adults with congenital heart disease and heart failure and compare this to the general population of adults with heart failure.	0	Data analysis	Moderate	Strong skills in communication, initiative, attention to detail, and follow through.	approved	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Genetic Counseling students	Menachem JN, Schlendorf KH, Mazurek JA, Bichell DP, Brinkley DM, Frischhertz BP, Mettler BA, Shah AS, Zalawadiya S, Book W, Lindenfeld J. Advanced Heart Failure in Adults With Congenital Heart Disease. JACC Heart Fail. 2020 Feb;8(2):87-99. doi: 10.1016/j.jchf.2019.08.012. Epub 2019 Dec 11. PMID: 31838031. Stout KK, Broberg CS, Book WM, et al. Chronic heart failure in congenital heart disease: a scientific statement from the American Heart Association. Circulation 2016;133:770–801. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147–239. Robbins JM, Onukwube J, Goudie A, Collins RT 2nd. How often is congenital heart disease recognized as a significant comorbidity among hospitalized adults with congenital heart disease? Int J Cardiol. 2017 May 15;235:42-48. doi: 10.1016/j.ijcard.2017.02.100. Epub 2017 Feb 22. PMID: 28279500; PMCID: PMC5427637. Khan A, Ramsey K, Ballard C, Armstrong E, Burchill LJ, Menashe V, Pantely G, Broberg CS. Limited accuracy of administrative data for the identification and classification of adult congenital heart disease.J Am Heart Assoc. 2018; 7:e007378. doi:10.1161/JAHA.117.007378.	Yes	Xiao Zhang	Use of medical therapy in adults with congenital heart disease and heart failure: The purpose of this study is to determine practice differences in heart failure treatment in adults with congenital heart disease and heart failure and compare this to the general population of adults with heart failure. ____________________________________________________________________________ Role - Data analysis; IRB Status - approved; Skills - Strong skills in communication, initiative, attention to detail, and follow through.	Heather Bartlett, hbartlett2@wisc.edu -- Co-Mentor: Xiao Zhang xiao.zhang@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufkxLTVjoD6h_o9l7XMYNA_FyuG4YL8MyBjdxhhdKcjFPW1vJxSLp_svEFnkPaNIPc
14/01/2021	elfenbein@surgery.wisc.edu	Dawn	Elfenbein	MD, MPH	Associate Professor of Surgery	4.102.742.658	Surgery	Endocrine Surgery			Mariam Ali-Mucheru	alimucheru@surgery.wisc.edu	Surgery	Endocrine Surgery	Parathyroidectomy in Octagenerians	Parathyroidectomy for primary hyperparathyroidism is a surgery where maximum benefit is reached 5-10 years after surgery. Long term follow up of patients who are in their 80's at the time of surgery is not widely reported. We have a database of over 300 people who underwent this surgery while over the age of 80, and this project will comprise of: 1) literature review on the topic, 2) hypothesis generation, 3) data gathering from medical record chart review, 4) data analysis, 5) anstract submission, 6) manuscript writing and publication	0	See description of project. The student will be mentored throughout all aspects of the research process from literature review and hypothesis generation through manuscript writing.	Will need to be able to access HealthLink and abstract data from medical record, but will provide guidance as much or as little as the student needs	Excel database skills, writing skills	N/A	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Lou I, Schneider DF, Sippel RS, Chen H, Elfenbein DM. The Changing Pattern of Diagnosing Primary Hyperparathyroidism in Young Patients. Am J Surg. 2017 Jan; 213(1):146-150.PMID: 27392754 Madkhali TM, Alhefdhi A, Chen H, Elfenbein DM. Primary Hyperparathyroidism. Turkish J of Surg.(Ulus Cerrahi Derg.) 2016 Mar 1;32(1):58-66. PMID: 26985167 Tobin K, Ayers RR, Rajaei M, Sippel RS, Balentine CJ, Elfenbein DM, Chen H, Schndeider DF. Use of the gamma probe to identify multigland disease in primary hyperparathyroidism. Int J Endo Oncol. 2016 Feb;3(1),13-19. PMID: 27127604	Yes	Emily Romdenne - romdenne@surgery.wisc.edu	Parathyroidectomy in Octagenerians: Parathyroidectomy for primary hyperparathyroidism is a surgery where maximum benefit is reached 5-10 years after surgery. Long term follow up of patients who are in their 80's at the time of surgery is not widely reported. We have a database of over 300 people who underwent this surgery while over the age of 80, and this project will comprise of: 1) literature review on the topic, 2) hypothesis generation, 3) data gathering from medical record chart review, 4) data analysis, 5) anstract submission, 6) manuscript writing and publication ____________________________________________________________________________ Role - See description of project. The student will be mentored throughout all aspects of the research process from literature review and hypothesis generation through manuscript writing.; IRB Status - N/A; Skills - Excel database skills, writing skills	Dawn Elfenbein, elfenbein@surgery.wisc.edu -- Co-Mentor: Mariam Ali-Mucheru alimucheru@surgery.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuf_XQ2oeKIF7QQsolgJ8fu8iZdJ9hp8djbNFqMdhGBbC35eGsBrrv1SJc9Gvohn3F0
14/01/2021	ssmccoy@medicine.wisc.edu	Sara	McCoy	MD	assistant professor	16.082.620.908	Medicine	Rheumatology			Karen Hansen	keh@medicine.wisc.edu	Medicine	Rheumatology	Sjogren's Syndrome-The UW Registry	Sjogren's syndrome (SS) is an autoimmune disease with cardinal symptoms of dry eyes and mouth but is a systemic disease that can affect multiple organ systems. SS leads to increased patient morbidity and healthcare costs. Unfortunately, the pathophysiology of SS is poorly understood, leading to significant gaps in diagnosis and treatment of this common disease. No FDA approved treatment for SS exists. Instead, treatment focuses on specific organ involvement, using globally immunosuppressive medications. By understanding the pathogenesis of SS, we can create targeted and better tolerated therapies. Toward this end, we aim to establish the first UW retrospective SS repository. The repository will be composed of clinical data on primary and secondary SS and include a control group composed of patients with sicca who do not have a systemic autoimmune disease. We seek a scholar to perform chart review and data abstraction, using a standardized tool. The scholar will become proficient with review of medical records in the electronic database, Epic, and will abstract data to enter into the repository. Once data abstraction is complete, the first project will involve evaluating the association of SS with osteoporosis based on bone mineral density test results. SS is a female predominant disease (20:1 female to male) and we have established that estrogen appears to reduce the development of SS. Thus we would like to evaluate how osteoporosis, a disease strongly associated with estrogen exposure, is associated with SS.	0	Data abstraction and preliminary analysis	Moderate	Data abstraction, fluency	Approved	No	Funding from DOM	Yes	Research Electives for credit	MPH students, PhD students, UW undergraduates interested in research	Association of Sjögren's Syndrome With Reduced Lifetime Sex Hormone Exposure: A Case-Control Study. McCoy SS, Sampene E, Baer AN. Arthritis Care Res (Hoboken). 2020 Sep;72(9):1315-1322. doi: 10.1002/acr.24014. PMID: 31233285	No	Jason Weitzman jweitzman@medicine.wisc.edu	Sjogren's Syndrome-The UW Registry: Sjogren's syndrome (SS) is an autoimmune disease with cardinal symptoms of dry eyes and mouth but is a systemic disease that can affect multiple organ systems. SS leads to increased patient morbidity and healthcare costs. Unfortunately, the pathophysiology of SS is poorly understood, leading to significant gaps in diagnosis and treatment of this common disease. No FDA approved treatment for SS exists. Instead, treatment focuses on specific organ involvement, using globally immunosuppressive medications. By understanding the pathogenesis of SS, we can create targeted and better tolerated therapies. Toward this end, we aim to establish the first UW retrospective SS repository. The repository will be composed of clinical data on primary and secondary SS and include a control group composed of patients with sicca who do not have a systemic autoimmune disease. We seek a scholar to perform chart review and data abstraction, using a standardized tool. The scholar will become proficient with review of medical records in the electronic database, Epic, and will abstract data to enter into the repository. Once data abstraction is complete, the first project will involve evaluating the association of SS with osteoporosis based on bone mineral density test results. SS is a female predominant disease (20:1 female to male) and we have established that estrogen appears to reduce the development of SS. Thus we would like to evaluate how osteoporosis, a disease strongly associated with estrogen exposure, is associated with SS. ____________________________________________________________________________ Role - Data abstraction and preliminary analysis; IRB Status - Approved; Skills - Data abstraction, fluency	Sara McCoy, ssmccoy@medicine.wisc.edu -- Co-Mentor: Karen Hansen keh@medicine.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueDyEI9DGHnrh0-Un8c43RMk8Affsvxe5vbgBmBpq-pbsCzwqx8nxCaLxrK_hRbsA8
15/01/2021	berian@wisc.edu	Julia	Berian	MD, MS	Assistant Professor	6.082.634.224	Surgery	Colorectal Surgery							Optimizing Surgical Outcomes for Older Adults	I collaborate with the Geriatrics-run Perioperative Optimization of Senior Health (POSH) Clinic to study how we evaluate and prepare older adults for surgery, with the goal to promote return to independence after their recovery.	0	Literature review, Chart review, Qualitative methods (interviews, focus groups)	Commensurate with ability	Critical appraisal of medical literature, Organization, HIPAA compliance, Interpersonal skills for possible patient interactions	Pending	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	DPT students, MPH students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	McDonald SR, et al. Association of Integrated Care Coordination With Postsurgical Outcomes in High-Risk Older Adults: The Perioperative Optimization of Senior Health (POSH) Initiative. JAMA Surg. 2018 May 1;153(5):454-462. doi: 10.1001/jamasurg.2017.5513. PMID: 29299599; Partridge JS, Harari D, Martin FC, Dhesi JK. The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia. 2014 Jan;69 Suppl 1:8-16. doi: 10.1111/anae.12494. PMID: 24303856; Suwanabol PA, Li Y, Abrahamse P, et al. Functional and Cognitive Decline Among Older Adults After High-Risk Surgery. Ann Surg. 2020 May 11. doi: 10.1097/SLA.0000000000003950. [Online ahead of print.] PMID: 32404660	No	Emily Romdenne, romdenne@surgery.wisc.edu	Optimizing Surgical Outcomes for Older Adults: I collaborate with the Geriatrics-run Perioperative Optimization of Senior Health (POSH) Clinic to study how we evaluate and prepare older adults for surgery, with the goal to promote return to independence after their recovery. ____________________________________________________________________________ Role - Literature review, Chart review, Qualitative methods (interviews, focus groups); IRB Status - Pending; Skills - Critical appraisal of medical literature, Organization, HIPAA compliance, Interpersonal skills for possible patient interactions	Julia Berian, berian@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufMAXsFthTBnvREqy61XvGxd-VOZxizf8Yc9a7HjdTph1kNB57tiFNYlL4JBTLANR4
18/01/2021	sara.lindberg@wisc.edu	Sara	Lindberg	PhD, MS	Director of Evaluation Research & Assistant Professor (CHS)	6.082.626.008	Population Health Sciences	UW Population Health Institute							Evaluation of the Community-Academic Aging Research Network	The Community Academic Aging Research Network (CAARN; https://caarn.wisc.edu/) is expanding strategies to support authentic partnership between community and academic partners engaged in collaborative research. CAARN is interested in building partners’ capacity to use key principles and practices that are known to support successful community-based participatory research (CBPR) partnerships. UWPHI is partnering with CAARN in the evaluation of these efforts. Data from multiple stakeholders and multiple methods will be combined to understand the extent to which community-based participatory research principles are working in the CAARN network, among its staff and leadership, and among affiliated research teams. Depending on student interest, this opportunity could include broader exposure to the CAARN research team. If this is of interest, let's discuss.	1	Conduct qualitative interviews & qualitative analysis	Moderate - After a period of training, student will need to do some work independently. Regular check-ins will ensure that students learn best practices of qualitative and mixed methods research.	Strong inter-personal skills; active listening; cultural humility; attention to detail; Respect for persons and confidentiality	Exempt; Not Human Subjects Research (It's program evaluation)	Yes	TBD	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	https://caarn.wisc.edu/publications/	Yes	N/A	Evaluation of the Community-Academic Aging Research Network: The Community Academic Aging Research Network (CAARN; https://caarn.wisc.edu/) is expanding strategies to support authentic partnership between community and academic partners engaged in collaborative research. CAARN is interested in building partners’ capacity to use key principles and practices that are known to support successful community-based participatory research (CBPR) partnerships. UWPHI is partnering with CAARN in the evaluation of these efforts. Data from multiple stakeholders and multiple methods will be combined to understand the extent to which community-based participatory research principles are working in the CAARN network, among its staff and leadership, and among affiliated research teams. Depending on student interest, this opportunity could include broader exposure to the CAARN research team. If this is of interest, let's discuss. ____________________________________________________________________________ Role - Conduct qualitative interviews & qualitative analysis; IRB Status - Exempt; Not Human Subjects Research (It's program evaluation); Skills - Strong inter-personal skills; active listening; cultural humility; attention to detail; Respect for persons and confidentiality	Sara Lindberg, sara.lindberg@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufgOvXRHmlUdmoMPGTu3njcZLfH0-MrvizxqR-X8KL1lTMI3FZhszJoCumjyHGoxWQ
18/01/2021	sara.lindberg@wisc.edu	Sara	Lindberg	PhD, MS	Director of Evaluation Research & Assistant Professor (CHS)	6.082.626.008	Population Health Sciences	UW Population Health Institute							Evaluation of the Diversity & Inclusion Advocates Program	The Diversity and Inclusion Advocates (DIA) Program launched in January 2018, as an initiative of the UW School of Medicine and Public Health (SMPH). The program grew out of perceived need to increase SMPH resources to address and implement schoolwide diversity and inclusion practices. The objective of the DIA Program is to train and promote a cohort of trusted leaders across SMPH that have an understanding of how to access resources, provide advice and consultation to support greater diversity in faculty hiring processes, and address issues that ensure more equitable and inclusive policies and practices across SMPH. In collaboration with the DIA program leadership team, the UW Population Health Institute (UWPHI) is supporting program evaluation. The current stage of evaluation focuses on the development on individual D&I Advocates, their experiences in the role, their personal growth and leadership development, as well as practices that have emerged within their spheres of influence.	1	Conduct qualitative interviews & qualitative analysis	Moderate - After a period of training, student will need to do some work independently. Regular check-ins will ensure that students learn best practices of qualitative and mixed methods research.	Strong inter-personal skills; active listening; cultural humility; attention to detail; Respect for persons and confidentiality	Exempt; Not Human Subjects Research (It's program evaluation)	No	No (plan to use Dean's Office Funds)	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	https://intranet.med.wisc.edu/diversity-and-inclusion-advocates/	Yes	N/A	Evaluation of the Diversity & Inclusion Advocates Program: The Diversity and Inclusion Advocates (DIA) Program launched in January 2018, as an initiative of the UW School of Medicine and Public Health (SMPH). The program grew out of perceived need to increase SMPH resources to address and implement schoolwide diversity and inclusion practices. The objective of the DIA Program is to train and promote a cohort of trusted leaders across SMPH that have an understanding of how to access resources, provide advice and consultation to support greater diversity in faculty hiring processes, and address issues that ensure more equitable and inclusive policies and practices across SMPH. In collaboration with the DIA program leadership team, the UW Population Health Institute (UWPHI) is supporting program evaluation. The current stage of evaluation focuses on the development on individual D&I Advocates, their experiences in the role, their personal growth and leadership development, as well as practices that have emerged within their spheres of influence. ____________________________________________________________________________ Role - Conduct qualitative interviews & qualitative analysis; IRB Status - Exempt; Not Human Subjects Research (It's program evaluation); Skills - Strong inter-personal skills; active listening; cultural humility; attention to detail; Respect for persons and confidentiality	Sara Lindberg, sara.lindberg@wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudgY8kCZ4XKVw8CxnPFR6aUpewCrC6Jbyn0bC75WguIlwqS9YYv-lU2NrgiymxX1m4
20/01/2021	savage@surgery.wisc.edu	Stephanie	Savage	MD, MS	Professor of Surgery	6.082.632.474	Surgery	Acute Care and Regional General Surgery							Evaluating coagulopathy in the setting of cirrhosis and liver transplantation	We are utilizing thromboelastography (TEG) to assess subtle derangements in clotting function in patients immediately before and after liver transplantation. At the current stage, the project will involve data abstraction from the Electronic Medical Record (currently about 2/3 complete). When the data set is complete, we will analyse using a variety of statistical methods to look for abnormalities in the clotting cascade.	0	Data abstraction, possibly writing parts of the abstract and manuscript	Once trained on the EMR, students should be able to perform data abstraction independently. Any writing will be done in conjunction with myself.	Familiarity with basic vitals and lab values, attention to detail, ability to navigate the medical record.	Approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects, Research Electives for credit	UW undergraduates interested in research	Savage SA, Zarzaur BL, Pohlman TH etal. "Clot dynamics and mortality: the MA-R ratio." J Trauma Acute Care Surg 2017;83(4)628-34. Savage SA, Zarzaur BL, Gaski GE etal. "Insights into the association between coagulopathy and inflammation: abnormal clot mechanics as a warning of immunologic dysregulation following major injury." Ann Transl Med 2020;8(23).	No	Margaret Carney (carney@surgery.wisc.edu)	Evaluating coagulopathy in the setting of cirrhosis and liver transplantation: We are utilizing thromboelastography (TEG) to assess subtle derangements in clotting function in patients immediately before and after liver transplantation. At the current stage, the project will involve data abstraction from the Electronic Medical Record (currently about 2/3 complete). When the data set is complete, we will analyse using a variety of statistical methods to look for abnormalities in the clotting cascade. ____________________________________________________________________________ Role - Data abstraction, possibly writing parts of the abstract and manuscript; IRB Status - Approved; Skills - Familiarity with basic vitals and lab values, attention to detail, ability to navigate the medical record.	Stephanie Savage, savage@surgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueQr9BICjbaSCyjoh4tNDpoy2sPRKAfJqI2_MfcbIg70YCI2d67TdzqXD21pNbz9n8
20/01/2021	ns2@medicine.wisc.edu	nasia	safdar	MD, PhD	Professor	608	Medicine	infectious diseases			Laura Anderson		Medicine	infection control	Infection prevention in health systems	several ongoing infection control projects, covid and non covid. Examples are observations of changes in PPE/masking/distancing following vaccination, cluster investigations, modelling of infectious diseases	0	data collection, analysis, write up	high	good writing and data display (excel or similar) skills	quality improvement	Yes	department covers	Yes	Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	several-best viewed on pubmed	Yes	michelle zimbric mzimbric@medicine.wisc.edu	Infection prevention in health systems: several ongoing infection control projects, covid and non covid. Examples are observations of changes in PPE/masking/distancing following vaccination, cluster investigations, modelling of infectious diseases ____________________________________________________________________________ Role - data collection, analysis, write up; IRB Status - quality improvement; Skills - good writing and data display (excel or similar) skills	nasia safdar, ns2@medicine.wisc.edu -- Co-Mentor: Laura Anderson	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufFGMIdDTjwRebvL7HJqQuKSfUWwmGHk36fBHzKCIZfBfiJVJQQ5X6XvYzsq7KpNc4
20/01/2021	jarrard@urology.wisc.edu	david	jarrard	md	Professor and Vice Chair	6.082.652.225	Urology	Oncology							Predicting prostate cancer presence in histologically benign biopsy tissue	The Jarrard research programs utilize translational and clinical research to examine aspects underlying prostate cancer development and progression. Using our established database of over 2000 patients we have published with previous Shapiro students on identifying features that help better predict and guide the management of patients with this disease. The current project is utilizes computer based digital imaging and epigenetic molecular changes to examine features on non-tumor prostate biopsies that predict the presence of cancer. This builds on several previous observations and seeks to improve the diagnosis of prostate cancer.	1	data collection and analysis, abstract and manuscript writing, IRB status- approved	moderate	computer skills a plus	approved	Yes	Yes	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Yang B, Etheridge T, McCormick J, Schultz A, Khemees TA, Damaschke N, Leverson G, Woo K, Sonn GA, Klein EA, Fumo M, Huang W, Jarrard DF. Validation of an epigenetic field of susceptibility to detect significant prostate cancer from non-tumor biopsies. Clin Epigenetics. 2019 Nov 28;11(1):168. PMID: 31779677; PMCID: PMC6883627. Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS. Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network. J Med Imaging (Bellingham). 2020 Sep;7(5):057501PMID: 33062803; PMCID: PMC7550797.	Yes	Steve Hall hall@urology.wisc.edu	Predicting prostate cancer presence in histologically benign biopsy tissue: The Jarrard research programs utilize translational and clinical research to examine aspects underlying prostate cancer development and progression. Using our established database of over 2000 patients we have published with previous Shapiro students on identifying features that help better predict and guide the management of patients with this disease. The current project is utilizes computer based digital imaging and epigenetic molecular changes to examine features on non-tumor prostate biopsies that predict the presence of cancer. This builds on several previous observations and seeks to improve the diagnosis of prostate cancer. ____________________________________________________________________________ Role - data collection and analysis, abstract and manuscript writing, IRB status- approved; IRB Status - approved; Skills - computer skills a plus	david jarrard, jarrard@urology.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc1fB_X7YB8tOBU0tZMWcSC4I8uz7j4RT8rjIJQ5tHvQv-nXA8UT1LvhsMY7-V6Ieo
20/01/2021	whiting@ortho.wisc.edu	Paul	Whiting	MD	Director of Orthopaedic Trauma Research, Assistant Professor	6.082.659.433	Orthopedics and Rehabilitation	Orthopaedic Trauma			Seth Williams MD	swilliams@ortho.wisc.edu	Orthopedics and Rehabilitation	Spine Surgery	Multidisciplinary Opioid Reduction Program for Orthopaedic Trauma Patients	Data collection and analysis will be performed on patients admitted to the hospital for treatment of Orthopaedic Trauma over a three-year period. The project will specifically investigate opioid medication usage before (calendar year 2018), during (calendar year 2019), and after (calendar year 2020) implementation of a multidisciplinary opioid reduction program. The primary outcomes of interest will be total inpatient opioid consumption and outpatient opioid medication prescription amounts provided upon discharge from the hospital. In addition, if this entire project is able to be completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor).	0	The student will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission	The student will be expected to be able to accomplish all of the above tasks and work toward accomplishing these components of the project independently. However, appropriate guidance and direction will be provided (by the PI/co-investigators, research coordinator, and other research support staff) at the outset of the project and throughout the summer. We will schedule weekly meetings with the PI and/or other investigators/research staff. The purpose of these meetings will be to monitor project progress. Ongoing supervision/mentorship will be provided after the summer and throughout the process of abstract/manuscript submission/presentation/publication.	The following skills are expected/required: - perform a literature search and compile a list of manuscript references. - perform chart review in conjunction with mentors/co-investigators - maintain database (likely REDCap-based) - Meet with the statistician to determine the statistical tools that will be used to analyze the data - Participate in abstract/manuscript preparation/submission	Pending (IRB application is being finalized). Since this will be a retrospective chart-review study, we do not anticipate any issues with IRB approval being obtained prior to the start of the Shapiro Summer Research Program.	No	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	No specific manuscripts directly related to this project.	Yes	Heidi Ableidinger (Student Services Coordinator) Ableidinger@ortho.wisc.edu Kristina Johnson (Ortho Trauma Research Coordinator) otrc@ortho.wisc.edu	Multidisciplinary Opioid Reduction Program for Orthopaedic Trauma Patients: Data collection and analysis will be performed on patients admitted to the hospital for treatment of Orthopaedic Trauma over a three-year period. The project will specifically investigate opioid medication usage before (calendar year 2018), during (calendar year 2019), and after (calendar year 2020) implementation of a multidisciplinary opioid reduction program. The primary outcomes of interest will be total inpatient opioid consumption and outpatient opioid medication prescription amounts provided upon discharge from the hospital. In addition, if this entire project is able to be completed prior to the conclusion of the Shapiro Summer Research Program, the student will have opportunities to assist with other ongoing research projects under the direction of Dr. Paul Whiting (primary mentor) and/or Dr. Seth Williams (co-mentor). ____________________________________________________________________________ Role - The student will be expected to participate in the following components of this project: - literature search - data collection - data analysis - manuscript and abstract preparation - manuscript and abstract submission; IRB Status - Pending (IRB application is being finalized). Since this will be a retrospective chart-review study, we do not anticipate any issues with IRB approval being obtained prior to the start of the Shapiro Summer Research Program.; Skills - The following skills are expected/required: - perform a literature search and compile a list of manuscript references. - perform chart review in conjunction with mentors/co-investigators - maintain database (likely REDCap-based) - Meet with the statistician to determine the statistical tools that will be used to analyze the data - Participate in abstract/manuscript preparation/submission	Paul Whiting, whiting@ortho.wisc.edu -- Co-Mentor: Seth Williams MD swilliams@ortho.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnue6vMXw_Zkj7kqxzA34BRp3tYKxJ3Tojjv1tDWv7xgdBgGXvsqT-tTr4FTR4GqIRaY
20/01/2021	swilliams@ortho.wisc.edu	Seth	Williams	MD	Associate Professor, Clinical Vice Chair	6.082.346.717	Orthopedics and Rehabilitation	Spine Surgery			James Bernatz, MD	JBernatz@uwhealth.org	Orthopedics and Rehabilitation	Orthopedic Surgery Resident	Subsidence of interbody fusion cages in spine surgery	Interbody spine fusions are common procedures that uses metal or PEEK structural cages, bone substitutes and other products for placement between vertebrae in order to achieve fusion of the bones. Subsidence is a known phenomena in which the interbody device “sinks in” to the vertebral bodies above and below the cage, which can cause untoward radiographic and clinical outcomes. There is no established gold standard for measuring subsidence. We have developed a novel method for the measurement of subsidence on radiographs. The purpose of the project is to quantitatively measure subsidence after a variety of spine surgeries and correlate it to surgical factors (graft choice, surgical level) as well as patient factors (comorbid conditions, obesity, osteoporosis, etc.). Our early validation study for this project, though limited in scope, is very promising in terms of accuracy and reliability, and if we can show similar findings with larger patient numbers, this project has potential to be very meaningful and frequently referenced. There is also potential to be involved in other projects that are underway, including our Pain Plan Research from last summer’s Shapiro project, depending on how quickly the student moves through this primary project.	1	The student will identify a cohort of patients who underwent a particular interbody fusion procedure (e.g. lateral interbody fusion) and will measure subsidence with the technique we have developed. The student will extract various patient factors from the electronic medical record. The student will import these data into a data sheet, from which we will generate statistical correlations. The student will prepare one (or more) manuscripts from this project to be published in spine journals. It is expected that the medical student will be first author on one of the publication(s) that he/she generates.	Moderate	Basic understanding of PACS (imaging review system) and Health Link (electronic medical record) – both of which can be taught. Powerpoint, excel, basic data sheet management.	Approved	No	No (plan to use Dean's Office Funds)	The student will need their own laptop computer.	Shorter term projects	Not currently available to mentor other students	None	Yes	Erica Fry (Fry@ortho.wisc.edu), Sydney Ryback (Ryback@ortho.wisc.edu)	Subsidence of interbody fusion cages in spine surgery: Interbody spine fusions are common procedures that uses metal or PEEK structural cages, bone substitutes and other products for placement between vertebrae in order to achieve fusion of the bones. Subsidence is a known phenomena in which the interbody device “sinks in” to the vertebral bodies above and below the cage, which can cause untoward radiographic and clinical outcomes. There is no established gold standard for measuring subsidence. We have developed a novel method for the measurement of subsidence on radiographs. The purpose of the project is to quantitatively measure subsidence after a variety of spine surgeries and correlate it to surgical factors (graft choice, surgical level) as well as patient factors (comorbid conditions, obesity, osteoporosis, etc.). Our early validation study for this project, though limited in scope, is very promising in terms of accuracy and reliability, and if we can show similar findings with larger patient numbers, this project has potential to be very meaningful and frequently referenced. There is also potential to be involved in other projects that are underway, including our Pain Plan Research from last summer’s Shapiro project, depending on how quickly the student moves through this primary project. ____________________________________________________________________________ Role - The student will identify a cohort of patients who underwent a particular interbody fusion procedure (e.g. lateral interbody fusion) and will measure subsidence with the technique we have developed. The student will extract various patient factors from the electronic medical record. The student will import these data into a data sheet, from which we will generate statistical correlations. The student will prepare one (or more) manuscripts from this project to be published in spine journals. It is expected that the medical student will be first author on one of the publication(s) that he/she generates.; IRB Status - Approved; Skills - Basic understanding of PACS (imaging review system) and Health Link (electronic medical record) – both of which can be taught. Powerpoint, excel, basic data sheet management.	Seth Williams, swilliams@ortho.wisc.edu -- Co-Mentor: James Bernatz, MD JBernatz@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufDAu37RP4SXtRpe-_IH1G_rCmfuuc_QbGvfbCjOYuWYK7PBSUE8Xu7OYHXgZ0-0xQ
28/01/2021	cb4@medicine.wisc.edu	Christie	Bartels	MD MS	Associate Professor, Chief of Rheumatology	608	Medicine	Rheumatology			Edmond Ramly, PhD	ramly@wisc.edu	Family Medicine and Community Health	Affiliate, Industrial and Systems Engineering	Primary Care Follow Up on High Blood Pressure among Specialty Patients	Recognizing high blood pressure (BP) as the most prevalent cardiovascular risk factor in patients with rheumatic diseases and all adults, experts recommend clinic protocols to improve BP control. We developed and implemented BP Connect in a number of specialty clinics including three rheumatology clinics and two gynecology clinics at UW Health. Medical assistants and nurses were trained to 1) check (re-measuring BPs ≥140/90 mm Hg), 2) advise (linking rheumatic and cardiovascular diseases), and 3) connect (timely primary care follow-up using protocoled electronic health record [EHR] orders). The goal of this project is to characterize the content of primary care follow up visits taking place after high BP referral from rheumatology, by performing EHR chart abstraction. Our previous statistical analyses of EHR data showed that BP Connect doubled the odds of timely follow-up (<4 weeks), with sustained improvements over five years. This project will examine the follow-up actions documented by primary care providers in follow-up visits, to understand and quantify the impact of the referrals from rheumatology on the work performed in primary care and on the steps taken to manage high BP for referred patients. Specifically, the role of the student researcher will be to use a structured chart abstraction form to collect data from patient records in the EHR, create figures and tables, conduct literature searches, and write text for a scientific abstract and manuscript. The student will learn chart abstraction using REDCap and interpretation of statistical outputs. The student’s role can be tailored to fit interests and skills; all are encouraged to apply. This would be relevant to students interested in implementation research or practice improvement. The student will additionally gain skills in health services research and implementation studies, literature searches, citation management, and cardiovascular disease prevention in patients with rheumatic conditions and in specialty gyn clinics where these interventions are being studied.	1	Medical record abstraction	moderate	No prior skills required	Exempt	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	C M Bartels, E Ramly, HM Johnson, D R Lauver, DJ Panyard, Z Li, E Sampene, K Lewicki, P E McBride. Connecting Rheumatology Patients to Primary Care for High Blood Pressure: Specialty Clinic Protocol Improves Follow-up and Population Blood Pressures Arthritis Care Res. 2019 Apr;71(4):461-470. doi: 10.1002/acr.23612. PMID: 29856134 PMCID: PMC6274604 DOI: 10.1002/acr.23612 Share Ramly E, Stroik B (Shapiro Student), Lauver DR, Johnson HM, McBride P, Steffen Lewicki K, Arnason J, Bartels CM. Assessing Unwanted Variations in Rheumatology Clinic Previsit Rooming. J Clin Rheumatol. 2019 Apr;25(3):e1-e7. doi: 10.1097/RHU.0000000000000795. PMID: 29757802 Free PMC article. Wattiaux A (Med Student), Bettendorf B, Block L, Gilmore-Bykovskyi A, Ramly E, Piper ME, Rosenthal A, Sadusky J, Cox E, Chewning B, Bartels CM. Patient Perspectives on Smoking Cessation and Interventions in Rheumatology Clinics. Arthritis Care Res (Hoboken). 2020 Mar;72(3):369-377. doi: 10.1002/acr.23858. PMID: 30768768	Yes	Monica Messina, Jason Weitzman	Primary Care Follow Up on High Blood Pressure among Specialty Patients: Recognizing high blood pressure (BP) as the most prevalent cardiovascular risk factor in patients with rheumatic diseases and all adults, experts recommend clinic protocols to improve BP control. We developed and implemented BP Connect in a number of specialty clinics including three rheumatology clinics and two gynecology clinics at UW Health. Medical assistants and nurses were trained to 1) check (re-measuring BPs ≥140/90 mm Hg), 2) advise (linking rheumatic and cardiovascular diseases), and 3) connect (timely primary care follow-up using protocoled electronic health record [EHR] orders). The goal of this project is to characterize the content of primary care follow up visits taking place after high BP referral from rheumatology, by performing EHR chart abstraction. Our previous statistical analyses of EHR data showed that BP Connect doubled the odds of timely follow-up (<4 weeks), with sustained improvements over five years. This project will examine the follow-up actions documented by primary care providers in follow-up visits, to understand and quantify the impact of the referrals from rheumatology on the work performed in primary care and on the steps taken to manage high BP for referred patients. Specifically, the role of the student researcher will be to use a structured chart abstraction form to collect data from patient records in the EHR, create figures and tables, conduct literature searches, and write text for a scientific abstract and manuscript. The student will learn chart abstraction using REDCap and interpretation of statistical outputs. The student’s role can be tailored to fit interests and skills; all are encouraged to apply. This would be relevant to students interested in implementation research or practice improvement. The student will additionally gain skills in health services research and implementation studies, literature searches, citation management, and cardiovascular disease prevention in patients with rheumatic conditions and in specialty gyn clinics where these interventions are being studied. ____________________________________________________________________________ Role - Medical record abstraction; IRB Status - Exempt; Skills - No prior skills required	Christie Bartels, cb4@medicine.wisc.edu -- Co-Mentor: Edmond Ramly, PhD ramly@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufTuX56joXSwVr5UqEYy6XCMkJm9FSH-LcpzHOBWY0HBtC3t-Zoi2jrCMwk-hScK4s
28/01/2021	raalexanian@medicine.wisc.edu	Ruben	Alexanian	MD	Assistant Professor	6.085.093.875	Medicine	Interventional Cardiology							Tissue Engineering Heart Valves	Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, either surgically, which imposes the use of indefinite therapeutic anticoagulation when a mechanical valve is utilized; or more recently transcatheter bioprosthetic valve replacement, hindered by long-term valve durability. Ectopic calcification is the main cause of failure of bioprosthetic valves as a result of cytotoxic effects of crosslinking agents (xenografts), tissue alterations caused by cryopreservation/thawing (allografts), graft-versus host rejection, and imperfections in bioprosthetic valve hemodynamics leading to tissue injury and infiltration of innate immune cells implicated in valve degeneration. Bioengineered, stem cell derived, heart valve scaffolds with or without autologous cells may provide an alternative to current mechanical and bioprosthetic valve implants, with reduced propensity for both thrombosis and dystrophic calcification respectively. The proposed study will utilize human pluripotent derived fibroblast cells combined with decellularized valve extracellular matrix to construct a bioengineered autologous heart valve scaffold resistant to premature dystrophic calcification. These bioengineered scaffolds will be sutured unto a stented construct in collaboration with a commercially available valve companies to produce a functional tri-leaflet valve, which will be tested in animal models.	1	The qualified candidate will conduct bench top research including isolating aortic valve leaflets from pig hearts followed by chemical de-cellularization and re-celluarization utilizing pluripotent derived cells.	High	basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred	N/A	No	No (plan to use Dean's Office Funds)	Yes	Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	PhD students, UW undergraduates interested in research	n/a	Yes	n/a	Tissue Engineering Heart Valves: Calcific aortic valve disease is a major public health problem with significant morbidity and mortality. Mainstay of current therapies has been limited to aortic valve replacement, either surgically, which imposes the use of indefinite therapeutic anticoagulation when a mechanical valve is utilized; or more recently transcatheter bioprosthetic valve replacement, hindered by long-term valve durability. Ectopic calcification is the main cause of failure of bioprosthetic valves as a result of cytotoxic effects of crosslinking agents (xenografts), tissue alterations caused by cryopreservation/thawing (allografts), graft-versus host rejection, and imperfections in bioprosthetic valve hemodynamics leading to tissue injury and infiltration of innate immune cells implicated in valve degeneration. Bioengineered, stem cell derived, heart valve scaffolds with or without autologous cells may provide an alternative to current mechanical and bioprosthetic valve implants, with reduced propensity for both thrombosis and dystrophic calcification respectively. The proposed study will utilize human pluripotent derived fibroblast cells combined with decellularized valve extracellular matrix to construct a bioengineered autologous heart valve scaffold resistant to premature dystrophic calcification. These bioengineered scaffolds will be sutured unto a stented construct in collaboration with a commercially available valve companies to produce a functional tri-leaflet valve, which will be tested in animal models. ____________________________________________________________________________ Role - The qualified candidate will conduct bench top research including isolating aortic valve leaflets from pig hearts followed by chemical de-cellularization and re-celluarization utilizing pluripotent derived cells. ; IRB Status - N/A; Skills - basic knowledge of laboratory skills, previous experience with cell culture and biochemical methods is preferred	Ruben Alexanian, raalexanian@medicine.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueIok2anaF0o2kMAsb3HR2yEiNhZOKtWI7A4FclecF_JdaZxcqa-gwM0Lkv0w0gZOY
31/01/2021	afield@uwhealth.org	Aaron	Field	MD, PhD	Professor	6.082.134.863	Radiology	Neuroradiology	Medical Physics		Shahriar	Salamat	Pathology and Laboratory Medicine	Neuropathology	Quantitative MRI of Myelin: The Confounding Effects of Brain Tissue Iron Deposition	Several quantitative magnetic resonance imaging (MRI) techniques have recently been developed to assess the myelin content of cerebral white matter in vivo. These techniques may provide critically needed imaging biomarkers for studying multiple sclerosis and other diseases of white matter. However, the reliability of these techniques recently came under scrutiny when it was shown that under certain conditions, they may be sensitive to brain tissue iron deposition and thus provide inaccurate measurements. The purpose of this project is to study the effects of brain tissue iron deposition on quantitative magnetization transfer (qMT) imaging, using ex vivo human brain tissue slices that have been experimentally manipulated to alter their iron content. Specifically, formalin-fixed 1-cm brain tissue slices will be divided into left and right halves; one half will be soaked in an iron chelating agent to remove the iron content while the other half will serve as the control. The two halves will remain identical with respect to myelin content. Both halves will then undergo qMT imaging to measure the macromolecular proton fraction (MPF) in several regions known for accumulating iron deposits but also containing myelin, such as the basal nuclei. The MPF is an imaging metric recently promoted as a myelin biomarker, thus it should not significantly differ between iron-extracted and control samples. If it does, we will have shown that MPF is an unreliable myelin biomarker in the presence of tissue iron.	1	The student will first assist a neuropathologist to extract 1-2 whole brains during autopsy, fix them in formalin, slice them appropriately, and prepare control and iron-chelating buffer solutions for soaking the tissue slices before imaging. The student will then assist a MRI physicist in preparing the tissue slices in a suitable container to then perform the qMT imaging. Finally, the student will assist the physicist to process the images, derive region-based measurements of MPF and statistically compare them between iron-extracted and control samples.	Activities will be primarily supervised; some independence may be needed for the final stages of image processing and analysis, as appropriate to the student's abilities.	None.	N/A	Yes	Yes	Yes	Not currently interested or available for Non-Shapiro research mentoring of medical students	Not currently available to mentor other students	Field AS, Samsonov A, Alexander AL, Mossahebi P, Duncan ID. Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination. J Magn Reson Imaging 2019 May;49(5):1304-1311. doi: 10.1002/jmri.26300. PMID:30302903	Yes	Alexey Samsonov, PhD (Samsonov@wisc.edu)	Quantitative MRI of Myelin: The Confounding Effects of Brain Tissue Iron Deposition: Several quantitative magnetic resonance imaging (MRI) techniques have recently been developed to assess the myelin content of cerebral white matter in vivo. These techniques may provide critically needed imaging biomarkers for studying multiple sclerosis and other diseases of white matter. However, the reliability of these techniques recently came under scrutiny when it was shown that under certain conditions, they may be sensitive to brain tissue iron deposition and thus provide inaccurate measurements. The purpose of this project is to study the effects of brain tissue iron deposition on quantitative magnetization transfer (qMT) imaging, using ex vivo human brain tissue slices that have been experimentally manipulated to alter their iron content. Specifically, formalin-fixed 1-cm brain tissue slices will be divided into left and right halves; one half will be soaked in an iron chelating agent to remove the iron content while the other half will serve as the control. The two halves will remain identical with respect to myelin content. Both halves will then undergo qMT imaging to measure the macromolecular proton fraction (MPF) in several regions known for accumulating iron deposits but also containing myelin, such as the basal nuclei. The MPF is an imaging metric recently promoted as a myelin biomarker, thus it should not significantly differ between iron-extracted and control samples. If it does, we will have shown that MPF is an unreliable myelin biomarker in the presence of tissue iron. ____________________________________________________________________________ Role - The student will first assist a neuropathologist to extract 1-2 whole brains during autopsy, fix them in formalin, slice them appropriately, and prepare control and iron-chelating buffer solutions for soaking the tissue slices before imaging. The student will then assist a MRI physicist in preparing the tissue slices in a suitable container to then perform the qMT imaging. Finally, the student will assist the physicist to process the images, derive region-based measurements of MPF and statistically compare them between iron-extracted and control samples. ; IRB Status - N/A; Skills - None.	Aaron Field, afield@uwhealth.org -- Co-Mentor: Shahriar Salamat	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnueVt__diLvK_YzWLf3Kh_4xnH7UEMXp87rpOKEn-wKhELWLOcPZQWGitsULGJ2-KtY
06/02/2021	lschnapp@medicine.wisc.edu	Lynn	Schnapp	MD	Professor, Chair of Medicine	608	Medicine	Pulmonary and Critical Care Medicine	Cell and Regenerative Biology		Carole Wilson, Visiting Associate Professor	cwilson@medicine.wisc.edu	Medicine	Pulmonary and Critical Care Medicine	Mechanisms in lung injury, inflammation and repair	Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn	1	The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab.	We can tailor the project to the student’s interests and aptitude. The student would work closely with lab personnel.	Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm.	n/a	Yes	Yes	Yes	Shorter term projects, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity, Willing to work with interested students to develop an appropriate research experience	PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	1. Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4. Chest. 1;146(6):1543-53. 2014. PMC4251616 2. Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, Altemeier WA, Matute-Bello G. CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 308(8):L759-65. 2015 3. Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methe BA, Kaminski N, Sandhaus RA, GRADS Alpha-1 Study Group. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc. 12(10):1551-60. 2015. PMC4627425. listed collaborator 4. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 12(10):1561-71 2015. PMID: 26193069. listed collaborator 5. Gharib SA, Malur A, Huizar I, Barna BP, Kavuru MS, Schnapp LM, Thomassen MJ. Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 17(1):93. 2016 Shared senior authorship. 6. Crothers K, Petrache I, Wongtrakool C, Lee PJ, Schnapp LM, Gharib SA. Widespread activation of immunity and pro‐inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange. Physiological Reports. 4(8) pii: e12756. 2016. PMC4848721. Shared senior authorship. 7. Attia EF, Jolley SE, Crothers K, Schnapp LM, Liles WC. Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Elevated in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome. PLoS One. 11(2):e0149687. 2016 Shared senior authorship. 8. Hung CF, Chow YH, Liles WC, Altemeier WA, Schnapp LM. Ablation of Pericyte-like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. Am J Respir Cell Mol Biol. 56(2):160-167 2017. PMC5359647. (Featured in “Red Alerts” highlighted articles) 9. Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA. Lung pericyte-like cells are functional immune sentinel cells. Am J Physiol Lung Cell Mol Physiol. 312(4): L556-L567. 2017. PMC5407093. (Chosen for “APSselect” highlight) 10. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Strange S, for QUANTUM-1 Investigators. Serum proteins associated with emphysema progression in severe alpha-1 antitrypsin deficiency. Chronic Obstr Pulm Dis. 4(3): 204-216. 2017 11. Mohan A, Malur A, McPeek M, Barna BP, Schnapp LM, Thomassen MJ, Gharib SA. Transcriptional Survey of Alveolar Macrophages in a Murine Model of Chronic Granulomatous Inflammation Reveals Common Themes with Human Sarcoidosis. Am J Physiol Lung Cell Mol Physiol. 314(4):L617-L625, 2017. PMC5966779 *Shared senior authorship. 12. Stephenson SE, Wilson CL, Crothers K, Attia EF, Wongtrakool C, Petrache I, Schnapp LM. Impact of HIV Infection on Alpha-1 Antitrypsin in the Lung. Am J Physiol Lung Cell Mol Physiol. 314(4):L583-L592. 2017. PMC5966776 13. Hung CF, Wilson CL, Chow YH, Schnapp LM. Role of integrin alpha8 in murine model of lung fibrosis. PLoS One. 13(5):e0197937. 2018. PMC5973593. 14. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 218(12):1995-2005, 2018. 15. Wilson CL, Stephenson SE, Higuero JP, Feghali-Bostwick C, Hung CF, Schnapp LM Characterization of human PDGFRβ-positive pericytes from IPF and non-IPF lungs. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18. doi: 10.1152/ajplung.00289.2018. PMID:30335500 16. Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group. The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. Am J Med Sci. 2019 May;357(5):405-410. PubMed PMID: 31010467. 17. Hung CF, Wilson CL, Schnapp LM. Pericytes in the Lung. Adv Exp Med Biol. 2019;1122:41-58. PubMed PMID: 30937862. 18. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest 2021. 19. Stephenson SE, Wilson CL, Bond NG, Kaur A, Alvarez X, Midkiff CC, Schnapp LM. Pericytes as novel targets for HIV/SIV infection in the lung. Am J Physiol Lung Cell Mol Physiol 2020; 319: L848-l853. 20. Mohan A, Neequaye N, Malur A, Soliman E, McPeek M, Leffler N, Ogburn D, Tokarz DA, Knudson W, Gharib SA, Schnapp LM, Barna BP, Thomassen MJ. Matrix Metalloproteinase-12 Is Required for Granuloma Progression. Front Immunol 2020; 11: 553949.	Yes	jewerndli@medicine.wisc.edu	Mechanisms in lung injury, inflammation and repair: Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (e.g., Acute Respiratory Distress Syndrome, pneumonia) but progresses to end-stage damage or fibrosis in other circumstances (e.g., emphysema or Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of injury and fibrosis. To complement these studies, we are analyzing bronchoalveolar lavage fluid and peripheral blood from patients with ARDS, HIV and other lung diseases using cutting-edge methodologies such as transcriptomics and proteomics to identify new pathways and molecular targets. https://www.medicine.wisc.edu/people-search/people/staff/7084/Schnapp_Lynn ____________________________________________________________________________ Role - The student would have the opportunity to assist in analyzing data from ongoing experiments with mice. The focus would be on assessing different parameters of lung injury, such as changes in lung permeability and histology, as well as cytokine levels and cellular content and composition in the bronchoalveolar lavage. Other opportunities include working with human and mouse lung cells in culture to examine their responses to inflammatory and profibrotic mediators and how these responses are altered by therapeutics being tested in the lab. ; IRB Status - n/a; Skills - Previous experience in a lab setting is not required – just inquisitiveness and enthusiasm.	Lynn Schnapp, lschnapp@medicine.wisc.edu -- Co-Mentor: Carole Wilson, Visiting Associate Professor cwilson@medicine.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnufQIxCd8I7lckgCRw59ITpuDAvTxYiHkYiFM2f9sdQFd45Hl_aTkksnuUaoeyr8rgg
11/02/2021	kruse@ortho.wisc.edu	Lisa	Kruse	MD	Assistant Professor of Orthopedic Surgery	3.147.490.937	Orthopedics and Rehabilitation	Hand Surgery							Tendon Ruptures and Association with Microvascular disease	Tendon ruptures are a relatively common occurrence. Tendon ruptures have been correlated with statin drug utilization. Atherosclerosis can result in fibrotic changes and potentially weaken tendon over time. This study examined whether tendon ruptures were correlated with hypercholesterolemia/microvascular disease. We are comparing cholesterol levels in patients who underwent surgical management for tendon rupture (distal biceps, distal triceps, quadriceps, achilles, pectoralis, proximal hamstring) and comparing them to matched controls with traumatic finger amputation as well as population norms. Our clinical question is: Is there a correlation between hypercholesterolemia/microvascular disease and tendon rupture in unsheathed tendons?	1	Help with data acquisition (chart review), data analysis, and manuscript preparation		Motivated with some interest in statistics	approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	UW undergraduates interested in research	N/A	No	Katie Schjei Schjei@ortho.wisc.edu research coordinator	Tendon Ruptures and Association with Microvascular disease: Tendon ruptures are a relatively common occurrence. Tendon ruptures have been correlated with statin drug utilization. Atherosclerosis can result in fibrotic changes and potentially weaken tendon over time. This study examined whether tendon ruptures were correlated with hypercholesterolemia/microvascular disease. We are comparing cholesterol levels in patients who underwent surgical management for tendon rupture (distal biceps, distal triceps, quadriceps, achilles, pectoralis, proximal hamstring) and comparing them to matched controls with traumatic finger amputation as well as population norms. Our clinical question is: Is there a correlation between hypercholesterolemia/microvascular disease and tendon rupture in unsheathed tendons? ____________________________________________________________________________ Role - Help with data acquisition (chart review), data analysis, and manuscript preparation ; IRB Status - approved; Skills - Motivated with some interest in statistics	Lisa Kruse, kruse@ortho.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudQj-mjPRGVGRfNdoNQh9A35KZXo9Zd7HQO1Q95xAD04JqCSVqT6ouR2e0z3Hju1l4
17/02/2021	nichol@surgery.wisc.edu	Peter	Nichol	MD/PhD	Associate Professor	6.085.126.357	Surgery	Pediatric Surgery			none				measuring rates of surgical instrument errors in the Operating Room	Surgical instrument errors (Lost, contaminated, and broken instruments) are estimated to result in $11,000,000 in lost capacities (delays) in the operating rooms of University Hospital (UH) and the American Family Children's Hospital (AFCH) annually. These estimates are derived from grounded theory interviews of staff as well as an analysis of patient safety notifications (PSNs) and the cost of an OR minute during prime working hours ($153). These estimates however, were not based on direct measurements and thus are considered "soft" or "imprecise." Lost OR capacity contributes to increased OR costs and stress on the staff often times arising from conflict between staff and surgeons over missing or damaged instruments. We hypothesize that PSNs (our most quantitative measurement tool to date) underestimate instrument error rates by 10- to 20-fold. To test this, we will deploy a team of trained observers in the AFCH operating rooms over a 4 week period to directly measure instrument error rates as well as measure the length of delay resulting from these errors. As UH and AFCH share the same sterile processing facilities and teams for instruments, we will be able to extrapolate an error rate across the two facilities as well as make an accurate assessment of the cost of the cost of these delays. Notably, to our knowledge and based on a recent review of the literature, this will be the first time that a project like has ben undertaken.	0	Study coordinator/leader, data analysis, teaching observers, developing survey tool	high	strong organizational skills	N/A as does not involve human subjects. QI study only	No	Yes	Yes	Shorter term projects, Research Electives for credit	RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	currently none, however, i recently closed my developmental biology lab and have drafted white papers on this very subject for the Hospital	Yes	Dr. Charles Leys	measuring rates of surgical instrument errors in the Operating Room: Surgical instrument errors (Lost, contaminated, and broken instruments) are estimated to result in $11,000,000 in lost capacities (delays) in the operating rooms of University Hospital (UH) and the American Family Children's Hospital (AFCH) annually. These estimates are derived from grounded theory interviews of staff as well as an analysis of patient safety notifications (PSNs) and the cost of an OR minute during prime working hours ($153). These estimates however, were not based on direct measurements and thus are considered "soft" or "imprecise." Lost OR capacity contributes to increased OR costs and stress on the staff often times arising from conflict between staff and surgeons over missing or damaged instruments. We hypothesize that PSNs (our most quantitative measurement tool to date) underestimate instrument error rates by 10- to 20-fold. To test this, we will deploy a team of trained observers in the AFCH operating rooms over a 4 week period to directly measure instrument error rates as well as measure the length of delay resulting from these errors. As UH and AFCH share the same sterile processing facilities and teams for instruments, we will be able to extrapolate an error rate across the two facilities as well as make an accurate assessment of the cost of the cost of these delays. Notably, to our knowledge and based on a recent review of the literature, this will be the first time that a project like has ben undertaken. ____________________________________________________________________________ Role - Study coordinator/leader, data analysis, teaching observers, developing survey tool; IRB Status - N/A as does not involve human subjects. QI study only; Skills - strong organizational skills	Peter Nichol, nichol@surgery.wisc.edu -- Co-Mentor: none	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudizaz7PPq0qQ_FNFVkqh7kIbHt9UuXznS6WOWkepUjv95kYcljaUDjZJIvq7sCeSc
01/03/2021	RJMATTISON@MEDICINE.WISC.EDU	Ryan	Mattison	MD	Associate Professor		Medicine	Hematology/Oncology			Lauren Banaszak	lbanaszak@uwhealth.org	Medicine	Medicine	Influence of somatic mutations on outcomes in AML and MDS	We have a database of 470 patients presenting to UWHealth from 2010-2019 with a new diagnosis of AML or MDS. We have data on co-morbidities at diagnosis, cytogenetics, molecular data, treatment, complications, and mortality data.	1	The student would have the opportunity to assist with data collection to update the database to include patients diagnosed through 2020. The student would work closely with current Chief Resident/soon-to-be Hematology/Oncology fellow to perform data collection and would receive extensive training. The student could then use the dataset to develop his or her own clinical question, perform data analysis (with the help of a biostatistician), and draft an abstract for presentation or even publication.	The student would receive extensive training on data collection but then would be able to perform data collection independently. The student would have the opportunity to develop a clinical question, design a study, and draft an abstract/manuscript with the assistance of the mentors if desired.	Familiarity with UW Health Link is desired but not required	Approved	No	No (plan to use Dean's Office Funds)	Yes	Shorter term projects	Not currently available to mentor other students	"Clinical utility and real-world application of molecular genetic sequencing in the management of patients with AML and MDS." Abstract presented at ASH 2019, manuscript in preparation.	No	N/A	Influence of somatic mutations on outcomes in AML and MDS: We have a database of 470 patients presenting to UWHealth from 2010-2019 with a new diagnosis of AML or MDS. We have data on co-morbidities at diagnosis, cytogenetics, molecular data, treatment, complications, and mortality data. ____________________________________________________________________________ Role - The student would have the opportunity to assist with data collection to update the database to include patients diagnosed through 2020. The student would work closely with current Chief Resident/soon-to-be Hematology/Oncology fellow to perform data collection and would receive extensive training. The student could then use the dataset to develop his or her own clinical question, perform data analysis (with the help of a biostatistician), and draft an abstract for presentation or even publication. ; IRB Status - Approved; Skills - Familiarity with UW Health Link is desired but not required	Ryan Mattison, RJMATTISON@MEDICINE.WISC.EDU -- Co-Mentor: Lauren Banaszak lbanaszak@uwhealth.org	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuePuvFh25G3-D13DMsqB-ZyCJDD231GEpCIT15RPsH75oJHgORhslMcH0usPPv4z04
03/03/2021	fcaldera@medicine.wisc.edu	Freddy	Caldera	DO	Associate Professor	6.086.288.201	Medicine		Other		Mary Hayney	Mary.hayney@wisc.edu	Other	School of Pharmacy	Evaluating COVID-19 vaccine uptake among patients with gastrointestinal conditions	The project will evaluate the uptake of COVID-19 vaccine uptake among patients with gastrointestinal conditions	1	Data collection	will do data collection on their own.	data entry, and excel management.	Pending.	No	No (plan to use Dean's Office Funds)	Yes	Research Electives for credit	MPH students	Disparities in influenza vaccine uptake among patients with IBD	Yes	n/a	Evaluating COVID-19 vaccine uptake among patients with gastrointestinal conditions: The project will evaluate the uptake of COVID-19 vaccine uptake among patients with gastrointestinal conditions ____________________________________________________________________________ Role - Data collection ; IRB Status - Pending.; Skills - data entry, and excel management.	Freddy Caldera, fcaldera@medicine.wisc.edu -- Co-Mentor: Mary Hayney Mary.hayney@wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnudYsJ77_N5REHSlz-fUElWneA3mVKoPmOKndHVBglqWo2nPOA4yz8hn5kn-RfBfD3g
04/12/2020	McGuine@ortho.wisc.edu	Tim	McGuine	PhD	Distinguished Scientist	608	Orthopedics and Rehabilitation	Sports Medicine			Pamela Lang MD	PLang@ortho.wisc.edu	Orthopedics and Rehabilitation		UW Orthopedics Youth Knee Injury Registry	The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes.	0	1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production	Moderate	Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents	HS-IRB 2019-0028 - Approved	No	Yes	Yes	Shorter term projects, Research Electives for credit	DPT students, MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	McGuine TA, Pfaller A, Kliethermes S, Schwarz A, Hetzel S, Hammer E, Broglio S. The effect of sport-related concussion injuries on concussion symptoms and health-related quality of life in male and female adolescent athletes: a prospective study. Am J Sports Med. 2019;47(14):3514–3520 DOI: 10.1177/0363546519880175 Kijowski R, Thurlow P, Blankenbaker D, Liu F, McGuine TA, Li G, Tuite M. Preoperative MRI Shoulder Findings Associated with Clinical Outcome 1 Year after Rotator Cuff Repair. Radiology. 2019 Apr 23;291(3):722-9. McGuine TA, Post EG, Hetzel, S, Pfallar A, Brooks MA, Bell D. A Prospective Study on the Impact of Sport Specialization on Lower Extremity Injury Rates in High School Athletes. American Journal of Sports Medicine. doi.org/10.1177/0363546517710213 McGuine TA, Hetzel S, Carr K, Winterstein A. Changes in Health-Related Quality of Life and Knee Function After Knee Injury in Young Female Athletes." Orthopedic Journal of Sports Medicine. 2.4 2014: DOI: 2325967114530988. Winterstein A, McGuine TA, Hetzel S, Carr K. Changes in Self-reported Physical Activity Following Knee Injury in Active Females. Athletic Training and Sports Health Care. 2013 5(3):106-114. McGuine TA, Hetzel S, Pennuto T, Brooks MA. Basketball Coaches' Utilization of Ankle Injury Prevention Strategies Sports Health: A Multidisciplinary Approach 2013;5(5):410-416. McGuine TA, Winterstein A, Carr K, Hetzel S, Scott J. Changes in Self-Reported Knee Function and Health-Related Quality of Life After Knee Injury in Female Athletes. Clinical Journal of Sports Medicine 2012; 22(4):334-340. Kijowski R, Sanago M, Lee K, Munoz del Rio A, McGuine TA, Baer G, Graf BK, De Smet AA. Short-term Clinical Importance of Osseous Injuries Diagnosed at MR Imaging in Patients with Anterior Cruciate Ligament Tear. Radiology. 2012; 264 (2): 531-541. Kijowski R, Woods MA, McGuine TA, Wilson JJ, Graf BK, De Smet AA. Arthroscopic partial meniscectomy: MR imaging for prediction of outcome in middle-aged and elderly patients. Radiology. 2011: 259(1);203-212.	Yes	Heidi Ableidinger (Ableidinger@ortho.wisc.edu); Emily Kay Koresh (ekoresh@wisc.edu); Liana Nash (Nash@ortho.wisc.edu)	UW Orthopedics Youth Knee Injury Registry: The purpose of this study is to collect youth patient outcome data to conduct ongoing descriptive or comparative analysis of outcomes for youth patients who are treated for orthopedic knee conditions and injuries and at UWHC Clinics, and to identify the risk factors associated with various outcomes. This study will consent and enroll subjects from youth patient populations seeking treatment for various orthopedic knee pathologies and conditions at UW Health facilities. Subjects will be asked to complete a series of self-report questionnaires prior to surgery/treatment and at regular intervals post-surgery/treatment. Additional data (level of youth sport participation, other subject characteristics, surgical procedures, treatment dates) will be obtained by the study team by querying the EMR of consented subjects. The study team will query the data as needed to answer specific research questions and plan future research studies conducted at UW Madison. The initial queries planned for 2020 include determining the level of youth sports participation that is associated with various knee pathologies and long term health outcomes. ____________________________________________________________________________ Role - 1) Assisting with subject recruitment and enrollment, 2) Querying the database, 3) Accessing individual subject's EMR to collect surgical and treatment data, 4) Summarizing and producing data reports, 5) Assisting with abstract and manuscript production; IRB Status - HS-IRB 2019-0028 - Approved; Skills - Entering and editing data, running data queries on MS Excel and or REDCap, Interpersonal skills that highlight the ability to interact with potential subjects and their parents	Tim McGuine, McGuine@ortho.wisc.edu -- Co-Mentor: Pamela Lang MD PLang@ortho.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnud-cQdhJmHlXEWPs6dqS2CGvUUuPkizNN5OAeayRuRvS6ZL-GrLr4suSjSAyUXwyy0
15/12/2019	dlamming@medicine.wisc.edu	Dudley	Lamming	Ph.D.	Assistant Professor	608	Medicine	Endocrinology, Diabetes and Metabolism			Associate Professor Dawn Davis, MD, PhD	dbd@medicine.wisc.edu	Medicine	Endocrinology, Diabetes and Metabolism	Improving metabolic health through reduced consumption of specific dietary amino acids	Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/	0	The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation.	Medium - students will be co-mentored by Dr. Davis and will be supervised in the clinic by Dr. Rowan Karaman, a VA Advanced Fellow and UW Instructor, but will also work independently. Similarly, students will be trained in any mouse or cell culture work but will be expected to complete experiments independently. Students will analyze data and prepare presentations.	None	Approved	Yes	The Department of Medicine routinely provides this funding for Shapiro students.	Yes	Shorter term projects, Research Electives for credit, Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship), Interested and funded to provide another yearlong mentoring opportunity	MPH students, PhD students, RUSCH pre-med students (https://www.med.wisc.edu/education/rusch/), UW undergraduates interested in research	Fontana et al, 2016, Cell Reports, PMID: 27346343; Cummings et al, 2018, J Physiology, PMID: 29266268; additional manuscripts under review	Yes	N/A	Improving metabolic health through reduced consumption of specific dietary amino acids: Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are notoriously difficult to sustain. Branched-chain amino acids (BCAAs; leucine, isoleucine and valine), which are important components of dietary protein, are elevated in the blood of obese, insulin-resistant humans and rodents. We recently demonstrated that specifically reducing dietary levels of the BCAAs rapidly reduces fat mass in diet-induced obese mice, restoring normal weight and blood sugar control even as mice continue to eat large quantities of a high-fat, high-sugar Western diet. We have initiated a human clinical trial to test the feasibility and metabolic benefits of reducing dietary BCAAs consumed by overweight, pre-diabetic subjects. Our lab website is: http://www.lamminglab.org/ ____________________________________________________________________________ Role - The exact role of the student will depend on our success at recruiting and retaining subjects during the course of the approximately 2 month clinical study. We envision the student will engage in contact with our last few patients, maintaining contact on a weekly basis, scheduling and accompanying patients; and also assisting in analyzing data and blood samples obtaining from the patients before, during and after the trial. We are also launching a second followup clinical trial. Cell or animal work will also be performed to examine the consequences of changes in the blood of our human subjects, and to examine the effects of other dietary amino acids in either mice or humans. Please contact Dr. Lamming for a more detailed explanation.; IRB Status - Approved; Skills - None	Dudley Lamming, dlamming@medicine.wisc.edu -- Co-Mentor: Associate Professor Dawn Davis, MD, PhD dbd@medicine.wisc.edu	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnuc3LysPzBsijg_sPEzKe6uw7sYL-fzHAHXHRXTgYS1Mxl_IRQo-RQocjrb9085fWOE
21/11/2019	gibson@surgery.wisc.edu	Angela	Gibson	MD, PhD	Assistant Professor	6.082.659.574	Surgery	Acute Care and Regional General Surgery							Use of human skin to model burn injury and complex wound healing	There are various projects in different stages of maturity in the Gibson lab that would be suitable for a medical student to contribute to over the summer, depending on their interests, including the following two projects with direct clinical applicability. One project involves a feasibility study of ICG fluorescence as a biomarker for necrosis in human burn wounds - this is a translational project on burn patients as well as developing assays in the lab to evaluate the mechanism. Another project involves the evaluation of the cytotoxicity and efficacy of antiseptics in infected human skin wounds. For more information on the Gibson lab please visit: https://www.surgery.wisc.edu/research/researchers-labs/dr-gibsons-lab/	0	Taking the lead on a part of the project with direct oversight from scientist in lab	independent after training on techniques	prior research experience with tissue culture and molecular biology preferred but not necessary	approved	Yes	No (plan to use Dean's Office Funds)	Yes	Interested in serving as a mentor for a yearlong fellowship (e.g., ICTR Shapiro fellowship)	PhD students	Karim, A., Shaum, K., Gibson, A. “Indeterminate depth burn injury - Exploring the uncertainty.” Journal of Surgical Research. 2020 Jan;245:183-917. Published online August 14 2019. Karim, A., Yan, A., Ocotl, E., Bennett, D., Wang, Z., Kendiorski, C., Gibson, A. “Discordance between histologic and visual assessment of tissue viability in excised burn wound tissue”. Wound Repair and Regeneration. 2019 Mar;27(2):150-161. Epub 2018 Dec 26. Gibson, A., Bennett, D., Taylor, L. “Improving the histologic characterization of burn depth.” Journal of Cutaneous Pathology. 2017 Dec;44(12):998-1004. Gibson, A., Shatadal, S. “A simplified and improved method to determine cell viability in burn-injured tissue.” Journal of Surgical Research.2017 Jul;215:83-87. Israel, J., Greenhalgh, D., Gibson, A. “Variations in burn excision and grafting: A survey of the American Burn Association.” Journal of Burn Care and Research. 2017 Jan/Feb;38(1):e125-e132. Schroeder, A.; Karim, A., Ocotl, E., Dones, J., Chacko, J., Liu, A., Raines, R., Gibson, A., Eliceiri, K., Optical imaging of collagen fiber damage to assess thermally injured human skin. In preparation with revisions to Wound Repair and Regeneration.	No	Dr. Aiping Liu	Use of human skin to model burn injury and complex wound healing: There are various projects in different stages of maturity in the Gibson lab that would be suitable for a medical student to contribute to over the summer, depending on their interests, including the following two projects with direct clinical applicability. One project involves a feasibility study of ICG fluorescence as a biomarker for necrosis in human burn wounds - this is a translational project on burn patients as well as developing assays in the lab to evaluate the mechanism. Another project involves the evaluation of the cytotoxicity and efficacy of antiseptics in infected human skin wounds. For more information on the Gibson lab please visit: https://www.surgery.wisc.edu/research/researchers-labs/dr-gibsons-lab/ ____________________________________________________________________________ Role - Taking the lead on a part of the project with direct oversight from scientist in lab; IRB Status - approved; Skills - prior research experience with tissue culture and molecular biology preferred but not necessary	Angela Gibson, gibson@surgery.wisc.edu -- Co-Mentor:	https://docs.google.com/forms/d/e/1FAIpQLSdy53oqyX4I3HLu9goTklTF-CIspXdZ6riVHKWJcjLhptfG-Q/viewform?edit2=2_ABaOnucoe5Qj0mNjBhhfXnvDRfPQd1e3H6k_mkesFgJhgCWphi7ze2-H00Zqye43oIB3SYA
Timestamp	Email Address	Mentor First Name	Mentor Last Name	Degree	Title	Phone Number	Dept.	Primary Department Division	Secondary Department	Secondary Department Division	Co-Mentor Name	Co-Mentor Email	Co-Mentor's Primary Department	Co-Mentor's Primary Department's Division	Project Title	Project Description	Open Slots	Student's Role	Degree of Independence Required	Skills Required	IRB Status of Project	Do you have current NIH or other external funding?	Do you have funding to cover 50% of the Shapiro summer student's stipend?	Do you have resources to provide all needed supplies to support the student research experience?	Non-Shapiro Opportunities	Are you interested in mentoring non-medical students?	Please list all relevant manuscripts (published or in preparation) in the last 5 years that are directly relevant to the project you proposed.	Have you completed any mentoring training?	Please include names and contact information of key staff in your department or lab who will need to be informed of your incoming Shapiro students	Project Information	Mentor Information	Response URL	Test Email Address